2

QUICKSILVER LIPOSOMAL FORMULAS – NEW PRODUCTS!

Fred Liers PhD quicksilver liposomal formulasOne of the most significant developments for nutrient uptake and assimilation is the advent of liposomal delivery systems. Once in the range of 300–5,000 nanometers, the latest liposomes are now just 20–100 nanometers (nm)!

The significance of these small liposomes—tiny bilayer lipid structures—is that there is a major increase in the amount of nutrient delivery to cells. That is, small liposomes show significantly greater efficiency at intracellular delivery of encapsulated compounds.

Liposomal delivery systems have evolved rapidly and now offer major advantages over nutritional supplements delivered by standard means—like capsules, tablets, powders, and liquids (e.g., tinctures).

Liposomal delivery systems first utilized multi-lamellar vesicles (MLV) ranging ins size from 300–5,000 nanometers. Later, “large” unilamellar vesicles (LUV) (100–300 nanometers) were developed. Products containing LUVs are more effectively assimilated than MLVs.

As noted, lipsomal technologies have shrunk liposome sizes to 20–100 nanometers (nm), the category size for small unilamellar vesicles (SUV). This means the body can far more easily assimilate nutrients delivered liposomally when the particle sizes are up to 10 times smaller than already effective liposome sizes.

Small liposomes (SUV) have a long circulation half-life and better cellular accumulation. Small lipid particles have the fastest uptake kinetics and can participate in paracellular (between cells) transport. The nutritional liposome industry is rapidly moving toward the use of small liposomes.

Key Point: Small liposomes (SUV) are significantly more efficient at intracellular delivery of encapsulated compounds. In a recent study with carefully sized liposomes, cellular uptake increased nine-fold as liposome size was decreased from 236 nm to 97 nm and was 34 fold higher at 64 nm.

Nutrients that can be delivered liposomally range from vitamin C and glutathione to many types of adaptogenic and medicinal herbs.

Benefits of Liposomal Delivery

  • Rapid update, assimilation, and movement into cells
  • Oral intake bypasses digestive system—nutrients go directly into body
  • High levels of nutrients assimilated
  • Reduced dosages and less “wasted” product
  • Nutrients penetrate smallest compartments in the body
  • Nutrients circulate widely
  • Precise intra-oral delivery
  • Simple manual pump from glass bottle
  • Easy water dispersability when desired
  • Good tasting!

Liposomal delivery systems are the future of nutritional supplements given all the advantages they confer. HPDI recognizes the value of liposomal products, and now offers the best formulas available—from Quicksilver Scientific, Inc.—to our customers.

QUICKSILVER LIPOSOMAL FORMULAS

HPDI offers four liposomal formulas from Quicksilver Scientific, the leader in nanoliposomal delivery systems. Each formula offers unparalleled uptake and assimilation—and good taste!—via inta-oral delivery. These products include:

Quicksilver liposomal formulas

HPDI offers four liposomal formulas from Quicksilver Scientific.

Liposomal Vitamin C with R-Lipoic Acid (mean size 50–100nm): Quicksilver Scientific’s Etheric Delivery™ system for Liposomal Vitamin C (with R-Lipoic Acid) is the most absorbable form of professional-grade Vitamin C. Vitamin C is essential to any detoxification program because it feeds the system that eliminates toxins. It is also very effective in removing lead and other heavy metals from our system and fighting off the free radicals that form in the liver during the first phase of detoxification.

R-Lipoic Acid (as sodium R-Lipoate) has an exceptionally well-documented ability to upregulate the glutathione system via the Nrf2 nuclear transcription pathway. This combination of liposomal vitamin C and R-Lipoate in a nanoliposomal delivery system potently harnesses the potential of Vitamin C to the power of a fully functioning glutathione system.

The absorption of conventional oral Vitamin C diminishes rapidly as the dose increases (e.g., about 19% for 1000 mg oral vitamin C). Nanosphere delivery greatly increases absorption and for some compounds can provide higher intracellular delivery than an IV administration.

Quicksilver Vitamin C

Quicksilver Liposomal Vitamin C with R-Lipoic Acid

Suggested Usage: General use for antioxidant and detoxification function, take eight pumps per day (1,000 mg of Vitamin C and 50 mg of R-Lipoate). For advanced intermittent use, use up to 50 pumps per day (6,250 mg Vitamin C and 312.5 mg R-Lipoate) or more, in divided doses throughout the day. For detoxification protocols, especially with metal toxicities, build dosage gradually, starting from low doses, as they are tolerated. If strong detoxification reactions are observed, back off dosage. Children should start at approximately 1/4 of adult (two pumps per day) dosage and work up. For topical application, one pump can cover the face for a daily treatment, or use several pumps as a mask and leave on for 10–15 minutes; skin can be re-wetted and left for another 10 minutes before rinsing off excess.

