Heard of RESTORE liquid mineral supplement? If not, you’re about to discover something important for gut health.
RESTORE™ is formulated to help restore gut health. It works by strengthening the integrity of tight junctions in your intestinal wall.
Maintaining tight junctions is important because they protect your body from substances entering the blood stream. Restore also supports the communications systems of the bacteria in your microbiome.
Tight junctions are natural barriers protecting the lining of your gut barrier, organs such as kidneys and heart, and the blood-brain barrier thereby keeping out unwanted substances. Even as we take in nutrients from the GI tract, the function of tight junctions is maintaining the integrity of the gut wall and other barriers that protect the body.
These days, our gut membrane has a tough job keeping out unwanted substances. Because tight junctions are weakened by many things, including highly processed foods, especially those containing gluten and gliadin, the herbicide glyphosate (the primary ingredient in RoundUp weedkiller), and other exposures like electromagnetic fields (EMF) from digital devices and Wi-Fi networks.
As a result of weakened tight junctions, undesirable substances from food proteins, harmful chemicals and other toxins can slip though into our bloodstream. This can lead to a powerful immune response that can weaken immunity and cause significant inflammation. Foreign substances in the bloodstream can also result in extreme food allergies and food sensitivities to various toxins entering the body.
We live in an age in which our microbiome health is under assault. Studies show our ancient ancestors had 20,000–30,000 different strains of beneficial bacteria in their GI tracts. Many people today have just 5,000 or less. Why is that?
There are many reasons for low microbiome diversity. These reasons include antiobiotic use (both from pharmaceuticals and foods), glyphosate (which essentially acts like an antibiotic), processed foods (especially those containing gluten and gliadin), and systemic degradation of the gut environment rendering it less hospitable for maintaining health populations of gut flora.
These impacts are significant because diversity in your microbiome not only supports gut health, but also appropriate brain health, immune system health, and overall vitality. Restore acts as a “microbiome fertilizer” helping establish and maintain healthy microbiota.
In fact, Restore contains important “redox” molecules produced millions of years ago by existing soil bacteria. These molecules are an important part of communications systems within the body between gut bacteria and with the body’s mitochondria. These communication systems play an important role in establishing proper homeostasis throughout the body.
REASONS TO USE RESTORE™
There are important reasons to try Restore—whether or not you experience significant gut health issues. These reasons include:
• Maintaining strong tight junctions for mega membrane health, and helping the body restore tight junction integrity
• Creating an environment in which beneficial bacteria can thrive
• Boosting microbiome diversity
• Healing the gut
• Mitigating the adverse effects substances like antibiotics, gluten/gliadin, glyphosate, and GMOs on microbiome health
• Supporting immune system function
• Protecting integrity of blood-brain barrier
Other benefits include support for respiratory wellness, enhancing mental clarity, and promoting proper homeostasis throughout the body.
For all these reasons and more, you should consider taking Restore. You can start by taking one teaspoon or less daily, and gradually increasing your dose to one tablespoon or more.
I have taken Restore daily for more than two years, and benefit greatly from it. The most noticeable effects are a complete cessation of spring allergies (after two decades of worsening symptoms), greater clarity of thinking, and improved overall well being. I have seen other people get good results with a variety of conditions from dysbiosis to gluten/gliadin sensitivity.
MORE ABOUT RESTORE™
You can learn more about Restore on our website. Also, the Restore website offers in-depth information and videos. Here is how the Restore website and Dr. Zach Bush describe the formula:
Restore is a dietary supplement supplying first line defense against daily exposure to environmental and food-borne factors. It helps create an optimal environment or ecology in the gut membrane for beneficial or “good” bacteria to flourish. Beneficial gut flora protect your immune system and maintain health. Restore is a scientifically proven soil-derived mineral supplement designed to support protection of the intestinal walls.
Restore protects the entire gastrointestinal (GI) tract against agricultural herbicides, antibiotics, GMOs, gluten, and food-borne toxins. It helps create an environment in which 20,000–30,000 different strains of beneficial gut bacteria can thrive. This is a far different mode of action from probiotics, most of which contain just 3–30 strains of beneficial bacteria.
Restore helps create a strong immune system along with proper gut function. Microbiome balance and tight junction integrity are known to constitute a significant part of the immune system. They directly affect DNA transcription of cells to promote optimal health and prevent a leaky gut syndrome, thereby improving gut intelligence.
Seventy percent (70%) of our immune system is found in our gut. We need tens of thousands different strains of good gut bacteria to support a healthy immune system. Clinical experience, in addition to cell culture studies, support the theory that Restore’s proprietary formula creates the optimal environment in the gut to create a tight junction barrier and maintain our health and wellness.
Restore is a daily liquid supplement designed to support the protection of the entire gastrointestinal (GI) tract against agricultural herbicides, antibiotics, GMOs, gluten and food-borne toxins by helping to create an environment where between 20,000-30,000 different strains of good gut bacteria thrive. Most probiotics on the market contain fewer than 24 different strains of good gut bacteria.
Restore is ideal for individuals suffering from gut health issues. Yet, it is also excellent for supporting and maintaining gut health generally. That is the reason we at HPDI consider Restore important enough to designate as a foundational supplement, one of the top six supplements you need for good health.
Given the safety and effectiveness of Restore, there is broad applicability for its use. This is especially true because gut and microbiome health are under constant assault. These assaults range from multiple environmental and lifestyle factors—including poor diets high in processed foods, antibiotics in pharmaceuticals and animal foods—to massive glyphosate (herbicide) contamination of foods, soils, air, and water.
Let Restore be your first line of defense against assaults on your gut health, tight junctions, microbiome diversity, and immune function. As it says on the bottle, “Complete well-being begins in the gut.”
I love hydrogen supplements. So should you. Since starting my morning—and often afternoon—routine of making hydrogen drinks in the kitchen, I have come to appreciate the surge of energy lasting many hours, as well as a host of other benefits.
Most of all, I am amazed how easy hydrogen supplements are to use considering how much they do for you, and how well they complement the supplements I already take—seeming to make them all more effective.
I typically use one or two effervescing Active H2 Ultra tablets in 8–16 ounces of water. Then I like to open one Megahydrate capsule directly in the effervescing water. I wait about 90 seconds to let the tablets stop “fizzing” and then I drink immediately. Allowing the drink to sit for a few minutes is okay, but the sooner you drink it, the higher the concentration of hydrogen.
Note: I used Vital Reaction tablets in this video, but my preferred product is the new, improved Active H2 Ultra (tablets) which dissolves in less than one minute—faster than other hydrogen tablet formulas—thereby preserving more hydrogen in the water.
HYDROGEN SUPPLEMENTS ARE EFFECTIVE
Hydrogen supplements are among the newer, cutting-edge nutritional formulas available to support optimal health. More than 500 scientific articles now support the therapeutic potential hydrogen for essentially every organ system and in 150 human disease models, according to the non-profit Molecular Hydrogen Foundation. In fact, hydrogen is rapidly incorporated into medicine, sports medicine, peak performance, elite fitness, and more.
Hydrogen is an antioxidant. It is also an extremely small molecule that can penetrate even the tiniest cellular compartments. This helps explain how hydrogen works to offer free-radical defense throughout the entire body.
The medical and scientific literature is clear. Hydrogen’s modes of action:
H2 reduces oxidative stress as a selective antioxidant and by maintaining homeostatic levels of glutathione, superoxide dismutase, catalase, etc.
H2, like other gaseous signaling molecules (i.e. NO, CO, H2S), appears to have cell signal-modulating activity affording it with anti-inflammatory, anti-obesity, and anti-allergy benefits.
The scientific literature discusses the use of molecular hydrogen for many clinical applications, including:
• Metabolic Syndrome including diabetes, hyperlipidemia, arteriosclerosis, hypertension, and obesity
• Ischemia/reperfusion injuries, including cerebral and myocardial infarctions, organ transplants, post-cardiac arrest
• Neuroprotection, including applications for dementia, Parkinson’s disease, depression, and anesthesia
• Inflammation, including applications for polymicrobial sepsis, rheumatoid arthritis, wound healing, and bowel diseases
• Mitochondrial diseases
• Hemodialysis and ventilation
• Aging, including cognitive decline
• Exercise, including applications for fatigue, lactic acid, recovery, and oxidative stress related to heavy exercise
• Side effects of cancer therapies, including radiotherapy and chemotherapy
• Many other benefits
(Source: Molecular Hydrogen Foundation)
HOW HYDROGEN WORKS
According to the Molecular Hydrogen Foundation, there are three ways molecular hydrogen exerts positive health effects.
1. Molecular hydrogen easily diffuses into subcellular compartments where it scavenges cytotoxic oxygen radicals, thereby protecting DNA, RNA, and proteins against oxidative stress.
