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Recover from Trauma with Large Doses of Rejuvenate!™

Fred Liers PhDNearly two years ago, I was involved in a high-speed automobile accident. I was driving with my family on a major road when suddenly we were struck head on by a Jeep Cherokee SUV whose driver failed to yield on a green light, and fatefully crossed our path while making a left turn.

I escaped with minor injuries, except for a torn anterior cruciate ligament (ACL) in my right knee. Technically, the diagnosis was a torn ligament with deep bone bruising, a fractured tibia, and a torn meniscus. The doctor recommended surgery to “reconstruct” my ACL using one of my own hamstring ligaments.

As it turned out, one of the first health professionals to look at my knee (after the ER doctor) was a bodyworker friend. He worked on me for several hours. At some point, he re-aligned the chondials in my knee. Before that I could not walk. So, I was quite fortunate since I could now at least get around, first with crutches, and then without them.

Surgery would be postponed for six months partly because I could not afford down time away from teaching my university classes until the semester was complete. Also, my knee bruising was so deep that the swelling would take months to disappear completely (a condition for surgery).

I seriously considered avoiding surgery. I hoped to heal my knee using nutrition and rehabilitation alone. Yet, I found myself unstable and prone to falls in particular. Falls were often accompanied by great pain, bruising, swelling, and at least three days recovery time for pain to dissipate.

Also, my knee joint was wobbly, and it would go out of alignment and even just give way (usually causing a fall). Sometimes, it would just pop out of place while walking or standing. This necessitated adjustments to get it back “in place.”

Staircases were a particular challenge since I never knew when the knee would give way. Handrails narrowly saved me from falling several times. I was especially grateful for handicapped ramps, which I used to avoid stairs whenever possible. (I also thank the DMV for a six-month temporary handicapped placard.)

I had never experienced major injuries as an adult. I was a successful distance runner in high school, as well as a collegiate race walker. I participated actively in martial arts followed by more than a decade of yoga. Now I could barely walk. It was unfathomable and strange. I felt for all individuals who couldn’t walk, the disabled, and for all incapacitated persons. There’s nothing like direct experience. My perspective on many things is changed forever. For the better, of course.

I ultimately decided in favor of surgery, as my doctor recommended.

MY PLAN OF ACTION

For several days, while recovering from a bruising fall (due to my knee giving way), I finally took time to seriously consider my best options for a fast recovery after surgery. I listed all the things (supplements, practices, techniques) I would do to create the most rapid return to normal function, walking, and ultimately running.

For example, I would have acupuncture immediately after surgery. I would ask for the minimum anaesthetic possible and I would avoid painkillers. I would continue my nutritional supplement regimen (see below), but add extra supplements for joint health, more antioxidants, and anti-inflammatory nutrients. I would be diligent about doing my physical therapy. As always, I would continue to meditate daily, but I would add guided visualizations for healing the knee. I would eat an extremely pure diet with a focus on organic vegetables and raw foods, as well as high-quality proteins.

Most of all, I would take large doses of REJUVENATE!™. I remembered back to the intense period in 2005–2006 when we (at HPDI) first taste-tested various versions of original Rejuvenate!™ superfood. I always volunteered (and still volunteer) as the #1 “guinea pig” during product development. I started slowly, but eventually took 10, 15, and even 20 scoops daily! One scoop is about 12 grams (or two tablespoons). I basically swilled this stuff all day. I ate, drank, breathed, and dreamed Rejuvenate!™ for months. I loved it!

I recalled how dramatically my energy levels increased when I took large doses (at least 8–10 scoops or more) of REJUVENATE!™. In addition, I had healed faster, gained greater muscle mass and functional strength, and had noticeably better lung capacity. I also lost some weight. Most intriguingly, I actually grew a little bit (in my early 40s no less!). It was a time of great discovery, intellectual ferment, as well as dark green Rejuvenate!™ lips and “mustaches” (“Got Greens?” we joked). Since then, I always take at least one or two scoops daily.

After the initial testing period for original Rejuvenate!™, I eventually stopped extremely large doses of it. This was partly because I discovered I gained most of the benefits at smaller doses. In fact, I benefit even from one or two scoops daily. Besides, I had started taking a few scoops daily of our newer Rejuvenate!™ formulas (i.e,. Rejuvenate!™ PRO, Rejuvenate!™ PLUS, Rejuvenate!™ Berries & Herbs, or  Rejuvenate!™ Strawberry-Peach Protein Plus), so I felt I was getting more than enough RNA from the combination of superfoods.

But now, everything had changed. Surgery would tax my body unlike anything else in my experience. I was already feeling quite taxed because my knee pain was virtually constant due to weekly falls. Even the original swelling from the accident had yet to resolve.

As I lay there in pain, reflecting upon my early experiences with large doses of original Rejuvenate!™, I realized I needed large doses of RNA for healing, both now and after surgery. It became clear to me that Rejuvenate!™ original would be the best single formula that could ensure a speedy recovery. I would take large doses of it.

I had good reasons for my decision to take large doses. First, original Rejuvenate!™ provides as much therapeutic dietary RNA as any other Rejuvenate!™ superfood. Dietary RNA (or nucleic acids) are the “secret” behind the healing power of the Rejuvenate!™ line, and indeed they remain the first and only dedicated high-RNA superfoods to this day.

Dietary RNA speeds (some say quadruples) healing time, increases cellular energy (as ATP) needed to improve cell functioning and optimize metabolic processes, boosts oxygenation, increases strength and endurance, and much more (see benefits list for RNA for Rejuvenate!™).

Rejuvenate!™ original provides about 340 mg of RNA (dietary nucleic acids) per serving. This is approximately the same amount of RNA per serving as all Rejuvenate!™ formulas provide (see Rejuvenate!™ comparison table).

Secondly, original Rejuvenate!™ remains our “greenest” superfood formula—providing the most chlorella, spirulina, and chlorophyll—in the Rejuvenate!™ line. The presence of these greens make it the most effective “healer” (gram for gram), at least for major trauma. Unlike some other Rejuvenate formulas (i.e., the PLUS and Berries & Herbs formulas), the original does not provide multivitamins, or even B vitamins (as Rejuvenate!™ PRO does).

