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What I’d Really Love to Tell You About the Methylation Cycle

Dr. Hank Liers, PhD geneticsI previously published “Homocysteine Genetics – Coenzyme B Vitamins” in which I considered in-depth how homocysteine (an intermediate chemical in the Methylation Cycle) is formed from methionine, how genetics affects the metabolic pathways, and how B vitamins are used in metabolic pathways. I also wrote “Folate Ingredients – Folinic Acid & 5-MTHF” which discussed how coenzyme folate vitamins are far superior to the synthetic folic acid form. In today’s article, I take a broader view of the topic that encompasses the Methylation Cycle, genetics, and B vitamins.

THE METHYLATION CYCLE

The Methylation Cycle is considered to be one of the most important metabolic pathways in the human body. Its most important function is to provide methyl groups via SAM (S-adenosyl methionine) to hundreds of different body substrates. Methylation is continually occurring in the body, transforming many millions of molecules throughout the body every second. Molecules receive methyl groups, then separate and recombine continuously, transforming and reforming constantly in the ongoing process of life!

As a reminder of the pathways involved in the Methylation Cycle, the following figure provides a flow chart showing the details.

 

Methylation Cycle

Figure 1. Metabolic Pathways in Methylation Cycle

A key purpose of this cycle is to provide methyl groups (CH3) needed by a broad range of of body functions (over 200 different functions). Examples include:

  1. Influences the genetic expression that parents give their children and helps guide the development of the embryo.
  2. Is needed by the nervous system to produce neurotransmitters and maintain the nerves.
  3. Mobilizes fats and cholesterol so they do not accumulate where they are harmful, such as the arteries and liver.
  4. Regulates hormones, including, estrogen, adrenaline, and melatonin.
  5. Detoxifies harmful chemicals and histamine a prime substance involved in inflammation.
  6. Helps repair damaged proteins in the cells so they can function properly.
  7. Protects the DNA in the genome (genetic code) to reduce the chances of mutation.
  8. Creates antioxidants used in the antioxidant defense system.

DESCRIPTION OF PATHWAYS WITHIN THE METHYLATION CYCLE

The overall flow of the Methylation Cycle begins with dietary methionine (an essential amino acid) which combines with ATP (adenosine triphosphate – body energy) to form SAM (S-adenosyl methionine) – the common cosubstrate involved in methyl group transfers, transsulfuration, and aminopropylation. When SAM transfers a methyl group to a body chemical the residue from this reaction leads to the production of homocysteine.

Homocysteine can be converted in the transsulfuration pathway that requires coenzyme vitamin B6 to produce cysteine, glutathione, taurine, and sulfates. These sulfur containing substances provide important antioxidant protection and detoxification functions in the body.

Homocysteine can be converted back to methionine through the betaine (trimethyl glycine) pathway which requires zinc and magnesium. This pathway also requires dietary betaine or choline which the body can convert into betaine.

Also, homocysteine can be converted back to methionine via the remethylation pathway which requires 5-MTHF, coenzyme vitamin B2 and methylcobalamin (B12).

GENETICS

It is important to understand that each of the pathways described above are able to be executed only in the presence of enzymes (shown in blue boxes in the diagram) created by specific genes in your genetic code. For example, Betaine-Homocysteine S-Methyltransferase (BHMT) is the enzyme required in the betaine pathway, Cystathione Beta Synthase (CBS) is the enzyme required in the transsulfuration pathway, and Methylenetetrahydrofolate Reductase (MTHFR) and Methionine Synthase (MS) are enzymes required in the remethylation pathway.

Assuming that you have perfect genetics (no mutations, SNPs, free radical damage, insertions/deletions, etc.), the proper functioning of these pathways are still subjected to the fact that the required vitamins and minerals (vitamin B6, vitamin B2, Folate, vitamin B12, zinc, magnesium, and betaine) need to be provided by your diet or from supplements for the body to function correctly.

In addition, exposure to high levels of toxins from your environment and high levels of stress require that the nutritional needs will be even higher for the pathways to work properly. For example, exposure to high levels of toxins requires that the transsulfuration pathway be more active possibly reducing the amount of available methionine to support necessary methyl transfer reactions.

For these reasons alone the consensus of knowledgeable practitioners is that you should be eating an organic whole foods diet, taking appropriate nutritional supplements, avoiding and eliminating toxins from food, water, and air (living in a clean environment), and avoiding an unduly stressful life. All of these actions fall into the category of Epigenetics which you generally have control over!! Doing these things alone could significantly balance the functioning of your Methylation Cycle and improve your health.

Unfortunately, few people have perfect genetics which often causes the various pathways in the Methylation Cycle to become imbalanced and unable to correct the dysregulation imposed upon the body. For example, the enzyme MTHFR can have heterozygous (single chromosome) genetic variations in up to 50% of certain populations and homozygous genetic variations (both chromosomes) in 10% or more of certain populations.

