Today I make a tasty smoothie with the new, improved REJUVENATE!™ BERRIES & HERBS superfood. In fact, Rejuvenate! Berries & Herbs is likely the most delicious among HPDI’s Rejuvenate! superfoods, as it contains for types of real organic berries: Blueberries, Strawberries, Raspberries, and Cranberries. This uber-berry superfood was born for smoothies.
Rejuvenate! Berries & Herbs is a uniquely healthy superfood that not only tastes amazingly good, but its high berry content gives it an ultra-high antioxidant value (ORAC) of 14,270 units per serving—an exceedingly high ORAC value compared to typical “superfood” formulas.
Rejuvenate! Berries & Herbs provides 14.6 gm of organic protein (including organic pea and organic rice). It includes a potent cell-protective herbal complex (including green tea extract, ginger, turmeric, astragalus, burdock, dandelion, and rhodiola). In addition, it contains a built-in multivitamin sub-formula including coenzyme vitamins and other highly assimilable forms of important micronutrients.
I especially love Rejuvenate! Berries & Herbs because my father Dr. Hank Liers formulated it to provide the most dietary nucleic acids per serving—390 mg (dietary RNA/DNA)—the most per serving in any Rejuvenate! superfood. Sources of dietary nucleic acids in Rejuvenate! Berries & Herbs include nutritional yeast, yeast extracts, and CGF (chlorella growth factor).
Dietary nucleic acids are proven to provide significant benefits for health. Studies by pioneering nucleic acid researcher Benjamin S. Frank, MD, PhD indicate effects such as greater endurance, easier breathing (anti-anoxic effect), increased energy (ATP production), improved functional strength, warmer body temperature (e.g., cold resistance), and other effects. Dr. Frank asserts that dietary nucleic acids are essential nutrients, not unlike vitamins and minerals (Dietary Nucleic Acid Nutrition & Therapy).
Considering all the benefits conferred by dietary nucleic acids, you really cannot go wrong by consuming more of them daily. And Rejuvenate! Berries & Herbs helps you do that by providing nearly 400 mg of dietary RNA/DNA per serving. That is a therapeutic dose which means you stand to gain all the benefits they confer. Depending on who you are and your health status, that could mean a lot in terms of helping you be healthier.
In sum, Rejuvenate! Berries & Herbs uniquely offers: 1) High RNA (dietary nucleic acids), 2) High Antioxidant Levels, 3) Herbal Sub-Formula, 4) High Protein, 5) Built-in Multivitamin, and 6) SUPER TASTE—that is super delicious in your superfood smoothies.
You just cannot get all these benefits in ANY other superfood, including other Rejuvenate! superfoods, each of which is formulated with a specific purpose. For example, Rejuvenate! PLUS is designed to provide significant levels of greens (think chlorella and spirulina), but lacks berries. Within its berry bailiwick, Rejuvenate! Berries & Herbs truly stands alone as one-of-a-kind.
REJUVENATE! BERRIES & HERBS highlights:
• Delicious Berry Flavor Bursts with Real Organic Berries (blueberries, strawberries, raspberries, cranberries)! • Powerful Organic and Wildcrafted Cell-Protective Herbs • High Antioxidant (ORAC) Value of 14,270 units per serving! • Contains Multiple Prebiotics Supporting Your Microbiome • Suitable for Vegetarians and Vegans & Gluten Free • Mixes Well with other Rejuvenate!™ superfoods (like Rejuvenate! PLUS and Rejuvenate! Original Greens) and smoothie ingredients.
New, improved REJUVENATE! Berries & Herbs features (per serving): • 14.6 g protein • Very little sugar (1.2 g total) • 7.0 g more fiber (13 g total) • 100 mg of organic BiAloe® aloe vera gel powder with over 18% acemannan • 700 mcg of folate as 5-MTHF • Smooth texture & delicious taste!
There you have it. If you’re anything like me—and you love the taste of real, organic berries—consider Rejuvenate! Berries & Herbs to be your greatest ally when it comes it to tasty and healthy superfood nutrition. Make yourself a Berries & Herbs smoothie, and start creating health naturally today! ~
Warrior Mist™ is the most effective formula for pain relief offered by HPDI. Warrior Mist is an all-natural, fast-acting, topical pain reliever that is effective for many types of pain. I should know. I have used it nearly every day—for years!