EFFECTIVENESS AND COST EFFECTIVENESS

Another major advantage is cost. Rejuvenate!™ original is the most highly concentrated source of RNA and other nutrients (e.g., chlorella and chlorophyll) in the Rejuvenate!™ line. Therefore, serving sizes are smaller (12 grams) and there are more servings per container. In fact, there are 42 servings (i.e., scoops) per container, which gives it the lowest cost per serving among all Rejuvenate!™ formulas.

My primary concern was never cost, of course, but effectiveness. Turns out the same concentration of nucleic acids (i.e., RNA density) that makes Rejuvenate!™ economically viable also allows it to provide the most healing RNA per gram.

Thus, given that the cost of original Rejuvenate!™ compares favorably to other Rejuvenate!™ formulas (some of which provide 16 servings per container), it is clear from a cost-benefit basis that original Rejuvenate!™ provides the greatest “bang-for-the-buck”and the biggest “bang-per-gram,” at least in terms of dosages of RNA and other dietary nucleic acids.

A healthy person (i.e., someone not experiencing trauma) can take a maintenance dose of one scoop daily for six weeks from a single container of Rejuvenate!™. When taking two scoops daily, a container lasts three weeks. Either way, this person would obtain therapeutic levels of RNA, despite relatively “small” servings of Rejuvenate!™.

For someone experiencing trauma or needing to heal, a relatively “large” dose of five scoops daily could still be provided by one container for more than eight days! (Compared to the cost of pharmaceuticals that do little or nothing to heal someone, the cost of Rejuvenate!™ starts to look like a real bargain.)

To be fair, the newer Rejuvenates offer significant additional features (e.g., built-in multivitamins, minerals, healing herbs) providing major benefits (especially when combined with RNA) that go well beyond the scope of original Rejuvenate!™. Yet, if you already take multivitamins and other supplements separately (as I usually do), and your primary interest lies in maximizing RNA intake, then original Rejuvenate!™ is by far the best choice.

In sum, original Rejuvenate!™ is especially appropriate when large amounts of RNA are required for healing, i.e., during times of injury, accidents, surgery and other medical interventions, trauma or critical conditions, and even for detoxification (heavy metals or chemical toxins).

TAKING LARGE DOSES OF REJUVENATE!™

I did not feel hungry for months following the accident. My lack of appetite extended for at least six months after the accident and then continued after the surgery. I suppose the trauma from the accident took away all desire to eat. Yet, I needed calories. I rapidly lost ten pounds shortly after the accident. Rejuvenate!™ original was tasty, easy-to-consume, and provided nutrients. It would make all the difference in my recovery.

For practical purposes, I already was living on Rejuvenate!™ superfoods months before surgery. It started long before I decided to take large doses of original Rejuvenate!™. While I forced myself to have a solid breakfast, most of the day I lived on Rejuvenate!™ original, and to a lesser extent Rejuvenate!™ PRO, and PLUS. I would mix them into smoothies, or shake them into rice milk or filtered water.

Prior to my decision to take large doses of Rejuvenate!™ original, I probably took a total of five scoops daily of various Rejuvenates combined. This was a good baseline. It provided reasonably large amounts of RNA and helped me to heal faster than I would otherwise. It also “preloaded” my body with RNA, so it was no shock to my body when I started taking large doses of Rejuvenate!™ original.

Then about six weeks before surgery, I ramped it up. I began taking 8–10 scoops of REJUVENATE!™ superfood (original greens) daily. I typically would take 2–3 scoops per dose, so I consumed three or four doses per day.

One of my favorite drinks was a Rejuvenate!™ “lemonade” made with freshly squeezed lemon or lime juice. I would add two scoops of Rejuvenate!™ to a mason jar, add pure water, the juice of one or two lemons, and possibly a dash of grade-B organic maple syrup. (If no fresh lemons or limes were available, I would often use a splash of Santa Cruz brand organic 100% lemon or lime juice.)

As mentioned, I would often also take up to four scoops per day of REJUVENATE!™ PRO or a few scoops of REJUVENATE!™ PLUS or REJUVENATE!™  Berries & Herbs. But mostly I focused on taking Rejuvenate!™ original.

I also continued my routine of taking a high-potency multivitamin, Vitamin C, essential fats, and a wide variety of antioxidants. Other supplements in my routine included a B-Complex, vitamin E, vitamin A, CLA, astaxanthin, magnesium, MSM, and a joint health formula.

I was also fortunate (and grateful) to receive regular acupuncture treatments from my wife, Stefanie, who is a professional acupuncturist with a master’s degree in oriental medicine. She treated me after the accident and immediately after surgery. Her treatments made a tremendous difference in reducing pain and swelling, and ultimately contributed greatly to my healing.

RAPID RECOVERY AND SUCCESSFUL REHABILITATION

The day for surgery finally arrived. I decided to meditate as the anesthetic overcame me. I probably meditated throughout surgery. The first words I heard as I began to awaken were, “Are you meditating?” Still semi-conscious, I nodded to the nurse, who was pleased to get a rapid response. I left the surgery center that afternoon.

Recovery went smoothly and rapidly. First, the pain of surgery subsided quickly. Then, within the first week, I started walking again with the aid of crutches. In less than ten days, I walked without crutches.

My physical therapist was surprised to see that within two weeks I could extend out my leg while in a seated position almost to zero degrees. He said he almost never saw individuals with ACL injuries who extend so far in such a short period of time. In some cases, it takes months, he said.

In addition, I could now bend my knee nearly at 90 degrees. This meant the swelling from surgery was decreasing far more quickly than commonly occurs. In fact, I could feel and see the swelling decrease daily. I was healing many times faster than I would have otherwise. I attribute this to my action plan, including superior nutrition, and especially to Rejuvenate!™.

Another benefit I’ve always gained from Rejuvenate!™ is increased flexibility in the joints. However, I gain the most benefit at higher dosages, and this increased flexibility was evident during my post-surgical recovery.

Thus, higher doses of Rejuvenate!™ before (and after) my surgery 1) speeded healing, 2) increased strength, 3) improved joint flexibility, and 4) improved cellular oxygenation. These are the precise benefits that explain my ability to bend, lift, exhibit remarkable endurance, and heal rapidly during physical therapy.

Perhaps most surprising to my physical therapist was that I could raise my leg without any “extensor lag” (i.e., delay) on the very first day of physical therapy (i.e., one week after surgery). That is, I could easily lift my leg into the air from a seated (or lying down) position. According to the ACL graft instructions from my surgeon, this would normally be possible only three to four weeks AFTER surgery. My physical therapist recommended an accelerated rehabilitation program. I agreed enthusiastically.

