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RELIEF Rx™ REMEDY FOR MUSCLES, SKIN, AND JOINTS

Dr. Hank Liers, PhD Relief Rx™ pain sore musclesOne of our suppliers recently sent me a new product sample called Relief Rx™ to evaluate. The product is a topically-applied fast-acting “Aloe vera relief gel” for sore muscles, back, joints, and skin.

ReliefRx

After I applied the gel to painful or sore spots on my body, my pain and soreness was relieved in a short time — 15 minutes or less! I was quite impressed, needless to say. The gel has no odor and after it dries, it leaves no messy oils etc. on your skin—unlike many other topical skin formulas.

Because Relief Rx™ is a new product there are no prior sales data. However, our supplier also sent product samples to many other people who agreed to try it. The results experienced by the testers were nothing short of amazing — see some of their testimonials below.

 

 

RELIEF Rx™ INGREDIENTS

Aloe vera, a primary ingredient in Relief Rx™

Aloe vera is a primary ingredient in Relief Rx™

Aloe vera (organic)

The Egyptians called Aloe vera the “plant of immortality.” Aloe has been cultivated for centuries by indigenous people from Africa to Asia, and it is revered around the world by herbalists. As such, it may be the ultimate resource nature has provided for natural health.

The aloe extract in Relief Rx™ is carefully prepared with 100% organically grown plants, then compounded with a proprietary process to provide highly bioavailable constituents, such as acemannan and a full-spectrum of natural polysaccharides. Some of the known helpful effects of acemannan include:

  1. Helps cells to be more resistant to viruses and pathogenic bacteria.
  2. Improves overall cellular metabolism and functioning.
  3. Promotes healthy inflammation response.
  4. Provides critical lubrication of joints.
  5. Reduces pain.
  6. Improves vascular flow.
  7. Reduces scarring.
  8. Improves healthy macrophage activity.
  9. Increases the body’s own production of interferon, interleukins.
  10. Increases the number and activity of killer T-cell and increase monocyte activity.
  11. Fights fungal infections, such as: Athlete’s foot, Ringworm, Pruritus anivalvae, Balnea, Essential Pruritus, and Vaginal yeast infections/
  12. Helps athletic injuries such as: Muscle cramps, Sprains, Strains, Bruises, Swelling, Soreness, Tendonitis, and Bursitis.
  13. Helps with harmful organisms.
  14. Speeds wound healing..
  15. Anti-aging properties. Stimulate fibroblasts to release collagen and elastin to make new tissue.

You will feel the quality of the Aloe vera at work with every application.

Hemp

Hemp

Hemp Oil:
The hemp oil in Relief Rx™ is extracted from the flowers and leaves of the revered hemp plant. It is especially rich in bioactive molecules (without any psychotropic effects or side effects) and has gained worldwide recognition as a natural and potent therapeutic nutrient.

Select hemp oil molecules interact with our inherent endogenous cannabinoid (endocannabinoid) system to carry out beneficial and protective physiological reactions. First discovered in the late 1980s, the endocannabinoid system supports the body’s complex regulatory mechanisms including mood, sleep, appetite, hormones, pain, and immune response.

Relief Rx™ utilizes an advanced proprietary science that greatly enhances the efficacy of hemp oil to achieve results that are unequaled by conventional products.

White Willow Bark Extract (Salix alba)

White Willow Bark Extract (Salix alba)

White Willow Bark Extract (Salix alba):
A native of Europe and Asia, the name of this deciduous tree comes from the lightly colored undersides of its slender leaves. Willow may in fact be one of the oldest remedies, used in ancient Egypt and China as early as 500 BCE.

Healers applying skin and beauty treatments understood that willow bark was an important ingredient in the support of natural health. Careful processing ensures that the willow extract in Relief Rx™ contains the highest purity of ingredients. Benefits of using white willow bark extract include:

  • Anti-aging: A 2010 study reported that salicin can help reduce the appearance of skin aging. Researchers applied a serum product containing 0.5 percent salicin on the faces of women aged 35 to 70, every day for 12 weeks. Results showed improvements in the appearance of wrinkles, pore size, radiance, and overall appearance after only one week.

  • Helps cleanse oily skin: Willow bark extract naturally exfoliates skin and clears pores to give skin a clearer, healthier appearance.
  • Smooths the appearance of fine lines and wrinkles: The same exfoliating action that reduces clogged pores also helps smooth the look of fine line and wrinkles. Willow bark is a source of natural hydroxy acids that gently exfoliate. The result is smoother, softer skin.
  • Antioxidants: Like most plant extracts, willow bark contains flavonoids and tannins—powerful antioxidants that help protect skin from environmental stressors.
Relief Rx™ contains important trace minerals

Relief Rx™ contains important trace minerals

Ionic Trace Minerals Blend:
There is a great deal of evidence that the healthy function of the body is strongly influenced by electrical impulses. That is, our bodies use electrical impulse pathways, and electrolytes and ions are the conductors of these currents maintaining a smoothly running body. Ions provide the necessary charge of both positive and negative molecules that keep the electrical component of the human battery “charged” and working in top form.

The human skin is the largest organ of the body and is highly involved in the detoxification and maintenance processes of health. Skin not only excretes and eliminates toxins; it also has a tremendous capacity to absorb health supportive substances.

Clinical researchers have continued to document the clinical findings that have been observed for decades when it comes to the healing properties of topical minerals. Many of the studies on therapeutic baths have used minerals from the Dead Sea as well as the Great Salt Lake. Of particular interest are the powerful effects of these salts that exhibit favorable effects in inflammatory disease.