2. Molecular hydrogen triggers activation or upregulation of additional antioxidant enzymes (e.g., glutathione, superoxide dismutase, catalase, and others) and/or cytoprotective proteins of the body.
3. Molecular hydrogen may be a novel signaling molecule that alters cell signaling, cell metabolism, and gene expression. This may explain its apparent anti-inflammatory, anti-allergic, and anti-apoptotic (or anti-cell death) effects.
Active H2 Ultra hydrogen supplement (60 tablets).
HYDROGEN IS SAFE
Molecular hydrogen exhibits great safety, and it is regarded as safe for use in the body. It is shown no toxicity even in high concentrations.
Safety standards have long been established for high concentrations of hydrogen for inhalation largely because of the history of high-pressure H2 gas used in deep-water diving gas mixtures for preventing decompression sickness.
Notably, H2 gas combusts only at temperatures higher than 527 °C, and it explodes by chain reaction with oxygen (O2) only in the range of H2 concentration (4–75%, vol/vol).
Molecular hydrogen is used for medical applications safely by several ingestion methods including inhalation of 1–4% hydrogen gas, for example, which exhibits great effectiveness. All these factors mean that hydrogen is safe, easy-to-use, and effective for therapeutic purposes.
DRINKING HYDROGEN-INFUSED WATER
According to the Molecular Hydrogen Foundation, drinking H2-rich water is the easiest, and often the most effective, method for obtaining hydrogen.
Drinking hydrogen-infused water is easy to do, and convenient as you can drink it at home or while traveling. Effective hydrogen products HPDI carries include Active H2 tablets and Megahydrate capsules.
As noted, I make one or two hydrogen drinks daily, first in the morning and then often again in the afternoon. I drink them on an empty stomach. I enjoy a significant energy boost, which helps power me through my day. I gain other benefits, including improved athletic performance, noticeably faster recovery from exercise, and an overall greater sense of well-being.
I highly recommend you try hydrogen supplements for yourself, and then consider them for your clients or patients. Our experience is that most people are pleasantly surprised by the results they get from hydrogen supplements, especially if they have a need for exceptional free-radical defense, or stand to benefit from the proven effects hydrogen uniquely provides (see list above).
Once you try hydrogen, you will want to continue taking it because the benefits are so significant. Let the power of hydrogen starting working for you on a daily basis!
Dr. G. Patrick Flanagan’s Megahydrate (60 capsules).
As if Rejuvenate! PLUS weren’t already the delicious, nutritious superfood you know and love. Now, Dr. Hank Liers, HPDI’s formulator, has enhanced the formula for a truly remarkable taste and nutrition experience, you must try for yourself to believe!
The name Rejuvenate! Plus remains, but think of it as “version 2.0” because the nutritional upgrades and taste improvements are striking.
By the way, the “new” Rejuvenate! Plus is available now, so you can look forward to a truly remarkable user experience. We are confident you will be more than pleasantly surprised.
You will not believe your tastebuds when you try the new Rejuvenate! Plus. My humble opinion? Dr. Hank (my father and HPDI’s formulator) has knocked it out of the park in his revised formula.
Reports from sample testers have been overwhelmingly positive! Individuals who loved Rejuvenate! Plus unanimously love the new formula even more. That says a lot about this reformulation.
Rejuvenate! Plus 2.0 – healthy ingredients and taste at whole new level!
Other testers, who preferred our Rejuvenate! Berries & Herbs or Original Greens formulas either say they will now add Rejuvenate! Plus to their regimen, or will mix it in with their current favorite Rejuvenate! superfood.
Some individuals sampling the new formula who had never tried it before or previously did not often use Rejuvenate! Plus have decided to use it as their primary superfood—or take it daily.
We couldn’t be happier because these reports confirm the new Rejuvenate! Plus is a significant improvement over previous versions, and make our year-long effort to reformulate the product worth it. These early reports based on product samples show we have succeeded!
Some things haven’t changed: Rejuvenate! Plus remains the most popular and best-selling of all HPDI Rejuvenate superfoods. As always, it provide therapeutic levels (at least 340 mg) of dietary nucleic acids (RNA, DNA), greens (chlorella and spirulina) as in the lighter, sweeter greens (as compared to dark intense green-ness of Rejuvenate! Original greens) that both leads to slower, yet effective detoxification, and is powerfully energizing and cleansing. Rejuvenate! Plus also remains a foundational supplement that retains a complete built-in multivitamin sub-formula.
What then has changed? In short, we have changed a few ingredients, added or upgraded other ingredients, increased protein and nucleic acids (RNA) content, and created better tasting product overall. Here is a brief summary:
The “new” Rejuvenate! PLUS features (per serving):
1) 500 mg more spirulina (1,900 mg total), which actually increases the RNA content by about 15 mg
2) 2.3 grams more protein for a total of 13.9 grams
3) Almost no sugar (just 0.6 g total)
4) 2.3 g of powerful broccoli and alfalfa sprout extract powders
5) 200 mg of organic BiAloe® aloe vera powder with over 18% acemannan
6) 5-MTHF (500 mcg) — a better form of folate
6) An extremely smooth texture, and even more delicious taste—users rate as significantly better than prior versions—which says a lot because Rejuvenate! Plus already tasted great.
In short, these are the changes that make the new, improved Rejuvenate! Plus a significantly better product. Now I will delve a bit deeper into each of these changes, as well as specific changes to ingredients.
The new Rejuvenate! PLUS offers major improvements for optimal health.
REJUVENATE! PLUS IS A UNIQUE, HIGH-RNA SUPERFOOD
Rejuvenate! Plus is one three high-RNA superfoods Hank Liers of HPDI intentionally formulated to provide therapeutic levels of dietary nucleic acids. In this case, that means about 340 mg of nucleic acids per serving, and that has now been increased to at least 355 mg. The fact that Rejuvenate! Plus provides such high levels of dietary nucleic acids makes it—and the entire line of Rejuvenate! superfoods—unique!
A short history lesson: Benjamin S. Frank, MD, PhD discovered the benefits of dietary nucleic acids in the 1960s and 1970s. He performed various studies on humans and animals using various intakes of dietary RNA. He concluded that nucleic acids are essential nutrients like vitamins and minerals. Nucleic acids provide a host of unique health benefits that make getting RNA in your diet important.
After reading of Dr. Benjamin S. Frank’s works (including Dietary Nucleic Acid Nutrition and Therapy and The No-Aging Diet), my father Hank Liers and I decided to formulate a line of superfoods based on the idea of providing high levels of dietary nucleic acids for optimal health. That was 10 years ago.
Rejuvenate! Original Greens launched in 2007. Rejuvenate! Plus came two years later in 2009. Then Rejuvenate! Berries & Herbs in 2010. To this day, no other company has created dedicated high-RNA superfoods like HPDI’s Rejuvenate line.
DIETARY NUCLEIC ACIDS IN REJUVENATE! PLUS
What makes Rejuvenate! PLUS—and in fact the entire Rejuvenate! line of superfoods—unique? A single serving provides therapeutic levels (340+ mg) of dietary nucleic acids (RNA, DNA, nucleotides, and nucleosides). Here are a few of the benefits and effects of nucleic acids in the body:
HIGHER ENERGY (ATP) PRODUCTION
GREATER MUSCLE MASS / STRENGTH / ENDURANCE
SMOOTHER SKIN / MORE YOUTHFUL APPEARANCE
EASIER BREATHING / “ANTI-ANOXIA” EFFECT
ELEVATES TISSUE OXYGENATION
BENEFICIAL CARDIOVASCULAR EFFECTS
LOWER CHOLESTEROL LEVELS
OVERALL PHYSICAL REJUVENATION
TEMPERATURE TOLERANCE (COLD/HEAT)
IMPROVES LONGEVITY / QUALITY OF LIFE
FAR GREATER SUBJECTIVE WELL-BEING
Source: Nucleic Acid Nutrition and Therapy
Nucleic acids perform so many important functions in the body that getting sufficient amounts in the your diet is probably essential, just as Dr. Benjamin S. Frank asserts. That can be difficult since historically they were obtained from fish, organ meats—foods that people today may not consume in sufficiently high amounts for a variety of reasons. These reasons may include issues of taste, emphasis on vegetarian foods, concern about heavy metals or radiation, or lack of availability.
Rejuvenate! Plus in many ways helps take the guesswork from obtaining “essential” dietary nucleic acids by providing a vegetarian, gluten free, and non-GMO source of dietary RNA—along with protein, vitamins, minerals, cofactors, and other important nutrients—in a tasty, easy-to-take powder that stays fresh for months, travels well, and can be taken in a variety of ways from smoothies to plain water!