My knee and leg felt stronger each passing day. I removed my brace for extended periods starting the third week after surgery. Before the end of the third week, I could extend my leg out fully to zero degrees. As the week flew by, I began sharing my action plan with my physical therapist. I told him about Rejuvenate!™, my supplement regimen, and benefits of acupuncture. He listened avidly.

During the third week after surgery, I could almost walk with a normal gait. I could also do full rotations on a stationary bike. Within the next few weeks, I could bike for many minutes and go for increasingly longer periods on stairstep-type machine. Thereafter, I began to return to normal activities, including walking greater distances and hiking. I would not attempt to run for a while. But sometime in the third month after surgery I recall my first running steps. It was thrilling to run.

I suppose I should be more amazed by the fact I healed so quickly and gained strength so fast. What surprised me was that I gained functional strength BEFORE surgery. That is, I noticed it was easier lifting objects and my grip strength was stronger within just days of increasing intake of Rejuvenate!™ to 10 scoops per day. That meant improvements in functional strength were due simply to increased dosages. Indeed, to me these improvements were solid indicators that additional energy would be available for accelerated healing and recovery, which was exactly what happened.

Thus, my “surprise” at the benefits of Rejuvenate!™ came before surgery. My enhanced experience with physical therapy was of course very welcome, but less surprising. By then, I just wanted to heal rapidly, then get back to normal life. Rejuvenate!™ helped make it happen!

In sum, the benefits I gained from Rejuvenate!™ included faster healing and recovery, increased strength, greater flexibility, improved oxygenation (i.e., better breathing) for greater endurance and less exertion, less pain (due to faster healing), and maintenance (i.e., less wasting-away) of muscle mass during recovery.

Another major benefit was higher caloric intake due to the ease of consuming Rejuvenate!™. This was especially important because I was hardly hungry for weeks after surgery with little desire to eat anything. Yet, I found it easy to make and take Rejuvenate!™ drinks. They are always tasty and go down easily.

AFTERMATH: POST-RECOVERY HIGH-DOSE REJUVENATE!™

I am happy to be healed! I have much gratitude for the ability to walk, and just to be alive. I’ve learned many things on the path to recovery. I would never wish to have an ACL tear (or any injury for that matter!) again. But I’ve gained perspective. I think in radically different ways since the accident. For example, I don’t take small things (or even big things like walking) for granted.

I still take 8–10 scoops of Rejuvenate!™ on most days. I was so greatly impressed with the extra benefits gained at a higher dosage of Rejuvenate!™ (original) that I continued high-dose intake after my recover. As a result, I continue benefiting from long-term improvements in functional strength, maintenance of high levels of lean muscle mass, greater endurance, easier breathing (via increased tissue oxygenation), high flexibility, tolerance of temperature extremes (heat and cold), as well as better athletic performance in all respects. Other benefits include smoother skin and a younger looking appearance (i.e., well known, proven results of increased intake of dietary nucleic acids (RNA, DNA) that are always welcome).

I highly recommend high dose Rejuvenate!™ to anyone suffering from major injury, chronic illness, or an intractable health problem. I also recommend it to anyone who is serious about detoxification (e.g., of heavy metals or toxic chemicals) or preventing toxicity, and to individuals desiring to improve athletic performance significantly. This latter group includes people who work physically for a living, and who can benefit from greater functional strength and endurance. I have seen many laborers who benefit from taking just one or two scoops a day. Benefits include less hunger, ability to work for efficiently and for longer periods of time.

I also recommend Rejuvenate!™ to those who must look good for a living. This group includes actors, models, public figures, health professionals, and almost anyone who would benefit from appearing younger and in radiant good health. (And who wouldn’t benefit from that?) The deeper truth here is that you will feel as good as you look because the health Rejuvenate!™ helps generate is not just “skin deep.” Instead, it is a reflection of actual good health from the inside out!

In conclusion, taking what I maybe used to think of as “large” doses Rejuvenate!™ is not just for special occasions. I think it can actually be for everyone, or at least most people. As life gets busier, as we get older, and as our environment becomes increasingly toxic (even as our personal environments and diets become less toxic, hopefully), it is clear that we not only need higher density nutrition, but also superfoods that can provide a wide range of benefits (e.g., detoxification, anti-aging effects, antioxidant capabilities).

The Rejuvenate!™ line of superfoods offers just these kinds of advantages. In particular, Rejuvenate!™ (original) offers unique benefits within the Rejuvenate!™ line that can benefit everyone from children to grandparents, athletes to recovery-room patients, and even pets.

There is every reason to believe that superfoods like Rejuvenate!™ are the foods of the future. They are available now, however. There is no reason to wait until an accident, an injury, or a decline in health generates a special need for super nutrition. You (and yours) can benefit starting now.

A superfood I already took at reasonable levels has become, by taking more of it, a superfood giving me optimal health every day. I maximize its effects. I gain all the benefits of peak levels of dietary nucleic acids, which are truly miracle nutrients.

I had never considered the long-term benefits of a dose increase. Now, I will never wonder what benefits I might lose since high-dose Rejuvenate!™ has become an integral part of my life.

The most important thing is you can benefit from Rejuvenate!™ high-RNA superfoods whether or not you take high dosages. However, it is also true that the nutritional power of Rejuvenate!™ is so great you can depend on “dose-dependent” benefits. That is, everyone benefits from even surprisingly small doses. Yet, if certain situations, conditions, or special needs exist, then they will respond positively to high dosages in ways that surpass normal dosage levels. This is the “next level” in terms of benefits and it represents optimal dosing for health.

 

Suggested Reading

Frank, Benjamin S., MD. Nucleic Acid Nutrition and Therapy. New York: Rainstone Publlishing, 1977.

Frank, Benjamin S., MD. Dr. Frank’s No-Aging Diet. New York: Dial Press, 1977.

Health Products Distributors, Inc. (HPDI). “The Master Rejuvenation Program. (http://www.integratedhealth.com/rejuvenation/index.html). c. 2010.

Health Products Distributors, Inc. (HPDI). “Rejuvenate Side-by-Side Comparison.” (http://www.integratedhealth.com/rejuvenate-comparison.html). c. 2010.

Jensen, Bernard. Chlorella: Jewel of the Far East. Escondido, California: Bernard Jensen International, 1992.

