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EFFECTIVE PAIN RELIEF STRATEGIES WITH WARRIOR MIST

Fred Liers PhD warrior mist effective pain reliefI am excited this month to talk about Warrior Mist, which is an all-natural skin, muscle, and joint support formula. Warrior Mist is a topical formula that is my go-to-product for effective pain relief.

Warrior Mist is highly effective for pain. Indeed, my father Dr. Hank Liers formulated it for rapid pain relief, naturally. Many health care professionals find it useful for their clients.

Being applied topically on skin, Warrior Mist acts quickly at the pain source to stop it. Topical application is an advantage when it comes to rapid relief.

Warrior Mist topical effective pain relief

Warrior Mist comes in a pump-spray glass bottle.

NATURAL INGREDIENTS FOR EFFECTIVE PAIN RELIEF

Beyond its effectiveness against pain, what I like about Warrior Mist is that it contains all-natural ingredients. What does that mean? Most of its ingredients are herbal like peppermint oil, lavender oil, and organic coconut and olive oils.

Warrior Mist contains: DMSO (99.999% pure), peppermint oil (the source of menthol in the product), organic olive oil, distilled water, MSM, magnesium chloride, lemon oil, lavender oil, and organic coconut oil.

Warrior Mist contains no harsh chemicals or synthetic preservatives (like parabens, dimethicone, or phenoxyethanol). What else would you expect from a formulator like Dr. Hank Liers or a company like Health Products Distributors?

For anyone who cares about NOT putting toxic chemicals on their skin, Warrior Mist is a high-purity formula worthy of consideration. It is a pure, simple, and effective formula.

Warrior Mist comes in a spray bottle made of glass, not plastic. Shake it, then spray it. Gently massage the area of application to assist absorption. That’s all there is to it.

WARRIOR MIST APPLICATIONS FOR PAIN

Warrior Mist is effective for many applications, including pain relief for joints (wrists, elbows, knees, ankles), bruises and scratches, as well as insect bites and skin irritations. I occasionally I spray it directly into my mouth for throat relief, especially in winter or during allergy season (although technically it is not for internal use).

AIKIDO

I practice aikido, which can stress joints, especially wrists. Most aikido techniques involve grips that can become throws. There are also strikes, counterstrikes, blocks, falls, rolls, wrist breaks (escapes), and other movements.

Aikido is safe when practiced carefully. Yet, many techniques can lead to bumps, bruises, strains, sprains, and soreness. Warrior Mist helps me (and others) a lot. In fact, I donated a bottle of Warrior Mist to the dojo, so it’s there for anyone who needs it.

I am not sure what I would do for routine aches and pains without Warrior Mist. Sometimes just having relief after an aikido workout makes a big difference in my day.

My eight-year-old son also practices aikido in the same dojo. I feel confident using Warrior Mist on him because it is a safe, natural product that works.

I also practice yoga. Yoga rarely results in the types of minor injuries I experience from aikido. Yet, for times when I overstretch a muscle or overdo a pose, I reach for Warrior Mist for rapid, effective pain relief.

HIKING

I enjoy hiking. We live on the edge of a desert wilderness north of Tucson, Arizona. There are cactus, thick brush, thorny bushes, and biting insects like ants and scorpions. Many hikes involve at least a few thorns, scrapes, or mild soreness. Warrior Mist helps with these.

I have used Warrior Mist for bee and scorpion stings, ant bites, scrapes, cuts, small puncture wounds (e.g., from cactus spines), as well as skin irritations of various kinds.

In fact, there are few types of pain I have found Warrior Mist doesn’t mitigate. I use it for shoulder pain, neck pain, and lower back pain when it occurs. I notice the sooner I get Warrior Mist on the affected area, the faster I experience relief.

I don’t personally suffer from headaches, but friends who do tell me Warrior Mist helps them a lot. One of the ingredients is magnesium chloride, which is known to help ease headaches, including migraine headaches. Gently rub Warrior Mist around temples, forehead, or base of the neck.

Pain relief is not always immediate when using Warrior Mist. Yet, I know from experience how much it helps. The ingredients it contains support healing, too. Be patient, give it time, and allow it to work. That is exactly what I do sometimes.

AROUND HOUSE, YARD, AND GARDEN

Warrior Mist is ideal to keep in the house for everyday bumps and bruises like stubbed toes, bruised shins, or skinned knees. We find it useful after yardwork or gardening. You can spray it directly on an area, or else spray it into your hand first (after shaking the bottle), and then rub it into an affected area.

I know of two people who use Warrior Mist for pain in the tailbone (coccyx), the final segment of the vertebral column. Tailbone pain for them was originally caused by falling. One person fell from a horse and the other off a skateboard. While these injuries are structural, Warrior Mist provides significant relief. The reduction in pain helps daily function and facilitates sleep.

WARRIOR MIST FOR PETS

Warrior Mist is safe for use with pets. In fact, it was originally formulated for pets with the help of a veterinarian. You can feel confident using Warrior Mist on pets, large and small. It is ideal for use on dogs, cats, horses, and farm animals. Many veterinarians use Warrior Mist in their clinics for effective pain relief.

If you are a veterinarian, consider using Warrior Mist for your pet patients.

PROFESSIONAL USES

My wife Stefanie is a practicing acupuncturist. She uses and recommends Warrior Mist for her clients.

She frequently uses Warrior Mist in her practice for knee pain, shoulder pain, and back pain. What she often does is mix about five sprays (pumps) of Warrior Mist with about ten sprays of Magnesium Oil along with a dime-sized amount of carrier oil (like organic jojoba oil or coconut oil) in her palm.

She mixes the liquids in her palm (for amounts up to one tablespoon), but it can be mixed and stored a small container. For greater amounts, the ratios remain the same – about 2:1 Magnesium Oil to Warrior Mist – with correspondingly higher amounts of carrier oil. This is an excellent mixture because it combines the benefits of Warrior Mist and Magnesium Oil.

There is a slight chemical reaction that occurs when Warrior Mist mixes with Magnesium Oil. It is actually a warming effect. Stefanie likes it because the mixture is then applied warm, which relaxes muscles and opens pores for better absorption. No “warm up” is necessary and clients seem to appreciate the mixture’s warmth.

The mixture (of Warrior Mist, Magnesium Oil, and carrier oil) may be applied directly on affected areas with high rates of success. Clients themselves can obtain Warrior Mist and Magnesium Oil to make this mixture at home. Using a carrier oil is helpful, but not required because Warrior Mist contains organic coconut and olive oils.

Warrior Mist Magnesium Oil effective pain relief

Warrior Mist works well mixed with Ancient Minerals magnesium oil.

Stefanie also finds Warrior Mist useful for clients suffering from headaches. In addition, she will apply straight Warrior Mist to the throat, lymph nodes, or upper chest area for clients dealing with respiratory issues. Indeed, she applies it to these areas on herself when she feels she may be fighting or coming down with something.

Use Warrior Mist on clean, dry, lotion-free skin. The DMSO in the formula acts as a solvent carrying substances on skin into the body. This allows natural ingredients in the formula to penetrate into painful areas. Wash hands and the application area (or wipe with a damp cloth) before treatment. Avoid using carrier oils with toxic ingredients (like synthetic preservatives) that could be pulled into the body.

Stefanie tells her clients not to put anything on their skin that they would not eat. That is, use only natural oils and products containing ingredients that are natural and organic. A useful resource to determine what products are most natural is the Skin Deep Database on the Environmental Working Group website (www.ewg.org).

If you are a health care professional who deals with clients requiring pain relief, please contact HPDI to request a sample bottle of Warrior Mist. See how well this effective pain relief formula works for your clients.

Warrior Mist effective pain relief

Wash hands, shake bottle, then spray on clean, dry skin. Massage area to assist absorption.

WARRIOR MIST FOR ATHLETES AND SPORTS

One group of people who love Warrior Mist is athletes, especially runners, triathletes, and other endurance athletes. Warrior Mist is useful for nearly all sports, including contact sports.

HPDI’s sponsored athlete, pro cyclist Irena Ossola, uses Warrior Mist regularly, especially during races and high-intensity training. She incorporates it into the sports massage she receives with reportedly good effects. She also states that it helps her with recovery.

Irena occasionally crashes her bicycle. This remains a hazard in her sport, she says. However, Warrior Mist has done much to help her joints, road rash and other abrasions, sore muscles, and to speed her recovery.

For purposes of athletes, the magnesium chloride in Warrior Mist can help support muscle health and recovery, and provide effective pain relief.

WARRIOR MIST SUMMARY

Dr. Hank Liers designed Warrior Mist as a natural formula containing ingredients known for providing effective pain relief. Given its wide applicability, topical application, natural ingredients, and proven history of use, Warrior Mist is ideal for personal use by consumers and in clinical settings for clients who require effective pain relief.

Warrior Mist is one of the most natural, effective pain relief products available to heath care professionals and consumers alike.

Warrior Mist comes in a 30 ml (1 oz) spray bottle which provides hundreds of applications. A single bottle typically lasts about two months.

Directions: Shake bottle before applying. Wash hands before and after use. Apply in a thin layer to a clean, dry, and lotion-free area needing support. Shave thick hair that may prevent absorption by the skin. Gently massage the area of application to assist absorption. Re-apply as needed 3–4 times daily. (Contains DMSO, a known solvent.)

BEYOND WARRIOR MIST: WARRIOR SLEEP & WARRIOR ENERGY

Warrior Mist is one of three Warrior Health products offered by Health Products Distributors. Dr. Hank Liers formulated these Warrior products, all of which are topicals requiring ultra-low doses (ULD) by design: Warrior Mist, Warrior Sleep, and Warrior Energy.

Warrior Mist Sleep Roll-On Energy effective pain relief

Warrior Mist, Warrior Sleep, and Warrior Roll-On Energy are topical formulas.

Warrior Sleep (9 ml) is an effective, natural sleep and relaxation formula having no drug-like side effects (compared to conventional sleep aids). Like Warrior Mist, you apply Warrior Sleep directly to skin (transdermal application) for rapid absorption. Warrior Sleep incorporates four natural ingredients for sleep: lavender oil, roman chamomile, magnesium, and melatonin. It uses DMSO and natural oils to carry these rest promoters into the body. Warrior Sleep contains: DMSO (99.999% pure), olive oil, distilled water, MSM, magnesium oil, lavender oil, lecithin, roman chamomile oil, coconut oil, and melatonin.

Warrior Sleep

Warrior Sleep is an effective topical relaxation and sleep formula.

Warrior Roll-On Energy (9 ml) is a unique topical roll-on energy product. It is formulated to provide five hours of mental and physical enhancement. One bottle will last 30 days when used twice daily. Warrior Roll-On Energy contains: DMSO (99.999% pure), organic aloe vera gel (inner fillet), distilled water, organic extra virgin olive oil, peppermint oil, magnesium chloride with trace ocean minerals, MSM, organic coconut oil, caffeine (80% from green tea), soy lecithin (high phosphatide and 98% oil free), glutathione (reduced), Vitamin B6 (from pyridoxal-5’-phosphate), Vitamin B12 (as methylcobalamin), and Folinic Acid (from calcium folinate).

Warrior_Roll-On_Energy Warrior Sleep

Warrior Sleep and Warrior Roll-On Energy contain built-in roll-on applicators.

I use all three Warrior products depending on daily needs. Warrior Sleep is an effective sleep aid, but is also effective for relaxation or applied before bedtime to prepare for sleep. I apply to the neck base, upper throat, and temples. We have noticed it nourishes and smooths facial skin. This is due to its synergistic blend of ingredients, including melatonin, MSM, and organic carriers oils.

Warrior Roll-On Energy is uniquely energizing. It differs dramatically from most energy products, or coffee, tea, or chocolate. The formula utilizes ultra-low dose (ULD) technology to carry energizing ingredients (including caffeine from green tea) rapidly into the body. Yet, unlike caffeinated drinks, users typically experience no let down or rapid drop in energy after using it. Warrior Roll-On Energy provides non-jarring, sustained energy during the day (up to six hours).

Health Care Professionals: Please contact HPDI (1-800-228-4265) to request sample(s) of Warrior Mist, Warrior Sleep, Warrior Roll-On Energy, or other products in which you are interested.

RESOURCES

HPDI BLOG ARTICLES

Warrior Mist: Creating an Effective Pain Relief Formula

Super Remedies for Stings and Bites

PRODUCTS

Warrior Mist

Warrior Sleep

Warrior Roll-On Energy

Warrior Products

Magnesium Oil

CONTACT US:

You can reach HPDI by calling 1-800-228-4265, email support(at)IntegratedHealth.com, or visit the retail website: IntegratedHealth.com

Health care professionals and resellers can apply for wholesale account, which includes access to the HPDI reseller website: HealthProductsDistributors.com. Support(at)HealthProductsDistributors.com.

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REJUVENATE! BERRIES & HERBS – INGREDIENTS FOR OPTIMAL NUTRITION

Fred Liers PhD rejuvenate! berries & herbs superfoodI write a lot about superfood ingredients, and especially those in HPDI’s Rejuvenate! superfoods. One superfood I write about less often is Rejuvenate! Berries & Herbs.

This may relate to the fact that Rejuvenate! Original and Rejuvenate! PLUS provide plenty of greens like chlorella and spirulina. Greens make these superfoods popular, and it is easy educating health care professionals and consumers alike on their benefits.

Rejuvenate! Berries & Herbs is different. It provides ultra-high ORAC value (14,200+) per serving. It also provides more dietary nucleic acids (390 mg) per serving than other Rejuvenate! superfoods. It tastes so good it may the HPDI’s best-tasting superfood. Even Health Ranger Mike Adams loves it, and stocks it in his online store.

Rejuvenate! Berries & Herbs superfood

Rejuvenate! Berries & Herbs is one of three HPDI superfoods providing dietary nucleic acids.

REJUVENATE! BERRIES & HERBS IS DIFFERENT: IT LACKS GREENS

But it lacks greens. And greens are what almost everyone wants. As noted, Rejuvenate! Original and PLUS formulas provide high levels of greens like chlorella and spirulina. Berries & Herbs provides none.

For some people, no greens is just great. We developed Berries & Herbs because we want to offer one superfood with high levels of dietary nucleic acids that does NOT contain greens.

Formulating a high-RNA superfood without greens is an admirable goal. Most of the dietary nucleic acids in Rejuvenate! superfoods (and dietary RNA is what makes HPDI superfoods unique) come from greens. For example, chlorella contains amazingly high levels of nucleic acids, more than any other ingredient.

THE VERSATILE, NON-GREEN SUPERFOOD WITH NUCLEIC ACIDS

Rejuvenate! Berries & Herbs was created as superfood lacking greens. It suits its purpose because: 1) certain individuals cannot stomach greens like chlorella; 2) many people enjoy greens, but also desire variety; 3) many prefer a fruity, berry-flavored superfood for reasons of taste–and Berries & Herbs tastes delicious.

While the lack of greens could be perceived as a liability, it is one of the greatest benefits of Rejuvenate! Berries & Herbs.

rejuvenate! berries & herbs superfood greens continuum

Rejuvenate! Berries & Herbs is the HPDI superfood without greens.

In this article, I want to recap the benefits of Berries & Herbs and present some new information on ingredients, characteristics, and qualities of this unique, non-green superfood.

GREENS ARE GREAT, BUT SO ARE “BERRIES & HERBS”

First, I haven’t written an article about Berries & Herbs since February 2014 when I published “Be Healthy with Rejuvenate! Berries & Herbs.” That was an in-depth piece. And the information is still 100% true: I favor greens, as in greens provided by Rejuvenate! Original (greens) and Rejuvenate! PLUS (sweet greens).

One major difference: while I consume plenty of greens those green Rejuvenate! superfoods, there is now more room in my diet for non-green superfoods. That means Berries & Herbs.

I already take 5–10 servings per day of Rejuvenate! Original. That may sound like a lot, but I reduce my food intake to accommodate higher levels of superfoods. I feel satisfied with reduced food intake when consuming higher levels of superfoods.

As a result, my dietary nucleic acid intake is quite high. High levels of dietary nucleic acids are part of what make Rejuvenate! superfoods unique. High-purity and nutrient density are other major benefits.

I probably do not require more dietary nucleic acids (unlike athletes like pro cyclist Irena Ossola whose training and performance benefit from higher levels of dietary RNA). I already get sufficient RNA.

However, there are many reasons I consume Rejuvenate! Berries & Herbs:

 Berries & Herbs can be more filling than Rejuvenate! Original. Therefore it makes a nutritious breakfast drink, or after breakfast power booster.

• Contains a full-spectrum multivitamin. It doesn’t replace my daily multivitamin (Hank & Brian’s Mighty Multi-Vite!), but it does give me an extra boost of vitamins/minerals in liquid form (smoothie, blender drink, or plain in almond milk, juice, or water).

• Tastes amazingly good. That means it makes a delicious and healthy “refresher”  or “snack” between meals. It also makes a great after dinner “dessert” drink.

• Makes yummy shakes of whatever consistency you like. You can use less liquid (or more Berries & Herbs) for a thicker shake. Add a drop or two of stevia if you desire a sweeter taste.

• Tasty replacement for drinks like hot cocoa, tea, or coffee.

• Blends well with milks, yogurt/kefir, nut milks, and herbal teas.

• Great addition to foods, including fruit, berries, granola, and grains.

• Nutritious when used as an ingredient in homemade bars (see bar recipes).

• Delicious in plain water and without added sweeteners.

• Kids love Berries & Herbs. It can be added to drinks and foods as a healthy booster. Since my son loves Berries & Herbs, I use it in his drinks and foods.

These are just a few of the advantages of Berries & Herbs that I know from personal experience, and from talking to many people who use it regularly.

rejuvenate! berries & herbs superfood

MORE THAN MEETS THE EYE: EIGHT BENEFITS OF BERRIES & HERBS

There’s a lot more to Rejuvenate! Berries and Herbs that you might guess. I identified eight key benefits of Berries & Herbs in my previous post. A few of these benefits overlap with those I mention (above) as reasons I consume Berries & Herbs. But most of the eight benefits are unique:

1) TASTES GREAT

2) HIGHER RNA LEVELS THAN OTHER REJUVENATE!™ SUPERFOODS

3) CELL-SUPPORTING HERBS FOR OPTIMAL HEALTH

4) SLOWER DETOXIFICATION FOR A GENTLER DETOX EXPERIENCE

5) HIGH PROTEIN (ALL VEGETARIAN)

6) MULTIVITAMIN WITH COENZYME B COMPLEX FOR ADDITIONAL NUTRIENTS

7) HIGH ANTIOXIDANT VALUE (14,200+ ORAC) FOR REJUVENATING POWER

8) NRF2 ACTIVATORS SUPPORT ANTIOXIDANT PRODUCTION IN CELLS

These eight benefits create a profile of advantages specific to Berries & Herbs. I will discuss most of these benefits below.

HIGH LEVELS OF DIETARY NUCLEIC ACIDS (RNA, DNA)

Before I talk about how good Berries & Herbs tastes (and did I mention it tastes really good?), I want to present information about dietary nucleic acids.

Dietary nucleic acids are so important for health that Dr. Benjamin S. Frank devoted his entire life to studying them. He declared them to be “essential nutrients” for health like vitamins and minerals.

One way dietary nucleic acids (RNA, DNA) support health is by boosting production of energy (ATP) in the body. When ATP production is high, the body has sufficient energy to support many of the biological functions required for keeping you healthy.

Read more about health benefits of dietary nucleic acids in my article, “9 Things to Know About Rejuvenate! Superfoods” and other blog articles.