Some disorders that researchers have associated with MTHFR genetic variations include:

  • Alzheimer’s disease
  • Asthma
  • Atherosclerosis
  • Autism
  • Bipolar disorder
  • Bladder issues
  • Blood clots
  • Breast problems
  • Chemical sensitivity
  • Chronic fatigue syndrome
  • Down syndrome
  • Epilepsy
  • Fibromyalgia
  • Gastric problems
  • Glaucoma
  • Heart murmurs
  • High blood pressure
  • Irritable bowel syndrome
  • Leukemia
  • Male infertility
  • Methotrexate toxicity
  • Migraines with aura
  • Multiple sclerosis
  • Myocardial infarction
  • Nitrous oxide toxicity
  • Parkinson’s disease
  • Pulmonary embolisms
  • Schizophrenia
  • Stroke
  • Thyroid issues
  • Unexplained neurologic disease
  • Vascular dementia

This extensive list is highly significant and tells us that it is very important to have genetic testing done for the genes/enzymes in the Methylation Cycle pathway. I prefer the BodySync genetic test which evaluates the key Methylation Cycle genes plus many other important genes in a single test.

B VITAMINS AND MINERALS

We are strong believers that everyone should start their nutritional program by eating a balanced, organic, whole foods diet. We have been doing this ourselves for the past 30 years. Unfortunately, only a small percentage of people follow this advice and in most cases this leads to poor nutritional status that does not adequately support the body’s needs. This is especially true with respect to obtaining the nutrients needed to support the Methylation Cycle.

Nine of our family members and associates have taken the BodySync genetic test which evaluates the condition of 45 different enzymes including CBS, MTHFR (2 variations), MTR (related to B12 and 5-MTHF as they relate to methionine synthase – MS), and MTRR (related to maintaining B12 levels needed by the MTR enzyme). In every case the results showed at least 2 and up to 4 enzymes had genetic variations. These results indicate that the nutritional requirements for folate as 5-MTHF, vitamin B12 as methylcobalamin, vitamin B6, vitamin B2, magnesium and zinc will likely be significantly greater than normal.

Given the above information, it seems essential for good health to take nutritional supplements that provide the important nutrients. Below I will discuss various formulas that I have developed and refined over many years that are useful especially for the Methylation Cycle.

Please note that Health Products Distributors, Inc. (HPDI) is the preferred supplier of nutritional supplements by the BodySync genetic testing company.

MULTIVITAMINS

When looking at the total needs the body has for nutrients that the body does not produce, including fat soluble vitamins (A, D (some), E, K1 and K2), vitamin C, B vitamins (B1, B2, B3, B5, B6, folate, B12, biotin, choline, and inositol), minerals (Ca, Mg, Zn, Se, Cu, Mn, Cr, Mo, K, boron, and vanadium), and betaine it only seems wise to include as a top priority a Multivitamin that includes all of these in what I term therapeutic amounts (carefully selected after evaluating thousands of research studies carried out over many years.)

In this context, it is important to recognize that every enzymatic reaction in the body requires mineral cofactors in order to carry out its function. A good multivitamin provides many of these required minerals.

Additionally, the multivitamin should contain ingredient forms that research has confirmed to be the most absorbable and usable by the body. These include coenzyme B vitamins, Krebs cycle (citrate, alpha-ketoglutarate, succinate, fumarate, & malate) minerals, and amino acid chelates.

In the context of supporting the Methylation Cycle we are looking for specific forms and amounts of B vitamins that can adequately provide the body’s needs. The means that there should be coenzyme folate as 5-MTHF of at least 400 mcg, coenzyme vitamin B-12 as methylcobalamin of at least 200 mcg, Vitamin B6 (including significant amounts of pyridoxal 5′ phosphate) of at least 40 mg, and Vitamin B2 (including significant amounts of riboflavin 5′ phosphate) of at least 25 mg. In addition, magnesium (100 mg) and zinc (at least 20 mg) should be provided.

Please note that the body’s requirements for magnesium is generally accepted by nutritional experts to be higher than 400 mg daily (and as high as 1,000 mg daily). For this reason we generally recommend that a person take supplemental magnesium (such as HPDI’s MYO-MAG) at levels over 400 mg daily.

The two multivitamin formulas Health Products Distributors provides for adults that meet these requirements (and more) are the Hank & Brian’s Mighty Multi-Vite and Multi Two (in both capsule and tablet forms). Click on the bottles below for technical details.

Hank & Brian's Mighty Multi-Vite multivitamin methylation cycle

Multi Two Caps or Tablets methylation cycle

B COMPLEX

In situations where significant genetic variations are present it may be wise to add a B COMPLEX supplement to the MULTIVITAMIN to provide even larger amounts of the needed B vitamins. HPDI provides a B-Complex-50 product that includes significant amounts of coenzyme forms and contains 50 mg of Vitamin B1, 50 mg of Vitamin B2, 100 mg of Vitamin B3, 50 mg of Vitamin B6, 500 mcg of coenzyme folate (both folinic acid and 5-MTHF), 100 mcg of B12 (both methylcobalamin and hydroxocobalmin), 50 mg of Vitamin B5 (pantothenic acid), 500 mg of Biotin, 50 mg of choline, and 50 mg of inositol. Click on the bottle below for technical details.