Liers, Henry, PhD, and Fred Liers, PhD. The Need for Foundational Supplements (http://www.integratedhealth.com/downloads/foundational-supplements.pdf). Tucson, Arizona: Health Products Distributors, Inc., 2010.

Pauling, Linus. How to Live Longer and Feel Better. Corvallis, Oregon: Oregon State University Press, 2006.

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More Good News about Olive Oil

I love good olive oil! My recent studies into polyphenols and Nrf2 activators have made me more aware than ever of the importance of eating foods that retain the goodness that nature has packaged into foods. So more than ever I search for olive oils that are truly natural.

Recently, I learned that my friend Raymond has produced for him an olive oil that bypasses nutritionally all other olive oils of which I am aware. Raymond has sought out small family-owned farms in California, where the oil is literally produced in ways similar to methods used in ancient Greece and Rome.

Beyond Health Olive Oil

One of the best olive oils I’ve ever found

On these farms, olives are grown without pesticides and picked by hand so as to not damage the skin or pulp. They are transported in well-aerated containers and milled

within 48 hours of harvesting. Before milling, leaves and twigs are removed; the olives are washed, dried, and then crushed. The oil is separated from the olive paste without the use of heat, hot water, or solvents, and it is left unfiltered, as filtering also removes many nutrients.

The first pressing produces the best extra virgin oil. Producing olive oil the old way is more time consuming and costly. The costs of harvesting by hand, to protect the fruit from damage, are high, but necessary to making good oil.

We will soon sell this extra virgin olive oil on the Health Products Distributors, Inc. website. This makes me happy! I always want to make the most health giving foods and nutrients available to our customers.

Interesting, today there was an article on the benefits of olive oil posted on the Natural News website that talks about a recent study published in the American Journal of Clinical Nutrition. The conclusions reached after studying 40,622 participants in a 13.4 year study is that olive oil consumption lowers mortality by a quarter and heart disease by nearly one-half!! Incredible!!!

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Natural Phytochemical Nrf2 Activators for Chemoprevention

Dr. Hank Liers here considers mechanisms involved in the activation of transcription factor Nrf2. Nrf2 is encoded by the NFE2L2 gene. Nrf2 can induce expression of genes encoding for antioxidant enzymes. Thus, it contributes to regulation of oxidative stress. Dr. Liers’ interest regards use of natural phytochemical Nrf2 activators for improving health. Also, see his previous post, “New Directions for Preventing Free-Radical Damage” (06.07.12).

INTRODUCTION
Nrf2 SIGNALING, FOODS, AND HEALTH

Dr. Hank Liers, PhD nrf2 activatorsDespite progress in the early detection and treatment of cancer, overall mortality rates for most cancers of epithelial origin have not declined during the past three decades. Consequently, in recent years attention has been directed to cancer prevention.

Carcinogenesis can be viewed as a multistep process in which the genes controlling proliferation, differentiation, and apoptosis are transformed and altered under selective environmental pressures.

Tumor development involves three distinct, yet closely linked, phases: initiation, promotion, and progression. The initiation phase is a rapid and irreversible event that occurs when a normal cell is exposed to a carcinogenic event. Frequently, unrepairable or misrepaired DNA damage happens in the initiation phase.

Promotion and progression processes are relatively longer processes than the initiation stage, and are considered reversible. Using various animal cancer models, scientists found that all three cancer development stages can be intervened by treatment with natural (or synthetic) chemicals.

Epidemiological and population studies also establish a close relationship between incidence of cancer and consumption of certain types of food.

The term “chemoprevention” was first coined in 1976 by Michael Sporn, when he referred to prevention of malignancy development by vitamin A and its synthetic analogs. Since then, chemoprevention has been adopted as one of the major tactics to modulate the process of carcinogenesis. Many research studies have proven this strategy is effective in reducing the incidence of cancer in well-defined high-risk groups.

Chemoprevention is by definition the use of natural (or pharmacologic) agents to inhibit the development of invasive cancer. The chemicals with a cancer preventive activity are referred to as chemopreventive agents. A chemopreventive agent can inhibit carcinogenesis either by blocking the DNA damage at initiation stage or by arresting or reversing the processes at promotion and progression stages. Most of the chemical substances used in cancer chemoprevention studies are natural phytochemicals found in food.

On the basis of the inhibition stages, chemopreventive agents have been classified into two categories, namely blocking agents and suppressing agents. Blocking agents act by preventing carcinogens from reaching the target sites, from undergoing metabolic activation, or from subsequently interacting with crucial cellular macromolecules such as DNA, RNA, and proteins at initiation stages.

Suppressing agents, on the other hand, inhibit the malignant transformation of initiated cells at either the promotion or the progression stage. Some agents may work on all three stages of carcinogenesis, and are hence classified into both categories.

DIETARY PHYTOCHEMICALS ARE NATURE’S CHEMOPREVENTIVE AGENTS

Many different animal models and cancer cell lines have been used to evaluate the chemopreventive values of phytochemicals, and have led to the discovery of new classes of chemopreventive agents. These agents include isothiocyanates (such as sulforaphane) from cruciferous vegetables, polyphenols from green and black tea, curcuminoids (from turmeric root), stilbenes such as resveratrol (from giant knotweed plant), flavonoids such as quercetin, and anthocyanidins (from many fruits and soybeans).

Progress also has been made in understanding the mode of action of newly identified chemopreventive agents. Exposure to the chemopreventive agents produces certain level of reactive oxygen species (ROS) or electrophiles, and causes mild oxidative/electrophilic stresses in cells.

Ultimate Protector - nrf2 activator

Such mild oxidative stresses are sufficient to initiate the signaling pathways that, in turn, can activate a variety of cellular events, such as induction of phase II detoxification enzymes and antioxidant enzymes, expression of tumor-suppressor genes, and inhibition of cell proliferation and angiogenesis.

In order to survive under a variety of environmental or intracellular stresses, our cells have developed highly efficient protective mechanisms to protect themselves from oxidative or electrophilic challenges. Proteins that comprise phase II detoxification and antioxidant enzymes provide an enzymatic line of defense against reactive oxygen species. These enzymes include superoxide dismutase (SOD), catalase, glutathione peroxidase, glutathione S-transferase (GST), and glutamate cysteine ligase.

Induction of phase II and antioxidant enzymes are regulated at the DNA/gene level by antioxidant responsive element (ARE). ARE-mediated gene expression plays a central role in the cellular defense against cellular oxidative damage.