In one study, 103 arthritic patients received various bath treatments with ionic trace minerals. The study showed impressive results and those with the greatest physical limitation had the most pronounced improvement. A large percentage of the patients reported having less pain, improved mobility and were able to decrease analgesic use. In a different double-blind study, the use of warm mineral baths demonstrated a lasting effect for patients suffering from degenerative arthritis.

In a clinical trial conducted by a leading research university in Germany, patients with atopic (eczema) skin disorders immersed their arms in a mineral rich bath. The participants immersed one arm in tap water the other in the therapeutic mineral rich bath. The findings showed that skin hydration was improved and skin roughness and inflammation was reduced when immersed in the mineral rich water.

RELIEF Rx™ USAGE

Direction for use:
Apply a generous amount of gel to stressed muscles and joints as needed for soothing harmonious comfort, creating a moist surface. Allow the moisture to absorb naturally into the skin and air dry on its own. Keep tightly sealed and away from children. For external use only.

Ingredients:
Purified water, Glucomannan, Organic Aloe vera, Ionic Trace Elements Blend, Hemp Oil, White Willow Bark Extract, Citric Acid, Potassium Sorbate, Sodium Benzoate.

RELIEF Rx™ TESTIMONIALS

Relief Rx™ is a new product with no prior sales data. The product was sent out to a number of people who agreed to try it. The results obtained were amazing as shown in the testimonials given below. Personally, we can confirm that the product works extremely well for a variety of muscle and joint issues – usually providing sustained relief within a short time after applying the gel to the skin.

1. Ole G., Topanga, California: “I am an 88-year old retired mechanical engineer with multiple knee, hip and upper back chronic discomfort, that is UNTIL I FOUND Relief Rx. All of it was gone in a matter of minutes. I now use this gel only when I over exert myself during yard work and gardening. I love this product…!!”

2. Paul G.: “In all of my 35+ years in the fitness facility business I never saw a relief product that works as good as Relief Rx™. This stuff is on the verge of being miraculous……truly amazing”

3. Charlie L: “I had a slight tear in the meniscus of my left knee that bothered me if I stood or sat for long. I applied Relief Rx™, and was amazed. In less than 20 seconds – literally, my knee was back to normal. I wasn’t expecting it to work that well or that quickly.”

4. Katie L (49): “I have used the Relief Rx™ many times when my muscles have been sore or my joints achy and each time, within minutes, the pain has diminished if not gone away completely. I don’t really understand why this happens, I just know it does. I appreciate the simplicity of the liquid – it is not thick, or smelly or difficult to use. And it seems to absorb quickly. It does not leave behind residue, any fragrance or greasy feeling. So I’m not so sure what is in it. I just know that it works wonders. Thank you for bringing this product to market. I’ve thrown out all of my other products and just use this.”

5. J.G.: “I have had severe pain in my right hand for over two years from using the mouse, pain in my arm, and recently I had surgery and developed a very uncomfortable pain on my right side from lying in bed. Every time I use Relief Rx™ I am amazed at how quickly the pain subsides and disappears. Thank you for this wonderful product!”

6. Dr. Chuck A.: “I applied Relief Rx™ on a patient that had nagging back issues. She told me she had “immediate and significant relief”. When can I get more?”

7. Mike G.: “I have played handball for 50 years. Over that time I have suffered right shoulder problem from injury, strain from over use, and tension from rotator cuff surgery. Over the past 15 years I have had to change shots due to shoulder problems and limitations. I applied Relief Rx™ and within 30 minutes I was 100%! I can hit all of the shots on the handball court like I could 15 years ago.”

8. U.: “This is the most amazing relief product I have ever experienced. I have disturbing problem in my back and it prevents me from getting a full nights sleep. Last night is the first night of continuous sleep I’ve had in more than a year.”

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RECENT ADVANCES IN LIPOSOME TECHNOLOGY

Dr. Hank Liers, PhD liposomes liposomal nutrientsHealth Products Distributors, Inc. recently decided to augment the variety of liposomal products we carry based upon the significant advancements of the technology during the last few years.

Among the benefits of using liposomes are that significantly higher levels of certain nutrients can be delivered directly to the cells where they are needed. In this article, I will discuss some of the recent scientific advances and new products associated with these advances.

Types of Liposomes

Figure 1 – liposomal types

SMALLER IS SIGNIFICANTLY BETTER

In December 2015, I wrote a blog article on liposomes to introduce the liposomal products we began selling at that time. Unfortunately, the particle size of these original products are on the order of 500 nanometers (nm), and as such are not nearly as well absorbed as the much smaller liposomes that have recently been developed by Quicksilver Scientific.

Figure 1 gives an overview of current liposome types. These include multi-lamellar vesicles (MLV) that range in size from 300–5,000 nm and have more than one bilayer.

Large unilamellar vesicles (LUV) range in size from 100–300 nm. They have a single bilayer and a high trapped volume, but have lower thermodynamic stability and decreased uptake.

Small unilamellar vesicles (SUV) range in size from 20–100 nm. SUV have a long circulation half-life and better cellular accumulation. Small lipid particles have the fastest uptake kinetics and can participate in paracellular (between cells) transport. The nutritional liposome industry is moving toward the use of SUV.

Small liposomes (SUV) are drastically more efficient at intracellular delivery of encapsulated compounds. In a recent study with carefully sized liposomes, cellular uptake increased nine-fold as liposome size was decreased from 236 nm to 97 nm and was 34 fold higher at 64 nm (see Figure 2). This figure shows flow cytometry results (a measure of cellular uptake) for Caco-2 cells incubated with liposomes containing Dil-C18 at 15 min and 60 min intervals.