Inspired by Dr. Frank’s scientific writings, my father Dr. Hank Liers formulated the series of Rejuvenate! superfoods specifically with the idea of providing high levels of dietary nucleic acids (RNA, DNA) to support optimal health. All three Rejuvenate! superfoods provide at least 340 mg of dietary nucleic acids.

To be exact, Rejuvenate! (Original) and Rejuvenate! PLUS both provide 340 mg of dietary nucleic acids per serving. Rejuvenate! Berries & Herbs provides a whopping 390 mg of dietary nucleic acids!

That’s 50 mg more dietary nucleic acids per serving. As I noted, an extra 50 mg of dietary nucleic acids (Rejuvenate Berries & Herbs compared to other Rejuvenate! superfoods) may not seem like much, yet those servings add up.

At one serving daily, in a single week you will consume an “extra” 350 mg of dietary RNA (at 50 mg more per day). That is a full extra serving weekly. If you take two servings daily, that’s 700 mg additional dietary nucleic acids.

Dr. Frank tells us that a small amount dietary RNA goes a long way in terms of health benefits. He states that relatively small amounts of RNA (e.g., 100 mg daily) can provide noticeable health benefits.

Yet, larger amounts provide more benefits and create a stronger foundation for health (Frank 117). For example, individuals who benefit from larger amounts of RNA include athletes, individuals experiencing stress, and those seeking to recover from injuries.

An extra 350–700 mg dietary nucleic acids weekly can make a difference for health. It also means that a container Berries & Herbs can last longer than a container of Rejuvenate! PLUS in terms of providing more RNA per serving.

How much RNA do you need? That depends. 1,000 mg is a solid goal. That’s just two and one half (2.5) servings of Berries & Herbs or approximately five scoops.

HOW MUCH RNA DO WE NEED?

Dr. Benjamin S. Frank and other experts suggest an “optimal” intake in the range of 1,000–1,500 mg. This means 2.5 to 4 servings per day, or five to eight small scoops of Berries & Herbs. This amount can reasonably be attained by consuming, for example, a morning smoothie and an afternoon shake with three scoops of Berries & Herbs each.

After reaching a daily intake of about 1,500 mg, the benefits obtained by increased RNA consumption begin leveling. Greater intake of nucleic acids beyond this amount seems to provide fewer benefits.

An Olympic athlete in training might benefit from a daily RNA intake of 2,500 or 3,000 mg. Yet, most of us don’t have these high requirements because we aren’t pushing our bodies to such a level of activity and intensity.

That doesn’t mean you can’t gain similar benefits as those that might be conferred to an Olympian by optimizing your daily intake at a level that gives you sufficient dietary nucleic acids for rejuvenation, energy, and vitality.

Begin with a serving or two per day of Berries & Herbs (or another Rejuvenate! superfood), and work up to 1,000–1,500 mg daily.

GIVE IT TIME

It takes the body a few weeks to become saturated with nucleic acids. For me, it seems to be about 12 days.

Thus it can initially take two to four weeks after starting a high-RNA diet to see the benefits of nucleic acids. You may immediately notice greater energy or body warmth. (Likewise, when you stop taking nucleic acids, the benefits will still last several weeks.)

By consuming Berries & Herbs regularly after the body is saturated with RNA, you easily maintain your body’s supply of dietary nucleic acids. Maintaining your daily intake of dietary RNA helps sustain health.

INCLUDES HIGH-POTENCY MULTIVITAMIN WITH COENZYME B COMPLEX

A major benefit of Rejuvenate! Berries & Herbs is that it contains a high-potency multivitamin. Why is this important? While many people take a multivitamin, most multivitamins provide inadequate amounts of essential nutrients required for health.

In fact, many multivitamins provide the “Daily Value” established by the US government for critical nutrients. Daily values have replaced what was formerly known as “recommended daily allowances,” yet typically remain at or barely above levels required to prevent diseases of deficiency. These are not levels optimal for human health.

That is, daily values are not designed to create optimal health. They are minimum values based upon levels required for to avoid deficiencies. There is a huge difference between minimum levels needed for survival or prevent deficiencies. Indeed, the body assimilates and utilizes far higher levels to build and maintain robust health.

Still, the majority of multivitamins are formulated to provide minimum daily values. Thus, the majority of persons taking multivitamins obtain minimal values that do not create optimal health.

We at HPDI know the importance of a high-potency multivitamin for providing nutrients at levels that fall into ranges necessary for creating, supporting, and maintaining excellent health. After all, HPDI’s founder-formulator Dr. Hank Liers specializes in designing effective, high-potency multivitamins. He has done this for more than 25 years.

HPDI offer several excellent standalone multivitamins. But until the advent of Rejuvenate! Berries & Herbs, only HPDI’s Rejuvenate! PLUS superfood included a built-in multivitamin.

Dr. Liers wanted to confer the same nutritional advantages to consumers of Berries & Herbs. The vitamins added to HPDI’s superfoods like Berries & Herbs may not in every case completely replace the need for a standalone multivitamin. However, they do make the formula far more nutritious and more effective, partly helping the body better utilize dietary nucleic acids.

When it came to formulating Rejuvenate! Berries & Herbs, Dr. Liers not only incorporated a high-potency multivitamin, but also made sure the forms of these vitamins would be only the ones best used by the body.

Many of the vitamins (including the B complex vitamins) in Berries & Herbs are coenyzme-form vitamins or other forms best-recognized and/or utilized in the body. Best recognized almost always means natural. For example, Berries & Herbs does not include folic acid, which is a synthetic form of folate, but instead use calcium folinate (folinic acid), the natural co-enzyme form of folate.

Here are the vitamins in one serving that make up the multivitamin complex in Rejuvenate! Berries & Herbs:

• VITAMIN C (250 MG) (417% OF DAILY VALUE)

• VITAMIN E AS D-ALPHA TOCOPHERYL SUCCINATE (90 IU) AND HIGH GAMMA MIXED TOCOPHEROLS (25 MG) (300% OF DAILY VALUE)

• VITAMIN D3 (1,000 IU) (250% OF DAILY VALUE)

• VITAMIN K1 (0.5 MG) (625% OF DAILY VALUE)

• VITAMIN (100 MG)

• CHOLINE (50 MG)

• VITAMIN B1 FROM THIAMIN DIPHOSPHATE (7.5 MG) (500% OF DAILY VALUE)

• VITAMIN B2 FROM RIBOFLAVIN-5′-PHOSPHATE (6.8 MG) (400% OF DAILY VALUE)

• VITAMIN B3 AS NIACINAMIDE (60 MG) (300% OF DAILY VALUE)

• VITAMIN B5 AS PANTOTHENIC ACID (30 MG) (300% OF DAILY VALUE)

• VITAMIN B5 FROM COENZYME PANTETHINE (13 MG) (130% OF DAILY VALUE)

• VITAMIN B6 FROM PYRIDOXAL-5′-PHOSPHATE (10 MG) (500% OF DAILY VALUE)

• FOLATE AS FOLINIC ACID (1 MG) (250% OF DAILY VALUE)

• BIOTIN (0.9 MG) (300% OF DAILY VALUE)

• VITAMIN B12 AS METHYLCOBALAMIN (0.2 MG) (3,333% OF DAILY VALUE)

This list of course does not include other vitamins in Rejuvenate! Berries & Herbs ingredients, such as nutrients found in vegetable sprout powders, vegetable protein powders, stabilized rice bran, or in many of the herbal ingredients like burdock, ginger, or turmeric.

Another advantage of coenzyme vitamins is the body needs less of any given coenzyme vitamin because it does not need to convert non-coenzyme vitamins into usable forms. Therefore, the body requires less of a coenzyme-form vitamin.

That is a good thing because it does not cause the body to waste energy using enzymes to convert synthetic vitamins into their coenzyme forms. While coenzyme vitamins are relatively expensive to source, they are often very affordable to consumers because the body only needs tiny amounts of them.

Unlike many conventional B vitamins typically used in multivitamins, there are no losses of coenzyme B vitamins in vivo (in the body) due to conversion processes because they are immediately recognized by the body. This represents a powerful boost in effectiveness for minimal rise in cost.

HPDI uses coenzyme vitamins in many of their products because of their high value in terms of health and well being. The future of vitamin supplements lies in coenzyme-form vitamins because they are the most natural and most effective, and the most easily assimilated by the body.

In fact, HPDI was among the first companies to incorporate coenzyme form vitamins into its formulas. Dr. Hank Liers understands their value for human health. We will continue formulating products with coenzyme vitamins like Rejuvenate! Berries & Herbs.

VITAMINS INCREASE EFFECTIVENESS OF DIETARY NUCLEIC ACIDS

The vitamins (including coenzyme-form vitamins) in Rejuvenate! Berries & Herbs provide a significant benefit. They boost the effectiveness of the dietary nucleic acids.

Dr. Benjamin S. Frank certainly was clear about the effects of vitamins on the human body, including its capacity for using dietary RNA for therapeutic purposes. In his regimen for using nucleic acids for health as documented in Dr. Frank’s No-Aging Diet, he recommends taking a “therapeutic-strength” multivitamin daily (76).

Dr. Frank performed many human and animal studies using dietary nucleic acids. He nearly always included vitamins in his regimens. Very often he placed subjects on separate B-complex supplements.

Dr. Frank specifically states that the addition vitamin B-complex to the RNA regimen enhances the effects of dietary RNA. For example, he mentions how the B-complex support the rejuvenating effects of RNA on facial skin (Nucleic Acid Nutrition and Therapy 27).

Dr. Frank often specifies additional vitamins for dealing with certain conditions. For example, in his chapter on how his no-aging diet can help with osteoarthritis, he recommends patients take an additional 250 mg of pantothenic acid (vitamin B5) and 500 mg of vitamin C.

In his writings on dietary recommendations, Dr. Frank not only recommends B-complex vitamins, but also vitamin A, vitamin C, and vitamin D. He also incorporates a wide range of minerals in his formulas for patients.

Minerals he recommends include magnesium, zinc, and potassium. He also mentions other nutrients, such as coenzyme Q (ubiquinone/ubiquinol), enzymes, amino acids (e.g., carnosine, glutathione), and natural sugars (e.g., ribose and deoxyribose).

The inclusion of a complete multivitamin complex in Rejuvenate! Berries & Herbs helps make dietary nucleic acids more effective.

Learn more about our complete line of foundational supplements, including multivitamins.

HIGH-ORAC NUTRITION & ANTIOXIDANT PROTECTION

Rejuvenate! Berries & Herbs is an excellent, well-balanced superfood. Few superfoods stack up against it when you consider all the nutrition it provides.

Which brings us to another benefit: High antioxidant values. Berries & Herbs is in a class by itself when it comes to providing antioxidant power. That is, the power to quench free radicals.

One measure of the antioxidant values of foods and nutrients is ORAC value. ORAC stands for “oxygen radical absorbance capacity.” An ORAC test measures antioxidant capacities in vitro (test tube).

ORAC by itself is not the only or necessarily the best measure of antioxidant value because the oxygen radicals are not the only oxidants. A more comprehensive test would be the ORAC5.0 test, which measures the free-radical quenching powers of a sample against five different types of oxidants.

Nevertheless, ORAC remains a useful guide to the oxidant quenching powers of a superfood. Berries & Herbs provides an ORAC value of greater than 14,270 units per 38.9 gram serving.

There exist few individual foods, for example, that exhibit an ORAC value anywhere close to this figure. Even the highest-ORAC foods (like prunes or blueberries) fall short, being at most one-third as effective.

Most individual berries provide ORAC values in the range of 5,000–7,000 units per 100 gram serving (usually one cup or eight ounces), which translates into about 50–70 ORAC units per gram. Berries & Herbs tops such figures by providing 367 ORAC units per gram.

This means the ORAC value provided by Rejuvenate! Berries & Herbs in a single two-scoop serving (about 5 tablespoons) equals the ORAC the average high-ORAC berry (about 60 ORAC units/gram) provides in about six one-cup servings (48 tablespoons).

Serving-for-serving, Berries & Herbs is greater than six times more potent as an antioxidant substance than most foods considered high-ORAC. It also means you’ll need to consume far less Berries & Herbs to gain the antioxidant benefits you would from a much larger quantity of high-ORAC foods.

Berries & Herbs offers 367 ORAC units per gram! One serving is about 39 grams, so there is a huge amount of free-radical quenching power in just a single serving.

How huge is that? Since Berries & Herbs provides 14,276 ORAC units per serving (38.9 grams), then for a typical 100 gram ORAC equivalency, it provides an ORAC value of 36,684. Most ORAC food charts stop at about 14,500 units per 100 g (and average high-ORAC foods hover at 5,000 units per 100 g) to put those values in perspective.

Gram for gram, Berries & Herbs offers more than twice the ORAC value of the highest ORAC foods. And at least five to seven times more ORAC value than “average” high-ORAC foods (strawberries, raspberries, and blackberries) providing 5,000–7,000 ORAC units per 100 grams).

Antioxidant power is a unique benefit for Rejuvenate! Berries & Herbs, and one that is hard to be matched by any superfood, anywhere.

HIGH-ORAC BERRIES & POLYPHENOLS

I will talk more about about antioxidant nutrients in Rejuvenate! Berries & Herbs when discussing its cell-protecting herb and nutrient blend.

The major free-radical quenching power Berries & Herbs actually lies in its berry and polyphenol content. The extraordinary free radical-quenching capacities of Rejuvenate! Berries & Herbs relate directly to the fact that berries, as well as plant-based polyphenols (like those found in grapes and grape extract) contain relatively large quantities of antioxidants.

Also, the berries and polyphenols in in the formula come in highly concentrated forms. For example, we include potent berry blends like VitaBerry® Plus® and a carefully selected organic freeze-dried berry complex. The blends provide many types of berries, polyphenols, and other antioxidant nutrients acting synergistically to create higher ORAC values than a formula with fewer types of these berries or polyphenols.

NRF2 ACTIVATORS

Many plant-based antioxidants also act as Nrf2 activators. Nrf2 is a transcription factor encoded in human genes and whose antioxidant response pathway is our primary cellular defense against oxidative stresses. Nrf2 increases expression of important antioxidant enzymes in cells.

What this means is that Nrf2 activators are substances that activate the cells’ own production of antioxidant defenses. Because there is significant overlap between the food-based (i.e., exogenous) antioxidants and Nrf2 activators stimulating the body’s production of its own antioxidant enzymes, the berry complexes and polyphenols in Rejuvenate! Berries & Herbs serve double-duty as externally supplied antioxidants and stimulators of the body’s own antioxidant production.

The study of Nrf2 activator nutrients is an exciting area of research due to the potential for Nrf2 activators to significantly boost human health by enabling the body to unlock its potential for creating antioxidants.

The body already produces its own antioxidant defenses, but Nrf2 activators significantly enhance this process, thereby allowing far greater production of antioxidants for cell protection.

Rejuvenate! Berries & Herbs was not formulated as a Nrf2 activator formula. Yet, research shows there is significant overlap among the antioxidant substances in Berries & Herbs and nutrients known for activating Nrf2 transcription factor.

Known Nrf2 activators in Rejuvenate! Berries & Herbs include vegetable sprouts powder, blueberry powder, cranberry powder, strawberry powder, raspberry powder, vitaberry plus, burdock root, astragalus, turmeric, ginger root, rhodiola rosea (root), rutin, n-acetyl-l-cysteine, milk thistle extract, licorice (root), green tea extract, dandelion root, vitamin E (d-alpha tocopherol), lipoic acid, grape extract, and transresveratrol.

To learn more about Nrf2 activators, please see “The Amazing Healing Potential of Natural Nrf2 Activators,” “Natural Phytochemical Nrf2 Activators for Chemoprevention,” and other Nrf2-related articles on HPDI blog.

HPDI also offers Ultimate Protector, which is an antioxidant, vitamin C, and Nrf2 activator formula in a capsule. Ultimate Protector is not a high-RNA superfood, but a standalone HPDI foundational supplement. The two formulas can be combined, and in fact are formulated so they can be taken together in the HPDI system. Six small capsules of Ultimate Protector provide 486,000 ORAC5.0 units per serving. When taken together, the two formulas product more than 500,000 ORAC5.0 units per serving.

As noted, Berries & Herbs is not formulated as an antioxidant or Nrf2 activator formula per se. Yet, it provides significant antioxidant and Nrf2 activation.

When any Rejuvenate! superfood (including Berries & Herbs) is combined with Ultimate Protector (or another vitamin C and antioxidant formula), a multivitamin (like Multi Two), and essential fats (like Essential Fats Plus E), all four types of foundational formulas work together to support optimal health. Read more about how HPDI’s foundational supplements system works to support optimal health.

CELL-SUPPORTING HERBAL COMPLEX (“SUBFORMULA”)

One of the top features provided by Rejuvenate! Berries & Herbs is a blend of foods, herbs, and nutrients that collectively constitute a “subformula” created to support cell function and optimal cellular health.

Because this cell-protecting subformula contains many proven ingredients, it may appear to be more nutrient-dense substances heaped on top of an already densely packed Rejuvenate! Berries & Herbs superfood.

But the cell-protecting blend is something totally different. It’s not related to nucleic acid content, or to the built-in coenzyme B vitamin complex, or the high-quality protein content. It is a groundbreaking, game-changing set of ingredients that sets Berries & Herbs apart from nearly every superfood, including other Rejuvenate! superfoods.

The truth is that today our cells are under constant attack by thousands of different stresses. They are bombarded by toxic chemicals in the air, water, and soil. These chemicals include everything from pesticides and herbicides to household cleaning chemicals and industrial contaminants.

Our cells are also attacked by radiation. For example, elevated levels due to nuclear accidents like Fukushima and high background levels remaining from nuclear tests. Not to mention exposures from medical and dental x-rays. All these exposures lead to cumulative damage.

Other cellular toxins include daily exposures to chlorine, fluoride, bromine, and other halogens. And of course, exposures to heavy metals like lead, mercury, and cadmium from numerous other sources like dental amalgams, old paint, contaminated fish, and many other sources.

There are many other toxins our cells must deal with daily. Rejuvenate! Berries & Herbs is formulated to help cells deal with this assault by providing nutrients that support optimal function. This includes supporting your antioxidant defenses, immune system, energy production system, detoxification, and other important functions.

Dr. Hank Liers initially created this subformula of ingredients at the request of veterinarian Randy Aronson, VMD, who is Dr. Liers partner in the development of the 2Docs line of pet wellness formulas (www.IntegratedHealth.com/2docs-pet-supplements.html).

Dr. Randy was looking for a potent combination of ingredients that could optimally support the health and vigor, as well as recovery from illness of many of his pet patients suffering from degenerative diseases. Dr. Hank’s formula worked for Dr. Randy’s animal patients.

Dr. Hank saw its potential benefits for people. He began thinking about what a human version of the formula might look like, and how it could be incorporated into a product. At the time, HPDI was developing it’s latest Rejuvenate!™ superfood. While formulating the superfood, Dr. Hank realized that these “herbs” and other nutrients could perfectly complement the “berries” he put in the formula. “Berries & Herbs” was born.

Rejuvenate! Berries & Herbs thus contains a cell-protecting blend of organic and/or wildcrafted herbs and antioxidants. The cell-protecting subformula includes the following ingredients:

Organic astragalus, organic burdock root, organic turmeric root, organic ginger root, n-acetyl-l-cysteine (NAC), k-rutin™, standardized milk-thistle extract (>82% silymarin), standardized green tea extract (>95% polyphenols, >55% EGCG), organic licorice root, organic dandelion root, organic dulse, organic kelp, standardized Rhodiola rosea root (>3% rosavins), alpha-lipoic acid, BioVin™ grape seed, skin, and pulp extract, Immune-Assist™ (synergistic blend of organic mushroom extracts including Agaricus blazei, Cordyceps sinensis hybrid, Lentinula edodes, Grifola frondosa, Ganoderma lucidum, and Coriolus versicolor), transresveratrol (from Polygonum cuspidatum), germanium sesquioxide, and l-selenomethionine.

