Irena Ossola - Powered by Rejuvenate!

Pro cyclist Irena Ossola – Powered by Rejuvenate!™

HPDI is pleased to announce sponsorship of professional racing cyclist Irena Ossola. Irena races at the elite level as part of International French and Canadian 2017 SAS – MACOGEP Pro Cycling Team. She competes full-time in races all across the United States and Europe. Irena is also a cycling coach, bike tour leader, and a graduate of Columbia University. She regularly trains in Santa Fe, New Mexico and Tucson, Arizona.

Recently, Dr. Hank Liers met with Irena to discuss nutrition for high-performance athletes, and her current experience using Rejuvenate! high-RNA superfoods for cycling performance and recovery. Her plan is to continue using Rejuvenate! superfoods and incorporate additional HPDI foundational supplements into her nutrition program.

Irena initially discovered Rejuvenate! superfoods last year as part of her nutrition regimen. She reported increased energy and faster recovery times using as little as one-scoop of Rejuvenate!™ PLUS and/or Berries & Herbs, which she added to her already “clean” diet. She often would combine 1/2 scoop of each formula into a smoothie consumed after training sessions or races. During periods when she paused her intake of Rejuvenate, she noticed recovery took longer.

After recognizing the competitive advantages afforded her by Rejuvenate! superfoods, Irena has become a convert to a high-RNA lifestyle that includes significant levels of dietary nucleic acids daily from two or more scoops of Rejuvenate! PLUS, Berries & Herbs, or original. With HPDI’s nutritional sponsorship, Irena has been able to increase her intake of HPDI’s unique superfoods.

On Facebook she recently wrote about her consumption of Rejuvenate!™ superfoods:

“I am a full supporter of the Health Products Distributors, Inc. products and using the Rejuvenate! superfoods in my recovery smoothies. I can feel the difference in my workouts and my everyday energy by incorporating them in my already clean diet. This is not just a sponsor testimonial, but honest truth! I raced 3 days last weekend, and have done 5 hard workouts in 7 days and am continually astonished at what my body has been able to do since using the products.”

Irena already feels additional increases in energy and experiences faster recovery times as she boosts her intake of Rejuvenate! superfoods. She also has begun incorporating other foundational supplements like Multi Two (caps), Essential Fats Plus E (essential fats, and Ultimate Protector into her regimen.

We at HPDI are excited that we can contribute to Irena’s nutritional program. We anticipate great things to come! You’ll be hearing much more about Irena and her team in the coming months. Again, we are pleased to officially announce that Health Products Distributors, Inc. now sponsors Irena and her elite level women’s cycling team, Cloud Racing.


For many reasons this is an exciting partnership! I’m sure we’ll blog a lot in coming months about natural nutritional advantages for athletes. But there is another reason to be excited.

Irena is the highlighted in a new documentary titled “She Works,” about women in professional sports.

Because whether its basketball, soccer, or cycling, professional female athletes such as Irena Ossola typically struggle with a lack of promotion and financial support. The “She Works” video documentary project will feature Irena and will raise awareness and hopefully stimulate meaningful discussions about gender inequality in professional sports.

The “She Works” video project has a shoestring budget of $4,500 raised through a 15-day Kickstarter campaign that ended March 28, 2014. Additional funding contributions are welcome. Please contact us at support(at)integratedhealth.com or 520-896-9193.

If you are interested in sponsoring Irena and/or Team Cloud, you can contact her directly at ossola.irena(at)gmail.com or 505-795-6832. Also, please visit her website (www.OssolaSport.com).

Learn more about “She Works.”



irena ossola rejuvenate superfoods

Irena in Southern California for the San Dimas and Redlands Classic stage races. She claimed 30th place in in the General Classification in San Dimas, including 10th overall in the Circuit Race.


irena ossola professional cycling rejuvenate superfoods foundational supplements integratedhealth

A few of the supplements we provide to Irena. She is ‘powered by Rejuvenate!™’ and other foundational supplements, which are an important part of her nutrition program.


Irena Ossola’s page on the HPDI website: www.integratedhealth.com/irena-ossola-products.html

Irena’s personal website and blog: www.OssolaSport.com

Irena’s Facebook page

Irena’s Instagram page

“She Works” Documentary Film Project at Kickstarter.com: www.kickstarter.com/projects/831264978/she-works



Fred Liers PhD dietary nucleic acids doctor benjamin s frank RNA No-aging dietIn Part One of this article, I introduced the work of Dr. Benjamin S. Frank. Specifically, I presented information about his groundbreaking research and unique contributions to our understanding of the health benefits provided by dietary nucleic acids.

In this article I discuss the mechanisms by which Dr. Frank proposes dietary nucleic acids support metabolic processes in the body and promote optimal health. I will also consider the dietary recommendations he presents in his No-Aging Diet in the context of current knowledge regarding dietary nucleic acids (i.e., RNA, DNA, nucleotides, and nucleosides).

Dr. Frank wrote at least four books about dietary nucleic acids, including Dietary Nucleic Acid Nutrition and Therapy and his popular bestseller Dr. Frank’s No-Aging Diet: Eat and Grow Younger (1976). In these works, he describes the results of his studies of the effects of dietary nucleic acids in humans and animals. He also reports his observations of his patients who were placed on high-RNA diets or who were given RNA extracts.

Dr. Frank’s contributions to the study of dietary nucleic acids for health include the following highlights:







Dr. Frank’s books make for enlightening reading. This is especially the case for anyone seriously interested in optimal health, anti-aging, healing and recovery, athletic performance, life extension, or for developing nutrition protocols for individuals who desire benefits in these areas.

In fact, I highly recommend reading at least Dr. Frank’s No-Aging Diet. It captures the essence Dr. Frank ‘s mission to help people apply then-current knowledge to gain health benefits from dietary nucleic acids. It is easy to read and intended to be highly accessible. It remains out of print, but copies are still available at low cost because it was a bestseller.

After reading it, if you’re still interested in learning more (or more than you ever thought possible) about dietary nucleic acids, then read Nucleic Acid Nutrition and Therapy. This one will cost you since it’s out of print, and it was originally published in limited quantities.

Nucleic Acid Nutrition and Therapy is worth keeping because it holds highly technical information available nowhere else. Plus, it can’t be beat as a reference. On the other hand, you may feel compelled to head back to graduate school to earn a PhD in molecular biology just to fully comprehend it. Don’t let the feeling deter you. Persist and power through it. You’ll catch just enough to grasp the real genius of Dr. Frank.


Dr. Benjamin S. Frank proposed nucleic acids are essential nutrients.


Speaking of genius, Dr. Frank left no stone unturned in his investigations in the biological effects and benefits to health of dietary nucleic acids. Here are five of the major health building, rejuvenating, and anti-aging effects of dietary nucleic acids he reports:







This is a just a partial list of beneficial effects. Dr. Frank reports plenty more. Other effects include greater functional strength, lower cholesterol levels, improved cardiovascular function, improved circulation (including beneficial effects for individuals suffering from circulation problems due to diabetes), and greater endurance.

We may wonder at how dietary nucleic acids exert this wide range of beneficial effects. Fortunately for us, Dr. Frank was a keen observer of physiological effects (perhaps because he was both a researcher and physician who examined patients). He also had the scientific background that allowed him to propose likely mechanisms of action behind the effects he observed in patients and subjects given dietary nucleic acids.

In his books, Dr. Frank describes how dietary nucleic acids boost cellular production of ATP (adenosine triphosphate) which provides cells with more energy. This energy in turn translates not only into greater energy for fulfilling biological functions from cellular communication to detoxification. It also means greater amounts of energy, endurance, and go-power for individuals consuming nucleic acids.

For additional considerations regarding the mechanisms of operation, production of cellular energy (ATP), descriptions of the full range of health benefits nucleic acids provide, and his theories of aging, see Dr. Frank’s technical book Nucleic Acid Nutrition and Therapy. You can also read my previous blog articles, such as Part 1 of this article and “9 Things to Know about Rejuvenate!™ Superfoods.”


Dr. Frank’s No-Aging Diet, a bestseller in 1976.


Dr. Frank devotes the first chapter of Dr. Frank’s No-Aging Diet to providing examples of “walking miracles,” i.e., people whose experiences using dietary nucleic acids make them living testimonies to the power of high-RNA diets. His next two chapters establish his basic theory of aging and how it relates to dietary RNA.

As I noted earlier, Dr. Frank essentially describes how aging is caused and accelerated by loss of energy (as ATP or adenosine triphosphate) in cells. Dietary nucleic acids boost the body’s production and supply of ATP, thereby improving cellular function and extending life, as well as bettering a person’s quality of life (14–23).

Dr. Frank stood little to gain financially from sharing his knowledge about dietary nucleic acids. That is, apart from book royalties and minor fame as an author. Moreover, he had no ties to any products or the fishing industry. Yet, it is clear that he felt it was important to translate his theoretical and experimental knowledge into practical recommendations from which everyone could benefit.