Liposomal Glutathione: Quicksilver’s Phospholipid Encapsulation Etheric Delivery system protects glutathione from digestive enzymes that otherwise inhibit absorption of oral glutathione supplementation. In cell cultures, liposomal products have demonstrated over 100 times more efficiency for intracellular delivery than IV-based liposomal glutathione.

Quicksilver’s Liposomal Glutathione comes with a precision pump to accurately deliver 50 mg of reduced glutathione and 68 mg of injectable-grade essential phospholipids (derived from sunflower oil) per pump. The patent-pending process, plus a natural lemon flavoring, allows this product to be taken intra-orally for maximum absorption without the foul sulfur taste typical of liposomal glutathione products. The formula can be taken every 3–4 hours for even delivery throughout the day. One bottle delivers 100, 0.5 ml doses.

Quicksilver Liposomal Glutathione

Quicksilver Liposomal Glutathione with Lemon Mint

Suggested Usage: For general antioxidant and detoxification protection, use eight pumps per day (400 mg glutathione). For advanced protection, use up to 20 per day (1,000 mg glutathione) or more, in divided doses throughout the day. For large doses, take two pumps at a time to allow for maximum oral absorption, and hold at least 30 seconds before swallowing. Children should start at approximately 1/4 of adult (two pumps per day) dosage and work up.

Liposomal Colorado Hemp Oil: This product uses non-THC (<0.3%) cannabidiol (CBD) from all-natural Colorado Hemp Oil. CBD is the non-psychoactive part of the industrial hemp plant. Quicksilver Scientific’s liposomal delivery of Nanoemulsified Colorado Hemp Oil far outpaces tinctures and is faster, stronger and more effective. Cannabidiol interacts with our body’s naturally occurring cannabinoid receptors to aid with pain relief and enhanced feelings of well being. The advanced technology behind this groundbreaking liquid delivery method makes for precise dosing and immediate effect.

Because of the known interaction of CBD with these cannabidiol receptors, much new research has focused on CBD’s receptor-mediated neuro-protective, antiemetic, and analgesic properties, and of its effect on mood and other aspects of mental health.

New research on gene transcription modulation offers an even deeper look into the biochemical mechanisms at work when ingesting CBD. Research in this vein has shown more than 1,000 genes that are differentially upregulated by CBD (a more than ten-fold increase than those affected by THC). In general, the effects increased cell stress responses—including antioxidant-defense and detoxification genes (mainly via EhRE/ARE-Nrf2 induction)—and downregulated many inflammation-mediating genes. These effects combined with CBDs NMDA-receptor-stabilizing effects, show great promise for its use in calming the neuro-inflammatory responses accompanying neurotoxic and chronic illness states.

Quicksilver Nanoemulsified Colorado Hemp Oil

Nanoemulsified Colorado Hemp Oil

Suggested Use: Take 1–4 pumps by mouth, holding for 30 seconds before swallowing. Repeat if needed. Four pumps contain 30 mg of Hemp Extract (aerial parts) and 12 mg of Phytocannabinoid Diols. There are 25 four-pump servings per container. Best taken on an empty stomach 10 minutes before meals. May be stirred into a small amount of water. Once opened, use within 60 days. Store at room temperature and away from light.

Liposomal NanoMojo (adaptogenic blend): Dr. Christopher Shade, PhD of Quicksilver Scientific, collaborated with master herbalist Dan Moriarty of Sun Horse Energy to create NanoMojo, a groundbreaking functional medicine product. By combining Moriarty’s unique adaptogenic formulation with Dr. Shade’s state-of-the-art liposomal encapsulation, they’ve overcome the limitations of poor oral adsorption and made the phytochemicals quickly available at the cellular level. This new innovative blend of adaptogens from around the world is maximized for effectiveness.

Adaptogens are non-toxic phytochemicals that help the body achieve homeostatic balance under adverse conditions that would typically be associated with sympathetic (fight or flight) reactions. They help regulate natural harmony, adrenal balance, and stress accommodation (resistance to stress). In fact, adaptogenic herbs have been used in Ayurvedic medicine for more than 4,000 years and Chinese medicine for nearly 3,000 years to increase energy (chi) and concentration.

Scientific literature reports that adaptogenic herbs play significant roles in decreasing markers of stress-activated protein kinases, cortisol, and nitric oxide. These markers indicate a lowered level of systemic stress and inflammation and decreased symptoms of an over-taxed adrenal system.

NanoMojo contains the following adaptogenic herbs: Açaí, Lyceum (Goji) fruit, Gynostemma (Jiaogulan) (aerial parts), American Ginseng (root), Siberian Ginseng (root), Schisandra (fruit), Licorice (root), Rhodiola (root), Astragalus (root), Reishi (fruiting body), Catuaba (bark), Stinging Nettle (aerial parts), Saw Palmetto (fruit), Guarana (seed), Ashwagandha (root), Tribulus (aerial parts), Epimedium (aerial parts), Yohimbe (bark), and Organic Maple (sap) syrup.