Size effects of liposomes for cellular uptake

Figure 2 – Chart showing greatly enhanced absorption of liposomes as size decreases

 

HPDI CARRIES NEW LIPOSOMAL PRODUCTS

Our new liposomal product supplier currently is providing a wide range of products that have stable liposomes of about 50 nm. These products are bottled in such a way that they are taken by pumping (or squirting) the contents directly into your mouth (i.e., oral administration). This is an extremely clean method of dosing in which a few pumps of liposomal liquid can be rapidly taken or administered with no need for placing the product into separate glass of water or squeezing packets.

Because of the very small size much of the ingredients are absorbed through mucus membranes and into the system and cells extremely quickly (within seconds/minutes). In addition to the ingredients within the liposome, one gets significant amounts of phosphytidal choline into the cell membranes with a very beneficial effect on membrane function.

We are currently carrying the following Quicksilver Scientific liposomal products:

  1. Vitamin C with R-Lipoic Acid
  2. Glutathione
  3. Colorado Hemp Oil
  4. NanoMojo – a unique combination of 19 adaptogenic herbs

Quicksilver Liposomes

We highly encourage that you use the products because of the huge benefits they provide. We use them ourselves every day.

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BENEFITS OF GINKGO BILOBA EXTRACT

Dr. Hank Liers PhD gingko biloba extractHealth Products Distributors, Inc. (HPDI) has been carrying high-quality standardized Ginkgo Biloba extract (24/6) for more than 20 years. Ginkgo biloba extract is one of the best-selling herbal supplements in the United States and Europe because of its health benefits. Yet, because of severe price increases in ginkgo extract during the last few years, HPDI’s inventory was depleted. However, the price has now been greatly reduced for high-quality material—and we have inventory back in stock.

Ginkgo Biloba Tree

Ginkgo Biloba Tree

Ginkgo biloba has a long history of use (over thousands of years) in treating memory issues and blood disorders. Today, It is best known as a way to keep memory sharp. Laboratory studies have shown that Ginkgo biloba improves blood circulation by opening up blood vessels and making blood less sticky. Research studies also show that it is a powerful antioxidant.

Based upon these properties, Ginkgo biloba may improve blood vessel and eye health. Research has clearly shown that Ginkgo Biloba helps with dementia and poor circulation in the body. It also protects memory in older adults.

TECHNICAL DATA

Ginkgo leaves contain flavonoids and terpenoids, which are both antioxidants. In your body, harmful free radical substances build up as you age and may contribute to a range of health issues. The antioxidants found in Ginkgo biloba help to neutralize free radicals, and prevent them from damaging DNA and other cellular structures.

Leaves of Ginkgo Biloba Tree

Leaves of Ginkgo Biloba Tree

Chemical constituents: Ginkgo biloba leaf contains a complex mixture of flavonoids including: quercetin, kaempferol, isorhamnetin and other glycosides. It also contains unique diterpenes including ginkgolides A, B, C and J, sesquiterpene bilobalide, and other natural compounds that contribute in a synergistic manner to the beneficial actions of Ginkgo biloba.

Our GINKGO BILOBA extract contains only the highest-quality 50:1 extract of ginkgo biloba standardized to 24% minimum ginkgoflavonglycosides and 6% minimum combined ginkgolides A, B, C, and bilobalide. Each capsule contains 120 mg of the extract and their are 60 capsules in a bottle. Other ingredients include: microcrystalline cellulose, HPMC (vegetarian capsule), and silica. The ginkgolic acid content of the current production run is is 1.36ppm.

Here is the Certificate of Analysis of our current run of Ginkgo Biloba.

Ginkgo Biloba extract

Ginkgo Biloba 120 mg

 

SPECIFIC BENEFITS: GINKGO BILOBA EXTRACT

Reduces Conditions of Dementia: Scientific literature suggests that Ginkgo biloba extract benefits people experiencing cognitive decline, including those with dementia of Alzheimer’s disease (AD). Certain studies have found Ginkgo biloba can help improve cognitive performance and memory in both older and younger adults but might be especially useful for age-related mental decline.

Improves Concentration: Research shows that Ginkgo biloba extract can help combat poor concentration, reverse cognitive decline and and heal fatigue. It’s even useful for helping to treat cerebral insufficiency — a condition characterized by chronically low concentration, confusion, decreased physical performance, fatigue, headaches and mood changes.

Helps With ADHD: Some studies using therapies that include Ginkgo biloba have found relief and improved concentration for people with ADHD symptoms. And because it can improve concentration, memory and task performance, it may also reduce symptoms in people with dyslexia. There is also some evidence that ginkgo biloba can help reduce symptoms of autism, making it a potential autism natural treatment.

Helps with Headaches and Migraines: Ginkgo biloba can be an effective way to naturally reduce frequent headaches and the rate and severity of migraines because it reduces pain, increases blood vessel dilation and combats stress that can trigger problems. Headaches may be triggered by stress, fatigue, poor posture, drugs, low blood sugar, hormones, constipation, allergies, eyestrain, and nutritional deficiencies. The amazing benefits that ginkgo has on stress and fatigue is associated with its ability to lessen headache tension.

Helps With Anxiety and Depression: For those with nervousness, depression or mood swings, Ginkgo biloba extract can be helpful. Research suggests Ginkgo biloba benefits the body’s ability to handle stressors and counteracts the effects of high levels of stress hormones, like cortisol and adrenaline.

