Dr. Hank Liers PhD gingko biloba extractHealth Products Distributors, Inc. (HPDI) has been carrying high-quality standardized Ginkgo Biloba extract (24/6) for more than 20 years. Ginkgo biloba extract is one of the best-selling herbal supplements in the United States and Europe because of its health benefits. Yet, because of severe price increases in ginkgo extract during the last few years, HPDI’s inventory was depleted. However, the price has now been greatly reduced for high-quality material—and we have inventory back in stock.

Ginkgo Biloba Tree

Ginkgo Biloba Tree

Ginkgo biloba has a long history of use (over thousands of years) in treating memory issues and blood disorders. Today, It is best known as a way to keep memory sharp. Laboratory studies have shown that Ginkgo biloba improves blood circulation by opening up blood vessels and making blood less sticky. Research studies also show that it is a powerful antioxidant.

Based upon these properties, Ginkgo biloba may improve blood vessel and eye health. Research has clearly shown that Ginkgo Biloba helps with dementia and poor circulation in the body. It also protects memory in older adults.


Ginkgo leaves contain flavonoids and terpenoids, which are both antioxidants. In your body, harmful free radical substances build up as you age and may contribute to a range of health issues. The antioxidants found in Ginkgo biloba help to neutralize free radicals, and prevent them from damaging DNA and other cellular structures.

Leaves of Ginkgo Biloba Tree

Leaves of Ginkgo Biloba Tree

Chemical constituents: Ginkgo biloba leaf contains a complex mixture of flavonoids including: quercetin, kaempferol, isorhamnetin and other glycosides. It also contains unique diterpenes including ginkgolides A, B, C and J, sesquiterpene bilobalide, and other natural compounds that contribute in a synergistic manner to the beneficial actions of Ginkgo biloba.

Our GINKGO BILOBA extract contains only the highest-quality 50:1 extract of ginkgo biloba standardized to 24% minimum ginkgoflavonglycosides and 6% minimum combined ginkgolides A, B, C, and bilobalide. Each capsule contains 120 mg of the extract and their are 60 capsules in a bottle. Other ingredients include: microcrystalline cellulose, HPMC (vegetarian capsule), and silica. The ginkgolic acid content of the current production run is is 1.36ppm.

Here is the Certificate of Analysis of our current run of Ginkgo Biloba.

Ginkgo Biloba extract

Ginkgo Biloba 120 mg



Reduces Conditions of Dementia: Scientific literature suggests that Ginkgo biloba extract benefits people experiencing cognitive decline, including those with dementia of Alzheimer’s disease (AD). Certain studies have found Ginkgo biloba can help improve cognitive performance and memory in both older and younger adults but might be especially useful for age-related mental decline.

Improves Concentration: Research shows that Ginkgo biloba extract can help combat poor concentration, reverse cognitive decline and and heal fatigue. It’s even useful for helping to treat cerebral insufficiency — a condition characterized by chronically low concentration, confusion, decreased physical performance, fatigue, headaches and mood changes.

Helps With ADHD: Some studies using therapies that include Ginkgo biloba have found relief and improved concentration for people with ADHD symptoms. And because it can improve concentration, memory and task performance, it may also reduce symptoms in people with dyslexia. There is also some evidence that ginkgo biloba can help reduce symptoms of autism, making it a potential autism natural treatment.

Helps with Headaches and Migraines: Ginkgo biloba can be an effective way to naturally reduce frequent headaches and the rate and severity of migraines because it reduces pain, increases blood vessel dilation and combats stress that can trigger problems. Headaches may be triggered by stress, fatigue, poor posture, drugs, low blood sugar, hormones, constipation, allergies, eyestrain, and nutritional deficiencies. The amazing benefits that ginkgo has on stress and fatigue is associated with its ability to lessen headache tension.

Helps With Anxiety and Depression: For those with nervousness, depression or mood swings, Ginkgo biloba extract can be helpful. Research suggests Ginkgo biloba benefits the body’s ability to handle stressors and counteracts the effects of high levels of stress hormones, like cortisol and adrenaline.

Ginkgo biloba is considered to be an adaptogenic herb that naturally raises the body’s ability to cope with stress. It can be especially helpful for people with generalized anxiety disorder (GAD) and possibly seasonal depression, panic attacks and social phobias.

Reduces Symptoms of Asthma: Studies have found Ginkgo biloba extract can reduce asthma-related symptoms. Because it lowers inflammation, improves antioxidant activity and positively effects nerve functioning, people have reported less trouble breathing when taking Ginkgo biloba.

Alleviates Symptoms of PMS: Early research has shown positive effects of taking Ginkgo biloba on reducing PMS symptoms, including mood swings, headaches, anxiety, fatigue and muscle pain. It also may have beneficial effects on mood and cognition in postmenopausal women and can help improve similar symptoms.

Helps Maintain Vision and Eye Health: Ginkgo biloba appears to be beneficial for eye health since it improves blood flow to the eyes and prevents free-radical damage that can affect the cornea, macula and retina. It can be especially beneficial for older adults in preserving vision and lowering UV damage or oxidative stress to eye tissue.

Improves Libido: Ginkgo biloba has positive effects on hormonal balance — particularly serotonin levels, blood pressure and circulation. This implies that it may help those dealing with erectile dysfunction and low libido. Ginkgo biloba has the potential to dilate blood vessels and improve blood flow to the genitals, which is important for reproductive health.

Helps Heal Hemorrhoids: Some studies have found that Ginkgo biloba helps those experiencing painful hemorrhoids, that cause swelling, pain and bleeding related to an increase in pressure on the veins of the anus and rectum. Ginkgo biloba may lower pain, improve pain tolerance and reduce inflammation, which may stop bleeding associated with hemorrhoids.


Provided below are abstracts from some recent meta-analysis studies that document the effectiveness of Ginkgo biloba on mental health.

Tan MS, Yu JT, Tan CC, Wang HF, Meng XF, Wang C, Jiang T, Zhu XC, Tan L

Efficacy and adverse effects of ginkgo biloba for cognitive impairment and dementia: a systematic review and meta-analysis.

In: J Alzheimers Dis. 2015;43(2):589-603. doi: 10.3233/JAD-14083

Research into Ginkgo biloba has been ongoing for many years, while the benefit and adverse effects of Ginkgo biloba extract EGb761 for cognitive impairment and dementia has been discussed controversially.
OBJECTIVE: To discuss new evidence on the clinical and adverse effects of standardized Ginkgo biloba extract EGb761 for cognitive impairment and dementia.
METHODS: MEDLINE, EMBASE, Cochrane, and other relevant databases were searched in March 2014 for eligible randomized controlled trials of Ginkgo biloba EGb761 therapy in patients with cognitive impairment and dementia.
RESULTS: Nine trials met our inclusion criteria. Trials were of 22-26 weeks duration and included 2,561 patients in total. In the meta-analysis, the weighted mean differences in change scores for cognition were in favor of EGb761 compared to placebo (-2.86, 95%CI -3.18; -2.54); the standardized mean differences in change scores for activities in daily living (ADLs) were also in favor of EGb761 compared to placebo (-0.36, 95%CI -0.44; -0.28); Peto OR showed a statistically significant difference from placebo for Clinicians’ Global Impression of Change (CGIC) scale (1.88, 95%CI 1.54; 2.29). All these benefits are mainly associated with EGb761 at a dose of 240 mg/day. For subgroup analysis in patients with neuropsychiatric symptoms, 240 mg/day EGb761 improved cognitive function, ADLs, CGIC, and also neuropsychiatric symptoms with statistical superiority than for the whole group. For the Alzheimer’s disease subgroup, the main outcomes were almost the same as the whole group of patients with no statistical superiority. Finally, safety data revealed no important safety concerns with EGb761.
CONCLUSIONS: EGb761 at 240 mg/day is able to stabilize or slow decline in cognition, function, behavior, and global change at 22-26 weeks in cognitive impairment and dementia, especially for patients with neuropsychiatric symptoms.

Amieva H1, Meillon C, Helmer C, Barberger-Gateau P, Dartigues JF.

Ginkgo biloba extract and long-term cognitive decline: a 20-year follow-up population-based study.

In: PLoS One. 2013;8(1):e52755. doi: 10.1371/journal.pone.0052755. Epub 2013 Jan 11

BACKGROUND: Numerous studies have looked at the potential benefits of various nootropic drugs such as Ginkgo biloba extract (EGb761®; Tanakan®) and piracetam (Nootropyl®) on age-related cognitive decline often leading to inconclusive results due to small sample sizes or insufficient follow-up duration. The present study assesses the association between intake of EGb761® and cognitive function of elderly adults over a 20-year period.
METHODS AND FINDINGS: The data were gathered from the prospective community-based cohort study ‘Paquid’. Within the study sample of 3612 non-demented participants aged 65 and over at baseline, three groups were compared: 589 subjects reporting use of EGb761® at at least one of the ten assessment visits, 149 subjects reporting use of piracetam at one of the assessment visits and 2874 subjects not reporting use of either EGb761® or piracetam. Decline on MMSE, verbal fluency and visual memory over the 20-year follow-up was analysed with a multivariate mixed linear effects model. A significant difference in MMSE decline over the 20-year follow-up was observed in the EGb761® and piracetam treatment groups compared to the ‘neither treatment’ group. These effects were in opposite directions: the EGb761® group declined less rapidly than the ‘neither treatment’ group, whereas the piracetam group declined more rapidly (β = -0.6). Regarding verbal fluency and visual memory, no difference was observed between the EGb761® group and the ‘neither treatment’ group (respectively, β = 0.21 and β = -0.03), whereas the piracetam group declined more rapidly (respectively, β = -1.40 and β = -0.44). When comparing the EGb761® and piracetam groups directly, a different decline was observed for the three tests (respectively β = -1.07, β = -1.61 and β = -0.41).
CONCLUSION: Cognitive decline in a non-demented elderly population was lower in subjects who reported using EGb761® than in those who did not. This effect may be a specific medication effect of EGb761®, since it was not observed for another nootropic medication, piracetam.

Zhang HF, Huang LB, Zhong YB, Zhou QH, Wang HL, Zheng GQ, Lin Y

[An Overview of Systematic Reviews of Ginkgo biloba Extracts for Mild Cognitive Impairment and Dementia.

In: Front Aging Neurosci. 2016 Dec 6;8:276. doi: 10.3389/fnagi.2016.00276. eCollection 2016

Ginkgo biloba extracts (GBEs) have been recommended to improve cognitive function and to prevent cognitive decline, but earlier evidence was inconclusive. Here, we evaluated all systematic reviews of GBEs for prevention of cognitive decline, and intervention of mild cognitive impairment (MCI) and dementia. Six databases from their inception to September 2015 were searched. Ten systematic reviews were identified, including reviews about Alzheimer’s disease (n = 3), about vascular dementia (n = 1), about both Alzheimer’s disease and vascular dementia (n = 2), about Alzheimer’s disease, vascular dementia and mixed dementia (n = 3), and a review about MCI (n = 1). Based on the overview quality assessment questionnaire, eight studies were scored with at least 5 points, while the other two scored 4 points and 3 points, respectively. Medication with GBEs showed improvement in cognition, neuropsychiatric symptoms, and daily activities, and the effect was dose-dependent. Efficacy was convincingly demonstrated only when high daily dose (240 mg) was applied. Compared with placebo, overall adverse events and serious adverse events were at the same level as placebo, with less adverse events in favor of GBE in the subgroup of Alzheimer’s disease patients, and fewer incidences in vertigo, tinnitus, angina pectoris, and headache. In conclusion, there is clear evidence to support the efficacy of GBEs for MCI and dementia, whereas the question on efficacy to prevent cognitive decline is still open. In addition, GBEs seem to be generally safe.

Hashiguchi M, Ohta Y, Shimizu M, Maruyama J, Mochizuki M.

[Meta-analysis of the efficacy and safety of Ginkgo biloba extract for the treatment of dementia.In: J Fr Ophtalmol (1988) 11(10):671-4 (Published in French)]

In: J Pharm Health Care Sci. 2015 Apr 10;1:14. doi: 10.1186/s40780-015-0014-7. eCollection 2015.