NanoMojo helps your body adapt to the various conditions that cause stress, something most of us experience daily. This liposomal formulation is the culmination of more than eight years of research and development. Not only is it effective, but it also tastes very good.

Quicksilver liposomal NanoMojo adaptogens

NanoMojo Liposomal Adaptogenic Blend

Directions: Take two pumps twice daily, or more. May be mixed into a small amount of water. Best taken on an empty stomach. Once opened, use within 60 days.

CONCLUSION

The advent of small liposomes means significantly greater uptake and assimilation of nutrients than ever before. This means you stand to benefit greatly from advanced intra-orally delivered nanoliposomal formulas like those developed by Quicksilver Scientific, Inc.

 

 

SOURCES & RESOURCES

ARTICLES

Recent Advances in Liposome Technology (HPDI blog)

PRODUCTS

Quicksilver Scientific Liposomal Formulas (HPDI website)

Liposomal Vitamin C with R-Lipoic Acid

Liposomal Glutathione with Lemon Mint

Nanoemulsified Colorado Hemp Oil

NanoMojo Liposomal Adaptogenic Blend

 

0

ULTIMATE PROTECTOR INGREDIENTS – BLACK SOYBEAN HULL EXTRACT

Dr. Hank Liers, PhD biography about us HPDI integratedhealth formulator founder CEO scientist physicist wild bilberry and wild blueberryUltimate Protector™ contains black soybean hull extract, as well components from 29 different fruits, vegetables, and herbs. Each of these ingredients contain substances that may be considered to be polyphenols, antioxidants, and Nrf2 activators. In this article I explore the ingredient black soybean hull extract, which is a component of Anthocomplete™ from Futureceuticals.

ANTHOCOMPLETE™

AnthoComplete™ (N669) is a specially designed blend of anthocyanins derived from wild bilberry and wild blueberry, acai, black currant extract, sweet cherry, raspberry, elderberry, blackberry, aronia, non-GMO black soybean hull extract, and blue corn. Anthocyanins are powerful plant polyphenols associated with a variety of areas of human health, including healthy aging, healthy glucose metabolism, cardiovascular health, and inflammation management.

Carefully designed to maximize the amount of beneficial anthocyanins that can be available in a single source, AnthoComplete is a proprietary formula suitable for a wide-range of applications.

With its diverse blend, AnthoComplete contains a minimum level of 10% anthocyanins, 3,000 ORAC μmole TE/g (typical), and 15% total phenolics (typical).

Owing to the high levels of anthocyanins, an important type of antioxidants, black soybean hull extract has been shown by scientific research to have many benefits in promoting health and preventing diseases. The antioxidant polyphenols in black soybean hull extract (particularly anthocyanins) may help in maintaining cardiovascular health, aging and brain health, urinary tract health and healthy vision.

 

Black Soybeans

Black Soybeans – source of black soybean hull extract

Black soybean hull extract (Glycine max) has been used in a wide variety of foods for many years. Ongoing research is further showing the benefits of black soybean hull extract based largely on the polyphenolic content and its related products.

This product is selected non-GMO black soybean hull extract. It is rich in anthocyanin and anthocyanidins that protect capillaries and promote red blood cell regeneration.

Benefits include:

  • Helps to renew eyesight, reduces eye inflammation, and alleviates visual fatigue
  • Helps reduce dementia
  • Reduces blood fat and blood sugar
  • Reduces oxidized LDL cholesterol levels
  • Reduces blood pressure
  • Accelerates circulation of blood
  • Helps beautify skin
  • Supports weight loss
  • Helps to ameliorate adiposity
  • Significantly supports conditions associated with menopause
  • Supports the reduction of night sweats, dizziness and headaches
  • Reduce muscle recovery time after workout

In addition, the anthocyanins have been shown to positively influence the α-glucosidase phase of starch digestion providing a reduction of sugar release during starch food digestion.

Also, black soybean hull extract is a good source of glycosylated flavonols. Scientific studies at the fundamental cellular level have indicated that these compounds can interact with the bodies own innate Antioxidant Response Elements (ARE), such as the transcription factor Nrf2, and more specifically stimulate expression of the detoxification enzymes such as NAD(P)H:quinone oxidoreductase, glutathione S-transferase, and uridine diphosphate-glucuronosyltransferase isoenzymes.

Scientific Studies on the Antioxidant Effects of
Black Soybean Hull Extract

Below, I provide a few relevant scientific studies on the antioxidant effects and potential health benefits of Black soybean hull extract.

Oral Toxicological Studies of Black Soybean (Glycine max) Hull Extract: Acute Studies in Rats and Mice, and Chronic Studies in Mice.

