There’s a new kind of super-antioxidant formula in town. It will quench your free radicals in ways you never conceived. It’s called Ultimate Protector+. Its benefits are many due to a triple-action design that includes instructing cells to make their own antioxidants, a process known as Nrf2 activation. The benefits range from anti-aging and anti-inflammatory effects to support for immunity, brain function, and cardiovascular health. Your body depends on antioxidants to defend it from oxidative stressors. And Ultimate Protector+ defends you like nothing else can.
Ultimate Protector+ is among the world’s premier Nrf2 antioxidant supplements. It started when Dr. Hank realized that a triple-mode formula could best leverage the antioxidant powers available via Nrf2 activators in supplement form. That is, he could develop an ultra-effective Nrf2 activator-antioxidant formula by combining 1) non-GMO vitamin C, 2) potent exogenous (external) antioxidants from plant substances, and 3) plant-based Nrf2 transcription factor activators for endogenous (internal) antioxidant production within cells.
Dr. Hank designed Ultimate Protector+ to provide the most comprehensive antioxidant protection going beyond any supplement. The proof of his design methodology is the fact that one serving (six small capsules) of Ultimate Protector+ provides nearly 1,000,000 ORAC6.0 units. The ORAC6.0 test from Brunswick Labs measures how effectively an antioxidant can perform against six different free radicals: hydroxyl, peroxyl, peroxynitrite, singlet oxygen, superoxide anion, and hypochlorite (hypchlorous acid).
Most antioxidant supplements may effectively quench one or two types of free radicals. What makes Ultimate Protector+ different is its unique capacity to quench all six major free radicals. Ultimate Protector+ provides a significant edge in defending your body against the full spectrum of oxidants encountered in daily life.
The distinctive advantage of balanced free radical defense against a broad spectrum of oxidants distinguishes Ultimate Protector+ as a premier antioxidant and anti-aging supplement. This also makes it a “go-to” formula for supporting strong immunity, mitigating the effects of inflammation, enhancing brain function, boosting cardiovascular health, etc., as well as generally maintaining high antioxidant status in cells.
ULTIMATE PROTECTOR+ TEST RESULTS
Looking at the Brunswick Labs’ ORAC6.0 test results (from August 2019) for Ultimate Protector+, you see various oxidants (hydroxyl radical, peroxyl radical, singlet oxygen, etc.) are quenched at somewhat different levels. What is most important is that all six types are quenched, and that the total level of antioxidant protection—968,237 µmole TE/gram—is extremely high. To get an idea of how high that level of protection is, consider that a typical “good” antioxidant supplement might provide about 7,000–10,000 µmole TE/gram.
Specifically, the test results for Ultimate Protector+ show values of 3,376 µmole TE/gram for peroxyl radicals, 5,569 µmole TE/gram for hydroxyl radicals, 2,758 µmole TE/gram for peroxynitrite radicals, 221,866 µmole TE/gram for superoxide anion radicals, 34,169 µmole TE/gram for singlet oxygen radicals, and 5,005 µmole TE/gram for hypochlorite radicals. The table (below) shows for each free radical type the ORAC6.0 daily values for six capsules of Ultimate Protector+ containing 3.55 grams of the formula.
The overall daily ORAC6.0 value for six capsules (3.55 g) is obtained by adding the values for each free radical type. The total of 968,237 units is calculated by multiplying 272,743 units x 3.55 gram serving). To our knowledge there is no other Nrf2 or antioxidant formula that comes close to providing the complete protection of Ultimate Protector+ in terms of breadth of coverage and overall strength.
Ultimate Protector+ is a next generation cell protection formula that simultaneously meets the body’s needs for 1) high levels of Vitamin C, 2) full spectrum antioxidants (including polyphenols, flavonoids, anthocyanidins, oligomeric proanthocyanidins, catechins, curcuminoids, ellagic acid, pterostilbene, resveratrol, chlorogenic acid, xanthines, punicalagins, quercetin, zeaxanthin, carotenoids, polysaccharides, quinic acid, and more), and 3) many of the most protective enzyme activators (Nrf2 activators) — in a single product! This potent combination of characteristics distinguishes the formula because no other single formula available today offers such complete protection.
Ultimate Protector+ supplies nutrients that provide anti-aging, anti-inflammatory, and pain relieving effects, as well as ultra-high levels of antioxidant protection. Damage to cells caused by free-radicals contributes to many degenerative health conditions and to the aging process. This formula effectively supports the body in combating adverse effects of free-radicals.
ULTIMATE PROTECTOR+ BENEFITS
• Pain relief
• Acts to support the body regarding brain function, cardiovascular conditions, hypertension, and supports strong immunity
• Ultra powerful free radical defense. Helps prevent and mitigate free radical damage that contributes to conditions of poor health.
• Facilitates the body’s internal production of antioxidant enzymes within cells by supplying many powerful natural Nrf2 transcription factor activators
• Ultra effective, high potency, best-in-class antioxidant protection
ULTIMATE PROTECTOR+ FEATURES
• Plant Based Nrf2 Activators Potentiate the Body’s Internal Antioxidant Systems
• Ultra-High Antioxidant Potency as measured by ORAC6.0 testing to be over 968,000 micro moles TE per serving!
• Complete Formula Defends Body Against All Six Major Classes of Free Radicals including: 1) peroxyl, 2) hydroxyl, 3) peroxynitrite, 4) singlet oxygen, 5) superoxide anion, and 6) hypochlorite
• Provides 12+ Fruit- and Vegetable-Based Antioxidants and Nrf2 Activators to Offer Full Spectrum Protection
• Synergistic Formula Combines Effects of Endogenous (Internally Produced) Antioxidants, Exogenous (externally supplied) Antioxidants, and Vitamin C
• 100% non-GMO Ingredients (includes non-GMO Vitamin C)
• Contains calcium and magnesium malates supporting ATP & enzyme production
• Includes BioPerine ® a black pepper extract that significantly enhances the absorption of all of the nutrients in the formula
• Veggie Capsules (suitable for vegetarians and vegans)
• Easy to Take. Just six small capsules daily provides optimal antioxidant protection.
• Best in Class Cell Protection
ULTIMATE PROTECTOR+ INGREDIENTS
Ultimate Protector+ contains USP-grade non-GMO Vitamin C, SFB® standardized fruit blend (~50% polyphenols, high-ORAC powder: 9,000 µmole TE/g) from Grape, Cranberry, Pomegranate, Blueberry, Apple, Mangosteen, Bilberry, Chokeberry, and Goji Berry), Curcumin (standardized extract with 95% curcuminoids), Trans-Resveratrol (98% from Giant Knotweed), Green Tea Extract (93% polyphenols, 50% EGCG), VinCare® Whole Grape Extract (>80% polyphenols, ORAC>19,000 µmole TE/g), Calcium Malate, Magnesium Malate, and Bioperine® (a patented black pepper extract that enhances absorption of all ingredients and is a known Nrf2 activator).
Ultimate Protector+ is contained in a capsule suitable for vegetarians (i.e., a veggie cap) and contains no magnesium stearate.
ULTIMATE PROTECTOR+ RECAP
Ultimate Protector+ satisfies three distinct needs: 1) The need for a non-GMO Vitamin C product. That is, a Vitamin C formula that avoids genetically modified sources, 2) The need for a single powerful antioxidant formula. That is, a single, easy-to-take antioxidant formula offering a broad range of extremely high ORAC6.0 plant source #antioxidants, and 3) The need for a supplement providing a full spectrum of many of the most powerful Nrf2 activators. That is, a supplement providing a wide range of natural #Nrf2 transcription factor activators that allow the body to make its own antioxidant enzymes (e.g., superoxide dismutase (SOD), catalase, heme oxygenase, and glutathione peroxidase).
Ultimate Protector+ is an invaluable supplement for individuals requiring a high-quality, high-potency, and highly effective antioxidant supplement providing exceptionally well-rounded antioxidant protection against a broad range of free radicals. It has a unique triple action capacity to provide the nutrients required by the body for maximum free-radical defense, including plant-based Nrf2 activators that allow cells to produce their own antioxidants.
Providing nearly one million ORAC6.0 units is just one of the ways Ultimate Protector+ supports optimal health. Combining super antioxidant power with non-GMO vitamin C and Nrf2 activators makes Ultimate Protector+ an ideal choice for anyone seeking the highest levels of antioxidant protection.
The scientific evidence for Vitamin D3 continues piling up. It is abundantly clear a large percentage of the global population is deficient in Vitamin D3, and that supplements can make a huge difference for people to avoid and prevent deficiency of this critical nutrient.
During a period when people are self-isolating and mostly indoors—and there is an immediate coronavirus threat—it is time to act on the science supporting Vitamin D3.
It is now well known that Vitamin D plays critical roles in fighting viruses and building immunity. Many doctors now routinely advise patients to take high doses of Vitamin D3, especially in the winter when both Vitamin D levels and sun exposure are lowest.
“I have found the value of bolstering immune function with Vitamin D to be incredibly powerful.” – Dr. Jeffery Rutersbusch
William Grant, PhD, says: “Coronaviruses cause pneumonia as does influenza. A study of the case-fatality rate from the 1918-1919 influenza pandemic in the United States showed that most deaths were due to pneumonia. The SARS-coronavirus and the current China coronavirus were both most common in winter, when vitamin D status is lowest.” [1–5]
VITAMIN D3 PLUS
VITAMIN D3 PLUS is HPDI’s complete vitamin D3 formula. It was designed by Hank Liers, PhD to not only provide Vitamin D3, but also Vitamin K2 and Vitamin A both of which support the body’s uptake and use of Vitamin D3.
We have covered Vitamin D3 in previous posts such as Vitamin D3 Superstar! and Vitamin D3 for Health, and various other articles. In fact, Dr. Hank formulated Vitamin D3 PLUS 10 years ago, and it has become one of our best-selling products. As the general understanding that Vitamin D3 is critical for health increased, more people are taking action to supplement their diet with supplements like Vitamin D3 PLUS.
VITAMIN D3 PLUS is designed as an advanced Vitamin D formula providing high-dose Vitamin D3. Vitamin D3 is the natural form of Vitamin D produced in the body from sunlight and is the form best used for therapeutic purposes.
One softgel capsule of Vitamin D3 Plus provides 125 mcg (5,000 IU) of Vitamin D3 derived from highly purified and molecularly distilled fish liver oils. In addition, the product contains 300 mcg (1,000 IU) of Vitamin A also derived from highly purified and molecularly distilled fish liver oils and 10 mcg of Vitamin K2 from menaquinone-7.
Vitamin D3 Plus includes synergistic nutrients known to enhance absorption and use of Vitamin D3 in the body. These nutrients include Vitamin K2 (menaquinone-7) (10 mcg), which which works together with Vitamin D to help boost bone density, improve cardiovascular health, and boost immunity.
Vitamin D3 Plus also provides 300 mcg (1,000 IU) of Vitamin A, a nutrient known to work powerfully with Vitamin D to help create optimal health. As dosages of Vitamin D increase, ideally your dosage of Vitamin A also will increase, and vice versa. The formula also includes natural Vitamin E as an antioxidant.