TRY REJUVENATE! PLUS
You (or your clients) have everything to gain by trying Rejuvenate! PLUS. As you can see, the updated superfood is carefully formulated to help create and maintain optimal health.
When used together with other HPDI foundational supplements and the HPDI supplement system, Rejuvenate! Plus is another “brick in your wall” of good health and can make a huge difference in terms of how you feel, perform, and function in life.
Try the new, improved Rejuvenate! PLUS “2.0” superfood. See for yourself not only how good it tastes, but how good it can help make you feel. That’s goodness all around!
Multivitamins are the most important of the basic or foundational supplements providing nutrients essential for health and wellness. Because if there is a single nutritional supplement everyone should take, a multivitamin is it.
But it can’t be just any multivitamin. The best multivitamins are complete, high-potency, high-quality, high-purity, provide a complete range of essential vitamins and minerals, and contain advanced forms—more about advanced forms later.
The purpose of taking a high-potency multivitamin not only is to provide the body with amounts and forms of nutrients meeting minimum requirements for avoiding deficiency conditions, but also sufficient levels of nutrients that can support optimal health. Because vitamins levels for optimal health are NOT the same as levels required to avoid deficiency conditions.
MORE THAN DAILY ALLOWANCES
While 40% of Americans say they take a multivitamin daily, how many actually obtain all the nutrients they need for optimal health from taking it? Practically no one. Why?
Because basic “recommended daily amounts” (100% of daily allowance) typically found in multivitamins are based on models for disease prevention. That is, these are minimum levels indicated to avoid conditions like Pellagra (caused by vitamin B3 deficiency), Beriberi (caused by vitamin B1 deficiency), or Rickets (caused by vitamin D deficiency), for example. Nutrient fortification of foods by law has mostly eradicated those conditions. But, as noted, minimum recommended amounts are not the amounts required for optimal health.
The best multivitamin supplements therefore do not provide just 100% of a recommended daily amount of a certain nutrient, but far higher amounts. That is for truly optimal health, high-potency is a must in multivitamins. One of the main reasons for this is “biochemical individuality.” While most people fall within a certain range in terms of their needs for a specific nutrient, the overall range (or bell curve) may be quite large. Your needs may be greater.
Another, related reason is genetics. If you are heterozygous for a gene that requires a specific nutrient, then you may already be at a disadvantage for assimilating or processing it. If you are homozygous, then not having sufficient amounts of a nutrient can have much larger, adverse consequences.
For any given nutrient, then, your needs may be higher or significantly higher than other people’s needs. The best way to guarantee your needs are met is to ensure you consume larger amounts. That is, a high-potency multivitamin providing levels of nutrients well above the minimum amounts established to avoid deficiency.
MULTIVITAMINS ARE SAFE, LOW COST,
High-potency multivitamins work well because vitamins—at least at the levels we are talking about here—are non-toxic, safe, and well-tolerated. Add to the safety of vitamins their relatively low cost (especially compared to pharmaceuticals) that solidifies the case for high-potency multivitamins as a virtual “no-brainer” for supporting good health.
That is the basic rationale for why you need a high-quality, high-potency multivitamin. There are many other reasons. Such reasons include the fact that diet alone is usually not enough to provide the levels of basic nutrients you need.
DIET ALONE IS USUALLY INSUFFICIENT FOR OPTIMAL LEVELS OF NUTRIENTS
Diet alone could perhaps be sufficient if foods were nutrient-dense and you consumed enough of them. But foods today are typically not nutrient-dense given how modern agriculture has stripped the soils of essential nutrients. Herbicides and pesticides then poison foods. And the widely used glyphosate herbicide (RoundUp) actually depletes nutrients in foods by blocking their uptake in plants leading to further depletion in crop foods. Food processing then strips out additional nutrients. Get the picture?
On top of all this, your requirements for nutrients are increased by factors such as pollution and chemical exposures (and greater stress on detoxification organs), emotional stress, immune stresses (like fighting off colds or flu), and even free-radical stress caused by electromagnetic fields (EMFs) such as mobile phone and Wi-Fi exposures. In many cases, various stresses and environmental exposures put a greater burden on your antioxidant defense systems by subjecting you to free-radical attack. This is just the beginning.
Assuming your diet were “perfect” (which most likely it is not), your needs for various nutrients will vary depending on your levels of exposure to stresses (emotional, chemical, electromagnetic, etc.). This means that as your needs for extra nutrients rise to combat these stresses, the simplest and best way to meet those needs is through consuming additional, supplemental amounts of nutrients—to successfully meet those needs. Otherwise, having only minimal amounts (i.e., daily values created to avoid deficiency diseases) means your need for higher amounts will not be met.
IF YOU DO NOTHING ELSE, TAKE A HIGH-QUALITY MULTIVITAMIN
A multivitamin can meet those additional needs, or at least start meeting them. In fact, a multivitamin is the best “first line of defense.” In the HPDI system, a multivitamin is just one of six foundational supplements—but it “first among equals” and therefore the very first supplement we recommend. This means that if you do nothing else, then take a multivitamin.
Need another good reason to make a multivitamin? Again, genetics. HPDI has teamed up with Bodysync, the developer of Nutrisync genetic tests (available to HPDI resellers on the reseller website and to retail customers by phone) that offers testing for health-related genetic variations in your DNA.
Among the first things we realized after analyzing Nutrsync genetic test results is that many genetic variants that may cause problems with uptake of certain nutrients—or that require additional amounts of nutrients—can be partly or wholly mitigated by taking a high-potency multivitamin. This is not true in every case, but surprisingly the nutrients provided in a quality multivitamin can be a strong defense in this regard.
Another thing we noticed is that the results of almost everyone taking the Nutrisync test exhibit certain genetic weaknesses that would benefit from a multivitamin. Another “no brainer” observation that may not have been so obvious beforehand, yet which corresponds with what we have been recommending to clients for decades: Take a multivitamin!
People may not realize that optimal health is within reach. Taking a high-potency multivitamin daily is a major first step toward achieving it.
BENEFITS OF A HIGH-QUALITY, HIGH-POTENCY MULTIVITAMIN
Considering all the factors involved in optimal nutrition—and how important nutrition is to health—it is remarkable to think that your health can be well maintained or dramatically improved simply by taking a high-potency multivitamin. Yet, that is a fact. And
• Ensures complete nutrition by providing a wide-range of nutrients to supplement those obtainable by diet
• Provides optimal levels of nutrients in a balanced way
• Guards against deficiencies of particular nutrients
• Protects against nutrient depletion caused by increased needs for nutrients (e.g., various stresses or periods of inadequate intake).
• Helps you fulfill genetic potential by supplying nutrients required for optimal genetic expression and for overcoming adverse genetic factors
• Safe, low cost, and effective means to support good health
BENEFITS OF HPDI MULTIVITAMINS
HPDI formulates and sells some of the highest-quality, high-potency multivitamins available. Many of our customers are health professionals who supply their clients with our multivitamins—because health professionals demand supplements proven to be effective. And they know the difference!
• HPDI multivitamins provide a complete range of nutrients, including vitamins, minerals, cofactors, and phytonutrients
• Therapeutic levels of nutrients in amounts necessary for health—typically greater than daily values
• Nutrients balanced so as not to provide too little or too much of any given nutrient
• High-purity with minimal excipients, and avoidance of harmful excipients
• Advanced forms (including coenzyme vitamins) for optimal uptake, transport, and utilization
• Inclusion of coenzyme form B vitamins
• Inclusion of potent antioxidants and Nrf2 activators
• Formulated by Hank Liers, PhD, designer of supplements for 30 years
• Vegetarian capsules
Health Products Distributors, Inc. (HPDI) currently offers five multivitamins, including Mighty Multi-Vite!, Multi Two (tabs and caps), Mini Multi, and Chewable Kids Mighty-Multi. Each multivitamin is formulated for a specific purpose:
• Multi Two and Mighty Multi-Vite! are flagship multivitamins with advanced forms. Multi Two offers higher levels of B vitamins, whereas Mighty Multi-Vite! provides relatively more antioxidants and phytonutrients.
• Mini Multi is formulated for chemically and environmentally sensitive individuals or those who seek ultra-high purity. Mini Multi contains no excipients (i.e., additives or fillers), and provides 100% coenzyme vitamins.
• Chewable Kids Mighty-Multi! tastes great and includes xylitol to prevent cavities. Kids love this chewable formula, but it is also scalable for adults. This formula is most similar to Mighty Multi-Vite! in terms its nutrient content.
HPDI multivitamins: Multi Two (caps and tabs), Mighty Multi-Vite!, Mini Multi, and Chewable Kids Mighty-Multi.