Abstract

Black soybean (Glycine max) has been used for traditional medicine and food in Asian countries, but safety of its hull has not been studied. We conducted acute and chronic oral toxicity studies. For the acute study, an extract of black soybean hull (BE; 2.5 g/kg body weight) was administered singly by intragastric intubation to Sprague-Dawley rats and C57BL/6 mice. There was no death or significant decrease in body weight in rats and mice, and the oral LD(50) of BE was >2.5 g/kg body weight. In the chronic study, BE was administered at dietary levels of 0% (control), 2.0%, and 5.0% to male and female C57BL/6 mice for 26 weeks. No mortality or toxicologically significant clinical changes were observed through the experimental period. Although body weights, as well as abdominal fat, blood levels of triglyceride and total cholesterol in 5.0% males were significantly lower than that in control and 2.0% groups, these changes were considered not to be adverse. Hematology and histopathological observation revealed no toxicologically significant changes. The no-observed adverse-effect-level of BE was estimated to be 5.0% in the diet (5074.1 mg/kg body weight/day for males and 7617.9 mg/kg body weight/day for females).

Black Soybean Hull Extract, Method for Obtaining,
and Use Thereof:
US PATENT 8206764 B2

Abstract

Methods for preparing black soybean hull extracts and uses thereof. The methods can comprise: (1) extracting crushed black soybean hull with aqueous solution containing enzyme and filtering the extracted liquid; (2) ultrafiltration of the extract liquid with an ultrafiltration membrane; (3) absorbing the ultrafiltration liquid with an absorption resin or an ion exchange resin, and elution with ethanol to obtain purified extract liquid; (4) concentrating the purified extract liquid under vacuum; (5) spray drying the concentrated liquid. The extract can contain: 10-45% of cyanidin, 10-25% of catechin, and 40-80% of OPC, and with a total polyphenol content as high as 70-100%. The extract can be used for preparing drugs or food containing antioxidants, or used for improving metabolic syndrome or eyesight.

Soybean Seed Coats: A Source of Ingredients for Potential Human Health Benefits-A Review of the Literature.

From: https://www.researchgate.net/publication/278026407_Soybean_Seed_Coats_A_Source_of_Ingredients_for_Potential_Human_Health_Benefits-A_Review_of_the_Literature

Abstract

Soybean seed coats are an underutilized byproduct from the commercial crushing of soybeans to make soymeal and soy oil. These seed coats constitute 7 to 10% of the weight of a bushel of soybeans so they provide a substantial opportunity to add value to each bushel. Overall, the United States produces approximately 6 million metric tons of seed coats each year. Biologically active compounds contained in soybean seed coats have been shown to prevent and or reduce macular degeneration, obesity, cancer, and many other debilitating diseases. For example, the seed coats of YJ-100 black soybeans contain more than 20 mg/g of anthocyanins, the highest concentration of anthocyanins of all plants materials including other row crops. The purpose of this paper is to examine the chemical content of soybean seed coats, highlight opportunities to add value and discuss the potential health benefits of these chemicals.

Clinical Study of Ocular Function With Food Product Containing Black Soybean Hull Extract

From: http://www.kuromanin.com/眼科臨床_英文_.pdf

Introduction

As the number of individuals using VDT (visual display terminals) increases, research investigations concerning diagnosis of asthenopia and methods for evaluation have been reported.

However, all aspects of asthenopia are not fully understood, and the problem has been treated as a single syndrome characterized primarily by an ocular nonspecific complaint. Suzumura1) classified the causes of asthenopia into three groups relating to visual organ factors (ocular capability), external environmental factors (visual conditions), and internal environmental factors and psychological factors (endurance) and explained asthenopia as an imbalance of these three elements. Other reports on treatment of asthenopia have also been made, but there is currently no established method of treatment.

Another recent topic is foods with a notable effect of eliminating “ocular fatigue” and restoring vision. These include anthocyanin glycosides, natural pigments derived from a number of plants. The physiological functions of these substances have interested researchers from various countries.

In particular, anthocyanin extract from bilberries has been approved as a pharmaceutical in Italy, France, and New zealand and is used to treat night blindness, capillary fragility, cerebrovascular disorders, and peptic ulcers. In Japan, Kajimoto2) et al. reported that blueberry extract used in asthenopia and psychological strain had an improving effect.

Based on the fact that the physiological activity of the black soybean hull extract in our clinical study (cyanidin- 3-glucoside) includes promotion of rhodopsin resynthesis and capillary strengthening, and that this substance is an anthocyanin glycoside and contains upwards of 90% cyanidin-3-glucoside, reportedly the anthocyanin highest in antioxidant activity, we surmised that cyanidin-3- glucoside would improve visual function and have an antioxidant effect.

We report good results obtained from a clinical investigation using foods containing black soybean.

 

SUMMARY

Black soybean hull extract is an important ingredient full of polyphenols, anthocyanins, antioxidants, and Nrf2 activators that help to make Ultimate Protector such an outstanding nutritional supplement.