The benefit of Ginkgo biloba for the treatment of dementia remains controversial. The aim of this study was to evaluate the efficacy and safety of Ginkgo biloba in patients with dementia in whom administration effects were reported using meta-analysis.
METHODS: We searched MEDLINE, Embase, the Cochrane databases, and Ichushi for controlled trials of Ginkgo biloba for the treatment dementia. Clinical characteristics and outcomes were extracted. Meta-analysis results were expressed as standard mean differences (SMDs) in scores of the Syndrome Kurztest (SKT), Alzheimer’s Disease Assessment Scale Cognitive Subscale (ADAS-Cog) for cognition efficacy, or odds ratios (ORs) for dropouts and adverse drug reactions.
RESULTS: Thirteen studies using the extract EGb761 met our inclusion criteria, which were duration of 12 to 52 weeks and daily dose of more than 120 mg, and included a total of 2381 patients. Meta-analysis was performed by using 9 of 13 studies, 7 of which used the SKT and 2 ADAS-Cog (dose 120 mg, 26 weeks) scores as efficacy parameters. In meta-analysis of all patients, SMDs (95% confidence interval [CI]) in the change in SKT scores (7 studies) were in favor of Ginkgo biloba over placebo (SMD = -0.90 [-1.46, -0.34]), but 2 studies that used ADAS-Cog did not show a statistically significant difference from placebo for ADAS-Cog (-0.06 [-0.41, 0.30]). For Alzheimer’s disease (AD) and vascular dementia (VaD) subgroups, SMDs [95% CI] in SKT in the combined AD and VaD subgroup (-1.07 [-1.66, -0.47]) and AD subgroup (-1.36 [-2.27, -0.46]) were in favor of Ginkgo biloba over placebo. In terms of daily dose of Ginkgo biloba in the combined AD and VaD subgroup, SMD in SKT score in 240-mg daily dose groups was significantly greater than with placebo (-0.71 [-1.28, -0.14]). Dropout rates for any reason did not differ between two groups, but dropout rates due to side effects were significantly lower in Ginkgo biloba groups compared with placebo groups (OR = 1.72 [1.06, 2.80]).
CONCLUSIONS: Taking a 240-mg daily dose of Ginkgo biloba extract is effective and safe in the treatment of dementia.

For a more extensive list of Ginkgo Biloba abstracts go here.



Fred Liers PhD intestinal rejuvenation formula gut healthIntestinal and digestive tract health are critical for health. “All disease begins in the bowel” is a mantra for herbalists and natural healers. Healthy gut structure and function is important for digestion of food, assimilation of nutrients, elimination of wastes, detoxification, and even brain function and mental health due to reciprocal relations along the gut-brain axis.

Intestinal Rejuvenation Formula gut health

HPDI offers several products formulated for optimal gut health. That is, nutritional supplements intended to improve intestinal and digestive system health and function. These formulas include probiotics like Prescript-Assist™ (soil-based organisms), Restore For Gut Health (lignite formula), digestive enzymes, and Intestinal Rejuvenation Formula.

When used as part of an overall program of gut health and especially when combined with an excellent, whole-foods diet, these gut-health formulas help optimize intestinal health in a world fraught with environmental factors and lifestyle elements that can destroy GI tract health. I will talk about some of these products in this article. However, my main focus will be upon Intestinal Rejuvenation Formula.


Intestinal Rejuvenation Formula (IRF) is a high-fiber powdered supplement designed to act as a sweep to cleanse and help detoxify the entire gastrointestinal (GI) tract. Dr. Hank Liers formulated it as an effective drawing, detoxifying, and healing formula for the bowel. Within the HPDI supplement system, the formula is considered a specific-condition formula for gut health. That is, it is not a foundational supplement or an enhancement formula.

intestinal rejuvenation formula

Dr. Hank Liers’ Intestinal Rejuvenation Formula cleanses, detoxifies, purifies, and heals.

Detoxification is one of the main components of the HPDI Rejuvenation Program. As such, the capacity of Intestinal Rejuvenation Formula to detoxify the bowel makes it an integral supplement in the program.

Intestinal Rejuvenation Formula is a gentle-acting formula that may be taken daily or as needed. It is easily integrated into a gut health routine or regimen. Regular use is warranted for individuals desiring to maintain gut health. It is also beneficial for periodic use, such as seasonal cleansing, reduced bowel function, or constipation. Yet, it offers many benefits for chronic issues such as bowel pockets, diverticulosis, and diverticulitis. Acute uses include applications for upset stomach, food poisoning, diarrhea, as well as topical use for insect or snake bites.

Intestinal Rejuvenation Formula contains ingredients that help it to cleanse by sweeping wastes and deposits from the GI tract (psyllium, pectin, bentonite), coat and soothe (slippery elm bark and marshmallow root), sequester toxins (fibers and activated charcoal), heal and rebuild the mucosa (vitamin C and CGF).


We live in an age where many environmental factors and lifestyle elements contribute to GI tract dysfunction. These include overuse of antibiotics and use of antibiotics in foods that destroy microbiome diversity. These elements also encompass agricultural toxins (e.g., glyphosate from RoundUp) used in growing GMO (genetically modified organisms) crops consumed in foods that contribute to weakening of tight junctions in the GI tract.

As such, it is imperative individuals take steps to restore proper function and rebuild gut health. Such steps may include consuming organic and non-GMO foods that neither contain herbicides like glyphosate nor GMOs.

In addition, overconsumption of wheat, simple carbohydrates, and sugars is a major element contributing to a pandemic of gut dysfunction. It is well known that wheat and other food crops containing gluten, gliadin, and related proteins readily contribute to GI tract problems among an ever increasing percentage of the population.

Books like William Davis’ Wheat Belly: Lose the Wheat, Lose the Weight, and Find Your Path Back to Health, and David Perlmutter’s Grain Brain: The Surprising Truth About Wheat, Carbs, and Sugar – Your Brain’s Silent Killers and Brain Maker: The Power of Gut Microbes to Heal and Protect Your Brain for Life, document the adverse effects caused by the consumption of wheat and refined carbohydrates on health, especially gut and brain health.

Wheat in particular is singled out due to its extensive hybridization, which has created a very different genetic profile for the grain (despite the fact that it has not yet been genetically modified on a large scale). This has created high-yielding wheat variants that can cause or contribute to adverse health effects, and have not been subject to safety testing.

Yet, it is known that glyphosate herbicide is routinely sprayed on non-GMO crops—like wheat, oats, and beans—as a drying agent to speed harvesting. Consuming non-GMO foods may not be sufficient to prevent ingestion of toxic glyphosate and therefore avoid its adverse GI tract effects. Consumers are best served by consuming certified organic, biodynamic, chemical-free, and/or home grown foods.

The increase in gut health issues among the population is reflected both in the dramatic rise of diabetes, celiac disease, obesity, and brain maladies (like Alzheimer’s and Parkinson’s Disease) in recent years.

The authors suggest that elimination or significant reductions in the consumption of wheat, sugar, and refined carbohydrates will go far in helping to improve and restore health. And that starts in the gut.

In addition to dietary changes and lifestyle modifications, a balanced fiber and gut-soothing formula like Intestinal Rejuvenation Formula can be part of a complete program to cleanse, heal, and rebuild the gut for improved GI tract function.

A complete program for gut health includes probiotics, which are the subject of various articles we have written that include recommendations for consuming dietary probiotics and probiotics, creating a probiotic-friendly lifestyle, as well as supplementing with probiotic formulas like Prescript-Assist.

Intestinal Rejuvenation Formula contributes to gut health differently than dietary or supplemental probiotics, yet is designed to work well with probiotics of all types to improve gut health. HPDI recommends a synergistic approach to gut health encompassing diverse approaches (and multiple products) combined to produce optimal results.


Intestinal Rejuvenation Formula cleanses the entire digestive tract by drawing toxins, clearing blockages, and supporting natural movement. It works by coating and adhering to the lining of the intestines. This unique action allows it to absorb fecal plaques and other debris, soften unhealthy deposits, and sweep them away for elimination in the stool.

Intestinal Rejuvenation Formula neutralizes and removes hundreds of toxins, including heavy metals (e.g., mercury and lead). It draws out many times its weight in material encrusted or trapped in the intestinal lining. It also provides nutrients known to nourish the GI tract, and that promote normal elimination functions.


Intestinal Rejuvenation Formula relieves symptoms of constipation, including gas, bloating, cramps, indigestion, and nausea caused by excessive waste in the bowel. It also soothes the intestinal lining and colon wall, and promotes a well-functioning colon. This means it can contribute to greater health not only through removal of toxins and intestinal blockages, but also by allowing greater absorption of nutrients from food (i.e., after the intestines are cleansed). It also can contribute to achieving normal weight by promoting elimination of old fecal matter (e.g., post-putrefactive deposits), and by helping to establish and maintain normal bowel function.


Intestinal Rejuvenation Formula acts as a wonderful soothing agent for the mucous membrane linings of the entire intestinal tract, especially the colon. This makes it an important formula for individuals experiencing irritable bowel syndrome, spastic colon, colitis, Crohn’s disease, diverticulitis, or any digestive tract condition causing hot, burning, irritated, or bleeding bowels and/or diarrhea. This unique healing formula is also an excellent remedy for food poisoning, because it can absorb harmful bacteria and toxins.


Due to its excellent detoxification and intestinal cleansing properties, Intestinal Rejuvenation Formula is ideal for use in periodic cleansing regimens, such as bowel cleansing, liver cleansing, kidney cleansing, or many types of juice cleanses, fasts, or flushes.

When using Intestinal Rejuvenation Formula as part of a short-term cleansing regimen (3–30 days), it can be used at higher levels, such as up to 1 tablespoon 3–5 times daily, as needed.

Note: After a cleansing regimen, it is useful to repopulate the gut with beneficial bacteria using a high-quality probiotic formula such as Prescript-Assist™ (soil-based organisms).


Another benefit of Intestinal Rejuvenation Formula is its ability to stop loose stools and diarrhea. This is especially important in cases of acute diarrhea in which dehydration and inability to assimilate nutrients from foods creates a problem for health.

As noted, Intestinal Rejuvenation Formula helps regulate bowel function. It therefore can help constipated individuals become more regular. However, in cases of diarrhea, it can fill the GI tract with sufficient bulk (fiber) to slow the rate of excretion, as well as help prevent dehydration due to fluid loss.

Because of the safety and efficacy of Intestinal Rejuvenation Formula, it is also safe for use with children and pets. Be sure to give with sufficient water and scale down the dose appropriately depending on the size of a child or pet.


Intestinal Rejuvenation Formula contains psyllium husk powder (organic), cold-milled flax seed powder (organic), apple pectin, bentonite clay (wildcrafted), marshmallow root powder (organic), slippery elm bark powder (organic), activated willow charcoal (wildcrafted), inulin / fructooligosaccharides (from chicory root), ginger root powder (organic), natural lemon flavoring, Vitamin C (from magnesium ascorbate), malic acid, grape extract (pulp, skin, and seed), licorice root powder (organic), stevia leaf extract (97% rebaudioside A), magnesium (from magnesium ascorbate), and chlorella growth factor (CGF).

INGREDIENTS: One teaspoon (3.23 gram) provides the following nutrients:

Psyllium Husk Powder (organic) – 1,000 mg
Apple Pectin – 400 mg
Bentonite Clay (wildcrafted) – 400 mg
Cold-Milled Flax Seed Powder (organic) – 400 mg
Marshmallow Root Powder (organic) – 200 mg
Slippery Elm Bark Powder (organic) – 200 mg
Activated Willow Charcoal (wildcrafted) – 100 mg
Spirulina Pacifica – 100 mg
Inulin / Fructooligosaccharides (from Chicory Root) – 100 mg
Ginger Root Powder (organic) – 100 mg

Natural Lemon Flavor – 100 mg
Vitamin C (from magnesium ascorbate) – 60 mg
Malic Acid – 50 mg
Grape Extract (pulp, skin, & seeds) – 40 mg
Licorice Root Powder (organic) – 40 mg
Stevia Leaf Extract (97% Rebaudioside A) – 13 mg
Magnesium (from magnesium ascorbate) – 4.5 mg
Chlorella Growth Factor (CGF) – 4 mg

The nutrients contained in Intestinal Rejuvenation Formula are all known to provide unique therapeutic benefits and healing properties. Consequently, the formula is carefully designed so the ingredients work together synergistically to leverage and maximize the capacities of each one. This results in a formula that is superior in action and that can far more effectively support health and healing in the intestinal tract than single ingredients or shotgun approaches (that often result in reduced effectiveness through the use of fillers, imbalanced formulation, or less than the highest quality ingredients).

