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RELIEF Rx™ REMEDY FOR MUSCLES, SKIN, AND JOINTS

Dr. Hank Liers, PhD Relief Rx™ pain sore musclesOne of our suppliers recently sent me a new product sample called Relief Rx™ to evaluate. The product is a topically-applied fast-acting “Aloe vera relief gel” for sore muscles, back, joints, and skin.

ReliefRx

After I applied the gel to painful or sore spots on my body, my pain and soreness was relieved in a short time — 15 minutes or less! I was quite impressed, needless to say. The gel has no odor and after it dries, it leaves no messy oils etc. on your skin—unlike many other topical skin formulas.

Because Relief Rx™ is a new product there are no prior sales data. However, our supplier also sent product samples to many other people who agreed to try it. The results experienced by the testers were nothing short of amazing — see some of their testimonials below.

 

 

RELIEF Rx™ INGREDIENTS

Aloe vera, a primary ingredient in Relief Rx™

Aloe vera is a primary ingredient in Relief Rx™

Aloe vera (organic)

The Egyptians called Aloe vera the “plant of immortality.” Aloe has been cultivated for centuries by indigenous people from Africa to Asia, and it is revered around the world by herbalists. As such, it may be the ultimate resource nature has provided for natural health.

The aloe extract in Relief Rx™ is carefully prepared with 100% organically grown plants, then compounded with a proprietary process to provide highly bioavailable constituents, such as acemannan and a full-spectrum of natural polysaccharides. Some of the known helpful effects of acemannan include:

  1. Helps cells to be more resistant to viruses and pathogenic bacteria.
  2. Improves overall cellular metabolism and functioning.
  3. Promotes healthy inflammation response.
  4. Provides critical lubrication of joints.
  5. Reduces pain.
  6. Improves vascular flow.
  7. Reduces scarring.
  8. Improves healthy macrophage activity.
  9. Increases the body’s own production of interferon, interleukins.
  10. Increases the number and activity of killer T-cell and increase monocyte activity.
  11. Fights fungal infections, such as: Athlete’s foot, Ringworm, Pruritus anivalvae, Balnea, Essential Pruritus, and Vaginal yeast infections/
  12. Helps athletic injuries such as: Muscle cramps, Sprains, Strains, Bruises, Swelling, Soreness, Tendonitis, and Bursitis.
  13. Helps with harmful organisms.
  14. Speeds wound healing..
  15. Anti-aging properties. Stimulate fibroblasts to release collagen and elastin to make new tissue.

You will feel the quality of the Aloe vera at work with every application.

Hemp

Hemp

Hemp Oil:
The hemp oil in Relief Rx™ is extracted from the flowers and leaves of the revered hemp plant. It is especially rich in bioactive molecules (without any psychotropic effects or side effects) and has gained worldwide recognition as a natural and potent therapeutic nutrient.

Select hemp oil molecules interact with our inherent endogenous cannabinoid (endocannabinoid) system to carry out beneficial and protective physiological reactions. First discovered in the late 1980s, the endocannabinoid system supports the body’s complex regulatory mechanisms including mood, sleep, appetite, hormones, pain, and immune response.

Relief Rx™ utilizes an advanced proprietary science that greatly enhances the efficacy of hemp oil to achieve results that are unequaled by conventional products.

White Willow Bark Extract (Salix alba)

White Willow Bark Extract (Salix alba)

White Willow Bark Extract (Salix alba):
A native of Europe and Asia, the name of this deciduous tree comes from the lightly colored undersides of its slender leaves. Willow may in fact be one of the oldest remedies, used in ancient Egypt and China as early as 500 BCE.

Healers applying skin and beauty treatments understood that willow bark was an important ingredient in the support of natural health. Careful processing ensures that the willow extract in Relief Rx™ contains the highest purity of ingredients. Benefits of using white willow bark extract include:

  • Anti-aging: A 2010 study reported that salicin can help reduce the appearance of skin aging. Researchers applied a serum product containing 0.5 percent salicin on the faces of women aged 35 to 70, every day for 12 weeks. Results showed improvements in the appearance of wrinkles, pore size, radiance, and overall appearance after only one week.

  • Helps cleanse oily skin: Willow bark extract naturally exfoliates skin and clears pores to give skin a clearer, healthier appearance.
  • Smooths the appearance of fine lines and wrinkles: The same exfoliating action that reduces clogged pores also helps smooth the look of fine line and wrinkles. Willow bark is a source of natural hydroxy acids that gently exfoliate. The result is smoother, softer skin.
  • Antioxidants: Like most plant extracts, willow bark contains flavonoids and tannins—powerful antioxidants that help protect skin from environmental stressors.
Relief Rx™ contains important trace minerals

Relief Rx™ contains important trace minerals

Ionic Trace Minerals Blend:
There is a great deal of evidence that the healthy function of the body is strongly influenced by electrical impulses. That is, our bodies use electrical impulse pathways, and electrolytes and ions are the conductors of these currents maintaining a smoothly running body. Ions provide the necessary charge of both positive and negative molecules that keep the electrical component of the human battery “charged” and working in top form.

The human skin is the largest organ of the body and is highly involved in the detoxification and maintenance processes of health. Skin not only excretes and eliminates toxins; it also has a tremendous capacity to absorb health supportive substances.

Clinical researchers have continued to document the clinical findings that have been observed for decades when it comes to the healing properties of topical minerals. Many of the studies on therapeutic baths have used minerals from the Dead Sea as well as the Great Salt Lake. Of particular interest are the powerful effects of these salts that exhibit favorable effects in inflammatory disease.

In one study, 103 arthritic patients received various bath treatments with ionic trace minerals. The study showed impressive results and those with the greatest physical limitation had the most pronounced improvement. A large percentage of the patients reported having less pain, improved mobility and were able to decrease analgesic use. In a different double-blind study, the use of warm mineral baths demonstrated a lasting effect for patients suffering from degenerative arthritis.

In a clinical trial conducted by a leading research university in Germany, patients with atopic (eczema) skin disorders immersed their arms in a mineral rich bath. The participants immersed one arm in tap water the other in the therapeutic mineral rich bath. The findings showed that skin hydration was improved and skin roughness and inflammation was reduced when immersed in the mineral rich water.

RELIEF Rx™ USAGE

Direction for use:
Apply a generous amount of gel to stressed muscles and joints as needed for soothing harmonious comfort, creating a moist surface. Allow the moisture to absorb naturally into the skin and air dry on its own. Keep tightly sealed and away from children. For external use only.

Ingredients:
Purified water, Glucomannan, Organic Aloe vera, Ionic Trace Elements Blend, Hemp Oil, White Willow Bark Extract, Citric Acid, Potassium Sorbate, Sodium Benzoate.

RELIEF Rx™ TESTIMONIALS

Relief Rx™ is a new product with no prior sales data. The product was sent out to a number of people who agreed to try it. The results obtained were amazing as shown in the testimonials given below. Personally, we can confirm that the product works extremely well for a variety of muscle and joint issues – usually providing sustained relief within a short time after applying the gel to the skin.

1. Ole G., Topanga, California: “I am an 88-year old retired mechanical engineer with multiple knee, hip and upper back chronic discomfort, that is UNTIL I FOUND Relief Rx. All of it was gone in a matter of minutes. I now use this gel only when I over exert myself during yard work and gardening. I love this product…!!”

