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IMMUNE ASSIST 24/7 ORGANIC MEDICINAL MUSHROOM EXTRACT TABLETS – NEW PRODUCT!

Dr. Hank Liers, PhD immune assist 24/7 medicinal mushroom extracts

These days there’s a lot of attention being focused on natural ways to boost immunity. Today I want to introduce you to a new immune system support supplement called Immune Assist 24/7™.

You may already be familiar with Immune-Assist Daily Formula, a product providing significant amounts of organic polysaccharide mushroom extracts I designed a few years ago. The mushrooms included in my original Immune-Assist Daily Formula are Agaricus blazei, Cordyceps sinensis and Cordyceps miltitaris, Lentinula edodes (shiitake), Grifola frondosa (maitake), Ganoderma lucidum (Reishi), and Coriolus versicolor.

INTRODUCING IMMUNE ASSIST™ 24/7

Immune Assist 24/7™ contains the same ingredients as Immune-Assist Daily Formula, but with a few significant additions. The formula includes more than 200 polysaccharides including beta-glucans and hetero-polysaccharides which combine both alpha- and beta-bound monosaccharides into the same molecule. This is a major reason that it shows a massive range of immuno-modulation bioactivity. Included among the important substances are Arabinoxylane, Lentinan, Grifolan (Dr. Nanba’s original Maitake D-Fraction), PSK and PSP, and Active Hemicellulose Correlated Compound (AHCC).

immune assist 24/7 organic medicinal mushroom extract tablets

Medicinal mushroom research has focused on discovering compounds that modulate, positively or negatively, the biological response of immune cells. Many mushroom-derived polysaccharides appear to fit the criteria for biological response modifier (BRM) compounds. They cause no harm and place no additional stress on the body, they assist the body in adapting to various environmental and psychological stresses, and they support the major systems, including nervous, hormonal, and immune systems, as well as regulatory functions.

In addition to the ingredients found in Immune-Assist Daily Formula, Immune Assist 24/7 contains the whole powder from organic Cordyceps sinensis and Cordyceps militaris that includes the mycelium, primordia, fruiting bodies, spores, and extracellular compounds. And here’s the bonus: each tablet contains 80 mg of the powerful antioxidant and Nrf2 activator epigallocatechin gallate (EGCG) extracted from organic green tea leaf. This is a really smart upgrade!

BENEFITS OF ORGANIC MEDICINAL MUSHROOMS IN IMMUNE ASSIST 24/7

The benefits of Immune Assist 24/7 include powerful support for enhanced energy production, anti-aging, improved athletic performance, heart function, lung function, and blood formation. Human, animal, and in vitro studies confirm that the ingredients in this formula consistently and effectively boost immune system function in the following ways:

• Stimulates cytokine (IL-2, IL-12, TNF, and Interferon) production, which stimulates immune function
• Increases Natural Killer (NK) cell activity
• Increases the formation of explosive granules within NK cells
• Increases the number and the activity of lymphocytes, specifically increasing T Cells
• Increases Interferon levels and stimulates NK Cell activity
• Increases the formation of TNF, a group of proteins that help destroy out-of-balance cells
• It is rich in adenosine and amino acids necessary for the production of ATP.
• Cordyceps has been shown to maintain healthy inflammation levelsimmune assist 24/7 organic medicinal mushroom extract tablets

IMMUNE ASSIST 24/7 INGREDIENTS

One tablet of Immune Assist 24/7 contains 960 mg of a proprietary organic blend of mushrooms, described above, and grown on organic white milo (growing substrate); organic green tea leaf extract; and an organic vegetarian base of FibregumBio™ (organic gum acacia) and organic carnauba wax. There are 45 servings per container of 90 tablets.

If you’d like to learn more about the amazing health benefits of medicinal mushrooms, I highly recommend Healing Mushrooms by Dr. Georges Halpern, MD, PhD. You can read the entire book for free (https://www.academia.edu/20332538/Healing_Mushrooms_by_Georges_Halpern).

Health Products Distributors has been selling Immune-Assist Daily Formula for more than 10 years, and it remains one of our top-selling supplements. During this health crisis we have totally sold out of this product and are waiting for new inventory. Because regular Immune-Assist Daily Formula is out of stock, I recommend Immune Assist 24/7 in order to support our customers.

I am pleased to acknowledge Immune Assist 24/7 is a very powerful immune-boosting and health enhancing supplement. If there is an immune system support supplement as potent as Immune-Assist Daily Formula, it might just be this one!

– Hank Liers, PhD

MEDICINAL MUSHROOM RESOURCES

Immune Assist 24/7 (tablets)

Immune-Assist Daily Formula (capsules)

Immune Strengthening Using Medicinal Mushrooms by Hank Liers, PhD

Immune-Assist Research Summary

Healing Mushrooms by Georges Halpern, MD, PhD

immune assist 24/7 organic medicinal mushroom extract tablets

 

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ULTIMATE PROTECTOR+ INGREDIENTS – MANGOSTEEN

Dr. Hank Liers, PhD biography about us HPDI integratedhealth formulator founder CEO scientist physicist wild bilberry and wild blueberry Ultimate Protector+ includes mangosteen extract, as well as extracts from 12 different fruits, vegetables, and herbs. Each of these ingredients contain substances that may be considered to be polyphenols, antioxidants, and Nrf2 activators. In this article, I explore the ingredient mangosteen (Garcinia mangostana) extract which is a component of SFB® – Standardized Fruit Blend from Ethical Naturals, Inc.

Ultimate Protector+ Includes Mangosteen

Ultimate Protector+ Includes Mangosteen

SFB® is a proprietary formula that combines extracts from Grape, Cranberry, Pomegranate, Blueberry, Apple, Mangosteen, Bilberry, Chokeberry, and Goji Berry. It is high in fruit polyphenols, flavonoids, anthocyanins, catechins, proanthocyanins, ellagic acid, xanthines, chlorogenic acid, pterostilbenes, resveratrol, phloridzin, zeaxanthin, and quinic acid. With its diverse blend, SFB® offers over 40–50% polyphenols as well as >9,000 ORAC units in a single gram.

Polyphenols, anthocyanins and other plant elements are powerful ingredients associated with a variety of areas of human health, including healthy aging, healthy glucose metabolism, cardiovascular health, and inflammation management.

HEALTH BENEFITS OF MANGOSTEEN

The Mangosteen extract in Ultimate Protector+ has been extracted with non-GMO food grade ethanol and distilled water. Testing has indicated the product contains over 10% polyphenols.

Mangosteen extract in obtained from the skin and whole fruit for which numerous biological activities have been reported including: antimutagenic, antibacterial, hypocholesterolemic, antioxidant, and protective against tumorigenesis.

Mangosteen contains nutrients with antioxidant capacity, such as vitamin C and folate. Plus, it provides xanthones — a unique type of plant compound known to have strong antioxidant properties. In several test-tube and animal studies, the antioxidant activity of xanthones has resulted in anti-inflammatory, anticancer, anti-aging, heart protective, and antidiabetic effects.

Additionally, some research suggests that certain plant compounds in mangosteen may have antibacterial properties — which could benefit your immune health by combating potentially harmful bacteria. In a 30-day study in 59 people, those taking a mangosteen-containing supplement experienced reduced markers of inflammation and significantly greater increases in healthy immune cell numbers compared to those taking a placebo.

Metabolite Composition of Mangosteen

Xanthone is one of the compound classes that are prevalent in mangosteen. These metabolites have been extracted and characterized in various studies as reviewed by several publications. So far, there are more than 68 xanthones isolated from the mangosteen fruit with the majority of them are a- and c-mangostin. The molecular structure of these compounds have been elucidated and more recently, novel xanthones have been discovered such as 1,3,6-trihydroxy-2-(3-methylbut-2-enyl)-8-(3-formyloxy-3-methylbutyl)–xanthone, 7-O-demethyl mangostin, garmoxanthone, as well as mangostanaxanthone III, IV, and VII. These xanthones were also implicated in various pharmaceutical properties but more studies are needed to verify their effectiveness in human applications.It is interesting that using subcritical water extraction to extract xanthones from mangosteen fruit, eliminated the need for the chemical solvents.