Experimental evidence supports the view that induction of ARE-mediated cytoprotective enzymes is a critical and sufficient mechanism to enable protection against carcinogenesis provoked by environmental and endogenous insults.

One of the key ARE-binding transcription factors is Nrf2. Induction of cytoprotective enzymes in response to ROS, electrophiles, and chemopreventive agents is a cellular event that is highly dependent on Nrf2 protein.

Nrf2 BOOSTS CELL DETOXIFICATION AND ANTIOXIDANT ENZYMES

By activating Nrf2 signaling, chemopreventive agents can increase cellular detoxification and antioxidant enzymes, thereby enhancing removal of reactive carcinogens and blocking carcinogenesis. This hypothesis has been tested in many studies.

For example, a study with sulforaphane (an isothiocyanate present abundantly in cruciferous vegetables) has shown that oral administration of this phytochemical could effectively block benzo[a]pyrene-induced forestomach tumors in mice. This protective effect was abrogated in mice that could not produce Nrf2, supporting a critical role of phase II detoxification and antioxidant enzymes in the prevention of carcinogenesis by chemopreventive agents.

Nrf2 is normally bound in the cytoplasm of cells to a protein called KEAP1. However, when an appropriate phytochemical agent attaches to a kinase receptor on the cell wall a phosphate group is released that causes the Nrf2 to be released. The Nrf2 then migrates into the cell nucleus and causes an antioxidant enzyme, such as SOD, to be released. This endogenously produced enzyme then can protect against ROS, electrophiles, and chemopreventive agents.

In practice, it has been found that a combination of multiple polyphenols works significantly better than single ingredients at activating Nrf2. In fact, in one experiment it was found that a combination of five ingredients all known to be Nrf2 activators was 18 times more effective than any single ingredient. Furthermore, it was found that this combination of five ingredients  increased levels of SOD by 30% and catalase by 56% after 120 days.

ULTIMATE PROTECTOR
A POWERFUL, NATURAL Nrf2 ACTIVATION FORMULA FOR GREATER HEALTH

In view of the above information, we have developed an exceptional formula designed to maximize activation of Nrf2 in the body. This new product is ULTIMATE PROTECTOR. It is among the most advanced, natural Nrf2 activator formula on the market today.

We include a broad range of Nrf2 activators in ULTIMATE PROTECTOR. These activators source from a wide variety of freeze-dried and concentrated fruits, vegetables, and herbs. These include Wild Blueberry, Wild Bilberry, Acai, Black Currant Extract, Sweet Cherry, Raspberry, Elderberry, Blackberry, Aronia, Black Soybean Hull Extract, Blue Corn, CoffeeBerry, Curcumin (standardized extract with 95% curcuminoids from Turmeric), Glutathione (reduced), Trans-Resveratrol (98% from Giant Knotweed),Grape Seed, Cranberry, Tart Cherry, Prune, Raspberry Seed, Strawberry, Quercetin, Broccoli, Broccoli Sprouts, Tomato, Kale, Carrot, Brussels Sprouts, Onion, and Spinach.

Phytochemicals provided by the array of freeze-dried and concentrated fruits, vegetables, and herbs in the formula include: Polyphenols, Phenolic acids, Anthocyandins, Sulforaphane, Glucosinolates, Lutein, Lycopene, Beta Carotene, Chlorogenic acid, Ellagic acid, Quercetin, Quinic acid, Proanthocyanidins, Trans-Resveratrol, Ferulic acid, Caffeic acid, and Polysaccharides.

In addition to these Nrf2 activators (above), ULTIMATE PROTECTOR contains an extremely broad array of plant based antioxidants from the same sources described above, as well as from non-GMO Vitamin C from cassava / tapioca. All ingredients in this product have been used in chemoprevention protocols, as well as in protocols aimed at preventing free-radical damage in the body.

Ultimate Protector is now available on the HPDI website!

 Fruit

REFERENCES

“Resveratrol induces glutathione synthesis by activation of Nrf2 and protects against cigarette smoke-mediated oxidative stress in human lung epithelial cells.”  Am J Physiol Lung Cell Mol Physiol 294: L478–L488, 2008.

“Nrf2 as a master redox switch in turning on the cellular signaling involved in the induction of cytoprotective genes by some chemopreventive phytochemicals.” Planta Med. 2008 Oct; 74(13): 1526–39. Epub 2008 Oct 20.

“Nrf2: a potential molecular target for cancer chemoprevention by natural compounds.” Antioxid Redox Signal. 2006 Jan–Feb; 8(1–2):99–106.

“Cancer chemoprevention by phytochemicals: potential molecular targets, biomarkers and animal models.” Acta Pharmacol Sin. 2007 Sep; 28(9): 1409–21.

“Natural dietary anti-cancer chemopreventive compounds: redox-mediated differential signaling mechanisms in cytoprotection of normal cells versus cytotoxicity in tumor cells.” Acta Pharmacol Sin. 2007 Apr; 28(4): 459–72.

“Anticarcinogenesis by dietary phytochemicals: cytoprotection by Nrf2 in normal cells and cytotoxicity by modulation of transcription factors NF-kappa B and AP-1 in abnormal cancer cells.” Food Chem Toxicol. 2008 Apr; 46(4): 1257–70. Epub 2007 Sep 15.

“Signal transduction events elicited by cancer prevention compounds.” Mutat Res. 2001 Sep 1; 480–481: 231–41.

“Targeting specific cell signaling transduction pathways by dietary and medicinal phytochemicals in cancer chemoprevention.” Toxicology. 2010 Dec 5; 278(2): 229–41. Epub 2009 Oct 20.

“NF-kappa B and Nrf2 as potential chemopreventive targets of some anti-inflammatory and antioxidative phytonutrients with anti-inflammatory and antioxidative activities.” Asia Pac J Clin Nutr. 2008; 17 Suppl 1:269–72.

“Regulation of NF-E2-Related Factor 2 Signaling for Cancer Chemoprevention: Antioxidant Coupled with Antiinflammatory.” Antioxid Redox Signal. 2010 Dec 1; 13(11): 1679–98. Epub 2010 Aug 17.

“Molecular targets of dietary phenethyl isothiocyanate and sulforaphane for cancer chemoprevention.” AAPS J. 2010 Mar; 12(1): 87–97. Epub 2009 Dec 15.