Intestinal Rejuvenation Formula is a superior formulation representing a higher level of design expertise. This unique formula can offer significant benefits and results for individuals who wish to improve, regenerate, rejuvenate, heal, and sustain excellent gastrointestinal health.

gut health intestinal rejuvenation formula

Ginger is an ingredient known to support gut health.


Psyllium seed husks are soluble in water, expanding and becoming mucilaginous when moistened. Psyllium seed husks are indigestible in human beings and are used as a source of dietary fiber. They are used to relieve constipation, irritable bowel syndrome, diverticular disease, and diarrhea. They are also used as a regular dietary supplement to improve and maintain regular gastrointestinal (GI) transit.

The inert bulk of psyllium husks helps to provide a constant volume of solid material regardless of other aspects of the diet or any disease condition of the gut. Recent research also shows psyllium seed husks to be promising in lowering cholesterol and controlling diabetes.


As a dietary fiber, apple pectin is helpful in maintaining good digestive health. Pectin forms a colloidal solution in water and gels when cool. An indigestible, soluble fiber, apple pectin is a general intestinal regulator used in many healing preparations, especially as an anti-diarrheal agent. Researchers at the University of California, Davis (UCD), found that apple pectin acts as an antioxidant against the damaging portion of cholesterol in the blood stream.

It has been established that a diet rich in apple pectin may help protect against certain diseases. Research in Japan shows that apple pectin can act as a chemopreventive agent. Apple pectin helps maintain intestinal balance by cleansing the intestinal tract with its soluble and insoluble fibers.

Apple pectin tends to increase acidity in the large intestines and is advocated for those suffering from ulcer or colitis and for regulating blood pressure. Pectin is also effective in causing regressions in and preventing gallstones. There is also evidence that the regular use of apple pectin may lessen the severity of diabetes.

Apple pectin is known to draw radiation from the body. Russian doctors have found apple pectin to be among the most effective means for protecting against radiation when consuming contaminated foods is unavoidable. Pectin, along with vitamins and minerals, eliminates radionuclides ingested from foods. This is especially relevant given recent meltdowns and radiation releases from the nuclear complex in Fukushima, Japan. Radiation from this catastrophe has contaminated (and continues contaminating) food crops across the entire northern hemisphere (and beyond), especially crops grown in North America.


Bentonite clay has a large and varied mineral content, including over 50 minerals. Seen under a high powered microscope, bentonite is composed of extremely minute rectangular particles. The wide surfaces are negatively charged and the edges are positively charged. Therefore, its adsorptive power is many thousand times more negative than positive. It has a negative electrical attraction for positively charged particles. In the human body, various toxic poisons are positively charged. The very minuteness of the particles give it a large surface area (about 1,000 square meters per gram) relative to its volume, thereby enabling it to pick up many times its own weight (as high as 40 times) in positively charged particles.

When bentonite clay absorbs water and swells, it stretches open like a highly porous sponge. Toxins (including pathogenic viruses, herbicides, and pesticides) are drawn into these spaces and bound through electrical attraction. The bentonite is eventually eliminated from the body with the toxins bound to its multiple surfaces. Diarrhea can be remedied through the use of bentonite clay because of its capacity to bind stools. Bentonite clay can act immediately to bind irritants in the gastrointestinal tract.

COLD-MILLED FLAX SEEDS (organically grown)

Flax seeds (Linum usitatissimum L.) contain essential fatty acids (an excellent vegetarian source of omega-3 alpha-linolenic acid), protein, soluble fiber, insoluble fiber, antioxidant lignans, minerals, and vitamins. Lignans are a phytoestrogens considered to be antioxidants. Flax seeds contain among the highest levels of lignans among all plant foods.

The unique properties of Heartland’s RCM™ Flax (Real Cold Milled) organic flaxseed provides enormous advantages over whole flax seeds, ground flax powders, and other milled flax seed products. In particular, cold-milled flax seeds offer readily assimilable omega-3 and omega-6 fatty acids because of special no-heat processing that protects these delicate oils and makes them available for uptake into the body.

RCM™ Flax cold-milled flaxseed is processed using a unique, proprietary method that preserves the delicate oils and allows for optimal uptake of the oils and other nutrients (e.g., soluble fiber) into the body. That is, flax seeds must be milled into a flour or meal to obtain maximum benefits from its oils and dietary fiber. However, typical methods of grinding or pounding flaxseeds separate the oil from the seeds (and heat the oils), thereby causing the oils to oxidize and become rancid.

In contrast, cold milling is a unique process that does not involve heating delicate oils and keeps them protected within finely milled pieces of seed. Thus, cold-milled flax seed is not significantly oxidized and remains fresh for an extended period of time. Conversely, when flax seeds are harshly ground or crushed, the oils do not remain fresh because there is no inherent protection from oxidation. Cold milling allows the seed to retain and protect its oils because the process does not release the oils from the seeds .

RCM™ Flax offers a non-refrigerated shelf life of greater than 24 months. A study conducted at North Dakota State University confirms that peroxide levels of RCM™ Flax remain exceptionally low for an extended periods. While this flaxseed retains its freshness for an extended period, when refrigerated (or consumed within several months), it provides amazingly high levels of freshness.

The organic cold-milled flax seeds in Intestinal Rejuvenation Formula contain oil amounts varying between 38–45%, with the oil offering a high percentage (47–53%) of the omega-3 alpha-linolenic acid (ALA) and 15-18% omega-6 linoleic acid. Alpha-linolenic acid (ALA) is an essential fatty acid acting in the human body as a substratum for the transformation into EPA and DHA through the action of desaturation and elongation enzymes. The seeds also contain some omega-6 essential fatty acids and exhibit a favorable omega-3 to omega-6 ratio of 3:1. Modern diets contain too few omega-3 fatty acids.

Cold-milled flax seeds possess 15–30% protein (typically 20%) and the amino acids of flax protein have no limiting factors in the adult diet (i.e., they are a complete protein source having all of the essential amino acids in an appropriate balance). Flax seeds are also a source of magnesium, calcium, potassium, phosphorus, zinc, and copper. They also have demonstrated antioxidant activity.

The most important antioxidants flax seeds provide are phytoestrogens known as lignans. Because cold milling flax seeds significantly reduces oxidation, this exceptional flax seed has great potential within the food industry when compared to other alpha-linolenic acid sources, such as typical ground flaxseed powders, which can exhibit rapid decomposition due to a lack of antioxidant protection from oxidation.

The human body easily digests flax seeds. The seed’s outer layer is rich in mucilloid soluble fiber (flax seed possesses 10-15% soluble fiber) and absorbs at least 4 times its weight in water. When mixed with water or stomach juices, the seeds form a gel that creates a physical barrier between the carbohydrates and the digestive enzymes that break them down. The carbohydrates thereby are digested and converted into glucose (blood sugar) at a slow, uniform rate. There is no insulin surge or spike needed to lower the blood sugar level. The water-retaining capacity of the gel also maintains bodily hydration (i.e., helping level out water intake) and electrolyte balance.


Considered the king of mucilaginous (gel-like) slippery plants, marshmallow offers a unique composition of about 37% starch, 11% mucilage, and 11% pectin (including flavonoids and phenolic acids). When it reaches the colon, marshmallow gel will soften hardened fecal plaques and help to remove them from colon walls. It also acts as a soothing coating and internal moisturizer for the entire digestive tract. Like chia seeds, it neutralizes irritants often found in the intestinal system, and thereby greatly relieves irritation to the mucous membrane lining of the digestive tract.


The health benefits of slippery elm are rooted mainly in its soothing properties. This mucilaginous herb is effective when used internally for coating and soothing mucous membranes while also absorbing toxins that can cause intestinal imbalances. Slippery elm is an effective remedy for duodenal ulcers, gastritis, diarrhea colitis, irritable bowel syndrome, hemorrhoids, and heartburn. The benefits of slippery elm also extend to being a simple food. As part of a normal diet, the inner bark of slippery elm can be ground and eaten as porridge. This porridge is extremely nutritious and high in antioxidants having a consistency and taste similar to oatmeal. It is also a wholesome and sustaining food for infants and invalids.


Activated charcoal is charcoal that has been treated with oxygen to open up millions of tiny pores between the carbon atoms. The use of special manufacturing techniques results in highly porous charcoals that have surface areas of 300–2,000 square meters per gram. Charcoal works to trap toxins through “adsorption.” When a material adsorbs something, it attaches to it via chemical attraction. The huge surface area of activated charcoal gives it countless bonding sites for adsorbing toxins.

When certain chemicals pass next to the carbon surface, they attach to the surface and become trapped. Activated charcoal is excellent for trapping carbon-based substances (i.e., organic chemicals), as well as other chemicals such as chlorine. It is known to trap over 20,000 organic chemicals. Many chemicals are not attracted to carbon (sodium, nitrates, etc.) so they pass through charcoal. Because charcoal is not “digested” like food, it may remain inside the GI tract for a time, thereby continuing to actively remove toxins via the bowel.


Research has shown that spirulina promotes digestion and bowel function. It suppresses bad bacteria (including E. coli and Candida albicans yeast) and stimulates beneficial flora, including lactobacillus and bifidobacteria. Healthy intestinal flora (i.e., “good” bacteria) are a foundation for good health. They increase absorption of nutrients from foods and help protect against infection. In Japan, researchers found that spirulina significantly reduces kidney toxicity caused by mercury and three pharmaceutical drugs. This suggests benefits for humans suffering heavy metal poisoning. Additional research found that rats consuming spirulina or chlorella algae eliminated seven times the amount of dioxin (a highly toxic chemical) when compared to a control diet.


Like other types of dietary fiber, inulin also has the benefits of enhancing digestive and intestinal functions, reducing cholesterol, and preventing disease. In addition, inulin has one other major health benefit: it is a prebiotic that feeds the healthy microflora that boost your immunity. Not only does inulin actively promote the growth of existing strains of probiotics in your colon, but it also encourages implantation, survival, and growth of freshly consumed probiotics. By boosting the survival and growth of beneficial probiotics in the inner ecosystem, inulin improves digestion, immunity, and disease-fighting capacity of the body.


Ginger rhizome (Zingiber officinale) is an incredibly active and effective gastrointestinal aid with the following properties: 1) Contains a digestive enzyme whose effectiveness even exceeds that of papain; 2) Stimulates the flow of saliva and increases the concentration of the digestive enzyme amylase in the saliva; and 3) Activates peristalsis and increases intestinal muscle tone. Ginger is also known to be helpful in cases of nausea.


BIOVIN® Grape Pulp, Skin & Seed Extract (>85% OPCs): The BioVin® grape extract in Intestinal Rejuvenation Formula is extracted by ethanol and water and contains the highest percentage of OPCs of any product on the market. OPCs, a class of bioflavonoids, are one of nature’s most powerful free-radical scavengers. As bioflavonoids, OPCs help to increase the effectiveness of Vitamin C. OPCs cross the blood-brain barrier to provide antioxidant protection to central nervous system tissue. Studies have clearly demonstrated that OPCs improve and normalize capillary activity, strengthening capillary walls. OPCs bind to collagen fibers, realigning them in the process to a more youthful, undamaged structure. Elasticity, flexibility, and strength are thereby restored to connective tissue.


Licorice root soothes the GI tract and aids intestinal health. Licorice root is used effectively in those individuals suffering from peptic ulcer and chronic gastritis. It is used to soothe coughs and reduce inflammation, soothe and heal ulcers and stomach inflammation, control blood sugar, and to balance hormones. Licorice is a potent antiviral agent and can be used to treat flu, herpes, and even hepatitis. Licorice is also a strong anti-inflammatory agent.

