0

BONE FRACTURES SUPPORT

Dr. Hank Liers, PhD bone fracturesSeveral years ago a customer asked me for a program that could be helpful to those suffering with bone fractures. A relative had been diagnosed with multiple bone fractures in his ankle.

Since I have been counseling individuals regarding natural treatments for supporting those with bone fractures and injury for many years, I was able to provide a comprehensive program that could be helpful in recovery. More recently, we have introduced products and tools that can be even more supportive. Therefore, in this article we are providing an update to the bone fractures program.

Clearly, the need for such a program is great. According to the American Academy of Orthopaedic Surgeons (AAOS), about six million individuals suffer fractures each year in North America. In about 5–10 percent of cases, patients suffer either delayed healing or fractures that do not heal.

The problem of bone fractures is especially troubling for the elderly, many of whom suffer from osteoporosis, a condition in which bones become weak and break more easily. For an older person, a fracture affects quality of life because it significantly reduces function and mobility, and requires an extended period of recuperation.

The bone fracture program set forth below also works well to support the healing of other types of bone problems, including broken bones, bone surgery, osteoporosis, and wisdom tooth removal.

THE BONE FRACTURE PROGRAM

IMPORTANCE OF FOUNDATIONAL SUPPLEMENTS

The first element of the program consists of Foundational Supplements. This group of supplements ensures the body is being supplied with all of the basic elements needed for optimal function. The primary foundational supplements consists of 1) a therapeutic multivitamin and mineral formula, 2) a complete buffered Vitamin C with antioxidants formula, 3) an essential fatty acids supplement, and 4) a high-RNA superfoods formula.

Our Foundational Supplements are described in great detail on the HPDI website where we provide a free downloadable e-book “The Need for Foundational Supplements” (.pdf). Suffice it to say that the foundational supplements are a essential part of the program that ensure healing will take place quickly and effectively. I encourage everyone to become familiar with this information as foundational supplements are basic to any wellness or healing program.

bone fractures

ENHANCEMENT FORMULAS ARE CRITICAL FOR HEALING BONE FRACTURES

The second element of the program for healing bone fractures consists of Enhancement Formulas that strengthen the body as it relates to dealing with the damaging effects of bone fractures. These include a Vitamin D3 formula with the synergistic nutrients of Vitamin A and Vitamin K2 that are required for the rebuilding of bone as well as strengthening the body in many other ways. The HPDI Vitamin D3 Plus formula to designed to specifically address this need.

A second Enhancement Formula in this program is our comprehensive Bone Guardian formula that is based upon micronized veal bone that provides hydroxyapatite (Ca10(PO4)6(OH)2). Hydroxyapatite is the basic component of human bone that is 50% by volume and 70% by weight. Whereas the Vitamin D3 Plus formula builds the bone matrix, the Bone Guardian fills in the matrix with materials such as calcium, phosphorus, magnesium, boron, zinc, manganese, copper, silica, and strontium. HPDI sells Bone Guardian in both the tablet and capsule forms. The capsule form may be better for older people who are able to absorb capsules better than tablets.

A third Enhancement Formula to the program is additional amounts of Vitamin C. Vitamin C is known to participate in every step of the process of building collagen, which is a key component of bone. Vitamin C has been shown to increase bone mass density. We recommend slowly increasing your intake of buffered Vitamin C until you reach your bowel tolerance. This can be accomplished by increasing your intake of HPDI’s foundational supplement PRO-C™ formula. The PRO-C has the added value of containing oligomeric proanthocyanidins (OPCs) from grape seed, skin, & pulp. OPCs in the body are able to strongly crosslink and strengthen new and damaged collagen fibers needed needed to repair bones, ligaments, tendons, and cartilage.

SPECIFIC CONDITION FORMULAS TARGET BONE FRACTURES

The third element in the program are Specific Condition Formulas that directly address issues related to bone fractures. The first of these is the addition of a joint formula that allows the body to build and repair connective tissue and to significantly reduce inflammation in the area of bone fractures. In most cases of fractures there will be damaged ligaments and tendons as well as inflammation in the area.

HPDI’s Joint Health Formula includes the ingredients glucosamine hydrochloride, MSM, and sea cucumber (a significant source of chondroiten sulfate) in addition to anti-inflammatory substances such as turmeric extract, rutin, and grape extract (seed, pulp, and skin) that have been extremely helpful in both repairing connective tissue and reducing pain and inflammation.

A second strongly recommended condition-specific formula is proteolytic enzymes. Because it is highly likely in the case of bone fractures and injury that there is significant tissue damage, a formula with pancreatic and plant enzymes as well as anti-inflammatories can be extremely helpful is clearing out the damaged tissue. This gives the body the opportunity to begin the rebuilding process much sooner.

Our recommended PROLYT formula contains the proteolytic enzymes bromelain, trypsin (pancreatic enzyme), and chymotrypsin (pancreatic enzyme), and the polyphenols/bioflavonoids turmeric extract (95% curcuminoids), quercetin and oligomeric proanthocyanidins (OPCs) from grape extract. This formula when taken on an empty stomach between meals is quickly absorbed into the bloodstream and goes to work cleaning up any damaged tissues in the area surrounding a fracture and assists in reducing pain and inflammation.

TOPICAL MAGNESIUM CHLORIDE FOR PAIN AND RAPID HEALING

A final Specific Condition Formula that I highly recommend for healing bone fractures is to rub Ancient Minerals Magnesium Oil on and surrounding the fracture area. Bones cannot heal without having adequate amounts of magnesium available. Unfortunately, many people are deficient in magnesium and even taking oral magnesium cannot easily provide sufficient amounts to an area with a bone fracture. Magnesium oil (mostly magnesium chloride) is quickly absorbed transdermally (via skin) and often can provide rapid healing and pain relief!

BODY pH COULD BE A FACTOR IN HEALING BONE FRACTURES

The processed food diets with a high protein and low vegetable content consumed by many people in the U.S. and elsewhere often produce conditions in the body of acidity. This in turn leads to decreased oxygenation of cells and encourages a greater amount of anaerobic processes in metabolism. In addition, when the body is acidic calcium can be taken from bones in order to balance the acidity. This can lead to poor healing of bone fractures.

In order to counter acidic conditions in the body we recommend the use of HPDI’s pH ADJUST formula. As a dietary supplement, take 1 gm (about a rounded ¼ tsp) in 4-8 ounces of purified water preferably away from food, or as directed by a health care professional.  For extremely acidic conditions, try 4–10 doses per day, depending on acidity level. Use pH paper to ensure pH levels remain balanced, and do not become too alkaline (alkalosis may occur above pH 8.2).

TESTING pH LEVELS: The best way to test pH levels is to use litmus paper, which HPDI offers in rolls (Hydrion brand) for this purpose. You can test salivary or urinary pH. In order to test salivary pH, simply use a small strip of pH paper to dip into a small amount of saliva. Advantages of pH paper include rapid results, ease of use, and cost effectiveness.

pH Paper bone fractures protocol

The color of the litmus paper indicates the pH level of the body fluid tested. Most litmus paper comes with an indicator chart showing colors corresponding to various pH levels. Alkaline states will generally produce a dark green, blue or purple color (most basic). Acidic states will range from yellow (most acidic) to light green.

Salivary pH and urinary pH are significantly affected by recent food consumption and other factors, so it it best to test pH hours after meals or in the morning when you awake. We prefer to measure urinary pH since results are more consistent. Measuring urinary pH is a simple as placing a few drops of urine on the paper or dipping the paper into a sample cup of fresh urine.

A consistent pH measurement of less than 7.0 indicates that you are too acidic (values less than 6.2 show extreme acidity). This indicates that you should consume more alkaline forming foods (usually vegetables) and/or take pH ADJUST. A single dose of pH ADJUST can change conditions in the body from acidic to alkaline within a few hours.

GENETIC VARIATIONS IN YOUR VITAMIN D RECEPTOR GENE (VDR) MAY BE AN IMPORTANT FACTOR

The VDR gene (contained in every cell of the body) provides instructions for making a protein called vitamin D receptor (VDR), which allows the body to respond appropriately to vitamin D. This vitamin can be acquired from foods in the diet or made in the body by exposure to from sunlight. Vitamin D is involved in maintaining the proper balance of several minerals in the body, including calcium and phosphate, which are essential for the normal formation of bones and teeth. One of vitamin D’s major roles is to control the absorption of calcium and phosphate from the intestines into the bloodstream. Vitamin D is also involved in several process unrelated to bone formation.

VDR attaches (binds) to the active form of vitamin D, known as calcitriol. Calcitrol is produced in the body from Vitamin D3 (cholecalciferol) in the liver and kidneys. The interaction with calcitriol allows VDR to partner with another protein called retinoid X receptor (RXR). The resulting complex of proteins then binds to particular regions of DNA, known as vitamin D response elements, and regulates the activity of vitamin D-responsive genes. By turning these genes on or off, VDR helps control calcium and phosphate absorption and other processes.

In recent years, genetic tests have become available that show VDR variations can cause serious conditions related to low bone density and other important body functions such a higher blood glucose levels or lower immune system function. If a person is having little success in healing bone fractures, it is possible that VDR variations are a key factor of causation.