ALKALINIZE WITH LEMONADE DIET & PH ADJUST

Fred Liers PhD lemonade pH Adjust alkalinizing formulaSummer is here. That means lemonade! As in the “Lemonade Diet” or “Master Cleanse.” The lemonade diet is famous since Stanley Burroughs wrote his classic, The Master Cleanser. Hollywood has used his lemonade diet for decades—for health and weight loss. In recent years, the lemonade diet has gone mainstream.

While safe, effective weight loss may be its “claim-to-fame,” the lemonade diet is useful as a kidney cleanser promoting the health of the kidneys and bladder system, including the entire urinary tract. The lemonade diet cleanses kidneys best when combined with kidney-specific herbs like Uva ursi, parsley, cornsilk, and juniper berry.

A major reason lemonade is beneficial for health is that it’s highly alkalinizing in the body. Lemonade itself is acidic on the pH scale. Yet, after it is in the body it acts as an alkalinizer! That might seem counterintuitive. But your health—and alkalinity—can count on lemonade to increase your pH levels.

Acid-alkaline balance is critical for health. Your body must maintain a pH of about 7.35–7.45. If you’re too acidic, then your body will find ways (even robbing your bones for minerals) to buffer acidity. Diets high in fruits and vegetables are more alkaline-forming, at least partly due to high potassium levels. High potassium levels drive higher alkalinity.

You can—and should—measure your pH using litmus paper. Once you’ve got a baseline of your pH levels, you can see for yourself how dietary changes—like the lemonade diet—help move your pH toward greater alkalinity and improved acid-alkaline balance.

Given that modern, Western diets high in meats and simple carbohydrates are acid-forming—often in the extreme—it makes sense that lemonade benefits anyone who needs to be more alkaline. Of course, I’m not talking about sugar-laden, or pre-mixed, artificially sweetened, fake lemonade drinks. I mean real lemonade—which is the only kind that works as a “master cleanser.”

I have written about the lemonade diet, as well about kidney & bladder cleansing. I often perform a 3–7 day summer kidney cleanse using kidney herbs—including tinctures and teas—and follow it with a few days of the lemonade diet.

lemonade diet

Make lemonade: squeeze fresh lemons, add maple syrup and cayenne pepper

This summer, I totally reversed order. I started with a 15-day lemonade diet and followed it with a three-day kidney cleanse. You can gain huge alkalinizing (and kidney cleansing) benefits from lemonade alone.

The original recipe for the Lemonade Diet:*

2 Tbsp organic Lemon or Lime Juice
2 Tbsp organic Maple Syrup (dark color/robust taste) (Grade A)
8 ounces fresh water
1/4 tsp organic Cayenne Pepper (optional)

(* from The Complete Master Cleanse)

Modify the recipe to suit your taste. The original recipe can be strong and sweet. However, it provides sufficient calories (from maple syrup) to live on for days, weeks, or longer. Try using lime juice for a different flavor. I often use more water—up to 16 ounces or more—for this amount of ingredients.

Among the nutritional supplements that helps me while lemonade fasting—and especially on the longer fasts—is Rejuvenate! Original Greens superfood. It is highly energizing and nourishing. I recommend using a green superfood like Rejuvenate! Original Greens because it is highly energizing and nutritious, yet light in the body and supports detoxification. You can put it directly into your lemonade or take it separately. I prefer to stir it into my second or third serving of lemonade—so early in the day—but not in my first dose of lemonade.

Not only does Rejuvenate! Original Greens provide powerfully nutrition, including important vitamins and minerals, it also supports detoxification processes as it contains chlorella (40%) and dietary nucleic acids (dietary RNA and DNA). The cell wall of chlorella uniquely has the capacity to grab onto heavy metals, chemical contaminants, and toxins—and sequester them for removal from the body. Dietary nucleic acids are energizing and support detoxification processes.

I have used the “Lemonade Diet” for 20 years—in all seasons—at home and “on the road.” I typically go for one to three weeks. I have successfully completed longer lemonade diets, including several for six weeks and at least one for two months. I may not take Rejuvenate! every day during a lemonade diet, but this superfood provides benefits that help turn a “good” master cleanse in a “great” one.

MY LEMONADE DIET—AND A TWIST

After 15 days of lemonade, I feel lighter, leaner, and totally alkaline. In fact, I am more alkaline after this lemonade diet than ever before. Why? Because I did something different this year—I added a twist to my routine.

Instead of following my usual lemonade diet, I added a new alkalinizing supplement called pH Adjust. It is a pure, white powder that you can add to water or lemonade (or other liquid drinks) providing minerals formulated to boost alkalinity: potassium bicarbonate and glycinate, magnesium carbonate, and sodium bicarbonate.

I sometimes added pH Adjust to my lemonade. Other times I took it by itself in water. I started at one-quarter teaspoon (1/4 tsp) daily, and worked up to one teaspoon (1 tsp) daily over the course of my lemonade diet. Adding pH Adjust to my regimen made a significant difference in my overall alkalinity by increasing my pH levels. And I could feel the difference.

pH ADJUST

pH Adjust is formulated specifically to alkalinize your body. I believe it can be more alkalinizing than lemonade itself. Yet, lemonade and pH Adjust work well together to increase pH levels.