MAGNESIUM (from magnesium ascorbate)

Magnesium is important for the metabolism of many biologically active nutrients and substances, including calcium, potassium, phosphorus, zinc, copper, sodium, lead, cadmium, hydrochloric acid (HCl), acetylcholine, and nitric oxide (NO). It is required for more than 325 magnesium-dependent enzymes, cellular homeostasis, and activation of the B vitamin thiamin. It mediates the functions of the nervous and endocrine systems, supports proper muscle and nerve function, stabilizes heart rhythm, helps to regulate blood sugar levels, and supports normal blood pressure. Magnesium is important in energy metabolism and the synthesis of proteins.


Chlorella Growth Factor (CGF) stimulates lactobaccilus (the “good” bacteria) to grow at four times the usual rate. Experiments with microorganisms, young animals, and children have demonstrated that CGF promotes faster than normal growth. In adults and mature organisms, CGF appears to enhance the functions of nucleic acids at the cellular level that relate to the production of proteins, enzymes, and energy. It also stimulates tissue repair and offers protection against toxic substances at the cellular level.

VITAMIN C (from magnesium ascorbate)

Vitamin C is known to perform many critical functions within the body involving detoxification, tissue building, immune enhancement, pain control, and controlling or killing pathogenic organisms. It is known to be helpful for wound and bone healing, healthy skin and eyes, infections, stress control, toxic exposure, and repairing damaged tissue of all types.


Additional Ingredients: Natural Lemon Flavor, Malic Acid, and Stevia Leaf Extract. These natural flavors and taste enhancers give the formula a pleasing taste and make it easier for individuals to consume.

DIRECTIONS: For long term, gentle rejuvenation of the intestinal tract take about one (1) teaspoon (about 1/3 scoop) several times daily away from food (by at least 20 minutes), or as directed by a health care professional. Place the powder in about 8 ounces of water, thoroughly mix (shake or stir), and drink immediately (before the formula becomes a gel too thick to easily consume).

For a more rapid healing cleanse take one tablespoon (one scoop) multiple times daily away from food (by at least 45 minutes). Add the powder to about 16 ounces of water, mix vigorously, and drink.

We recommend using a suitable container (such as a mason jar) for rapid mixing. Stir rapidly or shake vigorously (with lid attached).

Individuals suffering from conditions of severe diarrhea and loose stools can take one tablespoon (or more) multiple times daily (five times or more) and refrain from food. Put the powder in about 16 ounces of water per tablespoon, thoroughly mix, and drink immediately. In between servings it may be helpful to take 10–20 billion organisms of a multiple strain lactic acid bacteria formula (i.e., a probiotic such as Prescript-Assist). Place the formula directly in your mouth, chew, and then swallow.

While results can be obtained rapidly using this formula, it is most effective when used for longer-term gentle cleansing. Starting with lower doses and gradually increasing dosage often produces best results. This allows the body time to adjust to increased dosages (size and frequency) and facilitates greater therapeutic action from usage.

Note: Taking large amounts without sufficient liquid (e.g., water) or when first taking the formula can slow bowel transit time. Therefore, most individuals will benefit from starting at lower dosage levels and ensuring adequate fluid intake when consuming the formula.

External Applications: Make paste by mixing powder with water. Apply directly to skin or affected areas (e.g., stings, bites, wounds). Wrap with gauze, plastic, etc., and keep poultice moist. Use for up to six hours. Apply fresh poultice as needed. For more information, see the Insect / Bee / Snake Stings and Bites Supplement and Activity Schedule.

Intestinal Rejuvenation Formula does not contain wheat, gluten, rye, oats, corn, barley, soy, yeast, egg, sugar, dairy products, GMOs, wax, animal fats, preservatives, colorings, or artificial flavorings.

intestinal rejuvenation formula specific condition doctor liers original

Intestinal Rejuvenation Formula is an effective, specific-condition formula for gut health.


“Health begins in the gut,” the saying goes. If true, and it seems likely to be, then taking care of the GI tract is more important than ever. This makes sense given the prevalence and multiplication of environmental and lifestyle factors capable of damaging the gut.

These environmental and lifestyle factors include, but are not limited to, 1) the use of antibiotics (both prescribed and found in foods), 2) genetically modified organisms (GMO), 3) the presence in foods (and water, soil, and air) of herbicides like glyphosate sprayed on GMO crops; glyphosate can loosen tight junctions in the GI tract to allow food proteins into the bloodstream, 4) Food proteins (e.g., gluten and gliaden) capable of damaging the gut, 5) dysbiosis, 6) lack of microbiome diversity, and 7) many others.

The solution to these problems is complex, and partly resides in utilizing a combination of strategies and supplements capable of addressing the different aspects and causes of reduced or impaired gut function.

Intestinal Rejuvenation Formula represents one type of supplement known to be helpful in repairing, restoring, and maintaining healthy gut function.


“Intestinal Rejuvenation Formula works well for cleansing. It also helped stop runny stools I had after eating out while traveling.” – T.T., Seattle, WA




Dr. Mark Sircus’s blog article at www.DrSircus.com:
“Apples – Pectin – Intestinal Formula”

Kidney Cleansing with Juices & Herbs

Liver Cleanse with Juices & Herbs

Rejuvenation Program: Part 2 (Detoxification)

Death by One (Or Two) Thousand Cuts

Microbiome, Diet, and Prescript-Assist Probiotic and Prebiotic

Super Remedies for Stings and Bites

Understanding Glyphosate Toxicity: Interview with Genetic Engineer Thierry Vrain (Mother Earth News)


Brain Maker: The Power of Gut Microbes to Heal and Protect Your Brain for Life by Dr. David Perlmutter

Grain Brain: The Surprising Truth About Wheat, Carbs, and Sugar – Your Brain’s Silent Killers by Dr. David Perlmutter

Wheat Belly: Lose the Wheat, Lose the Weight, and Find Your Path Back to Health by Dr. William Davis



PRESCRIPT-ASSIST™ Probiotic Formula (soil-based organisms)

RESTORE For Gut Health (lignite formula)

(proteolytic enzymes)

(full spectrum plant enzymes)

Nascent Iodine

Magnesium Oil, Flakes, Gel



Dr Hank Liers PhD restore gut healthI have been excited about the ongoing research concerning the human biome ever since preparing my blog article entitled “A New View of the Role of Bacteria in Health” in June of 2012.

I was particularly impressed by a TED talk of Dr. Bonnie Bassler concerning how bacteria communicate with each other (“Discovering Bacteria’s Amazing Communication System“) on TED.com.

I came away from Dr. Bassler’s talk with a new understanding of who we are and how we are influenced by bacteria. The fact that our bodies house ten times the number of bacteria than the number of cells in our bodies and 100 times the amount of DNA compared to our human DNA is very impressive!! Of particular note was the fact that bacteria conduct both intraspecies and interspecies communication using carbon-based hormones.


Since that time my company switched to a soil-based organisms (SBO) probiotic formula called Prescript-Assist as our main probiotic formula. The formula includes a “prebiotic” called leonardite.

Leonardite is a natural form of humates that is completely organic in nature and provides ideal conditions for “good” bacteria to grow. It is a soft, waxy, black or brown, shiny, vitreous mineraloid that is easily soluble in alkaline solutions.

Leonardite is an oxidation product of lignite, a soft, brown combustible sedimentary rock formed from naturally compressed peat. Lignite has a carbon content of 25–35% and embedded in the carbon are special carbon-based molecules that were produced by soil bacteria millions of years ago.

The amazing part of this story is that Dr. Zachary Bush—a medical doctor with extensive experience in cancer research and mitochondria chemistry—made an accidental and instant connection between the special carbon molecules of lignite and special redox molecules found in mitochondria.

Based upon his recognition of these similar molecules, he developed a formula using the lignite bacterial produced carbon molecules. He found that by adding certain trace minerals and amino acids under special conditions these carbon molecules were activated.

Upon giving his formula to human beings, Dr. Bush discovered dramatic and rapid increases in beneficial gut bacterial counts. That is, the human microbiome was significantly affected in a positive way. This is particularly important since it is known that the human gastrointestinal tract houses about seventy percent of our immune system.

restore gut health

The most amazing part of the story was then discovered. That is when the formula (called RESTORE) was given, the tight junctions in the gut were restored to their optimal condition and “leaky gut” disappeared.

What makes this discovery so special is that “leaky gut” is caused by certain toxic bacteria, gluten, antibiotics, medical anti-inflammatories, and especially the herbicide glyphosate (RoundUp) used for genetically modified (GMO) food crops. This “leaky gut” condition is endemic in our society and getting worse as we continue to take in these toxic substances in ever increasing amounts. In Dr. Bush’s experience with a very broad range of conditions, healing began to occur very quickly when RESTORE is taken.

Additionally, Dr. Bush found that when the tight junctions in the gut were restored to their optimal condition, all of the other tight junctions in the body were restored as well. These include tight junction in the blood brain barrier, the kidney tubules, blood vessels, etc. As a result many conditions in the body dramatically improved.

Dr. Bush discovered that almost all conditions of poor health are caused by chronic inflammation and he has stated that chronic inflammation is caused by a lack of communication within the cells of the body. He has clearly seen that RESTORE reinstates proper communication between the cells and greatly reduces inflammatory conditions!

HOW EXCITING!!! Based upon this almost unbelievable discovery we have decided to carry RESTORE in both 32 oz and 8 oz sizes on our retail website. We take it ourselves!!!

To learn more about RESTORE and its discovery listen to this talk by Dr. Bush.


Contact Us:

You can reach HPDI by calling 1-800-228-4265, email support(at)IntegratedHealth.com, or visit the retail website: www.IntegratedHealth.com

Health care professionals and retailers can apply for wholesale account, which includes access to the HPDI reseller website: www.HealthProductsDistributors.com



Fred Liers PhD molecular hydrogen H2I drink hydrogen-infused water. You should, too. Why? Because the age of hydrogen is here. Molecular hydrogen, that is. We now know that molecular hydrogen has therapeutic potential for nearly every organ in the human body, as well as for 150 different human disease models! And it’s extremely safe.


Molecular hydrogen, also known as “diatomic hydrogen,” is a colorless, tasteless, and odorless gas.

Elemental hydrogen (H) is the most abundant element in the universe constituting 75% of its mass. Yet, it is absent on earth in its monoatomic form, being present in water, and inorganic and organic compounds. Molecular hydrogen is found in the earth’s atmosphere at less than one part per million.

molecular hydrogen H2 water

Hydrogen-infused water is a simple means to consume molecular hydrogen.

The science regarding benefits to health of molecular hydrogen (H2) has advanced rapidly in recent years thanks to the pioneering efforts of research scientists around the globe.

Now hydrogen science is moving quickly beyond theory to practical applications. Moreover, new products exist allowing medical professionals and consumers to leverage the health benefits of hydrogen.

For decades, diatomic molecular hydrogen was generally considered an “inert” gas. That is perhaps the primary reason that molecular hydrogen has been recognized as a therapeutic molecule only recently.

Indeed, science has known about the health benefits of molecular hydrogen as early as 1798. Yet, as noted, for most of modern history the belief persisted that hydrogen was inert in the body. It was only in the late 20th century (ca. 1975) that it gained the attention of medical researchers, and only in the past 10 years has evidence for the health effects of molecular hydrogen gained critical mass in the scientific literature.

There are now more than 500 peer-reviewed articles demonstrating the therapeutic potential of hydrogen for nearly every organ in the human body, as well as in 150 different human disease models, according to the Molecular Hydrogen Foundation.


• Molecular hydrogen reduces oxidative stress as a selective antioxidant and by maintaining homeostatic levels of glutathione, superoxide dismutase, catalase,  and other free-radical scavenging nutrients.

• The antioxidant capacities of molecular hydrogen are such that it is beneficial for persistent and acute oxidative stress.

• Acute oxidative stress arises from a multitude of causes, including inflammation, cardiac or cerebral infarction, organ transplantation, heavy exercise, cessation of operative bleeding, and many other causes.

• Persistent oxidative stress relates to reactive oxygen species (ROS) generated in the body throughout life. For example, during exercise, exposure to pollutants and toxins or UV light, as well as physical and psychological stresses, and the aging process itself. As aerobic organisms, we generate ROS when breathing consumes oxygen.