“Dietary chemopreventive compounds and ARE/EpRE signaling.” Free Radic Biol Med. 2004 Jun 15; 36(12): 1505–16.

 “Multiple molecular targets in cancer chemoprevention by curcumin.” AAPS J. 2006 Jul 7; 8(3): E443–9.

ADDITIONAL RESOURCES

Ultimate Protector™

Questions & Answers about Ultimate Protector

Ultimate Protector Design Considerations – by Dr. Hank Liers

The Amazing Healing Potential of Natural Nrf2 Activators – by Dr. Hank Liers

Ultimate Protector™: First Impressions  – by Dr. Hank Liers

Ultimate Protector™ ORAC5.0™ Test Results  – by Dr. Hank Liers

Preventing Free-Radical Damage Using Ultimate Protector™ – by Dr. Hank Liers

New Directions for Preventing Free-Radical Damage  – by Dr. Hank Liers

Description and Comparison of ORAC Tests for Well Known Plant Ingredients and Ultimate Protector™ – by Dr. Hank Liers

Ultimate Protector and the Role of Foundational Supplements for Health – by Fred Liers, PhD

Ultimate Protector flyer (.pdf)

Digase™ (Digestive Enzyme Design Rationale) Part 2: the Formula

In Part 2 of the Product Rationale for our Digase™ enzyme formula, we present  both its various components and the functions each performs in the product.

You may also wish to read Part 1 of the Product Rationale.

4.0 THE DIGASE FORMULA

The enzymes and herbs contained in the latest, improved Digase™ formula are shown below:

NUTRIENT AMOUNT† % Daily Value
Amylase 2,500 DU *
Glucoamylase 9 AGU *
Invertase (Sucrase) 200 SU *
Maltase Diastase 500 DPo *
Protease 4.5 8,000 HUT *
Peptidase FP 2,000 HUT *
Protease 6.0 4,000 HUT *
CereCalase™ 7.5 mg *
Protease 3.0 (acid stable) 8 SAPU *
Alpha-Galactosidase 60 GALU *
Lipase 250 FIP *
Cellulase 200 CU *
Lactase 250 ALU *
Caraway Seed (Carum carvi) 70 mg *
Gentian (Gentiana lutea) 70 mg *
Ginger Rhizome (Zingiber officinale) 70 mg *

* No established Daily Value
† Enzyme activity specified according to standard FDA accepted Food Chemical Codex procedures

CARBOHYDROLYTIC ENZYMES

Amylase, Glucoamylase, Malt Distase, Lactase, Invertase, Alpha-Galactosidase, Cellulase and Cerecalase™

Starch is abundant in the natural world where it serves as the primary energy source for plants, animals and humans. Starch consists of glucose polymers. These polymers exist in two basic compositions, amylose and amylopectin. Amylose, the minor constituent, consists of straight chains of glucose joined with alpha-1,4-glucosidic bonds. Amylopectin consists of branched glucose chains. The branching of the glucose chain occurs with the formation of an alpha-1,6-glucosidic bond. The ratio of amylose to amylopectin varies dependent upon the origin of the starch but is typically in the range of 1:3 to 1:4.

Starch digestion is optimized with the combination of the enzymes alpha-amylase, glucoamylase and malt diastase. While alpha-amylase breaks glucose-glucose bonds at random points within the starch chain, malt diastase hydrolyzes the starch chain from the ends to create glucose dimers (maltose) and glucoamylase breaks single glucose molecules off the ends of the chain. The hydrolytic action of both alpha-amylase and malt diastase is blocked by the alpha-1,6-glucosidic bonds of amylopectin.

The conformation of these limit dextrins prevents the active site of the enzymes from coming in contact with the glucose-glucose bonds thus inhibiting hydrolysis. Glucoamylase hydrolyzes the alpha-1,6-glucosidic bond, freeing the chain for continued hydrolysis of the alpha-1,4-bonds. The action of these three enzymes are outlined in the following three figures which clearly show the benefit of combining amylase, malt diastase and glucoamylase for the liberation of glucose.

 

FIGURE 1. Action of Amylase (/) without the presence of Glucoamylase for the hydrolysis of amylopectin (component of starch).

 

 

FIGURE 2. Action of Amylase and Malt Diastase (/) without the presence of Glucoamylase for the hydrolysis of amylopectin (component of starch). Spaces represent sites of Amylase action.

 

 

FIGURE 3. Action of Amylase, Malt Diastase and Glucoamylase (/) for the hydrolysis of amylopectin (component of starch). Spaces represent sites of Amylase and Malt Diastase action. Glu (underlined) represents molecules of free glucose available after hydrolysis is complete.

 

The ratio of amylase and glucoamylase activities is relatively standardized with the data for the development of the ratios being derived from the sugar industry.

The amount of lactase in the product is low in comparison to the original Lactaid® formulation. Individuals who do not have dairy problems are not paying for an expensive enzyme with little direct benefit to them. However, those who are lactose intolerant can increase their dosage with dairy consumption to help prevent their symptoms. In comparison to most other products on the market positioned as general digestive supplements, the proposed product is similar in lactase activity.

In regards to alpha-galactosidase, this enzyme is characterized by its ability to hydrolyze the alpha-1-6 linkages in melibiose, raffinose, and stachyose, sugars commonly found in vegetables especially of the legume and cruciferous families. Taken as a supplement, alpha-galactosidase decreases the incidence of flatulence associated with the consumption of raffinose-containing vegetables. The level of invertase in Digase™ is comparable to other general digestive products.

Cellulase and CereCalase™ enzymes offer distinct advantages for individuals consuming large amounts of grains, beans and other vegetable feedstuffs. These enzymes hydrolyze the bonds in various fibers. Cellulase hydrolyzes glucose-glucose bonds in cellulose. By disrupting the structure of the fiber matrices which envelop most of the nutrients in plants, cellulase increases the nutritional value of fruits and vegetables.

CereCalase™ is a proprietary blend of three enzymes—hemicellulase, beta-glucanase and phytase—that work together to macerate, or disrupt, the cell walls of fruits, vegetables, seeds and herbs. These three enzymes hydrolyze non-starch polysaccharides (NSPs) which can have anti-nutritive effects. NSPs have also been shown to bind digestive enzymes and inhibit mineral absorption.
PROTEOLYTIC ENZYMES

PROTEASE 3.0, PROTEASE 4.5, PROTEASE 6.0 and PEPTIDASE

The complexity of proteins and peptides requires the combination of multiple proteases to optimize digestion. Proteins are made up of over twenty different amino acids with each combination presenting different conformational characteristics. Each proteolytic enzyme has different bond specificities and thus a combination shows the greatest rate of hydrolysis. Bond specificity is an ongoing area of research in enzymology. However little has been done on the various Aspergillus proteases.