Vitamin D3 Plus incorporates advanced softgel encapsulation
IMPORTANT VITAMIN D FACTS
In a world of sun avoidance, sun blocks, working indoors, latitudinal effects, etc., nearly the entire population suffers in multiple ways from Vitamin D3 deficiency
Human beings optimally produce 10,000–20,000 IU of Vitamin D3 (cholecalciferol) when exposed to full sunlight on a significant portion of skin for about 30 minutes
The body starts to gain the full benefits of Vitamin D3 only after it produces (or intakes orally) about 5,000 IU Daily
Vitamin D3 is a prehormone with powerful effects and with few exceptions cannot be obtained in sufficient amounts from diet
VITAMIN D3 PLUS FORMULATED FOR OPTIMAL HEALTH
Vitamin D3 is a fat-soluble vitamin increasingly known as a nutrient essential for health and well-being. Recent studies show that almost all body systems benefit from adequate Vitamin D intake/production. Therefore, it is important that the body receive optimal amounts in order to build the best health. In fact, recent studies indicate that 5,000 IU of Vitamin D3 is an ideal amount for daily intake. What is notable about this amount is that the body does not gain the full benefits from Vitamin D until it reaches this “threshold” level of about 5,000 IU. While the body stores Vitamin D, it must first be given an adequate supply.
Because Vitamin D3 is important for all body systems, the benefits of adequate Vitamin D are numerous. Adequate Vitamin D not only helps to ensure good health, but also supports the body in preventing and combating a wide range of conditions. When taken in adequate dosages (one or two 5,000 IU capsules daily), Vitamin D3 can provide the following benefits: 1) stronger bones, 2) enhanced immunity, 3) protection from autoimmune diseases, 4) improved blood sugar control, 5) normalized blood pressure, 6) prevention of tumors, 7) protection against flu, 8) better balance, 9) prevention of autism, 10) improved mood, 11) reduction of chronic pain, 12) improved dental health, 13) improved muscle strength, 14) prevention of birth defects, 15) improved prostate health, 16) better bowel health, 17) supports individuals with Multiple Sclerosis, 18) reduced symptoms of PMS, and 19) many other benefits.
The oils in Vitamin D3 Plus are emulsified by the addition of a non-GMO sunflower lecithin that ensures excellent uptake by the body. Vitamin E as tocopherols and tocotrienols derived from Oryza rice bran oil are included to protect against oxidation in the product and in the body. In addition, the rice bran oil is used to enhance the absorption of the fat-soluble Vitamin D and Vitamin A.
Vitamin D deficiency currently is a worldwide epidemic with more than one billion people at risk for diseases associated with low Vitamin D status. Vitamin D is proven safe and effective for a wide range of health conditions (see above and below). There are various reasons for this epidemic, including a significant portion of the world’s population living in northerly latitudes (where sunlight is inadequate during many months of the year), sun avoidance, time spent indoors, etc.
VITAMIN D3 MORE EFFECTIVE THAN D2
Vitamin D3 Plus provides only the Vitamin D3 form of Vitamin D. We avoid the use of Vitamin D2. Vitamin D2 has greater potential for toxicity, poorer absorption, and reduced effectiveness. Vitamin D3 is the preferred form of Vitamin D…and the form that gives you the best health.
VITAMIN D3 PLUS FROM HIGHLY PURIFIED FISH LIVER OIL
Vitamin D3 Plus provides Vitamin D3 from purified fish (cod) liver oil. Our formula comes in a softgel (instead of a standard capsule) for greater purity. In a softgel, the oil does not contain other ingredients (like cornstarch) commonly used to microencapsulate Vitamin D oil into powders used in capsule forms. The softgel form allows us to avoid using undesirable fillers and excipients. This means you avoid undesirable additives.
VITAMIN D3 PLUS OFFERS SUPERIOR ABSORPTION
Vitamin D3 PLUS includes non-GMO sunflower lecithin to act as an emulsifier of Vitamin D thereby ensuring effective absorption. In addition, the use of rice bran oil further supports absorption of fat-soluble Vitamin D. Optimizing absorption of Vitamin D is critical especially in cases of Crohn’s disease, Celiac disease (gluten intolerance), and irritable bowel syndrome. In these conditions, individuals often suffer from osteoporosis, kidney disease, etc. Better absorption means greater effectiveness.
NATURAL FORMS OF VITAMIN E PREVENT OXIDATION
Vitamin D3 PLUS includes Orzya rice bran oil because the fish liver oils in the formula are susceptible to oxidation. Oryza rice bran oil provides significant amounts of Vitamin E in the form of mixed tocotrienols and tocopherols, which are powerful antioxidants. These forms of Vitamin protect the product and keep Vitamin D3 Plus fresh, and act as powerful antioxidants in the body.
VITAMIN D3 PLUS INCLUDES VITAMIN A
Vitamin D3 Plus includes 300 mcg (1,000 IU) of Vitamin A along with Vitamin D3. We include Vitamin A because it is known that Vitamin A and Vitamin D act synergistically. Normal bone remodeling requires both Vitamin A and Vitamin D. In addition, when Vitamin D levels are inadequate, high dose Vitamin A may cause bone loss. However, no observed bone loss occurs when there are adequate levels of Vitamin D (more than 2,000 IU daily). Chris Masterjohn discusses the topic in his seminal article “Vitamin A on Trial: Does Vitamin A Cause Osteoporosis?” (see Weston A. Price Foundation website). Masterjohn states that Vitamin A taken in conjunction with Vitamin D is required for proper bone remodeling in the body. Vitamin A and Vitamin D not only act synergistically in the body, but also when taken together ensure protection from the effects of taking either one alone in high doses.
VITAMIN K2 REQUIRED FOR VITAMIN D FUNCTION
Vitamin D3 Plus includes 10 mcg of Vitamin K2 (the menaquinone-7 or MK-7 form) per softgel in our formula. Vitamin K2 (especially as MK-7) is necessary for the proper activation of bone matrix proteins by conferring on them the physical ability to bind calcium (i.e., to build strong bones). Research also shows that Vitamin K2 can help remove calcium from soft tissues in the body and instead put the calcium into bony structures (i.e., where it serves to build a strong skeletal system). Vitamin D3 Plus can help put the health-building powers of Vitamin K2 (as menaquinone-7) to work for optimal health.
Chris Masterjohn elegantly discusses the role of Vitamin K2 in bone formation in his groundbreaking article “On the Trail of the Elusive X-Factor: A Sixty-Two-Year-Old Mystery Finally Solved” (see Weston A. Price Foundation website). Because Vitamin K2 is needed to facilitate the function of Vitamin D in proper bone formation (including tooth structure), Masterjohn states that Vitamin D toxicity is most likely a case of Vitamin K2 deficiency. It is clear that adequate Vitamin K2 both protects against Vitamin D toxicity and supports the effective use of Vitamin D in the body.
In Health Benefits of Vitamin K-2: A Revolutionary Natural Treatment for Heart Disease and Bone Loss (2006), Larry Howard and Anthony Payne, PhD, assert that as little as 6 mcg (micrograms) of Vitamin K2 (as MK-7) can be beneficial. The half-life of Vitamin K2 (as MK-7) is about three days in the body. This means that as few as 6 mcg of Vitamin K2 is beneficial because the levels increase by a factor of three when its taken regularly.
It is notable that Vitamin K2 is found naturally in fermented foods, including some cheeses, sauerkraut, natto (i.e., a traditional Japanese dish of fermented soybeans), and in dairy products, eggs, and certain meats. However, the vast majority of individuals in the world do not receive adequate amounts of Vitamin K2 from their diets. Now anyone can gain the important benefits of Vitamin K2 along with the benefits of Vitamin D and Vitamin A by taking Vitamin D3 Plus.
Vitamin D is known as the sunshine vitamin.
VITAMIN D3 PLUS
NUTRITIONAL CONSIDERATIONS AND APPLICATIONS
Vitamin D, calciferol, is a fat-soluble vitamin. It is found naturally in some animal foods, but also can be made in the body after exposure to ultraviolet rays from the sun. It is known that season, latitude, time of day, cloud cover, smog, and use of sunscreens affect UV ray exposure. For example, in northern areas of the US the average amount of sunlight from November through February is insufficient to produce significant Vitamin D synthesis in the skin. Sunscreens with a sun protection factor (SPF) of 8 or greater will block UV rays that produce Vitamin D even in regions of the US where sunlight is plentiful.
The liver and kidney help convert vitamin D to its active hormone form. The major biologic function of Vitamin D is maintaining normal blood levels of calcium and phosphorus. Vitamin D aids in the absorption of calcium, helping to form and maintain strong bones. It promotes bone mineralization in conjunction with a number of other vitamins, minerals (especially magnesium), and hormones. While adequate sun exposure is an ideal means to obtain Vitamin D, most of the population cannot obtain sufficient sunlight during fall and winter months to maintain optimal Vitamin D levels. Vitamin D3 Plus offers a solution for keeping Vitamin D at optimal levels for health.
When there is insufficient Vitamin D in the body, bones can become thin, brittle, soft, or misshapen. Vitamin D prevents rickets (in children) and osteomalacia (softening of bones) (in adults). These skeletal diseases result in defects that can severely weaken bones. It is estimated that over 25 million adults in the United States either have developed osteoporosis or are at risk of developing it. Osteoporosis is a disease characterized by fragile bones. It results in increased risk of bone fractures. Vitamin D deficiency was recognized as the cause of rickets and osteomalacia 75 years ago. The prevention and cure of these diseases with fish liver oil was a triumph for nutritional science and since then the body’s requirement for Vitamin D has been linked to these conditions.
Vitamin D deficiency also has been associated with greater incidence of hip fractures. In older women, a higher Vitamin D intake from diet and supplements is associated with less bone loss. Vitamin D supplementation therefore may help prevent fractures resulting from osteoporosis and the loss of bone. Vitamin D supplements offer a significant means for strengthening bones and skeletal structures, and for preventing bone weakness or bone loss leading to osteomalacia, osteoporosis, and other conditions related to weak bones.
VITAMIN D SERVES MANY FUNCTIONS
Vitamin D affects major aspects of human health beyond its classical role in mineral metabolism. It is well established that the active form of Vitamin D acts an effective regulator of cell growth and differentiation in a number of different cell types. Laboratory, animal, and epidemiologic evidence strongly suggest that Vitamin D may be protective against some tumorigenesis. The active form of Vitamin D therefore plays a critical role in supporting good health.
Vitamin D deficiency has been associated with insulin deficiency and insulin resistance. It was shown recently that Vitamin D deficiency is likely a major factor for the development of type 1 diabetes in children. Insulin resistance is also one of the major factors leading not only to tumor formation, but also to heart disease—by far the leading cause of death in the USA. Northern countries have higher levels of heart disease and more heart attacks occur in the winter months.
Degenerative arthritis of the knee and hip progresses more rapidly in people who have lower concentrations of Vitamin D. Infertility is associated with low levels of Vitamin D, and PMS has been completely reversed by the addition of calcium, magnesium, and Vitamin D. Activated Vitamin D in the adrenal gland regulates tyrosine hydroxylase, the rate limiting enzyme necessary for the production of dopamine, epinephrine, and norepinephrine. Low Vitamin D levels also may contribute to chronic fatigue and depression. Seasonal Affective Disorder (SAD) has been treated successfully with Vitamin D.
Multiple Sclerosis, Sjogren’s Syndrome, rheumatoid arthritis, thyroiditis and Crohn’s disease have all been linked with low Vitamin D levels. It has been shown that long term low-level exposure to sunlight normalizes immune function and enhances immune cell production. This reduces abnormal inflammatory responses, such as those found in autoimmune disorders, and reduces occurrences of infectious disease.