In such cases, we recommend having genetic testing done to determine if VDR variations are present. Recently, HPDI has teamed with a genetic testing company (BodySync, Inc.) and sells the BodySync test kits on our Reseller site. Please click here to see our blog article regarding the BodySync genetic test. Among the genes tested for in the test are three variations of the VDR gene. Resellers can purchase the test kits directly from HPDI and retail customers can call us  (800-228-4265) to find out how we can help them get a test kit and support them with any associated counseling regarding the results.

SUGGESTED SUPPLEMENT SCHEDULE – BONE FRACTURES

I have included all of the above supplements including recommended dosages plus more related to having an excellent diet in the table provided below.

Description AM Noon PM Night Comments
PRO-C 2 caps 2 caps 2 caps Take with meals or with snack.
Bone Guardian 

Bone Guardian Caps (easier to absorb)

3 tabs

3 caps

 

3 caps

3 tabs

3 caps

Take with meals.

Take with meals.

Mighty Multi-Vite! or
Multi Two — Multivitamins
2 caps or
1 tab
2 caps or
1 tab
Take with meals.
Essential Fats plus E 2 softgel 2 softgel 2 softgel Take with meals.
PROLYT – Proteolytic Enzyme Formula 2 caps 2 caps 2 caps 2 caps Take between meals.
Buffered Vitamin C, Tablets — 1,000 mg (1 gm) or Powder (1/4 tsp = 1 gm) 2 tabs or
1/2 tsp
2 tabs or
1/2 tsp
2 tabs or 1/2 tsp 2 tabs or 1/2 tsp Best with meals, but other times are okay. Start with 2 tabs or 1/2 tsp twice per day and add another 2 tabs or 1/2 tsp every few days until you are taking 8 tabs or 2 tsp per day.
Vitamin D3 Plus 5,000 IU 1 softgel 1 softgel Take with meals. Reduce to 1 softgel after 2 months.
Joint Health Formula 2 caps 2 caps 2 caps Take between meals and away from Bone Guardian.
Magnesium Oil 10 pumps 10 pumps 10 pumps 10 pumps Spray on affected area – or nearby area.
Rejuvenate! Plus or
Rejuvenate! (original)
1 scoop 1 scoop Take as a meal by itself or with fruit/berries.

ADDITIONAL NUTRIENTS FOR BONE FRACTURES

Additional nutrients that may be helpful include pH ADJUST (to balance excess acidity in the body),  Warrior Mist™ for pain relief (rub on adjacent area several times daily), Echinacea (as drops or capsules), N-Acetyl-L-Cysteine – NAC (2 gms per day), Progesterone Cream – for women (1/4–1/2 tsp twice daily), and Prescript-Assist™ probiotics (2 capsules daily) if on antibiotics.

PROPER DIET IS ESSENTIAL

Consume a diet that provides good amounts of protein which is needed by the body to support the healing of bone fractures. Eat meats, poultry and fish (e.g., sardines, salmon, mackerel) in the amount of a 5–10 ounces per day. Ensure a good intake of organic vegetables, including high levels of dietary fiber. Drink 16 oz per day of fresh vegetable juices from carrot, celery, beets, cabbage, etc.

Other healthy foods (preferably organic) include fruits, whole grains (e.g., brown rice, millet, and quinoa), beans, nuts and seeds (sunflower, chia, flax, pumpkin, almond, walnut and sesame in small amounts — 2 or 4 ounces — are good). Try eating Hank’s Vegetable Soup several times a week. Avoid all sweets (sugar), processed/refined foods (white bread and pasta), preservatives, and artificial flavors and colors. Vary your diet.

HYDROTHERAPY (WATER THERAPY) FOR BONE FRACTURES

An additional treatment that can be useful is hydrotherapy. In particular, hot and cold showers are a very effective way to move the blood and create circulation. This can speed up both detoxification and delivery of healing nutrients to the area of a bone fracture. Here’s how to do this. Once daily, take a complete hot and cold shower. You will start with hot water for one minute, then cold for one minute. Repeat this seven (7) times so the shower should last about 15 minutes.

Another time, daily, you can perform a complete hot and cold shower routine again or a partial one just applying the water directly to or near the area where there is a bone fracture. While you are doing both hot and cold showers, pay special attention to any affected area and massage it as vigorously as is safe and comfortable. If a shower is impossible, then alternate hot packs and ice packs on the area of the bone fracture.

BONE FRACTURES – CONCLUSION

By following the recommendations and suggested supplement schedule, healing time for bone fractures can be significantly reduced and fractures may heal more completely with fewer complications. By ensuring your body receives the proper nutrients it needs to heal itself, and by engaging in other relevant practices (e.g., hydrotherapy), you and/or your loved ones may be able to deal with bone fractures successfully, and continue a healthy, vibrant lifestyle.

ADDITIONAL RESOURCES

HPDI REJUVENATION PROGRAM

REJUVENATION PROGRAM PART 6 (INCLUDES HYDROTHERAPY)

REJUVENATE!™ SUPERFOODS

ULTIMATE PROTECTOR™

“FRED’S FAVORITE VEGETABLE JUICE RECIPE: ‘THE DOCTOR'”

2

THE NEED FOR IODINE SUPPLEMENTATION

Dr. Hank Liers PhD iodine supplementationFred Liers PhD iodine supplementationThe Orthomolecular Medicine News Service (OMNS) published on June 12 “The Need for Iodine Supplementation.” We believe strongly in the need for iodine supplementation, especially given the fact that more than 90% of the US population is iodine deficient. For this reason we make available both Nascent Iodine and Lugol’s Iodine Solution 2 to our customers.

We present the full OMNS article (below), as a source of valuable information to our resellers and Creating Health Naturally readers. The factors contributing to massive-scale iodine deficiency remain virtually unchanged over decades. This has led to a greater need for educating health professionals and individuals about the critical importance of iodine supplementation.

Another useful article discussing the benefits of iodine supplementation was published August 2 by Dr. Mark Sircus, OMD: “Iodine, Thyroid and Low Body Temperature.” ~

The Need for Iodine Supplementation

by Wojciech Rychlik, PhD

(OMNS, June 12, 2017) Feeling tired, having low energy or depression, gaining weight, memory problems, having dry skin, dry mouth, or immune system issues? There is good chance your body needs iodine supplementation. Why iodine? Because this essential to human health element has been singled out as dangerous, for several obscure reasons, and it has been gradually eliminated from our diet, and even worse, replaced by its antagonist, bromine. This trend has been termed, iodophobia (1). It is a cause of widely occurring hypothyroidism in many developed countries.

Iodine: How Much?

Iodine deficiency is associated with (2, 3, 4):

  • Fibrocystic breast disease leading to breast cancer and stomach cancer
  • Goiter (enlarged thyroid)
  • Mental issues from reduced alertness, lowered IQ, autism to cretinism, lack of iodine for the fetus leads to cretinism, and in milder cases to autism and ADHD
  • Slow metabolism, leading to tiredness, sluggishness, fatigue, apathy, depression, and insomnia
  • Inability to produce saliva, dry skin, and lack of sweating
  • Lack of optimal detoxification, especially of bromides, fluorides, and heavy metals
  • Sensitivity to temperature changes, and cold hands and feet
  • Muscle pain, fibrosis, and fibromyalgia
  • Erectile dysfunction, infertility and miscarriages, and low sex drive
  • Overweight
  • High blood pressure, and increased incidence of heart attacks and strokes

The Food and Agriculture Organization (FAO) of the United Nations has published probable safe upper limits for dietary intake of iodine (5). They range from 150 micrograms (mcg) per kilogram (kg) per day in newborn infants to 30mcg/kg/day in adults. That is 2 milligrams (2,000 micrograms) daily for a 146-pound adult. The safe upper limit is higher during pregnancy and lactation (40 mcg/kg/day).

Treatments for Hypothyroidism

The simplest method to deal with an underactive thyroid is proper supplementation with iodine, called orthoiodosupplementation. If the thyroid is damaged, then supplementation with thyroid hormones, thyroxine (T4) and triiodothyronine (T3, the main biologically active hormone) may be necessary. Supplementation (6). with these hormones should be done under close supervision of a medical professional. However, supplementation with inorganic iodine is generally much safer, as the body “knows” how much T4 and T3 need to make. There are also drugs that change physiology of iodine metabolism, but this subject is beyond the scope of this article. Pharmaceutical companies pressure doctors to avoid inexpensive orthoiodosupplementation, so you won’t likely get a prescription for inexpensive Lugol’s solution from a mainstream practitioner.

One caveat to supplementation with iodine is the autoimmune illness called Hashimoto’s disease, or chronic lymphocytic thyroiditis, which is one of the potential causes of hypothyroidism. Unfortunately, when hypothyroidism is diagnosed, the possibility that Hashimoto’s disease underlies this condition has not always been properly tested. Therefore, Hashimoto’s disease has often been misdiagnosed. Doctors usually treat this condition with hormone replacement therapy, and some believe that excessive iodine intake may trigger it in susceptible people (7). Always ask your doctor if iodine supplements are right for you.