I test my pH levels daily using pH paper. I find that when compared to lemonade alone, adding pH Adjust boosts my alkalinity noticeably. I easily maintained an alkalinity between 7.4 and 8.0 for my entire 15-day lemonade diet. That is, I could more easily maintain a higher alkalinity than with lemonade alone.

Note: If I were to continue the lemonade diet longer than two or three weeks, I would recommend reducing or stopping use of pH Adjust. That’s because while you most likely want maintain a relatively higher pH level than you had before you started the lemonade diet, it is best not to maintain a pH of 8.0 for extended periods as you run the risk of too high pH. That won’t be a problem for most people, but testing your pH levels using litmus paper is important. Then you will know your pH levels—and can more readily balance your pH.

After you complete the lemonade diet and return to consuming solid foods, then it is advisable to use pH Adjust to maintain a balanced, but relatively alkaline pH of about 7.45—which is actually an optimal pH for health.

Keeping you alkaline is what pH Adjust is formulated to do…and it fulfills that promise—easily! Now it’s up to you to test your pH, get started on a more alkaline-forming diet, and feel the difference for yourself. Once you’re in the proper alkaline range, you won’t want to go back. And you’ll be better for it!

SOURCES & RESOURCES

BOOKS & SCIENTIFIC ARTICLES

The Master Cleanser by Stanley Burroughs

The Complete Master Cleanse by Tom Woloshyn

Acid & Alkaline by Herman Aihara

Acid-alkaline balance: role in chronic disease and detoxification
(Altern Ther Health Med, 13(4):62-5)

Potassium Intake of the US Population (PDF)
(NHANES Food Surveys Research Group, USDA)

BLOG ARTICLES

Got Potassium?

Alkalinize Rapidly Using pH Adjust

pH Adjust Alkalinizing Formula – New Product!

Racing and Recovery with pH Adjust Alkalinizing Formula

PRODUCTS

pH Adjust
(alkalinizing formula)

pH paper
(Hydrion litmus paper)

Rejuvenate! (Original Greens) superfood

Rejuvenate! product comparison chart

RACING AND RECOVERY WITH pH ADJUST ALKALINIZING FORMULA

Irena Ossola bike racing recovery pH Adjust alkalinizing formulaEditor’s note: HPDI’s sponsored pro cyclist Irena Ossola is a frequent contributor to our blog. Today she writes about her experience with adjusting and monitoring her pH levels using pH Adjust and pH test strips. ~

I have used HPDI’s pH Adjust alkalinizing formula for about two months, and my experience has been quite interesting. I can see how my body reacts on a chemical level to different stresses—such as racing, travel, training, rest, and different foods I eat. I consistently use pH paper to test my pH first thing when I wake up in order to have a more controlled test.

My primary finding is that after a race my body is quite acidic (pH of 6.3). While in contrast after a day of rest and/or dinner consisting of lots of vegetables and spinach my body is quite alkaline (pH of 7.5 to 8).

TESTING MY pH LEVELS FOR ALKALINITY

While in France and racing very hard, I noticed that taking pH Adjust every morning helped my body feel more balanced and avoid spikes of energy or tiredness. I could rest and sleep more deeply, and train with both greater quality and frequency.

Irena Ossola ph test pH Adjust

Wearing my HPDI gear. Products like pH Adjust and Rejuvenate! superfoods keep in me in top condition.

After a month in France of hard racing and training, I began experiencing leg cramping due to the fatigue and travel. I remained consistent in my testing and taking pH Adjust through this difficult period. Initially, my tests were very acidic when the cramps began. Then as my diet consisted of just soup and salad (to hydrate and ease the burden on my digestion/kidneys) the pH test strips showed my pH to be more alkaline.

Also, I read that bicarbonate could help with cramping as it acts as a buffer in the body. So I continued to take the pH Adjust consistently and even increased my doses by adding an evening dose as well, if my afternoon/evening pH test showed my body was acidic (below pH 7).

DIET AND pH ADJUST KEEP ME ALKALINE

During the period of cramping I know pH Adjust helped to reestablish an alkaline environment in my body. This is important in order to heal from the cramping which creates a lot of lactic acid and fatigue in my muscles. I noticed the symptoms were reduced. During the cramping stage, I usually have cramping even when walking, but this time it was limited primarily to the bike. I recovered faster and felt better sooner, which I think is a result of the pH Adjust and the correct diet.

test pH paper

Testing pH levels with litmus paper guides my diet and use of pH Adjust.

Even after travel and during my return to harder training I will continue to take pH Adjust as part of my normal routine. There is nothing else available or on the market that acts so specifically to balance the pH within the body. This is so important as we introduce and put many stresses on our body that take it out of balance. Whether it is environmental or nutritional, these stresses can lead to further problems. So simply taking pH Adjust every morning can help protect against these variables. I feel the difference when I am consistent in taking it, and my body is under constant stresses due to my work as a professional cyclist.

pH Adjust

pH Adjust helps me maintain optimal pH levels—there’s nothing else like it.