Vitamin D deficiency also has been linked with obesity. Vitamin D recently has been shown to lower leptin secretion. Leptin is a hormone produced by fat cells and is involved in weight regulation. Obesity itself lessens the bioavailability of Vitamin D from skin and dietary sources because it is deposited in body fat. Vitamin D deficiency, moreover, has been clearly linked with Syndrome X (also known as Metabolic Syndrome). Syndrome X refers to a cluster of health conditions that includes insulin resistance (the inability to effectively process dietary carbohydrates and sugars), abnormal blood fats (e.g., elevated cholesterol and triglycerides), high blood pressure, and obesity.
VITAMIN A BENEFITS
Vitamin A is useful for many health conditions, including vision problems, poor thyroid function, and weakened immunity. Vitamin A is highly effective against infections (especially those that involve the mucous membranes) largely because it is critical to the formation of tissues lining the digestive, respiratory, reproductive, and urinary tracts. It is also required for the digestion of protein, and for lactation, reproduction, healthy skin and eyes, and the formation of steroid hormones. Vitamin A deficiency can result in a number of health problems, including night blindness, dry eyes, eye infections, and skin conditions. Vitamin A works together with Vitamin D and Vitamin K2 to maintain healthy bones. Vitamin D has been shown to prevent Vitamin A toxicity.Vitamin D3 Plus includes Vitamin A because Vitamin A and Vitamin D work together to support health.
VITAMIN K2 BENEFITS
Vitamin K2 in the form of MK-7 has been shown in numerous studies to extract calcium from the blood and arteries and deposit calcium into growing or aging bones. In addition, MK-7 appears to have the potential to prevent or even reverse some forms of heart disease and, at the same time, do the same for bone loss. It is believed that patients would be able to be treated with doses of vitamin D that possess greater therapeutic value than those currently being used while avoiding the risk of adverse effects by administering Vitamin D together with Vitamins A and K2. Vitamin D3 Plus includes Vitamin K2 (as MK-7) because MK-7 provides unique benefits for health that complement the benefits offered by Vitamin D. They act synergistically to provide other benefits beyond the benefits each by itself can provide.
VITAMIN D3 PLUS INFORMATION
COMPOSITION: One softgel capsule of VITAMIN D3 PLUS provides the following percentages of the US Daily Value for adults:
RECOMMENDATIONS: Recent research on Vitamin D suggests that most people will benefit from 125 mcg (5,000 IU) of Vitamin D3 daily (unless there is some constraining lifestyle factor or medical reason). Due to its long half-life (about 30 days) in the body, Vitamin D can be taken effectively in smaller doses if needed (e.g., 5,000 IU taken fewer times per week). For example, taking one capsule once per week would give a daily equivalent dose of about 714 IU (i.e., 5,000 IU divided by seven days).
Additional important nutrients you need to take with Vitamin D3 in order to achieve maximum benefits include magnesium, calcium, zinc, and boron. These additional nutrients are included in our foundational supplements (multivitamins, essential fats, Vitamin C formulas, and Rejuvenate!™ superfoods) and bone formulas (Bone Jour!™ and Bone Guardian).
DIRECTIONS: As a dietary supplement take one capsule of Vitamin D3 Plus daily with food, or as directed by a health care professional. Note: when exposure to direct sunlight is adequate, your requirements for supplemental Vitamin D may be correspondingly lower.
INGREDIENTS: Fish liver oil (providing Vitamin D3), bovine source gelatin (shell), glycerin (shell), yellow beeswax (shell), purified water (shell), rice bran oil, non-GMO sunflower lecithin, Oryza oil, turmeric powder (shell), Vitamin K2 (menaquinone-7), and fish liver oil (providing Vitamin A).
VITAMIN D3 PLUS does not contain wheat, rye, oats, corn, barley, soy, gluten, sugar, wax, egg, yeast, dairy, GMOs, sulfates, chlorides, coloring agents, or artificial preservatives.
2. Grant WB, Giovannucci E. (2009) The possible roles of solar ultraviolet-B radiation and vitamin D in reducing case-fatality rates from the 1918-1919 influenza pandemic in the United States. Dermatoendocrinol. 1:215-219. https://www.ncbi.nlm.nih.gov/pubmed/20592793.
3. Martineau AR, Jolliffe DA, Hooper RL et al. (2017) Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data. BMJ. 356:i6583. https://www.ncbi.nlm.nih.gov/pubmed/28202713.
5. Zhu N, Zhang D, Wang W, et al., China Novel Coronavirus Investigating and Research Team. (2020) A Novel Coronavirus from Patients with Pneumonia in China, 2019. N Engl J Med. 2020 Jan 24. doi: 10.1056/NEJMoa2001017. [Epub ahead of print] https://www.ncbi.nlm.nih.gov/pubmed/31978945.
Looking for an advanced antioxidant formula? Already using or recommending vitamin C? Curious about cellular Nrf2 activation? Look no further than PRO-C™.
PRO-C™ is among the most effective antioxidant formulas available. It is an HPDI foundational supplement that works most effectively when used with multivitamins, essential fats, and superfoods. However, it is also an excellent standalone formula that can rapidly provide the body with extremely high protection from free radicals.
We ourselves have taken PRO-C daily for many years with excellent results. Our personal experience together with detailed feedback from health professionals and end-users affirms the effectiveness of PRO-C as a super-antioxidant–vitamin C-Nrf2 activator formula.
PRO-C provides 500 mg of buffered vitamin C per capsule (buffered with calcium, magnesium, and zinc) along with grape extract (seed, skin, pulp) and green tea extract (95% polyphenols). In addition, we include a special combination of the “network antioxidants” l-glutathione (reduced), n-acetyl-l-cysteine (NAC), r-lipoic acid, and selenium. Vitamin B2 and Vitamin B6 in coenzyme forms support the enzymatic effectiveness of the “network antioxidants”. The formula works so well because this combination of ingredients leverages the antioxidant power of vitamin C, grape extract, green tea extract, and the other nutrients to act synergistically in order to maximize effectiveness.
FORMULATION HISTORY AND THE SCIENCE BEHIND PRO-C™
What you may not know is the history of the development PRO-C and the scientific knowledge on which Dr. Hank Liers based his formulation of it.
Dr. Hank formulated his first product in 1989. It was a potent antioxidant formula he called PYC-C™ (sounds like “pixie”). PYC-C consisted of a combination of buffered Vitamin C (including magnesium, calcium, and zinc ascorbates) and pycnogenols from pine bark.
By 1997 Dr. Hank had gathered a great deal of new scientific information regarding green tea catechins and the nutrients termed “network antioxidants” by Dr. Lester Packer, director of Packer Lab at University of California, Berkeley. Beyond this information, Dr. Hank studied additional research regarding how various nutrients worked together synergistically. At that point, he was ready to formulate the new, improved PRO-C™ super antioxidant formula.
PRO-C combines the ingredients of PYC-C (now known as OPC-C™) and uses grape pulp, skin, and seed extract with green tea extract (with high polyphenols >95% and EpiGalloCatechinGalate (EGCG) >45%), n-acetyl-l-cysteine (NAC), reduced glutathione (GSH), R-lipoic acid, selenium, and coenzyme Vitamins B2 and B6.
HPDI launched PRO-C™ in late 1997. It rapidly became one of our best-selling products. Our customers raved about how effective it was for them if they felt like they were “coming down with something” (like a cold, flu, virus, infection, etc.). Greater skin elasticity greatly helped pregnant women avoid stretch marks and episiotomies. Today, we highly recommend its use together with our other Foundational Supplements to ensure optimal health and anti-aging effects.
THE PRO-C™ SUPER ANTIOXIDANT FORMULA
PRO-C™ super antioxidant formula is extremely synergistic, especially in so far as it increases the body’s ability to quench free radicals in its aqueous (i.e., water-based) compartments. Because antioxidants may become free radicals themselves after they have done their job, the body has developed an elaborate system for recovery of oxidized antioxidants.
Dr. Lester Packer was the primary researcher investigating the synergistic character of antioxidants. He made this statement in his interview with Dr. Richard Passwater after publication of Packer’s The Antioxidant Miracle (1999):
” [The major theme of] The Antioxidant Miracle is that antioxidants work in a coordinated manner. They interact with one another, and this interaction, which we like to call the antioxidant network, is very important to the overall antioxidant defense that we possess. The key members of the antioxidant network are vitamin E and vitamin C, but there are other participants in this network. These are thiol antioxidants, antioxidants that contain sulfur groups in the body. Glutathione perhaps is the best known of these, but there are other sulfur-containing antioxidants that also are very important.”
Dr. Packer continues:
“This whole antioxidant network works like an orchestra depending on individuals who have, of course, different complements of antioxidants depending upon their nutritional regimens and the individuality of their own body metabolisms. The idea behind having a network of antioxidants is that if one antioxidant happens to be deficient the others can compensate and still keep the antioxidant defense system strong.”
The following diagram shows some of the relationships in the antioxidant network and how they support each other.
Figure 1 – Dr. Packer’s Antioxidant Network
We see, for example, reduced glutathione (GSH) has the ability to reduce oxidized Vitamin C back to its unoxidized state. Vitamin C reduces oxidized Vitamin E back to its unoxidized state, and both reduces glutathione and spares it for other important functions, including detoxification and immune enhancement.
Many polyphenols (e.g., oligomeric proanthocyanidins (OPCs), anthocyanidins and catechins) found in red grape and green tea extracts spare Vitamin C and glutathione in the body, as well as operate as powerful antioxidants, anti-inflammatories, and connective tissue strengtheners.
Grapes provide antioxidant nutrients such as polyphenols, OPCs, anthocyans, and resveratrol.
R-Lipoic Acid (see abstracts below) operates as an antioxidant both in its oxidized and reduced states, reduces the oxidized forms of both Vitamin E and Vitamin C, and and has been shown to enhance glutathione levels. Because several of these substances are able to protect Vitamin E contained in cell membranes, this combination also has a significant beneficial effect on the fat soluble antioxidant status of the body!
The nutrients in PRO-C have been carefully selected and balanced to provide optimal effects, especially as related to free radical protection, detoxification, immune system enhancement, connective tissue strengthening, and reduction of inflammation. PRO-C therefore provides outstanding nutritional support in a wide variety of conditions of poor health, as well as acts to support and maintain a state of health and well-being.
It the last several years the research results on Nrf2 activators have become well known and products developed that take advantage of these nutrients. For details see our blog article Natural Phytochemical Nrf2 Activators for Chemoprevention. Researchers have been studying specifically how enzyme-activating substances such as OPCs and anthocyans activate a transcription factor known as Nrf2 that causes the body to endogenously produce higher levels of a wide variety of protective enzymes including superoxide dismutase (SOD), catalase, and glutathione peroxidase.
Although we did not know about Nrf2 activators in 1997 when we formulated PRO-C, we have subsequently learned that four of the ingredients in the formula have powerful Nrf2 activity. These include grape seed extract, green tea extract, NAC, and r-lipoic acid. With this knowledge, we now understand that PRO-C provides both powerful external antioxidants (with extremely high ORAC5.0 values) that support redox cycles within the body, but also provides ingredients that allow the body to endogenously produce powerful protective enzymes for even greater free-radical protection and health.
PRO-C™ ANTIOXIDANT FORMULA INGREDIENTS
PRO-C contains buffered vitamin C (in the form of powdered calcium, magnesium, and zinc ascorbates), high-potency grape extract (from grape pulp, skins, and seeds), green tea extract (with>95% polyphenols and >45% EGCG), reduced glutathione, N-Acetyl-L-Cysteine (NAC), R-lipoic acid, coenzyme forms of vitamin B2 (R5P) and vitamin B6 (P5P), and selenium.