This subformula of ingredients makes a Berries & Herbs almost a “stealth” superfood. That is, many of the other benefits are more directly evident. Like high level of vegetarian-friendly protein or a built-in multivitamin.

The inclusion of dietary nucleic acids may be more obviously beneficial than cell-protective nutrients. But the subformula of cell-protective nutrients and herbs offers major benefits.

A nutritionist might read the label and realize the immune-building power of the cell-protective subformula. An acupuncturist might see its capacity for increasing energy or “chi.” A naturopath may identify potential for detoxification. In fact, most health professionals recognize value in the subformula’s ingredients.

The cell-supporting subformula is effective for supporting immunity, energy production, and detoxification, and other healthy benefits. The herbs and nutrients in the cell-supporting subformula make Rejuvenate! Berries & Herbs unique, and distinguishes it from other superfoods.

BERRIES & HERBS IS A HIGH-PROTEIN SUPERFOOD

Beyond the advantages of Rejuvenate! Berries & Herbs discussed, you might think the benefits stop there. But here is another one: Berries & Herbs is a high-protein powerhouse.

Dr. Hank Liers designed Berries & Herbs not only as a great-tasting, well-rounded superfood with dietary nucleic acids, multivitamins and minerals, but also as a high protein formula.

Higher protein (12 g per serving) means more complete nutritional support for people using Rejuvenate! Berries & Herbs as a food, snack, or nutritious drink.

The 12 grams of protein in a single two-scoop serving of Rejuvenate! Berries & Herbs is about six rounded tablespoons of it.

It’s easy to consume two scoops at a time because it tastes so good. Whether you choose to mix it in a smoothie, shake it up in jar, drink it plain in water, or add to fresh juice, you can count on its protein to help sustain you.

Adult females require about 46 grams of protein per day. Two servings of Rejuvenate! Berries & Herbs provides a woman with more than half (52%) of her daily recommended intake of protein.

Adult males require more protein (about 56 grams daily) than females. But even for men, two servings of Berries & Herbs provide almost 43% of their recommended daily protein intake.

PROTEIN SUITABLE FOR VEGETARIANS

The high-quality protein in Rejuvenate! Berries & Herbs comes from non-GMO brown rice, organic sprouted flaxseed (powder), organic hemp protein (powder), and a blend of garden sprouts. Here is the breakdown of the major protein sources in Rejuvenate! Berries & Herbs:

• High Protein Organic Garden Sprout Blend (3,000 mg/serving). Included in this blend are pea protein, quinoa sprouts, broccoli sprouts, alfalfa sprouts, daikon radish sprouts, red clover sprouts, and natural vanilla favor. Greater than 65% protein.

• Brown Rice Protein (Non-GMO) (9,000 mg/serving)

• Flaxseed Powder (3,000 mg/serving) (15–30% protein)

• Organic Hemp Protein Powder with Fiber (3,000 mg/serving)

I will present more information (below) regarding specific nutritional information for each of these superior vegetable-based protein sources. Selenium (from l-Selenomethionine), and Vitamin D3 (cholecalciferol).

FINAL WORDS: TASTE, TASTE & TASTE!!

I rarely save best things for last. But while delicious taste may not be a health benefit, it qualifies as one of the outstanding features of Rejuvenate! Berries & Herbs.

Berries & Herbs has a beautiful aroma and flavor that tickles taste buds with intense berry flavors and lingering fruity notes. Its taste is like a blast of berries in the mouth probably because that’s exactly what it is.

Most people like it. I myself was astonished that a superfood could taste so good.  If you haven’t tried it before, you’re likely to be pleasantly surprised.

Below I include detailed information about Rejuvenate! Berries & Herbs. Here is a superfood you can rely on for solid nutrition, great taste, and high levels of dietary nucleic acids supporting optimal health. ~

rejuvenate! berries & herbs high-RNA superfood

Rejuvenate! Berries & Herbs is a Dr. Hank Liers “original” formula.

DETAILED INFORMATION ABOUT REJUVENATE!™ BERRIES & HERBS

REJUVENATE!™ BERRIES & HERBS CONTAINS THE FOLLOWING UNIQUE INGREDIENTS

VitaBerry® Plus® (400 mg/serving)

VitaBerry® Plus® is a nutritious ingredient having extremely high ORAC value and is derived from freeze-dried Grape Seed, Wild Blueberry, Wild Bilberry, Cranberry, Tart Cherry, Prune, Raspberry Seed, Strawberry, Resveratrol, and Quercetin. In fact, this powder has an ORAC value in excess of 1.2 million units per 100 grams. Therefore at the 400 mg level that this material is found in Rejuvenate! Berries & Herbs it provides a minimum of 4,800 ORAC units. Because excessive exposure to free radicals may cause severe pain and inflammation, high-ORAC VitaBerry® Plus® significantly can contribute to preventing oxidative damage in the body.

VitaBerry® Plus® provides the following benefits:

• Superior source of natural antioxidants

• Helps prevent the effects of premature aging

• Promotes cardiovascular health

• Promotes healthy brain function and mental acuity

• Promotes healthy vision

• Promotes healthy blood sugar levels

• Excellent source of flavonoids and organic acids

• Promotes urinary tract health

• Promotes healthy skin

ORGANIC FREEZE-DRIED BERRY COMPLEX (6,000 mg)

The freeze-dried berry complex in Rejuvenate! Berries & Herbs is a proprietary blend of organic strawberries, raspberries, blueberries, and cranberries. Berries contain many powerful phytochemicals that can improve health. They are high in fiber and relatively low in sugar, and will not lead to surges to insulin when eaten in moderation.

BLUEBERRIES

The berries of the blueberry plant (Vaccinium angustfolium) exhibit among the highest levels of antioxidant activity of all fruits and vegetables. In particular, they contain the polyphenol anthocyanin (a pigment that gives fruits their red, purple and dark blue colors).

Anthocyanins are powerful flavonoid antioxidants that help protect the body from free radical damage and diseases associated with aging. Blueberries contain not only 25-30 different types of anthocyanins, but also chlorogenic acid (believed to be a tumor inhibitor), and the pigment cyanidin (an anti-inflammatory).

Blueberries contain silicon (an element believed to be helpful for the pancreas) and are considered to be helpful for diabetes.

Blueberries also have been effective for many health conditions, and may protect the body against age related declines in neural and cognitive functions, short-term memory loss, macular degeneration of the retina, and urinary tract infections (due to compounds that inhibit the adherence of bacteria to uroepithelial walls).

There is evidence that blueberries may improve glucose metabolism via the action of chlorogenic acid, serve as a powerful anti-inflammatory agents (useful against arthritis and other inflammatory conditions), and reduce the risk of tumorigenesis.

The antioxidant power of foods is measured in ORAC units (Oxygen Radical Absorbance Capacity), which indicate the total amount of a food’s antioxidant capacity. High ORAC values indicate greater antioxidant capacity. High-ORAC foods may therefore protect cells from oxidative damage.

Two studies have shown that eating high-ORAC fruits and vegetables (or doubling the intake of fruits and vegetables) elevates the antioxidant capacity of the blood 13-25% (see Jrnl of Clinical Nutrition 68: 1081-87).

When ORAC values for 40 fruits and vegetables were measured by the USDA’s Agricultural Research Service at its Human Nutrition Research Center on Aging (HNRCA) at Tufts University, fresh blueberries scored the near the top, having 2,400 ORAC units per 100 grams (3.5 ounces).

Serum levels of anthocyanins found in blueberries have been shown to rise significantly after ingestion of freeze-dried blueberry powder and correlate with an increase in serum antioxidant capacity as measured in ORAC units (Mazza et al., Jrnl of Agricultural and Food Chemistry 50 (26): 7731-37; 2002)

CRANBERRIES

Cranberries (Vaccinium macrocarpon) are native to the boggy regions of temperate and subalpine North America and Europe. Although Native Americans used them extensively, they were first cultivated in the U.S. in the early 19th century. Cranberries grow on viney plants belonging to the heath family Ericaceae that also includes blueberries, bilberries, huckleberries, and bearberries (Arctostaphylos uva ursi).

Cranberries contain tannins, fiber, anthocyanins (and other flavonoids), and Vitamin C. Their tannins prevent bacteria from attaching to cells. Consequently, cranberries have been used against infections, including urinary tract infections. In addition, cranberries may be helpful in protecting against heart disease and stroke.

Cranberries are an especially good source of antioxidant polyphenols. In animal studies, the polyphenols in cranberries have been found to decrease levels of total cholesterol and so-called “bad” cholesterol. Cranberries may also inhibit the growth of tumors in human breast tissue and lower the risk of both stomach ulcers and gum disease.

RASPBERRIES

Raspberries (and blackberries) belong to the rose family (Rosaceae). The red raspberry was first cultivated in Europe about 400 years ago. There are several varieties native to North America, including a black raspberry native to southern states (that has been crossed with European varieties) and a red raspberry (Rubus idaeus) from which originate most commercially grown varieties.

Raspberries contain anthocyanins, fiber (including the cholesterol lowering soluble form pectin), phytochemicals (ellagic acid, coumaric acid, ferulic acid), calcium, and vitamins A, C, and E. Ellagic acid is known to be antiviral, antibacterial, anticarcinogenic, and antimutagenic. It has been shown to inhibit the mutation of cells and to prevent the binding of carcinogens to DNA.

Raspberries have 1,220 ORAC units per 100 grams (3.5 ounces), among the highest of the forty fruits and vegetables tested by the USDA.

STRAWBERRIES

Strawberries long have grown wild in the world’s temperate regions. They have been cultivated for several thousand years and were prized among the ancient Romans. Most of the common varieties of strawberry derive from a hybrid (Frangaria x ananassa).

Strawberries have an ORAC value of 1,540, which is very high among the fruits and vegetables tested by the USDA. They are a good source of vitamins C, K, B2, B5, B6, and folate. They also contain appreciable amounts of the minerals manganese, iodine, and potassium, as well as dietary fiber. Like other berries, the antioxidants contained in strawberries may be useful against diseases of the heart and arteries by preventing the oxidation of lipids.

The phytonutrient phenols most abundant in strawberries are anthocyanins and ellagitannins. The anthocyanins help to prevent oxidative damage from free radicals in body. The unique phenol profile of the strawberry enables it not only to protect the heart, but also to fight inflammation.

Studies have shown strawberries protect the brain from oxidative stress and may therefore reduce age-related cognitive decline in brain function.

CELL PROTECTIVE ORGANIC & WILDCRAFTED HERBS AND ANTIOXIDANTS

ORGANIC ASTRAGALUS POWDER (200 mg)

Astragalus is derived from the root of a plant (Astragalus membranaceus) in the pea family. It is an adaptogen, meaning it has a balancing effect on bodily functions. Astragalus is often used to strengthen or tone the body’s overall vitality, improve digestion, and support the spleen. Studies confirm it contains biologically active compounds, including a polysaccharide that stimulates the immune system.

ORGANIC BURDOCK ROOT (200 mg per serving)

Burdock root is one of the foremost cleansing herbs, providing nourishing support for the blood, the liver, and the natural defense system. It is rich in Vitamins B1, B6, B12, and E, as well as manganese, copper, iron, zinc, sulfur, and more. Burdock root is often found in tonic formulas and special blends designed for internal cleansing.

In traditional herbal texts, Burdock root is described as a “blood purifier” or “alterative” and was believed to clear the bloodstream of toxins. During the industrial revolution, Burdock was used as a medicine to help people cope with the increasing environmental pollution.

Burdock root has been used both internally and externally for eczema and psoriasis, as well as to treat painful joints and as a diuretic. In traditional Chinese medicine, burdock root, in combination with other herbs, is used to treat sore throats, tonsillitis, colds, and even measles. It is eaten as a vegetable in Japan and elsewhere. Burdock is a mild laxative. It also aids in the elimination of uric acid. The herb contains polyacetylenes that have both anti-bacterial and anti-fungal properties.

ORGANIC TURMERIC ROOT POWDER (150 mg per serving)

Turmeric, a polyphenol, contains substances called curcuminoids that are powerful antioxidants, pain relievers, and anti-inflammatories. Curcuminoids have been shown to exhibit antibacterial activity.

ORGANIC GINGER ROOT (150 mg per serving)

Ginger rhizome (Zingiber officinale) is an incredibly active and effective gastrointestinal aid with the following properties: 1) Contains a digestive enzyme whose effectiveness even exceeds that of papain; 2) Stimulates the flow of saliva and increases the concentration of the digestive enzyme amylase in the saliva; and 3) Activates peristalsis and increases intestinal muscle tone. Ginger is also known to be helpful in cases of nausea.

N-ACETYL-L-CYSTEINE (NAC) (100 mg per serving)

NAC is a powerful free radical scavenger. A majority of orally ingested NAC rapidly undergoes deacetylation to form L-cysteine, which is necessary for glutathione production. NAC, therefore, has powerful implications for immune function and increasing the body’s free-radical trapping capacity.

NAC’s effectiveness in treating patients with acetaminophen overdose is well documented. NAC has been used with good results in treatment of respiratory illness and diseases such as chronic bronchitis and chronic obstructive pulmonary disease. Additionally, NAC has well-known antimucolytic properties, and has been shown to increase mucociliary transport in lungs.

k-RUTIN™ (100 mg per serving)

Rutin (quercetin-3-rutinoside) is a glycoside of the flavonoid quercetin. The chemical structure of rutin and quercetin consequently are very similar. Indeed, both rutin and quercetin are used in many countries as medications for blood vessel protection, and both are found as ingredients in numerous nutritional supplement preparations and herbal remedies.

k-Rutin™ is an alkalinized form of rutin having greater solubility than the rutin included in traditional nutritional supplements. That is, based on laboratory studies, it is a more soluble anthocyanin moiety (functional group) than rutin.

RECOGNIZED HEALTH BENEFITS OF RUTIN

• Rutin inhibits platelet aggregation and decreases capillary permeability, which thins blood and improves circulation

• Rutin exerts anti-inflammatory activity

• Rutin inhibits aldose reductase activity. Aldose reductase is an enzyme normally present in the eye and elsewhere in the body. It helps change glucose into a sugar alcohol called sorbitol that is associated with cataract formation

• Rutin strengthens capillaries. It therefore can reduce symptoms of capillary- and circulatory-related health conditions, including hemophilia. It also may help prevent common venous edemas of legs and feet.

• Rutin can reduce cytotoxicity of oxidized LDL cholesterol and reduce the risk of heart disease

• Evidence indicates rutin can be used to treat hemorrhoids, varicosis, and microangiopathy

• Rutin acts as an antioxidant. A study of the superoxide anion scavenging activity of rutin and six other flavonoids (including quercetin, morin, acacetin, hispidulin, hesperidin, and naringin) showed rutin had the strongest scavenging activity.

• Rutin provides essential support molecules for Vitamin C absorption and helps prevent breakdown of Vitamin C in the body before it is metabolized

• Rutin is believed to stabilize the collagen matrix by preventing free-radical damage, thereby helping to maintain the health of the body’s collagen

Rutin is a flavonoid (or bioflavonoid) within a class of flavonoids that includes hesperidin, quercetin, eriodictyl, and citron. Rutin is essential for the absorption of Vitamin C.

While rutin in nature is found in many nutritious foods (e.g., citrus, red apples, teas, broccoli, onions), it is easily taken in supplement form. This is especially important because the body cannot produce flavonoids. They must be supplied through diet (and it is prudent to take them in supplemental form in order to maximize health).

Flavonoids boost the effectiveness of Vitamin C, improve eye health, strengthen capillaries, reduce cholesterol, improve blood circulation, and act as antioxidants. Recent studies indicate flavonoids may be a significant factor in guarding the body against infections and major illnesses.

MILK THISTLE EXTRACT (STANDARDIZED TO GREATER THAN 82% SILYMARIN) (100 mg per serving)

Extensive research has shown that silymarin – the major component of milk thistle extract – exerts both a protective and restorative effect on the liver and is able to stimulate the growth of new liver cells to replace old damaged cells.

GREEN TEA EXTRACT (STANDARDIZED TO GREATER THAN 95% POLYPHENOLS & GREATER THAN 55% EGCG) (100 mg per serving)

Green tea extract is used primarily for its free radical fighting capabilities. Its key ingredient, epigallocatechin gallate (EGCG), protects against digestive and respiratory infections. It helps block the tumor-promoting actions of carcinogens, ultraviolet light, and metastasis from an original site in the skin, stomach, small intestine, liver or lung. EGCG also reduces platelet aggregation about as much as aspirin.

Green tea is very effective in inhibiting pathogenic bacteria that cause food poisoning and increases levels of friendly intestinal bacteria. It also blocks the attachment of the bacteria associated with dental caries to the teeth.

ORGANIC LICORICE ROOT (100 mg per serving)

Licorice is a moist, soothing herb that is anti-inflammatory and expectorant, controls coughing and has hormonal and laxative effects. It is further used to prevent liver toxicity and to treat tuberculosis and adreno-corticoid insufficiency.

Licorice contains flavonoids, isoflavonoids, chalcones, and triterpene saponins, with the main being glycyrrhetinic acid with 24-hydroxyglycyrrhetinic acid (which is 100 times sweeter than sugar).

Licorice is used internally for asthma, bronchitis, coughs, peptic ulcer, arthritis, allergic complaints and after steroid therapy. It is said to accelerate the healing of peptic ulcers and is used in cases of adreno-corticoid insufficiency. It is also used in Chinese medicine to revitalize the heart and treat palpitations, boosting the spleen, for coughing and wheezing, as well as detoxifying the body and digestive system.

ORGANIC DANDELION ROOT POWDER (100 mg per serving)

Dandelion root enhances the flow of bile, improving such conditions as liver congestion, bile duct inflammation, hepatitis, gallstones, and jaundice.

ORGANIC NOVA SCOTIA DULSE (100 mg per serving)

The dulse in Rejuvenate! Berries & Herbs is hand-harvested, low-temperature sun-dried, and immediately milled into a fine powder. The entire harvesting and handling process follows strict organic standards to eliminate possible processing contamination. Analytical testing shows that our dulse contains approximately 30% minerals including over 30 minerals (includes many trace minerals).

ORGANIC ICELANDIC KELP (100 mg per serving)

The milled kelp (Laminaria digitata) in Rejuvenate! Berries & Herbs grows deep in the cold subtidal waters of northwestern Iceland. This kelp is the only commercially available kelp that is sustainably harvested, dried, milled and bagged following the organic standards of Quality Assurance International. It is also an excellent source of organic iodine.

RHODIOLA ROSEA ROOT (STANDARDIZED TO GREATER THAN 3% ROSAVINS) (100 mg per serving)

Rhodiola rosea (aka “Arctic root”) is categorized as an adaptogen due to its observed ability to increase resistance to a variety of chemical, biological, and physical stressors. It has a reputation for stimulating the nervous system, improving depression, enhancing work performance, improving sleep, eliminating fatigue, and preventing high altitude sickness.

Rhodiola species contain a range of antioxidant compounds, including p-tyrosol, organic acids (gallic acid, caffeic acid, and chlorogenic acid), and flavonoids (catechins and proanthocyanidins).

The adaptogenic properties, cardiopulmonary protective effects, and central nervous system activities of Rhodiola rosea have been attributed primarily to its ability to influence levels and activity of biogenic monoamines such as serotonin, dopamine, and norepinephrine in the cerebral cortex, brain stem, and hypothalamus.