B-Complex-50 full spectrum B vitamins with coenzyme forms methylation cycle

FOLATE AS 5-MTHF

In situations where an inadequate diet is present and genetic testing indicates an MTHFR variation (especially a homozygous variation) Health Products Distributors provides a 5-MTHF folate supplement that easily absorbs into the body and can be directly used in combination with Vitamin B12 to convert homocysteine to methionine. Click on the bottle below for technical details.

5-MTHF 1 mg in veggie cap methylation cycle

5-MTHF 1 mg in veggie cap

B-12 as METHYLCOBALAMIN

It is often the case for older patients and vegetarians that Vitamin B12 is deficient. In these cases it is wise to supplement with a significant amount of methylcobalamin to ensure that the Methylation Cycle has sufficient to effectively convert homocysteine into methionine. Health Products Distributors Vitamin B12 contains 5 mg of methylcobalamin in sublingual lozenge form that supports excellent absorption even if swallowed and absorbed by diffusion. Click on the bottle below for technical details.

Vitamin B-12 5 mg methylcobalamin sublingual lozenge methylation cycle

Vitamin B-12 – 5 mg Methylcobalamin sublingual lozenge.

MINERALS

Magnesium and zinc are two important minerals used in the betaine pathway of the Methylation Cycle in which homocysteine is converted back to methionine.

In the body magnesium is involved in more than 400 essential metabolic reactions and is required by the adenosine triphosphate (ATP)-synthesizing protein in mitochondria. ATP, the molecule that provides energy for almost all metabolic processes, exists primarily as a complex with magnesium (MgATP). Therefore, it also is involved in converting methionine to SAM.

Over 300 different enzymes depend on zinc for their ability to catalyze vital chemical reactions. Zinc-dependent enzymes can be found in all known classes of enzymes.

Health Products Distributors provides 100 mg magnesium/vcap in its MYO-MAG supplement which is especially important in increasing ATP in the Krebs Cycle. This product also contains vitamin B1, vitamin B2, and vitamin B6 with substantial amounts of coenzyme forms and manganese. Click on the bottle below for technical details.

MYO-MAG with 100 mg magnesium per serving key B vitamins methylation cycle

MYO-MAG with 100 mg magnesium per serving and key B vitamins.

Health Products Distributors provides 25 mg zinc/serving in its Double Zinc Plus supplement. This formula provides zinc in the picolinate and citrate forms as well as 3 mg of P5P (coenzyme B6). Click on the bottle below for technical details.

Double Zinc Plus supplement with P5P and 25 mg zinc methylation cycle

Double Zinc Plus supplement with P5P and 25 mg zinc

SUMMARY

The Methylation Cycle is recognized as one of the most important metabolic pathways in the human body. When not properly supported by key B vitamins and minerals, the Methylation Cycle can become severely imbalanced which can lead to a very wide range of poor health conditions. Furthermore, genetic variations in the genes that produce important enzymes allowing the Methylation Cycle to function correctly lead to even further imbalances and greater possibility for conditions of poor health.

In this article, I have provided insight into how the Methylation Cycle works and how it can be significantly supported by lifestyle changes regarding diet and environment (Epigenetics) and by specific B vitamins and mineral supplements that I have developed over many years. In addition, we have shown that knowledge gained from genetic testing can further provide a critical understanding of your specific needs so that your health can be optimized.

RELATED HPDI BLOG ARTICLES

Homocysteine Genetics – Coenzyme B Vitamins

 

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HOW TO MAKE KETO COFFEE USING pH ADJUST

Fred Liers PhD keto coffee pH Adjust alkalinizeWe can all stand to be more alkaline. The majority of people are acidic due to diet and lifestyle. One of the best formulas for creating alkalinity is pH Adjust. pH Adjust is a good-tasting, fluffy white powder that dissolves easily in water, juice, and yes, coffee.

Shortly after launching pH Adjust as a new product, we began receiving reports from customers that they used pH Adjust in their coffee.

Why put pH Adjust into coffee? Well, first it is a pleasant and convenient carrier for pH Adjust. Second, and most importantly, coffee is acid-forming in the body. By putting pH Adjust directly into coffee, you both can counteract acidity and simultaneously alkalinize the body.

My questions: Was coffee creating acid condition in my body? And would putting pH Adjust in my coffee make a a difference? Short answer: Yes.

I enjoy coffee. I don’t drink it all the time. But after hearing customer comments, I decided to try pH Adjust in my coffee. Within a day or two, I noticed my teeth were stronger! This was welcome news.

In fact, I had been dealing with a few “minor” dental issues, including teeth chipping, enamel wear, and occasional tooth pain. My diet is good and I eat plenty of vegetables and fruits. So how could my teeth be compromised?

I measured my pH using Hydrion pH paper. It was lower than I thought it would be. Simply put: I was more acidic, more of the time, than I knew. Does acidity weaken teeth? Yes, it does.

ph Adjust keto coffee

pH Adjust alkalinizes the body rapidly. It dissolves easily in water, coffee & most drinks.

“Bicarbonate reserves” decline as we age. This makes us more acidic because we don’t buffer acidity as easily as we did when younger. The body must then draw upon minerals in bones and teeth. Yet, even young people are overly acidic in modern society. Everyone who is acidic stands to benefit from increased pH levels. That means most of us.

