Dr. Hank Liers PhD gingko biloba extractHealth Products Distributors, Inc. (HPDI) has been carrying high-quality standardized Ginkgo Biloba extract (24/6) for more than 20 years. Ginkgo biloba extract is one of the best-selling herbal supplements in the United States and Europe because of its health benefits. Yet, because of severe price increases in ginkgo extract during the last few years, HPDI’s inventory was depleted. However, the price has now been greatly reduced for high-quality material—and we have inventory back in stock.

Ginkgo Biloba Tree

Ginkgo Biloba Tree

Ginkgo biloba has a long history of use (over thousands of years) in treating memory issues and blood disorders. Today, It is best known as a way to keep memory sharp. Laboratory studies have shown that Ginkgo biloba improves blood circulation by opening up blood vessels and making blood less sticky. Research studies also show that it is a powerful antioxidant.

Based upon these properties, Ginkgo biloba may improve blood vessel and eye health. Research has clearly shown that Ginkgo Biloba helps with dementia and poor circulation in the body. It also protects memory in older adults.


Ginkgo leaves contain flavonoids and terpenoids, which are both antioxidants. In your body, harmful free radical substances build up as you age and may contribute to a range of health issues. The antioxidants found in Ginkgo biloba help to neutralize free radicals, and prevent them from damaging DNA and other cellular structures.

Leaves of Ginkgo Biloba Tree

Leaves of Ginkgo Biloba Tree

Chemical constituents: Ginkgo biloba leaf contains a complex mixture of flavonoids including: quercetin, kaempferol, isorhamnetin and other glycosides. It also contains unique diterpenes including ginkgolides A, B, C and J, sesquiterpene bilobalide, and other natural compounds that contribute in a synergistic manner to the beneficial actions of Ginkgo biloba.

Our GINKGO BILOBA extract contains only the highest-quality 50:1 extract of ginkgo biloba standardized to 24% minimum ginkgoflavonglycosides and 6% minimum combined ginkgolides A, B, C, and bilobalide. Each capsule contains 120 mg of the extract and their are 60 capsules in a bottle. Other ingredients include: microcrystalline cellulose, HPMC (vegetarian capsule), and silica. The ginkgolic acid content of the current production run is is 1.36ppm.

Here is the Certificate of Analysis of our current run of Ginkgo Biloba.

Ginkgo Biloba extract

Ginkgo Biloba 120 mg



Reduces Conditions of Dementia: Scientific literature suggests that Ginkgo biloba extract benefits people experiencing cognitive decline, including those with dementia of Alzheimer’s disease (AD). Certain studies have found Ginkgo biloba can help improve cognitive performance and memory in both older and younger adults but might be especially useful for age-related mental decline.

Improves Concentration: Research shows that Ginkgo biloba extract can help combat poor concentration, reverse cognitive decline and and heal fatigue. It’s even useful for helping to treat cerebral insufficiency — a condition characterized by chronically low concentration, confusion, decreased physical performance, fatigue, headaches and mood changes.

Helps With ADHD: Some studies using therapies that include Ginkgo biloba have found relief and improved concentration for people with ADHD symptoms. And because it can improve concentration, memory and task performance, it may also reduce symptoms in people with dyslexia. There is also some evidence that ginkgo biloba can help reduce symptoms of autism, making it a potential autism natural treatment.

Helps with Headaches and Migraines: Ginkgo biloba can be an effective way to naturally reduce frequent headaches and the rate and severity of migraines because it reduces pain, increases blood vessel dilation and combats stress that can trigger problems. Headaches may be triggered by stress, fatigue, poor posture, drugs, low blood sugar, hormones, constipation, allergies, eyestrain, and nutritional deficiencies. The amazing benefits that ginkgo has on stress and fatigue is associated with its ability to lessen headache tension.

Helps With Anxiety and Depression: For those with nervousness, depression or mood swings, Ginkgo biloba extract can be helpful. Research suggests Ginkgo biloba benefits the body’s ability to handle stressors and counteracts the effects of high levels of stress hormones, like cortisol and adrenaline.

Ginkgo biloba is considered to be an adaptogenic herb that naturally raises the body’s ability to cope with stress. It can be especially helpful for people with generalized anxiety disorder (GAD) and possibly seasonal depression, panic attacks and social phobias.

Reduces Symptoms of Asthma: Studies have found Ginkgo biloba extract can reduce asthma-related symptoms. Because it lowers inflammation, improves antioxidant activity and positively effects nerve functioning, people have reported less trouble breathing when taking Ginkgo biloba.

Alleviates Symptoms of PMS: Early research has shown positive effects of taking Ginkgo biloba on reducing PMS symptoms, including mood swings, headaches, anxiety, fatigue and muscle pain. It also may have beneficial effects on mood and cognition in postmenopausal women and can help improve similar symptoms.

Helps Maintain Vision and Eye Health: Ginkgo biloba appears to be beneficial for eye health since it improves blood flow to the eyes and prevents free-radical damage that can affect the cornea, macula and retina. It can be especially beneficial for older adults in preserving vision and lowering UV damage or oxidative stress to eye tissue.

Improves Libido: Ginkgo biloba has positive effects on hormonal balance — particularly serotonin levels, blood pressure and circulation. This implies that it may help those dealing with erectile dysfunction and low libido. Ginkgo biloba has the potential to dilate blood vessels and improve blood flow to the genitals, which is important for reproductive health.

Helps Heal Hemorrhoids: Some studies have found that Ginkgo biloba helps those experiencing painful hemorrhoids, that cause swelling, pain and bleeding related to an increase in pressure on the veins of the anus and rectum. Ginkgo biloba may lower pain, improve pain tolerance and reduce inflammation, which may stop bleeding associated with hemorrhoids.


Provided below are abstracts from some recent meta-analysis studies that document the effectiveness of Ginkgo biloba on mental health.

Tan MS, Yu JT, Tan CC, Wang HF, Meng XF, Wang C, Jiang T, Zhu XC, Tan L

Efficacy and adverse effects of ginkgo biloba for cognitive impairment and dementia: a systematic review and meta-analysis.

In: J Alzheimers Dis. 2015;43(2):589-603. doi: 10.3233/JAD-14083

Research into Ginkgo biloba has been ongoing for many years, while the benefit and adverse effects of Ginkgo biloba extract EGb761 for cognitive impairment and dementia has been discussed controversially.
OBJECTIVE: To discuss new evidence on the clinical and adverse effects of standardized Ginkgo biloba extract EGb761 for cognitive impairment and dementia.
METHODS: MEDLINE, EMBASE, Cochrane, and other relevant databases were searched in March 2014 for eligible randomized controlled trials of Ginkgo biloba EGb761 therapy in patients with cognitive impairment and dementia.
RESULTS: Nine trials met our inclusion criteria. Trials were of 22-26 weeks duration and included 2,561 patients in total. In the meta-analysis, the weighted mean differences in change scores for cognition were in favor of EGb761 compared to placebo (-2.86, 95%CI -3.18; -2.54); the standardized mean differences in change scores for activities in daily living (ADLs) were also in favor of EGb761 compared to placebo (-0.36, 95%CI -0.44; -0.28); Peto OR showed a statistically significant difference from placebo for Clinicians’ Global Impression of Change (CGIC) scale (1.88, 95%CI 1.54; 2.29). All these benefits are mainly associated with EGb761 at a dose of 240 mg/day. For subgroup analysis in patients with neuropsychiatric symptoms, 240 mg/day EGb761 improved cognitive function, ADLs, CGIC, and also neuropsychiatric symptoms with statistical superiority than for the whole group. For the Alzheimer’s disease subgroup, the main outcomes were almost the same as the whole group of patients with no statistical superiority. Finally, safety data revealed no important safety concerns with EGb761.
CONCLUSIONS: EGb761 at 240 mg/day is able to stabilize or slow decline in cognition, function, behavior, and global change at 22-26 weeks in cognitive impairment and dementia, especially for patients with neuropsychiatric symptoms.

Amieva H1, Meillon C, Helmer C, Barberger-Gateau P, Dartigues JF.

Ginkgo biloba extract and long-term cognitive decline: a 20-year follow-up population-based study.

In: PLoS One. 2013;8(1):e52755. doi: 10.1371/journal.pone.0052755. Epub 2013 Jan 11

BACKGROUND: Numerous studies have looked at the potential benefits of various nootropic drugs such as Ginkgo biloba extract (EGb761®; Tanakan®) and piracetam (Nootropyl®) on age-related cognitive decline often leading to inconclusive results due to small sample sizes or insufficient follow-up duration. The present study assesses the association between intake of EGb761® and cognitive function of elderly adults over a 20-year period.
METHODS AND FINDINGS: The data were gathered from the prospective community-based cohort study ‘Paquid’. Within the study sample of 3612 non-demented participants aged 65 and over at baseline, three groups were compared: 589 subjects reporting use of EGb761® at at least one of the ten assessment visits, 149 subjects reporting use of piracetam at one of the assessment visits and 2874 subjects not reporting use of either EGb761® or piracetam. Decline on MMSE, verbal fluency and visual memory over the 20-year follow-up was analysed with a multivariate mixed linear effects model. A significant difference in MMSE decline over the 20-year follow-up was observed in the EGb761® and piracetam treatment groups compared to the ‘neither treatment’ group. These effects were in opposite directions: the EGb761® group declined less rapidly than the ‘neither treatment’ group, whereas the piracetam group declined more rapidly (β = -0.6). Regarding verbal fluency and visual memory, no difference was observed between the EGb761® group and the ‘neither treatment’ group (respectively, β = 0.21 and β = -0.03), whereas the piracetam group declined more rapidly (respectively, β = -1.40 and β = -0.44). When comparing the EGb761® and piracetam groups directly, a different decline was observed for the three tests (respectively β = -1.07, β = -1.61 and β = -0.41).
CONCLUSION: Cognitive decline in a non-demented elderly population was lower in subjects who reported using EGb761® than in those who did not. This effect may be a specific medication effect of EGb761®, since it was not observed for another nootropic medication, piracetam.

Zhang HF, Huang LB, Zhong YB, Zhou QH, Wang HL, Zheng GQ, Lin Y

[An Overview of Systematic Reviews of Ginkgo biloba Extracts for Mild Cognitive Impairment and Dementia.

In: Front Aging Neurosci. 2016 Dec 6;8:276. doi: 10.3389/fnagi.2016.00276. eCollection 2016

Ginkgo biloba extracts (GBEs) have been recommended to improve cognitive function and to prevent cognitive decline, but earlier evidence was inconclusive. Here, we evaluated all systematic reviews of GBEs for prevention of cognitive decline, and intervention of mild cognitive impairment (MCI) and dementia. Six databases from their inception to September 2015 were searched. Ten systematic reviews were identified, including reviews about Alzheimer’s disease (n = 3), about vascular dementia (n = 1), about both Alzheimer’s disease and vascular dementia (n = 2), about Alzheimer’s disease, vascular dementia and mixed dementia (n = 3), and a review about MCI (n = 1). Based on the overview quality assessment questionnaire, eight studies were scored with at least 5 points, while the other two scored 4 points and 3 points, respectively. Medication with GBEs showed improvement in cognition, neuropsychiatric symptoms, and daily activities, and the effect was dose-dependent. Efficacy was convincingly demonstrated only when high daily dose (240 mg) was applied. Compared with placebo, overall adverse events and serious adverse events were at the same level as placebo, with less adverse events in favor of GBE in the subgroup of Alzheimer’s disease patients, and fewer incidences in vertigo, tinnitus, angina pectoris, and headache. In conclusion, there is clear evidence to support the efficacy of GBEs for MCI and dementia, whereas the question on efficacy to prevent cognitive decline is still open. In addition, GBEs seem to be generally safe.