ALPHA-LIPOIC ACID (75 mg per serving)

Alpha lipoic acid is normally made in the human body, where it functions primarily as an important metabolic nutrient. As such, it plays a crucial role in the metabolism of both fats and carbohydrates into energy. In addition, lipoic acid functions as an extremely powerful antioxidant capable of trapping many different types of free radicals in the body.

Because it is both water and fat soluble, lipoic acid can operate in a broader range of body tissues than most other antioxidants. Its small size allows lipoic acid to enter areas of the body not easily accessible to many other substances; this allows lipoic acid, for example, to enter the cell nucleus and prevent free-radical damage to DNA.

Because it is such a powerful antioxidant and can easily function and exist in both a reduced and oxidized state, lipoic acid can protect other important antioxidants such as glutathione, Vitamin E, and Vitamin C. Lipoic acid is also able to chelate heavy metals such as lead, cadmium, mercury, free iron, and free copper out of the body.

BIOVIN™ HIGH OPC GRAPE EXTRACT (PULP, SKIN, AND SEED) (50 mg per serving)

The BioVin™ grape extract in Rejuvenate! Berries & Herbs is extracted by ethanol and water and contains the highest percentage of OPCs of any product on the market. OPCs, a class of bioflavonoids, are one of nature’s most powerful free-radical scavengers.

As bioflavonoids, OPCs help to increase the effectiveness of Vitamin C. OPCs cross the blood-brain barrier to provide antioxidant protection to central nervous system tissue.

Studies have clearly demonstrated that OPCs improve and normalize capillary activity, strengthening capillary walls. OPCs bind to collagen fibers, realigning them in the process to a more youthful, undamaged structure. Elasticity, flexibility, and strength are thereby restored to connective tissue.

IMMUNE-ASSIST™ (40 mg per serving)

A combination of more than 200 different polysaccharides, derived from the enzymatic breakdown of complex organic plant material from six different species of medicinal mushrooms.

These mushrooms include Agaricus blazei, Cordyceps sinensis hybrid, Lentinula edodes, Grifola frondosa, Ganoderma lucidum, andCoriolus versicolor. Immune-Assist™ is made in the US using only USDA Certified Organic materials.

Immune-Assist is similar to other mushroom based polysaccharides in that it is formulated through an enzymatically activated process whereby complex cross-linked polysaccharides from vegetable sources are converted to biologically active immunomodulators composed of simpler sugars such as arabinose and xylose.

Immune-Assist™ does contain simple polysaccharides, but it also contains much more complex polysaccharides, including cross-linked beta mannans and beta-glucans, and hetero-polysaccharides which combine both alpha- and beta-bound monosaccharides in the same molecule. These complex polysaccharide compounds are not found in earlier-generation bran-based supplements like AHCC. This is the reason that Immune-Assist™shows such a greater range of immuno-modulation bioactivity than any other bran-based supplements.

Immune-Assist™ not only contains arabinoxylane, but also lentinan, grifolan (Dr. Nanba’s original Maitake D-Fraction), PSK and PSP, and active hemicellulose correlated compound (AHCC).

TRANS-RESVERATROL (FROM POLYGONUM CUSPIDATUM) (10 mg per serving)

Trans-resveratrol provides anti-oxidant protection, boosts cellular energy, and balances the immune system. It has been proven in studies to activate the SIRT1 longevity gene and enhance cellular productivity. Several research studies have shown that trans-resveratrol significantly modulates biomarkers of bone metabolism, inhibits pro-inflammatory enzymes such as COX-1 and COX-2, and exhibits chemopreventive agents, anticarcinogenic properties, cardioprotective effects, neuroprotective properties, and caloric restrictive behavior. Trans-resveratrol has shown the ability to increase the number of mitochondria thereby increasing total daily energy.

Studies have shown that trans-resveratrol promotes an increase in mitochondrial function, that translates into an increase in energy availability, improved aerobic capacity, and enhanced sensorimotor function.

GERMANIUM SESQUIOXIDE (15 mg per serving)

Germanium sesquioxide shows considerable promise in immune support by boosting levels of gamma interferon in a dose dependant fashion. Studies indicate that germanium sesquioxide may be effective in combating certain viral and malignant conditions. Other studies suggest benefits toward free radical damage, cataracts, hypertension, and osteoporosis.

SELENIUM (from L-SELENOMETHIONINE) (25 mcg per serving)

Selenium is a trace mineral required in the body. Its primary function is carried out in the form of selenomethionine, which is incorporated into four active sites of the enzyme glutathione peroxidase. This enzyme protects the body against free-radical damage (especially when it occurs in cell membranes) caused by the oxidation of unsaturated fatty acids.

Selenium historically has been linked to Vitamin E because Vitamin E blocks the production of oxidized fatty acids in cell membranes. Selenium also appears to exert antioxidant activity by itself. Selenium is involved in the production and utilization of thyroid hormone, and it is antagonistic to heavy metals, including lead, mercury, aluminum, and cadmium.

According to a publication of the National Research Council (NRC), “One could reasonably suppose that selenium is involved [e.g., exerts a protective function] in such human medical problems as cataracts, diseases of the liver, cardiovascular or muscular diseases, and the aging process.” Selenium in its vital role in glutathione peroxidase affects all components of the immune system, including the development and function of all white blood cells.

HIGH PROTEIN GARDEN SPROUT BLEND (3,000 MG PER SERVING)

For thousands of years individuals have been using the healing power of vegetable sprouts. When a dormant seed begins to sprout, it enters a stage of tremendous vitality. Antioxidants and enzymes are produced that protect the developing plant and enable rapid growth.

Exciting new research has identified the role of glucosinolates and iosthiocyanates (classes of phytochemicals inherent in sprouts) that appear to positively influence metabolism in the human body.

Studies have suggested that sprout phytonutrients can promote the maintenance of healthy organs, healthy anti-inflammatory conditions, reduce the effects of toxins, and help to fight the effects of age-related free-radical activity.

The specific blend of sprouts used in Rejuvenate! Berries & Herbs was chosen to provide all of the above benefits while also yielding a blend with greater than 65% protein. Included in this blend are pea protein, quinoa sprouts, broccoli sprouts, alfalfa sprouts, daikon radish sprouts, red clover sprouts, and natural vanilla favor.

BROWN RICE PROTEIN (NON-GMO) (9,000 MG PER SERVING)

The rice protein in Rejuvenate! Berries & Herbs is extracted using a proprietary enzyme process starting from non-genetically modified rice. Our rice protein is processed without the use of acids, bases or other chemicals. In addition, the protein content of the extracted product is over 70%. That is substantially higher than other extraction methods (less than 53%) that leave a much higher percentage of carbohydrate in the end product. The protein of brown rice contains all of the essential amino acids, but it is somewhat low in the amino acid lysine. For this reason we have added supplemental lysine (400 mg/serving) to the formula.

FLAXSEED POWDER (3,000 MG PER SERVING)

Flax seeds (Linum usitatissimum L.) contain essential fatty acids (an excellent vegetarian source of omega-3 alpha-linolenic acid), protein, soluble fiber, insoluble fiber, antioxidant lignans, minerals, and vitamins. Lignans are a phytoestrogens considered to be antioxidants. Flax seeds contain among the highest levels of lignans among all plant foods.

Whole flax seeds are an excellent nutritional food. However, whole flax seeds can be difficult to digest and its nutrients typically are poorly absorbed. Flax seeds contain natural enzyme inhibitors that prevent digestion. This natural protective mechanism means that a seed may be eaten, pass through the body, and still grow into a plant (i.e., completely surviving the digestive process!).

Milling or grinding the seeds does not decrease natural enzyme inhibitors that reduce the bioavailability of flax. Only sprouting decreases natural inhibitors that otherwise will prevent complete digestion, absorption, and assimilation of flax seeds.

Flaxseed Powder provides an ideal solution to maximize health benefits of flax seeds. The process of germination fundamentally changes nutrient composition of the seed.

Nutrients including enzymes, amino acids, and vitamins substantially increase and become more bioavailable. This allows for better availability and absorption of these nutrients in the body. For example, sprouting flaxseed doubles antioxidant (ORAC) value. In addition, “anti-nutrients” such as phytic acid, enzyme inhibitors, and insoluble fibers all decrease. This further increases bioavailability and nutrient absorption of flax, and thereby boosting the health benefits attainable from consuming it.

The flaxseed powder in Rejuvenate! Berries & Herbs contain oil amounts varying between 38–45%, with the oil offering a high percentage (47–53%) of the omega-3 alpha-linolenic acid (ALA) and 15–18% omega-6 linoleic acid.

Alpha-linolenic acid (ALA) is an essential fatty acid acting in the human body as a substratum for the transformation into EPA and DHA through the action of desaturation and elongation enzymes. The seeds also contain some omega-6 essential fatty acids and exhibit a favorable omega-3 to omega-6 ratio of 3:1. Modern diets contain too few omega-3 fatty acids.

Flaxseed powder possess 15–30% protein (typically 20%) and the amino acids of flax protein have no limiting factors in the adult diet (i.e., they are a complete protein source having all of the essential amino acids in an appropriate balance). Flax seeds are also a source of magnesium, calcium, potassium, phosphorus, zinc, and copper. They also have demonstrated antioxidant activity. The most important antioxidants they provide are phytoestrogens known as lignans.

The human body easily digests flax seeds. The seed’s outer layer is rich in mucilloid soluble fiber (flax seed possesses 10–15% soluble fiber) and absorbs at least four times its weight in water. When mixed with water or stomach juices, the seeds form a gel that creates a physical barrier between the carbohydrates and the digestive enzymes that break them down. The carbohydrates thereby are digested and converted into glucose (blood sugar) at a slow, uniform rate. There is no insulin surge or spike needed to lower the blood sugar level. The water-retaining capacity of the gel also maintains bodily hydration (i.e., helping level out water intake) and electrolyte balance.

ORGANIC HEMP PROTEIN POWDER WITH FIBER (3,000 MG PER SERVING)

We have chosen to include certified organic hemp protein with fiber in Rejuvenate! Berries & Herbs. This raw whole food protein powder is rich in complete protein, branch chain amino acids, omega 3 and 6 essential fatty acids and healthy dietary fiber. Our certified organic hemp protein powder is cold milled from certified organic hemp seed and contains contains 37% protein, 43% fiber and 10% fat. The product contains no genetically modified organisms, no additives or preservatives, no THC, and is kosher certified.

A MULTIVITAMIN WITH COENZYME B-COMPLEX

We have added the following vitamins to the formula: Vitamin C (250 mg), Vitamin E as d-alpha tocopheryl succinate (90 IU) and high gamma mixed tocopherols (25 mg), Vitamin D3 (1,000 IU), Vitamin K1 (0.5 mg), inositol (100 mg), choline (50 mg), calcium pantothenate (30 mg), niacinamide (60 mg), pantethine (13 mg), pyridoxal-5′-phosphate (10 mg), thiamin diphosphate (7.5 mg), riboflavin-5′-phosphate (6.8 mg), calcium folinate (1 mg), biotin (0.9 mg), and methylcobalamin (0.2 mg).

While coenzyme vitamins usually cost significantly more than the synthesized vitamins (up to 50 times more), they remain quite affordable because they are only required by the body in very small amounts. That is, the body only needs small amounts because there are no in vivo losses related to any conversion processes. We therefore include coenzyme form vitamins in Rejuvenate! Berries & Herbs in quantities helpful to the body.

The inclusion of coenyzme forms of vitamins significantly contributes to making our supplement formulas more effective than if we used conventional (i.e., non-coenzyme form) vitamins. Moreover, it increases effectiveness without substantially raising our costs. Thus, the benefits considerably outweigh the costs, especially for individuals who consume our formulas, thereby reaping the benefits coenzyme vitamins offer for human health and well being.

ENZYMES TO ENHANCE NUTRIENT UTILIZATION

The complexity and significant amounts of proteins and peptides found in Rejuvenate! Berries & Herbs requires the combination of multiple proteases to optimize digestion. Proteins are made up of over twenty different amino acids, with each combination presenting different characteristics. Each of the proteolytic enzymes in Rejuvenate! Berries & Herbs offers different abilities to break the chemical bonds found in the proteins. However, the combination of enyzmes shows the greatest rate of hydrolysis.

Peptidase breaks amino acids off the ends of the peptide chain. Our proprietary enzyme complex contains both amino-peptidase and carboxy-peptidase activities, and therefore it can remove amino acids from both ends of the peptide chain. Protease 4.5 breaks bonds at points within the peptide chain dependent upon their bond specificities. Significant action of this enzyme has been seen both in the laboratory and in digestive product usage. Protease 4.5 has an optimal pH of 4.5 (pH range 2.0 to 6.0). Protease 6.0 has an optimal pH of 6.0 (pH range 4.0 to 11.0). Together these proteases provide proteolytic action throughout the human digestive system.

Because Rejuvenate! Berries & Herbs contains a large amount of plant-based ingredients, we have added the enzyme cellulase to the formula. Cellulase offers distinct advantages for individuals consuming large amounts of vegetable matter. This enzyme hydrolyzes the bonds in various fibers. Cellulase hydrolyzes glucose-glucose bonds in cellulose. By disrupting the structure of the fiber matrices that envelop most of the nutrients in plants, cellulase increases the nutritional value of fruits and vegetables.

PREBIOTICS AND TASTE ENHANCERS

Rejuvenate! Berries & Herbs includes inulin (from chicory root), xylitol (from organic hardwoods), mannitol (a powerful superoxide free-radical trapper), malic acid (a Krebs cycle intermediate), organic mixed berry flavoring, organic vanilla flavoring, and stevia leaf extract. We include these ingredients in order to provide prebiotics, enhanced taste, and various health benefits.

ORGANIC ALOE VERA EXTRACT

We demand high-quality source materials containing the most biologically active and effective ingredients available. The aloe vera selected for Rejuvenate! Berries & Herbs meets our high standards. This aloe vera extract combines ground breaking research and state-of-the-art manufacturing to preserve and enhance aloe vera’s natural benefits in the form of ACTIValoe™, a standardized certified organic Aloe vera with 10% total polysaccharides by weight.

The purity and quality of ACTIValoe™ is verified by scientific analysis (i.e., Proton NMR Analysis, HPLC, SEC, etc.) and is certified by the International Aloe Science Council for its content and purity. Furthermore, ACTIValoe™ is guaranteed to retain biological activity to help deliver the healing properties of Aloe vera.

Biologically active aloe is believed to reduce severe joint and muscle pain associated with arthritis, as well as pain related to tendinitis and injuries. When applied directly to the area of pain, aloe vera penetrates the skin to soothe the pain. Studies have also found that ingestion of biologically active aloe on a daily basis can help prevent and cause a regression of adjutant arthritis.

Aloe vera extract can relieve gastrointestinal problems and may be one of the plant’s most ancient uses. Even today, people consume aloe vera to help relieve ulcerous, gastrointestinal and kidney problems. People have described improved regularity, greater intestinal comfort and enhanced energy levels after ingesting biologically active aloe vera. In addition, many who have suffered from indigestion, irritable bowel syndrome, increased stomach acid, peptic and duodenal ulcers, and colitis report relief from these conditions following ingestion of aloe vera.

Coronary heart disease is one of the major causes of death in the US. However, studies suggest that the ingestion of aloe vera may have a beneficial effect on the accumulation of blood fat lipids associated with the disease.

Test groups given aloe vera showed a decrease in total cholesterol, triglyceride, phospholipid, and nonesterified fatty acid levels, each of which, when elevated, seem to accelerate the accumulation of fatty material in large and medium-sized arteries, including the coronary arteries of the heart.

REJUVENATE!™ BERRIES & HERBS CONTAINS THESE INGREDIENTS FOUND IN HPDI’S REJUVENATE! (ORIGINAL) FORMULA

CHLORELLA GROWTH FACTOR (CGF) (200 MG PER SERVING)

In the early 1950s, the Japanese researcher Fujimaki separated a previously undiscovered substance from a hot-water extract of chlorella that is now known as “Chlorella Growth Factor” (CGF). CGF is a nucleotide-peptide complex comprised mostly of nucleic acid derivatives.

The sugars identified in the nucleotide include glucose, mannose, rhamnose, arabinose, galactose, and xylose. Amino acids found in the peptide include glutamine, alanine, serine, glycine, proline, asparagine, threonine, lysine, cysteine, tyrosine, and leucine.

It is known that CGF is produced during intense photosynthesis and enables chlorella to grow extremely rapidly. During this process, a single cell may multiply into four daughter cells as rapidly as every 20 hours. CGF not only promotes this rate of reproduction, but also is itself rapidly increased.

In Japan, Dr. Yoshiro Takechi showed that CGF stimulates lactobaccilus (the “good” bacteria) to grow at four times the usual rate. Experiments with microorganisms, young animals, and children have demonstrated that CGF promotes faster than normal growth. In adults and mature organisms, CGF appears to enhance the functions of nucleic acids at the cellular level that relate to the production of proteins, enzymes, and energy, as well as to stimulate tissue repair and offer protection against toxic substances at the cellular level.

D-RIBOSE (2,000 MG PER SERVING)

D-Ribose (ribose) is a sweet, crystalline, water-soluble powder. It is a naturally occurring 5-carbon sugar found in all living cells. Ribose is a component of RNA and therefore essential for living creatures. It is also a component of ATP, NADH, and other metabolism-related substances.

The biological importance of ribose relates to the fact that it is the rate-limiting compound that regulates the activity of the purine nucleotide pathway of adenine nucleotide metabolism. As such, ribose plays a central role in the synthesis of ATP, coenzyme-A, flavin adenine dinucleotide (FAD), nicotinamide adenine dinucleotide (NAD), DNA, RNA, and other important cellular constituents.

Ribose is the only known compound the body can use for performing this critical metabolic function. Specifically, ribose administration bypasses the slow and rate-limited pentose phosphate pathway to stimulate adenine nucleotide synthesis and salvage in vivo. In addition, it has been shown that de novo adenine nucleotide synthesis in skeletal muscle is rate limited by the availability of ribose.

D-ribose is commonly found in foods, especially foods high in RNA (ribonucleic acid), such as brewer’s yeast. D-ribose is essential for life and can be made by the body (e.g., from glucose). However, d-ribose from food sources can significantly boost the amount of ribose available to the body, thereby enhancing processes that utilize it.

Ribose derivatives play a significant role in the body. Important ribose derivatives encompass those having phosphate groups attached at the 5 position, including mono-, di-, and triphosphate forms, and 3-5 cyclic monophosphates. Diphosphate dimers, known as coenzymes, form an essential class of compounds with ribose. When such purine and pyrimidine derivatives are coupled with ribose, they are known as nucleosides(bases attached to ribose). Phosphorylated nucleosides are known as nucleotides. When adenine (a purine derivative) is coupled to ribose it is known as adenosine. ATP is the 5′-triphosphate derivative of adenosine. (The adenine portion of ATP consists of ribose and adenine. The triphosphate portion of ATP consists of three phosphate molecules.)

Ribose therefore is found in many important biological molecules, including adenosine triphosphate (ATP), nucleotides and nucleotide enzymes, and in RNA. D-ribose (as ribonucleoside diphosphates) notably converts to deoxyribonucleoside diphosphates, precursor molecules for DNA.

Ribose generates adenosine triphosphate (ATP) in the body. Supplemental ribose increases the rate at which ATP is generated, thereby improving exercise performance and enabling faster muscle growth. This is possible because supplemental ribose enables the body to bypass the conversion steps needed to create or re-create the adenosine nucleotide. Replacing adenine nucleotides normally takes time for the body to accomplish, and this process can reduce the rate of healing and repair (e.g., of muscle fibers). Supplemental ribose essentially increases the speed at which adenosine nucleotides can be replaced by providing raw material for the creation of more ATP.