The proof that acidity causes weaker teeth is the fact that pH Adjust immediately stopped my tooth chipping, enamel wear, and pain. Good thing I put pH Adjust into coffee shortly after HPDI introduced it. And thanks to the customers, employees, and friends of HPDI who told me about it.

ALKALINIZING COFFEE IS HEALTHIER

Coffee with pH Adjust is healthier than plain coffee because it helps alkalinize the body. Taking pH Adjust (without coffee) accomplishes the same thing. But for those who enjoy coffee, adding pH Adjust is an easy way to alkalinize what can otherwise be an acidifying drink. Who wants acidity? Not me.

I now use pH Adjust in coffee by directly adding a 1/2 to 1 teaspoon directly into coffee and stirring. I adjust the dose according to how much coffee I drink.

I also take pH Adjust separately from coffee—usually once or twice daily—about one teaspoon per dose. Taking 1–2 teaspoons total of pH Adjust daily seems to be the right amount. I no longer have issues with my teeth. My bones feel stronger, too.

If you drink coffee, then adding pH Adjust to make it “pH Adjust coffee” may be helpful to you. It reduces acidity and supports mineral balance. It especially provides good levels of potassium and magnesium, minerals that are required for good health—and that are deficient in most people.

If coffee is driving acidity in your body, then pH Adjust may be just the thing for you. Putting pH Adjust in your coffee directly means stopping acidity at the source. pH Adjust dissolves easily in coffee (and most other drinks) and does not add a bad taste. In fact, many people, including me, enjoy the gently sweet flavor it imparts.

pH test paper litmus keto coffee

Test pH using Hydrion litmus paper.

KETOGENIC COFFEE WITH pH ADJUST

More recently, I discovered the benefits of using organic coconut or MCT oil in coffee with organic pasture butter or ghee. This is based on the concept of Bulletproof coffee popularized by Dave Asprey in his Bulletproof Diet, and it fits well into ketogenic diets. Ketogenic diets are low in carbohydrates, high in fats, and include plenty of high-quality protein.

I do not follow a ketogenic diet per se. Yet, I consume relatively high amounts of “good” fats (like coconut, olive, and avocado oils) and few simple carbohydrates. I had even added coconut oil, butter, and ghee into my coffee years ago. But I never blended it into an emulsified concoction, nor was pH Adjust available. So this is truly different!

MAKE KETO COFFEE

I make ketogenic or “keto” coffee using freshly ground organic coffee, organic coconut oil and/or organic MCT oil, and organic unsalted ghee (or pasture butter). It is important the ingredients be organic and pasture fed when possible.

I first brew the coffee, then add coconut oil or MCT oil, and butter or ghee. Then I use a hand blender (or regular blender) to mix completely.

INGREDIENTS

• 8–16 ounces freshly brewed coffee

• 1–2 tablespoons of Coconut oil or MCT oil

• 1 teaspoon–2 tablespoons of unsalted ghee (or unsalted pasture butter)

• 1/2 tsp–2 teaspoons pH Adjust (to taste, depending on quantity desired)

Put freshly brewed coffee in a blender or large container (like a mason jar). Add coconut oil/MCT oil, ghee, and pH Adjust. Blend or use hand blender to mix well. It is important the coffee be hot (or at least warm) in order for the coconut/MCT oil and ghee to mix into it.

You can add the pH Adjust either before or after you mix or blend the coffee. I personally stir in the pH Adjust manually using a long spoon after I’ve already mixed the other ingredients. If you add the pH Adjust after mixing the other ingredients, then be sure to stir well.

Note on amounts: the amounts I list above are suggestions. I often use less coconut or MCT oil, or ghee. That is, some days I use just two teaspoons of coconut/MCT oil, or one rounded teaspoon of ghee. Try using different amounts of ingredients to see what works for you.

Keto Coffee Ghee Butter

Grass-fed ghee is a key ingredient in keto coffee.

One reason for using less coconut/MCT oil or ghee is because this coffee can be “filling.” I am not hungry after I drink it. This is one benefit according to keto coffee experts. In fact, it is recommended that users drink it in the morning before eating. This gives the option of putting off breakfast.

If I have planned to eat breakfast, then I will often use less coconut or MCT oil. The lower level of satiety from the coffee means I eat breakfast without having already been filled by the keto coffee.

Make keto coffee any time of day. It is probably best on an empty stomach and definitely not too late into the afternoon—unless you want to be up late (if coffee affects you that way). You can make it early in the day, and then consume it over the course of the morning and afternoon.

Benefits of Coffee or Keto Coffee with pH Adjust

• Alkalinizes body — an alkaline state is good for overall health

• Provides minerals, especially potassium and magnesium

• May help strengthen teeth and bones

• Some users report improved digestion

• Some users report reduced GERD

• Some users report less Restless Leg Syndrome (RLS)

• Potassium helps balance out sodium — and is required for cellular health

• Magnesium is essential for 400 enzyme systems, production of ATP, cardiovascular health, and muscle relaxation

• Many other benefits!

There are many other benefits associated with an alkaline state, which is ideally a pH of 7.35–7.45. You can learn more about the benefits of alkalinization from earlier HPDI blog articles (see resources section below), doing web searches, or talking to your health professional.