Dr. Frank presents his actual “No-Aging” diet in chapter four. He lays down “12 rules” in this chapter (26–27). The first four rules involve consuming seafoods.

His first rule: “Four days a week, eat a three- or four-ounce can of small sardines.” The second rule is to have salmon (fresh or canned) as a main course one other day of the week. Rule three is having shrimp, lobster, squid, clams, or oysters as a main course on another day. Rule four is eating a different type of fish on the remaining day. That makes eating seafood de rigueur seven days a week!

Dr. Frank’s diet is often referred to as the “fish diet” or even the “sardine” diet. And that’s for good reason. Consuming seafood daily pretty much amounts to a fish diet. Here’s your weekly menu: Sardines four times, salmon once, non-vertebrate seafood (e.g, squid or shrimp) once, and then another kind of fish. That’s an extremely high frequency of consuming sardines and other types of fish even for seafood lovers.

Not to mention the boredom factor. Fish fillets, steamed fish, grilled fish, baked fish, seafood salad, sushi, etc. There are many ways to prepare it, but it’s still fish. Don’t get me wrong. I enjoy seafoods. But maybe once or twice weekly, not daily. And I’m careful to obtain wild-caught seafoods that are responsibly caught and/or harvested.

That’s getting harder to do even though certifications from organizations like the Marine Stewardship Council (MSC) are increasingly available. As I mentioned, the problem of overfishing remains. There also exists the real possibility of genetically modified fish (which already exist) contaminating wild populations. That would be a big loss for biodiversity among many other problems, including potentially adverse health effects.

salmon fillet dietary nucleic acids RNA no-aging diet Dr. Benjamin S. Frank


There are other critical considerations to consuming fish that go beyond obtaining high levels of nucleic acids.

Consider daily news about mercury- and chemical-tainted fish, ocean oil spills (think BP), radiation contamination of ocean waters (think Fukushima), and other sorts of adverse environmental impacts on ocean fish. Not to mention overfishing and depletion of many types of oceanic species.

Reality intrudes. I’m not convinced eating fish daily is desirable either for human health or the environment. In fact, I’m not sure most people today would be willing to follow a fish-based diet even if there weren’t contamination issues. (Nor would it be good for their health or the environment if they did.)

That’s not to fault Dr. Frank. As he says, “the diet works.” But back in 1976 the oceans weren’t quite as overfished or as polluted as they are today. Moreover, the level of awareness of these issues wasn’t where it is now. But even then, how many people (besides fishermen) could be expected to maintain a fish diet? No doubt, a few people stuck with it.

sardines dietary nucleic acids RNA fish diet

Sardines provide very high levels of dietary nucleic acids.

Today’s issues of overfishing and contamination beg the question of whether we have the knowledge necessary to manage fish populations. Apparently, science is discovering that populations of fish species (even sardines) thought to be plentiful are vulnerable to severe population declines. These may be cyclical, but overfishing could be enough to push these populations over the edge.

The graphic below shows the decline of one genus of sardines, Sardinops. There are other sardine genera (e.g., Sardina, Sardinella) now accounting for a majority of the global catch, but this data indicates that overfishing can contribute significantly to population decline.

global capture of sardines dietary nucleic acids RNA fish

Global capture of sardines in the Sardinops genus in tons, 1950–2010, as reported by the FAO. Based on data sourced from FAO Species Fact Sheets.

Note: The situation may be somewhat different for certain aboriginal peoples (e.g., Eskimos or Polynesians) whose traditional diets are high in fish and other marine foods. For such peoples, consuming seafood-rich diets may be more of a choice than in the past. Yet, for many it remains a way of life despite global overfishing and contamination with pollutants as varied as heavy metals (e.g., mercury) and radiation throughout the Pacific Ocean from the Fukushima nuclear plant.


Then there’s rule five: eat calves’ liver once per week. It turns out that calf liver and other organ meats (like chicken liver, beef heart, etc.) provide high levels of dietary nucleic acids. Dr. Frank points out that organ meats are ideal to consume (in addition to the basic fish diet), especially when compared to muscle meats (like steak or chicken breast), which are not significant sources of nucleic acids.

Certain people enjoy organ meats. I can’t say I enjoy them regularly. It is notable that organ meat consumption has declined for many years. Perhaps due to low demand, they are cost-effective foods in terms of how much RNA they provide for their price. (I routinely see $2.99 organic chicken livers at my local natural foods market. That’s per pound.)

Organ meats contain lots of dietary RNA. But liver, for example, is a detoxification organ. Unless you know the source is pure (or you don’t mind taking your chances), it would be wise not to overindulge. Think free range, organic, cruelty-free, and sustainably raised.


Rule six is to eat beets or beet juice once or twice per week. Rule seven is have a side dish of lentils, peas, lima beans, or soybeans once or twice a week.

Except for maybe soybeans (i.e., it’s hard to find them non-GMO these days), rules six to eight are simple to follow for most people. Unless you dislike beets or lima beans (butter beans). Personally I relish beets and beet juice, and most types of beans.

Beans are in fact among the highest foods in nucleic acids. That’s why Dr. Frank includes them in his list. If you don’t like seafoods or organ meats, beans can be your “go-to” food for RNA. Plus, there’s lots of variety among beans. They’re inexpensive, easy to obtain, store well, and readily available organic. You can even grow your own. I often grow tepary beans here in southern Arizona.

Speaking of beans, Dr. Frank reserves an entire chapter in the book to discuss vegetarian option for the no-aging diet. I’ll talk more about that later.

Rule eight is to eat at least one of the following daily: asparagus, radishes, onions, scallions, mushrooms, spinach, cauliflower, or celery. Most of these vegetables provide dietary nucleic acids. Others (i.e., cauliflower and celery) contain substances supporting the body’s utilization of RNA or other important nutrients. Most people can eat at least one of them daily.

scallions dietary nucleic acids RNA Dr. Benjamin S. Frank no-aging diet

Onions and scallions are tasty and provide dietary nucleic acids.


Rule nine is to take one “strong multivitamin after any meal” every day. This is an important rule for Dr. Frank. His insistence that individuals take a high-potency multivitamin shows that he was ahead of his time, as several authors have noted, including Dr. Ward Dean.

I don’t find Dr. Frank’s insistence of multivitamins to be outlandish. In fact, if anyone could see the benefits of high-potency multivitamins, one might expect it to be a molecular biologist like Dr. Frank who saw firsthand in the laboratory and with his patients the beneficial effects vitamins exerted on their health.

We at HPDI applaud Dr. Frank’s understanding that high-potency multivitamins can be important for health. We have pioneered a system of daily supplemental nutrients we call foundational formulas that include multivitamins. Click here to learn more about the HPDI system of foundational supplements.

dietary nucleic acids RNA rejuvenate superfoods

HPDI foundational supplements: multivitamins, antioxidant formulas, essential fats & Rejuvenate!™ superfoods

Dr. Frank was ahead of his time in other ways, too. For example, he makes a dietary recommendation to consume organically grown foods:

“…to be on the safe side I would avoid foods that are chemically grown and prepared. Chemical fertilizer use depletes the soil of trace minerals which are vital to health. Other chemicals used in food preparation are not natural to the body and may be harmful. Besides, organic foods taste better” (28)

Suffice it to say that when reading Dr. Frank’s books, I come across a fair number of dietary recommendations that many people take for granted today as beneficial. Most of his recommendations in hindsight were ahead of their time given how far outside the mainstream they were back in 1976.


The final three rules involve daily intake of fluids. Dr. Frank advises to drink a glass of fruit or vegetable juice (rule 10), two glasses of milk (rule 11), and four glasses of water (rule 12). I personally find water and vegetable juices easy to drink daily. Milk? Not so much.

Dr. Frank emphasizes fluids while on diet because high nucleic intake potentially can acidify the body and create problems with acidosis, including acidifying body fluids. Maintaining high fluid intake ensures the body stays pH balanced and/or more alkaline. Dr. Frank states that you can fall off the diet once in a while, but that fluid intake should remain high. So fluid intake is important when following a no-aging type diet.

That’s it. Just twelve simple rules that encompass the complete dietary approach to obtaining nucleic acids for their rejuvenating health benefits.


To his credit, Dr. Frank understood that vegetarians require their own version of the no-aging diet that could provide high levels of dietary nucleic acids from vegetable sources.

He devotes chapter 13 to providing “A No-Aging Diet for Vegetarians.” The vegetarian version of the no-aging diet essentially replaces fish and seafoods with legumes as they main source of dietary nucleic acids.

The basic rule is that each meal must include at least one of the following combinations: 1) grains with milk products, 2) legumes (e.g., beans, peas, lentils) with grains, and 3) nuts and seeds with legumes.

Dr. Frank also separately lists nine additional rules for strict vegetarians who consume no fish. These rules center around consuming additional quantities primarily of the vegetables he already mentions in the regular no-aging diet. That is, more asparagus, mushrooms, beets, and greens (e.g., collards, spinach, and turnip greens).