2. Paul G.: “In all of my 35+ years in the fitness facility business I never saw a relief product that works as good as Relief Rx™. This stuff is on the verge of being miraculous……truly amazing”

3. Charlie L: “I had a slight tear in the meniscus of my left knee that bothered me if I stood or sat for long. I applied Relief Rx™, and was amazed. In less than 20 seconds – literally, my knee was back to normal. I wasn’t expecting it to work that well or that quickly.”

4. Katie L (49): “I have used the Relief Rx™ many times when my muscles have been sore or my joints achy and each time, within minutes, the pain has diminished if not gone away completely. I don’t really understand why this happens, I just know it does. I appreciate the simplicity of the liquid – it is not thick, or smelly or difficult to use. And it seems to absorb quickly. It does not leave behind residue, any fragrance or greasy feeling. So I’m not so sure what is in it. I just know that it works wonders. Thank you for bringing this product to market. I’ve thrown out all of my other products and just use this.”

5. J.G.: “I have had severe pain in my right hand for over two years from using the mouse, pain in my arm, and recently I had surgery and developed a very uncomfortable pain on my right side from lying in bed. Every time I use Relief Rx™ I am amazed at how quickly the pain subsides and disappears. Thank you for this wonderful product!”

6. Dr. Chuck A.: “I applied Relief Rx™ on a patient that had nagging back issues. She told me she had “immediate and significant relief”. When can I get more?”

7. Mike G.: “I have played handball for 50 years. Over that time I have suffered right shoulder problem from injury, strain from over use, and tension from rotator cuff surgery. Over the past 15 years I have had to change shots due to shoulder problems and limitations. I applied Relief Rx™ and within 30 minutes I was 100%! I can hit all of the shots on the handball court like I could 15 years ago.”

8. U.: “This is the most amazing relief product I have ever experienced. I have disturbing problem in my back and it prevents me from getting a full nights sleep. Last night is the first night of continuous sleep I’ve had in more than a year.”

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BENEFITS OF GINKGO BILOBA EXTRACT

Dr. Hank Liers PhD gingko biloba extractHealth Products Distributors, Inc. (HPDI) has been carrying high-quality standardized Ginkgo Biloba extract (24/6) for more than 20 years. Ginkgo biloba extract is one of the best-selling herbal supplements in the United States and Europe because of its health benefits. Yet, because of severe price increases in ginkgo extract during the last few years, HPDI’s inventory was depleted. However, the price has now been greatly reduced for high-quality material—and we have inventory back in stock.

Ginkgo Biloba Tree

Ginkgo Biloba Tree

Ginkgo biloba has a long history of use (over thousands of years) in treating memory issues and blood disorders. Today, It is best known as a way to keep memory sharp. Laboratory studies have shown that Ginkgo biloba improves blood circulation by opening up blood vessels and making blood less sticky. Research studies also show that it is a powerful antioxidant.

Based upon these properties, Ginkgo biloba may improve blood vessel and eye health. Research has clearly shown that Ginkgo Biloba helps with dementia and poor circulation in the body. It also protects memory in older adults.

TECHNICAL DATA

Ginkgo leaves contain flavonoids and terpenoids, which are both antioxidants. In your body, harmful free radical substances build up as you age and may contribute to a range of health issues. The antioxidants found in Ginkgo biloba help to neutralize free radicals, and prevent them from damaging DNA and other cellular structures.

Leaves of Ginkgo Biloba Tree

Leaves of Ginkgo Biloba Tree

Chemical constituents: Ginkgo biloba leaf contains a complex mixture of flavonoids including: quercetin, kaempferol, isorhamnetin and other glycosides. It also contains unique diterpenes including ginkgolides A, B, C and J, sesquiterpene bilobalide, and other natural compounds that contribute in a synergistic manner to the beneficial actions of Ginkgo biloba.

Our GINKGO BILOBA extract contains only the highest-quality 50:1 extract of ginkgo biloba standardized to 24% minimum ginkgoflavonglycosides and 6% minimum combined ginkgolides A, B, C, and bilobalide. Each capsule contains 120 mg of the extract and their are 60 capsules in a bottle. Other ingredients include: microcrystalline cellulose, HPMC (vegetarian capsule), and silica. The ginkgolic acid content of the current production run is is 1.36ppm.

Here is the Certificate of Analysis of our current run of Ginkgo Biloba.

Ginkgo Biloba extract

Ginkgo Biloba 120 mg

 

SPECIFIC BENEFITS: GINKGO BILOBA EXTRACT

Reduces Conditions of Dementia: Scientific literature suggests that Ginkgo biloba extract benefits people experiencing cognitive decline, including those with dementia of Alzheimer’s disease (AD). Certain studies have found Ginkgo biloba can help improve cognitive performance and memory in both older and younger adults but might be especially useful for age-related mental decline.

Improves Concentration: Research shows that Ginkgo biloba extract can help combat poor concentration, reverse cognitive decline and and heal fatigue. It’s even useful for helping to treat cerebral insufficiency — a condition characterized by chronically low concentration, confusion, decreased physical performance, fatigue, headaches and mood changes.

Helps With ADHD: Some studies using therapies that include Ginkgo biloba have found relief and improved concentration for people with ADHD symptoms. And because it can improve concentration, memory and task performance, it may also reduce symptoms in people with dyslexia. There is also some evidence that ginkgo biloba can help reduce symptoms of autism, making it a potential autism natural treatment.

Helps with Headaches and Migraines: Ginkgo biloba can be an effective way to naturally reduce frequent headaches and the rate and severity of migraines because it reduces pain, increases blood vessel dilation and combats stress that can trigger problems. Headaches may be triggered by stress, fatigue, poor posture, drugs, low blood sugar, hormones, constipation, allergies, eyestrain, and nutritional deficiencies. The amazing benefits that ginkgo has on stress and fatigue is associated with its ability to lessen headache tension.

Helps With Anxiety and Depression: For those with nervousness, depression or mood swings, Ginkgo biloba extract can be helpful. Research suggests Ginkgo biloba benefits the body’s ability to handle stressors and counteracts the effects of high levels of stress hormones, like cortisol and adrenaline.

Ginkgo biloba is considered to be an adaptogenic herb that naturally raises the body’s ability to cope with stress. It can be especially helpful for people with generalized anxiety disorder (GAD) and possibly seasonal depression, panic attacks and social phobias.

Reduces Symptoms of Asthma: Studies have found Ginkgo biloba extract can reduce asthma-related symptoms. Because it lowers inflammation, improves antioxidant activity and positively effects nerve functioning, people have reported less trouble breathing when taking Ginkgo biloba.

Alleviates Symptoms of PMS: Early research has shown positive effects of taking Ginkgo biloba on reducing PMS symptoms, including mood swings, headaches, anxiety, fatigue and muscle pain. It also may have beneficial effects on mood and cognition in postmenopausal women and can help improve similar symptoms.

Helps Maintain Vision and Eye Health: Ginkgo biloba appears to be beneficial for eye health since it improves blood flow to the eyes and prevents free-radical damage that can affect the cornea, macula and retina. It can be especially beneficial for older adults in preserving vision and lowering UV damage or oxidative stress to eye tissue.

Improves Libido: Ginkgo biloba has positive effects on hormonal balance — particularly serotonin levels, blood pressure and circulation. This implies that it may help those dealing with erectile dysfunction and low libido. Ginkgo biloba has the potential to dilate blood vessels and improve blood flow to the genitals, which is important for reproductive health.

Helps Heal Hemorrhoids: Some studies have found that Ginkgo biloba helps those experiencing painful hemorrhoids, that cause swelling, pain and bleeding related to an increase in pressure on the veins of the anus and rectum. Ginkgo biloba may lower pain, improve pain tolerance and reduce inflammation, which may stop bleeding associated with hemorrhoids.