Below we will discuss each ingredient and show some of the research that confirms its effectiveness.
Vitamin C typically is called l-ascorbic acid or ascorbate and is an essential nutrient for humans and other animal species. The term “vitamin C” refers to a number of vitamins that have vitamin C activity in animals, including ascorbic acid and its salts (e.g., magnesium ascorbate, calcium ascorbate, sodium ascorbate, etc.), and some oxidized forms such as dehydroascorbate and semidehydroascorbate.
Vitamin C is known to perform many critical functions within the body involving detoxification, tissue building, immune enhancement, pain control, and controlling or killing pathogenic organisms. It is also known to be helpful for wound and bone healing, healthy skin and eyes, fighting infections, stress control, toxic exposure, and repairing damaged tissue of all types. For much more information on the many benefits of Vitamin C see our blog article Vitamin C – An Amazing Nutrient.
Below are two abstracts that show some of the beneficial effects of Vitamin C when used with other network antioxidants:
ABSTRACT 1: Exhaustive physical exercise causes oxidation of glutathione status in blood: prevention by antioxidant administration.
Sastre J, Asensi M, Gasco E, Pallardo FV, Ferrero JA, Furukawa T, Vina J
In: Am J Physiol (1992 Nov) 263(5 Pt 2):R992-5
We have studied the effect of exhaustive concentric physical exercise on glutathione redox status and the possible relationship between blood glutathione oxidation and blood lactate and pyruvate levels. Levels of oxidized glutathione (GSSG) in blood increase after exhaustive concentric physical exercise in trained humans. GSSG levels were 72% higher immediately after exercise than at rest. They returned to normal values 1 h after exercise. Blood reduced glutathione (GSH) levels did not change significantly after the exercise. We have found a linear relationship between GSSG-to-GSH and lactate-to-pyruvate ratios in human blood before, during, and after exhaustive exercise. In rats, physical exercise also caused an increase in blood GSSG levels that were 200% higher after physical exercise than at rest. GSH levels did not change significantly. Thus, both in rats and humans, exhaustive physical exercise causes a change in glutathione redox status in blood. We have also found that antioxidant administration, i.e., oral vitamin C, N-acetyl-L- cysteine, or glutathione, is effective in preventing oxidation of the blood glutathione pool after physical exercise in rats.
The effect of glutathione and vitamins A, C, and E on acute skin flap survival.
Hayden RE, Paniello RC, Yeung CS, Bello SL, Dawson SM
In: Laryngoscope (1987 Oct) 97(10):1176-9
Vitamins A, C, and E act as antioxidants and as free radical scavengers in biological systems. Glutathione is involved in several reactions in vitamin metabolism and also plays an important role in cell membrane protection against lipid peroxidation by free radicals. We sought to use these natural defense mechanisms against oxygen free radicals formed during reperfusion of ischemic skin flaps. An acute axial random skin flap model was utilized in the rat. Vitamins or glutathione were administered by oral gastric tube or intravenously in the perioperative period, and survival of the flap was measured at 1 week. Glutathione, beta-carotene, ascorbic acid and alpha-D- tocopherol showed mean flap survival of 84% to 89%, each of which was significantly improved over saline controls (67% p less than .0005). The mechanisms and biochemistry of these vitamins, and their interactions with other vitamins and with glutathione, are discussed, along with clinical implications of free radical scavenging and skin flap survival.
Grape extract (seeds, skin, pulp) contain highly bioavailable bioflavonoid complexes that in research studies have been shown to have powerful antioxidant capability. The Oligomeric Proanthocyanidins (OPCs) in grape seed extract are able to strengthen collagen fibers in aging or damaged connective tissue and can act as a preventative against connective tissue degradation.
Some research indicates that anthocyans, which are found in extracts of grape skin and stems (but not in grape seed extract), can reduce oxidized glutathione while at the same time become reduced themselves. In addition, extracts of grape skin and stems (but not those of grape seed extract) contain a material called trans-resveratrol that has been shown to have chemopreventive effects.
ABSTRACT 3: Protective effects of grape seed proanthocyanidins and selected antioxidants against TPA-induced hepatic and brain lipid peroxidation and DNA fragmentation, and peritoneal macrophage activation in mice. Bagchi D, Garg A, Krohn RL, Bagchi M, Bagchi DJ, Balmoori J, Stohs SJ
In: Gen Pharmacol (1998 May) 30(5):771-6
1. The comparative protective abilities of a grape seed proanthocyanidin extract (GSPE) (25-100 mg/kg), vitamin C (100 mg/kg), vitamin E succinate (VES) (100 mg/kg) and beta-carotene (50 mg/kg) on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced lipid peroxidation and DNA fragmentation in the hepatic and brain tissues, as well as production of reactive oxygen species by peritoneal macrophages, were assessed. 2. Treatment of mice with GSPE (100 mg/kg), vitamin C, VES and beta-carotene decreased TPA-induced production of reactive oxygen species, as evidenced by decreases in the chemiluminescence response in peritoneal macrophages by approximately 70%, 18%, 47% and 16%, respectively, and cytochrome c reduction by approximately 65%, 15%, 37% and 19%, respectively, compared with controls. 3. GSPE, vitamin C, VES and beta-carotene decreased TPA-induced DNA fragmentation by approximately 47%, 10%, 30% and 11%, respectively, in the hepatic tissues, and 50%, 14%, 31% and 11%, respectively, in the brain tissues, at the doses that were used. Similar results were observed with respect to lipid peroxidation in hepatic mitochondria and microsomes and in brain homogenates. 4. GSPE exhibited a dose-dependent inhibition of TPA- induced lipid peroxidation and DNA fragmentation in liver and brain, as well as a dose-dependent inhibition of TPA-induced reactive oxygen species production in peritoneal macrophages. 5. GSPE and other antioxidants provided significant protection against TPA-induced oxidative damage, with GSPE providing better protection than did other antioxidants at the doses that were employed.
ABSTRACT 4: Clinical and capillaroscopic evaluation of chronic uncomplicated venous insufficiency with procyanidins extracted from vitis vinifera
Costantini A, De Bernardi T, Gotti A
In: Minerva Cardioangiol (1999 Jan-Feb) 47(1-2):39-46
BACKGROUND: The pharmacological treatment of non-complicated chronic venous insufficiency is a current and well-debated topic. The introduction of new products with action on the venous system, improved knowledge on the physiopathology of venous insufficiency and the possibility provided by new analytical instruments, have given new impulse to the consolidation of the clinical value of phlebotonics in this indication. METHODS: In light of this, 24 patients with non-complicated chronic venous insufficiency were treated with oral administration of Oligomeric Proanthocyanidins (Pycnogenols-OPC) 100 mg/day. To evaluate the therapeutic efficacy of the treatment, an instrumental evaluation by optical probe capillaroscope was employed in addition to the traditional subjective clinical parameters: swelling, itching, heaviness and pain. The videocapillaroscope examination was performed at the lower third of the leg and the first toe. Edema in the capillaroscopic field, the number of observable capillaries and the capillary dilatation were the parameter chosen to evaluate the efficacy of treatment. All patients completed the study with no reports of adverse events during the period of observation. RESULTS: The results obtained show a positive clinical response (improved or absent symptoms) in over 80% of patients, with significant improvement of symptoms already evident after the first 10 days of treatment. The mechanism of action of the OPCs explains the rapid reduction of the swelling of the lower limbs and correlated with this are the other evaluable symptoms: heaviness and itching. Particularly striking results were observed for itching and pain which completely disappeared during the course of therapy in 80% and 53% of the patients respectively. Noteworthy is the good correlation between the clinical and instrumental data, with improvement in a total of 70% of patients. CONCLUSIONS: The results obtained in the course of this clinical experience, with evident improvement already during the first weeks of treatment, the absence of adverse events added to the benefit of a once-a-day administration, justify the use of OPC in the treatment of non-complicated chronic venous insufficiency.
Nuclear factor erythroid 2-related factor 2 (Nrf2) is an important transcription factor that regulates antioxidant response element (ARE)-driven phase II detoxification enzymes. In this study, induction of phase II enzymes via Nrf2/ARE activation in the cytoprotective effect of crude polyphenol extract (CPE), oligomeric procyanidin fraction (OPF), and polymeric procyanidin fraction (PPF) from defatted grape seeds in HepG2 cells was evaluated. Among these treatments, the treatment with PPF significantly increased Nrf2 protein expression in the nuclear fraction. Treating the samples increased heme oxygenase-1 (HO-1) and NAD(P)H:quinone oxidoreductase 1 (NQO1) protein expression in a dose-dependent manner, and PPF significantly increased the levels of phase II enzymes. Cellular generation of reactive oxygen species (ROS) were effectively reduced by PPF. These results suggest that pretreatment with PPF shows a cytoprotective effect by inhibiting ROS production and inducing HO-1 and NQO1 expression via Nrf2 activation in HepG2 cells.
GREEN TEA EXTRACT
Green tea extract is obtained from the unfermented leaves of Camellia sinensis for which numerous biological activities have been reported including: antimutagenic, antibacterial, hypocholesterolemic, antioxidant, and protective against tumorigenesis. Below we have selected a few of the many abstracts we have on file showing the benefit of green tea extract.
Green tea leaves are high in antioxidant polyphenols and catechins.
ABSTRACT 6: Enhancement of antioxidant and phase II enzymes by oral feeding of green tea polyphenols in drinking water to SKH-1 hairless mice: possible role in cancer chemoprevention.
Khan SG, Katiyar SK, Agarwal R, Mukhtar H
In: Cancer Res (1992 Jul 15) 52(14):4050-2
Following the oral feeding of a polyphenolic fraction isolated from green tea (GTP) in drinking water, an increase in the activities of antioxidant and phase II enzymes in skin, small bowel, liver, and lung of female SKH-1 hairless mice was observed. GTP feeding (0.2%, w/v) to mice for 30 days significantly increased the activities of glutathione peroxidase, catalase, and quinone reductase in small bowel, liver, and lungs, and glutathione S-transferase in small bowel and liver. GTP feeding to mice also resulted in considerable enhancement of glutathione reductase activity in liver. In general, the increase in antioxidant and phase II enzyme activities was more pronounced in lung and small bowel as compared to liver and skin. The significance of these results can be implicated in relation to the cancer chemopreventive effects of GTP against the induction of tumors in various target organs.
ABSTRACT 7: INHIBITORY EFFECT OF SIX GREEN TEA CATECHINS AND CAFFEINE ON THE GROWTH OF FOUR SELECTED HUMAN TUMOR CELL LINES. In: Anticancer Drugs (1996 Jun) 7(4):461-8
Institutional address: Department of Pharmacology and Toxicology College of Pharmacy University of Arizona Tucson 85721 USA.