Legumes (e.g., beans, lentils, peas) offer high levels of dietary nucleic acids.

He notably includes a recommendation to drink at least two glasses of milk daily. Milk is not high in dietary nucleic acids, but Dr. Frank must have felt it would provide additional amino acids that could not be provided well by vegetables.

I don’t see precisely why Dr. Frank considers milk to be vegetarian, but back in 1976 I suppose vegetarians might be presumed to be “ovo,” “lacto-” or “ovo-lacto” vegetarians. At least much more so than today, when strict vegetarians do not consume milk or eggs. Indeed, veganism has become a viable option for many individuals interested in consuming a 100% plant-based diet.

Dr. Frank is careful to explain that a therapeutic-strength multivitamin is an “absolute must” for vegetarians, especially given their needs for B vitamins, and particularly vitamin B12 (75).


One of the handiest features of Dr. Frank’s No-Aging Diet is the table in Chapter 14 titled, “Make Up Your Own No-Aging Diet.” The table (“Nucleic Acid Content of Foods”) estimates the approximate amounts of dietary nucleic acids in a variety of foods based upon their purine content. It presents relative amounts numerically terms of milligrams per 100 grams (at least that makes the most sense given the availability of accurate data about dietary nucleic acids today).

The table shows at a glance that chicken livers provide 402 mg of RNA, canned sardines 590 mg, and pinto beans 485 mg (per 100 grams). It is clear that legumes are nearly as plentiful sources of dietary nucleic acids as fish and organ meats. However, the specific types of nucleic acids are not listed.


Dr. Frank’s No-Aging Diet broke new ground. As I said, he was the first to turn laboratory results from his studies of nucleic acids into practical dietary recommendations anyone could follow. He deserves a huge amount of credit. Perhaps even a Nobel Prize.

In my opinion, the approach he presents remains revolutionary not only because Dr. Frank remains the only person ever to popularize a diet high nucleic acids. Think about it.

Nonetheless, Dr. Frank’s fish diet came and went. Certainly more fish are consumed today than in the 1970s or 1980s, and primarily for health reasons. Specifically, people see fish as healthier than red meats and as a good source of omega-3 fatty acids. Note that generally speaking this higher fish intake does not relate to interest in boosting intake of dietary nucleic acids or to having read or heard that Dr. Frank recommended fish for dinner. (His books are no longer in print and they haven’t been for decades, but they are available inexpensively through used booksellers.)

In any event, fish can be important part of a high-RNA diet. As noted, sardines are an excellent food. They provide the highest levels of nucleic acids of all animal foods. They also provide important vitamins (e.g., vitamin D), minerals, and essential fatty acids (omega-3s). Sardines are low on the food chain and therefore are lower in toxins like heavy metals and PCBs than larger fish, such as tuna.


What Dr. Frank did not know is that there are foods providing higher levels dietary nucleic acids than fish. Specifically, chlorella.

Chlorella provides at least 10 times more dietary nucleic acids than sardines. No doubt Dr. Frank would be astounded by this fact, and would have had much to say about it. Unfortunately, the discovery that chlorella contains so much RNA was not widely known in the 1970s.

Dr. Bernard Jensen was the earliest popularizer and champion of chlorella as a source of dietary nucleic acids in recent times. He began researching chlorella in the early 1980s. He published his major work Chlorella: Gem of the Orient in 1987. Dr. Jensen had actually written a book on chlorophyll in 1973. But it took a decade before his interest in chlorella led him to visit a plant in Taiwan, and pursue the the study of chlorella.

Other researchers had shown interest in chlorella in the 1940s and 50s, but primarily for its nutritional content (proteins, fats, and vitamins) and chlorophyll. It was studied by Europeans during second World War as a potential food source, and later by US researchers (including Stanford Research Institute).

Melvin Calvin’s study of chlorophyll in chlorella led to his discovery of the process of photosynthesis (specifically the Calvin Cycle), and he won the 1961 Nobel Prize in Chemistry. Yet, dietary nucleic acids were not a significant part of the research into chlorella. And chlorella was never significantly tapped in the West for its nutritional value.

By the 1970s, the greatest production was in the East Asian nations, primarily Japan and Taiwan, where it was recognized for its nutritional value and healing capabilities.

In recent years chlorella has becomes something of a sensation in the health food and raw food communities. And there is evidence that it is going mainstream, much as it already has in places like Japan, where up to 60% of the population takes it daily.

chlorella dietary nucleic acids RNA

Chlorella contains the highest levels of dietary nucleic acids among foods.


The benefits provided by chlorella are similar to those provided by other high-RNA foods and superfoods. I have discussed these at length in other blog articles and product pages. Certainly not all nucleic acids are the same, and to some degree different types of nucleic acids provide their own unique benefits. We at HPDI believe, as did Dr. Frank, in a dietary approach that emphasizes foods over formulas that provide organ-specific types of nucleic acids.

In any event, chlorella provides extremely high levels of nucleic acids. It is a great food to have available. We have found that nothing beats chlorella for pure nucleic acid power. That is, we respect its capacity to provide RNA at therapeutic levels.

We found that chlorella has a few drawbacks. First, it’s amazingly high nucleic acid content combined with its chlorophyll content, and the unique capacity of its cell wall to latch onto toxins (like heavy metals) makes it an excellent detoxifier. In fact, the cell wall of chlorella is a powerful detoxifier all by itself independent of its nucleic acids. In some ways, this characteristic is a double-edged sword (so to speak).

The unique combination of nucleic acids, chlorophyll, and its cell wall creates the possibility that a person can detoxify too rapidly. Many people hold high levels of toxins in their bodies. Chlorella will pull out those toxins faster than almost any other natural food or substance. When the rate of detoxification exceeds the body’s capacity to process toxins, the result can be detox reactions. While these reactions may (or may not) last long, they can be uncomfortable. Like skin rashes, headaches, fatigue, or even fever.

This means it’s best to start taking chlorella in very small amounts, and then to build up gradually. But this can limit your intake of dietary nucleic acids at a time when you can benefit from higher levels of them were it not for the detoxifying effects of chlorella’s cell wall.

Then there’s the taste. It can be a little intense. A bit oceanic or fishy. I personally enjoy the taste of chlorella. I’ve had years to adjust to it. I’m already detoxified, although I often take chlorella (which is the main ingredient in Rejuvenate! original) to maintain my state of detoxification. I’ve also learned how to combine it with fruits, fruit juices (like lemon or lime juice), and other ingredients to create smoothies that improve its taste. This is especially the case when I desire a smoother, creamier texture or sweeter flavor.

I know plenty of people who can’t take chlorella due to its taste. Or who must moderate their intake. I also know certain individuals who just cannot stomach it. This may be due to taste or perhaps its detoxifying powers, or some other intangible factors.

Even I like to change up my superfoods. That is, despite the fact I enjoy the taste of chlorella, and I have developed ways to combine it (e.g., in smoothies and blender drinks) with many other ingredients from raw berries and fruits to avocados and nuts, I still enjoy other high-RNA foods and superfoods. These include Rejuvenate!™ superfoods, which are my favored means to consume dietary nucleic acids.


Dr. Hank Liers formulated the Rejuvenate!™ line of superfoods in order to provide high levels of dietary nucleic acids in convenient, easily consumed powder forms that are highly pleasing to the taste. Other benefits include slower rates of detoxification, built-in complementary nutrients (like d-ribose, vitamins, and essential fats), and even a version for individuals who do not like greens.

Rejuvenate superfoods comparison page

The Rejuvenate! line of superfoods: Berries & Herbs, Original, and PLUS.

We initially formulated Rejuvenate!™ original as a means to leverage all the advantages of chlorella (60% of this formula) while including ingredients that increase the amount of dietary nucleic acids, as well as nutrients supporting their uptake and utilization. Rejuvenate! original is sort of this perfect mix of nucleic acids, greens (chlorella and spirulina), essential fasts, and supporting nutrients like d-ribose (which is the rate-limiting natural sugar for the uptake of nucleic acids, being the backbone of RNA).

Rejuvenate!™ remains our most potent high-RNA superfood in terms of the amount of dietary nucleic acids unit weight. This means it is highly cost effective, and with 42 servings per container it can provide a daily dose of 340 mg of dietary RNA for six weeks! It is most popular among our most health-conscious customers and “health foodies” and other purists who want maximum greens along with their nucleic acids. (Note that all Rejuvenate! superfoods provide 340–390 mg RNA per serving, but that the serving size varies to some degree.)

Rejuvenate! original High RNA Superfood

Rejuvenate! (original) superfood provides 340 mg of dietary RNA per 12 gram serving (2 tablespoons) and 42 servings per container!

While Rejuvenate!™ original is most popular among our most ardent customers, we eventually discovered that for many people it could offer too much detoxifying power. That is, at least initially before their body adjusted to it. It is similar to straight chlorella in this respect. This issue combined with the the fact that for certain individuals the taste could be too strong sent us back into design mode.