Hashiguchi M, Ohta Y, Shimizu M, Maruyama J, Mochizuki M.

[Meta-analysis of the efficacy and safety of Ginkgo biloba extract for the treatment of dementia.In: J Fr Ophtalmol (1988) 11(10):671-4 (Published in French)]

In: J Pharm Health Care Sci. 2015 Apr 10;1:14. doi: 10.1186/s40780-015-0014-7. eCollection 2015.

The benefit of Ginkgo biloba for the treatment of dementia remains controversial. The aim of this study was to evaluate the efficacy and safety of Ginkgo biloba in patients with dementia in whom administration effects were reported using meta-analysis.
METHODS: We searched MEDLINE, Embase, the Cochrane databases, and Ichushi for controlled trials of Ginkgo biloba for the treatment dementia. Clinical characteristics and outcomes were extracted. Meta-analysis results were expressed as standard mean differences (SMDs) in scores of the Syndrome Kurztest (SKT), Alzheimer’s Disease Assessment Scale Cognitive Subscale (ADAS-Cog) for cognition efficacy, or odds ratios (ORs) for dropouts and adverse drug reactions.
RESULTS: Thirteen studies using the extract EGb761 met our inclusion criteria, which were duration of 12 to 52 weeks and daily dose of more than 120 mg, and included a total of 2381 patients. Meta-analysis was performed by using 9 of 13 studies, 7 of which used the SKT and 2 ADAS-Cog (dose 120 mg, 26 weeks) scores as efficacy parameters. In meta-analysis of all patients, SMDs (95% confidence interval [CI]) in the change in SKT scores (7 studies) were in favor of Ginkgo biloba over placebo (SMD = -0.90 [-1.46, -0.34]), but 2 studies that used ADAS-Cog did not show a statistically significant difference from placebo for ADAS-Cog (-0.06 [-0.41, 0.30]). For Alzheimer’s disease (AD) and vascular dementia (VaD) subgroups, SMDs [95% CI] in SKT in the combined AD and VaD subgroup (-1.07 [-1.66, -0.47]) and AD subgroup (-1.36 [-2.27, -0.46]) were in favor of Ginkgo biloba over placebo. In terms of daily dose of Ginkgo biloba in the combined AD and VaD subgroup, SMD in SKT score in 240-mg daily dose groups was significantly greater than with placebo (-0.71 [-1.28, -0.14]). Dropout rates for any reason did not differ between two groups, but dropout rates due to side effects were significantly lower in Ginkgo biloba groups compared with placebo groups (OR = 1.72 [1.06, 2.80]).
CONCLUSIONS: Taking a 240-mg daily dose of Ginkgo biloba extract is effective and safe in the treatment of dementia.

For a more extensive list of Ginkgo Biloba abstracts go here.



Dr. Hank Liers, PhD leaky gut glyphosateFred Liers PhD leaky gut glyphosateWe recently added a category of products for Gut Health to the HPDI foundational supplements program. We did this not only because there is a documented increase in gut-related health issues, but also because we hear about gut health issues from our clients and resellers. They desire effective means for solving the gut health problems prevalent today.

One of the biggest gut health problems we see today is leaky gut syndrome. The syndrome goes by other names and encompasses various symptoms. These symptoms broadly encompass food allergies, sensitivities, and intolerances.

Yet, the symptoms can also include low energy, fatigue, immune disorders, as well as obesity and blood sugar issues. It also encompasses celiac disease and certain brain disorders.

In fact, most of these gut-related conditions and symptoms today go beyond what was historically meant by “leaky gut syndrome.” Today leaky gut and the conditions associated with it largely seem to relate to a combination of factors, including modern agricultural methods, use of antibiotics and certain other pharmaceuticals, and toxic chemicals in foods and the environment.

glyphosate herbicide spray

Studies show the herbicide glyphosate adversely impacts gut health.


Agriculture was not so long ago an organic affair. Chemical fertilizers were unknown, soils were healthier, and crops were at least non-GMO.

Things got worse with the introduction of chemical fertilizers, herbicides, and pesticides. The green revolution of the 1960s brought more changes, including the rise of monoculture crops and more dependence on chemicals.

Chemicals used in agriculture destroy soil microbes. These chemicals induce plant growth without simultaneously improving the quality of the soil. Consequently, the result is depletion of nutrients in soils. This has been proven by measurable declines in vitamins, minerals, and other nutrients in food crops.

When soils are continuously depleted and are nutrients are not replaced or augmented (as in Biodynamic agriculture, for example), soils have fewer nutrients. Eventually crops grown in these soils will be nutrient-poor and therefore not optimal for health. Nutrient declines in soils are significant, and soils continue to be depleted of nutrients.

The combination of chemical fertilizers, herbicides, and pesticides has created an unsustainable system of agriculture that does not produce nutritious food crops. Herbicides such as 2,4-D and atrazine, and pesticides like DDT (which remains in soils) are examples of chemicals that can significantly harm human and environmental health.

The introduction of genetically modified (GMO) crops has accelerated the negative effects of industrialized farming methods. This is especially true in terms of the lowering soil-quality and adversely impacting soil microbes, reducing nutrient levels in crops, and both directly and indirectly harming human health.

GMO crops have not been properly tested for safety. The dangers of GMO crops are significant. Bt corn is a crop whose genetic modification is associated directly with gut health issues (see charts below). Bt corn was created to damage the intestines of insects, but that also damages the health of the human gut.

When combined with specialized herbicides designed for use on GMO crops, the dangers of GMOs increase significantly. The primary herbicide used for GMO crops is glyphosate, which is a mineral chelator, endocrine disruptor, and biocide with antibiotic effects that kill bacteria (beneficial and harmful) indiscriminately leading to an imbalanced human microbiome.

Glyphosate appears to be associated with an increasing number of adverse health conditions partly because many health problems can be caused or exacerbated by nutrient deficiencies, endocrine disruption, microbiome imbalances, and other toxic effects. These health conditions include leaky gut syndrome which not only may result from an imbalanced microbiome, but also from a loosening of the necessarily tight junctions in the gut wall that protect us from exposure to foreign proteins not unlike the blood-brain barrier protects our brain.


Use of the herbicide glyphosate has increased dramatically in recent years. Glyphosate is the primary (but by no means the only) ingredient in the herbicide RoundUp.

Glyphosate kills plants including weeds, and it does this partly by acting as a mineral chelator that prevents the uptake of nutrients by plants. This starves the plant until it dies. However, plants genetically modified to withstand glyphosate still contain fewer nutrients and are therefore less nutritious.

Moreover, any glyphosate you consume acts as a chelator in your body that  blocks your uptake of minerals and nutrients. This will not be good, especially if the GMO foods you consume are already nutrient deficient. Glyphosate also interferes with how you uptake and process nutrients (like manganese) in ways that guarantee depletion in the body, as will be discussed further below).

gmo crops glyphosate

Source: N. L. Swanson, “Genetically Modified Organisms and the Deterioration of Health in the United States” (2013)

A major reason for increasingly larger applications of glyphosate on crops is the rise of glyphosate-resistant “super weeds.” This was not predicted to happen, but clearly it is happening. Thus, the “solution” to the development of super weeds has been simply to apply more glyphosate. This means greater amounts of poison in crops, and of course, greater profits for the herbicide company.

The problem is that glyphosate is extremely toxic. If there were a perfect storm scenario for herbicide use, then glyphosate would be one component of it. Many scientists are concerned about it, including former genetic engineers like Thierry Vrain, who now advocates growing and consuming organic foods (see more below).

Increased use of glyphosate will in turn accelerate the rise of super-resistant weeds, and accelerate damage to the health of those who consume it.

Not to mention the unknown health risks of the genetically modified (GMO) crops themselves, which are sprayed with glyphosate. How would you be able to tell which is more damaging to health, the toxins embedded in GMO crops or the sprays that soak both GMO and non-GMO crops alike. None have been properly tested, or test results are hidden or suppressed.

Beyond all this, non-GMO crops like wheat, oats, barley, beans, and nuts are routinely sprayed with glyphosate at the end of the season as a means to dry these crops to make harvesting easier. So much for trying to eat verified non-GMO.

You’re likely getting a lot of glyphosate in your diet…unless you eat 100% organically grown foods that are not contaminated with glyphosate by direct spraying, spraying for the purposes of drying, or from drift related to nearby spraying.

And with increased levels of spraying to apply more of this herbicide, the likelihood is you’re getting glyphosate not only from foods, but also from a contaminated water supply (wells, rivers, streams), and from rainfall (with more than 65% of rain samples testing positive).


A noteworthy article on the topic of glyphosate and genetically modified organisms (GMO) is N.L.  Swanson’s “Genetically Modified Organisms and the Deterioration of Health in the United States” (2013). This was originally published as a series of articles on the Seattle Examiner website.

Scientists may disagree on the level of veracity of the article, and quibble over the finer points of statistical correlation. Meanwhile, people are getting sicker, not healthier. And that is the point.

If indeed glyphosate is impacting human health adversely at even a fraction of the levels argued by Swanson, then individuals should reduce their consumption of GMO foods as much as possible to avoid health consequences.

Foods containing GMOs should be clearly labeled, like they are in many other countries. Consumers have a right to know if foods contain GMO. There is no valid objection to labeling since many other (and far less harmful) ingredients in foods are labeled. This is a transparency issue. It is the least consumers deserve.

In July 2016, the US enacted the so-called DARK Act, which requires labels for GMO products. However, this law is far weaker than the Vermont law that preceded it. The US law preempts state laws. It represents a poor attempt to address consumers’ desire for labeling of GMO foods. It offers no standard labeling requirements, nor any means to enforce compliance for companies that fail to label. And while some may consider the US law progress for consumers, consider that in Europe GMO labeling went into effect back in 1997 – nearly 20 years ago.

In addition, proper scientific testing of the health effects of GMOs and in particular the herbicide glyphosate, as well as the adjuvants and surfactants contained in glyphosate-containing products—and how these ingredients act synergistically—must be carried out. Consumers should never be guinea pigs when science is available that can protect them and help them make informed decisions.

Not unlike tobacco companies that suppressed and downplayed the harm of their products, today’s purveyors of agricultural chemicals (and especially GMOs and glyphosate) are not particularly concerned about the adverse health effects of their products. In fact, it appears to be just the opposite, as studies indicating harmful effects frequently have been suppressed.

Several of the studies used to indicate safety of GMOs were short-term studies (three months) conducted by companies who make and sell the products themselves without peer review or release of data. Whereas longer-term, independent studies indicate probable harm to health, therefore showing the precautionary principle was disregarded in approving GMOs for human consumption.

In order for consumer to protect themselves, GMO labeling is a minimum measure. Most nations already require clear labeling or ban GMOs.


The use of antibiotics in livestock results in a tainted food supply. This means that foods ingested contain antibiotics that damage and destroy beneficial microbes in the human gut. This contributes to reduced microbiome diversity and paves the way for a takeover by harmful bacteria.