A study showed that the aqueous micellar biphasic system they developed could also efficiently extract xanthones from mangosteen pericarp. This suggests that xanthones could be viable for human application but bioavailability studies need to be performed in the future to ascertain their delivery and efficacy. Interestingly, solubilizing a-mangostin in soybean oil (containing traces of linoleate, linolenic acid, palmitate, oleic acid, and stearate) improved the xanthone bioavailability in rats, such that the compound was found in brain, pancreas, and liver organs after 1 h treatment. This signifies the potential of using oil-based formulation for increasing the bioavailability of xanthones.

Other than xanthones, mangosteen pericarp is also known to contain one of the highest procyanidin content, compared to other fruit such as cranberry, Fuji apple, jujube, and litchi. These procyanidins including monomer (47.7%), dimer (24.1%), and trimer (26%) may also contribute to the antioxidant capability of mangosteen extract as shown in 1,1-diphenyl-2-picrylhydrazyl (DPPH) and Ferric Reducing Antioxidant Power (FRAP) assays. Other phenolics such as benzoic acid derivatives (vanilic acid and protocatechuic acid), flavonoids (rutin, quercetin, cactechin, epicatechin) and anthocyanins (cyanidin 3-sophoroside) were also highly present in mangosteen pericarp.

Furthermore, mangosteen compounds have also been profiled using metabolomics approach. Using GC-MS analysis, a study reported that mangosteen pericarp contains mainly sugars (nearly 50% of total metabolites) followed by traces of other metabolite classes such as sugar acids, alcohols, organic acids, and aromatic compounds. This study also found several phenolics such as benzoic acid, tyrosol, and protocatechuic acid which are known to possess anti-oxidative and anti-inflammatory activities.

SCIENTIFIC STUDIES ON THE ANTIOXIDANT EFFECTS OF MANGOSTEEN

Below, I provide relevant scientific studies on the antioxidant effects and potential health benefits of mangosteen.

Recent updates on metabolite composition and medicinal benefits of mangosteen plant

Wan Mohd Aizat, Ili Nadhirah Jamil, Faridda Hannim Ahmad-Hashim and Normah Mohd Noor
Institute of Systems Biology (INBIOSIS), Universiti Kebangsaan Malaysia (UKM), Bangi, Selangor, Malaysia

From: https://peerj.com/articles/6324.pdf

ABSTRACT

Background: Mangosteen (Garcinia mangostana L.) fruit has a unique sweet-sour taste and is rich in beneficial compounds such as xanthones. Mangosteen originally been used in various folk medicines to treat diarrhea, wounds, and fever. More recently, it had been used as a major component in health supplement products for weight loss and for promoting general health. This is perhaps due to its known medicinal benefits, including as anti-oxidant and anti-inflammation. Interestingly, publications related to mangosteen have surged in recent years, suggesting its popularity and usefulness in research laboratories. However, there are still no updated reviews (up to 2018) in this booming research area, particularly on its metabolite composition and medicinal benefits.

Method: In this review, we have covered recent articles within the years of 2016 to 2018 which focus on several aspects including the latest findings on the compound composition of mangosteen fruit as well as its medicinal usages.
Result: Mangosteen has been vastly used in medicinal areas including in anti-cancer, anti-microbial, and anti-diabetes treatments. Furthermore, we have also described the benefits of mangosteen extract in protecting various human organs such as liver, skin, joint, eye, neuron, bowel, and cardiovascular tissues against disorders and diseases.

Conclusion: All in all, this review describes the numerous manipulations of mangosteen extracted compounds in medicinal areas and highlights the current trend of its research. This will be important for future directed research and may allow researchers to tackle the next big challenge in mangosteen study: drug development and human applications.

α-Mangostin induces apoptosis in human chondrosarcoma cells through downregulation of ERK/JNK and Akt signaling pathway.

2011 May 25;59(10):5746-54. doi: 10.1021/jf200620n. Epub 2011 Apr 11.
Krajarng A1, Nakamura Y, Suksamrarn S, Watanapokasin R.
From: https://www.ncbi.nlm.nih.gov/pubmed/21446759

Abstract

Chondrosarcoma is a malignant primary bone tumor that is resistant to chemotherapy and radiation therapy. α-Mangostin, a component of Garcinia mangostana Linn, is a xanthone derivative shown to have antioxidant and antitumor properties. This study is the first to investigate anticancer effects of α-mangostin in the human chondrosarcoma cell line SW1353. We showed that α-mangostin inhibited cell proliferation of SW1353 cells in a time- and dose-dependent manner by using the trypan blue exclusion method. Hoechst 33342 nuclear staining and nucleosomal DNA-gel electrophoresis revealed that α-mangostin could induce nuclear condensation and fragmentation, typically seen in apoptosis. Flow cytometry using Annexin V/PI double staining assessed apoptosis, necrosis and viability. α-Mangostin activated caspase-3, -8, -9 expression, decreased Bcl-2 and increased Bax. This promotes mitochondrial dysfunction, leading to the release of cytochrome c from the mitochondria to the cytoplasm. In addition, total and phosphorylated ERK and JNK were downregulated in α-mangostin-treated SW1353 cells but no changes in p38. α-Mangostin also decreased phosphorylated Akt without altering total Akt. These results suggest that α-mangostin inhinbited cell proliferation and induced apoptosis through downregulation of ERK, JNK and Akt signaling pathway in human chondrosarcoma SW1353 cells.

Characterized mechanism of alpha-mangostin-induced cell death: caspase-independent apoptosis with release of endonuclease-G from mitochondria and increased miR-143 expression in human colorectal cancer DLD-1 cells.

2007 Aug 15;15(16):5620-8. Epub 2007 May 18.
Nakagawa Y, Iinuma M, Naoe T, Nozawa Y, Akao Y.

From: https://www.ncbi.nlm.nih.gov/pubmed/17553685

Abstract

alpha-Mangostin, a xanthone from the pericarps of mangosteen (Garcinia mangostana Linn.), was evaluated for in vitro cytotoxicity against human colon cancer DLD-1 cells. The number of viable cells was consistently decreased by the treatment with alpha-mangostin at more than 20 microM. The cytotoxic effect of 20 microM alpha-mangostin was found to be mainly due to apoptosis, as indicated by morphological findings. Western blotting, the results of an apoptosis inhibition assay using caspase inhibitors, and the examination of caspase activity did not demonstrate the activation of any of the caspases tested. However, endonuclease-G released from mitochondria with the decreased mitochondrial membrane potential was shown. The levels of phospho-Erk1/2 were increased in the early phase until 1h after the start of treatment and thereafter decreased, and increased again in the late phase. On the other hand, the level of phospho-Akt was sharply reduced with the process of apoptosis after 6h of treatment. Interestingly, the level of microRNA-143, which negatively regulates Erk5 at translation, gradually increased until 24h following the start of treatment. We also examined the synergistic growth suppression in DLD-1 cells by the combined treatment of the cells with alpha-mangostin and 5-FU which is one of the most effective chemotherapeutic agents for colorectal adenocarcinoma. The co-treatment with alpha-mangostin and 5-FU, both at 2.5 microM, augmented growth inhibition compared with the treatment with 5 microM of alpha-mangostin or 5 microM 5-FU alone. These findings indicate unique mechanisms of alpha-mangostin-induced apoptosis and its action as an effective chemosensitizer.

 

γ-Mangostin, a xanthone from mangosteen, attenuates oxidative injury in liver via NRF2 and SIRT1 induction

Abstract

γ-Mangostin (γ-man), an active compound from Garcinia mangostana L., has been discovered as a hepatoprotective agent against oxidative injury. However, the underlying mechanisms remained unclear. The current study showed that γ-man stimulated the nuclear translocation of nuclear factor erythroid 2-related factor 2 (NRF2) to enhance antioxidant capacity under oxidative stress, which was partially reversed by treatment of the NRF2 inhibitor, all-trans-retinoic acid. Moreover, γ-man increased the expression and activity of SIRT1 (silent mating type information regulation 2 homolog 1), which facilitated the deacetylation of peroxisome proliferator-activated receptor γ coactivator 1α to improve the mitochondrial function in L02 cells. The protective effect of γ-man was partially blocked by treatment of the SIRT1 inhibitor tenovin-1 or SIRT1 knockdown. In vivo studies showed γ-man protected mice from carbon tetrachloride-induced acute liver injury, through up-regulation of NRF2 and SIRT1. Thus, γ-man might be a candidate to protect liver from acute oxidative injury.

