There’s a new kind of super-antioxidant formula in town. It will quench your free radicals in ways you never conceived. It’s called Ultimate Protector+. Its benefits are many due to a triple-action design that includes instructing cells to make their own antioxidants, a process known as Nrf2 activation. The benefits range from anti-aging and anti-inflammatory effects to support for immunity, brain function, and cardiovascular health. Your body depends on antioxidants to defend it from oxidative stressors. And Ultimate Protector+ defends you like nothing else can.
Ultimate Protector+ is among the world’s premier Nrf2 antioxidant supplements. It started when Dr. Hank realized that a triple-mode formula could best leverage the antioxidant powers available via Nrf2 activators in supplement form. That is, he could develop an ultra-effective Nrf2 activator-antioxidant formula by combining 1) non-GMO vitamin C, 2) potent exogenous (external) antioxidants from plant substances, and 3) plant-based Nrf2 transcription factor activators for endogenous (internal) antioxidant production within cells.
Dr. Hank designed Ultimate Protector+ to provide the most comprehensive antioxidant protection going beyond any supplement. The proof of his design methodology is the fact that one serving (six small capsules) of Ultimate Protector+ provides nearly 1,000,000 ORAC6.0 units. The ORAC6.0 test from Brunswick Labs measures how effectively an antioxidant can perform against six different free radicals: hydroxyl, peroxyl, peroxynitrite, singlet oxygen, superoxide anion, and hypochlorite (hypchlorous acid).
Most antioxidant supplements may effectively quench one or two types of free radicals. What makes Ultimate Protector+ different is its unique capacity to quench all six major free radicals. Ultimate Protector+ provides a significant edge in defending your body against the full spectrum of oxidants encountered in daily life.
The distinctive advantage of balanced free radical defense against a broad spectrum of oxidants distinguishes Ultimate Protector+ as a premier antioxidant and anti-aging supplement. This also makes it a “go-to” formula for supporting strong immunity, mitigating the effects of inflammation, enhancing brain function, boosting cardiovascular health, etc., as well as generally maintaining high antioxidant status in cells.
ULTIMATE PROTECTOR+ TEST RESULTS
Looking at the Brunswick Labs’ ORAC6.0 test results (from August 2019) for Ultimate Protector+, you see various oxidants (hydroxyl radical, peroxyl radical, singlet oxygen, etc.) are quenched at somewhat different levels. What is most important is that all six types are quenched, and that the total level of antioxidant protection—968,237 µmole TE/gram—is extremely high. To get an idea of how high that level of protection is, consider that a typical “good” antioxidant supplement might provide about 7,000–10,000 µmole TE/gram.
Specifically, the test results for Ultimate Protector+ show values of 3,376 µmole TE/gram for peroxyl radicals, 5,569 µmole TE/gram for hydroxyl radicals, 2,758 µmole TE/gram for peroxynitrite radicals, 221,866 µmole TE/gram for superoxide anion radicals, 34,169 µmole TE/gram for singlet oxygen radicals, and 5,005 µmole TE/gram for hypochlorite radicals. The table (below) shows for each free radical type the ORAC6.0 daily values for six capsules of Ultimate Protector+ containing 3.55 grams of the formula.
The overall daily ORAC6.0 value for six capsules (3.55 g) is obtained by adding the values for each free radical type. The total of 968,237 units is calculated by multiplying 272,743 units x 3.55 gram serving). To our knowledge there is no other Nrf2 or antioxidant formula that comes close to providing the complete protection of Ultimate Protector+ in terms of breadth of coverage and overall strength.
Ultimate Protector+ is a next generation cell protection formula that simultaneously meets the body’s needs for 1) high levels of Vitamin C, 2) full spectrum antioxidants (including polyphenols, flavonoids, anthocyanidins, oligomeric proanthocyanidins, catechins, curcuminoids, ellagic acid, pterostilbene, resveratrol, chlorogenic acid, xanthines, punicalagins, quercetin, zeaxanthin, carotenoids, polysaccharides, quinic acid, and more), and 3) many of the most protective enzyme activators (Nrf2 activators) — in a single product! This potent combination of characteristics distinguishes the formula because no other single formula available today offers such complete protection.
Ultimate Protector+ supplies nutrients that provide anti-aging, anti-inflammatory, and pain relieving effects, as well as ultra-high levels of antioxidant protection. Damage to cells caused by free-radicals contributes to many degenerative health conditions and to the aging process. This formula effectively supports the body in combating adverse effects of free-radicals.
ULTIMATE PROTECTOR+ BENEFITS
• Pain relief
• Acts to support the body regarding brain function, cardiovascular conditions, hypertension, and supports strong immunity
• Ultra powerful free radical defense. Helps prevent and mitigate free radical damage that contributes to conditions of poor health.
• Facilitates the body’s internal production of antioxidant enzymes within cells by supplying many powerful natural Nrf2 transcription factor activators
• Ultra effective, high potency, best-in-class antioxidant protection
ULTIMATE PROTECTOR+ FEATURES
• Plant Based Nrf2 Activators Potentiate the Body’s Internal Antioxidant Systems
• Ultra-High Antioxidant Potency as measured by ORAC6.0 testing to be over 968,000 micro moles TE per serving!
• Complete Formula Defends Body Against All Six Major Classes of Free Radicals including: 1) peroxyl, 2) hydroxyl, 3) peroxynitrite, 4) singlet oxygen, 5) superoxide anion, and 6) hypochlorite
• Provides 12+ Fruit- and Vegetable-Based Antioxidants and Nrf2 Activators to Offer Full Spectrum Protection
• Synergistic Formula Combines Effects of Endogenous (Internally Produced) Antioxidants, Exogenous (externally supplied) Antioxidants, and Vitamin C
• 100% non-GMO Ingredients (includes non-GMO Vitamin C)
• Contains calcium and magnesium malates supporting ATP & enzyme production
• Includes BioPerine ® a black pepper extract that significantly enhances the absorption of all of the nutrients in the formula
• Veggie Capsules (suitable for vegetarians and vegans)
• Easy to Take. Just six small capsules daily provides optimal antioxidant protection.