Types of pain Warrior Mist is known to stop, reduce, or soothe include: back pain (including sciatica), knee pain, carpal tunnel syndrome, headaches (including migraines), neck pain and tension, stiff and painful (or pulled) muscles, plantar fascitis, arthritis, sports injuries, old injuries, sprains and strains, bruises (including deep bruises), shin splints, tennis elbow, nerve pain, and post surgery pain.
Practicing aikido for years, I have a frequent need for the rapid effects of Warrior Mist. Having used it for regularly for a long time, I appreciate how quickly it relieves pain like joint pain or sprains. It also works spectacularly for bruises, cuts, abrasions, burns, bug bites, and many other applications.
TESTIMONIAL: "This really works. I had tried several other products, including prescription medications, and little success. There was a noticeable difference after my first use of the product." – Amazon customer
Warrior Mist comes in a convenient one-ounce spray bottle. I shake the bottle and then add a few pumps—or as many as I need—to my non-pumping hand and rub onto the affected area. You can also spray it directly onto skin before rubbing it in with a clean hand. If you need more, you can always unscrew the cap and pour directly into your hand or onto skin, but I usually only reserve this action for times when I’m at the end of the bottle and I want to use all the Warrior Mist remaining in the bottle.
The small bottle travels well, and I usually take it with me whenever I travel. I also keep a bottle ready in a small hiking kit that I carry with me on the trail. While I may not always need it, nevertheless it is there. I cannot count how often I used it when I’ve least expected to need it. Sprained ankles or swollen fingers heal a lot faster than you might expect, compared to not having Warrior Mist around. It even works well on things like mosquito bites—and helps repel them.
Warrior Mist can be combined effectively with other natural topical products, especially Ancient Minerals Magnesium Oil (see video). I often mix a little Warrior Mist with Magnesium Oil in my palm. This mix gives me all the benefits of Warrior Mist with the added boost of extra magnesium chloride that speeds healing.
WARRIOR MIST BENEFITS
Warrior Mist offers rapid pain relief and many other benefits:
• RAPID, EFFECTIVE PAIN RELIEF – Formulated as a fast-acting pain reliever using only natural ingredients
• LONG LASTING – pain relief last eight hours (or more) per use. This is a natural formula, so you will eventually need to re-apply it. But fewer applications means more time living life pain free.
• SAFE – 100% natural formula. This means that unlike prescription drugs or many over-the-counter medicines, there are no harsh or dangerous side effects.
• RAPID HEALING. Not only effectively relieves pain, but also supports rapid healing at the cellular level. It thereby supports healing at the sources of pain. i.e., helps with the underlying causes of pain.
• REDUCES MUSCLE SORENESS AND TENSION. Another benefit of direct topical application of natural, yet powerful (mostly herbal) ingredients. While this has obvious benefits for athletes,it also helps weekend warriors, or anyone who has muscle soreness due to any reason!
• INCREASES CIRCULATION. Increased circulation is a significant healthy benefit in itself, allowing better oxygenation of tissues, supporting healing, reducing stagnation of blood, and boosting processes of detoxification.
• LESSENS INFLAMMATION. Inflamatory processes can be harmful to the body. Warrior Mist helps reduce inflammation naturally, and thereby lessens free-radical damage from it, for example. This significantly supports your healing process.
• TISSUE REPAIR. When the ingredients in Warrior Mist penetrate tissues, then those tissues can begin the process of healing and repair, and do it faster!
• HEALS SKIN IRRITATIONS. A major added benefit is the healing of “minor” skin irritations, cuts, abrasions, etc. This is because the ingredients in Warrior Mist™ do double duty as superb nutrients for the skin.
• SCAR REDUCTION. Warrior Mist™ can soften scar tissues and stimulate the kind of deep healing that results in smaller scars and improved appearance of scars.
TESTIMONIAL: "Warrior Mist is the only product that I have found which truly relieves the osteoarthritis pain in my knee!! I am amazed by the speed and effectiveness of Warrior Mist. As an older person who has planned and worked to be able to complete my life in my own home, Warrior Mist contributes enormously to my ability to do that! Thank you for this excellent product!" – Amazon customer
WHY IS WARRIOR MIST EFFECTIVE?