GINKGO BILOBA RESEARCH SUMMARY

Provided below are abstracts from some recent meta-analysis studies that document the effectiveness of Ginkgo biloba on mental health.

(ABSTRACT 1)
Tan MS, Yu JT, Tan CC, Wang HF, Meng XF, Wang C, Jiang T, Zhu XC, Tan L

Efficacy and adverse effects of ginkgo biloba for cognitive impairment and dementia: a systematic review and meta-analysis.

In: J Alzheimers Dis. 2015;43(2):589-603. doi: 10.3233/JAD-14083

Research into Ginkgo biloba has been ongoing for many years, while the benefit and adverse effects of Ginkgo biloba extract EGb761 for cognitive impairment and dementia has been discussed controversially.
OBJECTIVE: To discuss new evidence on the clinical and adverse effects of standardized Ginkgo biloba extract EGb761 for cognitive impairment and dementia.
METHODS: MEDLINE, EMBASE, Cochrane, and other relevant databases were searched in March 2014 for eligible randomized controlled trials of Ginkgo biloba EGb761 therapy in patients with cognitive impairment and dementia.
RESULTS: Nine trials met our inclusion criteria. Trials were of 22-26 weeks duration and included 2,561 patients in total. In the meta-analysis, the weighted mean differences in change scores for cognition were in favor of EGb761 compared to placebo (-2.86, 95%CI -3.18; -2.54); the standardized mean differences in change scores for activities in daily living (ADLs) were also in favor of EGb761 compared to placebo (-0.36, 95%CI -0.44; -0.28); Peto OR showed a statistically significant difference from placebo for Clinicians’ Global Impression of Change (CGIC) scale (1.88, 95%CI 1.54; 2.29). All these benefits are mainly associated with EGb761 at a dose of 240 mg/day. For subgroup analysis in patients with neuropsychiatric symptoms, 240 mg/day EGb761 improved cognitive function, ADLs, CGIC, and also neuropsychiatric symptoms with statistical superiority than for the whole group. For the Alzheimer’s disease subgroup, the main outcomes were almost the same as the whole group of patients with no statistical superiority. Finally, safety data revealed no important safety concerns with EGb761.
CONCLUSIONS: EGb761 at 240 mg/day is able to stabilize or slow decline in cognition, function, behavior, and global change at 22-26 weeks in cognitive impairment and dementia, especially for patients with neuropsychiatric symptoms.

(ABSTRACT 2)
Amieva H1, Meillon C, Helmer C, Barberger-Gateau P, Dartigues JF.

Ginkgo biloba extract and long-term cognitive decline: a 20-year follow-up population-based study.

In: PLoS One. 2013;8(1):e52755. doi: 10.1371/journal.pone.0052755. Epub 2013 Jan 11

BACKGROUND: Numerous studies have looked at the potential benefits of various nootropic drugs such as Ginkgo biloba extract (EGb761®; Tanakan®) and piracetam (Nootropyl®) on age-related cognitive decline often leading to inconclusive results due to small sample sizes or insufficient follow-up duration. The present study assesses the association between intake of EGb761® and cognitive function of elderly adults over a 20-year period.
METHODS AND FINDINGS: The data were gathered from the prospective community-based cohort study ‘Paquid’. Within the study sample of 3612 non-demented participants aged 65 and over at baseline, three groups were compared: 589 subjects reporting use of EGb761® at at least one of the ten assessment visits, 149 subjects reporting use of piracetam at one of the assessment visits and 2874 subjects not reporting use of either EGb761® or piracetam. Decline on MMSE, verbal fluency and visual memory over the 20-year follow-up was analysed with a multivariate mixed linear effects model. A significant difference in MMSE decline over the 20-year follow-up was observed in the EGb761® and piracetam treatment groups compared to the ‘neither treatment’ group. These effects were in opposite directions: the EGb761® group declined less rapidly than the ‘neither treatment’ group, whereas the piracetam group declined more rapidly (β = -0.6). Regarding verbal fluency and visual memory, no difference was observed between the EGb761® group and the ‘neither treatment’ group (respectively, β = 0.21 and β = -0.03), whereas the piracetam group declined more rapidly (respectively, β = -1.40 and β = -0.44). When comparing the EGb761® and piracetam groups directly, a different decline was observed for the three tests (respectively β = -1.07, β = -1.61 and β = -0.41).
CONCLUSION: Cognitive decline in a non-demented elderly population was lower in subjects who reported using EGb761® than in those who did not. This effect may be a specific medication effect of EGb761®, since it was not observed for another nootropic medication, piracetam.

(ABSTRACT 3)
Zhang HF, Huang LB, Zhong YB, Zhou QH, Wang HL, Zheng GQ, Lin Y

[An Overview of Systematic Reviews of Ginkgo biloba Extracts for Mild Cognitive Impairment and Dementia.

In: Front Aging Neurosci. 2016 Dec 6;8:276. doi: 10.3389/fnagi.2016.00276. eCollection 2016

Ginkgo biloba extracts (GBEs) have been recommended to improve cognitive function and to prevent cognitive decline, but earlier evidence was inconclusive. Here, we evaluated all systematic reviews of GBEs for prevention of cognitive decline, and intervention of mild cognitive impairment (MCI) and dementia. Six databases from their inception to September 2015 were searched. Ten systematic reviews were identified, including reviews about Alzheimer’s disease (n = 3), about vascular dementia (n = 1), about both Alzheimer’s disease and vascular dementia (n = 2), about Alzheimer’s disease, vascular dementia and mixed dementia (n = 3), and a review about MCI (n = 1). Based on the overview quality assessment questionnaire, eight studies were scored with at least 5 points, while the other two scored 4 points and 3 points, respectively. Medication with GBEs showed improvement in cognition, neuropsychiatric symptoms, and daily activities, and the effect was dose-dependent. Efficacy was convincingly demonstrated only when high daily dose (240 mg) was applied. Compared with placebo, overall adverse events and serious adverse events were at the same level as placebo, with less adverse events in favor of GBE in the subgroup of Alzheimer’s disease patients, and fewer incidences in vertigo, tinnitus, angina pectoris, and headache. In conclusion, there is clear evidence to support the efficacy of GBEs for MCI and dementia, whereas the question on efficacy to prevent cognitive decline is still open. In addition, GBEs seem to be generally safe.

(ABSTRACT 4)
Hashiguchi M, Ohta Y, Shimizu M, Maruyama J, Mochizuki M.

[Meta-analysis of the efficacy and safety of Ginkgo biloba extract for the treatment of dementia.In: J Fr Ophtalmol (1988) 11(10):671-4 (Published in French)]

In: J Pharm Health Care Sci. 2015 Apr 10;1:14. doi: 10.1186/s40780-015-0014-7. eCollection 2015.