Ginkgo biloba is considered to be an adaptogenic herb that naturally raises the body’s ability to cope with stress. It can be especially helpful for people with generalized anxiety disorder (GAD) and possibly seasonal depression, panic attacks and social phobias.

Reduces Symptoms of Asthma: Studies have found Ginkgo biloba extract can reduce asthma-related symptoms. Because it lowers inflammation, improves antioxidant activity and positively effects nerve functioning, people have reported less trouble breathing when taking Ginkgo biloba.

Alleviates Symptoms of PMS: Early research has shown positive effects of taking Ginkgo biloba on reducing PMS symptoms, including mood swings, headaches, anxiety, fatigue and muscle pain. It also may have beneficial effects on mood and cognition in postmenopausal women and can help improve similar symptoms.

Helps Maintain Vision and Eye Health: Ginkgo biloba appears to be beneficial for eye health since it improves blood flow to the eyes and prevents free-radical damage that can affect the cornea, macula and retina. It can be especially beneficial for older adults in preserving vision and lowering UV damage or oxidative stress to eye tissue.

Improves Libido: Ginkgo biloba has positive effects on hormonal balance — particularly serotonin levels, blood pressure and circulation. This implies that it may help those dealing with erectile dysfunction and low libido. Ginkgo biloba has the potential to dilate blood vessels and improve blood flow to the genitals, which is important for reproductive health.

Helps Heal Hemorrhoids: Some studies have found that Ginkgo biloba helps those experiencing painful hemorrhoids, that cause swelling, pain and bleeding related to an increase in pressure on the veins of the anus and rectum. Ginkgo biloba may lower pain, improve pain tolerance and reduce inflammation, which may stop bleeding associated with hemorrhoids.

GINKGO BILOBA RESEARCH SUMMARY

Provided below are abstracts from some recent meta-analysis studies that document the effectiveness of Ginkgo biloba on mental health.

(ABSTRACT 1)
Tan MS, Yu JT, Tan CC, Wang HF, Meng XF, Wang C, Jiang T, Zhu XC, Tan L

Efficacy and adverse effects of ginkgo biloba for cognitive impairment and dementia: a systematic review and meta-analysis.

In: J Alzheimers Dis. 2015;43(2):589-603. doi: 10.3233/JAD-14083

Research into Ginkgo biloba has been ongoing for many years, while the benefit and adverse effects of Ginkgo biloba extract EGb761 for cognitive impairment and dementia has been discussed controversially.
OBJECTIVE: To discuss new evidence on the clinical and adverse effects of standardized Ginkgo biloba extract EGb761 for cognitive impairment and dementia.
METHODS: MEDLINE, EMBASE, Cochrane, and other relevant databases were searched in March 2014 for eligible randomized controlled trials of Ginkgo biloba EGb761 therapy in patients with cognitive impairment and dementia.
RESULTS: Nine trials met our inclusion criteria. Trials were of 22-26 weeks duration and included 2,561 patients in total. In the meta-analysis, the weighted mean differences in change scores for cognition were in favor of EGb761 compared to placebo (-2.86, 95%CI -3.18; -2.54); the standardized mean differences in change scores for activities in daily living (ADLs) were also in favor of EGb761 compared to placebo (-0.36, 95%CI -0.44; -0.28); Peto OR showed a statistically significant difference from placebo for Clinicians’ Global Impression of Change (CGIC) scale (1.88, 95%CI 1.54; 2.29). All these benefits are mainly associated with EGb761 at a dose of 240 mg/day. For subgroup analysis in patients with neuropsychiatric symptoms, 240 mg/day EGb761 improved cognitive function, ADLs, CGIC, and also neuropsychiatric symptoms with statistical superiority than for the whole group. For the Alzheimer’s disease subgroup, the main outcomes were almost the same as the whole group of patients with no statistical superiority. Finally, safety data revealed no important safety concerns with EGb761.
CONCLUSIONS: EGb761 at 240 mg/day is able to stabilize or slow decline in cognition, function, behavior, and global change at 22-26 weeks in cognitive impairment and dementia, especially for patients with neuropsychiatric symptoms.

(ABSTRACT 2)
Amieva H1, Meillon C, Helmer C, Barberger-Gateau P, Dartigues JF.

Ginkgo biloba extract and long-term cognitive decline: a 20-year follow-up population-based study.

In: PLoS One. 2013;8(1):e52755. doi: 10.1371/journal.pone.0052755. Epub 2013 Jan 11

BACKGROUND: Numerous studies have looked at the potential benefits of various nootropic drugs such as Ginkgo biloba extract (EGb761®; Tanakan®) and piracetam (Nootropyl®) on age-related cognitive decline often leading to inconclusive results due to small sample sizes or insufficient follow-up duration. The present study assesses the association between intake of EGb761® and cognitive function of elderly adults over a 20-year period.
METHODS AND FINDINGS: The data were gathered from the prospective community-based cohort study ‘Paquid’. Within the study sample of 3612 non-demented participants aged 65 and over at baseline, three groups were compared: 589 subjects reporting use of EGb761® at at least one of the ten assessment visits, 149 subjects reporting use of piracetam at one of the assessment visits and 2874 subjects not reporting use of either EGb761® or piracetam. Decline on MMSE, verbal fluency and visual memory over the 20-year follow-up was analysed with a multivariate mixed linear effects model. A significant difference in MMSE decline over the 20-year follow-up was observed in the EGb761® and piracetam treatment groups compared to the ‘neither treatment’ group. These effects were in opposite directions: the EGb761® group declined less rapidly than the ‘neither treatment’ group, whereas the piracetam group declined more rapidly (β = -0.6). Regarding verbal fluency and visual memory, no difference was observed between the EGb761® group and the ‘neither treatment’ group (respectively, β = 0.21 and β = -0.03), whereas the piracetam group declined more rapidly (respectively, β = -1.40 and β = -0.44). When comparing the EGb761® and piracetam groups directly, a different decline was observed for the three tests (respectively β = -1.07, β = -1.61 and β = -0.41).
CONCLUSION: Cognitive decline in a non-demented elderly population was lower in subjects who reported using EGb761® than in those who did not. This effect may be a specific medication effect of EGb761®, since it was not observed for another nootropic medication, piracetam.