HPDI MULTIVITAMINS IN DEPTH
1. MIGHTY MULTI-VITE!
HANK & BRIAN’S™ MIGHTY MULTI-VITE! (or as we often call it, the “Mighty Multi”) is perhaps the premier HPDI multivitamin, and definitely among the flagship multivitamins we offer. I personally take this one most of the time. It is in the “Hank & Brian’s” line, which generally are among our best products.
Mighty Multi incorporates the latest nutritional research in a complete formula that combines the highest-quality, most assimilable forms of vitamins and minerals along with advanced herbal nutrition.
Mighty Multi-Vite! is an advanced, cutting-edge multivitamin that is a leader within HPDI’s line of foundational supplements. This formula exhibits superior performance with respect to supporting optimal health, and is among the world’s most sophisticated multivitamins. Mighty Multi-Vite! works synergistically with other foundational supplements to help sustain maximum health, vitality, and promote longevity.
Now with these 7 absolutely essential improvements:
Now in an ultra-pure vegetarian capsule
Vitamin B12 is now in the methylcobalamin coenzyme form
Turmeric is now in an extract form with 95% curcuminoids – a powerful Nrf2 activator
Now uses broccoli sprouts powder containing sulforaphane – another powerful Nrf2 activator
Contains both Vitamin K1 and Vitamin K2 (as MK-7)
Contains the best coenzyme form of folate – L-5-MTHF
Contains no magnesium stearate
Mighty Multi-Vite! is an HPDI flagship multivitamin offering special nutrients for antioxidant protection.
COMPLETE, BALANCED ESSENTIAL NUTRITION – Provides a full spectrum of nutrients exceptionally well balanced for creating and maintaining optimal health. Mighty Multi-Vite! offers all the most important vitamins along with minerals, cofactors, antioxidants, and herbs.
RAPID, EASY ASSIMILATION – Incorporates the most bioavailable vitamin and mineral carriers most easily recognized and rapidly assimilated by your body. In addition, the formula uses multiple forms of mineral carriers to ensure assimilation. In addition, the capsule form speeds uptake because it does not require time for the body to break it down (unlike tablets).
ENERGIZING – Includes coenzyme form vitamins and Krebs Cycle bionutrients that work with your body to create super high energy levels. Provides significant levels of B vitamins (especially coenzyme B vitamins) known for boosting energy, supporting the body during times of stress, nerve function, heart function, and for working together with dietary RNA (found in Rejuvenate!™ superfoods) to produce significant therapeutic effects.
FOUNDATIONAL SUPPLEMENT – For creating health and establishing a complete supplement program. Providing excellent foundational nutrition, Mighty Multi-Vite! is designed to work synergistically with other foundational formulas for maximum health benefits.
In addition to the newest improvements, Mighty Multi-Vite! features:
A full spectrum of B-complex vitamins, most in coenzyme forms, as well as more conventional forms. Includes Vitamin B1 as thiamin HCl and thiamin diphosphate, Vitamin B2 as riboflavin and riboflavin-5′-phosphate, Vitamin B3 as niacinamide and niacin, Vitamin B5 as pantothenic acid, Vitamin B6 as pyridoxine HCl and pyridoxal-5′-phosphate, folate as L-5-methyltetrahydrofolate (L-5-MTHF), Vitamin B12 as methylcobalamin, and biotin.
All of the most absorbable and usable forms of the fat-soluble vitamin group, including Vitamin A (as beta-carotene), Vitamin E (as d-alpha tocopherol succinate), Vitamin D-3 (as cholecalciferol), Vitamin K (as phytonadione and MK-7).
A complete and balanced supply of the most abundant carotenoids found in the body, including beta- and alpha-carotene, as well as lycopene and lutein.
A variety of the best-known herbal preparations, including quercetin, grape extract, turmeric (95% curcuminoids), broccoli sprouts powder, octacosanol from policosanol, and stevia.
All of the known essential minerals in forms readily absorbed and recognized by the body including calcium, magnesium, potassium, zinc, manganese, boron, copper, chromium, molybdenum, vanadium, and selenium.
Mineral carriers such as ascorbates, Krebs cycle bionutrients and amino acids providing the body with important metabolic substrates and vitamins, including citrate, succinate, alpha-ketoglutarate, fumarate, malate, glycinate, aspartate, sebacate, and Vitamin C.
Includes the important sulfur-containing amino acid N-Acetyl-L-Cysteine to support the body’s antioxidant and detoxification systems and betaine HCl to support digestive processes.
Includes choline and inositol which play a crucial role in all of the cell membranes of the body, in brain function, and in liver function.
Exclusion of the prooxidant minerals of iron and iodine which can lead to excessive free-radical production and PABA that sometimes adversely affects brain function in some individuals. Note: we sell iodine as separate formulas.
Capsule form that ensures the maximum absorption of ingredients.
Four-per-day full dosage that allows for partial dosing for children, seniors, and pets.
Vegetarian formula – including capsule.
Capsule contents designed to smell and taste good to adults and children when emptied into smoothies, drinks, and foods. This allows greater flexibility of use.
Exclusion of ingredients such as wheat, gluten, dairy, corn, soy, and egg having well-known antigenic properties and that may be associated with allergy or delayed hypersensitivity reactions.
A minimum of excipients, fillers, lubricants, etc. having deleterious effects in some individuals. No GMOs.
As I mentioned previously, the Mighty Multi is uniquely advanced it that it provides special antioxidant ingredients like turmeric, grape extract, and broccoli sprouts powder.
2 & 3. MULTI TWO (CAPS & TABS)
MULTI TWO is another HPDI flagship multivitamin. We recommend it especially for individuals who prefer more B vitamins built into their multivitamin. Yet, it offers somewhat fewer antioxidant nutrients.
MULTI TWO is a pure, complete, biochemically formulated multivitamin supplement with minerals and cofactors. It dissolves readily and is highly bioavailable. All ingredients are sourced for purity and carefully selected to avoid common food allergens. MULTI TWO is available in tablet and vegetarian capsule forms.
MULTI TWO is among HPDI’s most popular multivitamins, providing top-notch quality, high-purity, advanced design and formulation, and exceptional value for the price.
The formula comes in tablet or capsule forms. The tablet is suitable for vegetarians, only containing plant fiber to bind components, further eliminating chemical contaminants. The capsule form now is also vegetarian. The capsules have a four-per-day full dosage allowing for partial dosing for children, seniors, and pets. Note: the capsule’s powder contents taste quite good to most people, so it can be added to sippy cups, blender drinks, smoothies, pet foods, etc.
MULTI TWO is one of HPDI’s foundational multivitamin supplements in our health recovery and maintenance programs. A foundational program of supplements includes a multivitamin, essential fatty acids, a Vitamin C formula, and a Rejuvenate!™ superfood.
Multi Two Caps are among HPDI’s premier therapeutic-grade multivitamin formulas providing a complete range of nutrients.
MULTI TWO OFFERS UNIQUE BENEFITS
COMPLETE, BALANCED FOUNDATIONAL NUTRITION. Full-Spectrum of Nutrients Exceptionally Balanced for Supporting Your Health. Foundational Formula Ideal for Providing Essential Foundational Nutrition. A high-quality multivitamin is the foundation (i.e., core) for a complete nutritional supplement program.
RAPID AND EFFECTIVE ASSIMILATION. Incorporates Bioavailable Vitamin and Mineral Carriers Your Body Recognizes and Can Assimilate Immediately. Plus, Multiple Carriers Ensure Assimilation. Tablet or Capsule Forms Rapidly Assimilated.
POWERFULLY ENERGIZING. Includes Coenzyme Form Vitamins and Krebs Cycle Bionutrients that work with your body to create high energy levels. Full-Spectrum Essential Nutrients Needed For Building, Supporting, and Maintaining Excellent Health.
HIGH PURITY. One of the Purest Available Supplements. Carefully Designed To Exclude Common Allergens, and Exclude or Minimize Excipients, Additives, and Fillers.
TABLET AND VEGETARIAN CAPSULE FORMS. We Offer Both Forms Giving You More Choice. Take Your Pick.
FOUNDATIONAL SUPPLEMENT. Providing solid foundational nutrition, MULTI TWO functions most effectively when used in conjunction with other foundational formulas, especially Vitamin C formulas (including ULTIMATE PROTECTOR™ and PRO-C™), Essential Fatty Acid formulas (including Omega Plus and Essential Fats Plus E), and REJUVENATE!™ superfoods. These foundational supplements together form the foundation of a complete nutritional supplement program. From here, you can add additional supplements (enhancements and specific condition formulas) addressing your individual needs, i.e., by pinpointing where your body requires additional nutritional support.