Warrior Mist™ is a revolutionary skin, muscle, and joint support formula that uses DMSO, olive oil, coconut oil, and water as base (or carrier) ingredients that transdermally transport the other ingredients directly to the site of the problem where they work together harmoniously and effectively.
Functional ingredients carried to the site of pain include: peppermint oil (the primary source of menthol in the product), magnesium chloride, MSM, lemon oil, and lavender oil. Each of the functional ingredients (and their amounts) were carefully selected for their ability to stop pain, to help the body overcome the causes of pain, to promote healing at the local level, or to work synergistically with the other ingredients. Warrior Mist is 100% all-natural and totally safe!
As a topical analgesic, Warrior Mist conforms to the proposed rules set forth in FDA Monograph 348. The label used on the current Warrior Mist (1 oz spray bottle) meets the requirements set forth in this monograph. Even though there are a number of ingredients in Warrior Mist that can potentially provide temporary pain relief, the FDA monograph only recognizes the ingredient menthol, the major ingredient in peppermint oil, as an allowable active ingredient. According to the monograph, we can only mention menthol as the active ingredient and all other ingredients must be labelled as inactive ingredients.
The truth is that all the ingredients (functional and base/carrier ingredients) add up to a synergistic formula that rapidly relieves pain in a single, easy-to-apply topical product. What more could you ask for?
Dimethyl sulfoxide (DMSO), a by-product of the wood industry, has been in use as a commercial solvent since 1953. Furthermore, in 125 countries throughout the world doctors prescribe it for a variety of issues, including inflammation. DMSO has been used widely as a carrier in topical analgesic formulas. Laboratory studies have shown that DMSO is able to block peripheral nerve C fibers.
Burns, cuts, and sprains have been treated with DMSO. Relief is reported to be almost immediate, lasting up to 6 hours. DMSO reduces inflammation by several mechanisms. It is an antioxidant, a scavenger of the free radicals that gather at the site of injury. Studies have shown DMSO to be one of the safest ingredients known with a toxicity similar to that of water.
DMSO has long been used to promote healing both in animals and humans. Those who have used it for minor cuts and burns report that recovery is speedy. Several studies have documented DMSO use with soft tissue damage, local tissue death, skin ulcers, and burns. Applied topically and repeatedly, DMSO flattens the raised, nodular, lobed liner mass of scar tissue in keloids and acne.
MSM is a naturally occurring nutrient found in normal human diets. In the body DMSO and MSM, which form each other, are indistinguishable in their biochemical effects. They reach a equilibrium distribution between them that is dependent on the local body chemistry, and is independent of which one you start with. The metabolic enhancement mechanism of MSM and DMSO is that of an exceptionally effective oxygen transport system. This system is made particularly effective by the feature that both DMSO and MSM are highly soluble in both oil and water.
MSM makes cell walls permeable, allowing water and nutrients to freely flow into cells and allowing wastes and toxins to properly flow out. The body uses MSM along with Vitamin C to create new healthy cells, and MSM provides the flexible bond between the cells. Without proper levels of MSM, our bodies are unable to build healthy cells, and this leads to problems such as lost flexibility, scar tissue, wrinkles, varicose veins, hardened arteries, damaged lung tissues, dry cracking skin, digestive disorders, joint problems, and inability to defend against allergic reactions to food, animals and plants.
The applications of MSM include pain control (analgesic), inflammation control, dilation of blood vessels, increased blood flow, reduced muscle spasm, altering the crosslinking process in collagen (e.g., reducing scar tissue,) anti-parasitic effects (particularly against Giardia), and immune normalizing effects. MSM has a unique ability to pass through cellular membranes (including skin).
The primary constituent of peppermint oil is menthol, which causes a physical reaction when inhaled or applied to the skin. Menthol produces an immediate and pronounced sensation of coolness that effects the body quite noticeably, and creates a “warming effect” as blood flows into the area of application.
Peppermint oil can be used externally for providing relief from pain. Peppermint oil increases your immunity. It also improves blood circulation. Additional of the uses of peppermint oil include:acne, asthma, colds, cramps, dermatitis, exhaustion, influenza, headache, insect bites, mental fatigue, migraine, nausea, nerve pain, neuralgia, poor circulation, and respiratory disorders.