(ABSTRACT 3)
Zhang HF, Huang LB, Zhong YB, Zhou QH, Wang HL, Zheng GQ, Lin Y

[An Overview of Systematic Reviews of Ginkgo biloba Extracts for Mild Cognitive Impairment and Dementia.

In: Front Aging Neurosci. 2016 Dec 6;8:276. doi: 10.3389/fnagi.2016.00276. eCollection 2016

Ginkgo biloba extracts (GBEs) have been recommended to improve cognitive function and to prevent cognitive decline, but earlier evidence was inconclusive. Here, we evaluated all systematic reviews of GBEs for prevention of cognitive decline, and intervention of mild cognitive impairment (MCI) and dementia. Six databases from their inception to September 2015 were searched. Ten systematic reviews were identified, including reviews about Alzheimer’s disease (n = 3), about vascular dementia (n = 1), about both Alzheimer’s disease and vascular dementia (n = 2), about Alzheimer’s disease, vascular dementia and mixed dementia (n = 3), and a review about MCI (n = 1). Based on the overview quality assessment questionnaire, eight studies were scored with at least 5 points, while the other two scored 4 points and 3 points, respectively. Medication with GBEs showed improvement in cognition, neuropsychiatric symptoms, and daily activities, and the effect was dose-dependent. Efficacy was convincingly demonstrated only when high daily dose (240 mg) was applied. Compared with placebo, overall adverse events and serious adverse events were at the same level as placebo, with less adverse events in favor of GBE in the subgroup of Alzheimer’s disease patients, and fewer incidences in vertigo, tinnitus, angina pectoris, and headache. In conclusion, there is clear evidence to support the efficacy of GBEs for MCI and dementia, whereas the question on efficacy to prevent cognitive decline is still open. In addition, GBEs seem to be generally safe.

(ABSTRACT 4)
Hashiguchi M, Ohta Y, Shimizu M, Maruyama J, Mochizuki M.

[Meta-analysis of the efficacy and safety of Ginkgo biloba extract for the treatment of dementia.In: J Fr Ophtalmol (1988) 11(10):671-4 (Published in French)]

In: J Pharm Health Care Sci. 2015 Apr 10;1:14. doi: 10.1186/s40780-015-0014-7. eCollection 2015.

The benefit of Ginkgo biloba for the treatment of dementia remains controversial. The aim of this study was to evaluate the efficacy and safety of Ginkgo biloba in patients with dementia in whom administration effects were reported using meta-analysis.
METHODS: We searched MEDLINE, Embase, the Cochrane databases, and Ichushi for controlled trials of Ginkgo biloba for the treatment dementia. Clinical characteristics and outcomes were extracted. Meta-analysis results were expressed as standard mean differences (SMDs) in scores of the Syndrome Kurztest (SKT), Alzheimer’s Disease Assessment Scale Cognitive Subscale (ADAS-Cog) for cognition efficacy, or odds ratios (ORs) for dropouts and adverse drug reactions.
RESULTS: Thirteen studies using the extract EGb761 met our inclusion criteria, which were duration of 12 to 52 weeks and daily dose of more than 120 mg, and included a total of 2381 patients. Meta-analysis was performed by using 9 of 13 studies, 7 of which used the SKT and 2 ADAS-Cog (dose 120 mg, 26 weeks) scores as efficacy parameters. In meta-analysis of all patients, SMDs (95% confidence interval [CI]) in the change in SKT scores (7 studies) were in favor of Ginkgo biloba over placebo (SMD = -0.90 [-1.46, -0.34]), but 2 studies that used ADAS-Cog did not show a statistically significant difference from placebo for ADAS-Cog (-0.06 [-0.41, 0.30]). For Alzheimer’s disease (AD) and vascular dementia (VaD) subgroups, SMDs [95% CI] in SKT in the combined AD and VaD subgroup (-1.07 [-1.66, -0.47]) and AD subgroup (-1.36 [-2.27, -0.46]) were in favor of Ginkgo biloba over placebo. In terms of daily dose of Ginkgo biloba in the combined AD and VaD subgroup, SMD in SKT score in 240-mg daily dose groups was significantly greater than with placebo (-0.71 [-1.28, -0.14]). Dropout rates for any reason did not differ between two groups, but dropout rates due to side effects were significantly lower in Ginkgo biloba groups compared with placebo groups (OR = 1.72 [1.06, 2.80]).
CONCLUSIONS: Taking a 240-mg daily dose of Ginkgo biloba extract is effective and safe in the treatment of dementia.

For a more extensive list of Ginkgo Biloba abstracts go here.

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DISCOVERING NUTRITIONAL NEEDS THROUGH ADVANCED GENETIC TESTING

Dr. Hank Liers, PhD genetic testing bodysync

Last fall we exhibited at the American Academy for Advancement in Medicine (ACAM) annual meeting and were delighted to discover BodySync, a company specializing in genetic testing. BodySync is committed to empowering individuals to make informed nutrition and fitness decisions based on their key personal genetic data.