Dr. Hank then formulated Rejuvenate! PLUS. It is about one-third original Rejuvenate! in its composition. This gives it greens and detoxifying power. But it moderates the rate of detoxification. It also creates a lighter texture and a slightly sweeter taste. Hence, we call it our “sweet greens” superfood formula.

Rejuvenate! PLUS has become our most popular superfood. It provides the same amount of dietary nucleic acids per serving as the original Rejuvenate! superfood. But it also offers high-quality plant protein, a built-in multivitamin (with coenzyme B vitamins), and additional synergistic nutrients. For all these reasons, it is our most balanced superfood in the opinion of many. I myself take it daily.

Rejuvenate! PLUS is especially enjoyed by athletes and individuals who participate in sports or outdoor activities. These persons notice a difference in their energy levels, endurance, recovery, and sports performance. See my article, “Dietary RNA for Athletic Performance” for additional information on the effects of dietary nucleic acids on exercise performance.

rejuvenate plus superfood RNA

Rejuvenate! PLUS superfood provides dietary nucleic acids, high-quality plant protein, essential fats, a built-in multivitamin, and more.

There for quite a while, we didn’t think there was any need to formulate additional superfoods beyond Rejuvenate!™ Original and Rejuvenate!™ PLUS. Most of our customers were highly satisfied with them. But we kept hearing from a certain segment of people that they wanted variety and from others we learned they couldn’t stomach any level of greens. So, we went back to the drawing board for more design work.

Hank then formulated Rejuvenate! Berries & Herbs. Rejuvenate!™ Berries & Herbs contains no greens. That’s a loss, for sure. But he made up for it by packing it with organic berries, which give it a very high ORAC value and act as powerful Nrf2 activators.

Secondly, this formula would have to taste great to satisfy the requirements of individuals who couldn’t take greens and/or who wanted variety. And it does taste great! In fact, most people tell us that it’s the best tasting of all the Rejuvenate! superfoods. I have to agree. While I swear by my love for Original and PLUS, both of which I take daily, I will not dispute the fact that Berries & Herbs trumps them when it comes to pure taste!

Hank then added an herbal cell support complex that’s hard to describe, but which is formulated to offer cells the highest levels of protection for optimal health. You can read the ingredients on the label to get some idea of how it works. Suffice it to say that the ingredients in this sub-formula include herbs known for supporting immunity, promoting normal growth patterns, and keeping cells in working order.

Rejuvenate!™ Berries & Herbs is a formula unto itself. That is, there is nothing like it anywhere. I don’t personally take it every day, but certainly more than several times per week. It also goes especially well into fruit-smoothies and blender drinks. I have no problem whatsoever downing delicious smoothies with PLUS and Original. But as the warmer weather approaches in Spring, I find myself reaching for good ‘ol Berries & Herbs. I even love it mixed directly into my fresh organic vegetable juices. How’s that for taste!

Rejuvenate! Berries & Herbs

Rejuvenate!™ Berries & Herbs contains no greens, but includes RNA, cell-protective herbs, antioxidants, multivitamin & plant proteins.

That’s my rundown on HPDI’s line of Rejuvenate! superfoods, which to this day remain the only superfoods formulated specifically to provide high levels of dietary nucleic acids for optimal health and healing, and even improve athletic performance.

I certainly hope you give Rejuvenate!™ superfoods a try if you haven’t already. They offer unparalleled benefits for your health, great taste, and an opportunity for you (and your loved ones) to gain real results from functional superfoods that do more than offer promises.

Click here to learn more about Rejuvenate™ superfoods.


To say we at HPDI are grateful to Dr. Frank for his deep understanding of dietary nucleic acids is an understatement. To say that his understanding of nucleic acids is the foundation of our line of Rejuvenate!™ superfoods is not.

We can’t grant Dr. Frank a Nobel Prize posthumously. But we do wish he could see our Rejuvenate!™ superfoods, which we dedicate to his legacy. And of course, we hope he would have liked them enough to put them in his smoothies!


The Problem of Age, Growth and Death. C.S. Minot. Putnam’s Sons, 1908.

“On the influence of nucleic acids of various origin upon the growth and longevity of the white mouse.” T. Brailsford Robertson. Australian J. Exp Biol Med Sci, 1928, 5: 47–67.

“The effect of yeast nucleic acid on the survival time of 600 day old albino mice.” Thomas Gardner. J Gerontol, 1946, 1: 445–456

“Prolongation of the life span in rats.” Max Odens. J. American Geriatrics Soc., 1973, XXI: 450–451.

It’s Okay to Eat Sardines…Right? Mother Jones Magazine. April 2012.


Dr. Frank’s No-Aging Diet: Eat and Grow Younger. Dial Press, 1976.

Nucleic Acid Nutrition and Therapy. Rainstone Publishing, 1977

Nucleic Acid and Anti Oxidant Therapy of Aging and Degeneration. Royal Health Books, 1977.

Nucleic Acid Therapy in Aging and Degenerative Disease–A Metabolic Approach with DNA, RNA, and Related Metabolites. Psychological Library, 1968.


Ribonucleic Acid Part One: A Highly Effective Anti-Aging Supplement by Ward Dean

Ribonucleic Acid Part Two: Review of Potential Anti-Aging Effects by Ward Dean

Ribonucleic Acid Part Three: Potential Therapeutic Uses: Review of Clinical Experience with RNA by Ward Dean

Revisiting a Scientist’s Work: New Studies Reinforce Older Ones…RNA Therapy May Slow Down Aging by Jeffrey Laign




High-RNA Rejuvenate! Superfood by Hank Liers, PhD

9 Things to Know about Rejuvenate!™ Superfoods by Fred Liers, PhD


Super-Tasty Morning Nutritional Drinks by Dr. Hank Liers & Fred Liers, PhD

Living with Radiation: Protection Starts Today by Dr. Hank Liers


Rejuvenate! PLUS Superfood is High in DNA and RNA with sprouts, chlorella & more by Mike Adams

Product Review: Rejuvenate Berries & Herbs superfood is rich in RNA, plant proteins by Mike Adams

Superfood for Cellular Survival by Dr. Mark Sircus


Interview with Dr. Hank Liers, Part 1: Nutritional supplements and cellular energy

Interview with Dr. Hank Liers Part 2: High-RNA superfoods

Interview with Dr. Hank Liers Part 3: Chemical sensitivities and chlorella detoxification

Interview with Dr. Hank Liers Part 4: Reversing mass chemical contamination

Interview with Dr. Hank Liers Part 5: Superior nutrition for pet health









Fred Liers PhD dietary RNA nucleic acids DNA Dr. Hank Liers, PhD RNA dietary nucleic acidsLast month Fred wrote a blog article focusing on the scientific contributions of pioneer RNA researcher Dr. Benjamin S. Frank titled “Dietary Nucleic Acids – Dr. Benjamin S. Frank, Part 1.”

This month we present intriguing, practical ideas regarding the remarkable effects of dietary nucleic acids (RNA, DNA) – provided by high-RNA foods and superfoods like Rejuvenate!™ – for improved athletic performance and physiological function of the body.

Dietary nucleic acids significantly boost many human physiological functions. The effects and benefits of dietary RNA have been studied and documented for more than 40 years. Yet, for a variety of reasons, these effects and benefits have not been widely understood, utilized, or applied by sports medicine (and medicine more generally) and athletes, nutritionists, or the general public.

HPDI’s research into the beneficial physiological effects of dietary RNA led us to study the therapeutic benefits of chlorella. This ultimately led to Hank’s formulating Rejuvenate!™ superfoods in order to harness the nutritional benefits of dietary nucleic acids for health and healing.

All Three Rejuvenates RNA nucleic acids

Rejuvenate!™ superfoods are ideal for athletes because they provide high levels of dietary RNA known to improve strength, endurance, tissue oxygenation & recovery.

Many of the benefits of dietary RNA in terms of increasing health and therapeutically for healing also apply for purposes of improving athletic performance. That is, not only do individuals suffering from various health conditions typically benefit greatly from dietary RNA, but also healthy individuals who desire to boost their performance (e.g., in athletic endeavors) gain significant benefits.

The reason athletes can gain significant benefits from nucleic acids is because the same physiological processes required for rapid healing (e.g., ATP production, increased cellular energy, greater cellular oxygenation) are also critical for optimal performance in sports.


It’s a fact that dietary nucleic acids like RNA and DNA supports optimal physiological function in the body. This includes improved athletic performance.

Rejuvenate!™ superfoods provide therapeutically high levels of dietary RNA, which translate into powerful beneficial effects for sports performance. During the past nine years , we at Health Products Distributors, Inc. (HPDI) have developed Rejuvenate!™ superfoods primarily based on research conducted by nucleic acid pioneer Dr. Benjamin  S. Frank during the 1960s and 1970s.

Dr. Frank treated and conducted research on thousands of patients and animals using nucleic acids (consisting of RNA (ribonucleic acid) and DNA (deoxyribonucleic acid)). He discovered that dietary nucleic acids offer unique benefits that increase cellular oxygenation, endurance, functional strength, and physical performance.