SUMMARY

Mangosteen is an important fruit full of polyphenols, anthocyanins, antioxidants, xanthones, and Nrf2 activators that help to make Ultimate Protector+ such an outstanding nutritional supplement.

Mangosteen
MANGOSTEEN, Garcinia mangostana—Painted by Dr. M.J. Dijkman

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EXCITING NEW TERRAFLORA SYNBIOTIC

Terraflora Synbiotic

Dr. Hank Liers, PhD Terraflora synbioticIt has finally arrived — the exciting new Terraflora™ synbiotic. A synbiotic is a combination of probiotics and supporting prebiotics. This advanced soil-based organisms formula fills the need for a superb probiotic/prebiotic in Health Products Distributors’ arsenal of highly effective formulas. Terraflora is extremely supportive of your entire microbiome and gut-based immune system.

 

ADVANCED GUT MICROBIOME SUPPORT

INTRODUCING THE MICROBIOME

For centuries, scientists have recognized a limited number of pathogenic bacteria for which antibiotic therapies have become the mainstream treatment. However, advanced DNA sequencing techniques coupled with data revealed from the Human Genome Project have made it possible to study a vast world of ‘germs’ – both pathogenic and beneficial – that dwarf our previous knowledge.

While we inherit more than 22,000 genes from our parents, the bacteria that exist in and on our bodies contain at least eight million bacterial genes which amounts to 360 times more bacterial genes than human genes! The genetic material from bacteria that populate the human body is known as the human microbiome.

Your microbiome is likely similar to that of your immediate family, as we naturally inherit our family’s microbiota. Through the course of our lives, we pick up other bacteria from food, water, and various components of our environment. Scientists estimate that we each carry 100 trillion bacteria in our intestinal tract alone!

In this teeming landscape of bacteria, both you and the bacterial communities derive benefit. Many researchers use the term “mutually beneficial” when describing the evolving bacterial communities in our gut.

THE BALANCE OF BACTERIA AND YOUR HEALTH

In 2010, the Human Microbiome Project published an analysis of 178 genomes from bacteria that live in or on the human body. 10,000 different types of bacteria in the human body have been identified, including novel genes and proteins that serve functions in human health and disease. The vast numbers of bacteria discovered appear to provide benefit to the human body, not harm.

Martin J. Blaser, chairman of the Department of Medicine and a professor of microbiology at the New York University School of Medicine states: Germs make us sick, but everyone focuses on the harm. It’s not that simple, because without most of these organisms we could never survive.

As scientists map the human microbiome, they are beginning to understand the difference between normal and abnormal. Proper bacterial balance is vital to healthy immune function, providing appropriate protection against potential infections, playing a critical role in the digestion and absorption of food and nutrients, and even regulating mood. The interaction of multiple strains of bacteria is an essential element in health and wellbeing.

The optimal balance of bacteria can be altered in many ways such as broad spectrum antibiotics that kill bacteria in the gut indiscriminately; prescription medications; disease-carrying bacteria, fungi, parasites, and yeasts; stress; lack of sleep; poor diet & lifestyle; geography and travel; and physical disconnection with nature.

Researchers have shown that changes in gut bacteria even affect the brain and personality. For example, germ-free mice have been shown to be dramatically more anxious and hyperactive than their counterparts with a normal microbiome. These changes have also been associated with neurochemical changes in the mouse brain.

Evidence supports the concept that microbiota balance can have a large impact on healthy metabolic processes. This delicate balance has a definite impact on nutrient acquisition and overall energy regulation.

The impact of the gut microbiota is far reaching in the body. Continued investigation into the microbiome will yield powerful data, enabling the development of novel options to support healthy mood, metabolism, signaling molecules and much more.

Terraflora

FEATURES OF TERRAFLORA

Terraflora is a novel broad spectrum synbiotic formulated with a combination of spore form probiotics, and advanced, food-based, ancient prebiotics designed for robust support of gastrointestinal health.

  • Innovative gut microbiome support
  • Multi-strain, soil-based, beneficial bacteria to support microbial diversity in the GI tract
  • Proprietary blend of ancient, wild-harvested, certified organic prebiotic support
  • Terraflora’s advanced formulation of beneficial strains and ancient prebiotics are designed to support the biodiversity reflected in ancestral diets
  • Shelf stable and requires no refrigeration
  • Highly bioavailable strains are protected by a natural seed-like structure, guarding against environmental factors and stomach acid
  • Strains effectively generate highly bioavailable riboflavin (vitamin B2) and antioxidant carotenoids, right at the sight of absorption
  • Induces anti-inflammatory effects to foster gut homeostasis
  • Supports immune health

TERRAFLORA KEY BENEFITS

VIABILITY – The natural seed-like structure encasing the probiotc bacteria in Terraflora protects them against degradation by stomach acid, so they reach their target destination — the lower GI tract — intact and alive.

ADVANCED PREBIOTIC SUPPORT – Uniquely formulated with organic seaweeds (see reference 2 below), mushroom extracts (see reference 1 below), and humic acid (see reference 3 below). Terraflora’s advanced prebiotic complex contains a diverse spectrum of naturally occurring food-based polyphenols and polysaccharides designed to support healthy intestinal flora

ANTIOXIDANT BENEFITS – Terraflora features Ribospore™ (Bacillus pumilus) and Bacillus megaterium EM144™, two novel probiotic strains shown in studies to produce highly bioavailable, gastric stable antioxidant carotenoids, right at the site of absorption.

CONVENIENT — NO REFRIGERATION REQUIRED! – To ensure potency and viability, most probiotics require refrigeration and have a short shelf life. The inherently resilient bacteria in Terraflora are heat-stable, and require no refrigeration, uniting convenience and efficacy.

WHY SOIL-BASED ORGANISMS?

Through diet and lifestyle, our earliest ancestors were routinely exposed to spore-based bacteria found in healthy soils and our natural environment. In our modern and hyper-sanitized world, this primitive yet vital connection to nature has been all but lost.

Soil-based organisms (SBOs) define a class of probiotic supplements based on a greater understanding of the incredible diversity of the human gut, coupled with a deeper appreciation for how humans and their commensal “helper” bacteria work together to produce a healthy system.

Soil-based bacteria have a three-stage life cycle, with each stage triggered by nutrient availability: vegetative growth, sporulation, and germination. The sporulation phase is particularly relevant to its potential as a probiotic. The spore structure preserves the bacteria in a dormant phase and against any harm whether in any terrestrial environment or in the acidic environments of the stomach and upper intestines. When these probiotic microbiota are ingested, they travel all the way to the lower intestine where they come alive. Like a seed, warm temperatures, moisture, and nutrients stimulate the germination stage where bacteria emerges from dormancy. Soil-based probiotics are well-adapted to the environment of the gut, and have been shown to remain in the digestive tract where they can provide long term benefit.

SBO probiotics are characterized by two traits that make them superior to other probiotics: 1) the spore phase enabling natural resistance to the harsh environment of the upper digestive tract and stomach, and 2) inherent environmental stability that does not require the addition of specialized coatings or preservatives to ensure a clinically relevant amount reaches the appropriate areas of the gut.

Though SBO probiotics are based directly on symbiotic communities of bacteria found in natural soil environments, these organisms are not harvested directly from the earth to be packaged as a supplement. They are instead produced in a safe, monitored environment to ensure specificity of the strains.

Why are soil-based probiotics so popular among clinicians, and what makes them so important?  The answer to this question lies in an understanding of the human gut microbiome.

MULTI-STRAIN BACILLUS COMPLEX

Bacteria are incredibly ubiquitous, highly adaptable ancient life forms that evolved relatively unchanged over nearly 4 billion years. Bacillus, in particular, is arguably Earth’s most resilient bacteria―the oldest of which having been cultured and identified from the abdominal contents of extinct bees preserved in amber for 25 to 40 million years.