• Best in Class Cell Protection
ULTIMATE PROTECTOR+ INGREDIENTS
Ultimate Protector+ contains USP-grade non-GMO Vitamin C, SFB® standardized fruit blend (~50% polyphenols, high-ORAC powder: 9,000 µmole TE/g) from Grape, Cranberry, Pomegranate, Blueberry, Apple, Mangosteen, Bilberry, Chokeberry, and Goji Berry), Curcumin (standardized extract with 95% curcuminoids), Trans-Resveratrol (98% from Giant Knotweed), Green Tea Extract (93% polyphenols, 50% EGCG), VinCare® Whole Grape Extract (>80% polyphenols, ORAC>19,000 µmole TE/g), Calcium Malate, Magnesium Malate, and Bioperine® (a patented black pepper extract that enhances absorption of all ingredients and is a known Nrf2 activator).
Ultimate Protector+ is contained in a capsule suitable for vegetarians (i.e., a veggie cap) and contains no magnesium stearate.
ULTIMATE PROTECTOR+ RECAP
Ultimate Protector+ satisfies three distinct needs: 1) The need for a non-GMO Vitamin C product. That is, a Vitamin C formula that avoids genetically modified sources, 2) The need for a single powerful antioxidant formula. That is, a single, easy-to-take antioxidant formula offering a broad range of extremely high ORAC6.0 plant source #antioxidants, and 3) The need for a supplement providing a full spectrum of many of the most powerful Nrf2 activators. That is, a supplement providing a wide range of natural #Nrf2 transcription factor activators that allow the body to make its own antioxidant enzymes (e.g., superoxide dismutase (SOD), catalase, heme oxygenase, and glutathione peroxidase).
Ultimate Protector+ is an invaluable supplement for individuals requiring a high-quality, high-potency, and highly effective antioxidant supplement providing exceptionally well-rounded antioxidant protection against a broad range of free radicals. It has a unique triple action capacity to provide the nutrients required by the body for maximum free-radical defense, including plant-based Nrf2 activators that allow cells to produce their own antioxidants.
Providing nearly one million ORAC6.0 units is just one of the ways Ultimate Protector+ supports optimal health. Combining super antioxidant power with non-GMO vitamin C and Nrf2 activators makes Ultimate Protector+ an ideal choice for anyone seeking the highest levels of antioxidant protection.
The scientific evidence for Vitamin D3 continues piling up. It is abundantly clear a large percentage of the global population is deficient in Vitamin D3, and that supplements can make a huge difference for people to avoid and prevent deficiency of this critical nutrient.
During a period when people are self-isolating and mostly indoors—and there is an immediate coronavirus threat—it is time to act on the science supporting Vitamin D3.
It is now well known that Vitamin D plays critical roles in fighting viruses and building immunity. Many doctors now routinely advise patients to take high doses of Vitamin D3, especially in the winter when both Vitamin D levels and sun exposure are lowest.
“I have found the value of bolstering immune function with Vitamin D to be incredibly powerful.” – Dr. Jeffery Rutersbusch
William Grant, PhD, says: “Coronaviruses cause pneumonia as does influenza. A study of the case-fatality rate from the 1918-1919 influenza pandemic in the United States showed that most deaths were due to pneumonia. The SARS-coronavirus and the current China coronavirus were both most common in winter, when vitamin D status is lowest.” [1–5]
VITAMIN D3 PLUS
VITAMIN D3 PLUS is HPDI’s complete vitamin D3 formula. It was designed by Hank Liers, PhD to not only provide Vitamin D3, but also Vitamin K2 and Vitamin A both of which support the body’s uptake and use of Vitamin D3.
We have covered Vitamin D3 in previous posts such as Vitamin D3 Superstar! and Vitamin D3 for Health, and various other articles. In fact, Dr. Hank formulated Vitamin D3 PLUS 10 years ago, and it has become one of our best-selling products. As the general understanding that Vitamin D3 is critical for health increased, more people are taking action to supplement their diet with supplements like Vitamin D3 PLUS.
VITAMIN D3 PLUS is designed as an advanced Vitamin D formula providing high-dose Vitamin D3. Vitamin D3 is the natural form of Vitamin D produced in the body from sunlight and is the form best used for therapeutic purposes.
One softgel capsule of Vitamin D3 Plus provides 125 mcg (5,000 IU) of Vitamin D3 derived from highly purified and molecularly distilled fish liver oils. In addition, the product contains 300 mcg (1,000 IU) of Vitamin A also derived from highly purified and molecularly distilled fish liver oils and 10 mcg of Vitamin K2 from menaquinone-7.
Vitamin D3 Plus includes synergistic nutrients known to enhance absorption and use of Vitamin D3 in the body. These nutrients include Vitamin K2 (menaquinone-7) (10 mcg), which which works together with Vitamin D to help boost bone density, improve cardiovascular health, and boost immunity.
Vitamin D3 Plus also provides 300 mcg (1,000 IU) of Vitamin A, a nutrient known to work powerfully with Vitamin D to help create optimal health. As dosages of Vitamin D increase, ideally your dosage of Vitamin A also will increase, and vice versa. The formula also includes natural Vitamin E as an antioxidant.