• Molecular hydrogen is effective against hydroxyl radicals (OH). The hydroxyl radical is the radical species that causes much of the oxidative damage in the body. While vitamin C, glutathione, and certain plant-based antioxidants are somewhat effective against this radical, there is no Nrf2-induced enzyme that effectively quenches the hydroxl radical.

• This positions molecular hydrogen as a uniquely effective antioxidant against the hydroxyl radical. Notably, when molecular hydrogen quenches the hydroxyl radical, it produces water, which is non-toxic in the body.

• Beyond this, molecular hydrogen, like other gaseous signaling molecules such as NO, CO, H2S, appears to exhibit cell signal-modulating activity that confers it with anti-inflammatory, anti-obesity, anti-allergy, and many other benefits.


The scientific literature discusses the use of molecular hydrogen for many clinical applications, including the following:

• METABOLIC SYNDROME including diabetes, hyperlipidemia, arteriosclerosis, hypertension, and obesity

• ISCHEMIA / REPERFUSION injuries including cerebral and myocardial infarctions, organ transplants, post-cardiac arrest

• NEUROPROTECTION including applications for dementia, Parkinson’s disease, depression, and anesthesia

• INFLAMMATION including applications for polymicrobial sepsis, rheumatoid arthritis, wound healing, and bowel diseases



• AGING including cognitive decline

• EXERCISE including applications for fatigue, lactic acid, recovery, and oxidative stress related to heavy exercise

SIDE EFFECTS OF CANCER THERAPIES including radiotherapy and chemotherapy


athlete molecular hydrogen performance race

Athletes benefit from molecular hydrogen. You can, too.


According to the Molecular Hydrogen Foundation, there are three ways molecular hydrogen exerts positive health effects.

1.  Molecular hydrogen easily diffuses into subcellular compartments where it scavenges cytotoxic oxygen radicals, thereby protecting DNA, RNA, and proteins against oxidative stress.

2.  Molecular hydrogen triggers activation or upregulation of additional antioxidant enzymes (e.g., glutathione, superoxide dismutase, catalase, and others) and/or cytoprotective proteins of the body.

3.  Molecular hydrogen may be a novel signaling molecule that alters cell signaling, cell metabolism, and gene expression. This may explain its apparent anti-inflammatory, anti-allergic, and anti-apoptotic (or anti-cell death) effects.


Molecular hydrogen exhibits great safety, and it is regarded as safe for use in the body. It is shown no toxicity even in high concentrations.

Safety standards are already established for high concentrations of molecular hydrogen for inhalation because high-pressure H2 gas is used in deep-water diving gas mixtures to prevent decompression sickness.

Notably, H2 gas combusts only at temperatures higher than 527 °C, and it explodes by chain reaction with oxygen (O2) only in the range of Hconcentration (4–75%, vol/vol).

Molecular hydrogen can be used for medical applications safely by several ingestion methods including inhalation of 1–4% hydrogen gas, which exhibits great effectiveness.

All these factors mean that molecular hydrogen is safe, easy-to-use, and effective for therapeutic purposes.

molecular hydrogen H2 water

Hydrogen-infused water is safe, easy-to-consume, and cost effective.


Methods for consuming molecular hydrogen include inhalation, oral ingestion of hydrogen-infused water, injection of hydrogen saline, and direct diffusion (eye drops, baths, cosmetics, etc.).

An advantage of inhaled H2 gas is that is acts rapidly. In this respect, may be suitable for defense against acute oxidative stress.

It has been shown that inhalation of 3–4% hydrogen (H2) gas reaches a plateau at approximately 10–20 μM in the arterial and venous blood in about 20 minutes. This is shown not to affect any physiological parameters (e.g., blood pressure), suggesting no adverse effects.

According to the Molecular Hydrogen Foundation, the consensus is that drinking H2-rich water is the easiest, and often the most effective, method for obtaining molecular hydrogen although it does not provide as many hydrogen molecules to the body as other methods.

Some studies show consuming H2-infused water to be more effective than inhalation or increasing intestinal H2 production via lactulose administration.

Another advantage of drinking hydrogen infused water is that it allows gastric induction of ghrelin, which is mediated via activation of beta 1 adrenergic receptors.

Above all, drinking hydrogen-infused water is easy to do, and convenient as you can drink it at home or while traveling.


Inhalation of molecular hydrogen gas may be impractical for continuous H2 consumption in daily life. In contrast, solubilized H2 (hydrogen-infused water) is a portable, easily administered, and safe means to ingest H2.

H2 can be dissolved in water up to 0.8 mM (1.6 mg/L) under atmospheric pressure at room temperature without changing pH.

Hwater can be made by several methods: infusing H2 gas into water under pressure, electrolyzing water to producing H2, and reacting magnesium metal or its hydride with water.

Notably, H2 penetrates glass or plastic walls of vessels in a short time, yet aluminum containers retain hydrogen gas for a long time.

Water ionizers produce hydrogen gas via electrolysis. This method produces hydrogen concentrations from less than 0.05 ppm to more than 2.5 ppm. Typically 0.1 to 0.7 ppm hydrogen is produced, yet most companies manufacturing water ionizers neither know the concentration produced nor understand the significance of hydrogen for health.

In this regard, depending upon the production method much of the water containing molecular hydrogen exhibits a negative oxygen reduction potential (ORP). Yet, ORP is only a general indication of hydrogen production and is not a measurement of its concentration.

A second method of producing hydrogen-rich water by electrolysis is by infusion. In this method, hydrogen is directly infused into filtered water within a machine.

Another convenient method to generate molecular hydrogen is to add alkali-earth metals to water. Magnesium metal in commonly used for this purpose. This method allows for the production of high concentrations of molecular hydrogen that are generally near saturation (1.6 ppm), and therefore less water needs to be consumed by individuals drinking it.

Magnesium sticks and tablets/capsules are available (some of which are placed in water and others that can be consumed directly) that rapidly produce 2–4 ppm molecular hydrogen concentration. Like electrolysis, adding metals to water also increased the pH of water because they reduce the concentration of H+ ions.

Other methods exist that can produce supersaturated concentrations of molecular hydrogen with or without alteration of water pH. Advantages of these methods include having to drink a fraction of the amount of water in order to obtain an equal amount of molecular hydrogen.

Drinking water containing molecular hydrogen is probably the easiest and most cost-effective means for most persons to obtain hydrogen.

man drinks water infused with molecular hydrogen

Hydrogen-infused water can be consumed using tablets, prepared H2 beverages, or ionized water.


Certain types bacteria in the intestinal tract produce hydrogen gas from non-digestible fibers, which may explain how fiber-rich diets reduce inflammation, and exert cardiovascular and other health benefits.

Diets low in dietary fiber from fruits and vegetables, or a decrease in microbiome diversity could potentially reduce production of molecular hydrogen. This could exert adverse effects on health.

The presence (or absence) of a diverse and robust microbiome may be one of the most significant factors in terms of how much hydrogen can be generated in the body. Most people today do not create the levels of molecular hydrogen in their digestive tracts that humans in earlier time periods generated largely because due to modern diets and less than optimal microbiome health.

Factors that influence or reduce microbiome health and diversity include antibiotic use, imbalanced diet, lack of certain fiber-rich vegetables in the diet, and consumption of herbicides, pesticides, and GMOs (that include glyphosate) that harm microbial populations and cause “leaky gut”.

As knowledge increases regarding ways we can support a healthy microbiome, the biological significance of hydrogen historically produced in our digestive tracts will be better understood.


The clinical applications of molecular hydrogen are impressive. One of the great advantages of molecular hydrogen infused water is that  it is easy to consume it, or make it in your own home or wherever you happen to be.

HPDI now sells a tablet hydrogen product from Purative known as Active H2.

Active H2 is a unique, patent-pending combination of all-natural minerals used to generate molecular hydrogen and electron-rich potential (-ORP). This distinguishes it from existing hydrogen formulas and electrolysis (water ionizers).

Active H2 is easy to use.  Simply place one tablet of in a 1/2 liter (16 oz) container of pure water (filled to the top) and close tightly. Wait at least 5–10 minutes for it to completely disintegrate (fizz), and then drink.

A one pint glass mason jar works well as a container for this purpose. However, you can use up to one liter (about 32 ounces) of water in a container, so a quart mason jar also works well. Consume the hydrogen-infused water ideally at least 30 minutes before food.

Active H2 formula consists of a proprietary blend of pure magnesium, malic acid, fumaric acid, and maltose that synergistically act to generate molecular hydrogen and electron-rich potential (-ORP).

Active H2 is the only all-natural add-in tablet providing molecular hydrogen in the amount of greater than 1.8 ppm, That is, one tablet typically generates molecular hydrogen in the concentration of about 2 ppm.

There are other molecular hydrogen products, including tablets, sticks, and pre-infused bottled products like H2Bev. H2Bev provides about 1.2–1.5 ppm of molecular hydrogen and comes in a 12 oz coated aluminum container for excellent H2 retention.


Molecular hydrogen sits in the unique position of providing significant, wide-ranging benefits for health with an unmatched ease-of-use, and at relatively low cost for what it delivers.

We highly recommend the use of molecular hydrogen for its health benefits and for therapeutic applications. This includes the consumption of hydrogen-infused water whether from prepared H2 beverages, water ionizers, or highly effective Active H2 tablets.

Below we include important scientific abstracts you may find helpful in understanding the benefits and applications of molecular hydrogen.



Beneficial biological effects and the underlying mechanisms of molecular hydrogen – comprehensive review of 321 original articles

From: http://www.ncbi.nlm.nih.gov/pubmed/26483953

Therapeutic effects of molecular hydrogen for a wide range of disease models and human diseases have been investigated since 2007. A total of 321 original articles have been published from 2007 to June 2015. Most studies have been conducted in Japan, China, and the USA. About three-quarters of the articles show the effects in mice and rats. The number of clinical trials is increasing every year. In most diseases, the effect of hydrogen has been reported with hydrogen water or hydrogen gas, which was followed by confirmation of the effect with hydrogen-rich saline. Hydrogen water is mostly given ad libitum. Hydrogen gas of less than 4% is given by inhalation. The effects have been reported in essentially all organs covering 31 disease categories that can be subdivided into 166 disease models, human diseases, treatment-associated pathologies, and pathophysiological conditions of plants with a predominance of oxidative stress-mediated diseases and inflammatory diseases. Specific extinctions of hydroxyl radical and peroxynitrite were initially presented, but the radical-scavenging effect of hydrogen cannot be held solely accountable for its drastic effects. We and others have shown that the effects can be mediated by modulating activities and expressions of various molecules such as Lyn, ERK, p38, JNK, ASK1, Akt, GTP-Rac1, iNOS, Nox1, NF-κB p65, IκBα, STAT3, NFATc1, c-Fos, and ghrelin. Master regulator(s) that drive these modifications, however, remain to be elucidated and are currently being extensively investigated.

Molecular hydrogen as a preventive and therapeutic medical gas: initiation, development and potential of hydrogen medicine

From: http://www.ncbi.nlm.nih.gov/pubmed/24769081

Molecular hydrogen (H2) has been accepted to be an inert and nonfunctional molecule in our body. We have turned this concept by demonstrating that H2 reacts with strong oxidants such as hydroxyl radical in cells, and proposed its potential for preventive and therapeutic applications. H2 has a number of advantages exhibiting extensive effects: H2 rapidly diffuses into tissues and cells, and it is mild enough neither to disturb metabolic redox reactions nor to affect signaling reactive oxygen species; therefore, there should be no or little adverse effects of H2. There are several methods to ingest or consume H2; inhaling H2 gas, drinking H2-dissolved water (H2-water), injecting H2-dissolved saline (H2-saline), taking an H2 bath, or dropping H2-saline into the eyes. The numerous publications on its biological and medical benefits revealed that H2 reduces oxidative stress not only by direct reactions with strong oxidants, but also indirectly by regulating various gene expressions. Moreover, by regulating the gene expressions, H2 functions as an anti-inflammatory and anti-apoptotic, and stimulates energy metabolism. In addition to growing evidence obtained by model animal experiments, extensive clinical examinations were performed or are under investigation. Since most drugs specifically act to their targets, H2 seems to differ from conventional pharmaceutical drugs. Owing to its great efficacy and lack of adverse effects, H2 has promising potential for clinical use against many diseases.