RNA dietary nucleic acids rejuvenate superfoods gymnast athletic performance


Dr. Frank’s animal experiments and his experience with human subjects showed many beneficial effects, indicating that dietary nucleic acids (especially RNA) are ideal nutrients for enhancing athletic performance.

Dr. Frank reports include the following beneficial effects:


Dr. Frank’s subjects also reported many positive effects, including:


In addition to dietary RNA and DNA, Dr. Frank found that optimal results were achieved when his patients took a multivitamin and/or a B-complex supplement, minerals, proteins, and essential fatty acids. Rejuvenate!™ superfoods provide these additional nutrients along with therapeutic levels of RNA and DNA.

RNA dietary nucleic acids crew athletic performance rejuvenate superfoods


Among his findings pertaining to improved physical performance, Dr. Frank reports these specific results:

1) Dr. Frank had seven healthy individuals climb flights of stairs both before and after RNA therapy. Whereas fatigue began by rapidly climbing 3 sets of stairs before RNA therapy, after 10 full doses (over a period of 1–2 weeks) of his RNA formula the same group was able to rapidly climb 6–10 flights of stairs before fatiguing.

2) Four males, aged 34–40, who were in very good condition were able to increase their ability to lift weights over their heads by 10–20 pounds after taking his RNA formula for a short time (about 2–3 weeks).

3) Mice were placed in sealed jars to determine whether RNA would affect the length of their survival. Dr. Frank found that RNA-fed experimental animals survived 48 percent longer than those on the control diet. In another experiment, he placed control and RNA-fed rats in a water tank to evaluate their swimming endurance. The RNA-fed rats averaged 15.6 minutes before exhaustion versus 11.3 minutes for the control group.

Amazingly, Dr. Frank discovered that anti-anoxic effect and all the other effects of RNA were long lasting. He found that these effects persisted for weeks after cessation of nucleic acid therapy. Dr. Frank’s experiments support the application of high-RNA therapy for enhancing sports performance in athletes.

Rejuvenate!™ superfoods are designed to provide the high levels of RNA required by athletes to optimize their performance. All major benefits provided by therapeutic levels of RNA serve to increase functional capacity and improve results in sports.

RNA dietary nucleic acids rejuvenate superfoods javelin thrower female


In his books (e.g., Dr. Frank’s No-Aging Diet and Nucleic Acid Nutrition & Therapy), Dr. Frank addresses how dietary RNA dramatically increases cellular energy. RNA boosts energy levels in the body by significantly increasing production of the “high-energy” molecule ATP (adenosine triphosphate). Humans, and especially athletes, require energy from ATP for many purposes, including physical exertion, endurance, recovery, cellular repair, metabolism, muscle growth, etc.


In Nucleic Acid Nutrition and Therapy (1977), Dr. Frank notably asserts that nucleic acids (RNA/DNA) are “essential nutrients of human beings” as distinct from non-essential, accessory nutrients. He considered nucleic acids and nucleotides an essential dietary category, i.e., as being nutrients just as essential for humans as vitamins, minerals, proteins, carbohydrates, and lipids.

Dr. Frank acknowledged the body’s capacity to synthesize some nucleic acids, yet cited the marked improvements in degenerative conditions as the clearest evidence for nucleic acids as essential nutrients. In particular, he noted the health effects resulting from even relatively small (as little as 75 mg) intakes of nucleic acids (e.g., energizing effects, anti-anoxia/oxygen sparing effects, rejuvenation, greater vitality, etc.).

Dr. Frank found he could not obtain such improvements in his subjects by increasing only the intake of vitamins, minerals, proteins, or other essential nutrients. He declares: “Nucleic acids are an essential nutrient in our daily diets, and…optimal health and reduced aging are clearly related to their intake, more than to any other nutrient. Nucleic acids in our diets are of paramount importance for the repairing of molecular and gross tissue degeneration, and for combating the process of aging by simple, effective and essentially non-toxic, natural means.”


Following Dr. Frank’s research studies, Dr. Bernard Jensen helped thousands of his patients recover their health using nucleic acid therapy. In particular, Dr. Jensen dramatically raised awareness of the healing powers of nucleic acids through his publications, including Chlorella: Gem of the Orient (1987). Due to his efforts, chlorella, a high-RNA (5–15%) fresh water algae, is now readily available to consumers and is an ingredient in many superfoods.

In his book Chlorella: Jewel of the Far East (1992), Dr. Jensen simply states: “When we have a sufficient intake of foods rich in DNA and RNA to protect our own cellular nucleic acids, the cell wall continues to function efficiently, keeping the cell clean and well nourished….when our RNA and DNA are in good repair and able to function most efficiently, our bodies are able to use nutrients more effectively, get rid of toxins and avoid disease….cells are able to repair themselves, and the energy level and vitality of the whole body is raised.”

While chlorella is a concentrated source of dietary nucleic acids, we at HPDI believe it’s preferable to consume nucleic acids from a variety of sources. This is because various high-RNA foods and superfoods have unique nucleic acid profiles. Balance is key. In addition, there are other nutrients (e.g., d-ribose and certain B vitamins) that optimize the body’s uptake and utilization of dietary nucleic acids. These are just a few reasons HPDI developed the Rejuvenate!™ line of superfoods.


While Dr. Frank’s sources of RNA were primarily fish, there are now a variety of vegetarian sources of RNA/DNA available, including the fresh water algae chlorella and spirulina, nutritional yeast, chlorella growth factor (CGF), and yeast extracts of RNA/DNA. Rejuvenate!™ superfoods incorporate these sources to provide a minimum of 340 mg of RNA per serving.

Rejuvenate! Plus (500g) RNA nucleic acids

Rejuvenate!™ PLUS is a lighter shade of green than original Rejuvenate!™. It is a “sweet green” formula with RNA, multivitamin & high levels of protein.


Dr. Frank recommends consuming additional nutrients needed by the body for nucleic acids to be optimally effective. These nutrients include proteins, vitamins, minerals, and essential fatty acids. Rejuvenate!™ superfoods include these nutrients. HPDI’s extensive experience formulating high-quality supplements makes it possible to produce powerful synergistic superfoods that combine pure RNA sources with these additional ingredients. For example, HPDI adds rice, hemp, and vegetable sprouts proteins; rice bran solubles; flax and chia seeds; D-ribose; kelp and dulse; coenzyme vitamins; powerful antioxidants (including resveratrol) and phytonutrients; plant-based enzymes; freeze-dried fruits and vegetables; adaptogenic herbs; prebiotics; and functional taste enhancers.

We suggest athletes take Rejuvenate!™ superfoods before, during, and/or after workouts and events. These superfoods are easily consumed, readily digested, and rapidly provide the power of RNA and other superfoods when you need them most.


One serving of Rejuvenate!™ (original) superfood provides about 340 mg of dietary nucleic acids. Serving sizes vary somewhat with Rejuvenate!™ original providing the most per unit weight and more servings per container. Rejuvenate!™ PLUS and Berries & Herbs provide similar levels of dietary RNA with somewhat larger serving sizes, yet these include higher levels of protein, built-in coenzyme vitamin complexes, and other nutrients like herbs.

Rejuvenate! Berries & Herbs

Rejuvenate!™ Berries & Herbs contains no greens, but includes RNA, cell-protective herbs, antioxidants, multivitamin & plant proteins.

Rejuvenate!™ Berries & Herbs actually provides the most dietary RNA per serving at 390 mg. This despite the fact that it’s the only Rejuvenate!™ superfood that does not contain any greens (i.e., chlorella or spirulina).

Results have been gained with as little as one serving per day, i.e., just 340 milligrams of dietary RNA. Dr. Frank notes that an upper limit for most individuals is about 1,500 mg daily. That is, benefits level out beyond this point for most people. However, it has been suggested that for athletes and individuals engaging in extremely demanding activities (e.g., Olympic-level training or extreme sports) benefits can be gained at levels up to 3,000 mg of RNA daily.


For best results, HPDI recommends that individuals take four types of foundational supplements, including Rejuvenate!™ superfoods. Foundational supplements include 1) High-Potency Multivitamin (like Multi Two), 2) Antioxidant / Vitamin C formula (like Ultimate Protector™ or PRO-C™), 3) Essential Fats (like Omega Plus), and 4) Rejuvenate!™ superfoods.

All four types of foundational supplements are important for health. HPDI formulates foundational formulas to work together synergistically for optimal results. Athletes and regular folks can experience greater results (and greater health) when using all four types simultaneously. Note: Both Rejuvenate!™ PLUS and Rejuvenate!™ Berries & Herbs provide a built-in multivitamin, so this may reduce the need for a high-potency multivitamin.