JUICE CLEANSE AND RECOVERY

Last month I returned from Europe where I was suffering from some leg cramping, so I decided to do a body cleanup. I was still taking pH Adjust in the morning and my normal supplements, but I also wanted to do a 3–5 day juice cleanse. This helped the recovery as it cleans out my kidneys and gives my digestion a rest. Whenever I return from travel or racing I try to do a juice cleanse to reboot my system.

Irena Ossola ph test ph adjust

Me and my bike!

The three day juice cleanse ended up being a great flush, and my legs were recovering very well after all the travel, racing, cramping, and stress.

I did notice some feelings of fogginess in my head during the cleanse. But I was told that this is not uncommon to feel as it could be either from the reduced amount of protein entering the body, or because the toxins are being cleaned out of the system, so the mind is also readjusting to this as well.

I have noticed that the more juice cleanses I do, the faster and easier my body adjusts to the fluid diet. I don’t feel hunger, but just craving for the juice and energy. As long as I have enough juice made and on hand, I don’t feel worried about my ability to nourish my body. Without intense training I really enjoy the cleanse and don’t feel the need or cravings for sugar or certain foods. It simplifies life, and allows me to focus on important things like training and my work as a pro cyclist.

Pro Tip: When going through lots of stress on the body like exercise, illness, surgery, polluted environments, etc., increase the amount of Rejuvenate! superfoods in your diet and eat sardines. Both of these nutritional components will help speed up recovery time, and battle any incoming hazards and risk factors to your body.

irena ossola rejuvenate superfoods

Pro Tip: Rejuvenate! superfoods support recovery after training and racing.

SOURCES & RESOURCES

OssolaSport.com
(Official website)

Irena Ossola page
(HPDI Reseller site)

BLOG ARTICLES

Power Juice & Super Smoothie of Pro Cyclist Irena Ossola

Racing on Rejuvenate! Superfoods

Juice Journey of Cyclist Irena Ossola

All About the Balance – Mind, Body, and Nutrition

Resolving 2014 – Cyclist Irena Ossola on Training

Pro Cyclist Irena Ossola’s Rejuvenate! Smoothie

Get Results with Rejuvenate! Superfoods

Introducing Professional Racing Cyclist, Irena Ossola

PRODUCTS

pH Adjust Alkalining Formula

pH paper
(litmus test paper)

Rejuvenate! superfoods
(comparison chart)

HOMOCYSTEINE GENETICS – COENZYME B VITAMINS

Dr. Hank Liers, PhD homocysteine coenzyme B vitaminsWe previously published an article titled FOLATE INGREDIENTS – FOLINIC ACID & 5-MTHF in which we discuss how coenzyme folate vitamins are far superior to the synthetic folic acid form. In today’s article, I take a more in-depth look at how homocysteine is formed from methionine, how genetics affects the metabolic pathways, and how B vitamins are used in metabolic pathways.

One way to look at the metabolic pathways of methionine (an essential amino acid) is that it provides a way for the body to convert this sulfur containing amino acid either to cysteine and its key by-products glutathione, taurine, and sulfates or allows remethylation back to methionine to occur using either the Folate Cycle or the Trimethyl glycine (betaine) pathways.

Figure 1 shows these metabolic pathways including the vitamins required at each step including vitamin B6 (as P-5-P), methylcobalamin, and 5-methyltetrahydrofolate (5-MTHF). In addition, it shows the key enzymes produced by the body at each step. These enzymes include CBS (cystathione beta synthase), BHMT (betaine homocysteine methyltransferase), MS (methionine synthase), and MTHFR (methylene tetrahydrofolate reductase).

homocysteine metabolism diagram

Figure 1. Metabolic Pathways in Methionine and Homocysteine Metabolism

HEALTH ISSUES ASSOCIATED WITH HIGH HOMOCYSTEINE LEVELS

It is highly important that the various metabolic pathways function correctly to keep homocysteine at healthy levels (6–8 µmol/L). Unfortunately, high levels of homocysteine in the body (10–20 µmol/L) are a factor in a wide range of health issues, including:

  • Greater risk for heart problems, including coronary artery disease, heart attacks, stroke, high blood pressure, congestive heart failure, and abnormal cholesterol levels. This is due to increased inflammation, sometimes due to blood clotting spontaneously, and because of blockages of the major arteries.
  • Mental abnormalities such as depression, anxiety, bipolar disorder, and other mental problems are more common among people with high homocysteine
  • Migraines and headaches in a significant percentage of the population
  • In those who suffer from high homocysteine due to having nutritional deficiencies anemia, aches and pains, hearing loss, age-related macular degeneration (ARMD), slowed development, and birth defects might also be possible
  • Greater risk for dementia, Alzheimer’s disease, brain atrophy, and other cognitive problems
  • In children, skeletal and developmental abnormalities including having a curved spine or protruding chest and rib cage. Some patients appear very tall and thin, and some might also have very long, thin “spider-like” toes and fingers.
  • Behavioral problems, including ADHD, autism and other learning disabilities