If these benefits are not sufficient reason to try using pH Adjust in your coffee to make “pH Adjust alkalinizing coffee” then consider doing it for the taste!

Tip: To make this coffee more hydrating, try adding 8-16 drops of Patrick Flanagan’s Crystal Energy, which makes the water in this drink more bioavailable.

keto coffee ingredients MCT oil ghee

KETO COFFEE TASTES GOOD

Keto coffee tastes good. The oils and fats provide a rich, hearty taste. It is creamy, warm, and delicious. And as I mentioned, it is filling, so it satisfies hunger.

Adding pH Adjust to keto coffee won’t change the taste much. In fact, many people say adding pH Adjust makes it taste better. I agree. This may be due to the fact that the formula contains glycine in the form of potassium glycinate. Glycine tastes good and is naturally “sweet” without the harmful effects of sugar. In fact, to me pH Adjust imparts a slightly sweet flavor that is reminiscent of “caramel.”

pH Adjust may slightly change the texture of your coffee. It may make regular, non-keto coffee appear and taste “creamier.” Most people won’t mind that. As for keto coffee, it is already “creamy” due to the coconut/MCT oil and ghee. pH Adjust might just add a bit more texture to it.

Also, there may be a slight chalky, white residue at the bottom of your cup. This does not happen if you mix in the pH Adjust formula well, or if you re-stir (or swirl) the coffee cup or glass when it’s half full. Remember: if you see this residue, it is pH Adjust. As such, you may wish to drink it as is, or add little more liquid (coffee, water, etc.) and quaff it down.

keto coffee blender drink

Mix the MCT or coconut oil and ghee (or butter) using a blender or stick blender.

DRINK pH ADJUST FOR ALKALINITY

To me, the most important thing about coffee or keto coffee with pH Adjust is not how it tastes or how it reduces hunger, etc. It is how is increases pH levels. Alkalinity is important for health. No matter how you choose to take or drink it, pH Adjust will alkalinize. In spades.

Besides coffee, you can add pH Adjust to juices, teas, smoothies, shakes, water, and even lemonade. The fact is, taking pH Adjust is more important than the drink you choose to take it with. You decide the drink.

That being said, I really like keto coffee with pH Adjust. I add ice for a delightful, cooling concoction in summer. In winter, I drink it hot.

I think you will enjoy keto coffee with pH Adjust, too. And, if you already brew and drink your own version of keto coffee, then increased alkalinity—and better health—is as simple as adding a spoonful of pH Adjust. ~

RESOURCES

HPDI BLOG ARTICLES

Alkalizine with Lemonade Diet and pH Adjust

Got Potassium?

Racing and Recovery with pH Adjust Alkalinizing Formula

Alkalinize Rapidly Using pH Adjust

pH Adjust Alkalinizing Formula – New Product!

BOOKS & ARTICLES

Acid-alkaline balance: role in chronic disease and detoxification
(Altern Ther Health Med, 13(4):62-5)

Acid & Alkaline by Herman Aihara

Bicarb Magical Mineral Supplement by Dr. Mark Sircus, Ac, OMD

The Bulletproof Diet by Dave Asprey

Head Strong by Dave Asprey

The High Blood Pressure Solution by Richard D. Moore, MD, PhD

The K Factor: Reversing and Preventing High Blood Pressure without Drugs by Richard D. Moore, MD, PhD

Keto: The Complete Guide to Success on The Ketogenic Diet by Maria Emmerich

Simply Keto: A Practical Approach to Health & Weight Loss by Suzanne Ryan

The XXL Syndrome by Max Rombi, MD

LISTS & REFERENCE

The Acid Alkaline Food Guide
by Dr. Susan Brown and Larry Trieviei, Jr.

Potassium Intake of the US Population (PDF)
(NHANES Food Surveys Research Group, USDA)

Potassium: Health Benefits, Recommended Intake

List of acid-forming and alkaline forming foods

PRODUCTS

pH Adjust
(Dr. Hank Liers’ original formula)

pH paper (roll)
(Hydrion litmus paper)

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HYDROGEN SUPPLEMENTS – ACTIVE H2 ULTRA and MEGAHYDRATE

Fred Liers PhD hydrogen supplements Active H2 Ultra MegahydrateSupplemental hydrogen is fast becoming essential in many people’s nutritional supplement regimens. Why? Because hydrogen offers significant health benefits, including excellent antioxidant protection, increased energy, faster recovery, and improved well-being. Who doesn’t want those benefits?

My favorite way to take hydrogen is to make hydrogen-infused water, or what I call a hydrogen “fizzy” drink. Two products I like best are Active H2 Ultra tablets and Megahydrate (available in powder and capsules). Active H2 Ultra provides molecular hydrogen (H2) and Megahydrate provides hydride (H-). Both are great standalone formulas, yet work well together as each provides unique means to quench free radicals effectively.

MAKE “FIZZY” HYDROGEN-INFUSED WATER WITH ACTIVE H2 ULTRA

Drinking H2-rich water is an easy and effective method for obtaining hydrogen, according to the Molecular Hydrogen Foundation. Making hydrogen-infused water is simple and convenient, as you can drink it at home or while traveling. Effective hydrogen products HPDI carries include Active H2 Ultra tablets, Megahydrate powder, and Megahydrate capsules.