History of Iodine Usage and “Iodophobia”

This subject has been covered in detail by Dr. Guy E. Abraham (8,9,10). The iodine element was discovered in 1811 by B. Courtois. In 1850–1853 A. Chatin noted that goiter and cretinism are rare in geological zones rich in iodine and frequent where iodine is in short supply, and that goiter can be prevented by iodine supplementation. In 1895 E. Baumann proposed that iodine is the active element in the thyroid gland.

By the time Bauman identified large concentrations of iodine in the thyroid gland in 1895, pharmaceutical and apothecary preparations containing iodine, excluding thyroid extracts, were widely used as a panacea.

To quote Kelley: (11) “The variety of diseases for which iodine was prescribed in the early years is astonishing – paralysis, chorea, scrofula, lacrimal fistula, deafness, distortions of the spine, hip-joint disease, syphilis, acute inflammation, gout, gangrene, dropsy, carbuncles, whitlow, chilblains, burns, scalds, lupus, croup, catarrh, asthma, ulcers, and bronchitis – to mention only a few. Indeed, tincture of iodine, iodoform, or one of the iodides, was applied to almost every case that resisted the ordinary routine of practice; and between 1820 and 1840 there appeared a remarkable series of essays and monographs testifying to the extraordinary benefits to be achieved by this new and potent remedy.”

Unfortunately, these monographs have virtually disappeared from US medical libraries. In the mid-1800s, iodine treatments of some diseases called for ingestion of gram (1,000 mg) amounts per day. However, most treatments were from 5 to 50 mg daily. The recommended daily amount of iodine by Dr. G. E. Abraham is 0.1-0.3 ml Lugol containing 12.5-37.5 mg elemental iodine. This is the amount of iodine needed for whole body sufficiency, based on a recently reported iodine/iodide-loading test (12). Thyroid gland sufficiency for iodide is achieved with a lower dose.

Lugol's iodine supplementation

The first iodophobic authority emerged in early 1900s. Prof. T. Kochler reported that he suffered from overactive thyroid following ingestion of iodide (just a single individual case, not a statistical research study!) Despite this, the number of applications grew. In an International Index published in 1956, and devoted exclusively to iodine pharmaceuticals, no less than 1,700 approved iodine-containing products were listed. In 1948 Wolff and Chaikoff published that a serum inorganic iodide level at a concentration of 1 µM blocks (one micromolar) the synthesis of thyroid hormones, resulting in hypothyroidism and goiter in rats. But this conclusion was erroneous as they even did not measure thyroid hormones in the rats studied, and of course, hypothyroidism and goiter were not observed in those rats. Many organic forms of iodinated drugs were quite poisonous. Unfortunately, medical establishment did not make a distinction between organic and inorganic forms of iodine, and iodophobia became more popular.

Decades ago, iodine was added to bread so that one slice contained 150 mcg of iodine (the current recommended daily allowance). In the 1980s, bromine replaced iodine in bread. Since bromide is an antagonist to iodine (it is goitrogenic), it worsened iodine deficiency in the US. Moreover, a big push to remove salt from our diet (the only grocery item still supplemented with iodine) exacerbated the problem. The only developed nation that resisted iodophobia is Japan, statistically the healthiest and longest living nation on the planet. Their average daily consumption of iodine is around 5 mg, with various reports ranging from 1 mg to 18 mg. In a study of reported daily iodine intake versus total number of clinical symptoms, an intake of approximately 1 mg per day correlated with the lowest number of reported symptoms, that is, the highest level of health (13). Recent popularization of bromides in our food supplies likely increased this amount.

According to Dr. Abraham, (14) “proper amounts of iodine in the food supply should be considered one of a nation’s greatest assets. Removing iodine from the food supply is a major mistake. Supplying a daily intake of iodine sufficient for the whole body (100-400 times the RDA) gives protection against goitrogens and radioactive iodine/iodide fallout; improves immune functions, resulting in an adequate defense system against infection; decreases singlet oxygen formation which is the major cause of oxidative damage to DNA and macromolecules, resulting in an anticarcinogenic effect in every organ; results in a detoxifying effect by increasing urinary excretion of the toxic metals lead, mercury, cadmium, and aluminum, as well as the goitrogens fluoride and bromide; normalizes hormone receptor functions resulting in improved response to thyroid hormones both endogenous and exogenous; and results in better control of blood sugar in diabetic patients; stabilizes cardiac rhythm, obviating the need for the toxic sustained release form of iodine, amiodarone; and normalizes blood pressure without medication in hypertensive patients. Iodine deficiency is the major cause of cognitive impairment, worldwide.”

The Iodine-Cancer Connection

The body requires iodine to metabolize both omega-3 and omega-6 fatty acids. A substance called delta-iodolactone, a derivative of arachidonic acid, which is produced in the thyroid gland and breast tissue, prostate, colon, and the nervous system, is a regulator of a process called cellular apoptosis (“cell death”). Ascorbic acid is required to stimulate intracellular hydrogen peroxide synthesis that, in turn, provides the energy to make iodine free radicals necessary for this reaction. When the level of delta-iodolactone is high enough, the process of apoptosis can then kill cancer cells. (15)

Unfortunately, the recommended daily allowance (RDA) for iodine — about 150 mcg per day — will not allow delta-iodolactone to be efficiently formed in the thyroid gland. The thyroid requires higher iodine concentrations to efficiently produce it. Researchers have found that 100 times the RDA amount of iodine is optimal to produce delta-iodolactone. That equates to taking about 15 mg of iodine per day (15,16). These findings are important because they imply that there are some biochemical reactions that require much larger amounts of iodine than the current RDA. The mechanism by which delta-iodolactone induces cell death may be an important pathway for curing some types of cancer.

Forms of Iodine

Inorganic iodine exists in 6 oxidative states, from -1 to +7. The most reduced form (with most electrons) is iodide (I); an example is potassium iodide. The diatomic form of elemental iodine I2, has no electrical charge. Monoatomic iodine also has no electrical charge, but is unstable and highly reactive (free radical, labeled as an I with a dot, I* ). It can be produced by exposing I2 to ultraviolet light. Electric and magnetic fields won’t do it, as is sometimes incorrectly suggested. More oxidized forms of iodine are: hypoiodite (I+1), iodite (I+3), iodate (I+5), and periodate (I+7). The body’s metabolism may convert (reduce) these forms to biochemically available iodide, but at the cost of depleting its antioxidants. All forms of positively charged iodine are relatively poisonous, with established lethal doses (LD50) in the range of 35 to 2100 mg/kg. Elemental iodine (I2) and iodides (I) are non-poisonous. However, a bad “antiseptic” non-culinary taste of iodine (I2) suggests to our senses that this is not so good choice for supplementation.Nascent iodine supplementation

Despite that adverse taste, almost all the research on iodine supplementation has been done using Lugol’s Solution (17). The original solution is called 5% Lugol’s Iodine, but in reality it consists of 12.5% iodide/iodine or (I/[I3]) ions. Two drops of Lugol’s Solution (0.1 ml) contain 12.5 mg iodine/iodide mix. Iodine tablets that are a solid form of Lugol’s solution, were created to mask the taste and make the doses more precise for dietary supplementation.

I should mention a few points about Edgar Cayce’s atomidine. This famous visionary wrote several articles about the best form of iodine supplement (18). Some claim that this was iodine trichloride, but that cannot be true as this compound is toxic by ingestion and damaging to mucous membranes. It decomposes to ICl and poisonous gas Cl2 at 77 degrees C and also in water at room temperature (19). Most likely Cayce’s atomidine was simply a 1% iodine solution (I2) in 95% ethanol. I am surprised that there are educated people, even medical doctors who claim that “elemental monoatomic iodine” preparations (Atomidine, Nascent Iodine etc.) are the best forms of iodine supplements. May be it has something to do with efficient marketing? Elemental Iodine (I2) is soluble in glycerin. Replacement of ethanol with glycerol indeed makes these supplements more consumption-friendly, so they are sold by some vendors as superior products to Cayce’s ethanol-formulated one. Personally, I think glycerol-based I2 supplements are inferior to iodides; however, they are excellent antiseptics.

To defend the validity of Cayce’s vision, in thyroid, I ion and amino acid tyrosine react through a short intermediate step by forming monoatomic I* free radical (selenium and hydrogen peroxide are involved) to make monoiodotyrosine. Diiodotyrosine is formed analogical way, and finally, two of these molecules combine to produce thyroxine. All those steps are carried by the enzyme thyroid peroxidase, which is normally attached to the protein thyroglobulin. So, yes, monoatomic iodine I* exists in human bodies, and it directly reacts with tyrosine, but no, it wouldn’t be healthy to consume iodine free radicals as their high reactivity would prevent safe transport throughout the body.

In the mid-1930s the thyroid hormone thyroxine became available on the market. This was a blessing for people who had damaged their thyroid. Unfortunately, doctors started to prescribe this hormone to just about anybody with hypothyroidism, thinking that they can control better thyroid hormone levels than our bodies can. And, the “iodine is iodine, no matter what form” mentality became a dangerous trend, because most medical professionals do not fully appreciate the difference between the raw nutrient (iodine) and its product (hormone).