Through diet and lifestyle, our earliest ancestors were routinely exposed to bacillus spores found in healthy soils and our natural environment. Yet we no longer have routine exposure to bacillus spores due to the hyper-sanitization of our post-industrial civilization. Terraflora’s unique probiotic + prebiotic bio-complex of commensal bacillus strains reconnect humans with their ancestral environment.

Terraflora bridges the lost connection to our natural environment, with a sophisticated probiotic bio-complex of specific, commensal Bacillus strains. Selected for their unique characteristics, Bacillus are gram-positive bacteria that can exist in two forms. Under favorable conditions the bacteria grow in a vegetative form, but when starved of nutrients they differentiate into a dormant life form known as an “endospore” or simply a “spore”. These spores come alive when introduced to an ideal environment, like the human gut.

Terraflora’s innovative DNA verified strain combination introduces Ribospore™ (Bacillus pumilus) and Bacillus megaterium EM144™, microorganisms scientifically proven to effectively produce highly bioavailable antioxidants and riboflavin, right at the site of absorption. Riboflavin is an essential nutrient for maintaining a healthy digestive tract.

In addition to our proprietary new RibosporeTM (Bacillus pumilus) and Bacillus Megaterium EM144TM—Bacillus subtilis, Bacillus clausii, and Bacillus coagulans complete Terraflora’s multi-strain probiotic bio-complex.

ADVANCED PREBIOTIC BIO-COMPLEX


Terraflora™ contains a prebiotic blend of certified organic, wild-harvested seaweeds, mushroom extracts, and humic acid. These ancient, food-based prebiotics support commensal microbiota with a diverse spectrum of naturally-occurring polyphenols and polysaccharides designed to strengthen healthy intestinal flora. This bio-complex includes:

LARCH ARABINOGALACTAN: A solvent-free water extract that retains all bioactive polyphenolic flavonoids present in Larch, including taxifolin and quercetin. Larch arabinogalactan is a densely branched, non-starch polysaccharide consisting of galactose and arabinose molecules. It has been shown to increase production of critical short-chain fatty acids (SCFAs) such as butyrate in the gut. Butyrate is the principle fuel for intestinal cells and supports healthy tight junctions in the gut lining. In addition, Larch arabinogalactan enhances beneficial gut flora and increases levels of beneficial intestinal anaerobes, particularly Bifidobacterium longum.

FUCUS VESICULOSUS (BLADDERWRACK) & UNDARIA PINNATIFIDA (WAKAME) EXTRACTS: These are certified organic solvent-free water extracts that are wild-harvested from clean ocean waters of Patagonia and Nova Scotia. They are rich in marine polyphenols and complex, sulfated, fucose-rich polysaccharides called fucoidans. Fucoidans are found in edible brown seaweeds and are shown to have multiple bioactivities including the support of healthy inflammation response in the GI tract. In vitro studies show that fucoidan effectively inhibits adhesion of pathogenic bacteria Helicobacter pylori and Escherichia coli to human cells. Furthermore, they increase the abundance of beneficial bacteria and significantly decrease inflammatory response and antigen load of the gut microbiota. In addition, they may also help maintain levels of beneficial bacteria in the gut during antibiotic use and are known to increases the integrity of tight junctions in the gut lining.

NORDIC CHAGA EXTRACT: This ingredient is a certified organic hot-water extract obtained exclusively from the mushroom fruiting body. It is sustainably wild-harvested in the Arctic (Finnish Lapland forest) and contains a diverse spectrum of polysaccharides and polyphenols. This extract has been shown to help protect against acute colonic inflammation and shown to decrease the Firmicutes-to-Bacteroidetes bacterial ratios. Decreased Firmicutes-to-Bacteroidetes ratios are significantly associated with lower body mass index (BMI).

RED REISHI EXTRACT: A certified organic extract obtained by traditional hot-water extraction methods exclusively from the mushroom fruiting body. It contains a diverse spectrum of polysaccharides and polyphenols that have been shown to increase microbiota richness and regulate intestinal barrier function. It is known to support the health of the gut lumen. Furthermore, is has been shown to decrease Firmicutes-to-Bacteroidetes ratios and endotoxin-bearing Proteobacteria levels.

HUMIC ACID: The humic acid in Terraflora is water extracted from ancient freshwater humate deposits. It has been shown to significantly increase the overall concentration of colonic microbiota.

TERRAFLORA INGREDIENTS

Probiotic Bio-Complex: 1 Billion Viable Cells per serving
Ribosporea  (Bacillus pumilus)
Bacillus megaterium EM144a
Bacillus subtilis
Bacillus clausii
Bacillus coagulans


Prebiotic Bio-Complex: 850 mg per serving
Larch Arabinogalactan (Larix spp.), Reishi (Ganoderma lucidum) Extract (fruiting body), Wild-Harvested Chaga (Inonotus obliquus) Extract (fruiting body), Wild-Harvested Nova Scotian Bladderwrack (Fucus vesiculosus) Extract (thallus), Wild-Harvested Patagonian Wakame (Undaria pinnatifida) Extract (sporophyll), and Humic Acids.

Other Ingredients: Plant cellulose (veggie capsule)

Contains No: dairy, wheat, yeast, gluten, corn, sugar, soy, shellfish, tree nuts, or GMOs. Made without stearates, fillers, binders, flow agents, or additives of any kind.

DIRECTIONS

Serving Size: Two Veggie Capsules            Servings Per Container: 30

Suggested Use: Take 1–2 capsules per day with or without food, or as recommended by your health care professional.

If you are pregnant, nursing, or have a medical condition, consult your healthcare practitioner before use.

REFERENCES

  1. Paper regarding the use of mushroom extracts as prebiotics:

    A Critical Review on Health Promoting Benefits of Edible Mushrooms through Gut Microbiota
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618583/

    Abstract
    Mushrooms have long been used for medicinal and food purposes for over a thousand years, but a complete elucidation of the health-promoting properties of mushrooms through regulating gut microbiota has not yet been fully exploited. Mushrooms comprise a vast, and yet largely untapped, source of powerful new pharmaceutical substances. Mushrooms have been used in health care for treating simple and common diseases, like skin diseases and pandemic diseases like AIDS. This review is aimed at accumulating the health-promoting benefits of edible mushrooms through gut microbiota. Mushrooms are proven to possess anti-allergic, anti-cholesterol, anti-tumor, and anti-cancer properties. Mushrooms are rich in carbohydrates, like chitin, hemicellulose, β and α-glucans, mannans, xylans, and galactans, which make them the right choice for prebiotics. Mushrooms act as a prebiotics to stimulate the growth of gut microbiota, conferring health benefits to the host. In the present review, we have summarized the beneficial activities of various mushrooms on gut microbiota via the inhibition of exogenous pathogens and, thus, improving the host health.

    2. Paper regarding the use of Seaweeds as prebiotics:
    Prebiotics from Marine Macroalgae [seaweeds] for Human and Animal Health Applications
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2920542/

    Abstract
    The marine environment is an untapped source of bioactive compounds. Specifically, marine macroalgae (seaweeds) are rich in polysaccharides that could potentially be exploited as prebiotic functional ingredients for both human and animal health applications. Prebiotics are non-digestible, selectively fermented compounds that stimulate the growth and/or activity of beneficial gut microbiota which, in turn, confer health benefits on the host. This review will introduce the concept and potential applications of prebiotics, followed by an outline of the chemistry of seaweed polysaccharides. Their potential for use as prebiotics for both humans and animals will be highlighted by reviewing data from both in vitro and in vivo studies conducted to date.