My favorite hydrogen drink contains both Active H2 Ultra and Megahydrate. I take these products separately at times, but find it easier to take them together—and gain the benefits of both immediately.

Active H2 Ultra Megahydrate

Active H2 Ultra tablets and Megahydrate powder work together for major antioxidant power.

INGREDIENTS – HYDROGEN-INFUSED WATER

• 1 Scoop Megahydrate powder (500 mg) or 1 Megahydrate capsule (600 mg)

• 1 Tablet of Active H2 Ultra

• 8–16 Ounces of Purified Water

DIRECTIONS: Put one scoop of Megahydrate powder (or open one capsule) into your container of water. Let sit for about 30–60 seconds. Drop in one Active H2 Ultra tablet. Allow it to effervesce for one minute or until fully dissolved. Drink immediately. For best assimilation, preferably take on an empty stomach at least 10–15 minutes before food. Wait one hour after eating to drink hydrogen-infused water.

Note: Do not wait long after effervesce stops to drink the water because hydrogen will escape into the air. Alternatively you can cap the container with a lid, and this will allow the hydrogen to last a while longer.

Molecular hydrogen is sufficiently small to pass through glass, so use a metal container if you plan to cap it. If you drink immediately, then the type container you use won’t matter. I personally prefer a glass mason jar. This allows me to see the tablet dissolve, but also means drinking it immediately.

I make 1–3 hydrogen fizzy drinks daily, first in the morning and then in the afternoon, but almost never in the evening as it can be energizing. I drink hydrogen water on an empty stomach. I gain a significant energy boost, but also other benefits, including improved athletic performance, faster recovery from exercise, and an overall greater sense of well-being.

I highly recommend you try hydrogen supplements for yourself, and then consider them for your clients or patients. Our experience is that most people are pleasantly surprised by the results they get from hydrogen supplements, especially if they have a need for exceptional free-radical defense, or stand to benefit from the proven effects of hydrogen (see list below).

You will want to continue taking hydrogen supplements regularly because the benefits are so significant, especially over time. Let the power of hydrogen starting working for you.

Active H2 Ultra is a fast-effervescing tablet.

MOLECULAR HYDROGEN BACKGROUND

More than 1,000 scientific studies indicate molecular hydrogen offers therapeutic potential in 170 disease models, and every organ of the body, according to the Molecular Hydrogen Institute.

Hydrogen is an antioxidant. It is also an extremely small molecule that can penetrate even the tiniest cellular compartments. This helps explain how hydrogen works to offer free-radical defense throughout the entire body.

The medical and scientific literature is clear. Hydrogen’s modes of action:

H2 reduces oxidative stress as a selective antioxidant and by maintaining homeostatic levels of glutathione, superoxide dismutase, catalase, etc.

H2, like other gaseous signaling molecules (i.e. NO, CO, H2S), appears to have cell signal-modulating activity affording it with anti-inflammatory, anti-obesity, and anti-allergy benefits.

We include hydrogen supplements in HPDI’s system of Foundational Supplements. In fact, hydrogen formulas as just one of six foundational supplements. We consider hydrogen a “secondary” foundational supplement usually to be added to a supplement regimen after the four primary ones: multivitamins, antioxidant & vitamin C formulas, essential fatty acids, and superfoods high in dietary nucleic acids (i.e., Rejuvenate! superfoods).

THERAPEUTIC USES OF HYDROGEN

The scientific literature discusses the use of molecular hydrogen for many clinical applications, including:

• Metabolic Syndrome including diabetes, hyperlipidemia, arteriosclerosis, hypertension, and obesity

• Ischemia/reperfusion injuries, including cerebral and myocardial infarctions, organ transplants, post-cardiac arrest

• Neuroprotection, including applications for dementia, Parkinson’s disease, depression, and anesthesia

• Inflammation, including applications for polymicrobial sepsis, rheumatoid arthritis, wound healing, and bowel diseases

• Mitochondrial diseases

• Hemodialysis and ventilation

• Aging, including cognitive decline

• Exercise, including applications for fatigue, lactic acid, recovery, and oxidative stress related to heavy exercise

Side effects of cancer therapies, including radiotherapy and chemotherapy

• Many other benefits

(Source: Molecular Hydrogen Foundation)

HOW HYDROGEN WORKS

According to the Molecular Hydrogen Foundation, there are three ways molecular hydrogen exerts positive health effects:

1.  Molecular hydrogen easily diffuses into subcellular compartments where it scavenges cytotoxic oxygen radicals, thereby protecting DNA, RNA, and proteins against oxidative stress.

2.  Molecular hydrogen triggers activation or upregulation of additional antioxidant enzymes (e.g., glutathione, superoxide dismutase, catalase, and others) and/or cytoprotective proteins of the body.

3.  Molecular hydrogen may be a novel signaling molecule that alters cell signaling, cell metabolism, and gene expression. This may explain its apparent anti-inflammatory, anti-allergic, and anti-apoptotic (or anti-cell death) effects.