The pharmaceutical industry came up with lots of organic forms of iodine (NB: organic, meaning that iodine is bound to a carbon-atom-containing molecule and NOT meaning it’s grown in a pesticide-free environment), all relatively toxic and certainly not to be used without strict medical supervision. Only inorganic forms of iodine, I and I2, are safe for supplementation (20,21). Further, high doses of these supplements should still be supervised by your doctor.

Iodine Uses

Iodine plays critical role in human metabolism. Many researchers believe the RDA value of 150 mcg for iodine is too low, especially when this element is commonly substituted with competing element bromine. Therefore, the main use of iodine in dietary supplementation is to enable optimal thyroid function. There are a number of medical conditions where iodine is either essential or helpful. For best results, iodine/iodide should be supplemented with selenium, magnesium, copper (there is usually enough of it in tap water as copper is widely used in plumbing), vitamin B2 (riboflavin) and B3 (niacin). Ask your doctor before taking any iodine supplements, especially if you are on medications.

Elemental iodine (I2) is antibacterial and antifungal, so iodine or iodine/iodide solutions are commonly used topically to sterilize wounds, or internally to fight infections, such as vaginitis and sore throat, and also to sanitize drinking water. Because iodine is antibacterial, drinking it may cause friendly bacterial flora to suffer and result in diarrhea and stomach cramps (the same applies to Lugol’s solution, but to a lesser extent as it contains iodides as well).

Ingestion of iodides prevents the incorporation of destructive radioactive iodine into the body (mainly by the thyroid) in case of nuclear accidents. It also may help flushing already incorporated radioactive iodine from the thyroid, although too much iodine inhibits secretion of T4/T3 from the gland.

Common-Sense Cautions

Overdosing any of the iodine supplements can lead to swollen salivary glands, metallic aftertaste and skin rash and itching (that are usually due to rapid process of detoxification from heavy metals fluorides and bromides), faster heartbeat or palpitations and diarrhea. When supplementation is stopped, these symptoms will usually disappear quickly, often within one day. Iodine stabilizes thyroid hormone production, so it is an adaptogen, but in rare cases, such as acquired allergy to iodine (Hashimoto’s disease), it may actually misbalance it. In some cases, iodine supplementation can cause hypothyroidism, so it’s important to get checked by your doctor to make sure that your thyroid function is not worsened by supplementation. Some authors advising caution are Alan Christianson (22), Jeffrey Dach, (23) and Alan Gaby (24). Testing of levels of thyroid hormones along with testing and supplementation of mineral nutrients such as selenium, zinc, copper, magnesium calcium, and other trace minerals may prevent problems in cases where high doses of iodine/iodide might tend to cause Hashimoto’s disease. (23)

Inorganic Iodine Availability

The most common form of iodine supplement is Lugol’s solution (17). The original solution contains 5% of iodine and 10% iodide. Solid pill forms of Lugol’s solution are sold under several brand names. Potassium iodide (KI), my favorite iodine supplement, is available as tablets as well. Various products with kelp or other seaweed extracts contain iodides as well. Check the label when you buy as some of them are very diluted.

It is difficult to find inexpensive elemental iodine (I2) solution in alcohol. You can buy iodine crystals online and make the proper solution by yourself very easily (using either alcohol or glycerol). The monoatomic iodine concept is simply a marketing gimmick that has been created to inflate the price several fold. Note that if the monoatomic claims were really true, few would really want to drink free radicals, the only monoatomic form that exists. Iodine free radicals are not transported freely in our bodies because they are too reactive. Elemental iodine preparations, including iodine dissolved in glycerol, may be helpful products for external antiseptic use rather than a supplement.

Another form of iodine supplement includes a mixture of algae and thyroid extract in glycerin, water and ethanol. This is likely not harmful because it contains T3 and T4 only in very small amounts, and the recommended serving size is also small. Other complex formulae that contain elemental iodine are a useful antiseptic, but not a good supplement. Iodine trichloride should be avoided as a supplement because it is too toxic.(19)

Summary

The established RDA allowance for iodine (150 mcg/day) is inadequate for many individuals. In order to maintain optimum health, adults need 2-5 mg of iodide daily. Actually, this is in line with the upper safe limit of dietary intake of iodine established by FAO (30 mcg/kg/day). In case of a dysfunctional thyroid or other illnesses, such as fibrocystic breast disease or cancer, 15-50 mg daily may be needed. Ask your doctor about the alternatives to hormone therapy or taking iodine-containing organic drugs, because inexpensive orthoiodosupplementation would usually not be his/her first choice.

The best and safest form of iodine supplementation for a healthy adult is iodide. Iodides are naturally produced in larger quantities by various seaweeds.

Please consult your doctor about iodine supplementation, as in your particular case it may be contraindicated.

References:

1. Abraham GE. The History of Iodine in Medicine Part III: Thyroid Fixation and Medical Iodophobia. http://optimox.com/pics/Iodine/IOD-16/PUB_16.htm

2. Dommisse J. MD Best Kept Secret (2009) http://www.westonaprice.org/modern-diseases/best-kept-secret/#sthash.vdrKPaJw.dpuf

3. http://theiodineproject.webs.com/addadhdautism.htm

4. Hamza RT1, Hewedi DH, Sallam MT. (2013) Iodine deficiency in Egyptian autistic children and their mothers: relation to disease severity. Arch Med Res. 44(7):555-61. http://www.ncbi.nlm.nih.gov/pubmed/24120386

5. http://www.fao.org/docrep/004/y2809e/y2809e0i.htm

6. Abraham GE. The Concept of Orthoiodosupplementation and Its Clinical Implications. https://www.optimox.com/pics/Iodine/IOD-06/IOD_06.htm

7. http://www.webmd.com/women/hashimotos-thyroiditis-symptoms-causes-treatments#1

8. Abraham GE. The History of Iodine in Medicine Part I: From Discovery to Essentiality. http://optimox.com/pics/Iodine/IOD-14/PUB_14.htm

9. Abraham GE. The historical background of the Iodine Project. http://www.optimox.com/pics/Iodine/IOD-08/IOD_08.htm

10. Abraham GE. The History of Iodine in Medicine Part II: The Search for and the Discovery of Thyroid Hormones. http://optimox.com/pics/Iodine/IOD-15/PUB_15.htm

11. Kelly FC. “Iodine in medicine and pharmacy since its discovery , 1811-1961.” Proc R Soc Med, 1961; 54:831-836. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1869599/

12. Abraham GE. “The safe and effective implementation of orthoiodosupplementation in medical practice.” The Original Internist, 2004; 11(1):17-36. http://www.hakalalabs.com/Research/Abraham_OI_Mar04.pdf

13. Fallon Morell S. The Great Iodine Debate (2009) The WestonA. Price Foundation, http://www.westonaprice.org/modern-diseases/the-great-iodine-debate/

14. Abraham GE. The Wolff-Chaikoff Effect: Crying Wolf? https://www.optimox.com/pics/Iodine/IOD-04/IOD_04.html

15. Brownstein D. The Cancer-Iodine Connection, (2015) http://www.newsmax.com/Health/Dr-Brownstein/iodine-cancer-cell-death-fish-oil/2015/06/10/id/649877/

16. 6-Iodolactone, key mediator of antitumoral properties of iodine, M. Nava-Villalba, C. Aceves, (2014) Prostaglandins & Other Lipid Mediators 112, 27-33. https://www.researchgate.net/publication/263856609_6-Iodolactone_key_mediator_of_antitumoral_properties_of_iodine

17. Bacteriological Analytical Manual, R40 Lugol’s Iodine Solution (2001), http://www.fda.gov/Food/FoodScienceResearch/LaboratoryMethods/ucm062245.htm

18. Review of Atomidine, International Wellness Directory, http://www.mnwelldir.org/docs/reviews/atomidine.htm

19. Material safety data sheet, http://www.mnwelldir.org/docs/history/Iodine_Trichloride.pdf

20. Abraham GE. The historical background of the Iodine Project http://www.optimox.com/pics/Iodine/IOD-08/IOD_08.htm

21. Abraham GE and Brownstein D. A Rebuttal of Dr. Gaby’s Editorial on Iodine. (2005) Townsend Letter, The Examiner of Alternative Medicine, http://www.townsendletter.com/Oct2005/gabyrebuttal1005.htm

22. Christianson A. http://www.integrativehealthcare.com/why-i-discourage-high-dose-iodine/

23. Dach J. http://jeffreydachmd.com/iodine_is_safe

24. Gaby A. http://www.townsendletter.com/AugSept2005/gabyiodine0805.htm

Nutritional Medicine is Orthomolecular Medicine

Orthomolecular medicine uses safe, effective nutritional therapy to fight illness. For more information: http://www.orthomolecular.org

Access the original OMNS article, “The Need for Iodine Supplementation”: http://www.orthomolecular.org/resources/omns/v13n14.shtml

OMNS free subscription: http://orthomolecular.org/subscribe.html

OMNS article archive: http://orthomolecular.org/resources/omns/index.shtml

2

QUICKSILVER LIPOSOMAL FORMULAS – NEW PRODUCTS!

Fred Liers PhD quicksilver liposomal formulasOne of the most significant developments for nutrient uptake and assimilation is the advent of liposomal delivery systems. Once in the range of 300–5,000 nanometers, the latest liposomes are now just 20–100 nanometers (nm)!