Peptidase breaks amino acids off the ends of the peptide chain. Our supplier’s (National Enzyme Company (NEC)) peptidase possesses both amino-peptidase and carboxy-peptidase activities and thereby can remove amino acids from both ends of the peptide chain. Protease 4.5 and Protease 3.0 break at points within the peptide chain dependent upon their bond specificities. While these specificities have not been fully elucidated, significant differences in the action of these enzymes have been seen both in the laboratory and in digestive product usage.

The pH optima and ranges of these two enzymes is also an important benefit of combining these proteases. Protease 4.5 has an optimal pH of 4.5 (pH range 2.0 to 6.0) while Protease 3.0’s optimum is pH 3.0 (pH range 2.0 to 7.0) and Protease 6.0 has an optimal pH of 6.0 (pH range 4.0 to 11.0). Together these proteases provide proteolytic action throughout the human digestive system.
LIPOLYTIC ENZYMES

LIPASE

The lipase included in Digase™ has a very broad range activity and is capable of hydrolyzing all three triglyceryl bonds yielding free fatty acids and glycerol. Many lipases hydrolyze only the 1- and 3-positions. In contrast, the Aspergillus niger lipase is capable of breaking the bonds at all three positions although the 2-position is hydrolyzed at a slightly slower rate.

In addition, our lipase shows an optimum pH of 5.0 with an active range of pH 3.0 to 9.0. The LU level for this formulation is in the middle to high range of modern digestive formulations and is comparable with the level used in current research.
HERBS

Gentian Root (Gentiana lutea), Ginger Rhizome (Zingiber officinale), and Caraway Seed (Carum carvi)

Three herbs have been incorporated into this formula to support the digestive action of the food enzymes. Gentian Root (Gentiana lutea) is a bitter herb which is recognized worldwide as one of the most effective gastric stimulants. This herb is widely used to improve digestion and stimulate appetite as well as being beneficial for all types of gastrointestinal disorders including dyspepsia, gastritis, heartburn, and nausea. Research shows that the bitter principles found in Gentian stimulate gastric secretions and have choleretic activity; substantiating the herbs effectiveness for digestion.

Ginger Rhizome (Zingiber officinale) is an incredibly active and effective gastrointestinal aid with the following properties: 1) Contains a digestive enzyme whose effectiveness even exceeds that of papain, 2) Stimulates the flow of saliva and increases dramatically the concentration of the digestive enzyme amylase in the saliva, and 3) Activates peristalsis and increases intestinal muscle tone.

Caraway Seed (Carum carvi) further supports healthy digestion. This herb has carminative and antispasmodic activities that help to soothe the stomach and ease digestion. Caraway also benefits this formulation by its action to increase digestion of fats. Like Gentian Root, Caraway Seed has also been shown to stimulate the appetite.

5.0 GENERAL NOTE ON ENZYME POTENCIES

Due to the catalytic nature of enzymes, any amount (no matter how small) will increase the rate of reaction. Larger potencies simply serve to increase the rate to a higher level, at least within the kinetic ability of the enzyme. Since these enzymes are safe and non-toxic, high activity levels are more cost- and marketing-driven than scientifically established. A game of “our potencies are higher than theirs” is currently one of the most common marketing ploys.

The area of greatest concern in enzyme formulation is in achieving the proper balance in the enzyme ratios. Broadening the formulation to contain multiple proteases and carbohydrases is a valid way to improve the activity of any product. The benefits relate to the specificity of each enzyme. Since each enzyme catalyzes reactions at different sites, multiple enzymes can quickly increases the rate of hydrolysis and improve the bioavailability of amino acids, sugars and fatty acids.

 

REFERENCES:

Beazell, J.M., “A Reexamination of the role of the stomach in the digestion of carbohydrates and protein,” American Journal of Physiology 132: 42-50 (1941).

Berkow, R.,ed. The Merck Manual, 15th edition, (Rahway, NJ: Merck Sharp & Dohme Research Laboratories, 1987).

Bradley, P.R., ed. British Herbal Compendium, Volume 1, (Dorset, England: British Herbal Medicine Association, 1992).

Cichoke, Anthony J., Enzymes & Enzyme Therapy: How to Jump Start Your Way to Lifelong Good Health, (New Canaan, CT, Keats Publishing, 1994).

Duke, J.A., Handbook of Medicinal Plants, (Boca Raton, FL: CRC Press Inc., 1985).

Ghose,T.K. and Pathak, A.N. “Cellulase-2: Applications” Process Biochemistry, 20-24, May 1973.

Guyton, A.C., Textbook of Medical Physiology, 8th edition. (Philadelphia: W.B. Saunders Company, 1991).

Howell, E, Enzyme Nutrition: The Food Enzyme Concept, (Wayne, NJ, Avery Publishing Group, Inc., 1985).

Lennard-Jones, J.E. “Functional gastrointestinal disorders.” New England Journal of Medicine 308: 431 (1983).

Murray, R.D., et. al. “Comparative absorption of [13C] glucose and [13C] lactose by premature infants,” American Journal of Clinical Nutrition 51: 59-66 (1990).

O’Keefe, S.J.D., et. al. “Milk-induced malabsorption in malnourished African patients,” American Journal of Clinical Nutrition 54: 130-135 (1991).

Prochaska, L.J.; Piekutowski, W.V. “On the synergistic effects of enzymes in food with enzymes in the human body. A literature survey and analytical report.” Medical Hypotheses 42: 355-62 (1994).

Schwimmer, S., Source Book of Food Enzymology, (Westport CT, The AVI Publishing Company, Inc., 1981).

Thacker, P.A.; Campbell, G.L.; GrootWassink, J. “The effect of enzyme supplementation on the nutritive value of rye-based diets for swine.” Canadian Journal of Animal Science 71: 489-96 (1991).

Theiss, B. and Theiss, P., The Family Herbal, (Rochester, VT: Healing Arts Press), 1989).