ROLE OF GENETICS IN HOMOCYSTEINE METABOLISM

Ten or more years ago, questions of how genetics enters into homocysteine metabolism were unlikely to be asked. However, in recent years DNA testing has advanced and is now available to everyone (for example, see my article about Bodysync’s genetic test, DISCOVERING NUTRITIONAL NEEDS THROUGH ADVANCED GENETIC TESTING.

You may have heard a great deal about MTHFR (methylene tetrahydrofolate reductase). This gene is involved in folate metabolism and has a central role in methylation processes like repair of and building new DNA in dividing cells.

In the remethylation pathway for conversion of homocysteine to methionine, MTHFR plays a key role in converting folate into 5-MTHF which is needed along with B12 as methylcobalamin in order for the conversion to take place. Genetic variations in MTHFR have been studied in depth. Of the many variations studies the most significant ones appear to be variations of C677C such as C677T (referred to as heterozygous) or T677T (referred to as homozygous). The heterozygous variant appears in about 30–50% of the population and causes somewhat less efficiency in the conversion of folic acid to 5-MTHF. However, the homozygous variation occurs in about 10% of the population and can have serious effects due to converting little homocysteine back to methionine.

Another variation in MTHFR is called A1298A. These variations are A1298C and C1298C and will have similar effects to the C677C variations. It was interesting to me when I recently analyzed my Bodysync genetic test results showing I carry the variation A1298C (heterozygous), which indicates I may not be effectively converting homocysteine back to methionine.

Additionally, my Bodysync genetic test results also indicate that I have heterozygous variations in the CBS enzyme shown in Figure 1, as well as heterozygous variations in MTR and MTRR enzymes, which are involved with B12 levels in the remethylation pathway. These results indicate that I need to take higher levels of methylcobalamin and 5-MTHF.

IMPORTANCE OF COENZYME FORMS AND PROPER AMOUNTS OF B VITAMINS

Many of the B vitamins on the market today unfortunately are in synthetic form. The body can only use the natural coenzyme forms effectively. For example, the body needs vitamin B6 in the form of P-5-P (pyridoxal-5-phosphate), folate in the form of L-5-MTHF, and B12 in the form of methylcobalamin for proper metabolism of methionine. In some cases the body can use the synthetic forms of pyridoxine HCl, folic acid, and cyanocobalamin but pays a cost (e.g., in time and energy) by having to convert synthetic forms to coenzyme forms.

Add to the prevalence of synthetic B vitamins, the fact that genetic deficiencies are more common than previously assumed, and it becomes clear that the coenzyme forms of B vitamins in the proper amounts are extremely important.

Fortunately, I have always believed it best to include as many coenzyme forms as possible in the nutritional supplements I formulate (over the past 27 years). For example, all HPDI multivitamins include coenzymes of B1, B2, B6, B12, and folate (as 5-MTHF and folinic acid). This is uncommon in most multivitamin formulas on the market. For this reason our supplements are ideally suited to the prevention or resolution of most genetic problems regarding homocysteine.

In addition, I have always chosen to include higher amounts than most multivitamins on the market. We also make available 5-MTHF one milligram (1 mg) capsules and methylcobalamin five milligram (5 mg) sublingual tablets. When genetic variations are in play as discussed above, then providing relatively higher amounts of coenzyme B vitamins that support important requirements in the body seems necessary.

Interestingly, several other nutrients are involved in the pathways involving methionine and homocysteine. These include zinc, magnesium, and Vitamin B2. Our multivitamin formulas and magnesium formulas, especially Myo-Mag with its coenzyme B1, B2, and B6, are recommended to support these nutrient needs. Finally, it has been found that N-Acetyl-L-Cysteine (NAC) can significantly lower homocysteine (by up to 50%), most likely because its gives the body an excellent source of cysteine without have to use methionine.

SUMMARY

In this article, I have shown the value of the use of genetic testing and high-quality coenzyme B vitamins in resolving health issues associated with high values of homocysteine in the body.

 

SOURCES & RESOURCES

DISCOVERING NUTRITIONAL NEEDS THROUGH ADVANCED GENETIC TESTING.

FOLATE INGREDIENTS – FOLINIC ACID & 5-MTHF

The Homocysteine Revolution by Kilmer S. McCully, MD

Role of hyperhomocysteinemia in endothelial dysfunction and atherothrombotic disease
(Cell Death and Differentiation 11, S56–S64)

PRODUCTS

5-MTHF
(coenzyme folate)

Methylcobalamin
(vitamin B12)

B-Complex-50

HPDI Multivitamins