The benefit of Ginkgo biloba for the treatment of dementia remains controversial. The aim of this study was to evaluate the efficacy and safety of Ginkgo biloba in patients with dementia in whom administration effects were reported using meta-analysis.
METHODS: We searched MEDLINE, Embase, the Cochrane databases, and Ichushi for controlled trials of Ginkgo biloba for the treatment dementia. Clinical characteristics and outcomes were extracted. Meta-analysis results were expressed as standard mean differences (SMDs) in scores of the Syndrome Kurztest (SKT), Alzheimer’s Disease Assessment Scale Cognitive Subscale (ADAS-Cog) for cognition efficacy, or odds ratios (ORs) for dropouts and adverse drug reactions.
RESULTS: Thirteen studies using the extract EGb761 met our inclusion criteria, which were duration of 12 to 52 weeks and daily dose of more than 120 mg, and included a total of 2381 patients. Meta-analysis was performed by using 9 of 13 studies, 7 of which used the SKT and 2 ADAS-Cog (dose 120 mg, 26 weeks) scores as efficacy parameters. In meta-analysis of all patients, SMDs (95% confidence interval [CI]) in the change in SKT scores (7 studies) were in favor of Ginkgo biloba over placebo (SMD = -0.90 [-1.46, -0.34]), but 2 studies that used ADAS-Cog did not show a statistically significant difference from placebo for ADAS-Cog (-0.06 [-0.41, 0.30]). For Alzheimer’s disease (AD) and vascular dementia (VaD) subgroups, SMDs [95% CI] in SKT in the combined AD and VaD subgroup (-1.07 [-1.66, -0.47]) and AD subgroup (-1.36 [-2.27, -0.46]) were in favor of Ginkgo biloba over placebo. In terms of daily dose of Ginkgo biloba in the combined AD and VaD subgroup, SMD in SKT score in 240-mg daily dose groups was significantly greater than with placebo (-0.71 [-1.28, -0.14]). Dropout rates for any reason did not differ between two groups, but dropout rates due to side effects were significantly lower in Ginkgo biloba groups compared with placebo groups (OR = 1.72 [1.06, 2.80]).
CONCLUSIONS: Taking a 240-mg daily dose of Ginkgo biloba extract is effective and safe in the treatment of dementia.

For a more extensive list of Ginkgo Biloba abstracts go here.

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THE SCIENCE BEHIND MEGAHYDRATE

Dr Hank Liers PhD science behind MegahydrateI recently became aware of the health benefits of molecular hydrogen/hydrogen. We subsequently have written numerous blog articles on the subject (see resources section below), and elected to carry and endorse several products, including Active H2 and Megahydrate™. As a scientist, I am particularly impressed with the science behind Megahydrate, as well as the in-depth research studies carried out showing how it was developed and its health benefits.

For economic reasons, it is rare for a particular nutritional supplement to have in-depth scientific studies and clinical trials supporting its use. In this article, I will present some of the most relevant scientific information regarding Megahydrate.

 science behind Megahydrate

In a previous article “Water, Hydration, and Crystal Energy®” I discuss in-depth the science behind Dr. Patrick Flanagan’s use of nanometer-sized silica colloids to enable greater hydration of the body, enhanced absorption of nutritional ingredients into cells, and improved cellular detoxification.

In this article I will discuss the science and benefits of embedding hydrogen anions (hydride or H-) into these same nanometer-sized silica colloids that not only have all of the hydration benefits of Crystal Energy® but also exhibit potent antioxidant characteristics. The resulting substance is named by Dr. Flanagan “silica hydride” and his product that incorporates it is known as Megahydrate™ (originally Microhydrin™). The science behind the development of Megahydrate is provided below.

DEVELOPMENT OF AND SCIENCE BEHIND MEGAHYDRATE

The details of the materials development are provided in an article by Cory J. Stephenson and G. Patrick Flanagan titled “Synthesis of Novel Anionic Hydride Organosiloxane Presenting Biochemical Properties” published in the International Journal of Hydrogen Energy 28 (2003) 1243–1250.

Abstract
Synthesis of an anionic hydride from monomeric silsesquioxanes is described. The novel compound, dubbed “silica hydride” is the result of several newly synthesized compounds from an interstitially embedded hydride family. It is a hydride-based compound with H− ions interstitially embedded in a matrix of caged silica. This compound exhibits profoundly different characteristics than other known compounds in the hydride family. Unlike saline hydrides, the silica hydride demonstrates no overt or violent reaction with water or air. However, it is capable of generating aqueous reductive potential readings (ORP) of −750 mV for extended time periods. In vitro biological testing demonstrated no cytotoxicity induced by the compound while demonstrating efficacy as an antioxidant. In vivo studies of the compound have shown that it has a significant ability to reduce lactic acid build up in muscles by one-half after exercise. The synthesis of the silica hydride resulted in an approximately 16.8% w/w hydride content, as determined by density changes, proton NMR spectroscopy and ion beam analyses. Scanning and tunneling electron microscopy, Rutherford backscattering spectroscopy (RBS), forward recoil (FReS) ion beam analyses, in addition to Fourier transform infrared spectroscopy, reduction potential and 29Si CP-MAS solid state NMR were additionally used to characterize the compound.

Below relevant details from the article are provided to give insight into the science of the Megahydrate invention.

Introduction: The idea behind synthesis of the novel compound described in this article is based on the use of a monomer nanocomposite as a carrier in a bioencapsulated compound. The synthesis uses a silica and hydroxyl group terminated silsesquioxane monomer, trademarked Silica Microclusters®, that is interstitially imbedded with hydride anions as conceptually depicted in Fig. 1. The results from the characterization of this compound provide evidence to this claim, including DRIFTS FTIR and NMR data.

Figure 1 science behind Megahydrate

Figure 1. Conceptual diagram of Flanagan Microcluster structure. The tetrahedral coordination forms a three-dimensional framework by a series of Si–O–Si bonds, creating a silica cage.

With the immense potential for bioencapsulates and nanocomposite technologies, it would be very beneficial to create a hydride out of a compound that would involve the combinational reducing effects of a saline hydride compound and the beneficial attributes of the host compound, all without the reactivity of the saline hydrides. Synthesizing a biologically friendly hydride would have immense potential as an antioxidant and radical scavenger as discussed later in this paper.

It was discovered in the present work that if a hydride ionic plasma was placed under pressure, virtually any compound it came in contact with could then absorb its emitted ions. Since the 1920s, creating a hydride gas has been standard practice. One effective way is to add a current to a tungsten (W) lament in a hydrogen gas atmosphere. The lament separates hydrogen gas into a monovalent hydrogen gas while the photoelectric effect on the W lament donates electrons to the H gases forming a H− plasma. Langmuir, in 1927, while using the W lament hydride ion synthesis technique, discovered that moist air prevents hydride ions from recombining back into hydrogen gas.

Figure 2 science behind Megahydrate

Figure 2. The Concept of Silica Hydride. Conceptually the hydride embedded organosiliceous silsesquioxane, or silica hydride, is a monomeric silica-based cage with interstitially placed hydride anions. As a bioencapsulated compound, the silica acts as a colloidal carrier for the hydrogen anions in solution.

Details of Invention: The idea for this synthesis experiment was to then create a hydride plasma under a water vapor atmosphere and expose the plasma to an organosilicate compound, circumventing the problem of the hydrogen not having the catalysis or the electron availability to combine with the host substrate. Interestingly, Langmuir noted that the monoatomic ions produced by this process would become embedded in the glass walls of the tubing of his apparatus and that same tubing could later be induced to release the ions. The glass tubing used by Langmuir was a borosilicate glass, an amorphous siliceous compound. In the present study, an apparatus similar to what Langmuir used was constructed to create a plasma of H− ions. The H− atmosphere was applied to the pure Microcluster Silica powder under pressure and in the presence of a water vapor, creating a novel silsesquioxane bioencapsulated-hydride compound, dubbed: silica hydride.