MULTI TWO FEATURES
A full-spectrum of B-complex vitamins, most in coenzyme forms, as well as more conventional forms. Includes Vitamin B1 as thiamin HCl and thiamin diphosphate, Vitamin B2 as riboflavin and riboflavin 5’-phosphate, Vitamin B3 as niacinamide and niacin, and Vitamin B6 as pyridoxine HCl and pyridoxal 5’-phosphate, folate from calcium folinate and 5-MTHF, Vitamin B12 as methylcobalamin and hydroxocobalamin, and biotin.
All of the most absorbable and usable forms of the fat-soluble vitamin group, including Vitamin A (as natural beta-carotene), Vitamin E (as d-alpha tocopherol succinate and mixed tocopherols), Vitamin D3 (as cholecalciferol), and two forms of Vitamin K (K1 as phylloquinone and K2 as menaquinone-7).
Effective herbal preparations, including quercetin, grape extract, octacosanol.
All of the known essential minerals in forms readily absorbed and recognized by the body including calcium, magnesium, potassium, zinc, manganese, boron, copper, chromium, molybdenum, vanadium, and selenium.
Mineral carriers such as ascorbates, Krebs cycle bionutrients, and amino acids providing the body with important metabolic substrates and vitamins, including citrate, succinate, alpha-ketoglutarate, fumarate, malate, glycinate, aspartate, sebacate, and Vitamin C.
Includes betaine HCl to support digestive processes.
Choline and inositol which play a crucial role in all of the cell membranes of the body, in brain function, and in liver function.
Exclusion of the prooxidant minerals of iron and iodine which can lead to excessive free-radical production and PABA that sometimes adversely affects brain function in some individuals.
Four-per-day full dosage of capsule form allows for partial dosing for children, seniors, and pets.
Tablet and capsule forms are vegetarian (except for pharmaceutical glaze on tablets).
Exclusion of ingredients such as wheat, dairy, corn, soy, and egg having well-known antigenic properties and that may be associated with allergy or delayed hypersensitivity reactions. Contains no GMOs.
A minimum of excipients, fillers, lubricants, etc. that exert deleterious effects in some individuals.
Multi Two is a great multivitamin and in many ways similar to the Mighty Multi-Vite!. However, Multi Two provides more B vitamins and in the case of certain B vitamins, it provides twice as much as Mighty Multi-Vite!. For anyone who requires plenty of B vitamins and who doesn’t necessarily want to take a separate, standalone B vitamin formula, Multi Two is an ideal multivitamin.
We call our Mini Multi the “World’s Purest Multivitamin.” This is because it was originally formulated for chemically and/or environmentally sensitive persons. The capsule is smaller than our other multivitamins which easily allows for partial dosing. It also is our only all coenzyme form multivitamin.
MINI MULTI is an ultrapure, biochemically formulated, complete multivitamin supplement that includes essential and trace minerals, and cofactors. MINI MULTI is highly bioavailable and contained in a preservative-free veggie capsule (helping eliminate chemical contaminants). The capsule contains no fillers, flow agents, or any other excipients. Each component is the highest purity.
MINI MULTI is ideal for chemically and environmentally sensitive individuals who require ultra-high purity supplements. The formula is designed by Dr. Hank Liers, who developed it as a ultra-pure formula for sensitive individuals. Yet, anyone can take MINI MULTI to benefit from its ultra-high purity and avoidance of additives, fillers, or other excipients.
Many individuals who take MINI MULTI are not chemically sensitive, but suffer from allergies, sensitive digestive tracts, wish to avoid gelatin capsules, or simply do not enjoy swallowing large capsules (or tablets).
Meet Mini Multi, the world’s purest multivitamin formulated originally for chemically and environmentally sensitive persons.
ADVANCED DESIGN INCLUDES NEARLY 100% COENZYME FORM B VITAMINS
MINI MULTI’s biochemical formulation incorporates the latest research on nutrient transport and interaction to enhance efficient metabolism and includes coenzyme forms of vitamins. The vitamins and minerals in MINI MULTI activate the body’s metabolic machinery, and synergistic cofactors aid absorption, assimilation, utilization, and metabolism of nutrients.
MINI MULTI is among the first multivitamins to provide almost all coenzyme form B vitamins (i.e., all except vitamin B3, which we include as niacinamide). Coenzyme form vitamins are the natural forms best recognized and utilized in the body. For example, MINI MULTI provides folate in the form of folinic acid (a natural form of folate) from calcium folinate and L-5-MTHF (another natural form of folate), rather than the typical and commonly used folic acid, a synthetic form requiring enzymatic processing in the body for utilization. That is, coenzyme vitamins are easier to assimilate (especially for older individuals or those with health conditions that reduce enzyme activity in vivo) and they are immediately recognized and used in the body.
FEATURES AND BENEFITS OF THE HIGHEST PURITY FORMULA AVAILABLE TODAY
The world’s purest multivitamin supplement, proven for more than a decade
Ideal for chemically, environmentally or allergen sensitive individuals, or anyone desiring an ultra-high purity in a nutritional supplement
Highly effective, complete formula includes vitamins, minerals, and cofactors (including powerful antioxidants)
Includes nearly 100% coenzyme form B vitamins for rapid assimilation (all except B3 which is included as niacinamide and B5 which is included as pantothenic acid)
Convenient four-per-day dosage allows easy for partial dosing
Suitable for vegans and vegetarians (veggie capsule)
Suitable for children (i.e., capsule may be opened and emptied into drinks or food)
No additives, fillers, flow agents, or any other excipients!
Nothing artificial or synthetic!
In fact, MINI MULTI does not contain wheat, rye, oats, corn, barley, gluten, egg, dairy, citrus, yeast, sugar, GMOs, wax, sulfates, phosphates (other than coenzymes), preservatives, fillers, binders, coatings, colorings, or artificial flavorings
MINI MULTI exhibits superior design, technical sophistication, ease of use, and high perfomance. We suggest you try it whether you are sensitive to fillers or flow agents, suffer from allergies due to common additives, wish to avoid artificial ingredients, or simply want the purest multivitamin available.
In this day and age when many individuals suffer from allergies to ingredient sensitivities, Mini Multi represents a choice for the ultimate in high-purity. No excipients means a cleaner supplement option for anyone who may need it.
5. CHEWABLE KIDS MIGHTY-MULTI
HPDI’s KIDS MIGHTY-MULTI! is truly one-of-a-kind. It is most similar to the Mighty Multi-Vite! in terms of the nutrients it provides, including antioxidants. However, it is our only chewable and it tastes great.
KIDS MIGHTY-MULTI! is an advanced chewable multivitamin for children incorporating the latest nutritional research in a tasty, complete formula combining the highest-quality and most usable forms of vitamins, minerals, herbs, and cofactors.
Our children’s multivitamin formula provides optimal levels of basic essential nutrients and thereby is an ideal foundation upon which to build a complete nutritional supplement program. A high-quality multivitamin is the starting-point for building a program uniquely designed to suit to your child’s individual requirements.
We offer KIDS MIGHTY-MULTI! as a “top-of-the-line” children’s formula that tastes great and produces exceptional results. This unique formula very effectively provides children with a solid foundation of nutrients for establishing, building, supporting, and maintaining excellent health during this critical period of their lives.
COMPLETE FORMULA – the most complete children’s formulas available! It provides a full-spectrum of essential nutrients needed for creating, supporting, and maintaining excellent health for your child. It includes natural coenzyme form vitamins and Krebs cycle bionutrients that work with young bodies to provide energy for metabolic processes, healing, and optimal heatlh.
AMAZING TASTE, NATURALLY– the most delicious kids multivitamin you’ll ever taste! Flavored with only healthy, natural sweeteners and functional taste enhancers, including mannitol, xylitol, fructooligosaccharides (FOS) (from chicory root), natural fruit flavor, and stevia leaf extract. Most of these taste enhancers actually exhibit other positive benefits in the body (i.e., prebiotic effects, cavity prevention, and antioxidant action). Kids (and adults) love the taste!
BALANCED ESSENTIAL NUTRIENTS – exceptionally balanced nutrients for supporting your child’s health. This is a foundational formula ideal for providing basic nutrients for health. Indeed, a high-quality multivitamin is a basic foundational formula (along with vitamin C and essential fatty acid formulas) in a nutritional supplement program. Our kids’ formula puts your child on the nutritional track he or she deserves right from the start!
“ULTRA PURE” – excludes common food source allergens (like wheat, corn, soy, or dairy). Also excludes unnecessary excipients, fillers, binders, and additives. Unlike many children’s vitamins, ours contains NO artificial colorings or flavorings, artificial sweeteners (like aspartame, saccharin, or sucralose) or hydrogenated vegetable oils…substances that can have deleterious effects on health (yet are frequently include. Plus, NO sugar and NO GMOs!