“I personally have taken Rejuvenate superfoods for eight years. Some of the benefits I have noticed during this period include increased lean muscle mass, greater strength, improved lung capacity, better endurance, smoother skin, and greater overall well-being. More recently, I gained the benefit of rapid healing. At the end of May 2011, I had knee surgery to reconstruct an anterior cruciate ligament (ACL) which was severely damaged in an auto accident back in November 2010. This injury put a sudden end to my workouts, yoga, and even normal walking. Six weeks before surgery, I boosted my intake of original Rejuvenate! to eight to ten scoops per day knowing it would help speed healing.

My healing and recovery was remarkably rapid. I experienced little pain after surgery and the incision point is now a faded scar that is scarcely noticeable. I also quickly regained strength and flexibility. My doctor was extremely pleased with my progress, and my physical therapist was pleased that I was months ahead of standard benchmarks for recovery time.

I then started a walk–run program. It felt great running for the first time in months. I certainly engaged in many healthful practices to hasten my healing. However, I feel taking larger amounts of Rejuvenate! original is the single most important factor providing powerful, effective nutrition to support rapid recovery from my injury. It also provided the nutrition that supported my return to active life and participation in sports. I am now fully recovered from my injuries and surgery. I still take Rejuvenate!™ daily.”

rejuvenate.original greens RNA dietary nucleic acids

Rejuvenate! (original greens) provides 340 mg of dietary RNA per 12g scoop (about two tablespoons).


Many other individuals report benefits similar to those Fred gained. Here are some comments we’ve received from individuals who gained benefits relating the athletic performance and improved energy levels after taking Rejuvenate! superfoods. These persons range from a professional cyclist to competitive runners, a surfer, and ordinary people who notice improved physical performance.

“As a professional athlete I am very conscious of my nutrition and the food and supplements I put in my body. When I recently tried the Rejuvenate! PLUS and Rejuvenate! Berries & Herbs products from HPDI and incorporated them into my diet (even for just a few days), I immediately noticed a difference in my recovery, next workout muscle fatigue, and overall daily body stamina. The quality of these products is incomparable and through my tight regimen of physical activity and nutrition I am able to see the effects and difference a supplement can make.”

Irena Ossola
Professional Cyclist & Personal Coach
Team Cloud Racing, Tucson, Arizona
Wenzel Coaching

“During moderate to high physical activity, like mountain biking to work or fast day-hiking, I have noticed that Rejuvenate! Berries & Herbs and Rejuvenate! Plus have the apparent ability to improve my LT (lactate threshold), the stable level at which my body is using lactic acid at the same rate it is producing it. In simpler terms this means that I can exercise longer and stronger, increasing the level at which I first begin to feel fatigue or “burn” in my muscles. It’s a benefit that’s hard to beat.”
– Jim B., San Manuel, Arizona

“I have already mentioned in the past how great all other Rejuvenate products have been working on me, but the Berries and Herbs has opened up a new dimension for me. I feel amazing every day, brimming with energy, being very productive and capable of doing a whole lot many more things than ever before.”
– Oleg P., Australia

“I am a marathon runner and I just started on Rejuvenate! Plus. Compared to the carbohydrate loading I was doing previously, I noticed after taking a single scoop of Rejuvenate! Plus that my energy level didn’t peak and fall, but remained high throughout my workouts.”
– Charles C., Oracle, Arizona

“We’ve got our entire family on Rejuvenate!. My husband’s mother (who has just been diagnosed with angina) was here staying with us about 2 weeks ago and we gave her a tub to take home with her. When she was here she found it difficult to get a breath walking up slight inclines, etc. Well! You should have seen the email we got from her yesterday…her breathing is remarkable, she is full of energy, and her actual words were “I want to run a marathon! I wouldn’t be without this product for a day…”

Thank you so much!”
– Karen W., UK

“Rejuvenate! Plus gives me a sense of inner wellness and power. I am 56 now but feel much younger than that. If I miss a few days I seem to slow down. After a couple days back on it, I am full of FIRE again.”
– Alan A., Monument Valley, Colorado

“I used to fight daily to not fall asleep in the afternoon, but now I have so much more energy…I go running in the afternoon even after surfing in the morning and waking up at 4:45 am!”
– Ariana H., Santa Cruz, California

“I have been using Rejuvenate! PLUS as I get within a couple weeks of 10k and half marathon races. It provides me with a kick and liveliness that just continues to help improve my personal best results. I gain that extra push to shave off time and perform at my peak. It also makes recovery time much shorter and a lot more effective.”
– Chris Pings, Cañon City, Colorado

RNA nucleic acids athletic performance beach volleyball rejuvenate superfood

Dietary RNA supports physiological function for optimal athletic performance.



Dr. Frank’s No-Aging Diet: Eat and Grow Younger. Dial Press, 1976.

Nucleic Acid Nutrition and Therapy. Rainstone Publishing, 1977

Nucleic Acid and Anti Oxidant Therapy of Aging and Degeneration. Royal Health Books, 1977.

Nucleic Acid Therapy in Aging and Degenerative Disease–A Metabolic Approach with DNA, RNA, and Related Metabolites. Psychological Library, 1968.


Ribonucleic Acid Part One: A Highly Effective Anti-Aging Supplement by Ward Dean

Ribonucleic Acid Part Two: Review of Potential Anti-Aging Effects by Ward Dean

Ribonucleic Acid Part Three: Potential Therapeutic Uses: Review of Clinical Experience with RNA by Ward Dean

Revisiting a Scientist’s Work: New Studies Reinforce Older Ones…RNA Therapy May Slow Down Aging by Jeffrey Laign



High-RNA Rejuvenate! Superfood by Hank Liers, PhD

9 Things to Know about Rejuvenate!™ Superfoods by Fred Liers, PhD


Super-Tasty Morning Nutritional Drinks by Dr. Hank Liers & Fred Liers, PhD

Living with Radiation: Protection Starts Today by Dr. Hank Liers


Rejuvenate! PLUS Superfood is High in DNA and RNA with sprouts, chlorella & more by Mike Adams

Product Review: Rejuvenate Berries & Herbs superfood is rich in RNA, plant proteins by Mike Adams

Superfood for Cellular Survival by Dr. Mark Sircus


Interview with Dr. Hank Liers, Part 1: Nutritional supplements and cellular energy

Interview with Dr. Hank Liers Part 2: High-RNA superfoods

Interview with Dr. Hank Liers Part 3: Chemical sensitivities and chlorella detoxification

Interview with Dr. Hank Liers Part 4: Reversing mass chemical contamination

Interview with Dr. Hank Liers Part 5: Superior nutrition for pet health










Dr. Hank Liers, PhD natural nrf2 activators healing potential

When I first learned about Nrf2 activators in early 2012, I became quite enthusiastic about new knowledge that natural substances called polyphenolic compounds had the ability to activate this transcription factor. Once released in the cell Nrf2 can migrate to the nucleus and cause the body to endogenously produce high levels of key protective/antioxidant enzymes.

I soon published several blog articles on this subject including a June 2012 article entitled New Directions For Preventing Free-Radical Damage and a July 2012 article entitled Natural Phytochemical Nrf2 Activators for Chemoprevention.

Also, I actively began the development of a new product called Ultimate Protector™ that contains many concentrates and extracts from fruits and vegetables. This product functions as 1) an excellent source of many Nrf2 activators contained in 29 different fruits and vegetables, 2) a source of powerful antioxidants exhibiting an ORAC5.0 value of 486,000 units in six small capsules, and 3) a source of non-GMO Vitamin C.

NRF2 Activators in Ultimate Protector

Ultimate Protector™ Nrf2 Activator Formula

In October 2012, I published a blog article titled Ultimate Protector™ Brunswick Labs ORAC5.0™ Test Results summarizing the laboratory test results that showed Ultimate Protector’s extremely high antioxidant values for the top five free-radical types found in the body.

It is interesting to note that over 16 years ago I formulated a wonderful antioxidant formula called PRO-C™. PRO-C™ contains Buffered Vitamin C (in the form of powdered calcium, magnesium, and zinc ascorbates), high-potency Grape Extract (from grape pulp, skins, and seeds), Green Tea Extract, reduced Glutathione, N-Acetyl-L-Cysteine (NAC), R-Lipoic Acid, coenzyme forms of Vitamin B2 and Vitamin B6, and Selenium.

PRO-C™ has been one of the most effective products at supporting health I have ever formulated. Our current knowledge shows that PRO-C™ contains four effective Nrf2 activators, selenium needed for glutathione peroxidase functioning, Vitamin B2 and Vitamin B6 that support the effectiveness of glutathione, and antioxidants including Vitamin C and glutathione. I recently wrote a blog article titled PRO-C™ SUPER ANTIOXIDANT FORMULA that provides details concerning this formula.

My current personal list of supplements that I (and my wife) take every day includes both Ultimate Protector™ and PRO-C™. We feel gifted to have these products available to us!!

In this article, I will provide greater insight into the natural sources of Nrf2 activators and how they perform in the body.