Vitamin D3 Plus incorporates advanced softgel encapsulation
IMPORTANT VITAMIN D FACTS
In a world of sun avoidance, sun blocks, working indoors, latitudinal effects, etc., nearly the entire population suffers in multiple ways from Vitamin D3 deficiency
Human beings optimally produce 10,000–20,000 IU of Vitamin D3 (cholecalciferol) when exposed to full sunlight on a significant portion of skin for about 30 minutes
The body starts to gain the full benefits of Vitamin D3 only after it produces (or intakes orally) about 5,000 IU Daily
Vitamin D3 is a prehormone with powerful effects and with few exceptions cannot be obtained in sufficient amounts from diet
VITAMIN D3 PLUS FORMULATED FOR OPTIMAL HEALTH
Vitamin D3 is a fat-soluble vitamin increasingly known as a nutrient essential for health and well-being. Recent studies show that almost all body systems benefit from adequate Vitamin D intake/production. Therefore, it is important that the body receive optimal amounts in order to build the best health. In fact, recent studies indicate that 5,000 IU of Vitamin D3 is an ideal amount for daily intake. What is notable about this amount is that the body does not gain the full benefits from Vitamin D until it reaches this “threshold” level of about 5,000 IU. While the body stores Vitamin D, it must first be given an adequate supply.
Because Vitamin D3 is important for all body systems, the benefits of adequate Vitamin D are numerous. Adequate Vitamin D not only helps to ensure good health, but also supports the body in preventing and combating a wide range of conditions. When taken in adequate dosages (one or two 5,000 IU capsules daily), Vitamin D3 can provide the following benefits: 1) stronger bones, 2) enhanced immunity, 3) protection from autoimmune diseases, 4) improved blood sugar control, 5) normalized blood pressure, 6) prevention of tumors, 7) protection against flu, 8) better balance, 9) prevention of autism, 10) improved mood, 11) reduction of chronic pain, 12) improved dental health, 13) improved muscle strength, 14) prevention of birth defects, 15) improved prostate health, 16) better bowel health, 17) supports individuals with Multiple Sclerosis, 18) reduced symptoms of PMS, and 19) many other benefits.
The oils in Vitamin D3 Plus are emulsified by the addition of a non-GMO sunflower lecithin that ensures excellent uptake by the body. Vitamin E as tocopherols and tocotrienols derived from Oryza rice bran oil are included to protect against oxidation in the product and in the body. In addition, the rice bran oil is used to enhance the absorption of the fat-soluble Vitamin D and Vitamin A.
Vitamin D deficiency currently is a worldwide epidemic with more than one billion people at risk for diseases associated with low Vitamin D status. Vitamin D is proven safe and effective for a wide range of health conditions (see above and below). There are various reasons for this epidemic, including a significant portion of the world’s population living in northerly latitudes (where sunlight is inadequate during many months of the year), sun avoidance, time spent indoors, etc.
VITAMIN D3 MORE EFFECTIVE THAN D2
Vitamin D3 Plus provides only the Vitamin D3 form of Vitamin D. We avoid the use of Vitamin D2. Vitamin D2 has greater potential for toxicity, poorer absorption, and reduced effectiveness. Vitamin D3 is the preferred form of Vitamin D…and the form that gives you the best health.
VITAMIN D3 PLUS FROM HIGHLY PURIFIED FISH LIVER OIL
Vitamin D3 Plus provides Vitamin D3 from purified fish (cod) liver oil. Our formula comes in a softgel (instead of a standard capsule) for greater purity. In a softgel, the oil does not contain other ingredients (like cornstarch) commonly used to microencapsulate Vitamin D oil into powders used in capsule forms. The softgel form allows us to avoid using undesirable fillers and excipients. This means you avoid undesirable additives.
VITAMIN D3 PLUS OFFERS SUPERIOR ABSORPTION
Vitamin D3 PLUS includes non-GMO sunflower lecithin to act as an emulsifier of Vitamin D thereby ensuring effective absorption. In addition, the use of rice bran oil further supports absorption of fat-soluble Vitamin D. Optimizing absorption of Vitamin D is critical especially in cases of Crohn’s disease, Celiac disease (gluten intolerance), and irritable bowel syndrome. In these conditions, individuals often suffer from osteoporosis, kidney disease, etc. Better absorption means greater effectiveness.
NATURAL FORMS OF VITAMIN E PREVENT OXIDATION
Vitamin D3 PLUS includes Orzya rice bran oil because the fish liver oils in the formula are susceptible to oxidation. Oryza rice bran oil provides significant amounts of Vitamin E in the form of mixed tocotrienols and tocopherols, which are powerful antioxidants. These forms of Vitamin protect the product and keep Vitamin D3 Plus fresh, and act as powerful antioxidants in the body.
VITAMIN D3 PLUS INCLUDES VITAMIN A
Vitamin D3 Plus includes 300 mcg (1,000 IU) of Vitamin A along with Vitamin D3. We include Vitamin A because it is known that Vitamin A and Vitamin D act synergistically. Normal bone remodeling requires both Vitamin A and Vitamin D. In addition, when Vitamin D levels are inadequate, high dose Vitamin A may cause bone loss. However, no observed bone loss occurs when there are adequate levels of Vitamin D (more than 2,000 IU daily). Chris Masterjohn discusses the topic in his seminal article “Vitamin A on Trial: Does Vitamin A Cause Osteoporosis?” (see Weston A. Price Foundation website). Masterjohn states that Vitamin A taken in conjunction with Vitamin D is required for proper bone remodeling in the body. Vitamin A and Vitamin D not only act synergistically in the body, but also when taken together ensure protection from the effects of taking either one alone in high doses.