Notably, two of these three mechanisms of action involve antioxidant activity. Hydrogen is one of the best antioxidants for all the reasons discussed, and we believe it acts synergistically with other antioxidants, including Vitamin C, glutathione, and Nrf2 activators (like those in HPDI’s Ultimate Protector).

MEGAHYDRATE MAKES MOLECULAR HYDROGEN BETTER

Why add Megahydrate to your hydrogen-infused water? Because Megahydrate provides hydride, the negative anion of hydrogen, or H-. Thus, a tiny scoop of Megahydrate provides vast quantities of electrons available to quench free radicals. Unlike molecular hydrogen, which dissipates quickly into the air, and therefore must be consumed immediately, hydride rich water (about -700 ORP!) may last for three weeks in an active state. That is a good reason to take Megahydrate by itself whether or not you already use it with molecular hydrogen in your hydrogen “fizzy” drink (see recipe above).

Megahydrate Active H2 Ultra

Megahydrate (powder or capsule) provides hydride (H-) for free radical defense.

The interesting thing about H- is that after it gives up its electron, it becomes simply “H” or atomic hydrogen. It then looks to pair up with another “H” to become H2, which is molecular hydrogen. In this way, Megahydrate not only gives you large quantities of stable H- and potent antioxidant capabilities, but also then creates molecular hydrogen in your body. This means it becomes a different kind of antioxidant, H2, which is therapeutic in itself.

By adding Megahydrate to your hydrogen-infused water (as described above), you create a unique “double whammy” drink in which you maximize the powers of hydrogen (H2 and H-) to create and maintain good health.

Note: Megahydrate powder is more cost effective than Megahydrate capsules, which must be opened into the fizzy drink. However, Megahydrate capsules are convenient for traveling and are easy to take by themselves. I keep both available, so I can use either one depending on my daily needs.

hydrogen supplements active h2 ultra

DRINKING HYDROGEN-INFUSED WATER

Drinking H2-rich water is an easy, effective method for obtaining hydrogen according to the Molecular Hydrogen Foundation. Drinking hydrogen-infused water is convenient as you can drink it at home or while traveling. Effective hydrogen products HPDI carries include Active H2 Ultra tabletsMegahydrate capsules, and Megahydrate powder.

As noted, I make 1–3 hydrogen drinks daily using Megahydrate and Active H2 Ultra. I drink them on an empty stomach. I enjoy a significant energy boost, which helps power me through my day. I gain other benefits, including improved athletic performance, noticeably faster recovery from exercise, and an overall greater sense of well-being.

The nice thing about hydrogen supplements is how flexibly you can use them. While I typically prefer to make hydrogen-infused “fizzy” drinks in water, I will often sip Megahydrate-infused water by itself during the day or even in the evening (as it is less energizing than molecular hydrogen).

Megahydrate does not immediately lose its potency in water, so it can be casually sipped. Also, if you’re traveling or on-the-go, you can simply swallow a Megahydrate capsule by itself. Finally, you can carry Active H2 Ultra tablets with you wherever you go, and add them to water whenever convenient for you.

http://www.integratedhealth.com/supplements/hydrogen-products.html

Megahydrate and Active H2 Ultra creates an ultra-healthy hydrogen fizzy drink.

TRY HYDROGEN!

Try hydrogen supplements for yourself. Then consider recommending them to client, patients, friends, and family. Most people welcome the results from hydrogen. This is especially true if they need exceptional free-radical defense — and who doesn’t? We can all stand to benefit from the proven health benefits hydrogen uniquely provides.

After you try hydrogen, you will want to continue taking it. Hydrogen-infused “fizzy” water can become your go-to drink. Remember, hydrogen works best when taken consistently and daily!

 

HYDROGEN RESOURCES

Hydrogen Articles

Hydrogen Supplements – Make Hydrogen Drinks

Hydrogen for Optimal Health

Wonders of Molecular Hydrogen

Molecular Hydrogen (H2) at the Forefront of Health Research

The Science Behind MegaHydrate by Hank Liers, PhD

Hydrogen Supplements

Active H2 Ultra tablets

Megahydrate capsules

Megahydrate powder

HPDI hydrogen products

Other Hydrogen Resources

Molecular Hydrogen Foundation

hydrogen supplements megahydrate active H2

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RESTORE GUT HEALTH FORMULA + VIDEO

Fred Liers PhD restore liquid mineral supplement gut healthHeard of RESTORE liquid mineral supplement? If not, you’re about to discover something important for gut health.

RESTORE™ is formulated to help restore gut health. It works by strengthening the integrity of tight junctions in your intestinal wall.

Maintaining tight junctions is important because they protect your body from substances entering the blood stream. Restore also supports the communications systems of the bacteria in your microbiome.

Tight junctions are natural barriers protecting the lining of your gut barrier, organs such as kidneys and heart, and the blood-brain barrier thereby keeping out unwanted substances. Even as we take in nutrients from the GI tract, the function of tight junctions is maintaining the integrity of the gut wall and other barriers that protect the body.

These days, our gut membrane has a tough job keeping out unwanted substances. Because tight junctions are weakened by many things, including highly processed foods, especially those containing gluten and gliadin, the herbicide glyphosate (the primary ingredient in RoundUp weedkiller), and other exposures like electromagnetic fields (EMF) from digital devices and Wi-Fi networks.