Activation of Nrf2 results in the induction of many cytoprotective proteins. We have seen articles that claim over 200 different enzymes can be produced in the body by Nrf2 activators, but have also seen reference that over 4,000 enzymes may be produced!  Examples of some of the key enzymes are shown below:

  • NAD(P)H quinone oxidoreductase 1 – a prototypical Nrf2 target gene that catalyzes the reduction and detoxification of highly reactive quinones that can cause redox cycling and oxidative stress.
  • Superoxide dismutases (SOD) – enzymes that catalyze the dismutation of superoxide (O2) into oxygen and hydrogen peroxide. Thus, they are an important antioxidant defense in nearly all cells exposed to oxygen where superoxide is one of the main reactive oxygen species. SOD is known to provide powerful antinflammatory activity.
  • Glutamate-cysteine ligase which is the rate-limiting step in the synthesis of glutathione (GSH), a very powerful endogenous antioxidant. Glutamate-cysteine ligaseis a characteristic Nrf2 target gene, which establish Nrf2 as a regulator of glutathione, one of the most important antioxidants in the body.
  • Heme oxygenase-1 (HO-1) is an enzyme that catalyzes the breakdown of heme into the antioxidant biliverdin, the anti-inflammatory agent carbon monoxide, and iron. HO-1 is a Nrf2 target gene that has been shown to protect from a variety of pathologies, including sepsis, hypertension, atherosclerosis, acute lung injury, kidney injury, and pain.
  • The glutathione S-transferase (GST) family includes cytosolic, mitochondrial, and microsomal enzymes that catalyze the conjugation of GSH with endogenous and xenobiotic electrophiles. After detoxification by GSH conjugation catalyzed by GSTs, the body can eliminate potentially harmful and toxic compounds. GSTs are induced by Nrf2 activation and represent an important route of detoxification.
  • The UDP-glucuronosyltransferas (UGT) family catalyze the conjugation of a glucuronic acid moiety to a variety of endogenous and exogenous substances, making them more water soluble and readily excreted. Important substrates for glucuronidation include bilirubin, and acetaminophen. Nrf2 has been shown to induce UGT1A1 and UGT1A6.
  • Multidrug resistance-associated proteins  (Mrps) are important membrane transporters that efflux various compounds from various organs and into bile or plasma, with subsequent excretion in the feces or urine, respectively. Mrps have been shown to be upregulated by Nrf2 and alteration in their expression can dramatically alter the pharmacokinetics and toxicity of compounds.


The March 2011 Epub Biochemical Basis for Functional Ingredient Design from Fruits reports: “Functional food ingredients (nutraceuticals) in fruits range from small molecular components, such as the secondary plant products, to macromolecular entities, e.g., pectin and cellulose, that provide several health benefits.  In fruits, the most visible functional ingredients are the color components anthocyanins and carotenoids.

“In addition, several other secondary plant products, including terpenes, show health beneficial activities.  A common feature of several functional ingredients is their antioxidant function. For example, reactive oxygen species (ROS) can be oxidized and stabilized by flavonoid components, and the flavonoid radical can undergo electron rearrangement stabilizing the flavonoid radical.  Compounds that possess an orthodihydroxy or quinone structure can interact with cellular proteins in the Keap1/Nrf2/ARE pathway to activate the transcription of antioxidant enzymes.

“Carotenoids and flavonoids can also exert their action by modulating the signal transduction and gene expression within the cell. Recent results suggest that these activities are primarily responsible for the health benefits associated with the consumption of fruits and vegetables.”

One of the interesting aspects of the extensive research that has been conducted is the fact that many of the polyphenols that have been shown to activate Nrf2 have been used in natural healing formulas for many years. For example, an article in a November 2010 production titled Nutraceutical antioxidants as novel neuroprotective agent expands on the classes of “antioxidant” compounds that are neuroprotective and operate either via direct antioxidant action or via the keap1-Nrf2 pathway:

“A variety of antioxidant compounds derived from natural products (nutraceuticals) have demonstrated neuroprotective activity in either in vitro or in vivo models of neuronal cell death or neurodegeneration, respectively. These natural antioxidants fall into several distinct groups based on their chemical structures: (1) flavonoid polyphenols like epigallocatechin 3-gallate (EGCG) from green tea and quercetin from apples; (2) non-flavonoid polyphenols such as curcumin from tumeric and resveratrol from grapes; (3) phenolic acids or phenolic diterpenes such as rosmarinic acid or carnosic acid, respectively, both from rosemary; and (4) organosulfur compounds including the isothiocyanate, L-sulforaphane, from broccoli and the thiosulfonate allicin, from garlic.

“All of these compounds are generally considered to be antioxidants.  They may be classified this way either because they directly scavenge free radicals or they indirectly increase endogenous cellular antioxidant defenses, for example, via activation of the nuclear factor erythroid-derived 2-related factor 2 (Nrf2) transcription factor pathway. Alternative mechanisms of action have also been suggested for the neuroprotective effects of these compounds such as modulation of signal transduction cascades or effects on gene expression. Here, we review the literature pertaining to these various classes of nutraceutical antioxidants and discuss their potential therapeutic value in neurodegenerative diseases.”

Ultimate Protector NRF2 Activator ORAC


One of the ways dietary flavonoids work to confer their multiple health effects is via the keap1-Nrf2 pathway.  That is substances which are both themselves antioxidants and activators of the keap1-Nrf2 pathway produce significant results through keap1-Nrf2 and activating the body’s own antioxidant and defensive systems.

Flavonoids are a large family of polyphenolic compounds synthesized by plants. Many of the common dietary flavonoids are shown in Table 1 below along with their common food sources.

Table 1: Common Dietary Flavonoids

Flavonoid Subclass Dietary Flavonoids Some Common Food Sources
Anthocyanidins  Cyanidin, Delphinidin, Malvidin, Pelargonidin, Peonidin, Petunidin Red, blue, and purple berries; red and purple grapes; red wine
Flavonols  Monomers (Catechins) Catechin, Epicatechin, Epigallocatechin, Epicatechin gallate, Epigallocatecin gallate Dimers and Polymers: Theaflavins, Thearubigins, Proanthocyanidins Catechins: Teas (particularly green and white), chocolate, grapes, berries, apples Theaflavins, Thearubigins: Teas (particularly black and oolong) Proanthocyanidins: Chocolate, apples, berries, red grapes, red wine.
Flavanones Hesperetin, Naringenin, Eriodictyol Citrus fruits and juices, e.g., oranges, grapefruits, lemons.
Flavonols Quercetin, Kaempferol, Myricetin, Isorhamnetin Widely distributed: yellow onions, scallions, kale, broccoli, apples, berries, teas.
Flavones Apigenin, Luteolin Parsley, thyme, celery, hot peppers.
Isoflavones Daidzein, Genistein, Glycitein Soybeans, soy foods, legumes.

In addition to flavonoids many other plant based substances appear to produce health benefits through hormetic effects mediated by Nrf2.  The December 2011 publication Nutritional antioxidants and adaptive cell responses: an update reports: “Many plant antioxidants, intaken through the daily diet or plant-derived dietary supplements, have been shown able to prevent free radical-related diseases by counteracting cell oxidative stress. However, it is now considered that the in vivo beneficial effects of these phytochemicals are unlikely to be explained just by their antioxidant capability.

“Several plant antioxidants exhibit hormetic properties, by acting as ‘low-dose stressors’ that may prepare cells to resist more severe stress. In fact, low doses of these phytochemicals activate cell signaling pathways (being the most prominent examples the modulation of the Nrf2/Keap1 pathway, the NF-κB pathway and the Sirtuin-FOXO pathway) but high doses are cytotoxic.

“Herein we review the adaptive responses induced by the most known plant hormetic antioxidants, which are sulforaphane, resveratrol, curcumin, flavonoids, green tea catechins and diallylsulphides [in garlic], as well as the molecular mechanisms involved in such responses. Furthermore, this review outlines that the hormetic properties of these bioactive plant antioxidants might be successfully employed for realizing health-promoting dietary interventions especially in the field of neurodegenerative diseases and cancer.”

Ultimate Protector Nrf2 activator


1) An interesting fact is that Nrf2 is ubiquitously expressed with the highest concentrations (in descending order) in the kidney, muscle, lung, heart, liver, and brain. 

2) Another important fact is that the well-known nutrition supplement lipoic acid is a potent activator of Nrf2 and thus increases Gluthatione levels, which may explain its protective effect against diabetic co-morbidities. Additionally, the nutritional supplements tocotrienols (active forms of Vitamin E) and N-Acetyl-L-Cysteine (NAC) are also effective Nrf2 activators!

3) We have observed that the natural plant substances with the highest ORAC5.0 values appear to be among the most effective Nrf2 activators. For example, see the table below. In particular, note that Curcumin (98%), Grape Seed Extract, Green Tea Extract, and Reservatrol which are commonly used for their excellent Nrf2 activator effects are the most powerful in-vitro antioxidants . Please note that Ultimate Protector is over 50% more powerful as an antioxidant than the best single plant ingredient.