BodySync’s novel approach to personal wellness incorporates advanced genotyping and lifestyle analyses of genes which research has shown to have impact on nutrient metabolism and fitness capacity.

Developed by leading genetic scientists, genomic nutritionists, kinesiologists, and bioinformaticians, BodySync’s clinically tested DNA Nutrition and Fitness Systems are used by thousands of health care professionals, physicians, and researchers around the world.

Genetic Testing

In our discussions it became clear there is a good match between what BodySync scientists learn from genetic testing and the high-quality products Health Products Distributors, Inc. (HPDI) offers that can be used to correct for nutritional deficiencies identified in the testing.

It is HPDI’s intention to associate with BodySync by introducing our professional clients to the test, including selling the test on our Reseller website and offering our recommended products to health professionals and their patients who participate in BodySync’s genetic testing.

THE POTENTIAL OF NUTRITIONAL GENOMICS

The first insights of how nutritional genomics will impact personal health have already begun to be appreciated. As research goes forward, we expect a continually expanding knowledge base that promises to have extensive benefits for health care in general and personal health in particular.

Major Anticipated Contributions

  • Greater understanding of the role of genetics in health and disease (particularly chronic disease)
  • More effective therapeutic interventions for dealing with existing disease.
  • Early identification of disease susceptibility and initiation of risk reduction strategies.
  • A shift within health care from a disease management focus to one of health promotion and disease prevention.
  • Identification of the molecular mechanisms underpinning the interactions among genes and environmental factors, including components in food.
  • Individualization of dietary choices based on a person’s genotype.
  • A new dimension to food, one of genes being dietary targets with food having the ability to change gene expression.
  • Changes in food choices, including: a) increased selection of functional foods that scientific research has shown to reduce susceptibility to diet-related diseases, b) isolation and purification of bioactive food components for use in development of new functional foods or for enrichment of commonly eaten foods and dietary supplements.
  • Public health messages conveying the role of genes and environment in health and disease and the ability of food to modify the outcome of these interactions, allowing diet and health to be tailored to an individual’s genetic variations.
  • Empowerment of consumers to take responsibility for their health through enhanced knowledge of appropriate food choices for their genotype.

Such benefits will be possible because of existing and emerging research findings associated with nutritional genomics, as described in the points that follow.

INTERACTIONS BETWEEN GENES AND FOOD

One such finding is the discovery that there is the molecular equivalent of communication between genes and environmental factors, including bioactive molecules found in food. Our genes impact how we respond to different food choices. Likewise, the food choices we make influence the “goodness-of-fit” between us and our environment as well as the expression of our genes.

The sum total of these interactions adds up to whether we will survive and thrive in a particular environment. For conditions that are diet-related, there is the potential to modify disease expression and severity by changing key environmental factors, such as our food and lifestyle choices.

GENETIC UNIQUENESS OF INDIVIDUALS

Another finding is the recognition that each individual is genetically unique. Although all human beings share virtually the same type and amount of genetic information, subtle differences—called genetic variations—make each of us slightly different, from our physical appearance to our responses to food. Advances in genetic technology make it possible to detect these genetic variations so that each person’s genetic signature can be identified and factored into our diet and lifestyle choices. This knowledge is leading to more personalized medical care, as well as a sense of personal responsibility for one’s health.

POTENTIAL FOR DIET TO CHANGE DISEASE OUTCOMES

An important finding is that many of today’s common, chronic diseases are, in part, diet-related. These diseases are being associated with particular genes and, within those genes, with specific genetic variations and their interaction with specific bioactive components within food.

Many disease outcomes, including those for which we are genetically susceptible, may be increasingly modifiable through targeted diet and lifestyle choices, affording us new approaches to managing existing disease and the potential for preventing future disease. As specific bioactive components in food are identified and isolated, food will take on a new dimension.

Particular foods will be promoted as beneficial for particular genetic variations. New functional foods will be available and some of the purified bioactive food components will be used to fortify commonly eaten foods.

MORE ABOUT BODYSYNC GENETIC TESTING PROGRAMS

BodySync Personal Genetics provides advanced nutrition and fitness tools to individuals, healthcare professionals, and organizations seeking a proactive and more personal approach to wellness. BodySync DNA Nutrition and Fitness™ Assessments and Solutions Systems are based on multi-patented suites of well-researched gene/nutrient and gene/fitness associations.

BodySync’s genotyping services are carried out in a wholly owned, CLIA-Certified laboratory. Customer data is processed through proprietary Gene/Lifestyle™ Integration technology in secure data centers.

Simple Action Plans designed to improve nutrition and fitness programs are prepared based upon assessment results and personal questionnaire data. The following figure shows an aspect of the benefits of the BodySync Action Plan.

Benefits of BodySync Action Plan genetic testing

GENETIC ASSESSMENTS

BodySync develops DNA Assessments targeting gene/nutrient and gene/fitness connections that are backed by well-established clinical research. Analyzing a carefully selected but robust number of genes, BodySync DNA™ Nutrition and Fitness Assessments focus on genetic variations that have been frequently associated with an individual’s ability to metabolize specific nutrients and benefit from certain types of exercise.

BodySync develops a variety of genetic assessments for different wellness applications, and are focused on healthy nutrition and/or fitness measures that can be implemented at home. BodySync DNA Assessments are simple and practical. Individuals provide DNA-rich cheek swab samples to BodySync’s in-house CLIA-Certified DNA Laboratory, along with an in-depth, online LifeStyle Questionnaire.