Then there is the overuse of antibiotics in human medicine. The use of antibiotics significantly damages microbiome health and diversity. The importance of the microbiome for human health is such that antibiotic use that kills beneficial bacteria and imbalances the gut flora is proven to reduce overall health and can contribute to major health problems throughout life. This is especially true when antibiotics are used in childhood when the microbiome is establishing itself.

Glyphosate is not considered an antibiotic per se, but it exerts antibiotic-like effects. That is, glyphosate destroys microbes by acting on the Shikimate pathway, and therefore acts like an antibiotic. This pathway is not present in human beings, but is present in plants and most microbes important for the health of the human gut.

Glyphosate interferes with the synthesis by gut bacteria of aromatic amino acids (including tyrosine and tryptophan) as well as methionine. This leads to shortages in critical neurotransmitters such as serotonin and melatonin as well as folate.

There is evidence to show that glyphosate produces resistance to antibiotic drugs, just as overuse of antibiotics themselves contributes to the increase of so-called “superbugs,” or bacteria resistant to most or all antibiotics. This fact is another reason glyphosate contributes to the health problems relating to antibiotic use and to gut health issues, in particular.

The overuse of antibiotics both in humans and animals is an ongoing problem with many authorities calling for a reduction in use so that antibiotics are not rendered useless by the development of antibiotic-resistant strains of bacteria.

Current policies regarding antibiotics virtually guarantee that not only will microbiome health be harmed by the consumption of antibiotic tainted foods and by the use of antibiotics too easily prescribed, but also that harmful bacteria will become stronger rendering antibiotics less useful in applications where they are truly needed.

An interesting fact in this regard is that Pseudomonas aeruginosa, a gram-negative bacteria, is a major problem in hospitals today due to its resistance to multiple antibiotics. It is one of only three bacterial species that can break down glyphosate. However, it produces formaldehyde as a by-product. Formaldehyde is a well-established neurotoxin. It is likely that the growth of this harmful bacteria is stimulated by the presence of glyphosate in the gut.

Avoidance of antibiotics in foods and when not medically necessary are ways individuals can help keep themselves healthy.


While this article deals primarily with the topic of gut or gastrointestinal health, it is noteworthy that glyphosate is considered to be an endocrine disruptor.

Endocrine disruption is associated with birth defects, reproductive problems (like infertility), breast cancer, and developmental problems in babies and children before and after birth, as well as a host of other health effects.

Endocrine disruptors are common in the environment, and we have written about them in previous posts. Glyphosate’s role as an endocrine disruptor is important not only because it is another harmful element among its many dangers, but also simply because of its ubiquitousness in the environment.

The amount of glyphosate spray in the US and the world in extraordinary. As weeds have become resistant to glyphosate (leading  to the rise of super weeds), the solution has been to spray more of it. Therefore, the amounts to which individuals are exposed have skyrocketed along with the increase in its application on crops and elsewhere.

Also, as noted, the practice of spraying glyphosate as a desiccating agent on non-GMO crops (such as wheat, oats, sugar cane, and peanuts) contributes significantly to human exposure. So too does “household” use in gardens and use by municipalities for spraying to decrease “weeds” in public places, such as parks and schools.


Dr. Stephanie Seneff is a leading researcher in the area of the harmful effects of glyphosate. The following YouTube presentation by Dr. Seneff and Dr. Sachin Patel (interviewer) provides a wealth of information for the reader and is highly recommended: https://www.youtube.com/watch?v=TpoGUPwe40c

In Dr. Seneff’s presentations she has pointed out that the following nutrients, hormones, and neurotransmitters are disrupted by glyphosate:

  1. Folate, Vitamin K, Vitamin A, Vitamin D, and cobalamin (Vitamin B12).
  2. Aromatic amino acids and methionine
  3. Iron, manganese, cobalt, selenium, zinc, and sulfur
  4. Serotonin, melatonin, dopamine, epinephrine
  5. Melanin (skin tanning agent), thyroid hormone
  6. NAD, glutathione (key antioxidant defenses)

Clearly it would be wise to take in foods and nutritional supplements that could replete the body with these  substances.

In order to compensate for these effects of glyphosate Dr. Seneff recommends the following supplements:

  1. Curcumin (see HPDI CURCUMIN C3 COMPLEX)
  2. Garlic
  3. Vitamin C (see HPDI PRO-C™ and Ultimate Protector™)
  4. Probiotics (see Prescript-Assist™)
  5. L-5-Methytetrahydrofolate (see HPDI 5-MTHF)
  6. Vitamin B-12 (see HPDI Methylcobalamin)
  7. Glutathione (contained in HPDI GLU-NAC Plus)
  8. Taurine (contained in HPDI Hepa Plus)


Recently, Dr. Seneff and collaborators have identified the fact that glyphosate – a glycine amino acid based molecule – can disrupt a large number of enzymes in the body by inserting itself into proteins during the synthesis process where glycine would normally be inserted. When this happens, the function of the enzyme is completely negated. For further details see: https://www.youtube.com/watch?v=snNRfAfSeUk


Another class of worrisome genetically modified crops are Bt corn and other Bt crops (cotton, potato, and soy). Note that there are also glyphosate tolerant/resistant strains of corn (maize), so all types of GMO corn are potentially hazardous to health.

Bt corn is a variant of maize genetically altered to express proteins from the bacterium Bacillus thuringiensis. Thousands of different Bt strains exist that produce proteins toxic to insect pests. Particular strains are chosen to target specific plant pests, such at the European Corn Borer (ECB).

 When an insect consumes Bt-containing plant tissues, one or more Bt proteins become activated in its gut, creating toxins that paralyze its digestive system and form holes in its gut wall.

Bt toxins bind to receptors in the insect’s gut. This causes the  gut wall to break down and allows toxins, as well as normal gut bacteria to enter the insect’s body. Toxins and bacteria proliferate in the insect’s body causing death. Notably, many insects have developed resistance to glyphosate, just as have weeds.

It has been noted by commentators that the human digestive system appears to be damaged in a similar way by proteins in Bt corn. In any event, as the number of acres planted with Bt corn increases, it appears that human digestive disorders also increase.

irritable bowel syndrome gut health bt corn

Source: N. L. Swanson, “Genetically Modified Organisms and the Deterioration of Health in the United States” (2013)

Disorders of the digestive system associated with Bt toxins not only include irritable bowel syndrome (IBS) and constipation, but also Crohn’s Disease and Ulcerative Colitis.

inflammatory bowel disease crohn colitis gut bt corn

Source: N. L. Swanson, “Genetically Modified Organisms and the Deterioration of Health in the United States” (2013)

While the effects of the Bt toxin are different than those of glyphosate and other chemicals in glyphosate-containing crop chemicals, the fact is that evidence shows that the Bt toxins appear to adversely impact gut health.


Among key takeaways from examining the literature of problems associated with antibiotic use, as well as with the chemicals associated with modern agriculture and genetically modified foods (i.e., glyphosate and other herbicides, pesticides, and various surfactants and adjuvants used with them): Choose to eat organic foods as much as possible for best health.

Only by consuming organic foods can individually significantly reduce the amount of glyphosate, pesticides, antibiotics, and other harmful chemicals in the diet to support good health in general, and gut health in particular. Organic foods are also more nutrient dense, and therefore more nutritious.

After it is understood how current industrial agricultural methods contribute to damaging human health, then organic foods can be seen as a solution helping ensure avoidance of most or many of harmful elements in foods.

Organically grown foods may be tainted by drift or by toxins in the soil existing before the adoption of organic farming methods. Yet, the amounts of such toxins will be significantly reduced overall by consuming organic foods. The longer-term solution is adoption of organic methods (and corresponding reductions in use of chemicals and GMOs in agriculture) that will result in a cleaner, safer food supply for all.

Some say that organic foods are no better, or cost too much, or do not improve health. But the truth is that they are better, should not cost more, and are far more sustainable for human and planetary health. In fact, at this point in time, consuming organic foods may be the only practical solution for avoiding health problems, especially gut-health problems, associated with industrialized, chemically based agricultural methods.

Growing food yourself is another option, as is purchasing organic or locally grown organically grown produce at your Farmer’s Market. These foods will not be sprayed with toxins and will not suffer the same level of nutrient declines found in conventional produce. Having even a relatively small garden at home will allow you to supplement organic foods you obtain locally. Some neighborhoods support community gardens where you can grow foods organically.

Between consuming foods you grow, purchasing organic or non-sprayed produce locally and/or at natural foods stores, emphasizing grass-fed, free-range animal products (e.g., eggs and meats), and reducing meals at restaurants that serve conventional foods (as well as ordering organic and non-GMO foods whenever possible), you can largely bypass or reduce the toxicity and gut-health issues associated with the toxins and GMOs in foods sold in grocery stores and ubiquitous in our food distribution system.

A 100% organic diet is recommend, entirely possible, and at the very least a worthy goal. It will pay dividends in terms of good health and how you feel.

Others recommend to detoxify from glyphosate by consuming an organic diet.


Wheat stands out as a singular food to avoid. It been hybridized beyond all recognition with many genes being added because wheat genes are additive. The wheat protein gluten has been linked to many types of health problems.

Gluten has long been a problem for gut health. Now with glyphosate being sprayed directly on wheat crops (as well as oats, sugar cane, and peanuts) as a desiccating agent, it seems that opening tight junctions in the gut and then having exposure to gluten is a prescription for disaster.

glyphosate wheat leaky gut intestinal infection

Glyphosate increasingly is sprayed on wheat (a non-GMO crop) for drying before harvest. How does poisoning wheat this way make sense?

Some commentators (like Wheat Belly author William Davis, MD) show that gluten is linked with obesity, diabetes, celiac disease, and many others.

Avoidance of wheat, gluten, and other simple carbohydrates is a good idea if you would maintain and retain good gut health.

celiac glyphosate wheat goo

Celiac disease has significantly increased with the practice of spraying glyphosate on wheat.


In the article “Glyphosate’s Suppression of Cytochrome P450 Enzymes and Amino Acid Biosynthesis by the Gut Microbiome: Pathways to Modern Diseases,” Stephanie Seneff and Anthony Samsel state that there are many pathologies to which glyphosate may contribute:

“The pathologies to which glyphosate could plausibly contribute, through its known biosemiotic effects, include inflammatory bowel disease, obesity, depression, ADHD, autism, Alzheimer’s disease, Parkinson’s disease, ALS, multiple sclerosis, cancer, cachexia, infertility, and developmental malformations.” (Entropy 201315(4), 1416-1463; doi:10.3390/e15041416)


Industrial agriculture, including the practices associated with the cultivation of GMO crops, harms the soils and human health.

Dangers to human health from industrial agriculture and GMOs includes harm to gastrointestinal health. This encompasses many conditions, including Leaky Gut Syndrome.

Leaky gut does not always result from a single cause, but can involve multiple factors, including exposure to glyphosate (and its adjuvants), Bt toxins, depleted nutrient levels, wheat and wheat protein (gluten/gliadin) exposure, microbiome imbalances or disruption, antibiotic use or consuming foods containing antibiotics, other chemical exposures, and additional factors.