The significance of these small liposomes—tiny bilayer lipid structures—is that there is a major increase in the amount of nutrient delivery to cells. That is, small liposomes show significantly greater efficiency at intracellular delivery of encapsulated compounds.

Liposomal delivery systems have evolved rapidly and now offer major advantages over nutritional supplements delivered by standard means—like capsules, tablets, powders, and liquids (e.g., tinctures).

Liposomal delivery systems first utilized multi-lamellar vesicles (MLV) ranging ins size from 300–5,000 nanometers. Later, “large” unilamellar vesicles (LUV) (100–300 nanometers) were developed. Products containing LUVs are more effectively assimilated than MLVs.

As noted, lipsomal technologies have shrunk liposome sizes to 20–100 nanometers (nm), the category size for small unilamellar vesicles (SUV). This means the body can far more easily assimilate nutrients delivered liposomally when the particle sizes are up to 10 times smaller than already effective liposome sizes.

Small liposomes (SUV) have a long circulation half-life and better cellular accumulation. Small lipid particles have the fastest uptake kinetics and can participate in paracellular (between cells) transport. The nutritional liposome industry is rapidly moving toward the use of small liposomes.

Key Point: Small liposomes (SUV) are significantly more efficient at intracellular delivery of encapsulated compounds. In a recent study with carefully sized liposomes, cellular uptake increased nine-fold as liposome size was decreased from 236 nm to 97 nm and was 34 fold higher at 64 nm.

Nutrients that can be delivered liposomally range from vitamin C and glutathione to many types of adaptogenic and medicinal herbs.

Benefits of Liposomal Delivery

  • Rapid update, assimilation, and movement into cells
  • Oral intake bypasses digestive system—nutrients go directly into body
  • High levels of nutrients assimilated
  • Reduced dosages and less “wasted” product
  • Nutrients penetrate smallest compartments in the body
  • Nutrients circulate widely
  • Precise intra-oral delivery
  • Simple manual pump from glass bottle
  • Easy water dispersability when desired
  • Good tasting!

Liposomal delivery systems are the future of nutritional supplements given all the advantages they confer. HPDI recognizes the value of liposomal products, and now offers the best formulas available—from Quicksilver Scientific, Inc.—to our customers.

QUICKSILVER LIPOSOMAL FORMULAS

HPDI offers four liposomal formulas from Quicksilver Scientific, the leader in nanoliposomal delivery systems. Each formula offers unparalleled uptake and assimilation—and good taste!—via inta-oral delivery. These products include:

Quicksilver liposomal formulas

HPDI offers four liposomal formulas from Quicksilver Scientific.

Liposomal Vitamin C with R-Lipoic Acid (mean size 50–100nm): Quicksilver Scientific’s Etheric Delivery™ system for Liposomal Vitamin C (with R-Lipoic Acid) is the most absorbable form of professional-grade Vitamin C. Vitamin C is essential to any detoxification program because it feeds the system that eliminates toxins. It is also very effective in removing lead and other heavy metals from our system and fighting off the free radicals that form in the liver during the first phase of detoxification.

R-Lipoic Acid (as sodium R-Lipoate) has an exceptionally well-documented ability to upregulate the glutathione system via the Nrf2 nuclear transcription pathway. This combination of liposomal vitamin C and R-Lipoate in a nanoliposomal delivery system potently harnesses the potential of Vitamin C to the power of a fully functioning glutathione system.

The absorption of conventional oral Vitamin C diminishes rapidly as the dose increases (e.g., about 19% for 1000 mg oral vitamin C). Nanosphere delivery greatly increases absorption and for some compounds can provide higher intracellular delivery than an IV administration.

Quicksilver Vitamin C

Quicksilver Liposomal Vitamin C with R-Lipoic Acid

Suggested Usage: General use for antioxidant and detoxification function, take eight pumps per day (1,000 mg of Vitamin C and 50 mg of R-Lipoate). For advanced intermittent use, use up to 50 pumps per day (6,250 mg Vitamin C and 312.5 mg R-Lipoate) or more, in divided doses throughout the day. For detoxification protocols, especially with metal toxicities, build dosage gradually, starting from low doses, as they are tolerated. If strong detoxification reactions are observed, back off dosage. Children should start at approximately 1/4 of adult (two pumps per day) dosage and work up. For topical application, one pump can cover the face for a daily treatment, or use several pumps as a mask and leave on for 10–15 minutes; skin can be re-wetted and left for another 10 minutes before rinsing off excess.

Liposomal Glutathione: Quicksilver’s Phospholipid Encapsulation Etheric Delivery system protects glutathione from digestive enzymes that otherwise inhibit absorption of oral glutathione supplementation. In cell cultures, liposomal products have demonstrated over 100 times more efficiency for intracellular delivery than IV-based liposomal glutathione.

Quicksilver’s Liposomal Glutathione comes with a precision pump to accurately deliver 50 mg of reduced glutathione and 68 mg of injectable-grade essential phospholipids (derived from sunflower oil) per pump. The patent-pending process, plus a natural lemon flavoring, allows this product to be taken intra-orally for maximum absorption without the foul sulfur taste typical of liposomal glutathione products. The formula can be taken every 3–4 hours for even delivery throughout the day. One bottle delivers 100, 0.5 ml doses.

Quicksilver Liposomal Glutathione

Quicksilver Liposomal Glutathione with Lemon Mint

Suggested Usage: For general antioxidant and detoxification protection, use eight pumps per day (400 mg glutathione). For advanced protection, use up to 20 per day (1,000 mg glutathione) or more, in divided doses throughout the day. For large doses, take two pumps at a time to allow for maximum oral absorption, and hold at least 30 seconds before swallowing. Children should start at approximately 1/4 of adult (two pumps per day) dosage and work up.

Liposomal Colorado Hemp Oil: This product uses non-THC (<0.3%) cannabidiol (CBD) from all-natural Colorado Hemp Oil. CBD is the non-psychoactive part of the industrial hemp plant. Quicksilver Scientific’s liposomal delivery of Nanoemulsified Colorado Hemp Oil far outpaces tinctures and is faster, stronger and more effective. Cannabidiol interacts with our body’s naturally occurring cannabinoid receptors to aid with pain relief and enhanced feelings of well being. The advanced technology behind this groundbreaking liquid delivery method makes for precise dosing and immediate effect.

Because of the known interaction of CBD with these cannabidiol receptors, much new research has focused on CBD’s receptor-mediated neuro-protective, antiemetic, and analgesic properties, and of its effect on mood and other aspects of mental health.

New research on gene transcription modulation offers an even deeper look into the biochemical mechanisms at work when ingesting CBD. Research in this vein has shown more than 1,000 genes that are differentially upregulated by CBD (a more than ten-fold increase than those affected by THC). In general, the effects increased cell stress responses—including antioxidant-defense and detoxification genes (mainly via EhRE/ARE-Nrf2 induction)—and downregulated many inflammation-mediating genes. These effects combined with CBDs NMDA-receptor-stabilizing effects, show great promise for its use in calming the neuro-inflammatory responses accompanying neurotoxic and chronic illness states.

Quicksilver Nanoemulsified Colorado Hemp Oil

Nanoemulsified Colorado Hemp Oil

Suggested Use: Take 1–4 pumps by mouth, holding for 30 seconds before swallowing. Repeat if needed. Four pumps contain 30 mg of Hemp Extract (aerial parts) and 12 mg of Phytocannabinoid Diols. There are 25 four-pump servings per container. Best taken on an empty stomach 10 minutes before meals. May be stirred into a small amount of water. Once opened, use within 60 days. Store at room temperature and away from light.

Liposomal NanoMojo (adaptogenic blend): Dr. Christopher Shade, PhD of Quicksilver Scientific, collaborated with master herbalist Dan Moriarty of Sun Horse Energy to create NanoMojo, a groundbreaking functional medicine product. By combining Moriarty’s unique adaptogenic formulation with Dr. Shade’s state-of-the-art liposomal encapsulation, they’ve overcome the limitations of poor oral adsorption and made the phytochemicals quickly available at the cellular level. This new innovative blend of adaptogens from around the world is maximized for effectiveness.

Adaptogens are non-toxic phytochemicals that help the body achieve homeostatic balance under adverse conditions that would typically be associated with sympathetic (fight or flight) reactions. They help regulate natural harmony, adrenal balance, and stress accommodation (resistance to stress). In fact, adaptogenic herbs have been used in Ayurvedic medicine for more than 4,000 years and Chinese medicine for nearly 3,000 years to increase energy (chi) and concentration.

Scientific literature reports that adaptogenic herbs play significant roles in decreasing markers of stress-activated protein kinases, cortisol, and nitric oxide. These markers indicate a lowered level of systemic stress and inflammation and decreased symptoms of an over-taxed adrenal system.

NanoMojo contains the following adaptogenic herbs: Açaí, Lyceum (Goji) fruit, Gynostemma (Jiaogulan) (aerial parts), American Ginseng (root), Siberian Ginseng (root), Schisandra (fruit), Licorice (root), Rhodiola (root), Astragalus (root), Reishi (fruiting body), Catuaba (bark), Stinging Nettle (aerial parts), Saw Palmetto (fruit), Guarana (seed), Ashwagandha (root), Tribulus (aerial parts), Epimedium (aerial parts), Yohimbe (bark), and Organic Maple (sap) syrup.