    3. Paper regarding the use of Humic Acids as prebiotics:
    Impact of humic acids on the colonic microbiome in healthy volunteers
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2920542/

    Abstract
    AIM: To test the effects of humic acids on innate microbial communities of the colon.
    METHODS: We followed the effects of oral supplementation with humic acids (Activomin®) on concentrations and composition of colonic microbiome in 14 healthy volunteers for 45 d. 3 × 800 mg Activomin® were taken orally for 10 d followed by 3 × 400 mg for 35 d. Colonic microbiota were investigated using multicolor fluorescence in situ hybridization (FISH) of Carnoy fixated and paraffin embedded stool cylinders. Two stool samples were collected a week prior to therapy and one stool sample on days 10, 31 and 45. Forty-one FISH probes representing different bacterial groups were used.
    RESULTS: The sum concentration of colonic microbiota increased from 20% at day 10 to 30% by day 31 and remained stable until day 45 (32%) of humic acid supplementation (P < 0.001). The increase in the concentrations in each person was due to growth of preexisting groups. The individual microbial profile of the patients remained unchanged. Similarly, the bacterial diversity remained stable. Concentrations of 24 of the 35 substantial groups increased from 20% to 96%. Two bacterial groups detected with Bac303 (Bacteroides) and Myc657 (mycolic acid-containing Actinomycetes) FISH probes decreased (P > 0.05). The others remained unaffected. Bacterial groups with initially marginal concentrations (< 0.1 × 109/mL) demonstrated no response to humic acids. The concentrations of pioneer groups of Bifidobacteriaceae, Enterobacteriaceae and Clostridium difficile increased but the observed differences were statistically not significant.
    CONCLUSION: Humic acids have a profound effect on healthy colonic microbiome and may be potentially interesting substances for the development of drugs that control the innate colonic microbiome.

2

THE NEED FOR IODINE SUPPLEMENTATION

Dr. Hank Liers PhD iodine supplementationFred Liers PhD iodine supplementationThe Orthomolecular Medicine News Service (OMNS) published on June 12 “The Need for Iodine Supplementation.” We believe strongly in the need for iodine supplementation, especially given the fact that more than 90% of the US population is iodine deficient. For this reason we make available both Nascent Iodine and Lugol’s Iodine Solution 2 to our customers.

We present the full OMNS article (below), as a source of valuable information to our resellers and Creating Health Naturally readers. The factors contributing to massive-scale iodine deficiency remain virtually unchanged over decades. This has led to a greater need for educating health professionals and individuals about the critical importance of iodine supplementation.

Another useful article discussing the benefits of iodine supplementation was published August 2 by Dr. Mark Sircus, OMD: “Iodine, Thyroid and Low Body Temperature.” ~

The Need for Iodine Supplementation

by Wojciech Rychlik, PhD

(OMNS, June 12, 2017) Feeling tired, having low energy or depression, gaining weight, memory problems, having dry skin, dry mouth, or immune system issues? There is good chance your body needs iodine supplementation. Why iodine? Because this essential to human health element has been singled out as dangerous, for several obscure reasons, and it has been gradually eliminated from our diet, and even worse, replaced by its antagonist, bromine. This trend has been termed, iodophobia (1). It is a cause of widely occurring hypothyroidism in many developed countries.

Iodine: How Much?

Iodine deficiency is associated with (2, 3, 4):

  • Fibrocystic breast disease leading to breast cancer and stomach cancer
  • Goiter (enlarged thyroid)
  • Mental issues from reduced alertness, lowered IQ, autism to cretinism, lack of iodine for the fetus leads to cretinism, and in milder cases to autism and ADHD
  • Slow metabolism, leading to tiredness, sluggishness, fatigue, apathy, depression, and insomnia
  • Inability to produce saliva, dry skin, and lack of sweating
  • Lack of optimal detoxification, especially of bromides, fluorides, and heavy metals
  • Sensitivity to temperature changes, and cold hands and feet
  • Muscle pain, fibrosis, and fibromyalgia
  • Erectile dysfunction, infertility and miscarriages, and low sex drive
  • Overweight
  • High blood pressure, and increased incidence of heart attacks and strokes

The Food and Agriculture Organization (FAO) of the United Nations has published probable safe upper limits for dietary intake of iodine (5). They range from 150 micrograms (mcg) per kilogram (kg) per day in newborn infants to 30mcg/kg/day in adults. That is 2 milligrams (2,000 micrograms) daily for a 146-pound adult. The safe upper limit is higher during pregnancy and lactation (40 mcg/kg/day).

Treatments for Hypothyroidism

The simplest method to deal with an underactive thyroid is proper supplementation with iodine, called orthoiodosupplementation. If the thyroid is damaged, then supplementation with thyroid hormones, thyroxine (T4) and triiodothyronine (T3, the main biologically active hormone) may be necessary. Supplementation (6). with these hormones should be done under close supervision of a medical professional. However, supplementation with inorganic iodine is generally much safer, as the body “knows” how much T4 and T3 need to make. There are also drugs that change physiology of iodine metabolism, but this subject is beyond the scope of this article. Pharmaceutical companies pressure doctors to avoid inexpensive orthoiodosupplementation, so you won’t likely get a prescription for inexpensive Lugol’s solution from a mainstream practitioner.

One caveat to supplementation with iodine is the autoimmune illness called Hashimoto’s disease, or chronic lymphocytic thyroiditis, which is one of the potential causes of hypothyroidism. Unfortunately, when hypothyroidism is diagnosed, the possibility that Hashimoto’s disease underlies this condition has not always been properly tested. Therefore, Hashimoto’s disease has often been misdiagnosed. Doctors usually treat this condition with hormone replacement therapy, and some believe that excessive iodine intake may trigger it in susceptible people (7). Always ask your doctor if iodine supplements are right for you.

History of Iodine Usage and “Iodophobia”

This subject has been covered in detail by Dr. Guy E. Abraham (8,9,10). The iodine element was discovered in 1811 by B. Courtois. In 1850–1853 A. Chatin noted that goiter and cretinism are rare in geological zones rich in iodine and frequent where iodine is in short supply, and that goiter can be prevented by iodine supplementation. In 1895 E. Baumann proposed that iodine is the active element in the thyroid gland.

By the time Bauman identified large concentrations of iodine in the thyroid gland in 1895, pharmaceutical and apothecary preparations containing iodine, excluding thyroid extracts, were widely used as a panacea.

To quote Kelley: (11) “The variety of diseases for which iodine was prescribed in the early years is astonishing – paralysis, chorea, scrofula, lacrimal fistula, deafness, distortions of the spine, hip-joint disease, syphilis, acute inflammation, gout, gangrene, dropsy, carbuncles, whitlow, chilblains, burns, scalds, lupus, croup, catarrh, asthma, ulcers, and bronchitis – to mention only a few. Indeed, tincture of iodine, iodoform, or one of the iodides, was applied to almost every case that resisted the ordinary routine of practice; and between 1820 and 1840 there appeared a remarkable series of essays and monographs testifying to the extraordinary benefits to be achieved by this new and potent remedy.”

Unfortunately, these monographs have virtually disappeared from US medical libraries. In the mid-1800s, iodine treatments of some diseases called for ingestion of gram (1,000 mg) amounts per day. However, most treatments were from 5 to 50 mg daily. The recommended daily amount of iodine by Dr. G. E. Abraham is 0.1-0.3 ml Lugol containing 12.5-37.5 mg elemental iodine. This is the amount of iodine needed for whole body sufficiency, based on a recently reported iodine/iodide-loading test (12). Thyroid gland sufficiency for iodide is achieved with a lower dose.

Lugol's iodine supplementation

The first iodophobic authority emerged in early 1900s. Prof. T. Kochler reported that he suffered from overactive thyroid following ingestion of iodide (just a single individual case, not a statistical research study!) Despite this, the number of applications grew. In an International Index published in 1956, and devoted exclusively to iodine pharmaceuticals, no less than 1,700 approved iodine-containing products were listed. In 1948 Wolff and Chaikoff published that a serum inorganic iodide level at a concentration of 1 µM blocks (one micromolar) the synthesis of thyroid hormones, resulting in hypothyroidism and goiter in rats. But this conclusion was erroneous as they even did not measure thyroid hormones in the rats studied, and of course, hypothyroidism and goiter were not observed in those rats. Many organic forms of iodinated drugs were quite poisonous. Unfortunately, medical establishment did not make a distinction between organic and inorganic forms of iodine, and iodophobia became more popular.