Molecular hydrogen in drinking water protects against neurodegenerative changes induced by traumatic brain injury.

From: http://www.ncbi.nlm.nih.gov/pubmed/25251220

Traumatic brain injury (TBI) in its various forms has emerged as a major problem for modern society. Acute TBI can transform into a chronic condition and be a risk factor for neurodegenerative diseases such as Alzheimer’s and Parkinson’s diseases, probably through induction of oxidative stress and neuroinflammation. Here, we examined the ability of the antioxidant molecular hydrogen given in drinking water (molecular hydrogen water; mHW) to alter the acute changes induced by controlled cortical impact (CCI), a commonly used experimental model of TBI. We found that mHW reversed CCI-induced edema by about half, completely blocked pathological tau expression, accentuated an early increase seen in several cytokines but attenuated that increase by day 7, reversed changes seen in the protein levels of aquaporin-4, HIF-1, MMP-2, and MMP-9, but not for amyloid beta peptide 1-40 or 1-42. Treatment with mHW also reversed the increase seen 4 h after CCI in gene expression related to oxidation/carbohydrate metabolism, cytokine release, leukocyte or cell migration, cytokine transport, ATP and nucleotide binding. Finally, we found that mHW preserved or increased ATP levels and propose a new mechanism for mHW, that of ATP production through the Jagendorf reaction. These results show that molecular hydrogen given in drinking water reverses many of the sequelae of CCI and suggests that it could be an easily administered, highly effective treatment for TBI.

The evolution of molecular hydrogen: a noteworthy potential therapy with clinical significance

From: http://www.ncbi.nlm.nih.gov/pubmed/23680032

Studies on molecular hydrogen have evolved tremendously from its humble beginnings and have continued to change throughout the years. Hydrogen is extremely unique since it has the capability to act at the cellular level. Hydrogen is qualified to cross the blood brain barrier, to enter the mitochondria, and even has the ability to translocate to the nucleus under certain conditions. Once in these ideal locations of the cell, previous studies have shown that hydrogen exerts antioxidant, anti-apoptotic, anti-inflammatory, and cytoprotective properties that are beneficial to the cell. Hydrogen is most commonly applied as a gas, water, saline, and can be applied in a variety of other mediums. There are also few side effects involving hydrogen, thus making hydrogen a perfect medical gas candidate for the convention of novel therapeutic strategies against cardiovascular, cerebrovascular, cancer, metabolic, and respiratory diseases and disorders. Although hydrogen appears to be faultless at times, there still are several deficiencies or snares that need to be investigated by future studies. This review article seeks to delve and comprehensively analyze the research and experiments that alludes to molecular hydrogen being a novel therapeutic treatment that medicine desperately needs.

Molecular hydrogen as an emerging therapeutic medical gas for neurodegenerative and other diseases

From: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377272/

Effects of molecular hydrogen on various diseases have been documented for 63 disease models and human diseases in the past four and a half years. Most studies have been performed on rodents including two models of Parkinson’s disease and three models of Alzheimer’s disease. Prominent effects are observed especially in oxidative stress-mediated diseases including neonatal cerebral hypoxia; Parkinson’s disease; ischemia/reperfusion of spinal cord, heart, lung, liver, kidney, and intestine; transplantation of lung, heart, kidney, and intestine. Six human diseases have been studied to date: diabetes mellitus type 2, metabolic syndrome, hemodialysis, inflammatory and mitochondrial myopathies, brain stem infarction, and radiation-induced adverse effects. Two enigmas, however, remain to be solved. First, no dose-response effect is observed. Rodents and humans are able to take a small amount of hydrogen by drinking hydrogen-rich water, but marked effects are observed. Second, intestinal bacteria in humans and rodents produce a large amount of hydrogen, but an addition of a small amount of hydrogen exhibits marked effects. Further studies are required to elucidate molecular bases of prominent hydrogen effects and to determine the optimal frequency, amount, and method of hydrogen administration for each human disease.

Molecular hydrogen is a novel antioxidant to efficiently reduce oxidative stress with potential for the improvement of mitochondrial diseases

From: http://www.ncbi.nlm.nih.gov/pubmed/21621588


Mitochondria are the major source of oxidative stress. Acute oxidative stress causes serious damage to tissues, and persistent oxidative stress is one of the causes of many common diseases, cancer and the aging process; however, there has been little success in developing an effective antioxidant with no side effect. We have reported that molecular hydrogen has potential as an effective antioxidant for medical applications [Ohsawa et al., Nat. Med. 13 (2007) 688-694].

We review the recent progress toward therapeutic and preventive applications of hydrogen. Since we published the first paper in Nature Medicine, effects of hydrogen have been reported in more than 38 diseases, physiological states and clinical tests in leading biological/medical journals. Based on this cumulative knowledge, the beneficial biological effects of hydrogen have been confirmed. There are several ways to intake or consume hydrogen, including inhaling hydrogen gas, drinking hydrogen-dissolved water, taking a hydrogen bath, injecting hydrogen-dissolved saline, dropping hydrogen-dissolved saline into the eyes, and increasing the production of intestinal hydrogen by bacteria. Hydrogen has many advantages for therapeutic and preventive applications, and shows not only anti-oxidative stress effects, but also has various anti-inflammatory and anti-allergic effects. Preliminary clinical trials show that drinking hydrogen-dissolved water seems to improve the pathology of mitochondrial disorders.

Hydrogen has biological benefits toward preventive and therapeutic applications; however, the molecular mechanisms underlying the marked effects of small amounts of hydrogen remain elusive.

Hydrogen is a novel antioxidant with great potential for actual medical applications. This article is part of a Special Issue entitled Biochemistry of Mitochondria.

Recent progress toward hydrogen medicine: potential of molecular hydrogen for preventive and therapeutic applications

From: http://www.ncbi.nlm.nih.gov/pubmed/21736547

Persistent oxidative stress is one of the major causes of most lifestyle-related diseases, cancer and the aging process. Acute oxidative stress directly causes serious damage to tissues. Despite the clinical importance of oxidative damage, antioxidants have been of limited therapeutic success. We have proposed that molecular hydrogen (H(2)) has potential as a “novel” antioxidant in preventive and therapeutic applications [Ohsawa et al., Nat Med. 2007: 13; 688-94]. H(2) has a number of advantages as a potential antioxidant: H(2) rapidly diffuses into tissues and cells, and it is mild enough neither to disturb metabolic redox reactions nor to affect reactive oxygen species (ROS) that function in cell signaling, thereby, there should be little adverse effects of consuming H(2). There are several methods to ingest or consume H(2), including inhaling hydrogen gas, drinking H(2)-dissolved water (hydrogen water), taking a hydrogen bath, injecting H(2)- dissolved saline (hydrogen saline), dropping hydrogen saline onto the eye, and increasing the production of intestinal H(2) by bacteria. Since the publication of the first H(2) paper in Nature Medicine in 2007, the biological effects of H(2) have been confirmed by the publication of more than 38 diseases, physiological states and clinical tests in leading biological/medical journals, and several groups have started clinical examinations. Moreover, H(2) shows not only effects against oxidative stress, but also various anti-inflammatory and antiallergic effects. H(2) regulates various gene expressions and protein-phosphorylations, though the molecular mechanisms underlying the marked effects of very small amounts of H(2) remain elusive.

Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals

From: http://www.ncbi.nlm.nih.gov/pubmed/17486089

Acute oxidative stress induced by ischemia-reperfusion or inflammation causes serious damage to tissues, and persistent oxidative stress is accepted as one of the causes of many common diseases including cancer. We show here that hydrogen (H(2)) has potential as an antioxidant in preventive and therapeutic applications. We induced acute oxidative stress in cultured cells by three independent methods. H(2) selectively reduced the hydroxyl radical, the most cytotoxic of reactive oxygen species (ROS), and effectively protected cells; however, H(2) did not react with other ROS, which possess physiological roles. We used an acute rat model in which oxidative stress damage was induced in the brain by focal ischemia and reperfusion. The inhalation of H(2) gas markedly suppressed brain injury by buffering the effects of oxidative stress. Thus H(2) can be used as an effective antioxidant therapy; owing to its ability to rapidly diffuse across membranes, it can reach and react with cytotoxic ROS and thus protect against oxidative damage.


by Hank Liers, PhD (from the HPDI blog)

ACTIVE H2 (tablet product)

Molecular Hydrogen Foundation (MHF)

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Microbiome, Diet, and Prescript-Assist Probiotic & Prebiotic

Fred Liers PhD microbiome health probiotics prebioticsGut health is paramount to overall health. This was known in ancient times. According to the 4th-century (BCE) Greek physician Hippocrates, “All disease begins in the gut.” And since our founding in 1988, we at Health Products Distributors, Inc. (HPDI) have recognized the importance of supporting a healthy microbiome through diet, lifestyle, and the use of probiotic supplements.

We have written blog articles on developments regarding the microbiome, including “The Advantages of Soil Based Organisms for Health” (2014) and Dr. Hank’s short piece “A New View of the Role of Bacteria for Health” (2012).

However, the scientific understanding of the microbiome continues making quantum leaps. Every month it seems there is another groundbreaking study reported, or fresh information about the human microbiome highlighting specific aspects of its fundamental role in human health.

Gut health is paramount for good health.

Gut health is paramount for good health.

For example, studies showing the microbiome’s significance for brain function, digestive tract health, leaky gut, immune system function, and lifelong health. And even more, studies revealing potential connections between microbiome status and conditions involving the gut-brain axis, such as gluten sensitivity, celiac disease, ADHD, autism, depression, Parkinson’s disease, and Alzheimer’s disease.

As exciting as the studies are on a theoretical level, one of the main benefits is that many of them point to practical applications and suggestions that can be implemented on a daily basis by individuals wishing to improve microbiome health and vitality.

Information about means you can take to improve microbiome health is increasingly available not only in the scientific literature (which can be searched for in places like PubMed), but also in the popular media. For example, books like Dr. David Perlmutter’s Brain Maker: The Power of Gut Microbes to Heal and Protect Your Brain for Life (2015) include dietary recommendations and recipes. In addition, there are numerous books and online resources for making your own cultured foods (everything from kombucha tea to fermented condiments), as I will talk about more below.

sauerkraut kimchi yogurt probiotic fermented food microbiome

Fermented foods like sauerkraut, kimchi and yogurt provide beneficial bacteria.

Increasingly, individuals are speaking with their nutritionist or doctor on this topic, as knowledge of the important role of foods and nutrition in supporting a healthy microbiome.

While at the ACAM (American College for Advancement in Medicine) annual meeting in Las Vegas in November, I attended a presentation by Raphael Kellman, MD. He discussed the importance of the microbiome for supporting health, and the positive effects related to maintaining populations of beneficial flora, including the fact that probiotics can support positive emotions.

I present a few recommendations for supporting and improving microbiome health through lifestyle, dietary choices, and the use of probiotic supplements.


Dietary choices are among the simplest, yet most effective means for effecting improvement  in the human microbiome. Here are some dietary recommendations that are known to work.

Consume Foods High in Probiotics, including Fermented Foods. Foods high in probiotics include yogurt, kefir, sauerkraut, kim chee, tempeh, pickles and other pickled vegetables, and kombucha tea.

Probiotic foods provide you directly with good-for-you bacteria that help keep your microbiome diverse and well balanced.

Historically, many of the most important bacteria for gut health are lactobacteria and bifidobacteria. Some of the most well-recognized strains of these types include L. acidophilus, B. longum, B. bifidum, L. fermentum, and L. rhamnosus.

Notably, studies indicate reduced levels of lactobacteria and bifidobacteria in depressed individuals. While these two types of bacteria are perhaps the most studied and well-known, there are hundreds or thousands of different types of beneficial bacteria in the human microbiome. I will talk more about some of them when I discuss soil-based organisms.

Source probiotic foods that are organic, biodynamic, garden grown, and free-range / pasture-raised (e.g., dairy products). For pickles and relishes should preferably be unpasteurized and fermented in brine.

Consume Prebiotic Foods. It is important to consume foods that provide non-digestible short-chain fatty acids (SCFA) that support a flourishing good-for-you microbial community. Prebiotic foods include onions, garlic, asparagus, radishes, beans, oats.