NanoMojo helps your body adapt to the various conditions that cause stress, something most of us experience daily. This liposomal formulation is the culmination of more than eight years of research and development. Not only is it effective, but it also tastes very good.

Quicksilver liposomal NanoMojo adaptogens

NanoMojo Liposomal Adaptogenic Blend

Directions: Take two pumps twice daily, or more. May be mixed into a small amount of water. Best taken on an empty stomach. Once opened, use within 60 days.

CONCLUSION

The advent of small liposomes means significantly greater uptake and assimilation of nutrients than ever before. This means you stand to benefit greatly from advanced intra-orally delivered nanoliposomal formulas like those developed by Quicksilver Scientific, Inc.

 

 

SOURCES & RESOURCES

ARTICLES

Recent Advances in Liposome Technology (HPDI blog)

PRODUCTS

Quicksilver Scientific Liposomal Formulas (HPDI website)

Liposomal Vitamin C with R-Lipoic Acid

Liposomal Glutathione with Lemon Mint

Nanoemulsified Colorado Hemp Oil

NanoMojo Liposomal Adaptogenic Blend

 

HOMOCYSTEINE GENETICS – COENZYME B VITAMINS

Dr. Hank Liers, PhD homocysteine coenzyme B vitaminsWe previously published an article titled FOLATE INGREDIENTS – FOLINIC ACID & 5-MTHF in which we discuss how coenzyme folate vitamins are far superior to the synthetic folic acid form. In today’s article, I take a more in-depth look at how homocysteine is formed from methionine, how genetics affects the metabolic pathways, and how B vitamins are used in metabolic pathways.

One way to look at the metabolic pathways of methionine (an essential amino acid) is that it provides a way for the body to convert this sulfur containing amino acid either to cysteine and its key by-products glutathione, taurine, and sulfates or allows remethylation back to methionine to occur using either the Folate Cycle or the Trimethyl glycine (betaine) pathways.

Figure 1 shows these metabolic pathways including the vitamins required at each step including vitamin B6 (as P-5-P), methylcobalamin, and 5-methyltetrahydrofolate (5-MTHF). In addition, it shows the key enzymes produced by the body at each step. These enzymes include CBS (cystathione beta synthase), BHMT (betaine homocysteine methyltransferase), MS (methionine synthase), and MTHFR (methylene tetrahydrofolate reductase).

homocysteine metabolism diagram

Figure 1. Metabolic Pathways in Methionine and Homocysteine Metabolism

HEALTH ISSUES ASSOCIATED WITH HIGH HOMOCYSTEINE LEVELS

It is highly important that the various metabolic pathways function correctly to keep homocysteine at healthy levels (6–8 µmol/L). Unfortunately, high levels of homocysteine in the body (10–20 µmol/L) are a factor in a wide range of health issues, including:

  • Greater risk for heart problems, including coronary artery disease, heart attacks, stroke, high blood pressure, congestive heart failure, and abnormal cholesterol levels. This is due to increased inflammation, sometimes due to blood clotting spontaneously, and because of blockages of the major arteries.
  • Mental abnormalities such as depression, anxiety, bipolar disorder, and other mental problems are more common among people with high homocysteine
  • Migraines and headaches in a significant percentage of the population
  • In those who suffer from high homocysteine due to having nutritional deficiencies anemia, aches and pains, hearing loss, age-related macular degeneration (ARMD), slowed development, and birth defects might also be possible
  • Greater risk for dementia, Alzheimer’s disease, brain atrophy, and other cognitive problems
  • In children, skeletal and developmental abnormalities including having a curved spine or protruding chest and rib cage. Some patients appear very tall and thin, and some might also have very long, thin “spider-like” toes and fingers.
  • Behavioral problems, including ADHD, autism and other learning disabilities

ROLE OF GENETICS IN HOMOCYSTEINE METABOLISM

Ten or more years ago, questions of how genetics enters into homocysteine metabolism were unlikely to be asked. However, in recent years DNA testing has advanced and is now available to everyone (for example, see my article about Bodysync’s genetic test, DISCOVERING NUTRITIONAL NEEDS THROUGH ADVANCED GENETIC TESTING.

You may have heard a great deal about MTHFR (methylene tetrahydrofolate reductase). This gene is involved in folate metabolism and has a central role in methylation processes like repair of and building new DNA in dividing cells.

In the remethylation pathway for conversion of homocysteine to methionine, MTHFR plays a key role in converting folate into 5-MTHF which is needed along with B12 as methylcobalamin in order for the conversion to take place. Genetic variations in MTHFR have been studied in depth. Of the many variations studies the most significant ones appear to be variations of C677C such as C677T (referred to as heterozygous) or T677T (referred to as homozygous). The heterozygous variant appears in about 30–50% of the population and causes somewhat less efficiency in the conversion of folic acid to 5-MTHF. However, the homozygous variation occurs in about 10% of the population and can have serious effects due to converting little homocysteine back to methionine.

Another variation in MTHFR is called A1298A. These variations are A1298C and C1298C and will have similar effects to the C677C variations. It was interesting to me when I recently analyzed my Bodysync genetic test results showing I carry the variation A1298C (heterozygous), which indicates I may not be effectively converting homocysteine back to methionine.

Additionally, my Bodysync genetic test results also indicate that I have heterozygous variations in the CBS enzyme shown in Figure 1, as well as heterozygous variations in MTR and MTRR enzymes, which are involved with B12 levels in the remethylation pathway. These results indicate that I need to take higher levels of methylcobalamin and 5-MTHF.

IMPORTANCE OF COENZYME FORMS AND PROPER AMOUNTS OF B VITAMINS

Many of the B vitamins on the market today unfortunately are in synthetic form. The body can only use the natural coenzyme forms effectively. For example, the body needs vitamin B6 in the form of P-5-P (pyridoxal-5-phosphate), folate in the form of L-5-MTHF, and B12 in the form of methylcobalamin for proper metabolism of methionine. In some cases the body can use the synthetic forms of pyridoxine HCl, folic acid, and cyanocobalamin but pays a cost (e.g., in time and energy) by having to convert synthetic forms to coenzyme forms.

Add to the prevalence of synthetic B vitamins, the fact that genetic deficiencies are more common than previously assumed, and it becomes clear that the coenzyme forms of B vitamins in the proper amounts are extremely important.

Fortunately, I have always believed it best to include as many coenzyme forms as possible in the nutritional supplements I formulate (over the past 27 years). For example, all HPDI multivitamins include coenzymes of B1, B2, B6, B12, and folate (as 5-MTHF and folinic acid). This is uncommon in most multivitamin formulas on the market. For this reason our supplements are ideally suited to the prevention or resolution of most genetic problems regarding homocysteine.

In addition, I have always chosen to include higher amounts than most multivitamins on the market. We also make available 5-MTHF one milligram (1 mg) capsules and methylcobalamin five milligram (5 mg) sublingual tablets. When genetic variations are in play as discussed above, then providing relatively higher amounts of coenzyme B vitamins that support important requirements in the body seems necessary.

Interestingly, several other nutrients are involved in the pathways involving methionine and homocysteine. These include zinc, magnesium, and Vitamin B2. Our multivitamin formulas and magnesium formulas, especially Myo-Mag with its coenzyme B1, B2, and B6, are recommended to support these nutrient needs. Finally, it has been found that N-Acetyl-L-Cysteine (NAC) can significantly lower homocysteine (by up to 50%), most likely because its gives the body an excellent source of cysteine without have to use methionine.

SUMMARY

In this article, I have shown the value of the use of genetic testing and high-quality coenzyme B vitamins in resolving health issues associated with high values of homocysteine in the body.

 

SOURCES & RESOURCES

DISCOVERING NUTRITIONAL NEEDS THROUGH ADVANCED GENETIC TESTING.

FOLATE INGREDIENTS – FOLINIC ACID & 5-MTHF

The Homocysteine Revolution by Kilmer S. McCully, MD

Role of hyperhomocysteinemia in endothelial dysfunction and atherothrombotic disease
(Cell Death and Differentiation 11, S56–S64)

PRODUCTS

5-MTHF
(coenzyme folate)

Methylcobalamin
(vitamin B12)

B-Complex-50

HPDI Multivitamins

0

GOT POTASSIUM?

Fred Liers PhD potassium minerals pH AdjustGot potassium? You heard me right. Po-tass-i-um.

Well, no—you probably don’t get enough—and you’re not alone. Fewer than 2% of people do.

Experts say 4,700 milligrams (4.7 grams) of potassium is the minimum daily intake required for health and to reduce risk of chronic disease.

Yet, the National Health and Nutrition Examination Survey (NHANES) reports the average potassium intake for Americans is 2,640 milligrams (2.6 g) daily. This low intake remains unchanged over decades! Most people get less than half the amount of potassium needed to meet “adequate” or minimum levels.

Given essential roles played by potassium in the body, and the known health benefits it confers, almost everyone — including you — can benefit from additional potassium. From where will it come?