Decades ago, iodine was added to bread so that one slice contained 150 mcg of iodine (the current recommended daily allowance). In the 1980s, bromine replaced iodine in bread. Since bromide is an antagonist to iodine (it is goitrogenic), it worsened iodine deficiency in the US. Moreover, a big push to remove salt from our diet (the only grocery item still supplemented with iodine) exacerbated the problem. The only developed nation that resisted iodophobia is Japan, statistically the healthiest and longest living nation on the planet. Their average daily consumption of iodine is around 5 mg, with various reports ranging from 1 mg to 18 mg. In a study of reported daily iodine intake versus total number of clinical symptoms, an intake of approximately 1 mg per day correlated with the lowest number of reported symptoms, that is, the highest level of health (13). Recent popularization of bromides in our food supplies likely increased this amount.

According to Dr. Abraham, (14) “proper amounts of iodine in the food supply should be considered one of a nation’s greatest assets. Removing iodine from the food supply is a major mistake. Supplying a daily intake of iodine sufficient for the whole body (100-400 times the RDA) gives protection against goitrogens and radioactive iodine/iodide fallout; improves immune functions, resulting in an adequate defense system against infection; decreases singlet oxygen formation which is the major cause of oxidative damage to DNA and macromolecules, resulting in an anticarcinogenic effect in every organ; results in a detoxifying effect by increasing urinary excretion of the toxic metals lead, mercury, cadmium, and aluminum, as well as the goitrogens fluoride and bromide; normalizes hormone receptor functions resulting in improved response to thyroid hormones both endogenous and exogenous; and results in better control of blood sugar in diabetic patients; stabilizes cardiac rhythm, obviating the need for the toxic sustained release form of iodine, amiodarone; and normalizes blood pressure without medication in hypertensive patients. Iodine deficiency is the major cause of cognitive impairment, worldwide.”

The Iodine-Cancer Connection

The body requires iodine to metabolize both omega-3 and omega-6 fatty acids. A substance called delta-iodolactone, a derivative of arachidonic acid, which is produced in the thyroid gland and breast tissue, prostate, colon, and the nervous system, is a regulator of a process called cellular apoptosis (“cell death”). Ascorbic acid is required to stimulate intracellular hydrogen peroxide synthesis that, in turn, provides the energy to make iodine free radicals necessary for this reaction. When the level of delta-iodolactone is high enough, the process of apoptosis can then kill cancer cells. (15)

Unfortunately, the recommended daily allowance (RDA) for iodine — about 150 mcg per day — will not allow delta-iodolactone to be efficiently formed in the thyroid gland. The thyroid requires higher iodine concentrations to efficiently produce it. Researchers have found that 100 times the RDA amount of iodine is optimal to produce delta-iodolactone. That equates to taking about 15 mg of iodine per day (15,16). These findings are important because they imply that there are some biochemical reactions that require much larger amounts of iodine than the current RDA. The mechanism by which delta-iodolactone induces cell death may be an important pathway for curing some types of cancer.

Forms of Iodine

Inorganic iodine exists in 6 oxidative states, from -1 to +7. The most reduced form (with most electrons) is iodide (I); an example is potassium iodide. The diatomic form of elemental iodine I2, has no electrical charge. Monoatomic iodine also has no electrical charge, but is unstable and highly reactive (free radical, labeled as an I with a dot, I* ). It can be produced by exposing I2 to ultraviolet light. Electric and magnetic fields won’t do it, as is sometimes incorrectly suggested. More oxidized forms of iodine are: hypoiodite (I+1), iodite (I+3), iodate (I+5), and periodate (I+7). The body’s metabolism may convert (reduce) these forms to biochemically available iodide, but at the cost of depleting its antioxidants. All forms of positively charged iodine are relatively poisonous, with established lethal doses (LD50) in the range of 35 to 2100 mg/kg. Elemental iodine (I2) and iodides (I) are non-poisonous. However, a bad “antiseptic” non-culinary taste of iodine (I2) suggests to our senses that this is not so good choice for supplementation.Nascent iodine supplementation

Despite that adverse taste, almost all the research on iodine supplementation has been done using Lugol’s Solution (17). The original solution is called 5% Lugol’s Iodine, but in reality it consists of 12.5% iodide/iodine or (I/[I3]) ions. Two drops of Lugol’s Solution (0.1 ml) contain 12.5 mg iodine/iodide mix. Iodine tablets that are a solid form of Lugol’s solution, were created to mask the taste and make the doses more precise for dietary supplementation.

I should mention a few points about Edgar Cayce’s atomidine. This famous visionary wrote several articles about the best form of iodine supplement (18). Some claim that this was iodine trichloride, but that cannot be true as this compound is toxic by ingestion and damaging to mucous membranes. It decomposes to ICl and poisonous gas Cl2 at 77 degrees C and also in water at room temperature (19). Most likely Cayce’s atomidine was simply a 1% iodine solution (I2) in 95% ethanol. I am surprised that there are educated people, even medical doctors who claim that “elemental monoatomic iodine” preparations (Atomidine, Nascent Iodine etc.) are the best forms of iodine supplements. May be it has something to do with efficient marketing? Elemental Iodine (I2) is soluble in glycerin. Replacement of ethanol with glycerol indeed makes these supplements more consumption-friendly, so they are sold by some vendors as superior products to Cayce’s ethanol-formulated one. Personally, I think glycerol-based I2 supplements are inferior to iodides; however, they are excellent antiseptics.

To defend the validity of Cayce’s vision, in thyroid, I ion and amino acid tyrosine react through a short intermediate step by forming monoatomic I* free radical (selenium and hydrogen peroxide are involved) to make monoiodotyrosine. Diiodotyrosine is formed analogical way, and finally, two of these molecules combine to produce thyroxine. All those steps are carried by the enzyme thyroid peroxidase, which is normally attached to the protein thyroglobulin. So, yes, monoatomic iodine I* exists in human bodies, and it directly reacts with tyrosine, but no, it wouldn’t be healthy to consume iodine free radicals as their high reactivity would prevent safe transport throughout the body.

In the mid-1930s the thyroid hormone thyroxine became available on the market. This was a blessing for people who had damaged their thyroid. Unfortunately, doctors started to prescribe this hormone to just about anybody with hypothyroidism, thinking that they can control better thyroid hormone levels than our bodies can. And, the “iodine is iodine, no matter what form” mentality became a dangerous trend, because most medical professionals do not fully appreciate the difference between the raw nutrient (iodine) and its product (hormone).

The pharmaceutical industry came up with lots of organic forms of iodine (NB: organic, meaning that iodine is bound to a carbon-atom-containing molecule and NOT meaning it’s grown in a pesticide-free environment), all relatively toxic and certainly not to be used without strict medical supervision. Only inorganic forms of iodine, I and I2, are safe for supplementation (20,21). Further, high doses of these supplements should still be supervised by your doctor.

Iodine Uses

Iodine plays critical role in human metabolism. Many researchers believe the RDA value of 150 mcg for iodine is too low, especially when this element is commonly substituted with competing element bromine. Therefore, the main use of iodine in dietary supplementation is to enable optimal thyroid function. There are a number of medical conditions where iodine is either essential or helpful. For best results, iodine/iodide should be supplemented with selenium, magnesium, copper (there is usually enough of it in tap water as copper is widely used in plumbing), vitamin B2 (riboflavin) and B3 (niacin). Ask your doctor before taking any iodine supplements, especially if you are on medications.

Elemental iodine (I2) is antibacterial and antifungal, so iodine or iodine/iodide solutions are commonly used topically to sterilize wounds, or internally to fight infections, such as vaginitis and sore throat, and also to sanitize drinking water. Because iodine is antibacterial, drinking it may cause friendly bacterial flora to suffer and result in diarrhea and stomach cramps (the same applies to Lugol’s solution, but to a lesser extent as it contains iodides as well).

Ingestion of iodides prevents the incorporation of destructive radioactive iodine into the body (mainly by the thyroid) in case of nuclear accidents. It also may help flushing already incorporated radioactive iodine from the thyroid, although too much iodine inhibits secretion of T4/T3 from the gland.