RAPID ASSIMILATION – incorporates bioavailable vitamin and mineral carriers the body recognizes and can assimilate immediately. Plus, multiple carriers ensure assimilation. Chewable form speeds uptake in the body.
FOUNDATIONAL FORMULA – forms the foundation of a complete supplement program for your child. Formulated to work with other foundational formulas, including Vitamin C formulas (like PRO-C™) and essential fatty acid formulas (like Essential Fats plus E) that together form the basis of a complete nutritional supplement program. You can also add specific supplements addressing your individual needs of your child, i.e., by pinpointing where he or she may require additional nutritional support. Such specific supplements might include Allergy Support Plus, Joint Health Formula, or Ultimate Protector™ (super antioxidant & Nrf2 activator formula).
Kids Mighty-Multi is the perfect multivitamin for kids offering appropriate levels of a wide range of important vitamins, minerals, cofactors, and antioxidants.
• A full-spectrum of B-complex vitamins primarily in coenzyme forms, including Vitamin B1 (as thiamin diphosphate), Vitamin B2 (as riboflavin-5’-phosphate), Vitamin B3 (as niacinamide and niacin), Pantothenic acid), Vitamin B6 (as pyridoxal 5’-phosphate), folate (as 5-MTHF), Vitamin B12 (as methylcobalamin), and Biotin.
• All of the most absorbable and usable forms of the fat-soluble vitamin group, including Vitamin A (as natural beta-carotene), Vitamin E (as d-alpha tocopherol succinate and mixed tocopherols), Vitamin D3 (as cholecalciferol), and Vitamin K (as phylloquinone (K1) and MK-7 (K2)).
• A complete and balanced supply of the most abundant carotenoids found in the body, including Beta-Carotene, Lycopene, and Lutein.
• A variety of the best-known herbal ingredients, including Quercetin, Grape Extract, Turmeric extract, Broccoli Sprouts Powder, and Octacosanol (from policosanol).
• Readily absorbed forms of all essential minerals, including Calcium, Magnesium, Potassium, Zinc, Iron, Manganese, Boron, Copper, Chromium, Molybdenum, Vanadium, and Selenium.
• Easily assimilated mineral carriers, including ascorbates (Vitamin C), Krebs cycle bionutrients (citrate, succinate, alpha-ketoglutarate, fumarate, malate), and amino acids (e.g., glycine, taurine, and aspartic acid) that provide the body with important metabolic substrates and vitamins.
• Sulfur-containing amino acids supporting the body’s detoxification systems.
• Natural taste-enhancing complex of xylitol, mannitol, FOS, and stevia leaf extract. Tasty fruit flavor kids love!
• Therapeutic levels of xylitol helping to prevent cavities.
• Significant levels of choline and inositol that play a crucial role in all cell membranes, and in brain and liver function.
• Betaine HCl to support digestive processes.
• Exclusion of the pro-oxidant mineral iodine that may lead to excessive free radical production and PABA that can adversely affect brain function. We actually prefer the safer and more therapeutic Nascent Iodine over the forms normally found in vitamin formulas.
• Exclusion of substances that have well-known antigenic properties and that may be associated with allergy or delayed hypersensitivity reactions, including wheat, corn, soy, egg, and dairy.
• Minimum of excipients, fillers, or additives (that may have deleterious effects in some individuals).
• Small tablet size allows for weight-dependent dosing (two tablets per 20 lbs body weight)
MORE ABOUT KIDS MIGHTY-MULTI!
A Better, Safer Multivitamin for Kids
The vast majority of children’s vitamins today are decidedly not advanced formulations. They typically provide only minimum amounts (i.e., no more than government mandated daily values) of vitamins, minerals, and other nutrients. In addition, most kids’ vitamin on the market remain filled with sugars and artificial ingredients, including aspartame (a known toxin), artificial colorings, preservatives, hydrogenated oils, and other toxic substances.
Consider what our Kids Mighty-Multi! does NOT contain:
Aspartame. There is controversy surrounding this artificial sweetener, which is associated with a variety of neurological problems. In fact, there is widespread consensus that children under six should not use aspartame. We believe no one should consume aspartame at any age!
Refined sugars (usually listed as, sucrose, etc.). There is no place for sugar in multivitamins. Sugar in supplements is also dangerous because when coupled with ascorbic acid, it can damage teeth! Chewable kids vitamins containing sugar expose your child’s teeth to double jeopardy.
Artificial dyes (FD&C Yellow, Blue, and/or Red). Artificial colors are associated with a wide range of health and behavioral problems. These include carcinogenicity, and contributing to learning problems like ADHD. In addition, FD&C Yellow dye #5 (tartrazine) is one of the main food triggers of asthma attacks.
Benzoates, sulfur dioxide, sulfites. These are bad because they are all preservatives that have no business being in a health supplement. They all are known to stimulate allergic reactions.
Hydrogenated oils. These are the bad, sticky fats that are found in junk foods and are harmful to your child’s heart. Incredibly, some companies put hydrogenated oils in a children’s vitamin!
As you can see, our children’s chewable multivitamin is not your ordinary kids multivitamin, and it provides all the benefits of our other multivitamins in a tasty chewable format. In fact, many adults take it who prefer a chewable over a capsule or tablet. It is uniquely formulated to be scalable for adults at the dosage of two tablets per 20 lbs body weight.
Chewable Kids Mighty-Multi tastes great, provides advanced forms of nutrients, and scales up for adults.
CONCLUSION: TAKE A MULTIVITAMIN
Multivitamins are the first supplement most people need and should take. Taking a high-potency, high-purity multivitamin daily provides many benefits beyond what you might expect. This includes everything from ensuring against deficiencies to providing amounts necessary for optimal health, and for compensating for greater needs depending on your unique biochemical individuality. Given the overarching safety and relatively low cost of multivitamins, they are best “first defense” in a nutrient-depleted world.
HPDI offers four of the best multivitamins available anywhere, and five if you consider that Multi Two is available in capsules or tablets. So take your pick among them, and be the healthiest you can be.
Many in the field of nutrition have lost sight of the fact that there are two essential fatty acids needed by the body. Many people recommend omega-3 fatty acids assuming the the body gets sufficient omega-6 from the diet. The truth about essential fatty acids is more complicated. This article will show the more complete and correct picture.
Fatty acids are part of the lipids class, widely found in nature, food, and organisms. These fatty acids are a critical constituent of the cell membranes in all of the trillions of cells in the body. They have important biological functions including structural, communication, and metabolic roles, and they represent an important source of energy. Their metabolism produces a huge quantity of adenosine triphosphate (ATP). The beta-oxidation of the fatty acids is a well-known process, mostly used by the heart and the muscular tissue to obtain energy.
Figure 1 below shows a schematic diagram of what a fatty acid looks like. One end of the structure in all cases has a carboxylic acid group (COOH) and the other end in all cases has a methyl group (CH3). Saturated fats have single bonds (-) between all carbon atoms (C), but unsaturated fats have a number of double bonds (=) between some of the carbon atoms.
Figure 1 – Basic diagram of fatty acids structure
The human body can synthesize many of these fatty acids, except the essential fatty acids (PUFAs) linoleic acid (LA) and alpha-linolenic acid (ALA). These two are generally found in various vegetable oils, but their important metabolites are found mainly in special vegetable oils such as borage oil and in fish oils. Linoleic acid is the most abundant fatty acid in nature, and it is the precursor of other omega-6 fatty acids. Omega-3 fatty acids are synthesized from alpha-linolenic acid.
Once ingested, short-chain PUFAs are converted to long-chain fatty acids. These are critical for mammalian cells in order to perform various biological functions, such as sustaining the structural integrity of cellular membranes and serving as signaling molecules. They are highly enriched in brain tissues, where they participate in the development and maintenance of the central nervous system during both embryonic and adult stages.
Polyunsaturated fatty acids have been extensively researched. They include the essential fatty acids linoleic acid (an omega-6) and alpha linolenic acid (an omega-3). Omega-3s are not abundant in our food chain. There is none in corn oil and very little in soy oil, the two most widely used food oils. Therefore, nearly all the early research with polyunsaturated oils utilized omega-6 fatty acids, predominantly as linoleic acid.
Fish oils were neglected out of ignorance or because the investigators chose to pass over these cholesterol-containing oils. Concern eventually developed over the close association between increasing incidence of mammary tumors and high intake of omega-6 polyunsaturated fatty acids. After some years, researchers finally turned their investigations to the interrelationship between dietary omega-6 and omega-3 fatty acids.
FATTY ACID METABOLIC PATHWAYS
The following diagram shows in detail the pathways for the production and use of fatty acids in the body. In the figure the metabolic pathways (running left to right) for four fatty acids types are shown (top – Omega-3, second – Omega-6, third – Omega-9, bottom – Omega-7). Notice that only the omega-3 and omega-6 oils are considered to be essential fatty acids because they cannot be made in the body. This means they must come from food.