Many prebiotic foods contain relatively high amounts of inulin, which is a soluble dietary fiber and a naturally occurring oligosaccharide. Inulin belongs to a class of carbohydrates called fructans.

Inulin selectively feeds beneficial bacteria. Major inulin-containing foods include Jersusalem artichoke (sunchokes), bananas, leeks, beets, and certain herbs. Chicory root, elecampane root, and dandelion root are especially high in inulin.

The fermentation of indigestible complex carbohydrates like inulin (and other natural dietary fibers) in the digestive tract results in the production of short-chain fatty acids that feed beneficial microbiota.

asparagus prebiotic microbiome beneficial bacteria

Asparagus contains the prebiotic inulin.

The three primary short chain fatty acids created by gut bacteria are acetic, butryic, and propionic acids. These fatty acids are excreted or absorbed by the colon and used for energy by cells. For example, butyric acid provides fuel for cells lining the colon and is associated with positive benefits.

Because different bacterial species produce different fatty acids, the ratio of the different species is important for health. In particular, butyric acid is associated with positive health benefits.

In contrast, clostridial species produce proprionic acid (PPA), which is too high quantities is known to exert adverse effects in the body, including the brain. Interestingly, studies show that autistic individuals harbor more clostridial species some of which are remarkably absent in normal populations.

At least one comparative study showed the the microbiomes of urban, Western populations (consuming more refined foods) produce relatively high levels of proprionic acid whereas the microbiomes found in rural, non-western populations (consuming more dietary fiber) produce more butyric acid.

Other studies indicate that the microbiome of rural populations predominantly contains bacteroides type flora (associated with lean body mass) and urban populations contain primarily firmicutes (associated with obesity when predominant).

Consume vegetables, including leafy green vegetables: Diets that include relatively high amounts of greens are beneficial for feeding a diverse and healthy microbial community. This is not only because of high-nutrient density and dietary fiber, but also due to the beneficial bacteria naturally present in these foods.

Reduce intake of sugars, especially refined sugars and high-fructose corn syrup. Natural sugars in fruits and vegetables are generally better to consume because they are ingested along with dietary fiber as part of the whole food. Refined sugars and especially high-fructose corn syrup (HFCS) test the body’s capacity for dealing with sugar, stress the body, prematurely age cells (via glycation processes), and promote adverse changes that can ultimately lead to diabetes.

Avoid foods containing antibiotics. Antibiotics in foods damage the microbiome by killing bacteria (including beneficial bacteria), reducing microbial diversity, and leaving the microbiome vulnerable to hostile takeover. Thus, consume only free-range, antiobiotic-free meats, eggs, and poultry. Avoid factory farmed meats and farmed fish.

Avoid simple carbohydrates. Like refined sugars, refined carbohydrates and grain products are notorious culprits for producing an imbalanced microbiome. So, avoid overconsuming processed grains, especially those containing wheat.

Avoid gluten. Wheat and the gluten it contains has been implicated in adverse conditions for the microbiome. Yet, wheat isn’t the only food containing gluten. While this may sound like advice given only for celiacs or IBS patients, the picture emerging regarding gluten is that it is associated with adverse changes in the microbiome. Similarly, adverse changes in the microbiome are associated with the development of gluten sensitivity and celiac disease.

one hundred percent organic

Organic and biodynamic foods support a healthy microbiome.

Avoid genetically modified foods (GMOs). The consensus is emerging that genetically modified (or genetically engineered) foods contribute to problems in the microbiome. Herbicides used on GMO crops, such as glyphosate, harm the microbiome and contribute to states of depleted nutrition.

Avoid artificial sweeteners. As bad as refined sugars are for the microbiome, artificial sweeteners can be just as bad or worse. Beyond the fact that artificial sweeteners tend to be toxic, they are known to produce adverse changes in the microbiome.

Choose organic, biodynamic, pesticide-free, and garden-raised. Regarding food choices, do your best to obtain naturally grown foods and to avoid agricultural chemicals.


Avoid Antibiotics. Whenever possible, avoid taking antibiotics. These can destroy the balance in your microbiome.

Avoid antimicrobial products. These include soaps (containing triclosan and other chemicals), antimicrobial coatings (like Microban), and antibacterial substances.

Avoid chemicals that affect your microbiome. For example, avoid products and foods with synthetic, toxic preservatives. Drink filtered water (i.e., non-chlorinated water).

Get Dirty. Try gardening, spend time outdoors, or just be in nature more often. Unpolluted soils are an excellent source of natural microbes needed to keep you microbiome in balance.


In addition to consuming probiotic and prebiotic foods, it can be helpful to take a probiotic supplement. Many of the probiotic supplements on the market provide a full complement of lactobacteria and/or bifidobacteria (often in the same formula).

It is especially useful to take probiotic supplements after exposure to antibiotics. However, probiotic supplements can offer be an effective adjunct to a probiotic (and prebiotic) friendly diet.

More recently, soil based organisms have garnered attention as important constituents of a healthy microbiome. These differ from lactobacteria, and in many ways are hardier and easier to get into the gut where they can thrive. It is also known that fulvic and humic acids act as prebiotics feeding microbes found in soils (soil based organisms) that support human health.


There are thousands of different types of bacteria found naturally in soils. These bacteria in soil and dirt historically performed many beneficial functions for us. It appears they help our bodies regulate immunity, and protect us from bacterial and fungal overgrowths in our intestinal tracts.

Up until 100 years ago (or less for some people), soil based organisms were an everyday part of the diet. Not that long ago, our country was comprised mostly of farmers. Agriculture was more about getting dirty than about efficient machinery and chemicals inputs (i.e., industrial agriculture). At that time, almost everyone would have consumed soil based organisms on vegetables and other foods from the fields, gardens, and orchards.

Today due to lack of exposure to soil based organisms resulting from modern food processing systems and the extensive use of pesticides that destroy the organisms, the average person has a very different composition of intestinal flora from their ancestors. There are far fewer soil based organisms, and more lactic acid bacteria. In addition, the use of antibiotics for young children has further swayed the balance away from these beneficial bacteria.

soil based organisms carrots

Healthy soils host soil based organisms. Foods grown traditionally without the use of synthetic herbicides and fertilizer provide high levels of SBOs naturally.

With a dramatic rise in research into the benefits of soil based organisms, new products have been developed that help us reintroduce them into our intestinal tracts. There they offer many benefits, including improving digestion, boosting immunity, and supporting overall good health in the intestines (with such benefits as reduced bloating, flatulence, and constipation).

And for example, certain soil based organisms are known to secrete proteins activating the immune system, as well as stimulating the production of white blood cells and antibodies.


Increasing evidence supports the idea that soil based organisms are essential for human health. Here are a few of the reported benefits:

  • Improved Gastrointestinal Health
  • Prevention of Gut Colonization by Harmful Bacteria and Fungi
  • Support for Intestinal Regeneration
  • Support for Balancing Gut Microbiota
  • Help Balance Colon pH
  • Increase Resistance to Harmful Bacteria and Fungi
  • Increase Absorption of Nutrients in the Intestines
  • Help Replenish Friendly Microflora in the Colon
  • Support Overall Health and Well Being
  • Enhance Metabolism in the Gut
  • Promote and Normalize Bowel Function
  • Help Reduce Gas and Bloating
  • Improve Immune System Function
  • Improve GI Tract Barrier Function
  • Many Other Benefits


Most people today either take or are aware of the benefits of probiotics containing lactic acid-based bacteria. These include commonly known strains of lactobacilli and bifidobacteria. Lactic-acid bacteria certainly are beneficial. There is a large body of research showing their high value for supporting digestion, immunity, and many other benefits. But they do have certain limitations.

Many of the lactic acid bacteria in probiotic formulas have difficulty making it through the stomach’s acidic environment. Thus, the bacteria arrive in the small intestine in vastly reduced numbers compared to the amount that must be consumed. Nutritionists therefore usually recommend taking probiotics with a large number of “colony forming units” (CFU) in order to ensure viability of the bacteria.

In addition, the benefits conferred by taking lactic acid bacteria may depend upon continuing usage. That is, certain studies indicate the benefits of these bacteria are greatly reduced after usage ends.

Soil based organisms offer several advantages compared to lactic-acid bacteria. First, they are extremely hardy and better able to withstand the acidic environment in the stomach. They are in fact, “endospore-forming” bacteria that surround themselves in a hard exterior that travels more effectively through the intestinal tract.

This means soil based organisms are far more likely to arrive intact in the small intestines (where they need to be) than lactobacteria. It also means that products containing soil-based organisms can provide fewer colony forming units and still be effective. That is, probiotic supplements with soil based organisms are more efficient at getting CFUs into the small intestines. It also eliminates or reduces the need for special coatings,  manufacturing processes, or “delivery systems” that must be created as a means to improve delivery rates of lactic acid bacteria.

Soil based organisms have also been shown to colonize the gut more effectively than lactic-acid bacteria. This may partially relate to the fact that they are hardier and make it to the small intestines in greater numbers. A major benefit is that this characteristic of SBOs may allow a reduction is dosage onto a “maintenance” level sooner without concerns that benefits of probiotic supplementation will disappear.


We at Health Products Distributors, Inc. researched various products containing soil based organisms. We choose to carry Prescript-Assist™, which is an effective and well-regarded broad spectrum probiotic and prebiotic formula.

Prescript-Assist™ provides 29 naturally resilient strains that support your body’s natural intestinal balance. Having so many strains means that this formula better reflects the great microbial diversity of the intestines versus typical probiotic products. In fact, more than 1,000 different species of microbes inhabit the human gut. Prescript-Assist™ includes Bacillus subtilis, which is a well-proven probiotic species found in traditional foods.

Below is a complete list of the strains of soil based organisms provided by Prescript-Assist. One 600 mg capsule of Prescript-Assist includes the following microorganisms (as well as the prebiotic Leonardite):

Arthrobacter agilis, Arthrobacter citreus, Arthrobacter globiformis, Arthrobacter luteus, Arthrobacter simplex, Acinetobacter calcoaceticus, Azotobacter chroococcum, Azotobacter paspali, Azospirillum brasiliense, Azospirillum lipoferum, Bacillus brevis, Bacillus marcerans, Bacillus pumilus, Bacillus polymyxa, Bacillus subtilis, Bacteroides lipolyticum, Bacteriodes succinogenes, Brevibacterium lipolyticum, Brevibacterium stationis, Kurthia zopfii, Myrothecium verrucaria, Pseudomonas calcis, Pseudomonas dentrificans, Pseudomonas fluorescens, Pseudomonas glathei, Phanerochaete chrysosporium, Streptomyces fradiae, Streptomyces cellulosae, Streptomyces griseoflavus.

The number and types of species found in the gastrointestinal (GI) tract can be a major difference between a well functioning digestive system and immune system, and those less than optimally functional. In scientific studies, individuals exhibiting higher levels of gastrointestinal distress and gut irregularities have been found to have a correspondingly lower variety of beneficial bacteria in the intestines.

Benefits of Probiotics soil based organisms

Benefits of probiotics, including SBO formulas like Prescript-Assist


Prescript-Assist™ is a clinically proven probiotic supplement designed to ensure maximum viability of the many organisms it provides. The formula offers inherent viability because the species it provides are naturally adapted for survival in the human gastrointestinal tract. That is, these 29 species are environmentally based (SBO) species drawn from the terrestrial microbiome where they have prospered and adapted for millenia to beneficially coexist with humans.

Unlike conventional Lactobacillus and Bifidobacterium probiotics, the strains in Prescript-Assist are a balanced formulation of a new generation of probiotics, capable of forming a protective shield until reaching the probiotic-friendly environment of the intestines. These organisms are resistant to acid, bile, and heat. In fact, routine testing of Prescript-Assist confirms it has a 95% viability two years after date of manufacture.

The inherent viability of the soil based organisms in Prescript-Assist means there are no requirements for nano-encapsulation or hard-shelled enteric-coated capsules, which both are essentially attempts to force viability of probiotic species rather than utilizing hardy strains naturally preadapted to our bodies.