Materials and methods: A 1.0 L sealed glass vessel was fabricated containing the items as depicted in Fig. 3. Two 5 cm × 0:6 cm diameter W rods were positioned transversely 2 mm apart in the top of the reaction vessel with two insulated leads connecting the W rods to a 20 A constant-current transformer (Lambda-EMI 102A-1KV, Neptune, NJ). Ten grams of MicroclusterJ silica was placed on the stage inside the vessel with 100 ml of distilled and deionized water added to the basin. A steady stream of hydrogen gas was bubbled through an aquarium stone in water and introduced to the reaction vessel, purging all of the air from the vessel and increasing pressure to 172 kPa at which time the vessel was sealed. A 500 V potential was applied to the W rods. At voltages ranging from 350 to 750 V, a constant arc could be maintained between the electrodes without melting. The potential was applied for 30 seconds at which time the current was shut off  and additional hydrogen was pumped into the vessel creating a captive plasma. The sample was allowed to sit in the plasma for 30 minutes at which time the silica sample was removed and weighed with an analytical balance.

Figure 3 science behind Megahydrate

Figure 3. Synthesis Apparatus. The representation of the apparatus used to synthesize the compound. A hydrogen gas generator (A) provides H2 gas that is sparged through a fllter stone in deionized, distilled water (B), where the hydrogen gas and water vapor are transported into a reaction vessel (C) with the substrate. Two tungsten electrodes (D) create a captive plasma H− gas via a constant current high-voltage power supply (E). Vessel evacuation, purge and sealing were performed using a mechanical valve (F). The resultant actions interstitially embed the hydride anions created by the plasma into the substrate.

Results: Determination of the mass of the anionic hydride organosiloxane sample showed an increase from 10.0 to 11.70 g upon exposure to the hydride plasma under pressure. The sample was allowed to sit at room temperature with desiccant in a glass vial for 3 weeks at open atmosphere at which time the proceeding analyses were performed.

An ion beam analysis was performed with the silica powder being pressed into a pellet (1.66 g/cm3) compared to a control standard. Rutherford backscattering spectroscopy (RBS) was analyzed with 2 MeV He beam, while 3 MeV He beam was used in a forward-recoil spectrometry (FReS) measurement. RBS suggests that the powder contains elements O and Si. Including H- content by FReS, the powder relative percentage makeup becomes H (78.1%), O (15.6%) and Si (6.2%). Trace amounts of boron (B) and W (<25 ppm) were also observed. Original values from samples of non-reacted Microcluster silica comparatively illustrate an elemental makeup of H (22.4%), O (55.6%) and Si (21.9%). A 1H-NMR characterization was performed and showed a 16.8% hydride content.

Scanning electron microscopy analysis with a 40 KeV-JEOL 840II microscope illustrated small, ∼ 2 microns, spheres consisting of numerous smaller spheres. A 300 KeV-CM30 transmission electron microscope allowed the resolution to image very small, spherical compounds that were measured to be about 50 Angstroms. An energy dispersive X-ray spectrometer qualified an elemental analysis of the compound to contain Si and O.

The ORP and pH were recorded for 250 ml distilled and deionized water in a Pyrex beaker. 10.0 g/ml of the siliceous hydride was added to the beaker and allowed to stir for 15 min at which time addition ORP and pH readings were taken. The initial ORP and pH of the water averaged 341.33±2.5 mV and pH 7.12±0.06, respectively. The readings after 15 min were −436.21 ± 2.1 mV for the ORP and 9.13 ± 0.09 for the pH measurements.

The hydrogen pressure unbiased reducing potential, rH, was calculated. The use of rH gives a hydrogen proton-unbiased look at the absolute reducing potential of a compound, eliminating the effects of pH in the ORP measurement. The measured rH for the compound was 11.02 ± 0.04 indicating a highly reduced environment.

Discussion: The synthesis process appears to cluster the organosilicate subunits into hydrogen-bonded aggregates that further group into approximately 2 micron clusters as shown in Fig. 4A. Dissolution in water decreases the cluster size from 2 microns to the smaller subunits of about 500 nm, then into individual cages of about 50 A (Fig. 4B).

 Figure 4 science behind Megahydrate

 

This new organosilicate silsesquioxane compound, commonly named silica hydride, has been the subject of numerous tests involving reduction potential (ORP) and pH as well as being analyzed as an effective antioxidant. Adding a few mg to water will drop an ORP reading by −750 mV. A recent publication of a clinical study has illustrated the capability of this compound to significantly reduce lactic acid after exercise by 50%. Viability and cytotoxicity probes show that the silica hydride does not cause any decrease in intracellular esterase activity or otherwise induce a toxic cytoplasmic environment. There are a plethora of uses of a hydride-based compound such as silica hydride since it does not impose a direct negative effect to cellular viability and cytoplasmic health. Particular uses include nutritional supplementation as an antioxidant. The incredible reduction potential of silica hydride adds to the possible uses of this type of compound.

The compound does not react violently or visibly with H2O. However, it will reduce the ORP reading to −750 mV for a period of at least several weeks. Most antioxidant compounds are relatively large chemical species. Examples of this are vitamins A, K, C, ubiquinone and n-acetyl-l-cysteine. It is hypothesized that steric hindrances may affect the efficacy of antioxidants. The small size and reducing capacity of silica hydride, the silsesquioxane hydride compound, may lead to future development as an antioxidant.

Conclusion: The novel siliceous compound acts as a colloidal carrier for the very small hydride anions that are released in an aqueous solution. This nanosized colloidal bioencapsulated compound could be an incredibly effective radical scavenger and aid in the reduction of oxidative stress due to its minimal size and high reduction potential.

This novel compound presented in this paper has demonstrated promising in vitro and in vivo biochemical significance with uses including reducing agents, antioxidants and nutritional supplementation. The synthesis is simple and effcient with consistent results of about 17% w/w hydride content with respect to the starting compound. Biologically friendly compounds that incorporate health-beneficial minerals, such as silica, with the scavenging and reducing capabilities of a hydride provide for numerous possibilities of uses.

THE PATENT AND SCIENCE BEHIND MEGAHYDRATE

After inventing Megahydrate (formerly Microhydrin), Dr. Flanagan (and his associates) conducted studies on its efficacy for a range of benefits for human health. The material was then patented in 2003. Key elements of the patent are provided below and a link to the entire content is provided if you wish to read further details.

Methods of using silica hydride mineral
US 20030190374 A1

ABSTRACT

The exact health benefits of silica hydride minerals, traditionally found in glacial streams, have long been the subject of speculation. Geochemical analysis indicates that such colloidal silica hydrides in water possess a silica-water interface that provides a hydrated surface and adsorbs other elements or compounds such as potassium, iron, magnesium, lithium, calcium, and hydrogen. Dietary supplements with similar properties have been formulated. When the silica-water interface of such compounds is saturated with reduced hydrogen, the compounds take on an overall negative charge and act as a reducing agent or antioxidant when in solution. When consumed, hydride ions introduced into the body by the silica hydride supplement donate electrons to body fluids. With proper dosages, the benefits of consuming silica hydride include reduction of lactic acid build-up, increasing cellular hydration, reduction of free radical damage, enhancement of mitochondrial bioenergetic capacity, increasing antioxidant activity, and enhancing the properties of drinking water.

DESCRIPTION

TECHNICAL FIELD OF THE INVENTION
This invention relates to methods of using silica hydride minerals. More particularly, this invention relates to methods of using silica hydride minerals that have beneficial effects on lactic acid buildup during exercise, cellular hydration, free radical damage, mitochondrial bioenergetic capacity, antioxidant activity, and the suitability of water for conversion into optimal cellular body fluids.