Ribose similarly has been shown to boost synthesis and salvage of other nucleotides in the body, including those found in heart and skeletal muscle. Supplemental ribose again bypasses the rate-limiting conversion processes (i.e., of the pentose phosphate pathway), thereby speeding syntheses of nucleotides that provide energy to these tissues.

RIBOSE AS A SIGNIFICANT COMPONENT OF NUCLEIC ACIDS

Nucleotides are the molecular building blocks of DNA and RNA. They are chemical compounds consisting of a heterocyclic base, a 5-carbon sugar (ribose or deoxyribose) and at least one phosphate group. They are the monomers of nucleic acids, and 3 or more can bond together to form a nucleic acid.

Nucleosides are glycosylamines consisting of a base (or nucleobase) to a ribose (or deoxyribose) ring. Some nucleosides are cytidine, adenosine, guanosine, and inosine. When nucleosides are phosphorylated in cells, they produce nucleotides (see above).

Given the importance of ribose as an essential part of nucleic acids, nucleotides, nucleosides, its role in the production of energy (as ATP), and its ability to increase synthesis and salvage of nucleotides in the body, the inclusion of ribose in a formula designed to provide high levels of nucleic acids appears especially appropriate.

NUTRITIONAL YEAST (1,500 MG PER SERVING)

Nutritional yeast belongs to the same family of organisms as edible mushrooms. It may be considered man’s oldest industrial micro-organism. For more than 50 years, our supplier has been manufacturing primary grown nutritional yeast (Saccharomyces cerevisiae), grown specifically for its nutritional value. After the fermentation process is completed the yeast is harvested, thoroughly washed, pasteurized, and dried on roller drum dryers. The special growth medium and unique drying process are the secrets to the exceptional performance of the nutritional yeast in our product.

The result is a high-quality non-GMO product containing protein (approximately 48%) composed of essential and non-essential amino acids, dietary fiber, B-complex vitamins, and minerals such as selenium, chromium, potassium, magnesium, sodium, copper, manganese, iron, and zinc.

Nutritional yeast is extraordinarily rich in nucleic acids. In fact, nutritional yeast contains approximately 6% RNA among the highest of known foods.

In Dr. Frank’s protocols described in his book Nucleic Acid Nutrition and Therapy he used both nutritional yeast and high RNA extracts of nutritional yeast to obtain healing and regeneration.

Furthermore, nutritional yeast contains additional functional and beneficial components such as beta-1,3 glucan, trehalose, mannan and glutathione. Studies have show that these components have potential health benefits such as, improved immune response, normalization of cholesterol, and cellular normalization properties.

RICE BRAN SOLUBLES (2,000 MG PER SERVING)

Rice bran solubles are one of the most nutrient-dense superfoods available today. They derive entirely from rice. Specifically, they are a highly concentrated soluble carbohydrate and lipid-rich component of stabilized rice bran (i.e., a non-chemically modified water-soluble fraction). They are also a complete, great-tasting, natural source of B-complex vitamins (i.e., thiamin, niacin, vitamin B6) and contain many other nutrients, including amino acids, antioxidants, essential fatty acids, and phytonutrients, rice bran solubles are one of the world’s perfect whole foods, lacking only a few trace minerals.

In fact, our non-GMO rice bran solubles product offers at least 29 vitamins and minerals, and more than 90 antioxidants. Among these are lipoic acid (useful in blood glucose control), tocopherols, and tocotrienols (which may have a positive effect on cholesterol levels).

Alpha tocotrienol has been shown to provide up to fifty times more antioxidant power than alpha tocopherol. Rice bran solubles also contain essential fatty acids, including phospholipids, gamma oryzanol, ferulic acid, and phytosterols.

Certain antioxidants in rice bran solubles are documented as supportive in retarding the aging process and combating fee radicals. They strengthen the body’s ability to regenerate and increase energy and stamina.

Our producer of the stabilized brown rice bran in Rejuvenate! Berries & Herbs utilizes a process that reliably inactivates the lipase in rice bran while retaining the rest of the food’s chemistry. This is done with a mechanical extrusion process that forces the grain to deform as it squeezes through small openings in a metal die. The high rate of deformation during extrusion causes just the right amount of internal heating for the precise amount of time needed to inactivate the lipase. The result is a stabilized rice bran product that retains most of the vital nutrients of fresh rice bran, but has a shelf life measured in years rather than hours.

KEY NUTRITIONAL ELEMENTS IN RICE BRAN SOLUBLES

• Gamma oryzanol, beta sitosteryl ferulate, and five other related compounds. These are potent antioxidants and trace nutrients that play a vital role in many aspects of human physiology. Gamma oryzanol is found only in rice bran and has been used successfully in dealing with female hormone imbalances.
 Tocopherols and Tocotrienols – These include all of the eight known forms of Vitamin E including d-alpha tocopherol. The importance of the other forms is probably at least equal to the alpha form.

• Polyphenols, including ferulic acid, alpha-lipoic acid, and four other polyphenols. Lipoic acid plays an important role in sugar metabolism at the cellular level and is a powerful antioxidant. Ferulic acid also is a powerful antioxidant.

• Important minerals magnesium, calcium, and phosphorous, as well as manganese and other trace minerals. Minerals are involved in all of the enzyme functions of the body including those involved in energy production.

• Phytosterols, including beta sitosterol, campesterol, stigmasterol, and at least eleven more. Phytosterols have been shown to prevent the absorption of cholesterol, support healthy prostate function, and help to build immune function.

• Carotenoids, including beta-carotene, alpha carotene, lycopene, lutein, zeaxanthin, and more. Although beta-carotene is commonly sold as a single-ingredient supplement, alpha-carotene may in fact be more important. Lycopene is responsible for some of the recent health claims relating to tomatoes, and lutein and zeaxanthin play key roles in retinal function.

• Essential amino acids including tryptophan, histidine, methionine, cysteine, cystine, and arginine. Amino acids are the body’s basic materials for building all of its enzymes, DNA, RNA, and connective tissue.

• Nine B vitamins supporting the body’s metabolic machinery, polysaccharides (known among other functions to support immunity), and phospholipids. Phospholipids are vital to maintaining healthy cell membranes.

• Lecithin, which provides the important phospholipids phosphatidyl choline and phosphatidyl serine.

• Seven identified enzymes, including coenzyme Q10 and superoxide dismutase (an important antioxidant).

HIGH PHOSPHATIDE LECITHIN (98%OIL FREE, NON-GMO, FROM SUNFLOWER SEEDS) (1,500 MG PER SERVING)

In recent years, there is renewed interest in the health benefits and dietary requirements of lecithin. Growing evidence now suggests that dietary lecithin is important preventing many pathologic conditions. Lecithin is used as a dietary supplement for purpose of treating or preventing several human diseases, including cirrhosis of the liver, arteriosclerosis, and certain deficiencies of brain function and memory. In fact, the most recent research has shown that lecithin is an essential dietary component for ensuring optimal nutrition.

Lecithin and its component phosphatidyl choline are known to be essential for liver function. In fact, even a few weeks on a choline-deficient diet has been shown to cause abnormalities in liver function. Studies in primate models of alcohol-induced cirrhosis have shown that lecithin protects the body from alcohol liver damage. This is a particularly important finding because liver cirrhosis caused by excessive intake of alcohol is the fourth leading cause of death in people 25–64 years of age in the US.

Lecithin has also been shown to be essential for proper brain development in infants and children. Supplementing animal diets with lecithin at during specific times of brain development has been shown permanently to increase cognitive function.

MAGNESIUM

Magnesium is one of the most abundant, available metals on earth, and plays crucial roles in the sustenance of life and its chemical processes. The divalent nature of the magnesium cation makes it an ideal activator for enzyme systems. Estimates for its usage in human body systems include over fifty different biochemical reactions and its necessary presence for the operation of over 300 enzymes.

Magnesium is essential for energy production, maintenance of electrolyte balance, and neuromuscular function. Investigations into rates of magnesium deficiency show that individuals in developed countries are at remarkably high risk for magnesium deficiency.

The suspected primary cause of this risk for deficiency are inadequate, depleted diets that are high in processed foods (from which magnesium is removed but not replaced).

There are several nutritional requirements in the body in order for mitochondria to manufacture ATP. These essential nutrients include oxygen, magnesium, food substrate, ADP, and inorganic phosphate, as well as Vitamin B1, Vitamin B2, and Vitamin B6 in their phosphorylated coenzyme forms.

The body also needs adequate stores of malate (an important Krebs cycle intermediate) in order for most of these nutrients to function effectively in the process of ATP production. When any of these nutrients are not present in adequate amounts within the mitochondria, a vicious cycle can occur in which ATP is not created in amounts sufficient for proper cellular functioning.

Insufficient amounts of ATP mean that the B vitamins may not be adequately phosphorylated leading to improper metabolism and further reductions in ATP production. The much less efficient anaerobic production of ATP will be utilized to a greater extent in such cases.

A balance point may be reached in which the body produces only a fraction of the optimal amount of ATP. Under these conditions muscle weakness and fatigue may occur.

Abraham and Flechas report that supplementing the diet with magnesium may reverse such conditions of low energy (Jrnl of Nutritional Medicine 3: 49-59).

For the above reasons, we have included magnesium in Rejuvenate! Berries & Herbs from magnesium malate (providing both magnesium and malate) and magnesium ascorbate (providing additional magnesium as well as Vitamin C).

DULSE

Dulse is a sea vegetable (i.e., seaweed) that is a rich source of iron, potassium, iodine, Vitamin B6, riboflavin, and dietary fiber. It provides a wide range of minerals, trace elements, enzymes and phytochemicals, as well as some high-quality vegetable protein. Our certified organic raw dulse is sustainably harvested from well-protected coastal passages and low temperature dried.

FOLINIC ACID

Folinic acid, also known as 5-formyl tetrahydrofolate, is one active form in a group of vitamins known as folates. In contrast to folic acid, a synthetic form of folate, folinic acid is one of the forms of folate found naturally in foods. Folate deficiency is believed to be the most common vitamin deficiency in the world due to food processing, food selection, and intestinal disorders. In the body folinic acid may be converted into any of the other active forms of folate.

Folate coenzymes are responsible for the following important metabolic functions: 1) Formation of purines and pyrimidines which, in turn, are needed for synthesis of the nucleic acids DNA and RNA. 2) Formation of heme, the iron-containing protein in hemoglobin, 3) Interconversion of the 3-carbon amino acid serine from the 2-carbon amino acid glycine, 4) Formation of the amino acids tyrosine from phenylalanine and glutamic acid from histidine, 5) Formation of the amino acid methionine from homocysteine (Vitamin B12 as methylcobalamin also is needed for this conversion). Elevated levels of homocysteine have been implicated in a wide range of health disorders. In the reconversion of homocysteine to methionine the body uses the methionine to make the important amino acid s-adenosylmethionine (SAMe) which is known to be helpful in cases of depression, 6) Synthesis of choline from ethanolamine, 7) Formation and maturation of red and white blood cells, and 8) Conversion of nicotinamide to N’-methylnicotinamide.

METHYLCOBALAMIN (COENZYME FORM OF VITAMIN B12)

Methylcobalamin is one of two coenzyme forms of B12 (along with adenosylcobalamin) and can be used directly by the body without metabolic conversion.

Vitamin B12 is involved in numerous important body functions, including: 1) Red blood cell formation and control of pernicious anemia, 2) The synthesis and function of nerve tissue, such as myelin, 3) The metabolism of carbohydrates, fats, and proteins (Vitamin B12 is necessary for the conversion of methylmalonate to succinic acid, an important Krebs cycle intermediate in energy production), 4) The synthesis or transfer of single carbon units (e.g., allowing the interconversion of serine and glycine and the conversion of homocysteine to methionine), 5) Serving as a coenzyme in the biosynthesis of methyl groups, and 6) Involvement in reactions that convert disulfides (S-S) to the important sulfhydryl group (S-H).

COMPOSITION

REJUVENATE!™ BERRIES & HERBS CONTAINS:

Rice Protein, Vegetable Sprouts Protein (65% protein – organic), Hemp Protein with fiber (37% protein – organic), Flaxseed Powder, Rice Bran Solubles, D-Ribose, Blueberry powder (organic freeze dried), Cranberry powder (freeze dried), Strawberry powder (organic freeze dried), Raspberry powder (organic freeze dried), Nutritional Yeast (brewers yeast), Lecithin (98% oil free, high phosphatide, non-GMO, from sunflower seeds), Xylitol (from organic hardwood), Mannitol, Inulin/fructooligosaccharides (chicory root), VitaBerry Plus, L-Lysine (USP grade), Vanilla Flavoring (organic), Mixed Berry Flavoring (organic), RNA from yeast, Vitamin C (from Mg ascorbate), Chlorella Growth Factor (CGF), Burdock Root (organic), Astragalus Root (organic), Turmeric (organic), Proprietary Enzyme Blend (Protease, Peptidase, Cellulase), Ginger Root (organic), L-Malic Acid, Rhodiola rosea (root) (3% rosavins), k-Rutin™, N-Acetyl-L-Cysteine, Milk Thistle Standardized Extract (82% silymarin), Licorice (root) (organic), Kelp (organic), Dulse (organic), Inositol, Green Tea Extract (95% polyphenols), Dandelion Root (organic), Aloe vera (ActivAloe 200:1 – organic), Vitamin E (d-alpha tocopheryl succinate), Magnesium (from Mg malate), Stevia Leaf Extract, Lipoic Acid, Vitamin B3 (niacinamide), BioVin® Grape Extract, Choline (from bitartrate), Immune-Assist (organic medicinal mushrooms), Pantothenic Acid, Vitamin E (high-gamma mixed tocopherols), Vitamin B5 Pantethine, Germanium Sesquioxide, Resveratrol (from polygonum cuspidatum), Vitamin B6 (Pyridoxal-5′-phosphate), Vitamin B2 (riboflavin-5′-phosphate), Vitamin B1 (thiamin diphosphate), Magnesium (from Mg ascorbate), Biotin, Folinic Acid (from calcium folinate), Vitamin K1 (as phylloquinone), Vitamin B12 (as methylcobalamin), Selenium (from l-Selenomethionine), and Vitamin D3 (cholecalciferol).

BERRIES & HERBS IS ONE OF THREE REJUVENATE! SUPERFOODS

There are three unique superfoods in the Rejuvenate! line. They are Rejuvenate! (Original), Rejuvenate! PLUS, and Rejuvenate! Berries & Herbs. A complete side-by-side comparison of these superfoods is available.

SOURCES & RESOURCES

REVIEWS

“Rejuvenate! Berries & Herbs is Rich in RNA, Plant Proteins” (by Mike Adams, the Health Ranger)

“Rejuvenate!™ PLUS Superfood is High in DNA and RA with Sprouts, Chlorella and More” (by Mike Adams)

“Superfood for Cellular Survival” (by Dr. Mark Sircus)

HPDI BLOG ARTICLES

“9 Things to Know About Rejuvenate!™ Superfoods”

“High-RNA Rejuvenate!™ Superfood”

“Rejuvenate! – The Original, High-RNA Superfood”

“The Amazing Healing Potential of Natural Nrf2 Activators”

Review of Scientific Research on Oligomeric Proanthocyanidins (OPC)

DIETARY NUCLEIC ACIDS – DR. BENJAMIN S. FRANK, PART 1

DIETARY NUCLEIC ACIDS – DR. BENJAMIN S. FRANK, PART 2

Super-Tasty Morning Nutritional Drinks

Superfood Bars with Rejuvenate! Berries & Herbs

BOOKS & JOURNAL ARTICLES

Dr. Frank’s No-Aging Diet: Eat and Grow Younger. Dial Press, 1976.

Nucleic Acid Nutrition and Therapy. Rainstone Publishing, 1977

Nucleic Acid and Anti Oxidant Therapy of Aging and Degeneration. Royal Health Books, 1977.

Nucleic Acid Therapy in Aging and Degenerative Disease–A Metabolic Approach with DNA, RNA, and Related Metabolites. Psychological Library, 1968.

The Problem of Age, Growth and Death. C.S. Minot. Putnam’s Sons, 1908.

“On the influence of nucleic acids of various origin upon the growth and longevity of the white mouse. ” T. Brailsford Robertson. Australian J. Exp Biol Med Sci, 1928, 5: 47–67.

“The effect of yeast nucleic acid on the survival time of 600 day old albino mice.” Thomas Gardner. J Gerontol, 1946, 1: 445–456

“Prolongation of the life span in rats.” Max Odens. J. American Geriatrics Soc., 1973, XXI: 450–451.

INTERVIEWS

Interview with Dr. Hank Liers, Part 1: Nutritional supplements and cellular energy

Interview with Dr. Hank Liers Part 2: High-RNA superfoods

Interview with Dr. Hank Liers Part 3: Chemical sensitivities and chlorella detoxification

Interview with Dr. Hank Liers Part 4: Reversing mass chemical contamination

Interview with Dr. Hank Liers Part 5: Superior nutrition for pet health

PRODUCTS

Rejuvenate! Berries & Herbs

Rejuvenate!™ PLUS

Rejuvenate!™ (Original)

Rejuvenate! Superfoods: Side-by-Side Comparison

Ultimate Protector™ Nrf2 Activator

HPDI FOUNDATIONAL SUPPLEMENTS

Contact Us:

You can reach HPDI by calling 1-800-228-4265, email support(at)IntegratedHealth.com, or visit the retail website: www.IntegratedHealth.com

Health care professionals and retailers can apply for wholesale account, which includes access to the HPDI reseller website: www.HealthProductsDistributors.com

2

HYDROGEN FOR OPTIMAL HEALTH

Fred Liers PhD molecular hydrogen H2In recent months, I researched and sampled different hydrogen products, including molecular hydrogen and anionic hydrogen products. I posted an article titled Wonders of Molecular Hydrogen last month.

This month I continue writing about benefits of hydrogen for health. Yet, in today’s post I document my personal experience with it, as well as the experiences of a few other individuals who have benefitted from it.

For those who don’t know—and that included me not long ago—hydrogen is the subject of more than 500 peer-reviewed papers in the scientific literature. Hydrogen is rapidly becoming recognized as an important nutrient for health.

According the Molecular Hydrogen Foundation, studies show hydrogen to exhibit therapeutic potential in nearly every organ of the human body, and in 150 different human disease models.

As such, there is an explosion in the amount of research on hydrogen, and quantum leaps are being made in understanding its importance for health.

MY EXPERIENCE WITH HYDROGEN PRODUCTS

I began testing hydrogen products a few months ago. I began by drinking a pre-bottled hydrogen beverage known as H2Bev. Shortly thereafter, I sampled a tablet form that effervesces (fizzes) in water called Active H2.

MegaHydrate Active H2 molecular hydrogen

MegaHydrate and Active H2 are two products providing hydrogen I tested.

Since then I have tried other delivery methods, including a unique encapsulated product known as MegaHydrate, which provides hydrogen anions. I experience benefits from all of them. HPDI now carries all three products.

Here are benefits I notice after using all three products providing hydrogen:

• Greater Physical and Mental Energy. The first benefit I noticed was a increased physical energy closely followed by greater mental energy. This helps me throughout my day, especially in the later afternoons. If I experience a lull in energy, I can take an Active H2 tablet in water or a MegaHydrate and feel an immediate lift.

• Faster Recovery after Exercise. I frequently hike, as well as participate in aikido, yoga, and sometimes run. In each case, I notice decreased recovery times.

• Increased Clarity and Focus. This benefit perhaps relates to increased mental energy. However, beyond mental every itself, I experience clearer thinking and a better ability to focus.

• Less Need for Sleep. I can fall asleep later or wake earlier, with less tiredness during the day. I am not prevented from sleeping. I can just get by with less when necessary, it seems.