Genetic assessment results are combined with questionnaire data using BodySync’s proprietary Gene/Lifestyle™ Integration Technology, which generates an Action Plan that includes nutrient metabolism and detailed athletic profiling information.

GENETIC ACTION PLANS

BodySync Action Plans are prepared in easy-to-understand language, including simple graphics, and provide guidance on achieving nutrition and/or fitness goals. Customers can update the LifeStyle Questionnaire periodically and receive new Action Plans to track progress. The genetic data underpinning BodySync Action Plans can be used to “genotype,” generating updated nutrition and fitness programs, or create new personalized meal and workout planning programs.

BodySync’s highly sophisticated and individualized nutrition and fitness strategy tools are not replacements for expert advice from a certified personal training professional and/or physician. BodySync DNA Assessments are neither diagnostic nor predictive of disease and are not available to the public as stand-alone products.

BodySync technology is designed to develop unique assessments and are available through a select group of distributors, physicians, health care, nutrition, fitness, gym, and corporate wellness professionals.

DNA HEALTH & WELLNESS

BodySync DNA Assessments target gene/nutrient and gene/fitness associations based on well-researched, clinically documented genetic correlations to nutrient metabolism and exercise benefit potential.

BodySync DNA Assessment and Solutions Systems can provide individuals with important insight into gene and lifestyle factors that may play a role in enhanced nutrition and fitness. It this way it may help individuals and organizations identify potentially new wellness opportunities based on genetics.

DNA NUTRITION SYSTEMS

Knowledge about genes and lifestyle can provide important guidance on which nutrients can potentially work most effectively with your system. BodySync DNA Nutrition™ Systems include key genetic assessments, practical action plans, and important data that can help individuals and organizations add personalization to diet strategies. This can transform personal nutrition based on the vast potential of nutrigenetic science.

Initially designed for nutrition professionals, BodySync DNA Nutrition™ Assessments, Action Plans, and Solutions Systems provide individuals with practical dietary insights and advice based on a combination of an advanced nutrigenetic analysis and online LifeStyle Questionnaire results.

NUTRIGENETIC DATA APPLICATIONS

The genetic data providing the foundation of BodySync Nutrition Action Plans can be used to “genotype,” update existing nutrition programs, or create new meal planning systems, based on an individual’s nutrigenetic profile. BodySync genetically guided nutrition systems can be adapted to help organizations develop and enhance ongoing nutrition programs, as well as help individuals strive to reach their genetic nutrition potential.

BodySync’s DNA Nutrition Assessments include a personal Action Plan, which can provide the basis for a host of genetically guided nutrition products and services, including the development of highly personalized diet regimens and companion products.

BodySync DNA Nutrition Assessments are the subject of ongoing nutrigenomic clinical studies designed to validate the utility of genetics in supporting healthy nutrition.

THE PATIENT’S EXPERIENCE

EASY TO FOLLOW PROCESS – EASY TO READ RESULTS

Once a medical professional gives a patient a NutriSync Assessment package, the patient registers online, completes an online Lifestyle Survey, collects their DNA using the provided cheek swabs, and send their cheek swabs to our CLIA-certified laboratory. The patient’s DNA results are combined with their LifeStyle Survey answers using an advanced Gene/Lifestyle™ Integration Technology. About a month later, the medical professional receives a Report Summary for the patient. 48 hours later, the patient will be notified via email that their NutriSync Action Plan is ready to view on their HIPAA-secure, private web portal.BodySync genetic testing

THE FUTURE: COMING SOON

In the next several months we hope to start selling the NutriSync Assessment package on our Reseller website. In addition, we will prepare a blog article providing many details concerning the genetic testing that is done in the NutriSync Assessment program. On our Retail website we will provide information concerning the NutriSync Assessment package and how a person can learn more and sign up for the program.

 

 

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PRO-C AND ULTIMATE PROTECTOR – COMPARISON OF ANTIOXIDANT FORMULAS

Dr. Hank Liers, PhD antioxidant formulasI have written extensively regarding the benefits HPDI’s PRO-C™ and Ultimate Protector™ antioxidant formulas. Based upon my experience with these formulas they are among the most effective antioxidant formulas available.

Both antioxidant formulas are included in HPDI’s system of foundational supplements and work most effectively when used with multivitamins, essential fats, and superfoods.

Yet, both formulas also are excellent standalone products that can rapidly provide the body with extremely high protection against free radicals.
Ultimate Protector antioxidant formulas

We are often asked “which of these two antioxidant formulas should I take?” My answer usually is to take both formulas. I personally take both of them on a daily basis.

Below I will briefly show the reason my answer is to take both formulas. I include information showing the relationship, in terms of ingredients of the two formulas (per serving of three (3) capsules daily of PRO-C and six (6) capsules daily of Ultimate Protector).