VITAMIN K2 REQUIRED FOR VITAMIN D FUNCTION
Vitamin D3 Plus includes 10 mcg of Vitamin K2 (the menaquinone-7 or MK-7 form) per softgel in our formula. Vitamin K2 (especially as MK-7) is necessary for the proper activation of bone matrix proteins by conferring on them the physical ability to bind calcium (i.e., to build strong bones). Research also shows that Vitamin K2 can help remove calcium from soft tissues in the body and instead put the calcium into bony structures (i.e., where it serves to build a strong skeletal system). Vitamin D3 Plus can help put the health-building powers of Vitamin K2 (as menaquinone-7) to work for optimal health.
Chris Masterjohn elegantly discusses the role of Vitamin K2 in bone formation in his groundbreaking article “On the Trail of the Elusive X-Factor: A Sixty-Two-Year-Old Mystery Finally Solved” (see Weston A. Price Foundation website). Because Vitamin K2 is needed to facilitate the function of Vitamin D in proper bone formation (including tooth structure), Masterjohn states that Vitamin D toxicity is most likely a case of Vitamin K2 deficiency. It is clear that adequate Vitamin K2 both protects against Vitamin D toxicity and supports the effective use of Vitamin D in the body.
In Health Benefits of Vitamin K-2: A Revolutionary Natural Treatment for Heart Disease and Bone Loss (2006), Larry Howard and Anthony Payne, PhD, assert that as little as 6 mcg (micrograms) of Vitamin K2 (as MK-7) can be beneficial. The half-life of Vitamin K2 (as MK-7) is about three days in the body. This means that as few as 6 mcg of Vitamin K2 is beneficial because the levels increase by a factor of three when its taken regularly.
It is notable that Vitamin K2 is found naturally in fermented foods, including some cheeses, sauerkraut, natto (i.e., a traditional Japanese dish of fermented soybeans), and in dairy products, eggs, and certain meats. However, the vast majority of individuals in the world do not receive adequate amounts of Vitamin K2 from their diets. Now anyone can gain the important benefits of Vitamin K2 along with the benefits of Vitamin D and Vitamin A by taking Vitamin D3 Plus.
Vitamin D is known as the sunshine vitamin.
VITAMIN D3 PLUS
NUTRITIONAL CONSIDERATIONS AND APPLICATIONS
Vitamin D, calciferol, is a fat-soluble vitamin. It is found naturally in some animal foods, but also can be made in the body after exposure to ultraviolet rays from the sun. It is known that season, latitude, time of day, cloud cover, smog, and use of sunscreens affect UV ray exposure. For example, in northern areas of the US the average amount of sunlight from November through February is insufficient to produce significant Vitamin D synthesis in the skin. Sunscreens with a sun protection factor (SPF) of 8 or greater will block UV rays that produce Vitamin D even in regions of the US where sunlight is plentiful.
The liver and kidney help convert vitamin D to its active hormone form. The major biologic function of Vitamin D is maintaining normal blood levels of calcium and phosphorus. Vitamin D aids in the absorption of calcium, helping to form and maintain strong bones. It promotes bone mineralization in conjunction with a number of other vitamins, minerals (especially magnesium), and hormones. While adequate sun exposure is an ideal means to obtain Vitamin D, most of the population cannot obtain sufficient sunlight during fall and winter months to maintain optimal Vitamin D levels. Vitamin D3 Plus offers a solution for keeping Vitamin D at optimal levels for health.
When there is insufficient Vitamin D in the body, bones can become thin, brittle, soft, or misshapen. Vitamin D prevents rickets (in children) and osteomalacia (softening of bones) (in adults). These skeletal diseases result in defects that can severely weaken bones. It is estimated that over 25 million adults in the United States either have developed osteoporosis or are at risk of developing it. Osteoporosis is a disease characterized by fragile bones. It results in increased risk of bone fractures. Vitamin D deficiency was recognized as the cause of rickets and osteomalacia 75 years ago. The prevention and cure of these diseases with fish liver oil was a triumph for nutritional science and since then the body’s requirement for Vitamin D has been linked to these conditions.
Vitamin D deficiency also has been associated with greater incidence of hip fractures. In older women, a higher Vitamin D intake from diet and supplements is associated with less bone loss. Vitamin D supplementation therefore may help prevent fractures resulting from osteoporosis and the loss of bone. Vitamin D supplements offer a significant means for strengthening bones and skeletal structures, and for preventing bone weakness or bone loss leading to osteomalacia, osteoporosis, and other conditions related to weak bones.
VITAMIN D SERVES MANY FUNCTIONS
Vitamin D affects major aspects of human health beyond its classical role in mineral metabolism. It is well established that the active form of Vitamin D acts an effective regulator of cell growth and differentiation in a number of different cell types. Laboratory, animal, and epidemiologic evidence strongly suggest that Vitamin D may be protective against some tumorigenesis. The active form of Vitamin D therefore plays a critical role in supporting good health.
Vitamin D deficiency has been associated with insulin deficiency and insulin resistance. It was shown recently that Vitamin D deficiency is likely a major factor for the development of type 1 diabetes in children. Insulin resistance is also one of the major factors leading not only to tumor formation, but also to heart disease—by far the leading cause of death in the USA. Northern countries have higher levels of heart disease and more heart attacks occur in the winter months.
Degenerative arthritis of the knee and hip progresses more rapidly in people who have lower concentrations of Vitamin D. Infertility is associated with low levels of Vitamin D, and PMS has been completely reversed by the addition of calcium, magnesium, and Vitamin D. Activated Vitamin D in the adrenal gland regulates tyrosine hydroxylase, the rate limiting enzyme necessary for the production of dopamine, epinephrine, and norepinephrine. Low Vitamin D levels also may contribute to chronic fatigue and depression. Seasonal Affective Disorder (SAD) has been treated successfully with Vitamin D.