• Improved Mood. Maybe this benefit relates to increased physical and/or mental energy. However, for me it means going through the day on an even keel. My mood is pretty good to begin with. I feel this benefit could relate to general feeling of well being I seem to gain when using the hydrogen products.

I experienced these benefits immediately after I began consuming hydrogen-infused water and the MegaHydrate (capsules). I continue seeing these benefits as I have keep taking hydrogen, and have increase my intake. In fact, it feels as if these benefits may accrue over time, so I will continue taking hydrogen over the course of weeks and months ahead.

OTHERS’ EXPERIENCE WITH HYDROGEN

Besides myself, I recently spoke to a few friends and family members, some of whom I gave samples of hydrogen products to try. Here are benefits they report:

• Increased Energy

Nearly everyone I speak to reports increased energy. This may be among the most important benefits because not only because we can all use greater energy, but also because it shows how rapidly and effectively hydrogen works in the body.

• Easier Breathing

Almost everyone who I spoke to who has tried one or more hydrogen products say they breathe easier because of it. One person said it really helped their exercise performance. Another person said that since allergy season has started, this benefit is major for them because usually early spring is a time of difficult breathing for them due to the prevalence of pollens and other plant allergens.

• Sounder Sleep

I personally have noticed I need less sleep. However, others report to me they sleep more soundly. It may be that improved breathing is the reason for sounder sleep. But it may also be they are simply sleeping more soundly as a result of taking the hydrogen. In either case, they enjoy sleeping more soundly.

H2Bev molecular hydrogen H2 product bottle

H2Bev hydrogen-enriched water is pre-bottled, ready to drink.

I WILL ALWAYS TAKE HYDROGEN

Now that I’m testing three hydrogen products and receiving their benefits, I don’t want to be without them. Who wouldn’t want increased physical energy or mental energy or improved breathing? And as much as I gain from a full night’s sleep, the benefit of being able to get by with a little less when necessary is nice.

I have noticed a few other benefits:

• The need for less nutritional supplementation. I will always take nutritional supplements, but I have reduced the amounts I take of certain supplements. This may be due to increased absorption relating to the hydrogen.

• Eating less. I am not sure whether this directly relates to consuming hydrogen. It may be more related to how the body assimilates nutrients when hydrogen is present in my body. In any event, I am eating less and I am less hungry. I’m not depriving myself, I just feel more satisfied from the foods I eat. I have also heard this from others using hydrogen. I’m not sure whether they consider it a benefit or a side-effect. For now, I’m just making observations.

WHAT HYDROGEN PRODUCTS DO I LIKE BEST?

It’s difficult to say which of the three products I’ve tested that I like best. Each appears to have its place in my life.

I enjoy the convenience of H2 Bev when I’m traveling or even just taking a day trip. I can grab a bottle or two and go. I don’t have to worry about mixing tablets with water or taking an extra container with me, or remember to take a capsule.

Active H2 is great, too. It only takes a few minutes for the tablets to fizz. I use a glass or metal container. I would say that ounce-for-ounce Active H2 provides more hydrogen than H2Bev, so this is an advantage to me. Both of these products ensure hydration because you’re drinking water infused with hydrogen.

Megahydrate is the easiest to take due to its capsule form. I feel it offers more noticeable effects (and maybe 2–3 times as much hydrogen per dose as other products) and they last a long time. I don’t necessarily drink much water when taking Megahydrate, but it helps when I do. I need to remember to drink it with sufficient water, perhaps six to twelve ounces.

I really like Megahydrate, and it offers certain advantages. It has broad applicability like other hydrogen products. But it is unique because it has different modes of action containing an abundance of negative hydrogen ions within a colloidal silica matrix.

In fact, Megahydrate may be the ultimate hydrogen product (even better than molecular hydrogen). This is because it not only greatly enhances the production of ATP (cellular energy) in the body and the hydrogen it provides acts as a powerful antioxidant, but also because it can unlock the potential of water as a medium for nutrient replenishment and waste removal at the cellular level. This makes it a uniquely different product.

SUMMARY

Hydrogen is a worthy supplement with much scientific literature behind it. The fact that I receive similar benefits from three different products speaks well for the science. Regardless of which hydrogen products I use on a given day, what I gain from them is what matters most.

I will continue testing products providing hydrogen. I will write additional blog articles and perhaps update this post, as well. I recommend individuals try molecular hydrogen products for themselves because I believe most people will benefit significantly from them.

We also recommend checking out the website of the Molecular Hydrogen Foundation (www.molecularhydrogenfoundation.org), which provides scientific studies and technical information about hydrogen.

ADDITIONAL RESOURCES

Molecular Hydrogen Foundation (MHF)

Wonders of Molecular Hydrogen
by Fred Liers, PhD (from the HPDI blog)

Molecular Hydrogen (H2) at the Forefront of Health Research
by Hank Liers, PhD (from the HPDI blog)

ACTIVE H2 (tablet)

H2BEV (bottle)

MegaHydrate™ (capsule)

Contact Us:

You can reach HPDI by calling 1-800-228-4265, email support(at)IntegratedHealth.com, or visit the retail website: www.IntegratedHealth.com

Health care professionals and retailers can apply for wholesale account, which includes access to the HPDI reseller website: www.HealthProductsDistributors.com

0

WONDERS OF MOLECULAR HYDROGEN

Fred Liers PhD molecular hydrogen H2I drink hydrogen-infused water. You should, too. Why? Because the age of hydrogen is here. Molecular hydrogen, that is. We now know that molecular hydrogen has therapeutic potential for nearly every organ in the human body, as well as for 150 different human disease models! And it’s extremely safe.

MOLECULAR HYDROGEN: BACKGROUND

Molecular hydrogen, also known as “diatomic hydrogen,” is a colorless, tasteless, and odorless gas.

Elemental hydrogen (H) is the most abundant element in the universe constituting 75% of its mass. Yet, it is absent on earth in its monoatomic form, being present in water, and inorganic and organic compounds. Molecular hydrogen is found in the earth’s atmosphere at less than one part per million.

molecular hydrogen H2 water

Hydrogen-infused water is a simple means to consume molecular hydrogen.

The science regarding benefits to health of molecular hydrogen (H2) has advanced rapidly in recent years thanks to the pioneering efforts of research scientists around the globe.

Now hydrogen science is moving quickly beyond theory to practical applications. Moreover, new products exist allowing medical professionals and consumers to leverage the health benefits of hydrogen.

For decades, diatomic molecular hydrogen was generally considered an “inert” gas. That is perhaps the primary reason that molecular hydrogen has been recognized as a therapeutic molecule only recently.

Indeed, science has known about the health benefits of molecular hydrogen as early as 1798. Yet, as noted, for most of modern history the belief persisted that hydrogen was inert in the body. It was only in the late 20th century (ca. 1975) that it gained the attention of medical researchers, and only in the past 10 years has evidence for the health effects of molecular hydrogen gained critical mass in the scientific literature.

There are now more than 500 peer-reviewed articles demonstrating the therapeutic potential of hydrogen for nearly every organ in the human body, as well as in 150 different human disease models, according to the Molecular Hydrogen Foundation.

HEALTH BENEFITS OF MOLECULAR HYDROGEN (H2)

• Molecular hydrogen reduces oxidative stress as a selective antioxidant and by maintaining homeostatic levels of glutathione, superoxide dismutase, catalase,  and other free-radical scavenging nutrients.

• The antioxidant capacities of molecular hydrogen are such that it is beneficial for persistent and acute oxidative stress.

• Acute oxidative stress arises from a multitude of causes, including inflammation, cardiac or cerebral infarction, organ transplantation, heavy exercise, cessation of operative bleeding, and many other causes.

• Persistent oxidative stress relates to reactive oxygen species (ROS) generated in the body throughout life. For example, during exercise, exposure to pollutants and toxins or UV light, as well as physical and psychological stresses, and the aging process itself. As aerobic organisms, we generate ROS when breathing consumes oxygen.

• Molecular hydrogen is effective against hydroxyl radicals (OH). The hydroxyl radical is the radical species that causes much of the oxidative damage in the body. While vitamin C, glutathione, and certain plant-based antioxidants are somewhat effective against this radical, there is no Nrf2-induced enzyme that effectively quenches the hydroxl radical.

• This positions molecular hydrogen as a uniquely effective antioxidant against the hydroxyl radical. Notably, when molecular hydrogen quenches the hydroxyl radical, it produces water, which is non-toxic in the body.

• Beyond this, molecular hydrogen, like other gaseous signaling molecules such as NO, CO, H2S, appears to exhibit cell signal-modulating activity that confers it with anti-inflammatory, anti-obesity, anti-allergy, and many other benefits.

MOLECULAR HYDROGEN MEDICINE

The scientific literature discusses the use of molecular hydrogen for many clinical applications, including the following:

• METABOLIC SYNDROME including diabetes, hyperlipidemia, arteriosclerosis, hypertension, and obesity

• ISCHEMIA / REPERFUSION injuries including cerebral and myocardial infarctions, organ transplants, post-cardiac arrest

• NEUROPROTECTION including applications for dementia, Parkinson’s disease, depression, and anesthesia

• INFLAMMATION including applications for polymicrobial sepsis, rheumatoid arthritis, wound healing, and bowel diseases

• MITOCHONDRIAL DISEASES

• HEMODIALYSIS / VENTILATION

• AGING including cognitive decline

• EXERCISE including applications for fatigue, lactic acid, recovery, and oxidative stress related to heavy exercise

SIDE EFFECTS OF CANCER THERAPIES including radiotherapy and chemotherapy

• MANY OTHER BENEFITS

athlete molecular hydrogen performance race

Athletes benefit from molecular hydrogen. You can, too.

HOW MOLECULAR HYDROGEN WORKS

According to the Molecular Hydrogen Foundation, there are three ways molecular hydrogen exerts positive health effects.

1.  Molecular hydrogen easily diffuses into subcellular compartments where it scavenges cytotoxic oxygen radicals, thereby protecting DNA, RNA, and proteins against oxidative stress.

2.  Molecular hydrogen triggers activation or upregulation of additional antioxidant enzymes (e.g., glutathione, superoxide dismutase, catalase, and others) and/or cytoprotective proteins of the body.

3.  Molecular hydrogen may be a novel signaling molecule that alters cell signaling, cell metabolism, and gene expression. This may explain its apparent anti-inflammatory, anti-allergic, and anti-apoptotic (or anti-cell death) effects.

MOLECULAR HYDROGEN IS SAFE

Molecular hydrogen exhibits great safety, and it is regarded as safe for use in the body. It is shown no toxicity even in high concentrations.

Safety standards are already established for high concentrations of molecular hydrogen for inhalation because high-pressure H2 gas is used in deep-water diving gas mixtures to prevent decompression sickness.

Notably, H2 gas combusts only at temperatures higher than 527 °C, and it explodes by chain reaction with oxygen (O2) only in the range of Hconcentration (4–75%, vol/vol).

Molecular hydrogen can be used for medical applications safely by several ingestion methods including inhalation of 1–4% hydrogen gas, which exhibits great effectiveness.

All these factors mean that molecular hydrogen is safe, easy-to-use, and effective for therapeutic purposes.

molecular hydrogen H2 water

Hydrogen-infused water is safe, easy-to-consume, and cost effective.

USING MOLECULAR HYDROGEN

Methods for consuming molecular hydrogen include inhalation, oral ingestion of hydrogen-infused water, injection of hydrogen saline, and direct diffusion (eye drops, baths, cosmetics, etc.).

An advantage of inhaled H2 gas is that is acts rapidly. In this respect, may be suitable for defense against acute oxidative stress.

It has been shown that inhalation of 3–4% hydrogen (H2) gas reaches a plateau at approximately 10–20 μM in the arterial and venous blood in about 20 minutes. This is shown not to affect any physiological parameters (e.g., blood pressure), suggesting no adverse effects.

According to the Molecular Hydrogen Foundation, the consensus is that drinking H2-rich water is the easiest, and often the most effective, method for obtaining molecular hydrogen although it does not provide as many hydrogen molecules to the body as other methods.

Some studies show consuming H2-infused water to be more effective than inhalation or increasing intestinal H2 production via lactulose administration.

Another advantage of drinking hydrogen infused water is that it allows gastric induction of ghrelin, which is mediated via activation of beta 1 adrenergic receptors.

Above all, drinking hydrogen-infused water is easy to do, and convenient as you can drink it at home or while traveling.

HYDROGEN-INFUSED WATER

Inhalation of molecular hydrogen gas may be impractical for continuous H2 consumption in daily life. In contrast, solubilized H2 (hydrogen-infused water) is a portable, easily administered, and safe means to ingest H2.

H2 can be dissolved in water up to 0.8 mM (1.6 mg/L) under atmospheric pressure at room temperature without changing pH.

Hwater can be made by several methods: infusing H2 gas into water under pressure, electrolyzing water to producing H2, and reacting magnesium metal or its hydride with water.

Notably, H2 penetrates glass or plastic walls of vessels in a short time, yet aluminum containers retain hydrogen gas for a long time.

Water ionizers produce hydrogen gas via electrolysis. This method produces hydrogen concentrations from less than 0.05 ppm to more than 2.5 ppm. Typically 0.1 to 0.7 ppm hydrogen is produced, yet most companies manufacturing water ionizers neither know the concentration produced nor understand the significance of hydrogen for health.

In this regard, depending upon the production method much of the water containing molecular hydrogen exhibits a negative oxygen reduction potential (ORP). Yet, ORP is only a general indication of hydrogen production and is not a measurement of its concentration.

A second method of producing hydrogen-rich water by electrolysis is by infusion. In this method, hydrogen is directly infused into filtered water within a machine.

Another convenient method to generate molecular hydrogen is to add alkali-earth metals to water. Magnesium metal in commonly used for this purpose. This method allows for the production of high concentrations of molecular hydrogen that are generally near saturation (1.6 ppm), and therefore less water needs to be consumed by individuals drinking it.

Magnesium sticks and tablets/capsules are available (some of which are placed in water and others that can be consumed directly) that rapidly produce 2–4 ppm molecular hydrogen concentration. Like electrolysis, adding metals to water also increased the pH of water because they reduce the concentration of H+ ions.

Other methods exist that can produce supersaturated concentrations of molecular hydrogen with or without alteration of water pH. Advantages of these methods include having to drink a fraction of the amount of water in order to obtain an equal amount of molecular hydrogen.

Drinking water containing molecular hydrogen is probably the easiest and most cost-effective means for most persons to obtain hydrogen.

man drinks water infused with molecular hydrogen

Hydrogen-infused water can be consumed using tablets, prepared H2 beverages, or ionized water.

MOLECULAR HYDROGEN FROM YOUR MICROBIOME

Certain types bacteria in the intestinal tract produce hydrogen gas from non-digestible fibers, which may explain how fiber-rich diets reduce inflammation, and exert cardiovascular and other health benefits.

Diets low in dietary fiber from fruits and vegetables, or a decrease in microbiome diversity could potentially reduce production of molecular hydrogen. This could exert adverse effects on health.

The presence (or absence) of a diverse and robust microbiome may be one of the most significant factors in terms of how much hydrogen can be generated in the body. Most people today do not create the levels of molecular hydrogen in their digestive tracts that humans in earlier time periods generated largely because due to modern diets and less than optimal microbiome health.

Factors that influence or reduce microbiome health and diversity include antibiotic use, imbalanced diet, lack of certain fiber-rich vegetables in the diet, and consumption of herbicides, pesticides, and GMOs (that include glyphosate) that harm microbial populations and cause “leaky gut”.

As knowledge increases regarding ways we can support a healthy microbiome, the biological significance of hydrogen historically produced in our digestive tracts will be better understood.

BENEFIT TODAY FROM MOLECULAR HYDROGEN

The clinical applications of molecular hydrogen are impressive. One of the great advantages of molecular hydrogen infused water is that  it is easy to consume it, or make it in your own home or wherever you happen to be.

HPDI now sells a tablet hydrogen product from Purative known as Active H2.

Active H2 is a unique, patent-pending combination of all-natural minerals used to generate molecular hydrogen and electron-rich potential (-ORP). This distinguishes it from existing hydrogen formulas and electrolysis (water ionizers).

Active H2 is easy to use.  Simply place one tablet of in a 1/2 liter (16 oz) container of pure water (filled to the top) and close tightly. Wait at least 5–10 minutes for it to completely disintegrate (fizz), and then drink.

A one pint glass mason jar works well as a container for this purpose. However, you can use up to one liter (about 32 ounces) of water in a container, so a quart mason jar also works well. Consume the hydrogen-infused water ideally at least 30 minutes before food.

Active H2 formula consists of a proprietary blend of pure magnesium, malic acid, fumaric acid, and maltose that synergistically act to generate molecular hydrogen and electron-rich potential (-ORP).

Active H2 is the only all-natural add-in tablet providing molecular hydrogen in the amount of greater than 1.8 ppm, That is, one tablet typically generates molecular hydrogen in the concentration of about 2 ppm.

There are other molecular hydrogen products, including tablets, sticks, and pre-infused bottled products like H2Bev. H2Bev provides about 1.2–1.5 ppm of molecular hydrogen and comes in a 12 oz coated aluminum container for excellent H2 retention.

MOLECULAR HYDROGEN SUMMARY

Molecular hydrogen sits in the unique position of providing significant, wide-ranging benefits for health with an unmatched ease-of-use, and at relatively low cost for what it delivers.

We highly recommend the use of molecular hydrogen for its health benefits and for therapeutic applications. This includes the consumption of hydrogen-infused water whether from prepared H2 beverages, water ionizers, or highly effective Active H2 tablets.

Below we include important scientific abstracts you may find helpful in understanding the benefits and applications of molecular hydrogen.

 

SCIENTIFIC STUDIES ON MOLECULAR HYDROGEN

Beneficial biological effects and the underlying mechanisms of molecular hydrogen – comprehensive review of 321 original articles

From: http://www.ncbi.nlm.nih.gov/pubmed/26483953

Abstract
Therapeutic effects of molecular hydrogen for a wide range of disease models and human diseases have been investigated since 2007. A total of 321 original articles have been published from 2007 to June 2015. Most studies have been conducted in Japan, China, and the USA. About three-quarters of the articles show the effects in mice and rats. The number of clinical trials is increasing every year. In most diseases, the effect of hydrogen has been reported with hydrogen water or hydrogen gas, which was followed by confirmation of the effect with hydrogen-rich saline. Hydrogen water is mostly given ad libitum. Hydrogen gas of less than 4% is given by inhalation. The effects have been reported in essentially all organs covering 31 disease categories that can be subdivided into 166 disease models, human diseases, treatment-associated pathologies, and pathophysiological conditions of plants with a predominance of oxidative stress-mediated diseases and inflammatory diseases. Specific extinctions of hydroxyl radical and peroxynitrite were initially presented, but the radical-scavenging effect of hydrogen cannot be held solely accountable for its drastic effects. We and others have shown that the effects can be mediated by modulating activities and expressions of various molecules such as Lyn, ERK, p38, JNK, ASK1, Akt, GTP-Rac1, iNOS, Nox1, NF-κB p65, IκBα, STAT3, NFATc1, c-Fos, and ghrelin. Master regulator(s) that drive these modifications, however, remain to be elucidated and are currently being extensively investigated.