BACKGROUND OF THE INVENTION
Amorphous silicate minerals, many of which are in the nanoparticle size range, were once common in natural water sources and abundant in glacial stream waters. Not only do the silica mineral particles bond water and other elements for transport; they also can be adsorbed with reduced hydrogen, which releases electrons, providing antioxidant or reducing potential to surrounding fluids.

In one region of West Pakistan the people are known to enjoy excellent health and amazing longevity. A team of cardiologists found the heart health of the people to be exceptionally good and evidence of the people’s delayed aging. The cardiologists attributed the good health and longevity in significant part to the abundance of colloidal silicate minerals in the glacial streams the people used for irrigation of food crops and drinking water.

Geochemical analysis indicates that colloidal silicate minerals display a variety of properties, including the formation of structured water around the silica-water interface, which provides a hydrated surface that adsorbs elements or compounds such as potassium, iron, magnesium, lithium, calcium, and hydrogen. FIG. 5 illustrates an example of the silica-water interface and the concentric structured water arrangement about the interface with the adsorption of elements within the layers.

Figure 5 science behind Megahydrate

Figure 5. An enlarged view of a hypothetical silica hydride particle showing the silica-water interface and other adsorbed elements.

 

From silicate analogs, it is possible to formulate dietary supplements that are similar to the colloidal silicate minerals found in glacial waters and retain the geo-physical properties inherent to these minerals. An example of such synthesized silicate analogs is a silica hydride formula sold under the trademark Microhydrin®. Substances possessing the characteristics and functions described in this application, such as Microhydrin®, have assumed many names.

For example, in addition to being called silica hydrides, such substances are known as amorphous silicate minerals, silicate particles, silicates, colloidal silicate minerals, silicate analogs, synthesized silicate analogs, functional silicate nanocolloids, dielectric interstitial hydrides, dietary silicate supplements, or dietary silicate antioxidants. Considering the many labels afforded this class of substances, the characteristics and functions of supplements must necessarily determine whether a particular supplement falls within the class.

Referring again to FIG. 5, the particle’s silica-water interface can be saturated with reduced hydrogen, or hydride (H-) ions, and takes on an overall negative charge. In such cases, the particle then acts as a reducing agent or antioxidant when in solution (standard reduction-oxidation potential, −550 mV). It is capable of providing literally trillions of hydride ions able to donate electrons into body fluids.

Electrons, which Albert Szent-Gyorgyi called the “fuel of life,” are abundantly available in inorganically grown raw vegetables, fruits, and grains, but are deficient in our modem diet of over-cooked, acidic, or highly oxidized foods, beverages, and drinking water. In silica hydride minerals, the structured water around the silica-water interface stabilizes electron transfer. Such specific silicate interactions could play a substantial role in many biological processes by enhancing salvation properties and ion and water transport and by providing free radical antioxidant protection.

Such electron deficiencies resulting from inadequate diet have a derogatory impact on specific biological processes such as lactic acid build-up, cellular hydration, damage from free radicals, mitochondrial bioenergetic capacity, antioxidant activity, and suitability of drinking water for conversion into optional cellular body fluids. Therefore, a need exists for a method of counter balancing these electron deficiencies and, as a result, enhancing each of these biological phenomena.

SUMMARY OF THE INVENTION
The present invention identifies certain beneficial health effects of silica hydride minerals and the effective doses necessary to achieve desired results. With proper dosages, the benefits of using silica hydride minerals as a dietary supplement include: reduction of lactic acid buildup during and after exercise, increasing cellular hydration, reduction of free radical damage, enhancement of mitochondrial bioenergetic capacity, increasing antioxidant activity, and enhancing the suitability of water for conversion into optimal cellular body fluids.

PATENT CLAIMS

1. A method of reducing lactic acid buildup during and after exercise comprising ingesting an effective dose of silica hydride mineral.
2. A method of increasing cellular hydration comprising ingesting an effective dose of silica hydride mineral.
3. A method of reducing free radical damage comprising ingesting an effective dose of silica hydride mineral.
4. A method of enhancing mitochondrial bioenergetic capacity comprising ingesting an effective dose of silica hydride mineral.
5. A method of increasing antioxidant activity comprising ingesting an effective dose of silica hydride mineral.
6. A method of making water more suitable for conversion into optimal extracellular and intracellular body fluids comprising ingesting water mixed with an effective dose of silica hydride mineral.
7. A method of improving the characteristics of body fluids, such as saliva pH, saliva rH2, blood resistivity, urine resistivity, urine pH, urine rH2, and saliva resistivity comprising ingesting an effective dose of silica hydride mineral.

SOME BENEFITS OF MEGAHYDRATE INDICATED BY SCIENTIFIC STUDIES

  • Contains Hydrating Silica Microclusters®
  • Extremely Powerful Antioxidant
  • Recycles other Key Antioxidants in the Body
  • Extremely Safe and Non-Toxic
  • Easily Accesses All Cells in the body
  • Increases Cellular ATP Production by up to a factor of 4 times
  • Readily Converts NAD+ to NADH
  • Reduces Pain & Inflammation
  • Exhibits Powerful Anti-Aging Properties
  • Protects and Repairs DNA
  • Neutralizes Harmful Toxins like Fluoride, Chlorine, etc.
  • Protects Against and Repairs Radiation Damage
  • Increases Absorption of other Supplements
  • Lowers surface tension of water you drink leading to improved detoxification
  • Removes Heavy Metals from the Body
  • Balances pH or Alkalizes the body
  • Increases Zeta Potential of Human Cells
  • Increases Cellular Hydration
  • Very Stable – Works Over Extensive Time Periods
  • Reduces Lactic Acid Buildup During Intense Workouts
  • Protects Telomeres by allowing cells to exceed the Hayflick limit by 4-5 times

ADDITIONAL RESOURCES

Molecular Hydrogen Foundation (MHF)

Hydrogen for Optimal Health
by Fred Liers, PhD (from the HPDI blog)

Wonders of Molecular Hydrogen
by Fred Liers, PhD (from the HPDI blog)

Molecular Hydrogen (H2) at the Forefront of Health Research
by Hank Liers, PhD (from the HPDI blog)

ACTIVE H2 (tablet)

H2BEV (bottle)

MegaHydrate™ (capsule)

Contact Us:

You can reach HPDI by calling 1-800-228-4265, email support(at)IntegratedHealth.com, or visit the retail website: www.IntegratedHealth.com

Health care professionals and retailers can apply for wholesale account, which includes access to the HPDI reseller website: www.HealthProductsDistributors.com

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ULTIMATE PROTECTOR INGREDIENTS – CRANBERRY

Hank Liers cranberries cranberry ultimate protector Nrf2Ultimate Protector™ contains freeze dried cranberry, as well as components from 29 different fruits, vegetables, and herbs. Each of these ingredients contain substances that may be considered to be polyphenols, antioxidants, and Nrf2 activators. In this article I explore the ingredient strawberries, which is a component of VitaBerry Plus® from Futureceuticals.

VITABERRY PLUS®

VitaBerry® (N1023) is the trade name for a line of high ORAC blends of fruit powders and fruit extracts, exclusively available through FutureCeuticals.

VitaBerry® is a proprietary formula that combines wild bilberry and wild blueberry, cranberry, raspberry, strawberry, prune, cherry, and grape whole powders and extracts into lines of custom blends. High in fruit polyphenols, anthocyanins, proanthocyanins, ellagic acid, chlorogenic acid, resveratrol, and quinic acid, VitaBerry offers 6,000 ORAC units in a single gram.