Ways to avoid leaky gut: 1) Consume a 100% organic diet, 2) Avoid GMOs, 3) Avoid antibiotics, 4) Maintain a healthy microbiome, 5) Avoid wheat and simple carbohydrates (and simple sugars), 6) Improve nutrient levels through diet and dietary supplements, 7) Use specific supplements that help restore and maintain gut health 7) Detoxify on a regular basis using juices, herbs, and other practices.

We will continue writing articles for blog series on the topic of gut health. In coming months, we will write about various means for improving gastrointestinal structure and function. These means include restoring tight junctions in the gut using Restore (lignite formula).



Center For Food Safety (CFS)

Institute for Responsible Technology (IRT)

The Detox Project (Glyphosate Portal)


Glyphosate-based herbicides are toxic and endocrine disruptors in human cell lines

Genetically Modified Organisms and the Deterioration of Health in the United States“, N. L. Swanson, MIT

Glyphosate’s Suppression of Cytochrome P450 Enzymes and Amino Acid Biosynthesis by the Gut Microbiome: Pathways to Modern Diseases

Plants have a microbiome just like humans — and it could transform how our food is produced

Understanding Glyphosate Toxicity: Interview with Genetic Engineer Thierry Vrain (Mother Earth News)


Gut Health – Intestinal Rejuvenation Formula

Amending the HPDI Foundational Supplement Program

Microbiome, Diet, and Prescript-Assist Probiotic and Prebiotic

Kidney Cleansing with Juices & Herbs

Liver Cleanse with Juices & Herbs

Rejuvenation Program: Part 2 (Detoxification)

Death by One (Or Two) Thousand Cuts

Dr. Mark Sircus’s blog article at www.DrSircus.com:
“Apples – Pectin – Intestinal Formula”


Brain Maker: The Power of Gut Microbes to Heal and Protect Your Brain for Life by Dr. David Perlmutter

Grain Brain: The Surprising Truth About Wheat, Carbs, and Sugar – Your Brain’s Silent Killers by Dr. David Perlmutter

Wheat Belly: Lose the Wheat, Lose the Weight, and Find Your Path Back to Health by Dr. William Davis




PRESCRIPT-ASSIST™ Probiotic Formula (soil-based organisms)

RESTORE For Gut Health (lignite formula)

(proteolytic enzymes)

(full spectrum plant enzymes)

Nascent Iodine

Magnesium Oil, Flakes, Gel



Fred Liers PhD intestinal rejuvenation formula gut healthIntestinal and digestive tract health are critical for health. “All disease begins in the bowel” is a mantra for herbalists and natural healers. Healthy gut structure and function is important for digestion of food, assimilation of nutrients, elimination of wastes, detoxification, and even brain function and mental health due to reciprocal relations along the gut-brain axis.

Intestinal Rejuvenation Formula gut health

HPDI offers several products formulated for optimal gut health. That is, nutritional supplements intended to improve intestinal and digestive system health and function. These formulas include probiotics like Prescript-Assist™ (soil-based organisms), Restore For Gut Health (lignite formula), digestive enzymes, and Intestinal Rejuvenation Formula.

When used as part of an overall program of gut health and especially when combined with an excellent, whole-foods diet, these gut-health formulas help optimize intestinal health in a world fraught with environmental factors and lifestyle elements that can destroy GI tract health. I will talk about some of these products in this article. However, my main focus will be upon Intestinal Rejuvenation Formula.


Intestinal Rejuvenation Formula (IRF) is a high-fiber powdered supplement designed to act as a sweep to cleanse and help detoxify the entire gastrointestinal (GI) tract. Dr. Hank Liers formulated it as an effective drawing, detoxifying, and healing formula for the bowel. Within the HPDI supplement system, the formula is considered a specific-condition formula for gut health. That is, it is not a foundational supplement or an enhancement formula.

intestinal rejuvenation formula

Dr. Hank Liers’ Intestinal Rejuvenation Formula cleanses, detoxifies, purifies, and heals.

Detoxification is one of the main components of the HPDI Rejuvenation Program. As such, the capacity of Intestinal Rejuvenation Formula to detoxify the bowel makes it an integral supplement in the program.

Intestinal Rejuvenation Formula is a gentle-acting formula that may be taken daily or as needed. It is easily integrated into a gut health routine or regimen. Regular use is warranted for individuals desiring to maintain gut health. It is also beneficial for periodic use, such as seasonal cleansing, reduced bowel function, or constipation. Yet, it offers many benefits for chronic issues such as bowel pockets, diverticulosis, and diverticulitis. Acute uses include applications for upset stomach, food poisoning, diarrhea, as well as topical use for insect or snake bites.

Intestinal Rejuvenation Formula contains ingredients that help it to cleanse by sweeping wastes and deposits from the GI tract (psyllium, pectin, bentonite), coat and soothe (slippery elm bark and marshmallow root), sequester toxins (fibers and activated charcoal), heal and rebuild the mucosa (vitamin C and CGF).


We live in an age where many environmental factors and lifestyle elements contribute to GI tract dysfunction. These include overuse of antibiotics and use of antibiotics in foods that destroy microbiome diversity. These elements also encompass agricultural toxins (e.g., glyphosate from RoundUp) used in growing GMO (genetically modified organisms) crops consumed in foods that contribute to weakening of tight junctions in the GI tract.

As such, it is imperative individuals take steps to restore proper function and rebuild gut health. Such steps may include consuming organic and non-GMO foods that neither contain herbicides like glyphosate nor GMOs.

In addition, overconsumption of wheat, simple carbohydrates, and sugars is a major element contributing to a pandemic of gut dysfunction. It is well known that wheat and other food crops containing gluten, gliadin, and related proteins readily contribute to GI tract problems among an ever increasing percentage of the population.

Books like William Davis’ Wheat Belly: Lose the Wheat, Lose the Weight, and Find Your Path Back to Health, and David Perlmutter’s Grain Brain: The Surprising Truth About Wheat, Carbs, and Sugar – Your Brain’s Silent Killers and Brain Maker: The Power of Gut Microbes to Heal and Protect Your Brain for Life, document the adverse effects caused by the consumption of wheat and refined carbohydrates on health, especially gut and brain health.

Wheat in particular is singled out due to its extensive hybridization, which has created a very different genetic profile for the grain (despite the fact that it has not yet been genetically modified on a large scale). This has created high-yielding wheat variants that can cause or contribute to adverse health effects, and have not been subject to safety testing.

Yet, it is known that glyphosate herbicide is routinely sprayed on non-GMO crops—like wheat, oats, and beans—as a drying agent to speed harvesting. Consuming non-GMO foods may not be sufficient to prevent ingestion of toxic glyphosate and therefore avoid its adverse GI tract effects. Consumers are best served by consuming certified organic, biodynamic, chemical-free, and/or home grown foods.

The increase in gut health issues among the population is reflected both in the dramatic rise of diabetes, celiac disease, obesity, and brain maladies (like Alzheimer’s and Parkinson’s Disease) in recent years.

The authors suggest that elimination or significant reductions in the consumption of wheat, sugar, and refined carbohydrates will go far in helping to improve and restore health. And that starts in the gut.

In addition to dietary changes and lifestyle modifications, a balanced fiber and gut-soothing formula like Intestinal Rejuvenation Formula can be part of a complete program to cleanse, heal, and rebuild the gut for improved GI tract function.

A complete program for gut health includes probiotics, which are the subject of various articles we have written that include recommendations for consuming dietary probiotics and probiotics, creating a probiotic-friendly lifestyle, as well as supplementing with probiotic formulas like Prescript-Assist.

Intestinal Rejuvenation Formula contributes to gut health differently than dietary or supplemental probiotics, yet is designed to work well with probiotics of all types to improve gut health. HPDI recommends a synergistic approach to gut health encompassing diverse approaches (and multiple products) combined to produce optimal results.


Intestinal Rejuvenation Formula cleanses the entire digestive tract by drawing toxins, clearing blockages, and supporting natural movement. It works by coating and adhering to the lining of the intestines. This unique action allows it to absorb fecal plaques and other debris, soften unhealthy deposits, and sweep them away for elimination in the stool.

Intestinal Rejuvenation Formula neutralizes and removes hundreds of toxins, including heavy metals (e.g., mercury and lead). It draws out many times its weight in material encrusted or trapped in the intestinal lining. It also provides nutrients known to nourish the GI tract, and that promote normal elimination functions.


Intestinal Rejuvenation Formula relieves symptoms of constipation, including gas, bloating, cramps, indigestion, and nausea caused by excessive waste in the bowel. It also soothes the intestinal lining and colon wall, and promotes a well-functioning colon. This means it can contribute to greater health not only through removal of toxins and intestinal blockages, but also by allowing greater absorption of nutrients from food (i.e., after the intestines are cleansed). It also can contribute to achieving normal weight by promoting elimination of old fecal matter (e.g., post-putrefactive deposits), and by helping to establish and maintain normal bowel function.


Intestinal Rejuvenation Formula acts as a wonderful soothing agent for the mucous membrane linings of the entire intestinal tract, especially the colon. This makes it an important formula for individuals experiencing irritable bowel syndrome, spastic colon, colitis, Crohn’s disease, diverticulitis, or any digestive tract condition causing hot, burning, irritated, or bleeding bowels and/or diarrhea. This unique healing formula is also an excellent remedy for food poisoning, because it can absorb harmful bacteria and toxins.


Due to its excellent detoxification and intestinal cleansing properties, Intestinal Rejuvenation Formula is ideal for use in periodic cleansing regimens, such as bowel cleansing, liver cleansing, kidney cleansing, or many types of juice cleanses, fasts, or flushes.

When using Intestinal Rejuvenation Formula as part of a short-term cleansing regimen (3–30 days), it can be used at higher levels, such as up to 1 tablespoon 3–5 times daily, as needed.

Note: After a cleansing regimen, it is useful to repopulate the gut with beneficial bacteria using a high-quality probiotic formula such as Prescript-Assist™ (soil-based organisms).


Another benefit of Intestinal Rejuvenation Formula is its ability to stop loose stools and diarrhea. This is especially important in cases of acute diarrhea in which dehydration and inability to assimilate nutrients from foods creates a problem for health.

As noted, Intestinal Rejuvenation Formula helps regulate bowel function. It therefore can help constipated individuals become more regular. However, in cases of diarrhea, it can fill the GI tract with sufficient bulk (fiber) to slow the rate of excretion, as well as help prevent dehydration due to fluid loss.

Because of the safety and efficacy of Intestinal Rejuvenation Formula, it is also safe for use with children and pets. Be sure to give with sufficient water and scale down the dose appropriately depending on the size of a child or pet.


Intestinal Rejuvenation Formula contains psyllium husk powder (organic), cold-milled flax seed powder (organic), apple pectin, bentonite clay (wildcrafted), marshmallow root powder (organic), slippery elm bark powder (organic), activated willow charcoal (wildcrafted), inulin / fructooligosaccharides (from chicory root), ginger root powder (organic), natural lemon flavoring, Vitamin C (from magnesium ascorbate), malic acid, grape extract (pulp, skin, and seed), licorice root powder (organic), stevia leaf extract (97% rebaudioside A), magnesium (from magnesium ascorbate), and chlorella growth factor (CGF).