Ingredient Peroxyl Radical Hydroxyl Radical Peroxy-nitrite Radical Super-
oxide Radical
Singlet O2 Radical Total ORAC5.0
Curcumin 98% 5,750 8,920 906 597 66,290 82,500
Bilberry 25% 7,000 25,000 1,000 16,000 5,000 54,000
Cocoa 10,000 28,000 1,000 11,000 2,000 52,000
Grape Seed Extract 17,000 47,000 1,000 25,000 4,000 94,000
Green Tea Extract 11,000 41,000 2,000 56,000 3,000 113,000
Coffee Berry Extract 5,000 29,000 1,000 1,000 2,000 38,000
Mangosteen 4,000 8,000 1,000 18,000 4,000 35,000
Pine Bark 7,000 23,000 1,000 17,000 2,000 50,000
Resveratrol 12,000 50,000 1,000 8,000 22,000 93,000
ULTIMATE PROTECTOR 6,300 5,900 2,500 106,000 52,000 173,000
Results are expressed in micro mole TE/g
4) Here is a list of the ingredients in ULTIMATE PROTECTOR™:  USP-grade non-GMO Buffered Vitamin C, AnthoComplete™ (high-ORAC powder from Wild Blueberry, Wild Bilberry, Acai, Black Currant Extract, Sweet Cherry, Raspberry, Elderberry, Blackberry, Aronia, Black Soybean Hull Extract, and Blue Corn), CoffeeBerry®Forte (high-ORAC powder from Coffee Berry), Curcumin (standardized extract with 95% curcuminoids), Trans-Resveratrol (98% from Giant Knotweed), VitaBerry®Plus (high-ORAC powder: from freeze-dried Grape Seed, Wild Blueberry, Wild Bilberry, Cranberry, Tart Cherry, Prune, Raspberry Seed, Strawberry, Trans-Resveratrol, and Quercetin), VitaVeggie® (high-ORAC powder from Broccoli, Broccoli Sprouts, Tomato, Kale, Carrot, Brussels Sprouts, Onion and Spinach), and Bioperine® (a patented black pepper extract that enhances absorption of all ingredients).


Below are two abstracts that discuss how modulation of the Nrf2/ARE pathway by food polyphenols can provide neuroprotection through the activation of the heme-oxygenase enzyme.

Modulation of Nrf2/ARE pathway by food polyphenols: a nutritional neuroprotective strategy for cognitive and neurodegenerative disorders. (Oct. 2011)


In recent years, there has been a growing interest, supported by a large number of experimental and epidemiological studies, for the beneficial effects of some phenolic substances, contained in commonly used spices and herbs, in preventing various age-related pathologic conditions, ranging from cancer to neurodegenerative diseases. Although the exact mechanisms by which polyphenols promote these effects remain to be elucidated, several reports have shown their ability to stimulate a general xenobiotic response in the target cells, activating multiple defense genes.

Data from our and other laboratories have previously demonstrated that curcumin, the yellow pigment of curry, strongly induces heme-oxygenase-1 (HO-1) expression and activity in different brain cells via the activation of heterodimers of NF-E2-related factors 2 (Nrf2)/antioxidant responsive element (ARE) pathway. Many studies clearly demonstrate that activation of Nrf2 target genes, and particularly HO-1, in astrocytes and neurons is strongly protective against inflammation, oxidative damage, and cell death. In the central nervous system, the HO system has been reported to be very active, and its modulation seems to play a crucial role in the pathogenesis of neurodegenerative disorders.

Recent and unpublished data from our group revealed that low concentrations of epigallocatechin-3-gallate, the major green tea catechin, induces HO-1 by ARE/Nrf2 pathway in hippocampal neurons, and by this induction, it is able to protect neurons against different models of oxidative damages. Furthermore, we have demonstrated that other phenolics, such as caffeic acid phenethyl ester and ethyl ferulate, are also able to protect neurons via HO-1 induction. These studies identify a novel class of compounds that could be used for therapeutic purposes as preventive agents against cognitive decline.

The major green tea polyphenol, (-)-epigallocatechin-3-gallate, induces heme oxygenase in rat neurons and acts as an effective neuroprotective agent against oxidative stress. (Aug. 2009)


Oxidative stress induced by hyperglycemia is a key factor in the pathogenesis of diabetic complications, such as neuropathy. Recently, green tea catechins have received much attention, as they can facilitate a number of antioxidative mechanisms and improve glycemic control. The aim of this study was to investigate the cytoprotective effects of (-)-epigallocatechin-3-gallate (EGCG) against oxidative stress damage in a cell line of rat neurons. The role of heme oxygenase 1 (HO-1) induction by EGCG and the transcriptional mechanisms involved were also evaluated.

Immortalized rat neurons (H 19-7) were exposed to various concentrations of EGCG (10-200 microM). After treatments (6 or 24 hours), cells were harvested for the determination of heme oxygenase activity, mRNA levels, and protein expression. Nuclear levels of Nrf2, a transcriptional factor involved in HO-1 activation, were also measured. Neurons were pretreated for 12 hours with EGCG 50 microM or EGCG 50 microM + zinc protoporphyrin IX 10 microM and then exposed for 2 hours to 50 mmicro/mL glucose-oxidase before cell viability was determined.

In cultured neurons, elevated expression of HO-1 mRNA and protein were detected after 6 hours of incubation with 25-100 microM EGCG, and its induction relates with the activation of Nrf2. Interestingly, pre-incubation (12 hours) with EGCG 50 microM resulted in an enhanced cellular resistance to glucose oxidase-mediated oxidative damage; this cytoprotective effect was considerably attenuated by zinc protoporphyrin IX, an inhibitor of heme oxygenase activity.

In this study, we demonstrated that EGCG, the major green tea catechin, induced HO-1 expression in cultured neurons, possibly by activation of the transcription factor Nrf2, and by this mechanism was able to protect against oxidative stress-induced cell death.


The following review article abstract shows how natural products containing Nrf2 activator/antioxidant ingredients might be used to support health and anti-aging.

Nrf2/ARE Signaling Pathway: Key Mediator in Oxidative Stress and Potential Therapeutic Target in ALS (July 2012)


Abstract: Nrf2 (nuclear erythroid 2-related factor 2) is a basic region leucine-zipper transcription factor which binds to the antioxidant response element (ARE) and thereby regulates the expression of a large battery of genes involved in the cellular antioxidant and anti-inflammatory defence as well as mitochondrial protection. As oxidative stress, inflammation and mitochondrial dysfunctions have been identified as important pathomechanisms in amyotrophic lateral sclerosis (ALS), this signaling cascade has gained interest both with respect to ALS pathogenesis and therapy. Nrf2 and Keap1 expressions are reduced in motor neurons in postmortem ALS tissue.

Nrf2-activating compounds have shown therapeutic efficacy in the ALS mouse model and other neurodegenerative disease models. Alterations in Nrf2 and Keap1 expression and dysregulation of the Nrf2/ARE signalling program could contribute to the chronic motor neuron degeneration in ALS and other neurodegenerative diseases. Therefore, Nrf2 emerges as a key neuroprotective molecule in neurodegenerative diseases.

Our recent studies strongly support that the Nrf2/ARE signalling pathway is an important mediator of neuroprotection and therefore represents a promising target for development of novel therapies against ALS, Parkinson’s disease (PD), Huntington’s disease (HD), and Alzheimer’s disease (AD). Simultaneous blockage of disease-specific broad toxic signaling cascades in motor neurons and glia may ultimately lead to more efficient neuroprotection in ALS. Stimulation of defense mechanisms that modulate neuroprotective genes which affect both neuronal and glial functions is a novel therapeutic approach and holds great promise. A key molecule to affect a variety of defense mechanisms is the transcription factor Nrf2 which activates the Nrf2/ARE signaling program. Nrf2 acts as master regulator of the cellular antioxidant response by stimulation of over 250 phase II genes that should be referred to as “prolife genes” since they save cells from death.

Nrf2 activation can at once regulate the expression of multiple cytoprotective enzymes that are capable of simultaneous inhibition of major pathogenic pathways described in ALS such as oxidative stress, neuroinflammation, and mitochondrial dysfunction. Decreased Nrf2 expression was found in motor neurons in ALS postmortem brain and spinal cord. We have established the proof-of-concept that the Nrf2/ARE program is a viable target with excellent therapeutic potential for ALS. While there are still multiple gaps of knowledge on the path from Nrf2 dissociation to nuclear localization and its action as transcription factor, activation of the Nrf2 signaling cascade represents a novel and unique attempt to find a cure for ALS and other neurodegenerative diseases by fortifying the intrinsic defense mechanisms of neurons.


In this article I have shown how foods such as fruits, vegetables, herbs, and their extracts can stimulate extremely powerful protective enzymes in the body that work to keep us healthy. I strongly suggest that our readers eat an organic diet that emphasizes these foods and highly recommend the use of nutritional supplements such as Ultimate Protector™ and PRO-C™ that can further support the activation of the Nrf2 pathways in the body!