Green tea is an aqueous infusion of dried unfermented leaves of Camellia sinensis (family Theaceae) from which numerous biological activities have been reported including antimutagenic, antibacterial, hypocholesterolemic, antioxidant, antitumor and cancer preventive activities. From the aqueous-alcoholic extract of green tea leaves, six compounds (+)-gallocatechin (GC), (-)-epicatechin (EC), (-)- epigallocatechin (EGC), (-)-epicatechin gallate (ECG), (-)- epigallocatechin gallate (EGCG) and caffeine, were isolated and purified. Together with (+)-catechin, these compounds were tested against each of four human tumor cells lines (MCF-7 breast carcinoma, HT-29 colon carcinoma, A-427 lung carcinoma and UACC-375 melanoma). The three most potent green tea components against all four tumor cell lines were EGCG, GC and EGC. EGCG was the most potent of the seven green tea components against three out of the four cell lines (i.e. MCF-7 breast cancer, HT-29 colon cancer and UACC-375 melanoma). On the basis of these extensive in vitro studies, it would be of considerable interest to evaluate all three of these components in comparative preclinical in vivo animal tumor model systems before final decisions are made concerning which of these potential chemopreventive drugs should be taken into broad clinical trials.
GLUTATHIONE AND N-ACETYL-L-CYSTEINE (NAC)
Glutathione and NAC (a major precursor of glutathione) both provide important protection against toxins and free radicals, and can strengthen the immune system. Glutathione is considered to be one of the most important protective substances in the human body with almost 60% of liver detoxification accounted for by this key substance. In addition, glutathione is one of the most potent anti-viral substances known.
Some research has indicated that glutathione may not be able to enter easily into certain types of cells, but NAC is able to enter these cells and be converted into glutathione once inside the cell. Thus, the combination of glutathione and NAC appear to be more potent than either alone.
ABSTRACT 8 GSH rescue by N-acetylcysteine.
Ruffmann R Wendel A
In: Klin Wochenschr (1991 Nov 15) 69(18):857-62
Reduced glutathione (GSH) is the main intracellular low molecular weight thiol. GSH acts as a nucleophilic scavenger and as an enzyme-catalyzed antioxidant in the event of electrophilic/oxidative tissue injury. Therefore, GSH has a major role as a protector of biological structures and functions. GSH depletion has been recognized as a hazardous condition during paracetamol intoxication. Conversely, GSH rescue, meaning recovery of the protective potential of GSH by early administration of N-acetylcysteine (NAC), has been found to be life-saving. Lack of GSH and electrophilic/oxidative injury have been identified among the causes of the adult respiratory distress syndrome (ARDS), idiopathic pulmonary fibrosis (IPF), and the acquired immunodeficiency syndrome (AIDS). Experimental and early clinical data (in ARDS) point to the role of NAC in the treatment of these conditions. Recently, orally given NAC has been shown to enhance the levels of GSH in the liver, in plasma, and notably in the bronchoalveolar lavage fluid. Rescue of GSH through NAC needs to be appreciated as an independent treatment modality for an array of different disease, all of which have one feature in common: pathogenetically relevant loss of GSH.
ABSTRACT 9 Cysteine and glutathione concentrations in plasma and bronchoalveolar lavage fluid after treatment with N-acetylcysteine.
Bridgeman MM Marsden M MacNee W Flenley DC Ryle AP
In: Thorax (1991 Jan) 46(1):39-42
N-acetylcysteine (600 mg/day) was given to patients by mouth for five days before bronchoscopy and bronchoalveolar lavage to determine whether N-acetylcysteine could increase the concentrations of the antioxidant reduced glutathione in plasma and bronchoalveolar lavage fluid. Bronchoalveolar lavage was performed 1-3 hours (group 2, n = 9) and 16-20 hours (group 3, n = 10) after the last dose of N-acetylcysteine and the values were compared with those in a control group receiving no N-acetylcysteine (group 1, n = 8). N-Acetylcysteine was not detected in plasma or lavage fluid. Plasma concentrations of cysteine, the main metabolite of N-acetylcysteine and a precursor of reduced glutathione, were greater in the groups receiving treatment (groups 2 and 3) than in group 1. Cysteine concentrations in lavage fluid were similar in the three groups. Concentrations of reduced glutathione were greater in both plasma and lavage fluid in group 2 than in group 1. These data suggest that N-acetylcysteine given by mouth is rapidly deacetylated to cysteine, with resulting increases in the concentrations of cysteine in plasma and of reduced glutathione in plasma and the airways, which thus temporarily increase the antioxidant capacity of the lung.
R-LIPOIC ACID / ALPHA-LIPOIC ACID
R-Lipoic Acid is normally made at low levels in the human body, where it functions primarily as an important metabolic nutrient in the conversion of pyruvic acid into acetyl coenzyme A. As such, it plays a crucial role in the metabolism of both fats and carbohydrates into energy. In addition, r-lipoic acid functions as an extremely powerful antioxidant capable of trapping many different types of free radicals in the body.
Because it is both water and fat soluble, lipoic acid is able to operate in a broader range of body tissues than most other antioxidants. Its small size allows lipoic acid to enter areas of the body not easily accessible to many other substances; this allows lipoic acid, for example, to enter the cell nucleus and prevent free-radical damage to DNA.
Because it is such a powerful antioxidant and can easily function as such in both a reduced and oxidized state, lipoic acid is able to protect other important antioxidants such as glutathione, Vitamin E, and Vitamin C. R-lipoic acid is also able to chelate heavy metals such as lead, cadmium, mercury, free iron, and free copper out of the body.
Below we provide relevant scientific abstracts from our database regarding R-Lipoic acid.
ABSTRACT 10: Alpha-Lipoic acid as a biological antioxidant.
Packer L Witt EH Tritschler HJ
In: Free Radic Biol Med (1995 Aug) 19(2):227-50
alpha-Lipoic acid, which plays an essential role in mitochondrial dehydrogenase reactions, has recently gained considerable attention as an antioxidant. Lipoate, or its reduced form, dihydrolipoate, reacts with reactive oxygen species such as superoxide radicals, hydroxyl radicals, hypochlorous acid, peroxyl radicals, and singlet oxygen. It also protects membranes by interacting with vitamin C and glutathione, which may in turn recycle vitamin E. In addition to its antioxidant activities, dihydrolipoate may exert prooxidant actions through reduction of iron. alpha-Lipoic acid administration has been shown to be beneficial in a number of oxidative stress models such as ischemia-reperfusion injury, diabetes (both alpha-lipoic acid and dihydrolipoic acid exhibit hydrophobic binding to proteins such as albumin, which can prevent glycation reactions), cataract formation, HIV activation, neurodegeneration, and radiation injury. Furthermore, lipoate can function as a redox regulator of proteins such as myoglobin, prolactin, thioredoxin and NF-kappa B transcription factor. We review the properties of lipoate in terms of (1) reactions with reactive oxygen species; (2) interactions with other antioxidants; (3) beneficial effects in oxidative stress models or clinical conditions.
Alpha-lipoic acid (α-LA) is an important antioxidant that is capable of regenerating other antioxidants, such as glutathione (GSH). However, the underlying molecular mechanism by which α-LA regenerates GSH remains poorly understood. The current study aimed to investigate whether α-LA regenerates GSH by activation of Nrf2 to alleviate cadmium-induced cytotoxicity in HepG2 cells. In the present study, we found that cadmium induced cell death by depletion of GSH through inactivation of Nrf2. Addition of α-LA to cadmium-treated cells reactivated Nrf2 and regenerated GSH through elevating the Nrf2-downstream genes γ-glutamate-cysteine ligase (γ-GCL) and GR, both of which are key enzymes for GSH synthesis. However, blocking Nrf2 with brusatol in the cells co-treated with α-LA and cadmium reduced the mRNA and the protein levels of γ-GCL and GR, thus suppressed GSH regeneration by α-LA. Our results indicated that α-LA activated Nrf2 signaling pathway, which upregulated the transcription of the enzymes for GSH synthesis and therefore GSH contents to alleviate cadmium-induced cytotoxicity in HepG2 cells.
Selenium has been shown by clinical research to be a key mineral in the body’s defenses against free radicals and has been shown to be a major factor in reducing the symptoms of HIV infections and in the prevention of tumors. Selenium is used in conjunction with glutathione to form the powerful enzyme glutathione peroxidase that is responsible for detoxification of peroxides formed during the process of aerobic metabolism in humans and other animals.
ABSTRACT 12 Serum selenium concentrations in rheumatoid arthritis.
In: Ann Rheum Dis (1991 Jun) 50(6):376-8
O’Dell JR, Lemley-Gillespie S, Palmer WR, Weaver AL, Moore GF, Klassen LW
Selenium is a trace element and an essential part of the enzyme glutathione peroxidase, which protects cells from oxidative damage. Selenium has been shown to have antiproliferative, anti-inflammatory, antiviral, and immune altering effects. Serum selenium concentrations in 101 patients with seropositive rheumatoid arthritis were found to be significantly lower than those in 29 normal, healthy controls (mean (SD) 148 (42) v 160 (25) micrograms/l) and also lower than those in eight patients with fibrositis (148 (42) v 166 (25) micrograms/l). It is speculated that serum selenium concentrations may modulate the effect of viral or other infections in subjects with the appropriate genetic background and in this way enhance the development or progression of rheumatoid arthritis.
ABSTRACT 13 Studies on selenium in top athletes.
Dragan I, Ploesteanu E, Cristea E, Mohora M, Dinu V, Troescu VS
In: Physiologie (1988 Oct-Dec) 25(4):187-90
The authors performed a controlled trial in 18 top athletes (9 weight lifters and 9 rowers, girls) in order to make evident some chronic and acute effects (antioxidant) of selenium. Nonprotein–SH (essential glutathione), lipid peroxides (MDA-malondialdehyde), glucose-6-phosphate dehydrogenases (G-6-PDH) and fructose-1,6- diphosphate aldolase in serum, have been recorded initially on basal conditions, after 3 weeks of treatment (100 micrograms/day selenium or placebo) and again after 3 weeks of treatment, also on basal conditions, when crossing over the groups (between a free interval of 10 days). In another trial we registered these parameters on basal conditions and after two hours of hard training accompanied by a per oral administration of 150 micrograms selenium (respectively placebo). The results show significant changes under selenium treatment of the peroxides, G-6-PDH and light changes, not significant of the nonprotein–SH, changes which could suggest an antioxidant effect of this element.
VITAMINS B2 and B6 IN COENZYME FORMS
Vitamin B2 as coenzyme riboflavin-5-phosphate is a key vitamin that supports the regeneration of glutathione (via glutathione reductase). Vitamin B6 as coenzyme pyridoxal-5-phosphate is a key vitamin that supports the ability of glutathione to combine with toxic substances (via glutathione transferase) in the process of eliminating them from the body. They are especially effective in their coenzyme forms which allows them to be directly utilized by the body starting in the intestinal tract.
MAGNESIUM, CALCIUM, AND ZINC
Magnesium, zinc, and calcium synergistically work with (and enhance the effects of) the other ingredients in PRO-C. Minerals are especially needed as active components of enzymes that drive metabolic activity. For example, magnesium is required in the functioning of more than 325 types of enzymes.
PRO-C™ SUPER ANTIOXIDANT FORMULA BENEFITS
HIGHLY EFFECTIVE VITAMIN C FORMULA PLUS ANTIOXIDANTS. A complete vitamin C formula, a powerful antioxidant Formula, and Nrf2 activator combined in a single advanced supplement!
POWERFUL, SYNERGISTIC FREE-RADICAL QUENCHING FORMULA. PRO-C™ components work together to quench free radicals in your body. Vitamin C enables grape seed extract to function more effectively, and conversely grape seed extract potentiates vitamin C. Green tea extract boosts ORAC (Oxygen Radical Absorbance Capacity) value.
PROVIDES SIGNIFICANT AMOUNTS OF POWERFUL NRF2 ACTIVATORS (from Grape Extract, Green Tea Extract, NAC, and R-Lipoic Acid) that stimulate the production of the body’s own protective antioxidants including superoxide dismutase, catalase, glutathione peroxidase, and heme oxygenase.