INGREDIENTS: One teaspoon (3.23 gram) provides the following nutrients:

Psyllium Husk Powder (organic) – 1,000 mg
Apple Pectin – 400 mg
Bentonite Clay (wildcrafted) – 400 mg
Cold-Milled Flax Seed Powder (organic) – 400 mg
Marshmallow Root Powder (organic) – 200 mg
Slippery Elm Bark Powder (organic) – 200 mg
Activated Willow Charcoal (wildcrafted) – 100 mg
Spirulina Pacifica – 100 mg
Inulin / Fructooligosaccharides (from Chicory Root) – 100 mg
Ginger Root Powder (organic) – 100 mg

Natural Lemon Flavor – 100 mg
Vitamin C (from magnesium ascorbate) – 60 mg
Malic Acid – 50 mg
Grape Extract (pulp, skin, & seeds) – 40 mg
Licorice Root Powder (organic) – 40 mg
Stevia Leaf Extract (97% Rebaudioside A) – 13 mg
Magnesium (from magnesium ascorbate) – 4.5 mg
Chlorella Growth Factor (CGF) – 4 mg

The nutrients contained in Intestinal Rejuvenation Formula are all known to provide unique therapeutic benefits and healing properties. Consequently, the formula is carefully designed so the ingredients work together synergistically to leverage and maximize the capacities of each one. This results in a formula that is superior in action and that can far more effectively support health and healing in the intestinal tract than single ingredients or shotgun approaches (that often result in reduced effectiveness through the use of fillers, imbalanced formulation, or less than the highest quality ingredients).

Intestinal Rejuvenation Formula is a superior formulation representing a higher level of design expertise. This unique formula can offer significant benefits and results for individuals who wish to improve, regenerate, rejuvenate, heal, and sustain excellent gastrointestinal health.

gut health intestinal rejuvenation formula

Ginger is an ingredient known to support gut health.


Psyllium seed husks are soluble in water, expanding and becoming mucilaginous when moistened. Psyllium seed husks are indigestible in human beings and are used as a source of dietary fiber. They are used to relieve constipation, irritable bowel syndrome, diverticular disease, and diarrhea. They are also used as a regular dietary supplement to improve and maintain regular gastrointestinal (GI) transit.

The inert bulk of psyllium husks helps to provide a constant volume of solid material regardless of other aspects of the diet or any disease condition of the gut. Recent research also shows psyllium seed husks to be promising in lowering cholesterol and controlling diabetes.


As a dietary fiber, apple pectin is helpful in maintaining good digestive health. Pectin forms a colloidal solution in water and gels when cool. An indigestible, soluble fiber, apple pectin is a general intestinal regulator used in many healing preparations, especially as an anti-diarrheal agent. Researchers at the University of California, Davis (UCD), found that apple pectin acts as an antioxidant against the damaging portion of cholesterol in the blood stream.

It has been established that a diet rich in apple pectin may help protect against certain diseases. Research in Japan shows that apple pectin can act as a chemopreventive agent. Apple pectin helps maintain intestinal balance by cleansing the intestinal tract with its soluble and insoluble fibers.

Apple pectin tends to increase acidity in the large intestines and is advocated for those suffering from ulcer or colitis and for regulating blood pressure. Pectin is also effective in causing regressions in and preventing gallstones. There is also evidence that the regular use of apple pectin may lessen the severity of diabetes.

Apple pectin is known to draw radiation from the body. Russian doctors have found apple pectin to be among the most effective means for protecting against radiation when consuming contaminated foods is unavoidable. Pectin, along with vitamins and minerals, eliminates radionuclides ingested from foods. This is especially relevant given recent meltdowns and radiation releases from the nuclear complex in Fukushima, Japan. Radiation from this catastrophe has contaminated (and continues contaminating) food crops across the entire northern hemisphere (and beyond), especially crops grown in North America.


Bentonite clay has a large and varied mineral content, including over 50 minerals. Seen under a high powered microscope, bentonite is composed of extremely minute rectangular particles. The wide surfaces are negatively charged and the edges are positively charged. Therefore, its adsorptive power is many thousand times more negative than positive. It has a negative electrical attraction for positively charged particles. In the human body, various toxic poisons are positively charged. The very minuteness of the particles give it a large surface area (about 1,000 square meters per gram) relative to its volume, thereby enabling it to pick up many times its own weight (as high as 40 times) in positively charged particles.

When bentonite clay absorbs water and swells, it stretches open like a highly porous sponge. Toxins (including pathogenic viruses, herbicides, and pesticides) are drawn into these spaces and bound through electrical attraction. The bentonite is eventually eliminated from the body with the toxins bound to its multiple surfaces. Diarrhea can be remedied through the use of bentonite clay because of its capacity to bind stools. Bentonite clay can act immediately to bind irritants in the gastrointestinal tract.

COLD-MILLED FLAX SEEDS (organically grown)

Flax seeds (Linum usitatissimum L.) contain essential fatty acids (an excellent vegetarian source of omega-3 alpha-linolenic acid), protein, soluble fiber, insoluble fiber, antioxidant lignans, minerals, and vitamins. Lignans are a phytoestrogens considered to be antioxidants. Flax seeds contain among the highest levels of lignans among all plant foods.

The unique properties of Heartland’s RCM™ Flax (Real Cold Milled) organic flaxseed provides enormous advantages over whole flax seeds, ground flax powders, and other milled flax seed products. In particular, cold-milled flax seeds offer readily assimilable omega-3 and omega-6 fatty acids because of special no-heat processing that protects these delicate oils and makes them available for uptake into the body.

RCM™ Flax cold-milled flaxseed is processed using a unique, proprietary method that preserves the delicate oils and allows for optimal uptake of the oils and other nutrients (e.g., soluble fiber) into the body. That is, flax seeds must be milled into a flour or meal to obtain maximum benefits from its oils and dietary fiber. However, typical methods of grinding or pounding flaxseeds separate the oil from the seeds (and heat the oils), thereby causing the oils to oxidize and become rancid.

In contrast, cold milling is a unique process that does not involve heating delicate oils and keeps them protected within finely milled pieces of seed. Thus, cold-milled flax seed is not significantly oxidized and remains fresh for an extended period of time. Conversely, when flax seeds are harshly ground or crushed, the oils do not remain fresh because there is no inherent protection from oxidation. Cold milling allows the seed to retain and protect its oils because the process does not release the oils from the seeds .

RCM™ Flax offers a non-refrigerated shelf life of greater than 24 months. A study conducted at North Dakota State University confirms that peroxide levels of RCM™ Flax remain exceptionally low for an extended periods. While this flaxseed retains its freshness for an extended period, when refrigerated (or consumed within several months), it provides amazingly high levels of freshness.

The organic cold-milled flax seeds in Intestinal Rejuvenation Formula contain oil amounts varying between 38–45%, with the oil offering a high percentage (47–53%) of the omega-3 alpha-linolenic acid (ALA) and 15-18% omega-6 linoleic acid. Alpha-linolenic acid (ALA) is an essential fatty acid acting in the human body as a substratum for the transformation into EPA and DHA through the action of desaturation and elongation enzymes. The seeds also contain some omega-6 essential fatty acids and exhibit a favorable omega-3 to omega-6 ratio of 3:1. Modern diets contain too few omega-3 fatty acids.

Cold-milled flax seeds possess 15–30% protein (typically 20%) and the amino acids of flax protein have no limiting factors in the adult diet (i.e., they are a complete protein source having all of the essential amino acids in an appropriate balance). Flax seeds are also a source of magnesium, calcium, potassium, phosphorus, zinc, and copper. They also have demonstrated antioxidant activity.

The most important antioxidants flax seeds provide are phytoestrogens known as lignans. Because cold milling flax seeds significantly reduces oxidation, this exceptional flax seed has great potential within the food industry when compared to other alpha-linolenic acid sources, such as typical ground flaxseed powders, which can exhibit rapid decomposition due to a lack of antioxidant protection from oxidation.

The human body easily digests flax seeds. The seed’s outer layer is rich in mucilloid soluble fiber (flax seed possesses 10-15% soluble fiber) and absorbs at least 4 times its weight in water. When mixed with water or stomach juices, the seeds form a gel that creates a physical barrier between the carbohydrates and the digestive enzymes that break them down. The carbohydrates thereby are digested and converted into glucose (blood sugar) at a slow, uniform rate. There is no insulin surge or spike needed to lower the blood sugar level. The water-retaining capacity of the gel also maintains bodily hydration (i.e., helping level out water intake) and electrolyte balance.


Considered the king of mucilaginous (gel-like) slippery plants, marshmallow offers a unique composition of about 37% starch, 11% mucilage, and 11% pectin (including flavonoids and phenolic acids). When it reaches the colon, marshmallow gel will soften hardened fecal plaques and help to remove them from colon walls. It also acts as a soothing coating and internal moisturizer for the entire digestive tract. Like chia seeds, it neutralizes irritants often found in the intestinal system, and thereby greatly relieves irritation to the mucous membrane lining of the digestive tract.


The health benefits of slippery elm are rooted mainly in its soothing properties. This mucilaginous herb is effective when used internally for coating and soothing mucous membranes while also absorbing toxins that can cause intestinal imbalances. Slippery elm is an effective remedy for duodenal ulcers, gastritis, diarrhea colitis, irritable bowel syndrome, hemorrhoids, and heartburn. The benefits of slippery elm also extend to being a simple food. As part of a normal diet, the inner bark of slippery elm can be ground and eaten as porridge. This porridge is extremely nutritious and high in antioxidants having a consistency and taste similar to oatmeal. It is also a wholesome and sustaining food for infants and invalids.


Activated charcoal is charcoal that has been treated with oxygen to open up millions of tiny pores between the carbon atoms. The use of special manufacturing techniques results in highly porous charcoals that have surface areas of 300–2,000 square meters per gram. Charcoal works to trap toxins through “adsorption.” When a material adsorbs something, it attaches to it via chemical attraction. The huge surface area of activated charcoal gives it countless bonding sites for adsorbing toxins.

When certain chemicals pass next to the carbon surface, they attach to the surface and become trapped. Activated charcoal is excellent for trapping carbon-based substances (i.e., organic chemicals), as well as other chemicals such as chlorine. It is known to trap over 20,000 organic chemicals. Many chemicals are not attracted to carbon (sodium, nitrates, etc.) so they pass through charcoal. Because charcoal is not “digested” like food, it may remain inside the GI tract for a time, thereby continuing to actively remove toxins via the bowel.


Research has shown that spirulina promotes digestion and bowel function. It suppresses bad bacteria (including E. coli and Candida albicans yeast) and stimulates beneficial flora, including lactobacillus and bifidobacteria. Healthy intestinal flora (i.e., “good” bacteria) are a foundation for good health. They increase absorption of nutrients from foods and help protect against infection. In Japan, researchers found that spirulina significantly reduces kidney toxicity caused by mercury and three pharmaceutical drugs. This suggests benefits for humans suffering heavy metal poisoning. Additional research found that rats consuming spirulina or chlorella algae eliminated seven times the amount of dioxin (a highly toxic chemical) when compared to a control diet.


Like other types of dietary fiber, inulin also has the benefits of enhancing digestive and intestinal functions, reducing cholesterol, and preventing disease. In addition, inulin has one other major health benefit: it is a prebiotic that feeds the healthy microflora that boost your immunity. Not only does inulin actively promote the growth of existing strains of probiotics in your colon, but it also encourages implantation, survival, and growth of freshly consumed probiotics. By boosting the survival and growth of beneficial probiotics in the inner ecosystem, inulin improves digestion, immunity, and disease-fighting capacity of the body.