VitaBerry® Plus (N81.3) combines the standard blend of VitaBerry® with resveratrol and quercetin to deliver a minimum of 12,000 ORAC units per gram.

Cranberry

Cranberries

HEALTH BENEFITS OF CRANBERRIES

Cranberries (Vaccinium macrocarpon) are native to the boggy regions of temperate and subalpine North America and Europe. Although Native Americans used them extensively, they were first cultivated in the U.S. in the early 19th century. Cranberries grow on viney plants belonging to the heath family Ericaceae that also includes blueberries, bilberries, huckleberries, and bearberries (Arctostaphylos uva ursi). Cranberries contain tannins, fiber, anthocyanins (and other flavonoids), and Vitamin C. Their tannins prevent bacteria from attaching to cells. Consequently, cranberries have been used against infections, including urinary tract infections. In addition, cranberries may be helpful in protecting against heart disease and stroke.

Cranberries are an especially good source of antioxidant polyphenols. In animal studies, the polyphenols in cranberries have been found to decrease levels of total cholesterol and so-called “bad” cholesterol. Cranberries may also inhibit the growth of tumors in human breast tissue and lower the risk of both stomach ulcers and gum disease. 

Here is a list of the antioxidant and anti-inflammatory phytonutrients in found in cranberries.

Type of Phytonutrient             Specific Molecules
Phenolic Acids                             hydroxybenzoic acids including vanillic acids;
—Phenolic Acids (cont.)             hydroxycinnamic acids inculding caffeic,
—Phenolic Acids (cont.)             coumaric, cinnamic, and ferulic acid
Proanthocyanidins                     epicatechins
Anthocyanins                              cyanidins, malvidins, and peonidins
Flavonoids                                   quercetin, myricetin, kaempferol
Triterpenoids                              ursolic acid

Other Cranberry Information

  • Cranberries hold significantly high amounts of phenolic flavonoid phytochemicals called oligomeric proanthocyanidins (OPC’s). Scientific studies have shown that consumption of the berries have potential health benefits against cancer, aging and neurological diseases, inflammation, diabetes, and bacterial infections.
  • Antioxidant compounds in cranberries including OPC’s, anthocyanidin flavonoids, cyanidin, peonidin and quercetin may prevent cardiovascular disease by counteracting against cholesterol plaque formation in the heart and blood vessels. Further, these compounds help the human body lower LDL cholesterol levels and increase HDL-good cholesterol levels in the blood.
  • Scientific studies show that cranberry juice consumption offers protection against gram-negative bacterial infections such as E.coli in the urinary system by inhibiting bacterial-attachment to the bladder and urethra.
  • In is known that cranberries turns urine acidic. This, together with the inhibition of bacterial adhesion helps prevent the formation of alkaline (calcium ammonium phosphate) stones in the urinary tract by working against proteus bacterial-infections.
  • In addition, the berries prevent plaque formation on the tooth enamel by interfering with the ability of the gram-negative bacterium, Streptococcus mutans, to stick to the surface. In this way cranberries helps prevent the development of cavities.
  • The berries are also good source of many vitamins like vitamin C, vitamin A, ß-carotene, lutein, zea-xanthin, and folate and minerals like potassium, and manganese.
  • Oxygen Radical Absorbance Capacity (ORAC) demonstrates cranberry at an ORAC score of 9584 µmol TE units per 100 g, one of the highest in the category of edible berries.

For more information on cranberries visit the sites given below:
https://www.healthambition.com/health-benefits-of-cranberry-juice/
or
http://www.whfoods.com/genpage.php?tname=foodspice&dbid=145

Scientific Studies on the Antioxidant Effects of Cranberry

Below, I provide relevant scientific studies on the antioxidant effects and potential health benefits of cranberries.

Prevention of oxidative stress, inflammation and mitochondrial dysfunction in the intestine by different cranberry phenolic fractions.

Abstract

Cranberry fruit has been reported to have high antioxidant effectiveness that is potentially linked to its richness in diversified polyphenolic content. The aim of the present study was to determine the role of cranberry polyphenolic fractions in oxidative stress (OxS), inflammation and mitochondrial functions using intestinal Caco-2/15 cells. The combination of HPLC and UltraPerformance LC®-tandem quadrupole (UPLC-TQD) techniques allowed us to characterize the profile of low, medium and high molecular mass polyphenolic compounds in cranberry extracts. The medium molecular mass fraction was enriched with flavonoids and procyanidin dimers whereas procyanidin oligomers (DP > 4) were the dominant class of polyphenols in the high molecular mass fraction. Pre-incubation of Caco-2/15 cells with these cranberry extracts prevented iron/ascorbate-mediated lipid peroxidation and counteracted lipopolysaccharide-mediated inflammation as evidenced by the decrease in pro-inflammatory cytokines (TNF-α and interleukin-6), cyclo-oxygenase-2 and prostaglandin E2. Cranberry polyphenols (CP) fractions limited both nuclear factor κB activation and Nrf2 down-regulation. Consistently, cranberry procyanidins alleviated OxS-dependent mitochondrial dysfunctions as shown by the rise in ATP production and the up-regulation of Bcl-2, as well as the decline of protein expression of cytochrome c and apoptotic-inducing factor. These mitochondrial effects were associated with a significant stimulation of peroxisome-proliferator-activated receptor γ co-activator-1-α, a central inducing factor of mitochondrial biogenesis and transcriptional co-activator of numerous downstream mediators. Finally, cranberry procyanidins forestalled the effect of iron/ascorbate on the protein expression of mitochondrial transcription factors (mtTFA, mtTFB1, mtTFB2). Our findings provide evidence for the capacity of CP to reduce intestinal OxS and inflammation while improving mitochondrial dysfunction.

 Chemical characterization and chemo-protective activity of cranberry phenolic powders in a model cell culture. Response of the antioxidant defenses and regulation of signaling pathways

Abstract

Oxidative stress and reactive oxygen species (ROS)-mediated cell damage are implicated in various chronic pathologies. Emerging studies show that polyphenols may act by increasing endogenous antioxidant defense potential. Cranberry has one of the highest polyphenol content among commonly consumed fruits. In this study, the hepato-protective activity of a cranberry juice (CJ) and cranberry extract (CE) powders against oxidative stress was screened using HepG2 cells, looking at ROS production, intracellular non-enzymatic and enzymatic antioxidant defenses by reduced glutathione concentration (GSH), glutathione peroxidase (GPx) and glutathione reductase (GR) activity and lipid peroxidation biomarker malondialdehyde (MDA). Involvement of major protein kinase signaling pathways was also evaluated. Both powders in basal conditions did not affect cell viability but decreased ROS production and increased GPx activity, conditions that may place the cells in favorable conditions against oxidative stress. Powder pre-treatment of HepG2 cells for 20 h significantly reduced cell damage induced by 400 μM tert-butylhydroperoxide (t-BOOH) for 2 h. Both powders (5–50 μg/ml) reduced t-BOOH-induced increase of MDA by 20% (CJ) and 25% (CE), and significantly reduced over-activated GPx and GR. CE, with a significantly higher amount of polyphenols than CJ, prevented a reduction in GSH and significantly reduced ROS production. CJ reversed the t-BOOH-induced increase in phospho-c-Jun N-terminal kinase. This study demonstrates that cranberry polyphenols may help protect liver cells against oxidative insult by modulating GSH concentration, ROS and MDA generation, antioxidant enzyme activity and cell signaling pathways.