Figure 2 – fatty acid metabolism pathways in the body
The diagram shows a series of enzyme induced reactions that either add a double bond or two additional carbon/hydrogen pairs to the fatty acid. The enzymes that make this happen are called desaturase and elongase. The desaturase enzymes are given a number for the carbon number (that the enzyme is working on) from the methyl end of the fat. These same enzymes work on all of the fatty acid types. For example, Delta 6 desaturase causes an additional double bond to be inserted into both alpha-linolenic (omega-3) and linoleic acid (omega-6) (as well as oleic acid and palmitoleic acids).
In this way, the body is able to produce a wide variety of fatty acids that have their own unique effects on biochemistry. Some of these are more important than others. In particular, the omega-3 essential fatty acid eicosapentanoic acid (EPA), the omega-6 essential fatty acid dihomo-gamma-linolenic acid (DGLA), and the omega-6 essential fatty acid arachidonic acid (AA) are precursors for a class of chemicals called eicosanoids/prostaglandins that have far reaching affects on key body functions.
Eicosanoids are prostaglandins that affect many aspects of health both positively and, in some cases, negatively. All known eicosanoids and prostaglandins are formed from the essential fatty acids linoleic acid (omega-6, or n-6), alpha linolenic acid (omega-3, or n-3), their “enhanced” derivatives, and from the omega-3 fatty acids in fish oils.
Prostaglandins are short-lived highly active, hormone-like chemicals that are found in every cell of the body. They are regulators of cell activity and essential for maintaining health. Each cell type or organ produces its own form of prostaglandin to carry out its functions. There are three types of prostaglandins: PG1, PG2, and PG3.
Series 1 Prostaglandins (PG1), derived from gamma-linolenic acid (GLA), the active component of borage oil, has many beneficial effects: It makes platelets less sticky, lowers blood pressure by relaxing smooth muscles in the walls of arteries, increases loss of sodium and water, decreases inflammation and enhances immunity.
Series 2 Prostaglandins (PG2), also derived from GLA, is used in “fight or flight” (stress) situations, – the fight against danger, or the flight from it. In modern lifestyles which are high in stress but low in physical activity, continuous production of Series Two Prostaglandins results in sticky platelets, high blood pressure, increased water and sodium retention, increased inflammation and decreased immune system capabilities.
Series 3 Prostaglandins (PG3), derived from eicosapentaenoic acid (EPA), the active component of fish oil, has beneficial effects. They block the detrimental effect of the Series 2 Prostaglandins, preventing them from being made in the body. As a result the platelets are less sticky, blood pressure is lower because the muscles in the walls of our arteries remain relaxed, loss of sodium and water by the kidneys takes place more effectively, inflammation response is decreased, and immune function is efficient.
It is now known that the ratios of these dietary fatty acids are very important. Consumption of linoleic acid leads to production of the enhanced fatty acid, arachidonic acid (20:4n-6). Prostaglandins based on arachidonic acid exacerbate stress and inflammatory states, and suppress immunoprotective functions (i.e. resistance to disease). Too much linolenic acid and other omega-3s may cause excessive bleeding during injury, surgery, or childbirth. Large amounts of any of these unsaturated fatty acids in the diet without a compensatory increase in antioxidant nutrients (especially Vitamin E), can speed oxidative damage to tissues, resulting in accelerated aging while increasing the risk of degenerative diseases.
Yet, a balanced ratio of both omega-3 and omega-6 fatty acids in the diet offers very positive health benefits. When omega-3 fatty acids predominate, the body will produce less arachidonic acid (20:4n-6). Immunity improves and inflammation subsides.
Unfortunately, our Western diet has been almost devoid of omega-3 fatty acids. Creating the optimum intake of omega 3-to-omega 6 unsaturated fatty acids has become, therefore, an issue of prime importance for anyone concerned with health. We need to evaluate carefully the amounts of linoleic acid (n-6) we consume relative to our intake of alpha-linolenic acid (18:3n-3) and fish oils (EPA:20:5n-3 and DHA:22:6n-3).
ESSENTIAL FATTY ACIDS – PATHWAYS
The diagram in Figure 3 shows details of the omega-6 and omega-3 pathways. Pathway specifics indicate key eicosanoids (series 1 prostaglandins, series 2 prostaglandins, and series 3 prostaglandins), oil sources, and important nutrient cofactors that are needed for the reactions to take place.
Figure 3 – Essential Fatty Acids – pathways in the body
The information is this diagram gives the clues we need in order to provide optimal types and amounts of omega-6 and omega-3. For example, I have chosen for my essential fatty acid product cold pressed borage oil as the best natural source of gamma linoleic acid (GLA). It contains 20% by weight — the highest amount found in natural oils.
RESEARCH ON ESSENTIAL FATTY ACIDS
Work by Chapkin et. al. (see references 1–4 below) has identified the potent synergistic relationship between GLA, an omega-6 fatty acid, and the well-known omega-3 fatty acids. Chapkin has shown that, rather than simply the quantity of dietary omega-3s, it is the ratio of omega-6 to omega-3 fatty acids that is important in achieving full cardiovascular health and inflammatory control.
Furthermore, Chapkin has identified the ideal ratio. His published work deals with the importance of mixed diets supplying both linoleic and linolenic acids. To underscore the importance of these two fatty acids, refined oil supplements rich in enhanced forms were used. “Enhanced forms” are fatty acids derived from the original. They are one or more steps closer to the actual eicosanoid. In the human body, alpha linolenic acid (18:3n-3) is eventually converted to eicosapentaenoic acid (EPA, 20:5n-3) and linoleic acid (18:2n-6) is converted to gamma-linolenic (GLA, 18:3n-6) as its first enhanced form. Both enhanced fatty acids are precursors to eicosanoids.
In Chapkin’s research, superior health benefits were delivered by the mixed diet that supplied the eicosanoid precursors in a specific ratio. The balanced ratio of enhanced Omega-6 (GLA)-to-Omega-3 (EPA) fatty acids was 1:4.
IMPLEMENTATION OF THE SCIENCE
Based upon the science discussed above, I developed a product with the correct Omega-6 (GLA)-to-Omega-3 (EPA) ratio and with proper amounts. It is available to you as Hank & Brians Essential Fats Plus E from Health Products Distributors, Inc. (HPDI).
ESSENTIAL FATS PLUS E IS A HIGHLY ADVANCED ESSENTIAL FATTY ACIDS SUPPLEMENT
OFFERING SPECIAL BENEFITS:
UNIQUE COMBINATION — Essential Fats (EPA, DHA, GLA) plus Vitamin E. This unique formula offers more than one type of Vitamin E (not just d-alpha-tocopherol) and balanced essential fats.
BALANCED ESSENTIAL FATS— Many EFA supplements contain only omega-3s, but for optimal function the body requires a balance of omega-3 and omega-6 essential fats. In addition, our special formula provides a 4-to-1 ratio of EPA to GLA in order to achieve a balance you need for optimal health.
FULL-SPECTRUM VITAMIN E — Tocotrienols and tocopherols in this formula are natural vitamin E substances derived from oryza rice bran oil and protect polyunsatured EFAs against free-radical damage both in the capsule and in your body. Many Vitamin E supplements contain only d-alpha tocopherol, which is only a single component of the full-spectrum Vitamin E in this formula.
ULTRAPURE — Molecularly distilled oils of extremely high-purity containing no PCBs, heavy metals, or oxidized contaminants. Free of excipients, additives, and common food allergens!
COMPOSITION: Six softgel capsules provides the following percentages of the Daily Value.
% Daily Value†
EPA (Eicosapentaenoic Acid 20:5 omega 3)
(from 2,000 mg of purified fish oils)
DHA (docosahexaenoic Acid 22:6 omega 3)
(from 2,000 mg of purified fish oils)
Vitamin E (d-alpha-tocopherol) (from 180 mg of Oryza rice bran oil)
Mixed Tocotrienols (d-gamma, d-alpha, and d-delta)
(from 180 mg of Oryza rice bran oil)
* No established Daily Value
† Daily Values based on a 2,000 calorie diet
IMPORTANT FUNCTIONS OF ESSENTIAL FATTY ACIDS
Below we provide some of the functions and benefits obtained when by diet or supplementation the correct ratios and amounts of essential fatty acids are consumed.