Ultimate Protector

INGREDIENTS OF ANTIOXIDANT FORMULAS

PRO-C™ (per serving of three “00” veggie caps)

• Buffered non-GMO Vitamin C (1,500 mg)  buffered with Ca/Mg/Zn
• Grape Extract (seed, skin, and pulp) (90 mg)
• Green Tea Extract 95% polyphenols 40% min. EGCG (90 mg)
• Glutathione – reduced (60 mg)
• N-Acetyl-l-Cysteine (NAC) (45 mg)
• R-Lipoic Acid (15 mg)
• Coenzyme B2/R5P (3 mg)
• Coenzyme B6/P5P (3 mg)
• Selenium from l-selenomethionine (30 mcg)
• Calcium (70 mg)
• Magnesium (70 mg)
• Zinc (6 mg)

ULTIMATE PROTECTOR™ (per serving of six “0” veggie caps)

• Vitamin C as non-GMO Ascorbic acid (1500 mg)
• Anthocomplete™ (135 mg)  Wild Blueberry, Wild Bilberry, Acai, Black Currant Extract, Sweet Cherry, Raspberry, Elderberry, Blackberry, Aronia, Black Soybean Hull Extract, and Blue Corn
• CoffeeBerry®Forte (135 mg)
• Vitaberry® Plus (90 mg) freeze-dried Grape Seed, Wild Blueberry, Wild Bilberry, Cranberry, Tart Cherry, Prune, Raspberry Seed, Strawberry, Trans-Resveratrol, and Quercetin
• VitaVeggie® (90 mg)  Broccoli, Broccoli Sprouts, Tomato, Kale, Carrot, Brussels Sprouts, Onion, and Spinach
• Curcumin 95%  (90 mg)
• Trans-Resveratrol 98% (90 mg)
• Malic Acid (500 mg)
• Calcium (60 mg)
• Magnesium (60 mg)
• BioPerine® (7.5 mg)

The products together contain nine (9) unique PRO-C™ ingredients, eight (8) unique Ultimate Protector™ ingredients, and three (3) overlapping ingredients.

DISCUSSION OF ANTIOXIDANT FORMULAS

PRO-C™

When PRO-C™ was first released in 1997 there were few publications available regarding Nrf2 ingredients and their benefits. The product design was based on the work of Dr. Lester Packer and his work done on the “Antioxidant Network” showing how nutrients such as Vitamin E, Vitamin C, Glutathione, and Lipoic acid work in a redox network to regenerate key nutrients in the body (see Figure 1. below)

doctor lester packer antioxidant formulas

                                                Figure 1. – Dr. Packer’s Antioxidant Network

At that time the powerful antioxidant formulas of Grape Seed Extract and Green Tea Extract were well known, but their powerful Nrf2 effects were not discovered until later. These ingredients are able to trap free radicals and conserve the body’s store of network antioxidants.

Also, the Nrf2 effects of NAC and Lipoic acid were not known at the time, but their powerful effects on the body were known to support the production of glutathione. Additionally, the super powerful glutathione (reduced) was included with supporting coenzymes B2 (from riboflavin 5′-phosphate) and B6 (from pyridoxal 5′-phosphate) that allow the enzymes glutathione reductase and transferase to function at a higher level.

ULTIMATE PROTECTOR™

From the beginning of the design process, Ultimate Protector™ (UP) was focused on creating a highly effective Nrf2 activator formula with outstanding antioxidant effects. Our understanding was that a very broad spectrum of plant polyphenols including flavonoids, anthocyandins, oligoproanthocyanidins (OPCs), etc. would deliver the best results.

We selected Futureceuticals Anthocomplete™, CoffeeBerry® Forte, Vitaberry® Plus, and VitaVeggie® in order to accomplish this and added Curcumin 95%, and Trans-Resveratrol 98% because of the powerful scientific findings regarding Nrf2 activation for these two ingredients. We found out later in testing that this combination of ingredients produces very high ORAC5.0 values (486,000 units/serving of six capsules) and works effectively against all of the primary types of free radicals in the body.

WHY TAKE BOTH PRO-C™ AND
ULTIMATE PROTECTOR™ ANTIOXIDANT FORMULAS?

Ultimate Protector versus PRO-C antioxidant formulas

Venn diagram showing unique and overlapping ingredients in PRO-C and Ultimate Protector.

There are 29 unique Nrf2 activator ingredients in Ultimate Protector (UP) and four (4) non-overlapping Nrf2 activator ingredients in PRO-C. Thus by taking both formulas you are able to receive 33 identifiable Nrf2 activator ingredients (870 mg). The amount of unique Nrf2 ingredients is probably significantly more than this because most of the identifiable ingredients contain a range of plant polyphenols.

Other unique ingredients of each formula include glutathione – reduced (60 mg), malic acid (500 mcg), zinc (6 mg), selenium (30 mcg), B2 (3 mg) and B6 (3 mg) from coenzyme forms, and Bioperine (7.5 mg) (for enhanced absorption of nutrients). These are important ingredients to have the formulas work more effectively together.

The overlapping ingredients in the formula include Vitamin C (3 gm – 1.5 gm from each formula), calcium (130 mg – 70 mg from PRO-C & 60 mg from UP), magnesium (130 mg – 70 mg from PRO-C & 60 mg from UP), and a little grape seed extract (~10 mg). We view this to be very positive especially because we believe that most people should take in at least 3 grams daily of Vitamin C. Equal amounts of calcium and magnesium balance each other in the body and have many important functions such as being part of critical enzymes.

SOURCES & RESOURCES

The Antioxidant Miracle. Lester Packer, PhD, and Carol Coleman. New York: John Wiley and Sons, 1999.

“Antioxidant Cocktail Update: Part 1: The Take Home Message is to Use Antioxidant Supplements”
(Interview of Dr. Lester Packer by Richard A. Passwater, PhD, Whole Foods Magazine, 1999)

HPDI BLOG ARTICLES

CONTACT US:

You can reach HPDI by calling 1-800-228-4265, email support(at)IntegratedHealth.com, or visit the retail website: IntegratedHealth.com

Health care professionals and resellers can apply for wholesale account, which includes access to the HPDI reseller website: HealthProductsDistributors.com. Email: Support(at)HealthProductsDistributors.com.