Multiple Sclerosis, Sjogren’s Syndrome, rheumatoid arthritis, thyroiditis and Crohn’s disease have all been linked with low Vitamin D levels. It has been shown that long term low-level exposure to sunlight normalizes immune function and enhances immune cell production. This reduces abnormal inflammatory responses, such as those found in autoimmune disorders, and reduces occurrences of infectious disease.
Vitamin D deficiency also has been linked with obesity. Vitamin D recently has been shown to lower leptin secretion. Leptin is a hormone produced by fat cells and is involved in weight regulation. Obesity itself lessens the bioavailability of Vitamin D from skin and dietary sources because it is deposited in body fat. Vitamin D deficiency, moreover, has been clearly linked with Syndrome X (also known as Metabolic Syndrome). Syndrome X refers to a cluster of health conditions that includes insulin resistance (the inability to effectively process dietary carbohydrates and sugars), abnormal blood fats (e.g., elevated cholesterol and triglycerides), high blood pressure, and obesity.
VITAMIN A BENEFITS
Vitamin A is useful for many health conditions, including vision problems, poor thyroid function, and weakened immunity. Vitamin A is highly effective against infections (especially those that involve the mucous membranes) largely because it is critical to the formation of tissues lining the digestive, respiratory, reproductive, and urinary tracts. It is also required for the digestion of protein, and for lactation, reproduction, healthy skin and eyes, and the formation of steroid hormones. Vitamin A deficiency can result in a number of health problems, including night blindness, dry eyes, eye infections, and skin conditions. Vitamin A works together with Vitamin D and Vitamin K2 to maintain healthy bones. Vitamin D has been shown to prevent Vitamin A toxicity.Vitamin D3 Plus includes Vitamin A because Vitamin A and Vitamin D work together to support health.
VITAMIN K2 BENEFITS
Vitamin K2 in the form of MK-7 has been shown in numerous studies to extract calcium from the blood and arteries and deposit calcium into growing or aging bones. In addition, MK-7 appears to have the potential to prevent or even reverse some forms of heart disease and, at the same time, do the same for bone loss. It is believed that patients would be able to be treated with doses of vitamin D that possess greater therapeutic value than those currently being used while avoiding the risk of adverse effects by administering Vitamin D together with Vitamins A and K2. Vitamin D3 Plus includes Vitamin K2 (as MK-7) because MK-7 provides unique benefits for health that complement the benefits offered by Vitamin D. They act synergistically to provide other benefits beyond the benefits each by itself can provide.
VITAMIN D3 PLUS INFORMATION
COMPOSITION: One softgel capsule of VITAMIN D3 PLUS provides the following percentages of the US Daily Value for adults:
RECOMMENDATIONS: Recent research on Vitamin D suggests that most people will benefit from 125 mcg (5,000 IU) of Vitamin D3 daily (unless there is some constraining lifestyle factor or medical reason). Due to its long half-life (about 30 days) in the body, Vitamin D can be taken effectively in smaller doses if needed (e.g., 5,000 IU taken fewer times per week). For example, taking one capsule once per week would give a daily equivalent dose of about 714 IU (i.e., 5,000 IU divided by seven days).
Additional important nutrients you need to take with Vitamin D3 in order to achieve maximum benefits include magnesium, calcium, zinc, and boron. These additional nutrients are included in our foundational supplements (multivitamins, essential fats, Vitamin C formulas, and Rejuvenate!™ superfoods) and bone formulas (Bone Jour!™ and Bone Guardian).
DIRECTIONS: As a dietary supplement take one capsule of Vitamin D3 Plus daily with food, or as directed by a health care professional. Note: when exposure to direct sunlight is adequate, your requirements for supplemental Vitamin D may be correspondingly lower.
INGREDIENTS: Fish liver oil (providing Vitamin D3), bovine source gelatin (shell), glycerin (shell), yellow beeswax (shell), purified water (shell), rice bran oil, non-GMO sunflower lecithin, Oryza oil, turmeric powder (shell), Vitamin K2 (menaquinone-7), and fish liver oil (providing Vitamin A).
VITAMIN D3 PLUS does not contain wheat, rye, oats, corn, barley, soy, gluten, sugar, wax, egg, yeast, dairy, GMOs, sulfates, chlorides, coloring agents, or artificial preservatives.
2. Grant WB, Giovannucci E. (2009) The possible roles of solar ultraviolet-B radiation and vitamin D in reducing case-fatality rates from the 1918-1919 influenza pandemic in the United States. Dermatoendocrinol. 1:215-219. https://www.ncbi.nlm.nih.gov/pubmed/20592793.
3. Martineau AR, Jolliffe DA, Hooper RL et al. (2017) Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data. BMJ. 356:i6583. https://www.ncbi.nlm.nih.gov/pubmed/28202713.
5. Zhu N, Zhang D, Wang W, et al., China Novel Coronavirus Investigating and Research Team. (2020) A Novel Coronavirus from Patients with Pneumonia in China, 2019. N Engl J Med. 2020 Jan 24. doi: 10.1056/NEJMoa2001017. [Epub ahead of print] https://www.ncbi.nlm.nih.gov/pubmed/31978945.
I am excited to announce Health Products Distributors is introducing a new website for high-quality hemp extracts and CBD formulas, including liposomal formulas from Quicksilver Scientific. Our new site is: IntegratedHealthHemp.com.
We at Health Products Distributors (HPDI) offer many types of nutritional supplements on our regular website (www.IntegratedHealth.com) since 1997. We devote our new hemp and CBD website to providing only top-of-the-line hemp extracts and CBD formulas.