That is to say, will the average person really meet recommended potassium intake from diet alone? I’m a huge advocate for increasing intake of dietary potassium, but long-term evidence suggests the answer is “no.” Supplementing with certain forms of potassium can be an effective adjunct to dietary intake.

It therefore can be highly beneficial to take a potassium-containing formula like pH Adjust, which provides potassium bicarbonate that boosts potassium levels and powerfully alkalinizes the body.

Bananas provide potassium (400–800 mg), but not if you don’t eat them!

THE “NEGLECTED” MINERAL?

For years, a parade of minerals—calcium, magnesium, zinc, iodine, and yes, sodium—have drawn attention from health professionals, consumers, and the media. Whither potassium?

Yet despite compelling scientific studies, articles, and books, potassium has not “caught on” among doctors, consumers, or health aficionados. Nevertheless, knowledgeable health professionals and a small number of health-consious individuals have known of its importance for decades and longer.

Potassium has become known as the “forgotten” or “neglected” mineral. It’s time to revisit what we thought we knew…or never knew. It’s time to recognize potassium as “first among equals” in the pantheon of macrominerals.

If you think you know potassium, prepare to think again.

POTASSIUM FACTS

A review from Nutrition 101…and some things you may not know:

The symbol for potassium is “K” in the periodic table. It is one of seven essential macrominerals including calcium, magnesium, phosphorus, sodium, chloride, and sulfur.

POTASSIUM BASICS:

• Regulates fluid balance in the body by means of the sodium-potassium pump (Na+/K+ pump)

• Controls electrical activity of cardiac muscle (heart) and other muscles

• Counters the effects of sodium and thereby maintains proper blood pressure

• Maintains proper acid-base balance in the body

BENEFITS OF HIGH (ADEQUATE) POTASSIUM:

• Decreases risk of dying from all causes (20%)

• Reduces risk of stroke

• Lowers blood pressure

• Protects against loss of muscle mass

• Preserves bone mineral density

• Reduces formation of kidney stones

POTASSIUM – NEEDED MORE THAN EVER?

Beyond the benefits you may take for granted that are provided by the mineral you don’t get enough of…there are many reasons why potassium is more important than ever.

One major reason potassium is needed more than ever: sodium.

Sodium is the essential macromineral no one seems to be lacking. Just the opposite! When people talk about sodium, it is usually about how to avoid it. Sodium is blamed for hypertension and adverse cardiovascular health. What is the connection between sodium and potassium?

It all starts at the level of the cell with the “sodium-potassium pump” (or N+/K+ pump). The sodium-potassium pump is responsible for keeping sodium out of cells and keeping potassium in. But it also a carrier for nutrients going into cells, and it is involved in the energy production.

The typical modern diet —low in potassium and high in sodium (and sugar)—is a major problem for cells because it compromises the function of the sodium-potassium pump. Optimal function of the sodium-potassium pump requires not only increasing potassium intake, but also reducing sodium intake.

Potassium Sodium Pump cell

The sodium-potassium pump expels 3 sodium ions and brings in 2 potassium ions per cycle

SODIUM – POTASSIUM RELATIONSHIP:

• Humans once consumed high levels of potassium (12 g or higher) and low levels of sodium (<2 g) daily. That 6:1 ratio in favor of potassium has radically shifted to a 2:1 or even 4:1 ratio in favor of sodium. Salt is everywhere in the food supply. The potassium to sodium ratio (K/Na ratio) is called the “K Factor.”

• High “K Factor”: During evolutionary history, humans consumed 5–10+ times more potassium than sodium. Because the prehistoric diet contained little sodium, the body developed means for conserving it through resorption. Conversely, our potassium supplies were higher, and therefore the body developed no system for conserving it—it is absorbed, filtered by the kidneys, and eliminated.

• Cellular imbalance between potassium and sodium can cause strokes and other damage without increasing blood pressure (K Factor xxix). An exclusive focus on decreasing blood pressure (whether through diet or drugs) that fails to take potassium into consideration may not produce desired results.

• The sodium-potassium (Na+/K+) pump is an important pump that exists in cells. Its job is to keep sodium levels low in cells (pump out sodium and wastes) and pump in potassium, glucose, and other nutrients. Sufficient potassium is critical for this all-important pump that keeps us healthy.

• When sodium (salt) levels are high and potassium levels are low, the pump does not function efficiently. Cells cannot prevent sodium from entering, causing them to swell from osmotic pressure, and causing metabolic blockage.

• The sodium-potassium pump uses sodium as a “carrier” to bring in potassium, glucose, and other nutrients. For every glucose molecule, two sodium molecules are pumped into a cell. With high sodium intakes, cells become overloaded with sodium, and the pump works far less efficiently.

• Low potassium creates greater imbalance preventing the pump from excreting sodium, and also preventing nutrients from entering cells. The cell produces less energy and enters a type of metabolic stasis.

• Studies show the greatest decreases in blood pressure occur not only when sodium intake decreases, but when potassium intake simultaneously increases.

The role of potassium in the sodium-potassium pump has implications for nearly every function in the human body. And potassium does a lot more.

MANY HEALTH BENEFITS

Potassium provides many benefits. These include known benefits for reducing hypertension, stroke, osteoporosis, and kidney stones, as well as supporting cardiovascular health, and stabilizing blood glucose. Many of potassium’s benefits relate to its role in the sodium-potassium pump. Other benefits relate to different aspects of potassium.

POTASSIUM ALKALINIZES YOUR BODY

Among the most significant features of potassium is its ability to alkalinize the body. Potassium neutralizes acids by itself and especially when combined with minerals such as bicarbonates.

I have recently posted several articles that discuss potassium’s role in keeping the body alkaline. Specifically, how consuming more potassium-rich fruits and vegetables remains the most important means for maintaining alkaline conditions in the body.

Potassium contributes mightily to acid-alkaline balance essential for health by boosting alkalinity. pH levels in the range of 7.35–7.45 provide many benefits. Because modern diets and lifestyles tend to produce acidic conditions (acidosis) in the body, it is important to recognize potassium’s role as “ultimate alkalinizer.”

Known benefits of ideal pH levels (slightly alkaline) include:

• Optimal function of enzymes
• Proper mineral retention, including electrolyte reserves
• Better tissue oxygenation
• Beneficial effects on microbiome

fruits vegetables potassium alkalinization

Consuming more potassium-rich fruits and vegetables can help maintain proper pH in the body.

The alkaline-forming minerals include potassium, magnesium, calcium, and sodium. They work together to keep you alkaline—all are important. Yet, in terms of what in your diet most drives alkalinity, potassium is the king. In fact, certain measures of pH indicate that alkalinity is a function of potassium intake. This means potassium intake most effectively creates alkaline conditions.

High dietary intake of potassium-rich, alkaline-forming fruits and vegetables (especially leafy green vegetables) and vegetable juices is the best way of supporting proper pH. This is a proven means for balancing the effects of acid-forming foods like meats, and most grains and starches (simple carbohydrates).

Known factors producing overly acidic conditions in the body include consuming meats, sugar, processed foods, and simple carbohydrates like wheat, corn, rice, and most pastas and breads.

IT’S REALLY ABOUT DIET?

TOO LITTLE POTASSIUM…TOO MUCH SODIUM

The human story behind potassium begins with dietary intake. Once upon a time, we “got plenty” of potassium in our diets. Now, not so much.

Indeed, humans have a long history of high potassium intake from foods. Our paleolithic ancestors ate a lot of vegetables, fruits, and nuts—all of which are high in potassium. This helped balance their intake of nutrients from animal foods, which are typically lower in potassium.

During the rise of agriculture (20,000–30,000 years ago) and settled communities, grains became a significant portion of our diet. Yet, grains contain relatively low levels of potassium.

In addition, salt was added to foods in larger quantities as a preservative and taste enhancer. A long, slow slide toward decreasing potassium levels— and simultaneously increasing sodium levels—was set in motion.

Sodium is an essential mineral for health—it is one of the alkalinizing minerals. But historically, humans obtained 5–10+ times as much potassium as sodium. We have now “successfully” reversed potassium preponderance by consuming 2–4 times as much sodium as potassium. This causes lots of problems, and is one of the major elements creating dysfunction in sodium-potassium pumps in cells (see above).

In our modern age, and especially since the later decades of the the 20th century, intake of fresh vegetables and fruits has fallen dramatically. And so has the dietary intake of potassium.

The 20th century witnessed an unprecedented and dramatic rise in consumption of processed, packaged, and “fast” foods — most of which are low in potassium and high in sodium.

Beyond the rise of processed foods, there are declines in nutrients (including potassium) in foods due to steadily poorer soil quality on farmland. And adverse impacts on nutrients in food crops relating to the rise of industrial agriculture—with its dependency on chemicals—and failure to replenish soils.

DIET REMAINS BEST TO INCREASE POTASSIUM INTAKE

Potassium remains high in vegetables and fruits, including dried fruits. And vegetable broths. The best solution to low intake of potassium in the diet is simply consuming higher levels of vegetables and fruits, especially those that are fresh and organic.

spinach leafy greens potassium alkalinity

Got spinach? It provides 800 mg potassium per cup!