Ginger rhizome (Zingiber officinale) is an incredibly active and effective gastrointestinal aid with the following properties: 1) Contains a digestive enzyme whose effectiveness even exceeds that of papain; 2) Stimulates the flow of saliva and increases the concentration of the digestive enzyme amylase in the saliva; and 3) Activates peristalsis and increases intestinal muscle tone. Ginger is also known to be helpful in cases of nausea.


BIOVIN® Grape Pulp, Skin & Seed Extract (>85% OPCs): The BioVin® grape extract in Intestinal Rejuvenation Formula is extracted by ethanol and water and contains the highest percentage of OPCs of any product on the market. OPCs, a class of bioflavonoids, are one of nature’s most powerful free-radical scavengers. As bioflavonoids, OPCs help to increase the effectiveness of Vitamin C. OPCs cross the blood-brain barrier to provide antioxidant protection to central nervous system tissue. Studies have clearly demonstrated that OPCs improve and normalize capillary activity, strengthening capillary walls. OPCs bind to collagen fibers, realigning them in the process to a more youthful, undamaged structure. Elasticity, flexibility, and strength are thereby restored to connective tissue.


Licorice root soothes the GI tract and aids intestinal health. Licorice root is used effectively in those individuals suffering from peptic ulcer and chronic gastritis. It is used to soothe coughs and reduce inflammation, soothe and heal ulcers and stomach inflammation, control blood sugar, and to balance hormones. Licorice is a potent antiviral agent and can be used to treat flu, herpes, and even hepatitis. Licorice is also a strong anti-inflammatory agent.

MAGNESIUM (from magnesium ascorbate)

Magnesium is important for the metabolism of many biologically active nutrients and substances, including calcium, potassium, phosphorus, zinc, copper, sodium, lead, cadmium, hydrochloric acid (HCl), acetylcholine, and nitric oxide (NO). It is required for more than 325 magnesium-dependent enzymes, cellular homeostasis, and activation of the B vitamin thiamin. It mediates the functions of the nervous and endocrine systems, supports proper muscle and nerve function, stabilizes heart rhythm, helps to regulate blood sugar levels, and supports normal blood pressure. Magnesium is important in energy metabolism and the synthesis of proteins.


Chlorella Growth Factor (CGF) stimulates lactobaccilus (the “good” bacteria) to grow at four times the usual rate. Experiments with microorganisms, young animals, and children have demonstrated that CGF promotes faster than normal growth. In adults and mature organisms, CGF appears to enhance the functions of nucleic acids at the cellular level that relate to the production of proteins, enzymes, and energy. It also stimulates tissue repair and offers protection against toxic substances at the cellular level.

VITAMIN C (from magnesium ascorbate)

Vitamin C is known to perform many critical functions within the body involving detoxification, tissue building, immune enhancement, pain control, and controlling or killing pathogenic organisms. It is known to be helpful for wound and bone healing, healthy skin and eyes, infections, stress control, toxic exposure, and repairing damaged tissue of all types.


Additional Ingredients: Natural Lemon Flavor, Malic Acid, and Stevia Leaf Extract. These natural flavors and taste enhancers give the formula a pleasing taste and make it easier for individuals to consume.

DIRECTIONS: For long term, gentle rejuvenation of the intestinal tract take about one (1) teaspoon (about 1/3 scoop) several times daily away from food (by at least 20 minutes), or as directed by a health care professional. Place the powder in about 8 ounces of water, thoroughly mix (shake or stir), and drink immediately (before the formula becomes a gel too thick to easily consume).

For a more rapid healing cleanse take one tablespoon (one scoop) multiple times daily away from food (by at least 45 minutes). Add the powder to about 16 ounces of water, mix vigorously, and drink.

We recommend using a suitable container (such as a mason jar) for rapid mixing. Stir rapidly or shake vigorously (with lid attached).

Individuals suffering from conditions of severe diarrhea and loose stools can take one tablespoon (or more) multiple times daily (five times or more) and refrain from food. Put the powder in about 16 ounces of water per tablespoon, thoroughly mix, and drink immediately. In between servings it may be helpful to take 10–20 billion organisms of a multiple strain lactic acid bacteria formula (i.e., a probiotic such as Prescript-Assist). Place the formula directly in your mouth, chew, and then swallow.

While results can be obtained rapidly using this formula, it is most effective when used for longer-term gentle cleansing. Starting with lower doses and gradually increasing dosage often produces best results. This allows the body time to adjust to increased dosages (size and frequency) and facilitates greater therapeutic action from usage.

Note: Taking large amounts without sufficient liquid (e.g., water) or when first taking the formula can slow bowel transit time. Therefore, most individuals will benefit from starting at lower dosage levels and ensuring adequate fluid intake when consuming the formula.

External Applications: Make paste by mixing powder with water. Apply directly to skin or affected areas (e.g., stings, bites, wounds). Wrap with gauze, plastic, etc., and keep poultice moist. Use for up to six hours. Apply fresh poultice as needed. For more information, see the Insect / Bee / Snake Stings and Bites Supplement and Activity Schedule.

Intestinal Rejuvenation Formula does not contain wheat, gluten, rye, oats, corn, barley, soy, yeast, egg, sugar, dairy products, GMOs, wax, animal fats, preservatives, colorings, or artificial flavorings.

intestinal rejuvenation formula specific condition doctor liers original

Intestinal Rejuvenation Formula is an effective, specific-condition formula for gut health.


“Health begins in the gut,” the saying goes. If true, and it seems likely to be, then taking care of the GI tract is more important than ever. This makes sense given the prevalence and multiplication of environmental and lifestyle factors capable of damaging the gut.

These environmental and lifestyle factors include, but are not limited to, 1) the use of antibiotics (both prescribed and found in foods), 2) genetically modified organisms (GMO), 3) the presence in foods (and water, soil, and air) of herbicides like glyphosate sprayed on GMO crops; glyphosate can loosen tight junctions in the GI tract to allow food proteins into the bloodstream, 4) Food proteins (e.g., gluten and gliaden) capable of damaging the gut, 5) dysbiosis, 6) lack of microbiome diversity, and 7) many others.

The solution to these problems is complex, and partly resides in utilizing a combination of strategies and supplements capable of addressing the different aspects and causes of reduced or impaired gut function.

Intestinal Rejuvenation Formula represents one type of supplement known to be helpful in repairing, restoring, and maintaining healthy gut function.


“Intestinal Rejuvenation Formula works well for cleansing. It also helped stop runny stools I had after eating out while traveling.” – T.T., Seattle, WA




Dr. Mark Sircus’s blog article at www.DrSircus.com:
“Apples – Pectin – Intestinal Formula”

Kidney Cleansing with Juices & Herbs

Liver Cleanse with Juices & Herbs

Rejuvenation Program: Part 2 (Detoxification)

Death by One (Or Two) Thousand Cuts

Microbiome, Diet, and Prescript-Assist Probiotic and Prebiotic

Super Remedies for Stings and Bites

Understanding Glyphosate Toxicity: Interview with Genetic Engineer Thierry Vrain (Mother Earth News)


Brain Maker: The Power of Gut Microbes to Heal and Protect Your Brain for Life by Dr. David Perlmutter

Grain Brain: The Surprising Truth About Wheat, Carbs, and Sugar – Your Brain’s Silent Killers by Dr. David Perlmutter

Wheat Belly: Lose the Wheat, Lose the Weight, and Find Your Path Back to Health by Dr. William Davis



PRESCRIPT-ASSIST™ Probiotic Formula (soil-based organisms)

RESTORE For Gut Health (lignite formula)

(proteolytic enzymes)

(full spectrum plant enzymes)

Nascent Iodine

Magnesium Oil, Flakes, Gel



Dr Hank Liers PhD science behind MegahydrateI recently became aware of the health benefits of molecular hydrogen/hydrogen. We subsequently have written numerous blog articles on the subject (see resources section below), and elected to carry and endorse several products, including Active H2 and Megahydrate™. As a scientist, I am particularly impressed with the science behind Megahydrate, as well as the in-depth research studies carried out showing how it was developed and its health benefits.

For economic reasons, it is rare for a particular nutritional supplement to have in-depth scientific studies and clinical trials supporting its use. In this article, I will present some of the most relevant scientific information regarding Megahydrate.

 science behind Megahydrate

In a previous article “Water, Hydration, and Crystal Energy®” I discuss in-depth the science behind Dr. Patrick Flanagan’s use of nanometer-sized silica colloids to enable greater hydration of the body, enhanced absorption of nutritional ingredients into cells, and improved cellular detoxification.

In this article I will discuss the science and benefits of embedding hydrogen anions (hydride or H-) into these same nanometer-sized silica colloids that not only have all of the hydration benefits of Crystal Energy® but also exhibit potent antioxidant characteristics. The resulting substance is named by Dr. Flanagan “silica hydride” and his product that incorporates it is known as Megahydrate™ (originally Microhydrin™). The science behind the development of Megahydrate is provided below.


The details of the materials development are provided in an article by Cory J. Stephenson and G. Patrick Flanagan titled “Synthesis of Novel Anionic Hydride Organosiloxane Presenting Biochemical Properties” published in the International Journal of Hydrogen Energy 28 (2003) 1243–1250.

Synthesis of an anionic hydride from monomeric silsesquioxanes is described. The novel compound, dubbed “silica hydride” is the result of several newly synthesized compounds from an interstitially embedded hydride family. It is a hydride-based compound with H− ions interstitially embedded in a matrix of caged silica. This compound exhibits profoundly different characteristics than other known compounds in the hydride family. Unlike saline hydrides, the silica hydride demonstrates no overt or violent reaction with water or air. However, it is capable of generating aqueous reductive potential readings (ORP) of −750 mV for extended time periods. In vitro biological testing demonstrated no cytotoxicity induced by the compound while demonstrating efficacy as an antioxidant. In vivo studies of the compound have shown that it has a significant ability to reduce lactic acid build up in muscles by one-half after exercise. The synthesis of the silica hydride resulted in an approximately 16.8% w/w hydride content, as determined by density changes, proton NMR spectroscopy and ion beam analyses. Scanning and tunneling electron microscopy, Rutherford backscattering spectroscopy (RBS), forward recoil (FReS) ion beam analyses, in addition to Fourier transform infrared spectroscopy, reduction potential and 29Si CP-MAS solid state NMR were additionally used to characterize the compound.

Below relevant details from the article are provided to give insight into the science of the Megahydrate invention.

Introduction: The idea behind synthesis of the novel compound described in this article is based on the use of a monomer nanocomposite as a carrier in a bioencapsulated compound. The synthesis uses a silica and hydroxyl group terminated silsesquioxane monomer, trademarked Silica Microclusters®, that is interstitially imbedded with hydride anions as conceptually depicted in Fig. 1. The results from the characterization of this compound provide evidence to this claim, including DRIFTS FTIR and NMR data.

Figure 1 science behind Megahydrate

Figure 1. Conceptual diagram of Flanagan Microcluster structure. The tetrahedral coordination forms a three-dimensional framework by a series of Si–O–Si bonds, creating a silica cage.