Common-Sense Cautions

Overdosing any of the iodine supplements can lead to swollen salivary glands, metallic aftertaste and skin rash and itching (that are usually due to rapid process of detoxification from heavy metals fluorides and bromides), faster heartbeat or palpitations and diarrhea. When supplementation is stopped, these symptoms will usually disappear quickly, often within one day. Iodine stabilizes thyroid hormone production, so it is an adaptogen, but in rare cases, such as acquired allergy to iodine (Hashimoto’s disease), it may actually misbalance it. In some cases, iodine supplementation can cause hypothyroidism, so it’s important to get checked by your doctor to make sure that your thyroid function is not worsened by supplementation. Some authors advising caution are Alan Christianson (22), Jeffrey Dach, (23) and Alan Gaby (24). Testing of levels of thyroid hormones along with testing and supplementation of mineral nutrients such as selenium, zinc, copper, magnesium calcium, and other trace minerals may prevent problems in cases where high doses of iodine/iodide might tend to cause Hashimoto’s disease. (23)

Inorganic Iodine Availability

The most common form of iodine supplement is Lugol’s solution (17). The original solution contains 5% of iodine and 10% iodide. Solid pill forms of Lugol’s solution are sold under several brand names. Potassium iodide (KI), my favorite iodine supplement, is available as tablets as well. Various products with kelp or other seaweed extracts contain iodides as well. Check the label when you buy as some of them are very diluted.

It is difficult to find inexpensive elemental iodine (I2) solution in alcohol. You can buy iodine crystals online and make the proper solution by yourself very easily (using either alcohol or glycerol). The monoatomic iodine concept is simply a marketing gimmick that has been created to inflate the price several fold. Note that if the monoatomic claims were really true, few would really want to drink free radicals, the only monoatomic form that exists. Iodine free radicals are not transported freely in our bodies because they are too reactive. Elemental iodine preparations, including iodine dissolved in glycerol, may be helpful products for external antiseptic use rather than a supplement.

Another form of iodine supplement includes a mixture of algae and thyroid extract in glycerin, water and ethanol. This is likely not harmful because it contains T3 and T4 only in very small amounts, and the recommended serving size is also small. Other complex formulae that contain elemental iodine are a useful antiseptic, but not a good supplement. Iodine trichloride should be avoided as a supplement because it is too toxic.(19)

Summary

The established RDA allowance for iodine (150 mcg/day) is inadequate for many individuals. In order to maintain optimum health, adults need 2-5 mg of iodide daily. Actually, this is in line with the upper safe limit of dietary intake of iodine established by FAO (30 mcg/kg/day). In case of a dysfunctional thyroid or other illnesses, such as fibrocystic breast disease or cancer, 15-50 mg daily may be needed. Ask your doctor about the alternatives to hormone therapy or taking iodine-containing organic drugs, because inexpensive orthoiodosupplementation would usually not be his/her first choice.

The best and safest form of iodine supplementation for a healthy adult is iodide. Iodides are naturally produced in larger quantities by various seaweeds.

Please consult your doctor about iodine supplementation, as in your particular case it may be contraindicated.

References:

1. Abraham GE. The History of Iodine in Medicine Part III: Thyroid Fixation and Medical Iodophobia. http://optimox.com/pics/Iodine/IOD-16/PUB_16.htm

2. Dommisse J. MD Best Kept Secret (2009) http://www.westonaprice.org/modern-diseases/best-kept-secret/#sthash.vdrKPaJw.dpuf

3. http://theiodineproject.webs.com/addadhdautism.htm

4. Hamza RT1, Hewedi DH, Sallam MT. (2013) Iodine deficiency in Egyptian autistic children and their mothers: relation to disease severity. Arch Med Res. 44(7):555-61. http://www.ncbi.nlm.nih.gov/pubmed/24120386

5. http://www.fao.org/docrep/004/y2809e/y2809e0i.htm

6. Abraham GE. The Concept of Orthoiodosupplementation and Its Clinical Implications. https://www.optimox.com/pics/Iodine/IOD-06/IOD_06.htm

7. http://www.webmd.com/women/hashimotos-thyroiditis-symptoms-causes-treatments#1

8. Abraham GE. The History of Iodine in Medicine Part I: From Discovery to Essentiality. http://optimox.com/pics/Iodine/IOD-14/PUB_14.htm

9. Abraham GE. The historical background of the Iodine Project. http://www.optimox.com/pics/Iodine/IOD-08/IOD_08.htm

10. Abraham GE. The History of Iodine in Medicine Part II: The Search for and the Discovery of Thyroid Hormones. http://optimox.com/pics/Iodine/IOD-15/PUB_15.htm

11. Kelly FC. “Iodine in medicine and pharmacy since its discovery , 1811-1961.” Proc R Soc Med, 1961; 54:831-836. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1869599/

12. Abraham GE. “The safe and effective implementation of orthoiodosupplementation in medical practice.” The Original Internist, 2004; 11(1):17-36. http://www.hakalalabs.com/Research/Abraham_OI_Mar04.pdf

13. Fallon Morell S. The Great Iodine Debate (2009) The WestonA. Price Foundation, http://www.westonaprice.org/modern-diseases/the-great-iodine-debate/

14. Abraham GE. The Wolff-Chaikoff Effect: Crying Wolf? https://www.optimox.com/pics/Iodine/IOD-04/IOD_04.html

15. Brownstein D. The Cancer-Iodine Connection, (2015) http://www.newsmax.com/Health/Dr-Brownstein/iodine-cancer-cell-death-fish-oil/2015/06/10/id/649877/

16. 6-Iodolactone, key mediator of antitumoral properties of iodine, M. Nava-Villalba, C. Aceves, (2014) Prostaglandins & Other Lipid Mediators 112, 27-33. https://www.researchgate.net/publication/263856609_6-Iodolactone_key_mediator_of_antitumoral_properties_of_iodine

17. Bacteriological Analytical Manual, R40 Lugol’s Iodine Solution (2001), http://www.fda.gov/Food/FoodScienceResearch/LaboratoryMethods/ucm062245.htm

18. Review of Atomidine, International Wellness Directory, http://www.mnwelldir.org/docs/reviews/atomidine.htm

19. Material safety data sheet, http://www.mnwelldir.org/docs/history/Iodine_Trichloride.pdf

20. Abraham GE. The historical background of the Iodine Project http://www.optimox.com/pics/Iodine/IOD-08/IOD_08.htm

21. Abraham GE and Brownstein D. A Rebuttal of Dr. Gaby’s Editorial on Iodine. (2005) Townsend Letter, The Examiner of Alternative Medicine, http://www.townsendletter.com/Oct2005/gabyrebuttal1005.htm

22. Christianson A. http://www.integrativehealthcare.com/why-i-discourage-high-dose-iodine/

23. Dach J. http://jeffreydachmd.com/iodine_is_safe

24. Gaby A. http://www.townsendletter.com/AugSept2005/gabyiodine0805.htm

Nutritional Medicine is Orthomolecular Medicine

Orthomolecular medicine uses safe, effective nutritional therapy to fight illness. For more information: http://www.orthomolecular.org

Access the original OMNS article, “The Need for Iodine Supplementation”: http://www.orthomolecular.org/resources/omns/v13n14.shtml

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RELIEF Rx™ REMEDY FOR MUSCLES, SKIN, AND JOINTS

Dr. Hank Liers, PhD Relief Rx™ pain sore musclesOne of our suppliers recently sent me a new product sample called Relief Rx™ to evaluate. The product is a topically-applied fast-acting “Aloe vera relief gel” for sore muscles, back, joints, and skin.

ReliefRx

After I applied the gel to painful or sore spots on my body, my pain and soreness was relieved in a short time — 15 minutes or less! I was quite impressed, needless to say. The gel has no odor and after it dries, it leaves no messy oils etc. on your skin—unlike many other topical skin formulas.

Because Relief Rx™ is a new product there are no prior sales data. However, our supplier also sent product samples to many other people who agreed to try it. The results experienced by the testers were nothing short of amazing — see some of their testimonials below.

 

 

RELIEF Rx™ INGREDIENTS

Aloe vera, a primary ingredient in Relief Rx™

Aloe vera is a primary ingredient in Relief Rx™

Aloe vera (organic)

The Egyptians called Aloe vera the “plant of immortality.” Aloe has been cultivated for centuries by indigenous people from Africa to Asia, and it is revered around the world by herbalists. As such, it may be the ultimate resource nature has provided for natural health.