SUPERIOR, BUFFERED (NON-ACIDIC) FORM OF VITAMIN C. Mineral Ascorbates never acidify your body, keeping you pH balanced. Staying alkaline is an important element in maintaining a healthy body.
RAPID ASSIMILATION. Capsule form ensures rapid uptake and assimilation in the body. You may also empty capsule contents into water, food, or directly Into mouth, if desired. Good, mildly tart taste!
COMPOSITION OF PRO-C™ SUPER ANTIOXIDANT FORMULA
One (1) vegetarian capsule of PRO-C provides the following percentages of the Daily Value:
% Daily Value
Vitamin C (from mineral ascorbates)
BioVin® Grape Extract
Green Tea Extract
Calcium (from calcium ascorbate)
Magnesium (from magnesium ascorbate)
Zinc (from zinc ascorbate)
Vitamin B2 (from riboflavin-5′-phosphate)
Vitamin B6 (from pyridoxal-5′-phosphate)
Selenium (from l-selenomethionine)
* No established Daily Value
DIRECTIONS: As a dietary supplement take 1–3 capsules or more daily in divided doses (i.e., spread out over the day), or as recommended by a health care professional. It initially may be useful to take up to 6 capsules per day in divided doses for one week. The contents of the capsule may be emptied into juice or food, as needed.
INGREDIENTS: PRO-C™ SUPER ANTIOXIDANT FORMULA contains only the highest-quality USP grade magnesium ascorbate, USP grade calcium ascorbate, BioVin® grape extract (greater than 75% polyphenols, 93% OPC, greater than 3.5% anthocyanidins from grape pulp, skins, and seeds, and a small amount of trans resveratrol), green tea extract (95% min. polyphenols and 45% min. EGCG), l-glutathione (reduced), USP grade n-acetyl-l-cysteine, USP grade zinc ascorbate, r-(+)-lipoic acid, riboflavin-5′-phosphate, pyridoxal-5′-phosphate, l-selenomethionine, the smallest amounts of microcrystalline cellulose and silica in a vegetarian capsule.
PRO-C™ does not contain wheat, rye, oats, corn antigen, barley, gluten, soy, egg, dairy, yeast, sugar, sulfates, phosphates (other than coenzyme forms), fats, chlorides, GMOs, wax, preservatives, colorings, or artificial flavorings.
The Orthomolecular Medicine News Service (OMNS) published on June 12 “The Need for Iodine Supplementation.” We believe strongly in the need for iodine supplementation, especially given the fact that more than 90% of the US population is iodine deficient. For this reason we make available both Nascent Iodine and Lugol’s Iodine Solution 2 to our customers.
We present the full OMNS article (below), as a source of valuable information to our resellers and Creating Health Naturally readers. The factors contributing to massive-scale iodine deficiency remain virtually unchanged over decades. This has led to a greater need for educating health professionals and individuals about the critical importance of iodine supplementation.
(OMNS, June 12, 2017) Feeling tired, having low energy or depression, gaining weight, memory problems, having dry skin, dry mouth, or immune system issues? There is good chance your body needs iodine supplementation. Why iodine? Because this essential to human health element has been singled out as dangerous, for several obscure reasons, and it has been gradually eliminated from our diet, and even worse, replaced by its antagonist, bromine. This trend has been termed, iodophobia (1). It is a cause of widely occurring hypothyroidism in many developed countries.
Iodine: How Much?
Iodine deficiency is associated with (2, 3, 4):
Fibrocystic breast disease leading to breast cancer and stomach cancer
Goiter (enlarged thyroid)
Mental issues from reduced alertness, lowered IQ, autism to cretinism, lack of iodine for the fetus leads to cretinism, and in milder cases to autism and ADHD
Slow metabolism, leading to tiredness, sluggishness, fatigue, apathy, depression, and insomnia
Inability to produce saliva, dry skin, and lack of sweating
Lack of optimal detoxification, especially of bromides, fluorides, and heavy metals
Sensitivity to temperature changes, and cold hands and feet
Muscle pain, fibrosis, and fibromyalgia
Erectile dysfunction, infertility and miscarriages, and low sex drive
High blood pressure, and increased incidence of heart attacks and strokes
The Food and Agriculture Organization (FAO) of the United Nations has published probable safe upper limits for dietary intake of iodine (5). They range from 150 micrograms (mcg) per kilogram (kg) per day in newborn infants to 30mcg/kg/day in adults. That is 2 milligrams (2,000 micrograms) daily for a 146-pound adult. The safe upper limit is higher during pregnancy and lactation (40 mcg/kg/day).
Treatments for Hypothyroidism
The simplest method to deal with an underactive thyroid is proper supplementation with iodine, called orthoiodosupplementation. If the thyroid is damaged, then supplementation with thyroid hormones, thyroxine (T4) and triiodothyronine (T3, the main biologically active hormone) may be necessary. Supplementation (6). with these hormones should be done under close supervision of a medical professional. However, supplementation with inorganic iodine is generally much safer, as the body “knows” how much T4 and T3 need to make. There are also drugs that change physiology of iodine metabolism, but this subject is beyond the scope of this article. Pharmaceutical companies pressure doctors to avoid inexpensive orthoiodosupplementation, so you won’t likely get a prescription for inexpensive Lugol’s solution from a mainstream practitioner.
One caveat to supplementation with iodine is the autoimmune illness called Hashimoto’s disease, or chronic lymphocytic thyroiditis, which is one of the potential causes of hypothyroidism. Unfortunately, when hypothyroidism is diagnosed, the possibility that Hashimoto’s disease underlies this condition has not always been properly tested. Therefore, Hashimoto’s disease has often been misdiagnosed. Doctors usually treat this condition with hormone replacement therapy, and some believe that excessive iodine intake may trigger it in susceptible people (7). Always ask your doctor if iodine supplements are right for you.
History of Iodine Usage and “Iodophobia”
This subject has been covered in detail by Dr. Guy E. Abraham (8,9,10). The iodine element was discovered in 1811 by B. Courtois. In 1850–1853 A. Chatin noted that goiter and cretinism are rare in geological zones rich in iodine and frequent where iodine is in short supply, and that goiter can be prevented by iodine supplementation. In 1895 E. Baumann proposed that iodine is the active element in the thyroid gland.
By the time Bauman identified large concentrations of iodine in the thyroid gland in 1895, pharmaceutical and apothecary preparations containing iodine, excluding thyroid extracts, were widely used as a panacea.
To quote Kelley: (11) “The variety of diseases for which iodine was prescribed in the early years is astonishing – paralysis, chorea, scrofula, lacrimal fistula, deafness, distortions of the spine, hip-joint disease, syphilis, acute inflammation, gout, gangrene, dropsy, carbuncles, whitlow, chilblains, burns, scalds, lupus, croup, catarrh, asthma, ulcers, and bronchitis – to mention only a few. Indeed, tincture of iodine, iodoform, or one of the iodides, was applied to almost every case that resisted the ordinary routine of practice; and between 1820 and 1840 there appeared a remarkable series of essays and monographs testifying to the extraordinary benefits to be achieved by this new and potent remedy.”
Unfortunately, these monographs have virtually disappeared from US medical libraries. In the mid-1800s, iodine treatments of some diseases called for ingestion of gram (1,000 mg) amounts per day. However, most treatments were from 5 to 50 mg daily. The recommended daily amount of iodine by Dr. G. E. Abraham is 0.1-0.3 ml Lugol containing 12.5-37.5 mg elemental iodine. This is the amount of iodine needed for whole body sufficiency, based on a recently reported iodine/iodide-loading test (12). Thyroid gland sufficiency for iodide is achieved with a lower dose.
The first iodophobic authority emerged in early 1900s. Prof. T. Kochler reported that he suffered from overactive thyroid following ingestion of iodide (just a single individual case, not a statistical research study!) Despite this, the number of applications grew. In an International Index published in 1956, and devoted exclusively to iodine pharmaceuticals, no less than 1,700 approved iodine-containing products were listed. In 1948 Wolff and Chaikoff published that a serum inorganic iodide level at a concentration of 1 µM blocks (one micromolar) the synthesis of thyroid hormones, resulting in hypothyroidism and goiter in rats. But this conclusion was erroneous as they even did not measure thyroid hormones in the rats studied, and of course, hypothyroidism and goiter were not observed in those rats. Many organic forms of iodinated drugs were quite poisonous. Unfortunately, medical establishment did not make a distinction between organic and inorganic forms of iodine, and iodophobia became more popular.
Decades ago, iodine was added to bread so that one slice contained 150 mcg of iodine (the current recommended daily allowance). In the 1980s, bromine replaced iodine in bread. Since bromide is an antagonist to iodine (it is goitrogenic), it worsened iodine deficiency in the US. Moreover, a big push to remove salt from our diet (the only grocery item still supplemented with iodine) exacerbated the problem. The only developed nation that resisted iodophobia is Japan, statistically the healthiest and longest living nation on the planet. Their average daily consumption of iodine is around 5 mg, with various reports ranging from 1 mg to 18 mg. In a study of reported daily iodine intake versus total number of clinical symptoms, an intake of approximately 1 mg per day correlated with the lowest number of reported symptoms, that is, the highest level of health (13). Recent popularization of bromides in our food supplies likely increased this amount.
According to Dr. Abraham, (14) “proper amounts of iodine in the food supply should be considered one of a nation’s greatest assets. Removing iodine from the food supply is a major mistake. Supplying a daily intake of iodine sufficient for the whole body (100-400 times the RDA) gives protection against goitrogens and radioactive iodine/iodide fallout; improves immune functions, resulting in an adequate defense system against infection; decreases singlet oxygen formation which is the major cause of oxidative damage to DNA and macromolecules, resulting in an anticarcinogenic effect in every organ; results in a detoxifying effect by increasing urinary excretion of the toxic metals lead, mercury, cadmium, and aluminum, as well as the goitrogens fluoride and bromide; normalizes hormone receptor functions resulting in improved response to thyroid hormones both endogenous and exogenous; and results in better control of blood sugar in diabetic patients; stabilizes cardiac rhythm, obviating the need for the toxic sustained release form of iodine, amiodarone; and normalizes blood pressure without medication in hypertensive patients. Iodine deficiency is the major cause of cognitive impairment, worldwide.”
The Iodine-Cancer Connection
The body requires iodine to metabolize both omega-3 and omega-6 fatty acids. A substance called delta-iodolactone, a derivative of arachidonic acid, which is produced in the thyroid gland and breast tissue, prostate, colon, and the nervous system, is a regulator of a process called cellular apoptosis (“cell death”). Ascorbic acid is required to stimulate intracellular hydrogen peroxide synthesis that, in turn, provides the energy to make iodine free radicals necessary for this reaction. When the level of delta-iodolactone is high enough, the process of apoptosis can then kill cancer cells. (15)
Unfortunately, the recommended daily allowance (RDA) for iodine — about 150 mcg per day — will not allow delta-iodolactone to be efficiently formed in the thyroid gland. The thyroid requires higher iodine concentrations to efficiently produce it. Researchers have found that 100 times the RDA amount of iodine is optimal to produce delta-iodolactone. That equates to taking about 15 mg of iodine per day (15,16). These findings are important because they imply that there are some biochemical reactions that require much larger amounts of iodine than the current RDA. The mechanism by which delta-iodolactone induces cell death may be an important pathway for curing some types of cancer.