Molecular hydrogen as a preventive and therapeutic medical gas: initiation, development and potential of hydrogen medicine

From: http://www.ncbi.nlm.nih.gov/pubmed/24769081

Abstract
Molecular hydrogen (H2) has been accepted to be an inert and nonfunctional molecule in our body. We have turned this concept by demonstrating that H2 reacts with strong oxidants such as hydroxyl radical in cells, and proposed its potential for preventive and therapeutic applications. H2 has a number of advantages exhibiting extensive effects: H2 rapidly diffuses into tissues and cells, and it is mild enough neither to disturb metabolic redox reactions nor to affect signaling reactive oxygen species; therefore, there should be no or little adverse effects of H2. There are several methods to ingest or consume H2; inhaling H2 gas, drinking H2-dissolved water (H2-water), injecting H2-dissolved saline (H2-saline), taking an H2 bath, or dropping H2-saline into the eyes. The numerous publications on its biological and medical benefits revealed that H2 reduces oxidative stress not only by direct reactions with strong oxidants, but also indirectly by regulating various gene expressions. Moreover, by regulating the gene expressions, H2 functions as an anti-inflammatory and anti-apoptotic, and stimulates energy metabolism. In addition to growing evidence obtained by model animal experiments, extensive clinical examinations were performed or are under investigation. Since most drugs specifically act to their targets, H2 seems to differ from conventional pharmaceutical drugs. Owing to its great efficacy and lack of adverse effects, H2 has promising potential for clinical use against many diseases.

Molecular hydrogen in drinking water protects against neurodegenerative changes induced by traumatic brain injury.

From: http://www.ncbi.nlm.nih.gov/pubmed/25251220

Abstract
Traumatic brain injury (TBI) in its various forms has emerged as a major problem for modern society. Acute TBI can transform into a chronic condition and be a risk factor for neurodegenerative diseases such as Alzheimer’s and Parkinson’s diseases, probably through induction of oxidative stress and neuroinflammation. Here, we examined the ability of the antioxidant molecular hydrogen given in drinking water (molecular hydrogen water; mHW) to alter the acute changes induced by controlled cortical impact (CCI), a commonly used experimental model of TBI. We found that mHW reversed CCI-induced edema by about half, completely blocked pathological tau expression, accentuated an early increase seen in several cytokines but attenuated that increase by day 7, reversed changes seen in the protein levels of aquaporin-4, HIF-1, MMP-2, and MMP-9, but not for amyloid beta peptide 1-40 or 1-42. Treatment with mHW also reversed the increase seen 4 h after CCI in gene expression related to oxidation/carbohydrate metabolism, cytokine release, leukocyte or cell migration, cytokine transport, ATP and nucleotide binding. Finally, we found that mHW preserved or increased ATP levels and propose a new mechanism for mHW, that of ATP production through the Jagendorf reaction. These results show that molecular hydrogen given in drinking water reverses many of the sequelae of CCI and suggests that it could be an easily administered, highly effective treatment for TBI.

The evolution of molecular hydrogen: a noteworthy potential therapy with clinical significance

From: http://www.ncbi.nlm.nih.gov/pubmed/23680032

Abstract
Studies on molecular hydrogen have evolved tremendously from its humble beginnings and have continued to change throughout the years. Hydrogen is extremely unique since it has the capability to act at the cellular level. Hydrogen is qualified to cross the blood brain barrier, to enter the mitochondria, and even has the ability to translocate to the nucleus under certain conditions. Once in these ideal locations of the cell, previous studies have shown that hydrogen exerts antioxidant, anti-apoptotic, anti-inflammatory, and cytoprotective properties that are beneficial to the cell. Hydrogen is most commonly applied as a gas, water, saline, and can be applied in a variety of other mediums. There are also few side effects involving hydrogen, thus making hydrogen a perfect medical gas candidate for the convention of novel therapeutic strategies against cardiovascular, cerebrovascular, cancer, metabolic, and respiratory diseases and disorders. Although hydrogen appears to be faultless at times, there still are several deficiencies or snares that need to be investigated by future studies. This review article seeks to delve and comprehensively analyze the research and experiments that alludes to molecular hydrogen being a novel therapeutic treatment that medicine desperately needs.

Molecular hydrogen as an emerging therapeutic medical gas for neurodegenerative and other diseases

From: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377272/

Abstract
Effects of molecular hydrogen on various diseases have been documented for 63 disease models and human diseases in the past four and a half years. Most studies have been performed on rodents including two models of Parkinson’s disease and three models of Alzheimer’s disease. Prominent effects are observed especially in oxidative stress-mediated diseases including neonatal cerebral hypoxia; Parkinson’s disease; ischemia/reperfusion of spinal cord, heart, lung, liver, kidney, and intestine; transplantation of lung, heart, kidney, and intestine. Six human diseases have been studied to date: diabetes mellitus type 2, metabolic syndrome, hemodialysis, inflammatory and mitochondrial myopathies, brain stem infarction, and radiation-induced adverse effects. Two enigmas, however, remain to be solved. First, no dose-response effect is observed. Rodents and humans are able to take a small amount of hydrogen by drinking hydrogen-rich water, but marked effects are observed. Second, intestinal bacteria in humans and rodents produce a large amount of hydrogen, but an addition of a small amount of hydrogen exhibits marked effects. Further studies are required to elucidate molecular bases of prominent hydrogen effects and to determine the optimal frequency, amount, and method of hydrogen administration for each human disease.

Molecular hydrogen is a novel antioxidant to efficiently reduce oxidative stress with potential for the improvement of mitochondrial diseases

From: http://www.ncbi.nlm.nih.gov/pubmed/21621588

Abstract

BACKGROUND:
Mitochondria are the major source of oxidative stress. Acute oxidative stress causes serious damage to tissues, and persistent oxidative stress is one of the causes of many common diseases, cancer and the aging process; however, there has been little success in developing an effective antioxidant with no side effect. We have reported that molecular hydrogen has potential as an effective antioxidant for medical applications [Ohsawa et al., Nat. Med. 13 (2007) 688-694].

SCOPE OF REVIEW:
We review the recent progress toward therapeutic and preventive applications of hydrogen. Since we published the first paper in Nature Medicine, effects of hydrogen have been reported in more than 38 diseases, physiological states and clinical tests in leading biological/medical journals. Based on this cumulative knowledge, the beneficial biological effects of hydrogen have been confirmed. There are several ways to intake or consume hydrogen, including inhaling hydrogen gas, drinking hydrogen-dissolved water, taking a hydrogen bath, injecting hydrogen-dissolved saline, dropping hydrogen-dissolved saline into the eyes, and increasing the production of intestinal hydrogen by bacteria. Hydrogen has many advantages for therapeutic and preventive applications, and shows not only anti-oxidative stress effects, but also has various anti-inflammatory and anti-allergic effects. Preliminary clinical trials show that drinking hydrogen-dissolved water seems to improve the pathology of mitochondrial disorders.

MAJOR CONCLUSIONS:
Hydrogen has biological benefits toward preventive and therapeutic applications; however, the molecular mechanisms underlying the marked effects of small amounts of hydrogen remain elusive.

GENERAL SIGNIFICANCE:
Hydrogen is a novel antioxidant with great potential for actual medical applications. This article is part of a Special Issue entitled Biochemistry of Mitochondria.

Recent progress toward hydrogen medicine: potential of molecular hydrogen for preventive and therapeutic applications

From: http://www.ncbi.nlm.nih.gov/pubmed/21736547

Abstract
Persistent oxidative stress is one of the major causes of most lifestyle-related diseases, cancer and the aging process. Acute oxidative stress directly causes serious damage to tissues. Despite the clinical importance of oxidative damage, antioxidants have been of limited therapeutic success. We have proposed that molecular hydrogen (H(2)) has potential as a “novel” antioxidant in preventive and therapeutic applications [Ohsawa et al., Nat Med. 2007: 13; 688-94]. H(2) has a number of advantages as a potential antioxidant: H(2) rapidly diffuses into tissues and cells, and it is mild enough neither to disturb metabolic redox reactions nor to affect reactive oxygen species (ROS) that function in cell signaling, thereby, there should be little adverse effects of consuming H(2). There are several methods to ingest or consume H(2), including inhaling hydrogen gas, drinking H(2)-dissolved water (hydrogen water), taking a hydrogen bath, injecting H(2)- dissolved saline (hydrogen saline), dropping hydrogen saline onto the eye, and increasing the production of intestinal H(2) by bacteria. Since the publication of the first H(2) paper in Nature Medicine in 2007, the biological effects of H(2) have been confirmed by the publication of more than 38 diseases, physiological states and clinical tests in leading biological/medical journals, and several groups have started clinical examinations. Moreover, H(2) shows not only effects against oxidative stress, but also various anti-inflammatory and antiallergic effects. H(2) regulates various gene expressions and protein-phosphorylations, though the molecular mechanisms underlying the marked effects of very small amounts of H(2) remain elusive.

Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals

From: http://www.ncbi.nlm.nih.gov/pubmed/17486089

Abstract
Acute oxidative stress induced by ischemia-reperfusion or inflammation causes serious damage to tissues, and persistent oxidative stress is accepted as one of the causes of many common diseases including cancer. We show here that hydrogen (H(2)) has potential as an antioxidant in preventive and therapeutic applications. We induced acute oxidative stress in cultured cells by three independent methods. H(2) selectively reduced the hydroxyl radical, the most cytotoxic of reactive oxygen species (ROS), and effectively protected cells; however, H(2) did not react with other ROS, which possess physiological roles. We used an acute rat model in which oxidative stress damage was induced in the brain by focal ischemia and reperfusion. The inhalation of H(2) gas markedly suppressed brain injury by buffering the effects of oxidative stress. Thus H(2) can be used as an effective antioxidant therapy; owing to its ability to rapidly diffuse across membranes, it can reach and react with cytotoxic ROS and thus protect against oxidative damage.

ADDITIONAL RESOURCES

MOLECULAR HYDROGEN (H2) AT FOREFRONT OF HEALTH RESEARCH
by Hank Liers, PhD (from the HPDI blog)

ACTIVE H2 (tablet product)

Molecular Hydrogen Foundation (MHF)

Contact Us:

You can reach HPDI by calling 1-800-228-4265, email support(at)IntegratedHealth.com, or visit the retail website: www.IntegratedHealth.com

Health care professionals and retailers can apply for wholesale account, which includes access to the HPDI reseller website: www.HealthProductsDistributors.com

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Microbiome, Diet, and Prescript-Assist Probiotic & Prebiotic

Fred Liers PhD microbiome health probiotics prebioticsGut health is paramount to overall health. This was known in ancient times. According to the 4th-century (BCE) Greek physician Hippocrates, “All disease begins in the gut.” And since our founding in 1988, we at Health Products Distributors, Inc. (HPDI) have recognized the importance of supporting a healthy microbiome through diet, lifestyle, and the use of probiotic supplements.

We have written blog articles on developments regarding the microbiome, including “The Advantages of Soil Based Organisms for Health” (2014) and Dr. Hank’s short piece “A New View of the Role of Bacteria for Health” (2012).

However, the scientific understanding of the microbiome continues making quantum leaps. Every month it seems there is another groundbreaking study reported, or fresh information about the human microbiome highlighting specific aspects of its fundamental role in human health.

Gut health is paramount for good health.

Gut health is paramount for good health.

For example, studies showing the microbiome’s significance for brain function, digestive tract health, leaky gut, immune system function, and lifelong health. And even more, studies revealing potential connections between microbiome status and conditions involving the gut-brain axis, such as gluten sensitivity, celiac disease, ADHD, autism, depression, Parkinson’s disease, and Alzheimer’s disease.

As exciting as the studies are on a theoretical level, one of the main benefits is that many of them point to practical applications and suggestions that can be implemented on a daily basis by individuals wishing to improve microbiome health and vitality.

Information about means you can take to improve microbiome health is increasingly available not only in the scientific literature (which can be searched for in places like PubMed), but also in the popular media. For example, books like Dr. David Perlmutter’s Brain Maker: The Power of Gut Microbes to Heal and Protect Your Brain for Life (2015) include dietary recommendations and recipes. In addition, there are numerous books and online resources for making your own cultured foods (everything from kombucha tea to fermented condiments), as I will talk about more below.

sauerkraut kimchi yogurt probiotic fermented food microbiome

Fermented foods like sauerkraut, kimchi and yogurt provide beneficial bacteria.

Increasingly, individuals are speaking with their nutritionist or doctor on this topic, as knowledge of the important role of foods and nutrition in supporting a healthy microbiome.

While at the ACAM (American College for Advancement in Medicine) annual meeting in Las Vegas in November, I attended a presentation by Raphael Kellman, MD. He discussed the importance of the microbiome for supporting health, and the positive effects related to maintaining populations of beneficial flora, including the fact that probiotics can support positive emotions.

I present a few recommendations for supporting and improving microbiome health through lifestyle, dietary choices, and the use of probiotic supplements.

DIETARY RECOMMENDATIONS FOR MICROBIOME HEALTH

Dietary choices are among the simplest, yet most effective means for effecting improvement  in the human microbiome. Here are some dietary recommendations that are known to work.

Consume Foods High in Probiotics, including Fermented Foods. Foods high in probiotics include yogurt, kefir, sauerkraut, kim chee, tempeh, pickles and other pickled vegetables, and kombucha tea.

Probiotic foods provide you directly with good-for-you bacteria that help keep your microbiome diverse and well balanced.

Historically, many of the most important bacteria for gut health are lactobacteria and bifidobacteria. Some of the most well-recognized strains of these types include L. acidophilus, B. longum, B. bifidum, L. fermentum, and L. rhamnosus.

Notably, studies indicate reduced levels of lactobacteria and bifidobacteria in depressed individuals. While these two types of bacteria are perhaps the most studied and well-known, there are hundreds or thousands of different types of beneficial bacteria in the human microbiome. I will talk more about some of them when I discuss soil-based organisms.

Source probiotic foods that are organic, biodynamic, garden grown, and free-range / pasture-raised (e.g., dairy products). For pickles and relishes should preferably be unpasteurized and fermented in brine.

Consume Prebiotic Foods. It is important to consume foods that provide non-digestible short-chain fatty acids (SCFA) that support a flourishing good-for-you microbial community. Prebiotic foods include onions, garlic, asparagus, radishes, beans, oats.

Many prebiotic foods contain relatively high amounts of inulin, which is a soluble dietary fiber and a naturally occurring oligosaccharide. Inulin belongs to a class of carbohydrates called fructans.

Inulin selectively feeds beneficial bacteria. Major inulin-containing foods include Jersusalem artichoke (sunchokes), bananas, leeks, beets, and certain herbs. Chicory root, elecampane root, and dandelion root are especially high in inulin.

The fermentation of indigestible complex carbohydrates like inulin (and other natural dietary fibers) in the digestive tract results in the production of short-chain fatty acids that feed beneficial microbiota.

asparagus prebiotic microbiome beneficial bacteria

Asparagus contains the prebiotic inulin.

The three primary short chain fatty acids created by gut bacteria are acetic, butryic, and propionic acids. These fatty acids are excreted or absorbed by the colon and used for energy by cells. For example, butyric acid provides fuel for cells lining the colon and is associated with positive benefits.

Because different bacterial species produce different fatty acids, the ratio of the different species is important for health. In particular, butyric acid is associated with positive health benefits.

In contrast, clostridial species produce proprionic acid (PPA), which is too high quantities is known to exert adverse effects in the body, including the brain. Interestingly, studies show that autistic individuals harbor more clostridial species some of which are remarkably absent in normal populations.

At least one comparative study showed the the microbiomes of urban, Western populations (consuming more refined foods) produce relatively high levels of proprionic acid whereas the microbiomes found in rural, non-western populations (consuming more dietary fiber) produce more butyric acid.

Other studies indicate that the microbiome of rural populations predominantly contains bacteroides type flora (associated with lean body mass) and urban populations contain primarily firmicutes (associated with obesity when predominant).

Consume vegetables, including leafy green vegetables: Diets that include relatively high amounts of greens are beneficial for feeding a diverse and healthy microbial community. This is not only because of high-nutrient density and dietary fiber, but also due to the beneficial bacteria naturally present in these foods.

Reduce intake of sugars, especially refined sugars and high-fructose corn syrup. Natural sugars in fruits and vegetables are generally better to consume because they are ingested along with dietary fiber as part of the whole food. Refined sugars and especially high-fructose corn syrup (HFCS) test the body’s capacity for dealing with sugar, stress the body, prematurely age cells (via glycation processes), and promote adverse changes that can ultimately lead to diabetes.

Avoid foods containing antibiotics. Antibiotics in foods damage the microbiome by killing bacteria (including beneficial bacteria), reducing microbial diversity, and leaving the microbiome vulnerable to hostile takeover. Thus, consume only free-range, antiobiotic-free meats, eggs, and poultry. Avoid factory farmed meats and farmed fish.

Avoid simple carbohydrates. Like refined sugars, refined carbohydrates and grain products are notorious culprits for producing an imbalanced microbiome. So, avoid overconsuming processed grains, especially those containing wheat.

Avoid gluten. Wheat and the gluten it contains has been implicated in adverse conditions for the microbiome. Yet, wheat isn’t the only food containing gluten. While this may sound like advice given only for celiacs or IBS patients, the picture emerging regarding gluten is that it is associated with adverse changes in the microbiome. Similarly, adverse changes in the microbiome are associated with the development of gluten sensitivity and celiac disease.

one hundred percent organic

Organic and biodynamic foods support a healthy microbiome.

Avoid genetically modified foods (GMOs). The consensus is emerging that genetically modified (or genetically engineered) foods contribute to problems in the microbiome. Herbicides used on GMO crops, such as glyphosate, harm the microbiome and contribute to states of depleted nutrition.

Avoid artificial sweeteners. As bad as refined sugars are for the microbiome, artificial sweeteners can be just as bad or worse. Beyond the fact that artificial sweeteners tend to be toxic, they are known to produce adverse changes in the microbiome.

Choose organic, biodynamic, pesticide-free, and garden-raised. Regarding food choices, do your best to obtain naturally grown foods and to avoid agricultural chemicals.

LIFESTYLE CHOICES SUPPORTING THE MICROBIOME

Avoid Antibiotics. Whenever possible, avoid taking antibiotics. These can destroy the balance in your microbiome.

Avoid antimicrobial products. These include soaps (containing triclosan and other chemicals), antimicrobial coatings (like Microban), and antibacterial substances.

Avoid chemicals that affect your microbiome. For example, avoid products and foods with synthetic, toxic preservatives. Drink filtered water (i.e., non-chlorinated water).

Get Dirty. Try gardening, spend time outdoors, or just be in nature more often. Unpolluted soils are an excellent source of natural microbes needed to keep you microbiome in balance.

PROBIOTIC & PREBIOTIC SUPPLEMENTATION

In addition to consuming probiotic and prebiotic foods, it can be helpful to take a probiotic supplement. Many of the probiotic supplements on the market provide a full complement of lactobacteria and/or bifidobacteria (often in the same formula).

It is especially useful to take probiotic supplements after exposure to antibiotics. However, probiotic supplements can offer be an effective adjunct to a probiotic (and prebiotic) friendly diet.

More recently, soil based organisms have garnered attention as important constituents of a healthy microbiome. These differ from lactobacteria, and in many ways are hardier and easier to get into the gut where they can thrive. It is also known that fulvic and humic acids act as prebiotics feeding microbes found in soils (soil based organisms) that support human health.

WHAT ARE SOIL BASED ORGANISMS (SBO)?

There are thousands of different types of bacteria found naturally in soils. These bacteria in soil and dirt historically performed many beneficial functions for us. It appears they help our bodies regulate immunity, and protect us from bacterial and fungal overgrowths in our intestinal tracts.

Up until 100 years ago (or less for some people), soil based organisms were an everyday part of the diet. Not that long ago, our country was comprised mostly of farmers. Agriculture was more about getting dirty than about efficient machinery and chemicals inputs (i.e., industrial agriculture). At that time, almost everyone would have consumed soil based organisms on vegetables and other foods from the fields, gardens, and orchards.