As a result of weakened tight junctions, undesirable substances from food proteins, harmful chemicals and other toxins can slip though into our bloodstream. This can lead to a powerful immune response that can weaken immunity and cause significant inflammation. Foreign substances in the bloodstream can also result in extreme food allergies and food sensitivities to various toxins entering the body.

We live in an age in which our microbiome health is under assault. Studies show our ancient ancestors had 20,000–30,000 different strains of beneficial bacteria in their GI tracts. Many people today have just 5,000 or less. Why is that?

There are many reasons for low microbiome diversity. These reasons include antiobiotic use (both from pharmaceuticals and foods), glyphosate (which essentially acts like an antibiotic), processed foods (especially those containing gluten and gliadin), and systemic degradation of the gut environment rendering it less hospitable for maintaining health populations of gut flora.

These impacts are significant because diversity in your microbiome not only supports gut health, but also appropriate brain health, immune system health, and overall vitality. Restore acts as a “microbiome fertilizer” helping establish and maintain healthy microbiota.

In fact, Restore contains important “redox” molecules produced millions of years ago by existing soil bacteria. These molecules are an important part of communications systems within the body between gut bacteria and with the body’s mitochondria. These communication systems play an important role in establishing proper homeostasis throughout the body.

REASONS TO USE RESTORE™

There are important reasons to try Restore—whether or not you experience significant gut health issues. These reasons include:

• Maintaining strong tight junctions for mega membrane health, and helping the body restore tight junction integrity

• Creating an environment in which beneficial bacteria can thrive

• Boosting microbiome diversity

• Healing the gut

• Mitigating the adverse effects substances like antibiotics, gluten/gliadin, glyphosate, and GMOs on microbiome health

• Supporting immune system function

• Protecting integrity of blood-brain barrier

Other benefits include support for respiratory wellness, enhancing mental clarity, and promoting proper homeostasis throughout the body.

For all these reasons and more, you should consider taking Restore. You can start by taking one teaspoon or less daily, and gradually increasing your dose to one tablespoon or more.Restore for gut health liquid supplement

I have taken Restore daily for more than two years, and benefit greatly from it. The most noticeable effects are a complete cessation of spring allergies (after two decades of worsening symptoms), greater clarity of thinking, and improved overall well being. I have seen other people get good results with a variety of conditions from dysbiosis to gluten/gliadin sensitivity.

MORE ABOUT RESTORE™

You can learn more about Restore on our website. Also, the Restore website offers in-depth information and videos. Here is how the Restore website and Dr. Zach Bush describe the formula:

Restore is a dietary supplement supplying first line defense against daily exposure to environmental and food-borne factors. It helps create an optimal environment or ecology in the gut membrane for beneficial or “good” bacteria to flourish. Beneficial gut flora protect your immune system and maintain health. Restore is a scientifically proven soil-derived mineral supplement designed to support protection of the intestinal walls.

Restore protects the entire gastrointestinal (GI) tract against agricultural herbicides, antibiotics, GMOs, gluten, and food-borne toxins. It helps create an environment in which 20,000–30,000 different strains of beneficial gut bacteria can thrive. This is a far different mode of action from probiotics, most of which contain just 3–30 strains of beneficial bacteria.

Restore helps create a strong immune system along with proper gut function. Microbiome balance and tight junction integrity are known to constitute a significant part of the immune system. They directly affect DNA transcription of cells to promote optimal health and prevent a leaky gut syndrome, thereby improving gut intelligence.

Seventy percent (70%) of our immune system is found in our gut. We need tens of thousands different strains of good gut bacteria to support a healthy immune system. Clinical experience, in addition to cell culture studies, support the theory that Restore’s proprietary formula creates the optimal environment in the gut to create a tight junction barrier and maintain our health and wellness.

Restore is a daily liquid supplement designed to support the protection of the entire gastrointestinal (GI) tract against agricultural herbicides, antibiotics, GMOs, gluten and food-borne toxins by helping to create an environment where between 20,000-30,000 different strains of good gut bacteria thrive. Most probiotics on the market contain fewer than 24 different strains of good gut bacteria.

TRY RESTORE™

Restore is ideal for individuals suffering from gut health issues. Yet, it is also excellent for supporting and maintaining gut health generally. That is the reason we at HPDI consider Restore important enough to designate as a foundational supplement, one of the top six supplements you need for good health.

Given the safety and effectiveness of Restore, there is broad applicability for its use. This is especially true because gut and microbiome health are under constant assault. These assaults range from multiple environmental and lifestyle factors—including poor diets high in processed foods, antibiotics in pharmaceuticals and animal foods—to massive glyphosate (herbicide) contamination of foods, soils, air, and water.

Let Restore be your first line of defense against assaults on your gut health, tight junctions, microbiome diversity, and immune function. As it says on the bottle, “Complete well-being begins in the gut.”

RESTORE RESOURCES

Gut Health – Effects of Glyphosate and Antibiotics
by Hank Liers, PhD and Fred Liers, PhD

Restore – 32 oz

Restore – 8 oz

HPDI Gut Health Formulas

HPDI Foundational Supplements

Restore blog (Restore4Life)