Leafy greens (raw or cooked) are among the very best sources. Beet greens contain 1,300 mg of potassium per cup and spinach about 800 mg per cup.

Fresh carrot juice is my favorite providing nearly 700 mg per cup. Even comfort foods like baked potatoes (or sweet potatoes) provide high levels (1,000 mg) with skin. Avocado lovers rejoice, as there are 400–500 mg per avocado.

Beans and nuts are good sources, too. Fruits like bananas (400 mg), cantaloupe (350 mg), and even fruit juices like orange juice (650 mg) are significant sources. Among animal foods, fish, chicken, and pork are highest in potassium.

Nutritionists frequently suggest a 80–20 rule: simply consume 80% alkaline-forming foods to 20% acid-forming foods.

With this simple 80–20 formula, nearly everyone can achieve high—or at least adequate—potassium intake through their dietary choices.

The question is: Will people CHOOSE high-potassium foods? Do you?

SOLUTIONS FOR INCREASING POTASSIUM AND REDUCING SODIUM

You can point a person to high-potassium foods, but you can’t make them eat them. Despite exhortations from all sides for greater consumption of vegetables, fruits, nuts, and other high-potassium foods, “potassium sufficiency” isn’t the reality for most people. Potassium intake has been steady for decades.

Regarding sodium, it is just as easy (and important) for most people to decrease sodium in the diet as it is to increase potassium intake. Reduce use of salt. Choose low-sodium options when possible. Sodium is now on the radar as a mineral that promotes hypertension, so low-sodium options are increasingly available.

But like eating more fruits and vegetables, getting more exercise—and other things we know we “should” do—reducing sodium requires a conscious effort. The first part is awareness on the part of the individual. That leads to greater responsibility.

sodium salt shaker potassium

Too much sodium and insufficient potassium in the diet describes modern life.

I also believe manufacturers, restaurants, and the food industry in general should voluntarily limit the amount of sodium they put in foods. That would go a long way toward making it easier to reduce salt.

Coming back to potassium, an interesting fact is that based on US research, Finland in the 1990s replaced their salt shakers with potassium shakers. It’s true. And among other benefits, the incidence of strokes and heart attacks decreased by 60%.

Much can be done by individuals to improve their lives by increasing their potassium intake. Unless and until people eat enough high-potassium foods (and/or the US replaces its salt shakers with potassium shakers—which actually would help solve two problems), another viable option is potassium supplements.

POTASSIUM SUPPLEMENTS

For individuals who do not (or will not) consume sufficient potassium in their diets—this includes the vast majority of people—potassium supplementation can be beneficial.

Even for those who often consume adequate potassium, but sometimes fall short, supplementation is a useful option because it allows for increased potassium intake during times when they need more of it. And who doesn’t?

There are various potassium supplements, typically either capsules or alternate “salts” comprised partly or wholly of potassium bicarbonate. This form of potassium found naturally in fruits and vegetables (versus potassium chloride), and therefore is considered safe. Even when taken in amounts beyond normal recommended daily values, excesses will typically be excreted.

A few caveats. Most nutritional supplements only provide small amounts (100 mg) due to government rules created to avert “hyperalkemia,” defined as too much potassium in the blood. Hyperalkemia can be caused by acute or chronic kidney failure, so if you suffer from kidney failure, please leave potassium supplements alone.

Hyperalkemia can also be caused by medications, such as angiotensin-converting enzyme (ACE) inhibitors (taken for lowering high blood pressure, ironically), non-steroidal anti-inflammatory drugs (NSAIDS), and blood thinners like heparin. It may also relate to alcoholism, diabetes (type 1), or excessive use of potassium supplements.

The “normal” range of potassium in blood is 3.6–4.8 milliequivalents per liter (mEq/L).

On the reverse side: while most people get less than ideal amounts of potassium in their diets, deficiencies that would qualify as too little potassium (“hypoalkemia”) are not common. (Symptoms of hypoalkemia can include irregular heartbeat, muscle weakness, cramping, mood changes, nausea, and vomiting. Severe deficiencies may lead to muscle paralysis and abnormal heart rhythms.)

Given that most people do not obtain sufficient potassium, eating more fruits and vegetables and perhaps taking a high-quality potassium supplement will help the average person. That is, most people benefit from more potassium—not less—which they can get from diet and/or supplements.

pH ADJUST & POTASSIUM

HPDI recently launched pH Adjust, which is probably the world’s most sophisticated alkalinizing formula. pH Adjust is not a potassium supplement, per se. Yet, it provides easily assimilated potassium as part of a synergistic formula (including other important macrominerals) that is exceptionally well designed for increasing pH levels in the body.

pH Adjust potassium bicarbonate magnesium carbonate

pH ADJUST provides potassium and sodium bicarbonates and magnesium carbonate for alkalinity.

pH Adjust is already popular because many people are overly acidic due to dietary and lifestyle choices, including—but not limited to—not consuming enough vegetables and fruits and over-consuming meats, grains, and other acid-forming foods.

pH Adjust is an excellent formula for those interested in safely and rapidly increasing their pH to overcome acidosis, and creating alkaline conditions in the body.

One gram (1/4 teaspoon) of pH Adjust provides 141.7 mg of potassium from potassium bicarbonate and potassium glycinate. This means that one teaspoon — which is the amount I take daily — gives me 567 mg (.567 g) of potassium. That is not a huge amount of potassium, perhaps as much as you would obtain from mid-sized banana. However, if you consider that pH Adjust is a dietary supplement, which in conjunction with improved diet (i.e., consuming more potassium-rich foods) can make a difference in your potassium intake.

And for the many individuals whose potassium intake is less than 2.6 g — recall that 2.6 g is the AVERAGE intake — a 1/2 gram increase in potassium can make a big difference (a 20% boost!) in terms of improving total intake.

Then consider the “healthy” person whose potassium intake may hover around 4 g, which is above average, but less than the suggested 4.7 g intake level. One teaspoon of pH Adjust will move them into the range where they will meet— or get much closer to—the recommended daily intake.

pH ADJUST: MINERALS FOR ALKALINITY

Taking one teaspoon of pH Adjust daily not only helps boost potassium intake, but represents a HUGE move toward being alkaline, which is a major benefit for health, as I wrote in my last blog article.

Equally important in terms of alkalinizing the body, the bicarbonate form of potassium in pH Adjust is hugely alkaline-forming. That is, while potassium itself neutralizes acids in the body, potassium bicarbonate is substantially more alkalizing because of the tremendous alkaline-forming power of bicarbonate.

That is why HPDI created pH Adjust—to rapidly and effectively create alkaline conditions in the body.

Other significant facts: pH Adjust contains magnesium carbonate and sodium bicarbonate. Magnesium carbonate helps neutralizes stomach acids (hydrochloric acid) and then after it is absorbed (as magnesium ions) it continues to neutralize acids throughout the body. The sodium bicarbonate similarly splits: sodium neutralizes acids and bicarbonates alkalinize the body.

Moreover, it is known that without sufficient magnesium, cells cannot retain potassium. pH Adjust provides a significant amount (105 mg) of magnesium (from carbonate) per 1/4 teaspoon. Think about it—pH Adjust supplies more than 400 mg of easily assimilated magnesium in a single teaspoon! (This means you can reduce or drop your other magnesium supplements.)

pH Adjust provides a 3:1 ratio of potassium to sodium. This ratio is known to be ideal for optimal uptake of potassium.

supplement facts pH Adjust potassium magnesium sodium

pH Adjust provides 141.7 mg potassium and 105 mg magnesium per 1/4 teaspoon serving.

FINAL WORDS

Potassium powers sodium-potassium pumps in your cells and keeps you alkaline. It supports proper blood pressure and cardiovascular function. It balances the effects of sodium and works synergistically with other macrominerals keeping you healthy.

Potassium loves you. Yet, you hardly know potassium—or how deficient you are.

Love potassium like it loves you. Eat more potassium-rich fruits, vegetables, and fresh juices. Take a potassium-containing formula like pH Adjust. Not only will it supply you with easily assimilated potassium, but also powerfully boost your alkalinity.

Eat less salt. For God’s sake, eat less salt. Do all these things. Then it’s likely your poor sodium-potassium pumps will revive themselves. I promise, you will feel it!

 

RESOURCES

BLOG ARTICLES

Alkalinize Rapidly Using pH Adjust

pH Adjust Alkalinizing Formula – New Product!

BOOKS & SCIENTIFIC ARTICLES

The High Blood Pressure Solution by Richard D. Moore, MD, PhD

The K Factor: Reversing and Preventing High Blood Pressure without Drugs by Richard D. Moore, MD, PhD

The XXL Syndrome by Max Rombi, MD

Acid & Alkaline by Herman Aihara

Acid-alkaline balance: role in chronic disease and detoxification
(Altern Ther Health Med, 13(4):62-5)

Potassium Intake of the US Population (PDF)
(NHANES Food Surveys Research Group, USDA)

LIST OF HIGH-POTASSIUM FOODS

Potassium: Health Benefits, Recommended Intake

 

This article is dedicated to the memory of our friend Dr. Victor A. Galunic, who provided HPDI with information, resources, and technical assistance.