Today due to lack of exposure to soil based organisms resulting from modern food processing systems and the extensive use of pesticides that destroy the organisms, the average person has a very different composition of intestinal flora from their ancestors. There are far fewer soil based organisms, and more lactic acid bacteria. In addition, the use of antibiotics for young children has further swayed the balance away from these beneficial bacteria.

soil based organisms carrots

Healthy soils host soil based organisms. Foods grown traditionally without the use of synthetic herbicides and fertilizer provide high levels of SBOs naturally.

With a dramatic rise in research into the benefits of soil based organisms, new products have been developed that help us reintroduce them into our intestinal tracts. There they offer many benefits, including improving digestion, boosting immunity, and supporting overall good health in the intestines (with such benefits as reduced bloating, flatulence, and constipation).

And for example, certain soil based organisms are known to secrete proteins activating the immune system, as well as stimulating the production of white blood cells and antibodies.

BENEFITS OF SOIL BASED ORGANISMS

Increasing evidence supports the idea that soil based organisms are essential for human health. Here are a few of the reported benefits:

  • Improved Gastrointestinal Health
  • Prevention of Gut Colonization by Harmful Bacteria and Fungi
  • Support for Intestinal Regeneration
  • Support for Balancing Gut Microbiota
  • Help Balance Colon pH
  • Increase Resistance to Harmful Bacteria and Fungi
  • Increase Absorption of Nutrients in the Intestines
  • Help Replenish Friendly Microflora in the Colon
  • Support Overall Health and Well Being
  • Enhance Metabolism in the Gut
  • Promote and Normalize Bowel Function
  • Help Reduce Gas and Bloating
  • Improve Immune System Function
  • Improve GI Tract Barrier Function
  • Many Other Benefits

SOIL BASED ORGANISMS ARE DIFFERENT THAN LACTOBACTERIA

Most people today either take or are aware of the benefits of probiotics containing lactic acid-based bacteria. These include commonly known strains of lactobacilli and bifidobacteria. Lactic-acid bacteria certainly are beneficial. There is a large body of research showing their high value for supporting digestion, immunity, and many other benefits. But they do have certain limitations.

Many of the lactic acid bacteria in probiotic formulas have difficulty making it through the stomach’s acidic environment. Thus, the bacteria arrive in the small intestine in vastly reduced numbers compared to the amount that must be consumed. Nutritionists therefore usually recommend taking probiotics with a large number of “colony forming units” (CFU) in order to ensure viability of the bacteria.

In addition, the benefits conferred by taking lactic acid bacteria may depend upon continuing usage. That is, certain studies indicate the benefits of these bacteria are greatly reduced after usage ends.

Soil based organisms offer several advantages compared to lactic-acid bacteria. First, they are extremely hardy and better able to withstand the acidic environment in the stomach. They are in fact, “endospore-forming” bacteria that surround themselves in a hard exterior that travels more effectively through the intestinal tract.

This means soil based organisms are far more likely to arrive intact in the small intestines (where they need to be) than lactobacteria. It also means that products containing soil-based organisms can provide fewer colony forming units and still be effective. That is, probiotic supplements with soil based organisms are more efficient at getting CFUs into the small intestines. It also eliminates or reduces the need for special coatings,  manufacturing processes, or “delivery systems” that must be created as a means to improve delivery rates of lactic acid bacteria.

Soil based organisms have also been shown to colonize the gut more effectively than lactic-acid bacteria. This may partially relate to the fact that they are hardier and make it to the small intestines in greater numbers. A major benefit is that this characteristic of SBOs may allow a reduction is dosage onto a “maintenance” level sooner without concerns that benefits of probiotic supplementation will disappear.

PRESCRIPT-ASSIST™ BROAD-SPECTRUM PROBIOTIC & PREBIOTIC

We at Health Products Distributors, Inc. researched various products containing soil based organisms. We choose to carry Prescript-Assist™, which is an effective and well-regarded broad spectrum probiotic and prebiotic formula.

Prescript-Assist™ provides 29 naturally resilient strains that support your body’s natural intestinal balance. Having so many strains means that this formula better reflects the great microbial diversity of the intestines versus typical probiotic products. In fact, more than 1,000 different species of microbes inhabit the human gut. Prescript-Assist™ includes Bacillus subtilis, which is a well-proven probiotic species found in traditional foods.

Below is a complete list of the strains of soil based organisms provided by Prescript-Assist. One 600 mg capsule of Prescript-Assist includes the following microorganisms (as well as the prebiotic Leonardite):

Arthrobacter agilis, Arthrobacter citreus, Arthrobacter globiformis, Arthrobacter luteus, Arthrobacter simplex, Acinetobacter calcoaceticus, Azotobacter chroococcum, Azotobacter paspali, Azospirillum brasiliense, Azospirillum lipoferum, Bacillus brevis, Bacillus marcerans, Bacillus pumilus, Bacillus polymyxa, Bacillus subtilis, Bacteroides lipolyticum, Bacteriodes succinogenes, Brevibacterium lipolyticum, Brevibacterium stationis, Kurthia zopfii, Myrothecium verrucaria, Pseudomonas calcis, Pseudomonas dentrificans, Pseudomonas fluorescens, Pseudomonas glathei, Phanerochaete chrysosporium, Streptomyces fradiae, Streptomyces cellulosae, Streptomyces griseoflavus.

The number and types of species found in the gastrointestinal (GI) tract can be a major difference between a well functioning digestive system and immune system, and those less than optimally functional. In scientific studies, individuals exhibiting higher levels of gastrointestinal distress and gut irregularities have been found to have a correspondingly lower variety of beneficial bacteria in the intestines.

Benefits of Probiotics soil based organisms

Benefits of probiotics, including SBO formulas like Prescript-Assist

INHERENT VIABILITY

Prescript-Assist™ is a clinically proven probiotic supplement designed to ensure maximum viability of the many organisms it provides. The formula offers inherent viability because the species it provides are naturally adapted for survival in the human gastrointestinal tract. That is, these 29 species are environmentally based (SBO) species drawn from the terrestrial microbiome where they have prospered and adapted for millenia to beneficially coexist with humans.

Unlike conventional Lactobacillus and Bifidobacterium probiotics, the strains in Prescript-Assist are a balanced formulation of a new generation of probiotics, capable of forming a protective shield until reaching the probiotic-friendly environment of the intestines. These organisms are resistant to acid, bile, and heat. In fact, routine testing of Prescript-Assist confirms it has a 95% viability two years after date of manufacture.

The inherent viability of the soil based organisms in Prescript-Assist means there are no requirements for nano-encapsulation or hard-shelled enteric-coated capsules, which both are essentially attempts to force viability of probiotic species rather than utilizing hardy strains naturally preadapted to our bodies.

Typical probiotic formulas therefore contain the relatively low-viability lactic acid bacteria that must be protected by technologies (e.g., microencapsulation) due to their inherent fragility. These fragile bacteria have a difficult time surviving because they are readily destroyed within the acidic environment of the stomach. Although patented enteric coatings can help survival rates, the provision of high-viabiltiy organisms that reach the intestines intact due to the inherent strength of their natural spore structure makes more sense as a means to protect against degradation in the stomach and intestinal tract.

Prescript-Assist™ provides bacteria that reach the intestines intact due to the fact that the spore structure protects against degradation or destruction by stomach acids.

probiotics-pros-cons soil based organisms

Benefits of soil based organisms in Prescript-Assist versus lactic acid bacteria formulas

29 SYMBIOTIC SPECIES FOUND IN ORGANIC, FERTILE SOILS

Science has shown that a baby’s exposure to maternal bacterial cultures during natural birth help it to form a healthy, disease-resistant bacterial defense. Likewise, the environmental and soil-based bacteria commonly found in foods grown in fertile organic soils assist in growing and maintaining a healthy makeup of internal flora in humans.

This is the basis of SBO (soil based organism) probiotics like Prescript-Assist.™ SBO probiotics have risen in recognition recently as clinical evidence grows to support their effectiveness. Species from the Bacillus genus, a gut-adapted spore-forming bacteria found in Prescript-Assist, have been demonstrated safe and effective in in vitro and in vivo studies (see Resources section below).

Dr. Mehmet Oz of the Dr. Oz Show says, “Spore form probiotics are the Chuck Norris of probiotics: total tough guys. They have to be to survive splashing around in your stomach’s acid bath. Wimpier types—including live cultures in yogurt—often throw in the towel.”

Among brands of SBO probiotics, Prescript-Assist offers the greatest diversity of species. It is the diversity and the resilience of the Prescript-Assist formulation that accounts for its proven success in peer-reviewed, published clinical trials.

BROAD SPECTRUM DIVERSITY

The Human Microbiome Project (NIH-funded five-years research study by a consortium of nearly 80 universities and institutions) confirmed that the number of microbial species found in the human intestines numbers in the thousands rather than hundreds.

Just as importantly, the project results showed that the distribution of a variety of strains capable of performing similar tasks is more important than the individual species themselves. This information underscores the importance of broad spectrum diversity, and therefore the role that can be played by multi-strain probiotic complexes, such as Prescript-Assist.

microbes over time soil based organisms

Soil based organisms in the human microbiome change during the life cycle.

A review article in Cell refers to the gut as a “natural laboratory for studying the ‘microevolution’ of humans.” The authors write: “In this view, we are seen as superorganisms composed of an amalgam of both microbial and H. sapiens cells, where the survival of microbe and human is interdependent.”

With its balanced formulation of 29 beneficial strains selected to mimic the natural flora found in traditional and paleolithic diets, Prescript-Assist is the only professional-grade probiotic to contain 29 species, 12 different genera, and all four of the most common phyla found in the human digestive tract, including Firmicutes, Bacteroidetes, Actinobacteria, and Proteobacteria.

soil based organisms human skin

Prevalence on skin sites of different types of bacteria, including soil based organisms.

ADDITIONAL ADVANTAGES OF PRESCRIPT-ASSIST™ PROBIOTIC FORMULA

SHELF STABILITY (NO REFRIGERATION NEEDED)

Prescript-Assist offers exceptional shelf stability. It is well known that conventional probiotics (i.e., lactic acid bacteria) are readily damaged, degraded, and destroyed by heat and pressure during the manufacturing process. They are also degraded by exposure to light and by temperature changes. Because they lack shelf stability, if they are not kept refrigerated, they often cannot provide a sufficient quantity of organisms by the time of ingestion.

In contrast, Prescript-Assist features probiotic bacteria protected by a durable seed-like structure, so that they are better safeguarded against environmental factors, including heat, pressure, light, or temperature variability. Indeed, testing confirms that the probiotic bacteria in Prescript-Assist remain 95% viable two years after their date of manufacture without any need for refrigeration.

PREBIOTIC SUPPORT – LEONARDITE (FULVIC & HUMIC ACIDS)

Most probiotic formulas do not contain any prebiotics, which are a food source for bacteria, and help accelerate their growth. Prescript-Assist uniquely contains Leonardite, which is a prebiotic mixture of humic and fulvic acids, which allows the beneficial bacteria to proliferate and thrive.

Fulvic and humic acids belong to a group of organic substances called humic substances. These are dark brown constituents of humus found in soil that contribute to the character of soil, and are precursors to fossil fuels. They are also found in peat, coal upland streams, dystrophic lakes, and ocean water. Both humic acid and fulvic acid are excellent chelators and powerful antioxidants.

Humic acid is normally found in the form of “humate” (the salt of humic acid), i.e., humic acid bound to a nutritional mineral element. Fulvic acid is normally found in the form of ‘fulvate’ (the salt of fulvic acid), i.e., fulvic acid bound to a nutritional mineral element.

A substantial fraction of the mass of the humic acids is in carboxylic acid functional groups, which endow these molecules with the ability to chelate (bind) positively charged multivalent ions (Mg2+, Ca2+, Fe2+, Fe3+, most other “trace elements” of value to plants, as well as other ions that have no positive biological role, such as Cd2+ and Pb2+).

This chelation of ions is probably the most important role of humic acids with respect to living systems. By chelating the ions, they facilitate the uptake of these ions by several mechanisms, one of which is preventing their precipitation, another appears to be a direct and positive influence on their bioavailability.

Humic acid and fulvic acid have been the subject of many years of scientific study not only because of their role in soil and plant biology, but also with respect to their chelation capabilities. That is, for their proven capacities in removing heavy metals from the human body.

Humic and fulvic acids bind only with double valency positive cations, i.e., nutritional elements and/or heavy metal ions. It is likely that a heavy metal ion will displace a lighter, nutritional metal ion and bind with the humate or fulvate.

Many health care practitioners recommend fulvic acid as an electrolyte (to increase cellular electrical efficiency) and supplement to take in combination with trace mineral supplements in order to assist in their uptake by the body. Fulvic acid bonds with these minerals. Because it is a small molecule and therefore easily able to pass through cell membranes, it allows delivery of the minerals efficiently into cells.

Most products are based on processed humate, taken from high quality soil sources, containing large amounts of nutritional cations already bound into the matrix. They are therefore not likely to deplete an individual’s mineral levels. As fulvic acid/fulvate is the smaller molecule, it is more easily absorbed into the cells. It is regarded as an excellent method of delivery for trace elements and nutrients into the body, as well as being an excellent chelator.

Observed Effects of Humic Acids on Animals

Our focus in this article is upon the effects of soil based organisms and prebiotics (e.g., humic and fulvic acids) in humans. However, it is worth noting that various animal studies show a large number of benefits. These studies show the following benefits:

Covering mucous membrane and adstringent effects

Humic acids can form a protective film on the mucuous epithelium of the gastrointestinal tract against infections and toxins. The macrocolloidal structure of humic acids ensures a good shielding on the mucous membrane of the stomach and gut, the peripheral capillaries, and damaged mucosal cells. As a result of this process, the resorption of toxic metabolites is reduced or fully prevented, especially after infections, in case of residues of harmful substances in foods. Furthermore, humic acids help to prevent excessive loss of water via the intestine.

Antibacterial and virucidal effects

Humic acids can influence the metabolism of proteins and carbonhydrates of microbes by catalytic means. This leads to a directly damaging effect against bacteria or viruses. A second mechanism is related to the interionic bonds of high-molecular protein fractions (toxins) of infectious microbes. Their toxic impact on physiological processes of mucous membrane cells can be weakened considerably or even completely blocked.

Antiphlogical effects

Dermal, oral, or subcutaneous application of humic acids leads to inhibitory effects on inflammation. The ability to inhibit inflammation is considered to be related with the flavonoid groups contained in humic acids.

Antiresorptive and adsorptive effects

As high-molecular humic acids remain in the gastrointestinal tract almost entirely following the enteral application (there is no self-resorption), antiresorptive and adsorptive effects take place where they are needed—in the digestive tract. Primarily cationoid noxes (protein toxins, toxic substances) are fixed, their resorption is reduced considerably or even prevented completely and their elimination through the bowel is promoted. As adsorption by humic acids includes not only physical and chemical reactions, but also complex-formation and ion-exchange, it is more intensive and dynamic compared to purely physical adsorbents.

Effects on the immune system

Humic acids stimulate the resistance forces of the body and lead to an increase in the phagocytosis activity. The inducer effect of phenolic components (groups) of humic acids is believed to be responsible for the immunological effects and is the basis for the success of the treatment of the so-called “factor” diseases in young animals.

Ergotropic effects

Humic acids stabilize the intestinal flora, thereby ensuring improved utilization of nutrients in foods. This leads to an increase in liveweight of the animal without increasing the amount of feed given to the animal.

 

prescript-assist-probiotic-fsmall soil based organisms

Prescript-Assist provides 29 strains of beneficial soil based organisms.

BACKED BY SCIENCE

Probiotic supplement formulas typically do not offer product-specific clinical studies validating their effectiveness. Prescript-Assist™ is different. It is supported by a peer-reviewed, placebo-controlled human clinical trial, and a one-year follow-up study that verifies its long-term efficacy.

Below is a summary of major features and benefits provided by Prescript-Assist™.

SUMMARY OF KEY BENEFITS

  • No Need for Refrigeration.
  • Backed by Sound Science: Supported by peer-reviewed, published clinical studies.
  • Inherent Organism Viability: A matrix of superior, highly resilient microflora whose organic, seed-like structures survive the early GI tract to thrive in the intestines.
  • Contains Bacillus subtilis:  A proven probiotic species found in traditional foods.
  • 29 Symbiotic Organisms: A balanced formulation specially selected to mimic the natural flora found in traditional and paleolithic diets.
  • Proven Shelf Stable:  With variations of less than 5% over two years from date of manufacture when stored at 98°F / 37°C
  • Supported By Prebiotics. Includes Leonardite, a prebiotic mixture of humic and fulvic acids, which allows beneficial bacteria to proliferate and thrive.
  • Gluten-Free, Dairy Free, and Vegan.

DIRECTIONS FOR USE

As a dietary supplement for adults, take 1–2 capsules per day, or as directed by your health care professional. May be taken with or without food.

Storage:

No refrigeration necessary. Store under normal conditions.

Shelf Life:

Routine viability testing confirms greater than 95% viability two years after date of manufacture — without refrigeration. See individual package for expiration dates.

A VIABLE PROBIOTIC FORMULA WITH SOIL BASED ORGANISMS

We at HPDI always strive to bring our customers the best products and formulas available whether or not we ourselves design and produce them.

When the opportunity to carry Prescript-Assist™ arose, we were quick to recognize its many benefits and advantages. We offer this unique formula knowing that it is safe, effective, and can help improve the health of our customers and their patients.

We also know that Prescript-Assist can be used effectively in combination with our other supplements (i.e., HPDI foundational supplements and superfoods), including formulas we design specifically for GI health like Intestinal Rejuvenation Formula.

We take Prescript-Assist™ and experience major health benefits. In addition, we personally witness and hear from many individuals (including health care professionals) who have experienced the benefits of the formula. The results reported are excellent.

It is more important than ever to utilize our current (and rapidly expanding) knowledge about the human microbiome and its constituents to support optimal health and wellness. Science tells us that the human microbiome historically has been populated by a broad range of soil based organisms.

Where we have moved away from nature and traditional agriculture, individuals’ microbiomes can become less vibrant, diverse, and robust. Supplements like Prescript-Assist providing soil based organisms can help bring us closer to having a microbiome more closely resembling our healthy ancestors.

SOURCES AND RESOURCES

BOOKS, ARTICLES & INFORMATION

The Advantages of Soil Based Organisms for Health (from the HPDI blog)

A New View of the Role of Bacteria in Health (from the HPDI blog)

Prescript-Assist™ Broad Spectrum Probiotic & Prebiotic (from the HPDI blog)

Spore Form Probiotics Keep Your Digestive Tract Happy

Body’s Hardworking Microbes Get Some Overdue Respect (Science)

NIH Human Microbiome Project Defines Normal Bacterial Makeup of the Body (NIH)

Ecological and Evolutionary Forces Shaping Microbial Diversity in the Human Intestine (Cell)

Brain Maker: The Power of Gut Microbes to Heal and Protect Your Brain –for LifeDavid Perlmutter, MD.

SELECTED ABSTRACTS

The Safety of Bacillus subtilis and Bacillus indicus as Food Probiotics (J. Applied Microbiology)

The Safety of Two Bacillus Probiotic Strains for Human Use (Digestive Diseases and Sciences)

PRODUCT INFORMATION

Prescript-Assist™ Probiotic Formula (HPDI website)

Intestinal Rejuvenation Formula (HPDI website)

ADDITIONAL RESOURCES

HPDI BLOG ARTICLES

Contact Us:

You can reach HPDI by calling 1-800-228-4265, email support(at)IntegratedHealth.com, or visit the retail website: www.IntegratedHealth.com

Health care professionals and retailers can apply for wholesale account, which includes access to the HPDI reseller website: www.HealthProductsDistributors.com