Typical probiotic formulas therefore contain the relatively low-viability lactic acid bacteria that must be protected by technologies (e.g., microencapsulation) due to their inherent fragility. These fragile bacteria have a difficult time surviving because they are readily destroyed within the acidic environment of the stomach. Although patented enteric coatings can help survival rates, the provision of high-viabiltiy organisms that reach the intestines intact due to the inherent strength of their natural spore structure makes more sense as a means to protect against degradation in the stomach and intestinal tract.

Prescript-Assist™ provides bacteria that reach the intestines intact due to the fact that the spore structure protects against degradation or destruction by stomach acids.

probiotics-pros-cons soil based organisms

Benefits of soil based organisms in Prescript-Assist versus lactic acid bacteria formulas


Science has shown that a baby’s exposure to maternal bacterial cultures during natural birth help it to form a healthy, disease-resistant bacterial defense. Likewise, the environmental and soil-based bacteria commonly found in foods grown in fertile organic soils assist in growing and maintaining a healthy makeup of internal flora in humans.

This is the basis of SBO (soil based organism) probiotics like Prescript-Assist.™ SBO probiotics have risen in recognition recently as clinical evidence grows to support their effectiveness. Species from the Bacillus genus, a gut-adapted spore-forming bacteria found in Prescript-Assist, have been demonstrated safe and effective in in vitro and in vivo studies (see Resources section below).

Dr. Mehmet Oz of the Dr. Oz Show says, “Spore form probiotics are the Chuck Norris of probiotics: total tough guys. They have to be to survive splashing around in your stomach’s acid bath. Wimpier types—including live cultures in yogurt—often throw in the towel.”

Among brands of SBO probiotics, Prescript-Assist offers the greatest diversity of species. It is the diversity and the resilience of the Prescript-Assist formulation that accounts for its proven success in peer-reviewed, published clinical trials.


The Human Microbiome Project (NIH-funded five-years research study by a consortium of nearly 80 universities and institutions) confirmed that the number of microbial species found in the human intestines numbers in the thousands rather than hundreds.

Just as importantly, the project results showed that the distribution of a variety of strains capable of performing similar tasks is more important than the individual species themselves. This information underscores the importance of broad spectrum diversity, and therefore the role that can be played by multi-strain probiotic complexes, such as Prescript-Assist.

microbes over time soil based organisms

Soil based organisms in the human microbiome change during the life cycle.

A review article in Cell refers to the gut as a “natural laboratory for studying the ‘microevolution’ of humans.” The authors write: “In this view, we are seen as superorganisms composed of an amalgam of both microbial and H. sapiens cells, where the survival of microbe and human is interdependent.”

With its balanced formulation of 29 beneficial strains selected to mimic the natural flora found in traditional and paleolithic diets, Prescript-Assist is the only professional-grade probiotic to contain 29 species, 12 different genera, and all four of the most common phyla found in the human digestive tract, including Firmicutes, Bacteroidetes, Actinobacteria, and Proteobacteria.

soil based organisms human skin

Prevalence on skin sites of different types of bacteria, including soil based organisms.



Prescript-Assist offers exceptional shelf stability. It is well known that conventional probiotics (i.e., lactic acid bacteria) are readily damaged, degraded, and destroyed by heat and pressure during the manufacturing process. They are also degraded by exposure to light and by temperature changes. Because they lack shelf stability, if they are not kept refrigerated, they often cannot provide a sufficient quantity of organisms by the time of ingestion.

In contrast, Prescript-Assist features probiotic bacteria protected by a durable seed-like structure, so that they are better safeguarded against environmental factors, including heat, pressure, light, or temperature variability. Indeed, testing confirms that the probiotic bacteria in Prescript-Assist remain 95% viable two years after their date of manufacture without any need for refrigeration.


Most probiotic formulas do not contain any prebiotics, which are a food source for bacteria, and help accelerate their growth. Prescript-Assist uniquely contains Leonardite, which is a prebiotic mixture of humic and fulvic acids, which allows the beneficial bacteria to proliferate and thrive.

Fulvic and humic acids belong to a group of organic substances called humic substances. These are dark brown constituents of humus found in soil that contribute to the character of soil, and are precursors to fossil fuels. They are also found in peat, coal upland streams, dystrophic lakes, and ocean water. Both humic acid and fulvic acid are excellent chelators and powerful antioxidants.

Humic acid is normally found in the form of “humate” (the salt of humic acid), i.e., humic acid bound to a nutritional mineral element. Fulvic acid is normally found in the form of ‘fulvate’ (the salt of fulvic acid), i.e., fulvic acid bound to a nutritional mineral element.

A substantial fraction of the mass of the humic acids is in carboxylic acid functional groups, which endow these molecules with the ability to chelate (bind) positively charged multivalent ions (Mg2+, Ca2+, Fe2+, Fe3+, most other “trace elements” of value to plants, as well as other ions that have no positive biological role, such as Cd2+ and Pb2+).

This chelation of ions is probably the most important role of humic acids with respect to living systems. By chelating the ions, they facilitate the uptake of these ions by several mechanisms, one of which is preventing their precipitation, another appears to be a direct and positive influence on their bioavailability.

Humic acid and fulvic acid have been the subject of many years of scientific study not only because of their role in soil and plant biology, but also with respect to their chelation capabilities. That is, for their proven capacities in removing heavy metals from the human body.

Humic and fulvic acids bind only with double valency positive cations, i.e., nutritional elements and/or heavy metal ions. It is likely that a heavy metal ion will displace a lighter, nutritional metal ion and bind with the humate or fulvate.

Many health care practitioners recommend fulvic acid as an electrolyte (to increase cellular electrical efficiency) and supplement to take in combination with trace mineral supplements in order to assist in their uptake by the body. Fulvic acid bonds with these minerals. Because it is a small molecule and therefore easily able to pass through cell membranes, it allows delivery of the minerals efficiently into cells.

Most products are based on processed humate, taken from high quality soil sources, containing large amounts of nutritional cations already bound into the matrix. They are therefore not likely to deplete an individual’s mineral levels. As fulvic acid/fulvate is the smaller molecule, it is more easily absorbed into the cells. It is regarded as an excellent method of delivery for trace elements and nutrients into the body, as well as being an excellent chelator.

Observed Effects of Humic Acids on Animals

Our focus in this article is upon the effects of soil based organisms and prebiotics (e.g., humic and fulvic acids) in humans. However, it is worth noting that various animal studies show a large number of benefits. These studies show the following benefits:

Covering mucous membrane and adstringent effects

Humic acids can form a protective film on the mucuous epithelium of the gastrointestinal tract against infections and toxins. The macrocolloidal structure of humic acids ensures a good shielding on the mucous membrane of the stomach and gut, the peripheral capillaries, and damaged mucosal cells. As a result of this process, the resorption of toxic metabolites is reduced or fully prevented, especially after infections, in case of residues of harmful substances in foods. Furthermore, humic acids help to prevent excessive loss of water via the intestine.

Antibacterial and virucidal effects

Humic acids can influence the metabolism of proteins and carbonhydrates of microbes by catalytic means. This leads to a directly damaging effect against bacteria or viruses. A second mechanism is related to the interionic bonds of high-molecular protein fractions (toxins) of infectious microbes. Their toxic impact on physiological processes of mucous membrane cells can be weakened considerably or even completely blocked.

Antiphlogical effects

Dermal, oral, or subcutaneous application of humic acids leads to inhibitory effects on inflammation. The ability to inhibit inflammation is considered to be related with the flavonoid groups contained in humic acids.

Antiresorptive and adsorptive effects

As high-molecular humic acids remain in the gastrointestinal tract almost entirely following the enteral application (there is no self-resorption), antiresorptive and adsorptive effects take place where they are needed—in the digestive tract. Primarily cationoid noxes (protein toxins, toxic substances) are fixed, their resorption is reduced considerably or even prevented completely and their elimination through the bowel is promoted. As adsorption by humic acids includes not only physical and chemical reactions, but also complex-formation and ion-exchange, it is more intensive and dynamic compared to purely physical adsorbents.

Effects on the immune system

Humic acids stimulate the resistance forces of the body and lead to an increase in the phagocytosis activity. The inducer effect of phenolic components (groups) of humic acids is believed to be responsible for the immunological effects and is the basis for the success of the treatment of the so-called “factor” diseases in young animals.

Ergotropic effects

Humic acids stabilize the intestinal flora, thereby ensuring improved utilization of nutrients in foods. This leads to an increase in liveweight of the animal without increasing the amount of feed given to the animal.


prescript-assist-probiotic-fsmall soil based organisms

Prescript-Assist provides 29 strains of beneficial soil based organisms.


Probiotic supplement formulas typically do not offer product-specific clinical studies validating their effectiveness. Prescript-Assist™ is different. It is supported by a peer-reviewed, placebo-controlled human clinical trial, and a one-year follow-up study that verifies its long-term efficacy.

Below is a summary of major features and benefits provided by Prescript-Assist™.


  • No Need for Refrigeration.
  • Backed by Sound Science: Supported by peer-reviewed, published clinical studies.
  • Inherent Organism Viability: A matrix of superior, highly resilient microflora whose organic, seed-like structures survive the early GI tract to thrive in the intestines.
  • Contains Bacillus subtilis:  A proven probiotic species found in traditional foods.
  • 29 Symbiotic Organisms: A balanced formulation specially selected to mimic the natural flora found in traditional and paleolithic diets.
  • Proven Shelf Stable:  With variations of less than 5% over two years from date of manufacture when stored at 98°F / 37°C
  • Supported By Prebiotics. Includes Leonardite, a prebiotic mixture of humic and fulvic acids, which allows beneficial bacteria to proliferate and thrive.
  • Gluten-Free, Dairy Free, and Vegan.


As a dietary supplement for adults, take 1–2 capsules per day, or as directed by your health care professional. May be taken with or without food.


No refrigeration necessary. Store under normal conditions.

Shelf Life:

Routine viability testing confirms greater than 95% viability two years after date of manufacture — without refrigeration. See individual package for expiration dates.


We at HPDI always strive to bring our customers the best products and formulas available whether or not we ourselves design and produce them.

When the opportunity to carry Prescript-Assist™ arose, we were quick to recognize its many benefits and advantages. We offer this unique formula knowing that it is safe, effective, and can help improve the health of our customers and their patients.

We also know that Prescript-Assist can be used effectively in combination with our other supplements (i.e., HPDI foundational supplements and superfoods), including formulas we design specifically for GI health like Intestinal Rejuvenation Formula.

We take Prescript-Assist™ and experience major health benefits. In addition, we personally witness and hear from many individuals (including health care professionals) who have experienced the benefits of the formula. The results reported are excellent.

It is more important than ever to utilize our current (and rapidly expanding) knowledge about the human microbiome and its constituents to support optimal health and wellness. Science tells us that the human microbiome historically has been populated by a broad range of soil based organisms.

Where we have moved away from nature and traditional agriculture, individuals’ microbiomes can become less vibrant, diverse, and robust. Supplements like Prescript-Assist providing soil based organisms can help bring us closer to having a microbiome more closely resembling our healthy ancestors.



The Advantages of Soil Based Organisms for Health (from the HPDI blog)

A New View of the Role of Bacteria in Health (from the HPDI blog)

Prescript-Assist™ Broad Spectrum Probiotic & Prebiotic (from the HPDI blog)

Spore Form Probiotics Keep Your Digestive Tract Happy

Body’s Hardworking Microbes Get Some Overdue Respect (Science)

NIH Human Microbiome Project Defines Normal Bacterial Makeup of the Body (NIH)

Ecological and Evolutionary Forces Shaping Microbial Diversity in the Human Intestine (Cell)

Brain Maker: The Power of Gut Microbes to Heal and Protect Your Brain –for LifeDavid Perlmutter, MD.


The Safety of Bacillus subtilis and Bacillus indicus as Food Probiotics (J. Applied Microbiology)

The Safety of Two Bacillus Probiotic Strains for Human Use (Digestive Diseases and Sciences)


Prescript-Assist™ Probiotic Formula (HPDI website)

Intestinal Rejuvenation Formula (HPDI website)



Contact Us:

You can reach HPDI by calling 1-800-228-4265, email support(at)IntegratedHealth.com, or visit the retail website: www.IntegratedHealth.com

Health care professionals and retailers can apply for wholesale account, which includes access to the HPDI reseller website: www.HealthProductsDistributors.com