Forms of Iodine
Inorganic iodine exists in 6 oxidative states, from -1 to +7. The most reduced form (with most electrons) is iodide (I–); an example is potassium iodide. The diatomic form of elemental iodine I2, has no electrical charge. Monoatomic iodine also has no electrical charge, but is unstable and highly reactive (free radical, labeled as an I with a dot, I* ). It can be produced by exposing I2 to ultraviolet light. Electric and magnetic fields won’t do it, as is sometimes incorrectly suggested. More oxidized forms of iodine are: hypoiodite (I+1), iodite (I+3), iodate (I+5), and periodate (I+7). The body’s metabolism may convert (reduce) these forms to biochemically available iodide, but at the cost of depleting its antioxidants. All forms of positively charged iodine are relatively poisonous, with established lethal doses (LD50) in the range of 35 to 2100 mg/kg. Elemental iodine (I2) and iodides (I–) are non-poisonous. However, a bad “antiseptic” non-culinary taste of iodine (I2) suggests to our senses that this is not so good choice for supplementation.
Despite that adverse taste, almost all the research on iodine supplementation has been done using Lugol’s Solution (17). The original solution is called 5% Lugol’s Iodine, but in reality it consists of 12.5% iodide/iodine or (I–/[I3]–) ions. Two drops of Lugol’s Solution (0.1 ml) contain 12.5 mg iodine/iodide mix. Iodine tablets that are a solid form of Lugol’s solution, were created to mask the taste and make the doses more precise for dietary supplementation.
I should mention a few points about Edgar Cayce’s atomidine. This famous visionary wrote several articles about the best form of iodine supplement (18). Some claim that this was iodine trichloride, but that cannot be true as this compound is toxic by ingestion and damaging to mucous membranes. It decomposes to ICl and poisonous gas Cl2 at 77 degrees C and also in water at room temperature (19). Most likely Cayce’s atomidine was simply a 1% iodine solution (I2) in 95% ethanol. I am surprised that there are educated people, even medical doctors who claim that “elemental monoatomic iodine” preparations (Atomidine, Nascent Iodine etc.) are the best forms of iodine supplements. May be it has something to do with efficient marketing? Elemental Iodine (I2) is soluble in glycerin. Replacement of ethanol with glycerol indeed makes these supplements more consumption-friendly, so they are sold by some vendors as superior products to Cayce’s ethanol-formulated one. Personally, I think glycerol-based I2 supplements are inferior to iodides; however, they are excellent antiseptics.
To defend the validity of Cayce’s vision, in thyroid, I– ion and amino acid tyrosine react through a short intermediate step by forming monoatomic I* free radical (selenium and hydrogen peroxide are involved) to make monoiodotyrosine. Diiodotyrosine is formed analogical way, and finally, two of these molecules combine to produce thyroxine. All those steps are carried by the enzyme thyroid peroxidase, which is normally attached to the protein thyroglobulin. So, yes, monoatomic iodine I* exists in human bodies, and it directly reacts with tyrosine, but no, it wouldn’t be healthy to consume iodine free radicals as their high reactivity would prevent safe transport throughout the body.
In the mid-1930s the thyroid hormone thyroxine became available on the market. This was a blessing for people who had damaged their thyroid. Unfortunately, doctors started to prescribe this hormone to just about anybody with hypothyroidism, thinking that they can control better thyroid hormone levels than our bodies can. And, the “iodine is iodine, no matter what form” mentality became a dangerous trend, because most medical professionals do not fully appreciate the difference between the raw nutrient (iodine) and its product (hormone).
The pharmaceutical industry came up with lots of organic forms of iodine (NB: organic, meaning that iodine is bound to a carbon-atom-containing molecule and NOT meaning it’s grown in a pesticide-free environment), all relatively toxic and certainly not to be used without strict medical supervision. Only inorganic forms of iodine, I– and I2, are safe for supplementation (20,21). Further, high doses of these supplements should still be supervised by your doctor.
Iodine plays critical role in human metabolism. Many researchers believe the RDA value of 150 mcg for iodine is too low, especially when this element is commonly substituted with competing element bromine. Therefore, the main use of iodine in dietary supplementation is to enable optimal thyroid function. There are a number of medical conditions where iodine is either essential or helpful. For best results, iodine/iodide should be supplemented with selenium, magnesium, copper (there is usually enough of it in tap water as copper is widely used in plumbing), vitamin B2 (riboflavin) and B3 (niacin). Ask your doctor before taking any iodine supplements, especially if you are on medications.
Elemental iodine (I2) is antibacterial and antifungal, so iodine or iodine/iodide solutions are commonly used topically to sterilize wounds, or internally to fight infections, such as vaginitis and sore throat, and also to sanitize drinking water. Because iodine is antibacterial, drinking it may cause friendly bacterial flora to suffer and result in diarrhea and stomach cramps (the same applies to Lugol’s solution, but to a lesser extent as it contains iodides as well).
Ingestion of iodides prevents the incorporation of destructive radioactive iodine into the body (mainly by the thyroid) in case of nuclear accidents. It also may help flushing already incorporated radioactive iodine from the thyroid, although too much iodine inhibits secretion of T4/T3 from the gland.
Overdosing any of the iodine supplements can lead to swollen salivary glands, metallic aftertaste and skin rash and itching (that are usually due to rapid process of detoxification from heavy metals fluorides and bromides), faster heartbeat or palpitations and diarrhea. When supplementation is stopped, these symptoms will usually disappear quickly, often within one day. Iodine stabilizes thyroid hormone production, so it is an adaptogen, but in rare cases, such as acquired allergy to iodine (Hashimoto’s disease), it may actually misbalance it. In some cases, iodine supplementation can cause hypothyroidism, so it’s important to get checked by your doctor to make sure that your thyroid function is not worsened by supplementation. Some authors advising caution are Alan Christianson (22), Jeffrey Dach, (23) and Alan Gaby (24). Testing of levels of thyroid hormones along with testing and supplementation of mineral nutrients such as selenium, zinc, copper, magnesium calcium, and other trace minerals may prevent problems in cases where high doses of iodine/iodide might tend to cause Hashimoto’s disease. (23)
Inorganic Iodine Availability
The most common form of iodine supplement is Lugol’s solution (17). The original solution contains 5% of iodine and 10% iodide. Solid pill forms of Lugol’s solution are sold under several brand names. Potassium iodide (KI), my favorite iodine supplement, is available as tablets as well. Various products with kelp or other seaweed extracts contain iodides as well. Check the label when you buy as some of them are very diluted.
It is difficult to find inexpensive elemental iodine (I2) solution in alcohol. You can buy iodine crystals online and make the proper solution by yourself very easily (using either alcohol or glycerol). The monoatomic iodine concept is simply a marketing gimmick that has been created to inflate the price several fold. Note that if the monoatomic claims were really true, few would really want to drink free radicals, the only monoatomic form that exists. Iodine free radicals are not transported freely in our bodies because they are too reactive. Elemental iodine preparations, including iodine dissolved in glycerol, may be helpful products for external antiseptic use rather than a supplement.
Another form of iodine supplement includes a mixture of algae and thyroid extract in glycerin, water and ethanol. This is likely not harmful because it contains T3 and T4 only in very small amounts, and the recommended serving size is also small. Other complex formulae that contain elemental iodine are a useful antiseptic, but not a good supplement. Iodine trichloride should be avoided as a supplement because it is too toxic.(19)
The established RDA allowance for iodine (150 mcg/day) is inadequate for many individuals. In order to maintain optimum health, adults need 2-5 mg of iodide daily. Actually, this is in line with the upper safe limit of dietary intake of iodine established by FAO (30 mcg/kg/day). In case of a dysfunctional thyroid or other illnesses, such as fibrocystic breast disease or cancer, 15-50 mg daily may be needed. Ask your doctor about the alternatives to hormone therapy or taking iodine-containing organic drugs, because inexpensive orthoiodosupplementation would usually not be his/her first choice.
The best and safest form of iodine supplementation for a healthy adult is iodide. Iodides are naturally produced in larger quantities by various seaweeds.
Please consult your doctor about iodine supplementation, as in your particular case it may be contraindicated.
Today HPDI launches a new product: pH Adjust. The new formula wascreated by Dr. Hank Liers, PhD. As its name implies, its primary application is to help balance pH levels in the body. That is, to support the creation of alkaline conditions — or alkalinization.
Because pH Adjust alkalinizes the body, it thereby may effectively counteract overly acidic conditions (acidosis), including acidic conditions in the digestive tract, blood, kidneys, and other organ systems.
Our newest product pH ADJUST
Given the fact that acidosis—including chronic, low-grade acidosis—is common among individuals living in industrialized nations consuming high-levels of processed foods and other acid-forming foods, pH Adjust represents a simple, yet powerful means for achieving a healthy acid-base balance in the body.
HPDI specializes in the formulation of nutritional supplements, including vitamin formulas such as multivitamins and other foundational supplements, advanced antioxidant formulas, high-RNA superfoods, and various mineral products, including magnesium. pH Adjust may be considered a mineral product. Yet, it is different than any other HPDI formula.
That is, pH Adjust is not primarily formulated to provide nutrients to meet nutritional needs. Rather, the formula supports optimal health by facilitating improved acid-alkaline balance in the body. It may be used to effectively neutralize acidic conditions, and help counteract the tendency toward acidosis that persists among many individuals.
THE IMPORTANCE OF pH BALANCE
Health experts know that pH balance is extremely important, and that acidosis in the body contributes to various states of less than optimal health. It is known that acidic conditions can lead to adverse effects in many bodily systems, including the circulatory system, immune system, skeletal system, excretory system, muscular system, and reproductive system.
Chemically, pH stands for hydrogen ion concentration. The pH scale runs from 7 to 14, and pH 7 is considered neutral. A pH value of less than 7 is considered acidic whereas a pH value of greater than 7 is considered basic or alkaline. In the body, the ideal pH is somewhat alkaline: 7.30 to 7.5.
For therapeutic purposes, individuals can for short periods of time (from a few days to a couple weeks) raise their pH levels to 8.0. That is, short-term increases in pH (to 8.0) can be useful for rapidly changing conditions in the body from acidic to basic (alkaline).
DIET AND pH (ACID-BASE) BALANCE
Herman Aihara (author of Acid & Alkaline) and others have contributed to our understanding of acid and alkaline states in the body, and the roles played by foods in creating either conditions of acidity or alkalinity. In general, protein foods are “acid-forming” foods whereas most vegetables are “alkaline-forming” foods. A table of acid and alkaline forming foods are on our website at Effect of Food on Body Chemistry.
Thus, proteins (containing more nitrogen) tend to form acids in the body whether or not they themselves are acid, and vegetables (containing more potassium) tend for form bases in the body whether or not they themselves are basic. This fact supports the importance of vegetables in the diet not only for nutrients, but also as a means for ensuring acid-base balance.
An excellent food that provides a high potassium content is Dr. Hank’s Vegetable Soup. This soup tastes great and can help to keep a healthy acid-base balance in the body.
An excellent article published in the American Journal of Clinical Nutrition in 1998 looked at the key factors that determine acid-base balance in the body. Their conclusion was: “In summary, the results of this study indicate that in normal humans eating ordinary whole-food diets, the major determinants of differences in NEAP rate (net endogenous acid production) among subjects are differences in the protein and potassium content of the diet and that the absolute rate of net endogenous acid production for a given diet can be predicted simply from knowledge of the diet’s protein and potassium content.”