The new website will carry a full range of highest-quality hemp extracts and CBD products. We currently offer two liposomal hemp extracts and three CBD Synergies products (all from Quicksilver Scientific, Inc.), and our brand new Soothe & Ease DMSO and hemp topical spray formula (from QTaneous). Here is a look at the current products on IntegratedHealthHemp.com.
• Superior nanoemulsified liposomal delivery. Quicksilver Delivery Systems™ phospholipid encapsulation system brings the power of intravenous delivery into convenient oral ingestion.
• 0% THC – Ideal for anyone subject to drug testing. The psychoactive part of the industrial hemp plant is totally removed (no THC) in this formula
• This delivery system improves upon liposomal technology with smaller, more stable, single-layer spheres made from the highest-grade ingredients available. In addition to exceptional absorption rates, nanospheres like the ones produced by Quicksilver Scientific have demonstrated the ability to cross the blood-brain barrier, deposit their cargo intracellularly, and enhance lymphatic circulation of nutrients.
• The phospholipids that compose the liposome shell feed the cell membranes helping ensure the proper function for the absorption of the nutrient and excretion of the cellular waste products and toxins
QUICKSILVER NANOEMULSIFIED FULL SPECTRUM HEMP EXTRACT 400 (<.3% THC):
• Superior nanoemulsified liposomal delivery system allows for precise dosing and immediate effects. Quicksilver Delivery Systems™ phospholipid encapsulation system brings the power of intravenous delivery into convenient oral ingestion.
• Low THC (less than 0.3%). The small amount of THC (<0.3%) in this full spectrum product can actually postively enhance the functioning of the body’s endocannabinoid system. In this regard, the full spectrum product is preferable to the broad spectrum product, if you are not subject to drug testing for THC.
• Cannabidiol and associated components of the hemp extract interact with our body’s naturally occurring endocannabinoid system to aid with pain relief and enhanced feelings of well being.
• Due to known interaction of cannabidiol with endocannabinoid system receptors, much new research centers on cannabidiol’s receptor-mediated neuroprotective, antiemetic, and analgesic properties, and of its effect on mood and other aspects of mental health
• The delivery system improves upon liposomal technology with smaller, more stable, single-layer spheres made from the highest-grade ingredients available. In addition to exceptional absorption rates, nanospheres like the ones produced by Quicksilver Scientific have demonstrated the ability to cross the blood-brain barrier, deposit their cargo intracellularly, and enhance lymphatic circulation of nutrients.
• The phospholipids that compose the liposome shell feed the cell membranes helping ensure the proper function for the absorption of the nutrient and excretion of the cellular waste products and toxins
• Full-spectrum hemp extract, a combination of CBD and a Farm Bill-compliant level of THC, regulates signaling pathways throughout the body to ease discomfort from head to toe
• Softgel capsule form self emulsifies in the body allowing for rapid effects via superior liposomal delivery
• Soothing effects are bolstered by β-caryophyllene, a unique hemp-based terpene
• Curcumin complex and boswellia extract work synergistically to alleviate gut and joint irritations, while piperine, an extract of black pepper, boosts the bioavailability of each element of our formula.
SOOTHE & EASE Formula (Topical DMSO and Hemp Extract)
• Unique spray topical with hemp extract and DMSO plus herbal ingredients
• Spray and/or rub directly on skin to support muscles, joints, and skin
• Acts rapidly and effectively to soothe and ease
• Ideal for home use, sports, or travel on-the-go
Hello, this is Dr. Hank Liers from Health Products Distributors, Inc. (HPDI). Today we introduce a new website: http://www.IntegratedHealthHemp.com. The purpose of this site is really to bring into one place some of the top of the line hemp extracts / CBD products available on the market today.
I would like to talk about the difference between “broad spectrum” hemp extract and “full spectrum” hemp extract. Both of those extracts are derived from the industrial hemp plant. When you do the extracts, the nature of the extract of the industrial hemp plant is that is has a THC level of less than 0.3%. This is not enough to cause “highs” or any problems. However, from a drug testing point of view, even if there is 0.2% THC in a hemp extract and someone takes it every day, it builds up in the body, and you might fail a drug test.
The industry has defined two levels. One is called a broad spectrum hemp extract and one is called full spectrum hemp extract. In the case of the broad spectrum hemp extract, there is further processing of the product so that THC is totally removed. In the case of the full spectrum hemp extract, there is no further processing, so you have small amounts of THC along with all the other ingredients, the cannabinoids and terpenes. In fact, from a full spectrum hemp extract, you tend to get a more effective product, but then you are in the position of perhaps not passing a drug test.
As we go through discussions of the products, you will see there are products in which we have broad spectrum hemp extract and products that have the full spectrum hemp extract, so you have choices to make. Still, with extremely effective products.
I would like to give an overview of products we carry on the new website. We have seven products. Five of them we buy from a company called Quicksilver Scientific. The reason we do is that they have a very special technology for delivering ingredients into the body that is beyond the typical oral supplement. This is called a “liposomal delivery system” where you actually pack the ingredients into a #liposome, which is very small, and can actually be absorbed through the tissues of the mouth and upper GI tract to get into the body very quickly and efficiently.
One of the reasons we love these Quicksilver Scientific (QS) products so much is that you might be able to get, for example, up to seven times more into your system within the time period of a few minutes. When you can do that, because you can get so much more in effectively, you don’t have to use as much in the first place. And secondly, because it goes in so quickly, you begin to get the effects and the benefits almost immediately.
The next group of products I want to talk about are products Quicksilver just introduced, and they are called the CBD Synergies products. One of the things I like about these CBD Synergies products is where you combine the effects of the CBD and hemp extract with synergistic ingredients that give you a broader range of applicability and effectiveness.