• Regulate steroid production and hormone synthesis • Regulate pressure in the eyes, joints, and blood vessels • Regulate response to pain, inflammation, and swelling • Mediate Immune Response • Regulate bodily secretions and their viscosity • Dilate or constrict blood vessels • Regulate smooth muscle and autonomic reflexes • Are primary constituents of cellular membranes • Regulate the rate at which cells divide • Necessary for the transport of oxygen from the red blood cells to tissues • Necessary for proper kidney function and fluid balance • Prevent red blood cells from clumping together • Regulate nerve transmission
GENETIC TESTING AND ESSENTIAL FATTY ACIDS
Please note that genetic testing for a wide range of genes and the enzymes they produce has indicated that essential fatty acids can be an important factor in helping the body overcome a variety negative gene variations. These negative gene variations include genes that relate to: 1) Inflammatory Response, 2) Exercise Performance, 3) Exercise Recovery, 4) Cardiovascular Fitness, 5) Body Composition, and 6) VO2 Max, Aerobic Capacity.
We will discuss this more deeply in a future blog article.
The body is best protected from a range of health issues when we supply a mixed diet of both omega-3 and omega-6 essential fatty acids. Studies show that we do not need to consume large amounts of fatty acids if the ratio is correct. These findings indicate that, for a typical human body, amounts of 90 mg GLA (18:3n-6) to 360 mg EPA (20:5n-3) taken daily will provide for the optimum production of the three major prostaglandins. These amounts are found in Hank & Brians Essential Fats Plus E.
The following includes abstracts of Chapkin’s published research on essential fatty acids.
Because alterations in the dietary content of fatty acids are an important method for modulating macrophage eicosanoid production, we have quantitated the levels of n-6 and n-3 polyunsaturated fatty acids in peritoneal macrophage individual phospholipids from mice fed diets (3 wk) with either safflower oil (SAF), predominantly containing 18:2n-6, borage, (BOR) containing 18:2n-6 and 18:3n-6, fish (MFO) containing 20:5n-3 and 22:6n-3, and borage/fish mixture (MIX) containing 18:2n-6, 18:3n-6, 20:5n-3 and 22:6n-3. Dietary n-3 fatty acids were readily incorporated into macrophage phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylserine (PS) and phosphatidylinositol (PI). The increase in n-3 fatty acid levels was accompanied by a decrease in the absolute levels of 18:2n-6, 20:4n-6 and 22:4n-6 in PC, PE and PS. Interestingly, PI 20:4n-6 levels were not significantly lowered (P greater than 0.05) in MIX and MFO macrophages relative to SAF and BOR. These data demonstrate the unique ability of this phospholipid to selectively maintain its 20:4n-6 levels. In BOR and MIX animals, 20:3n-6 levels were significantly increased (P less than 0.05) in all phospholipids relative to SAF and MFO. The combination of borage and fish oils (MIX diet) produced the highest 20:3n-6/20:4n-6 ratio in all phospholipids. These data show that the macrophage eicosanoid precursor levels of 20:3n-6, 20:4n-6 and n-3 acids can be selectively manipulated through the use of specific dietary regimens. This is noteworthy because an increase in phospholipid levels of 20:3n-6 and 20:5n-3, while concomitantly reducing 20:4n-6, may have therapeutic potential in treating inflammatory disorders.
Institutional address: Department of Human Anatomy School of Medicine University of California Davis 95616.
This study examined the effects of n-3 and n-6 polyunsaturated fatty acid alimentation on murine peritoneal macrophage phospholipids. Mice were fed complete diets supplemented with either corn oil predominantly containing 18:2n-6, borage oil containing 18:2n-6 and 18:3n-6, fish/corn oil mixture containing 18:2n-6, 20:5n-3 and 22:6n-3, or fish/borage oil mixture containing 18:2n-6, 18:3n-6, 20:5n-3 and 22:6n-3. After two weeks, the fatty acid levels of glycerophosphoserines (GPS), glycerophosphoinositols (GPI), sphingomyelin (SPH), and of the glycerophosphocholine (GPC) and glycerophosphoethanolamine (GPE) phospholipid subclasses were determined. We found that mouse peritoneal macrophage GPC contain primarily 1-O-alkyl-2-acyl (range for the dietary groups, 24.6-30.5 mol %) and 1,2-diacyl (63.2-67.2 mol %), and that GPE contains 1-O- alk-1′-enyl-2-acyl (40.9-47.4 mol %) and 1,2-diacyl (44.2-51.2 mol %) subclasses. In general, fish oil feeding increased macrophage 20:5n-3, 22:5n-3 and 22:6n-3 levels while simultaneously reducing 20:4n-6 in GPS, GPI, GPE and GPC subclasses except for 1-O-alk-1′-enyl-2-acyl GPC. Administration of 18:3n-6 rich diets (borage and fish/borage mixture) resulted in the accumulation of 20:3n-6 (2-carbon elongation product of 18:3n-6) in most phospholipids. In general, the novel combination of dietary 18:3n-6 and n-3 PUFA produced the highest 20:3n-6/20:4n-6 phospholipid fatty acid ratios. This study demonstrates that marked differences in the responses of macrophage phospholipid classes and subclasses exist following dietary manipulation.
The ability of dietary gamma-linolenic acid [18:3(n-6)] to modulate prostaglandin biosynthesis in mouse resident peritoneal macrophages was determined. Mice were fed diets containing corn oil, borage oil or evening primrose oil or a mixture of borage and fish oils. After 2 wk, resident peritoneal macrophages were isolated and stimulated with unopsonized zymosan to induce prostaglandin synthesis. Borage oil, primrose oil and fish-borage oil mixture dietary groups (containing 25.6, 11.9 and 19.5 g gamma-linolenic acid/100 g fatty acids, respectively) had significantly (P less than 0.05) enhanced prostaglandin E1 synthesis (39.7, 29.4 and 73.0 nmol prostaglandin E1/mg protein, respectively) compared with corn oil-fed (containing less than 0.1 g gamma-linolenic acid/100 g fatty acids) animals, which synthesized less than 0.1 nmol prostaglandin E1/mg protein. Borage oil- and fish-borage oil mixture-fed mice had the highest biosynthetic ratio of prostaglandin E1/prostaglandin E2 (E1/E2 approximately 0.2). Macrophages from borage oil-fed mice synthesized the lowest amount of prostacyclin (198.7 nmol 6-keto-prostaglandin F1 alpha/mg protein) compared with corn oil-, primrose oil- and fish- borage oil mixture-fed mice (379.7, 764.8 and 384.2 nmol 6-keto- prostaglandin F1 alpha/mg protein, respectively). In addition, borage oil-, primrose oil- and fish-borage oil mixture-fed mice had significantly (P less than 0.05) higher levels of dihomo-gamma- linolenic acid [20:3(n-6)] in membrane phospholipids (5.5, 3.5 and 5.7 mol/100 mol, respectively) relative to corn oil-fed mice (2.0 mol/100 mol).
This study was conducted to compare the impact of dietary lipids on the ability of macrophages to modulate vascular smooth muscle cell (SMC) DNA synthesis in vitro. C57BL/6 female mice were fed six different diets (6 mice/diet) containing 10% fat from corn oil (CO), borage oil (BO), primrose oil (PO), fish-corn oil mix (FC, 9:1, w/w), fish-borage oil mix (FB, 1:3, w/w), or fish-primrose oil mix (FP, 1:3, w/w) for 2 wk. Peritoneal macrophages were isolated from these mice, stimulated with zymosan or vehicle, and subsequently co-cultured with naive mouse aortic SMC in the presence of 3H-thymidine to measure SMC DNA synthesis. In this co-culture system, macrophages were seeded on 25-mm culture inserts (upper chamber) and SMC were seeded on 35-mm culture dishes (lower chamber). The two cell types were separated by a semipermeable membrane with a 30-kD cut-off. When quiescent SMC were co-cultured with macrophages, only the PO and FP diet groups had significantly (P < 0.05) lower SMC DNA synthesis compared with the control CO group whose diet contained no gamma- linolenic acid (GLA) or (n-3) polyunsaturated fatty acids (PUFA). In contrast, when cycling SMC were co-cultured with diet-modulated macrophages, all dietary groups except for those fed FC had significantly lower (P < 0.05) SMC DNA synthesis relative to the CO group. Although the level of GLA in PO and BO diets was different (11.5 and 22.3 g/100 g fatty acids, respectively), these treatments exerted comparable inhibitory effects on SMC DNA synthesis. The FP treatment consistently exhibited the lowest SMC DNA synthetic profile among the six dietary groups irrespective of SMC growth conditions. These data suggest that BO and PO alone or in combination with fish oil influence macrophage/smooth muscle cell interactions in a manner consistent with favorable modulation of the atherogenic process.
These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.
Enig, Mary G. Know Your Fats: The Complete Primer for Understanding the Nutrition of Fats, Oils, and Cholesterol. Bethesda Press, 2000.