Potassium-containing foods provide the body with potassium that it can use to create alkaline conditions. Sodium can also support alkaline conditions in the body. In fact, potassium and sodium work together in the sodium-potassium pump that pumps sodium ions out of cells and potassium ions into cells using ATP, and that performs many essential functions, including nutrient transport, cell-volume regulation, and nerve conduction.
Danish chemist Jens Christian Skou shared the 1997 Nobel Prize in Chemistry for having discovered this pump, i.e., the ion-transporting enzyme, Na+, K+ -ATPase in 1957 while at the University of Aarhus in Denmark.
It is notable that most individuals in Western societies obtain more than sufficient sodium and often less than sufficient potassium. Excessive sodium intake is associated with adverse effects on cardiovascular health.
In an interview with Dr. Richard Passwater in 2001, Dr. Richard Moore said: “When I looked at all the published data for both potassium and sodium in the diet—or in the urine which reflects the diet-and then looked at the incidence of hypertension, I could see that, as the K Factor (ratio of potassium to sodium in the diet) got above one or two, there was significantly less hypertension (high blood pressure). Actually a diet with a K Factor of three or above is not bad, but, for practical purposes, I think a K Factor above four is a better goal. Of course, even higher than that would be better in terms of general health. I say this based upon the fact that our ancestors had a K Factor of about 16 to 1 and we evolved having a K Factor something like that.”
Based upon this information, we have chosen a 3:1 ratio of potassium to sodium in the pH Adjust formula so that it consistent with a heart-healthy diet.
MEASURING pH LEVELS
The best way to measure pH levels is to use litmus paper. HPDI offers litmus paper in rolls (Hydrion brand) for this purpose providing about 100 tests per roll. You can test salivary or urinary pH. In order to test salivary pH, simply use a small strip of pH paper to dip into a small amount of saliva. Advantages of pH paper include rapid results, ease of use, and cost effectiveness.
Using pH paper is a fast, easy means to measure pH accurately
The color of the litmus paper indicates the pH level in saliva. Most litmus paper comes with an indicator chart showing colors corresponding to various pH levels. Alkaline states will generally produce a dark green, blue or purple color (most basic). Acidic states will range from yellow (most acidic) to light green.
Salivary pH and urinary pH are significantly affected by recent food consumption and other factors, so it it best to test pH hours after meals. We prefer to measure urinary pH since results are more consistent. Measuring urinary pH is a simple as placing a few drops of urine on the paper or dipping the paper into a sample cup.
It is best to measure your pH in the morning before consuming foods or drinks. Salivary and urinary pH are affected by recent food consumption, so re-test several hours after eating, and additionally throughout the day.
A consistent pH measurement of less than 7.0 indicates that you are too acidic (values less than 6.2 show extreme acidity). This indicates that you should consume more alkaline forming foods and/or take pH Adjust. A single dose of pH Adjust can change conditions in the body from acidic to alkaline within a few hours.
MINERALS: POTASSIUM, MAGNESIUM, AND SODIUM
As we mentioned, pH Adjust is not primarily formulated to provide minerals or other essential nutrients. HPDI has other products (like multivitamins and single-nutrient formulas) for that purpose.
However, pH Adjustis a mineral providing formula. That is, it provides potassium (in the forms of bicarbonate and glycinate), magnesium (in the form of carbonate), and sodium (in the form of bicarbonate).
And while the levels of potassium (141.6 mg or 4% daily value) and sodium (47.8 mg or 2% daily value) per dose of pH Adjust are relatively small, the level of magnesium is significant (105 mg or 26.3% daily value).
Moreover, the levels of these minerals in pH Adjust are balanced, so that sufficient potassium is obtained relative to sodium, and that sodium remains low in the formula (for reasons previously considered).
Note that the amounts of minerals listed (above) are obtained per dose, so additional doses will correspondingly increase the amounts of minerals. However, multiple doses should not significantly increase sodium levels. For example, more sodium may be obtained from a single salty snack than one or two doses of pH Adjust.
Supplements Facts table from pH Adjust product label.
One dose is 1/4 teaspoon. For extremely acidic conditions, you can take 4–10 doses per day, depending on the level of acidity and using pH paper as a guide to ensure that pH levels remain balanced. That is, the goal is to balance pH and to not become too alkaline (a condition of alkalosis may occur above pH 8.2).
INFORMATION FROM THE PRODUCT PAGE (INTEGRATEDHEALTH.COM)
pHADJUST may be used to increase salivary and urinary pH; counteract overly acidic conditions in the digestive tract, blood, and kidneys; and to supplement the body with the minerals potassium, magnesium, and sodium. The product contains (in powder form) potassium bicarbonate, magnesium carbonate, potassium glycinate, and sodium bicarbonate. Each serving (about ¼ tsp) contains about 300 mg of bicarbonate, 260 mg of carbonate, 142 mg of potassium, 105 mg of magnesium, 48 mg of sodium, and 100 mg of glycine.
NUTRITIONAL CONSIDERATIONS AND APPLICATIONS
The minerals potassium, sodium, and magnesium are key substances that are involved in many important functions in the body. When combined in bicarbonates (potassium & sodium), carbonates (magnesium), and glycinate (potassium) these chemicals can help to adjust and balance pH that are crucial to body function.
The processed food diets with a high protein content consumed by many people in the US and elsewhere produce conditions in the body of acidity. This in turn leads to decreased oxygenation of our cells and a greater use of anaerobic processes in metabolism. This, in turn, leads in inadequate ATP (energy) production and the presence of unwelcome anaerobic cells and organisms.
Bicarbonate is a major element in our body. Secreted by the stomach, it is necessary for digestion. When ingested, for example, with mineral water, it helps buffer lactic acid generated during exercise and additionally reduces the acidity of dietary components. Additionally, it has a prevention effect on dental cavities. Each ¼ tsp of pH ADJUST contains about 300 mg of bicarbonate.
Bicarbonate is present in all body fluids and organs and plays a major role in the acid-base balances in the human body. The first organ where food, beverages and water stay in our body is the stomach. The mucus membrane of the human stomach has 30 million glands which produce gastric juice containing not only acids, but also bicarbonate.
The flow of bicarbonate in the stomach amounts from 24.4 mg/hr for a basal output to 73.2 mg/hr for a maximal output. Thus at least 500 mg of bicarbonate is secreted daily in our stomach. This rate of gastric bicarbonate secretion is 2-10% of the maximum rate of acid secretion. In the stomach, bicarbonate participates in a mucus-bicarbonate barrier regarded as the first line of the protective and repair mechanisms. On neutralization by acid, carbon dioxide is produced from bicarbonate.
Effects of ingested bicarbonate: For digestion, bicarbonate is naturally produced by the gastric membrane in the stomach. This production will be low in alkaline conditions and will rise in response to acidity. In healthy individuals this adaptive mechanism will control the pH perfectly. To modify this pH with exogenous doses of bicarbonate, some clinical experiments have been conducted with sodium bicarbonate loads as high as 6 g. Only a transient effect on pH has been obtained. It is quite possible that bicarbonate in water may play a buffering role in the case of people sensitive to gastric acidity. Thus bicarbonate may be helpful for digestion.
The most important effect of bicarbonate ingestion is the change in acid-base balance as well as blood pH and bicarbonate concentration in biological fluids. It has been studied particularly in physically active people. Among the types of acid produced, lactic acid generated during exercise is buffered by bicarbonate. In a study on sports, a dose of 0.3 g per kg of body weight of sodium bicarbonate was given (15.25 g bicarbonate for a man of 70 kg) to subjects before performing 30 minutes cycling. While blood pH was increased and then maintained constant with this bicarbonate load due to the changes in blood bicarbonate concentrations, increased acidity and decreased bicarbonate blood concentration were observed in controlled subjects.
Prevention of renal stones: Bicarbonate also reduces the acidity of dietary components such as proteins. As an example, adding sodium or potassium bicarbonate to subjects on a high protein diet known to acidify urine and leading to hypercalciuria (high level of calcium in urine) has been shown to greatly reduce calcium urinary excretion. The effect has been observed with 5.5 g of bicarbonate supplement received daily for two weeks. A recent study highlights that a bicarbonate-rich mineral water could be useful in the prevention of the recurrence of calcium oxalate and uric acid renal stones.
Controls water absorption: many oral hydration solutions contain bicarbonate showing the usefulness of bicarbonate to control water absorption in patients at risk of dehydration.
Maintains blood pressure: Sodium intake is restricted in patients with hypertension, but it is demonstrated that the accompanying anion, such as bicarbonate, plays an important role. It is now well established that sodium bicarbonate does not raise blood pressure to the same extent as do the corresponding amounts of sodium chloride.
Decreases dental plaque: Bicarbonate has been shown to decrease dental plaque acidity induced by sucrose and its buffering capacity is important to prevent dental cavities. Other studies have shown that bicarbonate inhibits plaque formation on teeth and, in addition, increases calcium uptake by dental enamel.
pH ADJUST contains about 260 mg of carbonate (and 105 mg of Mg) in the form of magnesium carbonate. Magnesium carbonate is used as an antacid that gets converted to Magnesium Chloride (MgCl) and CO2 by stomach acid. MgCl is a well absorbed form of magnesium.
The functions of the key minerals in pH ADJUST are described below. Each serving (about ¼ tsp) of pH ADJUST contains 142 mg of potassium, 105 mg of magnesium, and 48 mg of sodium.
Resting cellular-membrane potential and the propagation of action potentials in neuronal, muscular, and cardiac tissue. Due to the electrostatic and chemical properties, K+ions are larger than Na+ions, and ion channels and pumps in cell membranes can differentiate between the two ions, actively pumping or passively passing one of the two ions while blocking the other.
Supports hormone secretion and action
Improves vascular tone
Regulates systemic blood pressure
Increases gastrointestinal motility
Required for acid–base homeostasis
Supports glucose and insulin metabolism
Plays role in mineralocorticoid action
Supports renal concentrating ability
Regulates fluid and electrolyte balance
Magnesium levels influence many physiological processes and functions. These include:
Increases energy by greater production of ATP (adenosine triphosphate) in cells
Supports production and function of over 300 enzyme systems in the body
Relaxes muscles / reduces muscle tension
Boosts vitality, endurance, and strength
Improves cardiovascular / heart health (relaxes cardiac muscle)
Relieves pain, including chronic pain
Ideal for arthritis / fibromyalgia / joint pain
Improves health of skin and mucous membranes
Eases headaches and migraine headaches
In sports medicine — replenishes Mg levels for energy (combats fatigue, and
soothes pain and sore muscles)
Improves mood and reduces stress
Increases memory and cognitive functions
Boosts immune system
Improves assimilation of calcium / builds stronger bones
INGREDIENTS: Potassium bicarbonate, magnesium carbonate, potassium glycinate, and sodium bicarbonate.
DIRECTIONS: As a dietary supplement, take ¼ tsp in 4–8 ounces of purified water preferably away from food, or as directed by a health care professional.
For extremely acidic conditions (pH consistently less than 6.2), try 4–10 doses per day, depending on acidity level. you may take multiple 1/4 tsp doses at once—we ourselves often take 1 tsp in a single dose. Use pH paper to ensure pH levels remain balanced, and do not become too alkaline (alkalosis may occur above pH 8.2).
DOES NOT CONTAIN: wheat, gluten, rye, barley, oats, corn, yeast, egg, dairy, soy, GMOs, sugar, wax, artificial preservatives, flavorings, or colorings.