Health Products Distributors, Inc. (HPDI) has helped people create health naturally since 1988. Our main website (http://www.IntegratedHealth.com) since 1997 is a major resource for individuals striving to live healthfully and provides information and products formulated to support optimal health. The new website for hemp extracts and CBD products is intended to complement the products on the main HPDI website.
Today I talk about two new hemp extracts available from HPDI in the Quicksilver brand. I specifically present the difference between two new products: Nanoemulsified Broad Spectrum Hemp Extract 400 and Nanoemulsified Full Spectrum Hemp Extract 400. These two products replace the single product known as “Colorado Hemp Oil” previously available from Quicksilver. We now offer these two products and a range of hemp and CBD formulas on our new hemp website: www.INTEGRATEDHEALTHHEMP.COM.
Quicksilver Scientific replaces its Colorado Hemp Oil with two superb hemp extract formulas. The new formulas (Broad Spectrum and Full Spectrum) are similar. They both have the same level (21 mg) per serving of hemp extract. Also, they both contain 16 mg cannabidiol, which is an increase from the 12 mg cannabidiol in the old product (Colorado Hemp Oil).
In addition, both of the new hemp extract formulas contain more ingredients associated with hemp extracts—including additional cannabinoids, terpenes, and beta-caryophyllene—that improve the effectiveness of hemp extract products.
For people tho are regular tested for drugs (e.g., THC), the Broad Spectrum Hemp Extract is recommended. For those individuals who are not drug tested, the Full Spectrum Hemp Extract is recommended because it will better support the functioning of the endocannabinoid system.
The price of the Nanoemusified Full Spectrum Hemp Extract 400 and the Nanoemusified Broad Spectrum Hemp Extract 400 hemp extract products remain the same as the price for the discontinued Nanoemulsified Colorado Hemp Oil product. HPDI currently sells each of these new hemp extract liposomal products for $78.50 (retail).
These two new Quicksilver Scientific hemp extract formulas are superior liposomal hemp extract products. Both Broad Spectrum Hemp Extract and Full Spectrum Hemp Extract are highly effective formulas utilizing unique nanoemulsification technology to maximize the many known benefits of hemp extract.
Ultimate Protector+ includes green tea extract, as well as extracts from 12 different fruits, vegetables, and herbs. Each of these ingredients contain substances that may be considered to be polyphenols, antioxidants, and Nrf2 activators. In this article, I explore the ingredient green tea extract. Green tea extract is added as a separate ingredient in Ultimate Protector+.
Ultimate Protector+ Includes Green Tea Extract
Green tea extract (high in EGCG) is obtained from the unfermented leaves of Camellia sinensis for which numerous biological activities have been reported including: antimutagenic, antibacterial, hypocholesterolemic, antioxidant, and protective against tumorigenesis.
The green tea extract in Ultimate Protector+ has been extracted with non-GMO food grade ethanol and distilled water. Testing has indicated the product over 93% polyphenols, over 50% EGCG, and about 4% caffeine.
Bioactive Compounds in Tea Tea contains over 2,000 components, including polyphenols (flavonoids), pigments (carotenoids and chlorophyll), alkaloids (caffeine, theophylline, theobromine), lignans, carbohydrates, lipids, proteins, amino acids (including L-theanine), vitamins (vitamin C, vitamin E, riboflavin), and various minerals and trace elements.
Flavonoids in Green Tea
Dietary flavonoids are divided in six subclasses: flavan-3-ols, anthocyanidins, flavanones, flavonols, flavones, and isoflavones. Total flavonoid content in green tea is about 138 mg a per 100 mL. A major subclass of flavonoids in green tea is that of flavan-3-ols. Flavan-3-ol monomers, also known as catechins, constitute 30%-42% of the solid weight of brewed green tea. The principal catechins found in tea are (-)-epicatechin (EC), (-)-epigallocatechin (EGC), (-)-epicatechin gallate (ECG), and (-)-epigallocatechin gallate (EGCG).
EGCG (Epigallocatechin Gallate) is one of the most powerful compounds in green tea. It has been studied to treat various diseases and may be one of the main reasons green tea has such powerful medicinal properties
Green Tea Plant
GREEN TEA STUDIES
Below we provide information from several research articles that highlight some of the potential health effects of green tea extracts.
1. EGCG upregulates phase-2 detoxifying and antioxidant enzymes via the Nrf2 signaling pathway in human breast epithelial cells
There are multiple lines of compelling evidence from epidemiologic and laboratory studies supporting that frequent consumption of green tea is inversely associated with the risk of several types of human cancer and other chronic diseases. The chemopreventive and chemoprotective activity of green tea have been attributed to the polyphenolic ingredient (-)epigallocatechin-3-gallate (EGCG). Oxidative DNA damage has been implicated in initiation of carcinogenesis. The induction of phase-2 detoxifying or antioxidant defense enzymes contributes to the cancer chemopreventive and cytoprotective effects of many phytochemicals against oxidative stress. Here, we report that treatment of human breast epithelial (MCF10A) cells with EGCG induces the mRNA expression of both modulatory and catalytic subunits of γ-glutamate-cystein ligase (GCL), which is the rate-limiting enzyme in the synthesis of GSH. In addition, EGCG upregulated the expression of other antioxidant enzymes, including manganese superoxide dismutase and glutathione S-transferase π in a concentration- and time-dependent manner. NF-E2-related factor (Nrf2), a basic-leucine zipper transcription factor, has been reported to regulate the antioxidant/electrophile responsive elements (ARE/EpRE)-mediated expression of various phase-2 detoxifying or antioxidant enzymes. The nuclear accumulation and ARE/EpRE binding of Nrf2 were increased in EGCG-treated MCF10A cells. Moreover, MCF10A cells transfected with the luciferase reporter gene under the control of ARE/EpRE-driven promoter exhibited a strong transcriptional activity following exposure to EGCG. In contrast, mutation of the GC core box in the ARE/EpRE-driven promoter abolished the EGCG-induced transcriptional activity. MCF10A cells transiently transfected with dominant negative Nrf-2 were less responsive to EGCG-induced expression of GCLC mRNA compared to the vector-transfected control cells. Furthermore, EGCG treatment activated the extracellular signal-regulated protein kinase1/2 and Akt through phosphorylation. These findings, taken together, suggest that induction of antioxidant enzymes by EGCG can be mediated by activation of Nrf2 and possibly upstream signaling kinases, which may provide the cells with acquired antioxidant defense capacity against oxidative insult.