Cranberry extract suppresses interleukin-8 secretion from stomach cells stimulated by Helicobacter pylori in every clinically separated strain but inhibits growth in part of the strains

From: http://www.sciencedirect.com/science/article/pii/S1756464613000364

Abstract

It is known that cranberry inhibits the growth of Helicobacter pylori (HP). In human stomach, HP basically induces chronic inflammation by stimulating stomach cells to secrete interleukin (IL)-8 and other inflammatory cytokines, and causes stomach cancer, etc. The aim of this study was to investigate the inhibiting effects of cranberry on HP growth and IL-8 secretion from stomach cells induced by HP, using clinically separated HP strains. HP growth in liquid culture and on-plate culture was evaluated by titration after 2-day incubation and by agar dilution technique, respectively. For IL-8 experiments, MKN-45, a stomach cancer cell line, was incubated with HP for 24 h and IL-8 in the medium was assayed by ELISA. Cranberry suppressed growth of the bacteria only in six of the 27 strains. Meanwhile, it suppressed IL-8 secretion in all the strains. The results may suggest a possible role of cranberry in prevention of stomach cancer by reducing gastric inflammation.

Effects of cranberry powder on biomarkers of oxidative stress and glucose control in db/db mice

From: http://www.ncbi.nlm.nih.gov/pubmed/24353827

Abstract

Increased oxidative stress in obese diabetes may have causal effects on diabetic complications, including dyslipidemia. Lipopolysccharides (LPS) along with an atherogenic diet have been found to increase oxidative stress and insulin resistance. Cranberry has been recognized as having beneficial effects on diseases related to oxidative stress. Therefore, we employed obese diabetic animals treated with an atherogenic diet and LPS, with the aim of examining the effects of cranberry powder (CP) on diabetic related metabolic conditions, including lipid profiles, serum insulin and glucose, and biomarkers of oxidative stress. Forty C57BL/KsJ-db/db mice were divided into the following five groups: normal diet + saline, atherogenic diet + saline, atherogenic diet + LPS, atherogenic diet + 5% CP + LPS, and atherogenic diet + 10% CP + LPS. Consumption of an atherogenic diet resulted in elevation of serum total cholesterol and atherogenic index (AI) and reduction of high density lipoprotein (HDL)-cholesterol. However, with 10% CP, the increase in mean HDL-cholesterol level was close to that of the group with a normal diet, whereas AI was maintained at a higher level than that of the group with a normal diet. LPS induced elevated serum insulin level was lowered by greater than 60% with CP (P < 0.05), and mean serum glucose level was reduced by approximately 19% with 5% CP (P > 0.05). Mean activity of liver cytosolic glutathione peroxidase was significantly increased by LPS injection, however it was reduced back to the value without LPS when the diet was fortified with 10% CP (P < 0.05). In groups with CP, a reduction in mean levels of serum protein carbonyl tended to occur in a dose dependent manner. Particularly with 10% CP, a reduction of approximately 89% was observed (P > 0.05). Overall results suggest that fortification of the atherogenic diet with CP may have potential health benefits for obese diabetes with high oxidative stress, by modulation of physical conditions, including some biomarkers of oxidative stress.

Ultimate Protector cranberry cranberries

SUMMARY

Cranberries are an important fruit full of polyphenols, anthocyanins, antioxidants, and Nrf2 activators that help to make Ultimate Protector such an outstanding nutritional supplement.

ADDITIONAL RESOURCES

 

Contact Us:

You can reach HPDI by calling 1-800-228-4265, email support(at)IntegratedHealth.com, or visit the retail website: www.IntegratedHealth.com

Health care professionals and retailers can apply for wholesale account, which includes access to the HPDI reseller website: www.HealthProductsDistributors.com

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GUT FUNCTION BREAKTHROUGH – RESTORE

Dr Hank Liers PhD restore gut healthI have been excited about the ongoing research concerning the human biome ever since preparing my blog article entitled “A New View of the Role of Bacteria in Health” in June of 2012.

I was particularly impressed by a TED talk of Dr. Bonnie Bassler concerning how bacteria communicate with each other (“Discovering Bacteria’s Amazing Communication System“) on TED.com.

I came away from Dr. Bassler’s talk with a new understanding of who we are and how we are influenced by bacteria. The fact that our bodies house ten times the number of bacteria than the number of cells in our bodies and 100 times the amount of DNA compared to our human DNA is very impressive!! Of particular note was the fact that bacteria conduct both intraspecies and interspecies communication using carbon-based hormones.

TIGHT JUNCTIONS RESTORE GUT HEALTH

Since that time my company switched to a soil-based organisms (SBO) probiotic formula called Prescript-Assist as our main probiotic formula. The formula includes a “prebiotic” called leonardite.

Leonardite is a natural form of humates that is completely organic in nature and provides ideal conditions for “good” bacteria to grow. It is a soft, waxy, black or brown, shiny, vitreous mineraloid that is easily soluble in alkaline solutions.

Leonardite is an oxidation product of lignite, a soft, brown combustible sedimentary rock formed from naturally compressed peat. Lignite has a carbon content of 25–35% and embedded in the carbon are special carbon-based molecules that were produced by soil bacteria millions of years ago.

The amazing part of this story is that Dr. Zachary Bush—a medical doctor with extensive experience in cancer research and mitochondria chemistry—made an accidental and instant connection between the special carbon molecules of lignite and special redox molecules found in mitochondria.

Based upon his recognition of these similar molecules, he developed a formula using the lignite bacterial produced carbon molecules. He found that by adding certain trace minerals and amino acids under special conditions these carbon molecules were activated.

Upon giving his formula to human beings, Dr. Bush discovered dramatic and rapid increases in beneficial gut bacterial counts. That is, the human microbiome was significantly affected in a positive way. This is particularly important since it is known that the human gastrointestinal tract houses about seventy percent of our immune system.

restore gut health

The most amazing part of the story was then discovered. That is when the formula (called RESTORE) was given, the tight junctions in the gut were restored to their optimal condition and “leaky gut” disappeared.

What makes this discovery so special is that “leaky gut” is caused by certain toxic bacteria, gluten, antibiotics, medical anti-inflammatories, and especially the herbicide glyphosate (RoundUp) used for genetically modified (GMO) food crops. This “leaky gut” condition is endemic in our society and getting worse as we continue to take in these toxic substances in ever increasing amounts. In Dr. Bush’s experience with a very broad range of conditions, healing began to occur very quickly when RESTORE is taken.

Additionally, Dr. Bush found that when the tight junctions in the gut were restored to their optimal condition, all of the other tight junctions in the body were restored as well. These include tight junction in the blood brain barrier, the kidney tubules, blood vessels, etc. As a result many conditions in the body dramatically improved.

Dr. Bush discovered that almost all conditions of poor health are caused by chronic inflammation and he has stated that chronic inflammation is caused by a lack of communication within the cells of the body. He has clearly seen that RESTORE reinstates proper communication between the cells and greatly reduces inflammatory conditions!

HOW EXCITING!!! Based upon this almost unbelievable discovery we have decided to carry RESTORE in both 32 oz and 8 oz sizes on our retail website. We take it ourselves!!!

To learn more about RESTORE and its discovery listen to this talk by Dr. Bush.

 

Contact Us:

You can reach HPDI by calling 1-800-228-4265, email support(at)IntegratedHealth.com, or visit the retail website: www.IntegratedHealth.com

Health care professionals and retailers can apply for wholesale account, which includes access to the HPDI reseller website: www.HealthProductsDistributors.com