With the immense potential for bioencapsulates and nanocomposite technologies, it would be very beneficial to create a hydride out of a compound that would involve the combinational reducing effects of a saline hydride compound and the beneficial attributes of the host compound, all without the reactivity of the saline hydrides. Synthesizing a biologically friendly hydride would have immense potential as an antioxidant and radical scavenger as discussed later in this paper.

It was discovered in the present work that if a hydride ionic plasma was placed under pressure, virtually any compound it came in contact with could then absorb its emitted ions. Since the 1920s, creating a hydride gas has been standard practice. One effective way is to add a current to a tungsten (W) lament in a hydrogen gas atmosphere. The lament separates hydrogen gas into a monovalent hydrogen gas while the photoelectric effect on the W lament donates electrons to the H gases forming a H− plasma. Langmuir, in 1927, while using the W lament hydride ion synthesis technique, discovered that moist air prevents hydride ions from recombining back into hydrogen gas.

Figure 2 science behind Megahydrate

Figure 2. The Concept of Silica Hydride. Conceptually the hydride embedded organosiliceous silsesquioxane, or silica hydride, is a monomeric silica-based cage with interstitially placed hydride anions. As a bioencapsulated compound, the silica acts as a colloidal carrier for the hydrogen anions in solution.

Details of Invention: The idea for this synthesis experiment was to then create a hydride plasma under a water vapor atmosphere and expose the plasma to an organosilicate compound, circumventing the problem of the hydrogen not having the catalysis or the electron availability to combine with the host substrate. Interestingly, Langmuir noted that the monoatomic ions produced by this process would become embedded in the glass walls of the tubing of his apparatus and that same tubing could later be induced to release the ions. The glass tubing used by Langmuir was a borosilicate glass, an amorphous siliceous compound. In the present study, an apparatus similar to what Langmuir used was constructed to create a plasma of H− ions. The H− atmosphere was applied to the pure Microcluster Silica powder under pressure and in the presence of a water vapor, creating a novel silsesquioxane bioencapsulated-hydride compound, dubbed: silica hydride.

Materials and methods: A 1.0 L sealed glass vessel was fabricated containing the items as depicted in Fig. 3. Two 5 cm × 0:6 cm diameter W rods were positioned transversely 2 mm apart in the top of the reaction vessel with two insulated leads connecting the W rods to a 20 A constant-current transformer (Lambda-EMI 102A-1KV, Neptune, NJ). Ten grams of MicroclusterJ silica was placed on the stage inside the vessel with 100 ml of distilled and deionized water added to the basin. A steady stream of hydrogen gas was bubbled through an aquarium stone in water and introduced to the reaction vessel, purging all of the air from the vessel and increasing pressure to 172 kPa at which time the vessel was sealed. A 500 V potential was applied to the W rods. At voltages ranging from 350 to 750 V, a constant arc could be maintained between the electrodes without melting. The potential was applied for 30 seconds at which time the current was shut off  and additional hydrogen was pumped into the vessel creating a captive plasma. The sample was allowed to sit in the plasma for 30 minutes at which time the silica sample was removed and weighed with an analytical balance.

Figure 3 science behind Megahydrate

Figure 3. Synthesis Apparatus. The representation of the apparatus used to synthesize the compound. A hydrogen gas generator (A) provides H2 gas that is sparged through a fllter stone in deionized, distilled water (B), where the hydrogen gas and water vapor are transported into a reaction vessel (C) with the substrate. Two tungsten electrodes (D) create a captive plasma H− gas via a constant current high-voltage power supply (E). Vessel evacuation, purge and sealing were performed using a mechanical valve (F). The resultant actions interstitially embed the hydride anions created by the plasma into the substrate.

Results: Determination of the mass of the anionic hydride organosiloxane sample showed an increase from 10.0 to 11.70 g upon exposure to the hydride plasma under pressure. The sample was allowed to sit at room temperature with desiccant in a glass vial for 3 weeks at open atmosphere at which time the proceeding analyses were performed.

An ion beam analysis was performed with the silica powder being pressed into a pellet (1.66 g/cm3) compared to a control standard. Rutherford backscattering spectroscopy (RBS) was analyzed with 2 MeV He beam, while 3 MeV He beam was used in a forward-recoil spectrometry (FReS) measurement. RBS suggests that the powder contains elements O and Si. Including H- content by FReS, the powder relative percentage makeup becomes H (78.1%), O (15.6%) and Si (6.2%). Trace amounts of boron (B) and W (<25 ppm) were also observed. Original values from samples of non-reacted Microcluster silica comparatively illustrate an elemental makeup of H (22.4%), O (55.6%) and Si (21.9%). A 1H-NMR characterization was performed and showed a 16.8% hydride content.

Scanning electron microscopy analysis with a 40 KeV-JEOL 840II microscope illustrated small, ∼ 2 microns, spheres consisting of numerous smaller spheres. A 300 KeV-CM30 transmission electron microscope allowed the resolution to image very small, spherical compounds that were measured to be about 50 Angstroms. An energy dispersive X-ray spectrometer qualified an elemental analysis of the compound to contain Si and O.

The ORP and pH were recorded for 250 ml distilled and deionized water in a Pyrex beaker. 10.0 g/ml of the siliceous hydride was added to the beaker and allowed to stir for 15 min at which time addition ORP and pH readings were taken. The initial ORP and pH of the water averaged 341.33±2.5 mV and pH 7.12±0.06, respectively. The readings after 15 min were −436.21 ± 2.1 mV for the ORP and 9.13 ± 0.09 for the pH measurements.

The hydrogen pressure unbiased reducing potential, rH, was calculated. The use of rH gives a hydrogen proton-unbiased look at the absolute reducing potential of a compound, eliminating the effects of pH in the ORP measurement. The measured rH for the compound was 11.02 ± 0.04 indicating a highly reduced environment.

Discussion: The synthesis process appears to cluster the organosilicate subunits into hydrogen-bonded aggregates that further group into approximately 2 micron clusters as shown in Fig. 4A. Dissolution in water decreases the cluster size from 2 microns to the smaller subunits of about 500 nm, then into individual cages of about 50 A (Fig. 4B).

 Figure 4 science behind Megahydrate


This new organosilicate silsesquioxane compound, commonly named silica hydride, has been the subject of numerous tests involving reduction potential (ORP) and pH as well as being analyzed as an effective antioxidant. Adding a few mg to water will drop an ORP reading by −750 mV. A recent publication of a clinical study has illustrated the capability of this compound to significantly reduce lactic acid after exercise by 50%. Viability and cytotoxicity probes show that the silica hydride does not cause any decrease in intracellular esterase activity or otherwise induce a toxic cytoplasmic environment. There are a plethora of uses of a hydride-based compound such as silica hydride since it does not impose a direct negative effect to cellular viability and cytoplasmic health. Particular uses include nutritional supplementation as an antioxidant. The incredible reduction potential of silica hydride adds to the possible uses of this type of compound.

The compound does not react violently or visibly with H2O. However, it will reduce the ORP reading to −750 mV for a period of at least several weeks. Most antioxidant compounds are relatively large chemical species. Examples of this are vitamins A, K, C, ubiquinone and n-acetyl-l-cysteine. It is hypothesized that steric hindrances may affect the efficacy of antioxidants. The small size and reducing capacity of silica hydride, the silsesquioxane hydride compound, may lead to future development as an antioxidant.

Conclusion: The novel siliceous compound acts as a colloidal carrier for the very small hydride anions that are released in an aqueous solution. This nanosized colloidal bioencapsulated compound could be an incredibly effective radical scavenger and aid in the reduction of oxidative stress due to its minimal size and high reduction potential.

This novel compound presented in this paper has demonstrated promising in vitro and in vivo biochemical significance with uses including reducing agents, antioxidants and nutritional supplementation. The synthesis is simple and effcient with consistent results of about 17% w/w hydride content with respect to the starting compound. Biologically friendly compounds that incorporate health-beneficial minerals, such as silica, with the scavenging and reducing capabilities of a hydride provide for numerous possibilities of uses.


After inventing Megahydrate (formerly Microhydrin), Dr. Flanagan (and his associates) conducted studies on its efficacy for a range of benefits for human health. The material was then patented in 2003. Key elements of the patent are provided below and a link to the entire content is provided if you wish to read further details.

Methods of using silica hydride mineral
US 20030190374 A1


The exact health benefits of silica hydride minerals, traditionally found in glacial streams, have long been the subject of speculation. Geochemical analysis indicates that such colloidal silica hydrides in water possess a silica-water interface that provides a hydrated surface and adsorbs other elements or compounds such as potassium, iron, magnesium, lithium, calcium, and hydrogen. Dietary supplements with similar properties have been formulated. When the silica-water interface of such compounds is saturated with reduced hydrogen, the compounds take on an overall negative charge and act as a reducing agent or antioxidant when in solution. When consumed, hydride ions introduced into the body by the silica hydride supplement donate electrons to body fluids. With proper dosages, the benefits of consuming silica hydride include reduction of lactic acid build-up, increasing cellular hydration, reduction of free radical damage, enhancement of mitochondrial bioenergetic capacity, increasing antioxidant activity, and enhancing the properties of drinking water.


This invention relates to methods of using silica hydride minerals. More particularly, this invention relates to methods of using silica hydride minerals that have beneficial effects on lactic acid buildup during exercise, cellular hydration, free radical damage, mitochondrial bioenergetic capacity, antioxidant activity, and the suitability of water for conversion into optimal cellular body fluids.

Amorphous silicate minerals, many of which are in the nanoparticle size range, were once common in natural water sources and abundant in glacial stream waters. Not only do the silica mineral particles bond water and other elements for transport; they also can be adsorbed with reduced hydrogen, which releases electrons, providing antioxidant or reducing potential to surrounding fluids.

In one region of West Pakistan the people are known to enjoy excellent health and amazing longevity. A team of cardiologists found the heart health of the people to be exceptionally good and evidence of the people’s delayed aging. The cardiologists attributed the good health and longevity in significant part to the abundance of colloidal silicate minerals in the glacial streams the people used for irrigation of food crops and drinking water.

Geochemical analysis indicates that colloidal silicate minerals display a variety of properties, including the formation of structured water around the silica-water interface, which provides a hydrated surface that adsorbs elements or compounds such as potassium, iron, magnesium, lithium, calcium, and hydrogen. FIG. 5 illustrates an example of the silica-water interface and the concentric structured water arrangement about the interface with the adsorption of elements within the layers.

Figure 5 science behind Megahydrate

Figure 5. An enlarged view of a hypothetical silica hydride particle showing the silica-water interface and other adsorbed elements.


From silicate analogs, it is possible to formulate dietary supplements that are similar to the colloidal silicate minerals found in glacial waters and retain the geo-physical properties inherent to these minerals. An example of such synthesized silicate analogs is a silica hydride formula sold under the trademark Microhydrin®. Substances possessing the characteristics and functions described in this application, such as Microhydrin®, have assumed many names.

For example, in addition to being called silica hydrides, such substances are known as amorphous silicate minerals, silicate particles, silicates, colloidal silicate minerals, silicate analogs, synthesized silicate analogs, functional silicate nanocolloids, dielectric interstitial hydrides, dietary silicate supplements, or dietary silicate antioxidants. Considering the many labels afforded this class of substances, the characteristics and functions of supplements must necessarily determine whether a particular supplement falls within the class.