Weiss, R.F., Herbal Medicine, (Gothemburg, Sweden: AB Arcanum, 1988).

 

APPENDIX A

THE DESIGN MEAL

The following table provides details of the “typical” meal around which the Digase™ formula was designed. Two capsules of the formula provide as much as 80% of the digestive power needed to digest this 1000 kilocalorie, high-fat meal.

 

FOOD COMPONENT % OF MEAL WEIGHT
Animal Protein 12% 50 grams
Vegetable Protein 8% 20 grams
Animal Fat 17.5% 19.5 grams
Vegetable Fat 17.5% 19.5 grams
Carbohydrate 45% 112.5 grams
Fiber (non-digestible) 10 grams

 

APPENDIX B

ORIGINS OF ENZYMES IN THE PATHWAY DIGASE™ FORMULA

 

ENZYME SOURCE
Amylase Aspergillus oryzae ferment
Protease 4.5 Aspergillus oryzae ferment
Protease 6.0 Aspergillus oryzae ferment
Protease 3.0 Aspergillus oryzae ferment
Peptidase FP Aspergillus oryzae ferment
Invertase Saccharomyces cerevisiae
Malt Diastase Hordeum vulgare malt
Lactase Aspergillus oryzae ferment
Cellulase Trichoderma long brachiatum
Lipase 21179 Aspergillus niger ferment
Alpha-Galactosidase Aspergillus niger ferment
CereCalase™ Aspergillus niger ferment
5

Gardening for Super Health

Hank's GardenI love to grow vegetables in my backyard and have been doing so on-and-off for 50 years now. It’s such a pleasure to prepare the soil, plant the seeds/seedlings, tend them as they grow, and finally enjoy the harvest. My thumb is relatively green, so harvests have been plentiful and tasty. Possibly, something rubbed off from watching my father do his gardening. He was a very serious gardener and fed his family from the garden during WWII.

However, during the last 25 years my interest in gardening grew much more focused. As I became a designer of nutritional supplements and had to nourish my wife who had become chemically sensitive, I was keenly aware that the foods and supplements we consume are of the upmost importance.

Due to her chemical sensitivities since 1985, for example, my wife finds it necessary to eat only organically grown foods. The penalty she pays for eating any non-organic foods from the supermarket are severe joint pains all over her body! For years, I travelled 120 miles every Saturday to purchase a week’s supply of organic fruits and vegetables.

I read incessantly to understand how to be truly healthy — and because I was now house chef — how to prepare truly healthy meals. I learned about a place called Findhorn in Scotland where a group of people were growing astoundingly healthy and huge vegetables using special growing methods that I recall included something called “rock dust.”

I later learned from Rutgers University’s Firman E. Baer Report that differences in mineral content in plants grown in “good soil” versus plants grown in “poor soil” are often enormous. That is, plants grown in “good soil” can be 100 times (or more) richer in certain minerals!

After we moved to Southern Arizona in 1993, I heard from a friend about worm beds and castings and started a worm bed in our yard. Shortly thereafter, I purchased a 50 pound bag of rock dust and started using it along with a product called EM (“Effective Microorganisms”) that enhanced the soil with beneficial microorganisms. Our neighbors and gardener found it hard to believe the plants we grew were so healthy and productive! We continued enhancing the soil and enjoyed a highly productive garden for years.

Then in 2009, I built several very large raised beds so that I could control the soil more completely and purchased a 50 pound bag of rock dust (Agrowinn Minerals) from a company in Southern California (www.fertilizeronline.com). Using this rock dust along with plenty of compost I grew amazingly large and healthy vegetables such as zucchini, squash, tomatoes, eggplant, peppers, parsley, etc. I used these vegetables daily in preparing salads, stir fries, soups, and other dishes.

My wife felt so good eating these garden-fresh (and mineral-rich) dishes, she thereafter refused to eat anything except meals prepared from garden produce! Now, something in my head started to churn! Our high quality garden foods make an enormous difference to the person eating them. Everything I’d read and heard about trace minerals is true: our health depends upon it!

In 2011, I hired a new employee (Linda Leigh) who runs a side business (Vermillion Wormery) raising red wiggler worms. I learned from her how to use worm castings tea (and I built another worm bed that effectively recycles all of my organic kitchen wastes). When done correctly, vermicompost tea produces a huge number of aerobic microorganisms that take up nutrients from the soil (including rock dust), and then convert them into organic forms readily available to garden plants.

More recently, I learned that in the aftermath of the Chernobyl nuclear disaster in the Ukraine, dairy cows consuming grass fertilized with rock dust had no radiation in their milk. Yet, cows just down the road eating grass not fertilized with rock dust had radiation in their milk! This indicates when you are replete with the proper amount of trace minerals your body needs, you will NOT absorb minerals of a similar nature that are radioactive (e.g., cesium-137 and strontium-90)!

In these times, when our health is adversely affected by a broad range of environmental, nutritional, and lifestyle factors, it’s important to know you can easily grow your own super healthy foods, especially using the methods I describe (above). Growing your own organic and biodynamic foods is a major step towards creating super health for yourself, as well as for your family, friends, and pets.

As it turns out (not unexpectedly!), another benefit of gardening and farming is better immunity and health through exposure to soil microorganisms. Thus, it appears that in addition to the benefits of eating mineral-rich garden produce, simple exposure to soil microorganisms in “a little dirt” while gardening is itself a very good thing for health! For more information on this subject see our blog article entitled “A New View of the Role of Bacteria in Health“.

 

Note: you may also enjoy my related blog post (from June 14, 2012): Living with Radiation: Protection Starts Today. That post deals with specific measures (diet, supplements, etc.) you can use to protect yourself from radiation.

References:

The best place to buy rock dust and worm castings in the USA:
http://www.fertilizeronline.com/

Here is a place in Scotland that tells their story about rock dust:
http://planetthrive.com/2010/01/transforming-barren-land-into-fertile-ground/

This website is all about remineralization of the earth. Highly recommended!
http://remineralize.org/

Here is an excellent website on worm castings, including worm castings tea:
http://www.mypeoplepc.com/members/arbra/trinity/id14.html

New York Times article on health benefits of exposure to soil microorganisms:
http://www.nytimes.com/2012/06/21/opinion/lets-add-a-little-dirt-to-our-diet.html

For those interested in the details of soil biology, here is an online book on the subject:
http://soils.usda.gov/sqi/concepts/soil_biology/soil_food_web.html