The aloe extract in Relief Rx™ is carefully prepared with 100% organically grown plants, then compounded with a proprietary process to provide highly bioavailable constituents, such as acemannan and a full-spectrum of natural polysaccharides. Some of the known helpful effects of acemannan include:

  1. Helps cells to be more resistant to viruses and pathogenic bacteria.
  2. Improves overall cellular metabolism and functioning.
  3. Promotes healthy inflammation response.
  4. Provides critical lubrication of joints.
  5. Reduces pain.
  6. Improves vascular flow.
  7. Reduces scarring.
  8. Improves healthy macrophage activity.
  9. Increases the body’s own production of interferon, interleukins.
  10. Increases the number and activity of killer T-cell and increase monocyte activity.
  11. Fights fungal infections, such as: Athlete’s foot, Ringworm, Pruritus anivalvae, Balnea, Essential Pruritus, and Vaginal yeast infections/
  12. Helps athletic injuries such as: Muscle cramps, Sprains, Strains, Bruises, Swelling, Soreness, Tendonitis, and Bursitis.
  13. Helps with harmful organisms.
  14. Speeds wound healing..
  15. Anti-aging properties. Stimulate fibroblasts to release collagen and elastin to make new tissue.

You will feel the quality of the Aloe vera at work with every application.

Hemp

Hemp

Hemp Oil:
The hemp oil in Relief Rx™ is extracted from the flowers and leaves of the revered hemp plant. It is especially rich in bioactive molecules (without any psychotropic effects or side effects) and has gained worldwide recognition as a natural and potent therapeutic nutrient.

Select hemp oil molecules interact with our inherent endogenous cannabinoid (endocannabinoid) system to carry out beneficial and protective physiological reactions. First discovered in the late 1980s, the endocannabinoid system supports the body’s complex regulatory mechanisms including mood, sleep, appetite, hormones, pain, and immune response.

Relief Rx™ utilizes an advanced proprietary science that greatly enhances the efficacy of hemp oil to achieve results that are unequaled by conventional products.

White Willow Bark Extract (Salix alba)

White Willow Bark Extract (Salix alba)

White Willow Bark Extract (Salix alba):
A native of Europe and Asia, the name of this deciduous tree comes from the lightly colored undersides of its slender leaves. Willow may in fact be one of the oldest remedies, used in ancient Egypt and China as early as 500 BCE.

Healers applying skin and beauty treatments understood that willow bark was an important ingredient in the support of natural health. Careful processing ensures that the willow extract in Relief Rx™ contains the highest purity of ingredients. Benefits of using white willow bark extract include:

  • Anti-aging: A 2010 study reported that salicin can help reduce the appearance of skin aging. Researchers applied a serum product containing 0.5 percent salicin on the faces of women aged 35 to 70, every day for 12 weeks. Results showed improvements in the appearance of wrinkles, pore size, radiance, and overall appearance after only one week.

  • Helps cleanse oily skin: Willow bark extract naturally exfoliates skin and clears pores to give skin a clearer, healthier appearance.
  • Smooths the appearance of fine lines and wrinkles: The same exfoliating action that reduces clogged pores also helps smooth the look of fine line and wrinkles. Willow bark is a source of natural hydroxy acids that gently exfoliate. The result is smoother, softer skin.
  • Antioxidants: Like most plant extracts, willow bark contains flavonoids and tannins—powerful antioxidants that help protect skin from environmental stressors.
Relief Rx™ contains important trace minerals

Relief Rx™ contains important trace minerals

Ionic Trace Minerals Blend:
There is a great deal of evidence that the healthy function of the body is strongly influenced by electrical impulses. That is, our bodies use electrical impulse pathways, and electrolytes and ions are the conductors of these currents maintaining a smoothly running body. Ions provide the necessary charge of both positive and negative molecules that keep the electrical component of the human battery “charged” and working in top form.

The human skin is the largest organ of the body and is highly involved in the detoxification and maintenance processes of health. Skin not only excretes and eliminates toxins; it also has a tremendous capacity to absorb health supportive substances.

Clinical researchers have continued to document the clinical findings that have been observed for decades when it comes to the healing properties of topical minerals. Many of the studies on therapeutic baths have used minerals from the Dead Sea as well as the Great Salt Lake. Of particular interest are the powerful effects of these salts that exhibit favorable effects in inflammatory disease.

In one study, 103 arthritic patients received various bath treatments with ionic trace minerals. The study showed impressive results and those with the greatest physical limitation had the most pronounced improvement. A large percentage of the patients reported having less pain, improved mobility and were able to decrease analgesic use. In a different double-blind study, the use of warm mineral baths demonstrated a lasting effect for patients suffering from degenerative arthritis.

In a clinical trial conducted by a leading research university in Germany, patients with atopic (eczema) skin disorders immersed their arms in a mineral rich bath. The participants immersed one arm in tap water the other in the therapeutic mineral rich bath. The findings showed that skin hydration was improved and skin roughness and inflammation was reduced when immersed in the mineral rich water.

RELIEF Rx™ USAGE

Direction for use:
Apply a generous amount of gel to stressed muscles and joints as needed for soothing harmonious comfort, creating a moist surface. Allow the moisture to absorb naturally into the skin and air dry on its own. Keep tightly sealed and away from children. For external use only.

Ingredients:
Purified water, Glucomannan, Organic Aloe vera, Ionic Trace Elements Blend, Hemp Oil, White Willow Bark Extract, Citric Acid, Potassium Sorbate, Sodium Benzoate.

RELIEF Rx™ TESTIMONIALS

Relief Rx™ is a new product with no prior sales data. The product was sent out to a number of people who agreed to try it. The results obtained were amazing as shown in the testimonials given below. Personally, we can confirm that the product works extremely well for a variety of muscle and joint issues – usually providing sustained relief within a short time after applying the gel to the skin.

1. Ole G., Topanga, California: “I am an 88-year old retired mechanical engineer with multiple knee, hip and upper back chronic discomfort, that is UNTIL I FOUND Relief Rx. All of it was gone in a matter of minutes. I now use this gel only when I over exert myself during yard work and gardening. I love this product…!!”

2. Paul G.: “In all of my 35+ years in the fitness facility business I never saw a relief product that works as good as Relief Rx™. This stuff is on the verge of being miraculous……truly amazing”

3. Charlie L: “I had a slight tear in the meniscus of my left knee that bothered me if I stood or sat for long. I applied Relief Rx™, and was amazed. In less than 20 seconds – literally, my knee was back to normal. I wasn’t expecting it to work that well or that quickly.”

4. Katie L (49): “I have used the Relief Rx™ many times when my muscles have been sore or my joints achy and each time, within minutes, the pain has diminished if not gone away completely. I don’t really understand why this happens, I just know it does. I appreciate the simplicity of the liquid – it is not thick, or smelly or difficult to use. And it seems to absorb quickly. It does not leave behind residue, any fragrance or greasy feeling. So I’m not so sure what is in it. I just know that it works wonders. Thank you for bringing this product to market. I’ve thrown out all of my other products and just use this.”

5. J.G.: “I have had severe pain in my right hand for over two years from using the mouse, pain in my arm, and recently I had surgery and developed a very uncomfortable pain on my right side from lying in bed. Every time I use Relief Rx™ I am amazed at how quickly the pain subsides and disappears. Thank you for this wonderful product!”

6. Dr. Chuck A.: “I applied Relief Rx™ on a patient that had nagging back issues. She told me she had “immediate and significant relief”. When can I get more?”

7. Mike G.: “I have played handball for 50 years. Over that time I have suffered right shoulder problem from injury, strain from over use, and tension from rotator cuff surgery. Over the past 15 years I have had to change shots due to shoulder problems and limitations. I applied Relief Rx™ and within 30 minutes I was 100%! I can hit all of the shots on the handball court like I could 15 years ago.”

8. U.: “This is the most amazing relief product I have ever experienced. I have disturbing problem in my back and it prevents me from getting a full nights sleep. Last night is the first night of continuous sleep I’ve had in more than a year.”