Referring again to FIG. 5, the particle’s silica-water interface can be saturated with reduced hydrogen, or hydride (H-) ions, and takes on an overall negative charge. In such cases, the particle then acts as a reducing agent or antioxidant when in solution (standard reduction-oxidation potential, −550 mV). It is capable of providing literally trillions of hydride ions able to donate electrons into body fluids.

Electrons, which Albert Szent-Gyorgyi called the “fuel of life,” are abundantly available in inorganically grown raw vegetables, fruits, and grains, but are deficient in our modem diet of over-cooked, acidic, or highly oxidized foods, beverages, and drinking water. In silica hydride minerals, the structured water around the silica-water interface stabilizes electron transfer. Such specific silicate interactions could play a substantial role in many biological processes by enhancing salvation properties and ion and water transport and by providing free radical antioxidant protection.

Such electron deficiencies resulting from inadequate diet have a derogatory impact on specific biological processes such as lactic acid build-up, cellular hydration, damage from free radicals, mitochondrial bioenergetic capacity, antioxidant activity, and suitability of drinking water for conversion into optional cellular body fluids. Therefore, a need exists for a method of counter balancing these electron deficiencies and, as a result, enhancing each of these biological phenomena.

The present invention identifies certain beneficial health effects of silica hydride minerals and the effective doses necessary to achieve desired results. With proper dosages, the benefits of using silica hydride minerals as a dietary supplement include: reduction of lactic acid buildup during and after exercise, increasing cellular hydration, reduction of free radical damage, enhancement of mitochondrial bioenergetic capacity, increasing antioxidant activity, and enhancing the suitability of water for conversion into optimal cellular body fluids.


1. A method of reducing lactic acid buildup during and after exercise comprising ingesting an effective dose of silica hydride mineral.
2. A method of increasing cellular hydration comprising ingesting an effective dose of silica hydride mineral.
3. A method of reducing free radical damage comprising ingesting an effective dose of silica hydride mineral.
4. A method of enhancing mitochondrial bioenergetic capacity comprising ingesting an effective dose of silica hydride mineral.
5. A method of increasing antioxidant activity comprising ingesting an effective dose of silica hydride mineral.
6. A method of making water more suitable for conversion into optimal extracellular and intracellular body fluids comprising ingesting water mixed with an effective dose of silica hydride mineral.
7. A method of improving the characteristics of body fluids, such as saliva pH, saliva rH2, blood resistivity, urine resistivity, urine pH, urine rH2, and saliva resistivity comprising ingesting an effective dose of silica hydride mineral.


  • Contains Hydrating Silica Microclusters®
  • Extremely Powerful Antioxidant
  • Recycles other Key Antioxidants in the Body
  • Extremely Safe and Non-Toxic
  • Easily Accesses All Cells in the body
  • Increases Cellular ATP Production by up to a factor of 4 times
  • Readily Converts NAD+ to NADH
  • Reduces Pain & Inflammation
  • Exhibits Powerful Anti-Aging Properties
  • Protects and Repairs DNA
  • Neutralizes Harmful Toxins like Fluoride, Chlorine, etc.
  • Protects Against and Repairs Radiation Damage
  • Increases Absorption of other Supplements
  • Lowers surface tension of water you drink leading to improved detoxification
  • Removes Heavy Metals from the Body
  • Balances pH or Alkalizes the body
  • Increases Zeta Potential of Human Cells
  • Increases Cellular Hydration
  • Very Stable – Works Over Extensive Time Periods
  • Reduces Lactic Acid Buildup During Intense Workouts
  • Protects Telomeres by allowing cells to exceed the Hayflick limit by 4-5 times


Molecular Hydrogen Foundation (MHF)

Hydrogen for Optimal Health
by Fred Liers, PhD (from the HPDI blog)

Wonders of Molecular Hydrogen
by Fred Liers, PhD (from the HPDI blog)

Molecular Hydrogen (H2) at the Forefront of Health Research
by Hank Liers, PhD (from the HPDI blog)

ACTIVE H2 (tablet)

H2BEV (bottle)

MegaHydrate™ (capsule)

Contact Us:

You can reach HPDI by calling 1-800-228-4265, email support(at)IntegratedHealth.com, or visit the retail website: www.IntegratedHealth.com

Health care professionals and retailers can apply for wholesale account, which includes access to the HPDI reseller website: www.HealthProductsDistributors.com



Fred Liers PhD molecular hydrogen H2In recent months, I researched and sampled different hydrogen products, including molecular hydrogen and anionic hydrogen products. I posted an article titled Wonders of Molecular Hydrogen last month.

This month I continue writing about benefits of hydrogen for health. Yet, in today’s post I document my personal experience with it, as well as the experiences of a few other individuals who have benefitted from it.

For those who don’t know—and that included me not long ago—hydrogen is the subject of more than 500 peer-reviewed papers in the scientific literature. Hydrogen is rapidly becoming recognized as an important nutrient for health.

According the Molecular Hydrogen Foundation, studies show hydrogen to exhibit therapeutic potential in nearly every organ of the human body, and in 150 different human disease models.

As such, there is an explosion in the amount of research on hydrogen, and quantum leaps are being made in understanding its importance for health.


I began testing hydrogen products a few months ago. I began by drinking a pre-bottled hydrogen beverage known as H2Bev. Shortly thereafter, I sampled a tablet form that effervesces (fizzes) in water called Active H2.

MegaHydrate Active H2 molecular hydrogen

MegaHydrate and Active H2 are two products providing hydrogen I tested.

Since then I have tried other delivery methods, including a unique encapsulated product known as MegaHydrate, which provides hydrogen anions. I experience benefits from all of them. HPDI now carries all three products.

Here are benefits I notice after using all three products providing hydrogen:

• Greater Physical and Mental Energy. The first benefit I noticed was a increased physical energy closely followed by greater mental energy. This helps me throughout my day, especially in the later afternoons. If I experience a lull in energy, I can take an Active H2 tablet in water or a MegaHydrate and feel an immediate lift.

• Faster Recovery after Exercise. I frequently hike, as well as participate in aikido, yoga, and sometimes run. In each case, I notice decreased recovery times.

• Increased Clarity and Focus. This benefit perhaps relates to increased mental energy. However, beyond mental every itself, I experience clearer thinking and a better ability to focus.

• Less Need for Sleep. I can fall asleep later or wake earlier, with less tiredness during the day. I am not prevented from sleeping. I can just get by with less when necessary, it seems.

• Improved Mood. Maybe this benefit relates to increased physical and/or mental energy. However, for me it means going through the day on an even keel. My mood is pretty good to begin with. I feel this benefit could relate to general feeling of well being I seem to gain when using the hydrogen products.

I experienced these benefits immediately after I began consuming hydrogen-infused water and the MegaHydrate (capsules). I continue seeing these benefits as I have keep taking hydrogen, and have increase my intake. In fact, it feels as if these benefits may accrue over time, so I will continue taking hydrogen over the course of weeks and months ahead.


Besides myself, I recently spoke to a few friends and family members, some of whom I gave samples of hydrogen products to try. Here are benefits they report:

• Increased Energy

Nearly everyone I speak to reports increased energy. This may be among the most important benefits because not only because we can all use greater energy, but also because it shows how rapidly and effectively hydrogen works in the body.

• Easier Breathing

Almost everyone who I spoke to who has tried one or more hydrogen products say they breathe easier because of it. One person said it really helped their exercise performance. Another person said that since allergy season has started, this benefit is major for them because usually early spring is a time of difficult breathing for them due to the prevalence of pollens and other plant allergens.

• Sounder Sleep

I personally have noticed I need less sleep. However, others report to me they sleep more soundly. It may be that improved breathing is the reason for sounder sleep. But it may also be they are simply sleeping more soundly as a result of taking the hydrogen. In either case, they enjoy sleeping more soundly.

H2Bev molecular hydrogen H2 product bottle

H2Bev hydrogen-enriched water is pre-bottled, ready to drink.


Now that I’m testing three hydrogen products and receiving their benefits, I don’t want to be without them. Who wouldn’t want increased physical energy or mental energy or improved breathing? And as much as I gain from a full night’s sleep, the benefit of being able to get by with a little less when necessary is nice.

I have noticed a few other benefits:

• The need for less nutritional supplementation. I will always take nutritional supplements, but I have reduced the amounts I take of certain supplements. This may be due to increased absorption relating to the hydrogen.

• Eating less. I am not sure whether this directly relates to consuming hydrogen. It may be more related to how the body assimilates nutrients when hydrogen is present in my body. In any event, I am eating less and I am less hungry. I’m not depriving myself, I just feel more satisfied from the foods I eat. I have also heard this from others using hydrogen. I’m not sure whether they consider it a benefit or a side-effect. For now, I’m just making observations.


It’s difficult to say which of the three products I’ve tested that I like best. Each appears to have its place in my life.

I enjoy the convenience of H2 Bev when I’m traveling or even just taking a day trip. I can grab a bottle or two and go. I don’t have to worry about mixing tablets with water or taking an extra container with me, or remember to take a capsule.

Active H2 is great, too. It only takes a few minutes for the tablets to fizz. I use a glass or metal container. I would say that ounce-for-ounce Active H2 provides more hydrogen than H2Bev, so this is an advantage to me. Both of these products ensure hydration because you’re drinking water infused with hydrogen.

Megahydrate is the easiest to take due to its capsule form. I feel it offers more noticeable effects (and maybe 2–3 times as much hydrogen per dose as other products) and they last a long time. I don’t necessarily drink much water when taking Megahydrate, but it helps when I do. I need to remember to drink it with sufficient water, perhaps six to twelve ounces.

I really like Megahydrate, and it offers certain advantages. It has broad applicability like other hydrogen products. But it is unique because it has different modes of action containing an abundance of negative hydrogen ions within a colloidal silica matrix.

In fact, Megahydrate may be the ultimate hydrogen product (even better than molecular hydrogen). This is because it not only greatly enhances the production of ATP (cellular energy) in the body and the hydrogen it provides acts as a powerful antioxidant, but also because it can unlock the potential of water as a medium for nutrient replenishment and waste removal at the cellular level. This makes it a uniquely different product.


Hydrogen is a worthy supplement with much scientific literature behind it. The fact that I receive similar benefits from three different products speaks well for the science. Regardless of which hydrogen products I use on a given day, what I gain from them is what matters most.

I will continue testing products providing hydrogen. I will write additional blog articles and perhaps update this post, as well. I recommend individuals try molecular hydrogen products for themselves because I believe most people will benefit significantly from them.

We also recommend checking out the website of the Molecular Hydrogen Foundation (www.molecularhydrogenfoundation.org), which provides scientific studies and technical information about hydrogen.


Molecular Hydrogen Foundation (MHF)

Wonders of Molecular Hydrogen
by Fred Liers, PhD (from the HPDI blog)

Molecular Hydrogen (H2) at the Forefront of Health Research
by Hank Liers, PhD (from the HPDI blog)

ACTIVE H2 (tablet)

H2BEV (bottle)

MegaHydrate™ (capsule)

Contact Us:

You can reach HPDI by calling 1-800-228-4265, email support(at)IntegratedHealth.com, or visit the retail website: www.IntegratedHealth.com

Health care professionals and retailers can apply for wholesale account, which includes access to the HPDI reseller website: www.HealthProductsDistributors.com