2. Neurological mechanisms of green tea polyphenols in Alzheimer’s and Parkinson’s diseases
Abstract Tea consumption is varying its status from a mere ancient beverage and a lifestyle habit, to a nutrient endowed with possible prospective neurobiological–pharmacological actions beneficial to human health. Accumulating evidence suggest that oxidative stress resulting in reactive oxygen species generation and inflammation play a pivotal role in neurodegenerative diseases, supporting the implementation of radical scavengers, transition metal (e.g., iron and copper) chelators, and nonvitamin natural antioxidant polyphenols in the clinic. These observations are in line with the current view that polyphenolic dietary supplementation may have an impact on cognitive deficits in individuals of advanced age. As a consequence, green tea polyphenols are now being considered as therapeutic agents in well controlled epidemiological studies, aimed to alter brain aging processes and to serve as possible neuroprotective agents in progressive neurodegenerative disorders such as Parkinson’s and Alzheimer’s diseases. In particular, literature on the putative novel neuroprotective mechanism of the major green tea polyphenol, (−)-epigallocatechin-3-gallate (EGCG), are examined and discussed in this review.
Abstract Diabetic nephropathy is a complication of diabetes mellitus leading to end-stage renal disease. Oxidative stress and inflammation play a major role in the pathogenesis of diabetic nephropathy. Green tea, known for its antioxidant and anti-inflammatory properties, has been shown to be renoprotective. We hypothesized that (+)-catechin (CTN), a component of green tea, is responsible for the renoprotection. Our investigation of the therapeutic potential of CTN in streptozotocin-induced diabetic rats demonstrated for the first time that the effects of CTN treatment were comparable with the effects of an angiotensin-converting enzyme inhibitor (ACEi) enalapril for the treatment of albumin excretion. After 12 weeks of CTN treatment with 35 mg/d in the drinking water, urinary albumin excretion and plasma creatinine concentrations in all the diabetic treatment groups were reduced, compared with the diabetic group with no treatment. Urine creatinine and creatinine clearance were higher in diabetic groups treated with CTN and ACEi compared with the diabetic group with no treatment. Endothelin 1, lipid peroxidation, concentration of alanine transferase enzyme, and expression of fibronectin were lower in all the treatment groups compared with the diabetic group with no treatment. Concentrations of free thiols were higher in the CTN-treated group compared with the diabetic rats with no treatment. Our findings suggest that CTN has renoprotective properties comparable with ACEi, and coadministration of CTN and enalapril might be useful in reducing albumin excretion as well as improving endothelial function. (+)-Catechin might be successfully used in the future for clinical situations where ACEi is poorly tolerated or contraindicated.
4. Green Tea Polyphenol (−)-Epigallocatechin-3-Gallate Restores Nrf2 Activity and Ameliorates Crescentic Glomerulonephritis
Abstract Crescentic glomerulonephritis (GN) is the most severe form of GN and is associated with significant morbidity and mortality despite aggressive immunotherapy with steroids, cytotoxic drugs, and plasmapheresis. We examined the therapeutic efficacy of the green tea polyphenol (−)-epigallocatechin-3-gallate (EGCG, 50 mg/kg BW/day x3weeks), a potent anti-inflammatory and anti-oxidant agent, on experimental crescentic GN induced in 129/svJ mice by administration of rabbit anti-mouse glomerular basement membrane sera. Routine histology and key molecules involved in inflammatory and redox signaling were studied. EGCG treatment significantly reduced mortality, decreased proteinuria and serum creatinine, and markedly improved renal histology when compared with vehicle-treated mice. The improvements in renal function and histology were accompanied by the restoration of Nrf2 signaling (which was impaired in vehicle-treated mice) as shown by increased nuclear translocation of Nrf2 and cytoplasmic glutamate cysteine ligase catalytic subunit, glutamate cysteine ligase modifier subunit, and glutathione peroxidase. EGCG-treated mice also showed reduction in p-Akt, p-JNK, p-ERK1/2 and p-P38 as well as restoration of PPARγ and SIRT1 levels. Lower dose of EGCG (25 mg/kg BW/day x2 weeks) treatment also significantly decreased proteinuria and serum creatinine, and markedly improved renal histology when compared with vehicle-treated mice. Thus, our data illustrate the efficacy of EGCG in reversing the progression of crescentic GN in mice by targeting multiple signaling and inflammatory pathways as well as countering oxidative stress.
Green Tea Extract is an exciting natural ingredient full of important polyphenols, catechins, antioxidants, and Nrf2 activators that help to make Ultimate Protector such an outstanding nutritional supplement. Continued research shows an amazing list of health benefits for this substance including its ability to function as a powerful stimulator of Nrf2 activity. It truly belongs in the Ultimate Protector+™ formula.