Lavender oil helps in treating migraines, headaches, anxiety, depression, nervous tension and emotional stress. The refreshing aroma removes nervous exhaustion and restlessness and increases mental activity. Because it induces sleep, it is often recommended for insomnia. Lavender oil is also an excellent remedy for various types of pains including those caused by sore muscles, tense muscles, muscular aches, rheumatism, sprains, backache,and lumbago. A regular massage with lavender oil can provide relief from pain in the joints.
Lavender oil is also good for improving blood circulation in the body. The health benefits of lavender oil for the skin can be attributed to its antiseptic and antifungal properties. It is used to treat various skin conditions, including acne, wrinkles, psoriasis, and other inflammatory conditions. It heals wounds, cuts, burns, and sunburns rapidly because it aids in the formation of scar tissues. It is also effective against insect bites. The oil also repels mosquitoes and moths.
Lemon oil is powerfully astringent and antiseptic. Lemon oil is detoxifying and is therefore good for blemishes associated with oily skin. Lemon oil is a powerful antioxidant and is a tonic for supporting the nervous and sympathetic nervous system. It’s been long known that lemon oil is anti-infective, antibacterial (especially with spores), and antiviral. It can function as a disinfectant and exerts vitamin P-like action for improving microcirculation, promotes white blood cell formation, and improves immune function. It has also been widely used in skin care to cleanse skin and reduce wrinkles.
Magnesium chloride applied to the skin is an effective means for increasing magnesium levels in the body, and is particularly useful for relieving sore muscles and joints, and reducing pain related to functional magnesium deficiency. It is also proven for use in helping to calm “nerves” and reduce systemic bodily stress. Because the magnesium targets muscle tissues, it is thereby especially useful for replenishing depleted soft tissues and helping restore proper function.
Magnesium is necessary for the production of energy in the body. When the body receives adequate amounts of magnesium, it can produce the levels of energy required to sustain the body and enable it to thrive. Magnesium chloride is proven for use in a variety of general applications, including bruises, cramps, muscle tension, and migraine headaches.
Used as a base and mixed with other essential oils, olive oil makes a wonderful oil for skin health. In fact, it has been touted as one of the oldest healing and beauty techniques. A biblical reference from about 493 BCE documents the daily massage with olive oil and other oils as a part of the beauty regimen.
Coconut oil is a superb skin lotion because it both nourishes skin and is naturally anti-bacterial, antiviral, and antifungal due to its high content of medium chain triglycerides
DIRECTIONS: Shake bottle before applying. Wash hands before and after use. Apply in a thin layer to a clean, dry, and lotion-free area needing support. Shave thick hair that may prevent absorption by the skin. Gently massage the area of application to assist absorption. Reapply as needed 3–4 times daily. Contains DMSO, a known solvent. Use on people or pets at your own discretion.
USES: Warrior Mist™ is an all-natural skin, muscle, and joint support formula.
WARNINGS: For external use only. May cause temporary (up to 45 minutes) skin irritation, heating, or flushing upon use. Discontinue use if temporary skin conditions persist. Do not use on wounds or severely damaged skin. Do not bandage tightly. Avoid contact with eyes. Flush eyes with cool water if exposed. Do not use if allergic to any ingredients. Stop use and visit a health care professional if reason for use continues for more than one week. If swallowed get medical help or call a Poison Control Center. Consult a health care professional before use if pregnant.
Warrior Mist topical formula is highly effective for pain relief. A major advantage is that it is a natural formula (available without a prescription) and can safely be re-applied whenever necessary. Another benefit is that it lacks the side effects common to prescription pain medications.
Try Warrior Mist for yourself. If you’re like me, you will want to keep a bottle or two ready for the aches and pains of daily life. Use it as often as you need it. Be a warrior!
Omega-3 essential fatty acids (EFA) are critically important for health. That is the reason we at HPDI include them in our foundational supplements system in the form of our Essential Fats Plus E formula. Essential Fats Plus E provides a balanced ratio of 4:1 omega-3 EPA to omega-6 GLA fatty acids proven to optimally support health.
As important as Omega-3 fats are in good health, various studies conclude they are of little value. In order to help clarity the fallacies found in such studies, this month we re-print the recent article “Omega 3 Fatty Acids and Cardiovascular Disease” from the Orthomolecular News Service (OMNS).
Essential fats including Omega-3 and Omega-6 are so important to health that we consider them as foundational or “core” to basic nutrition as multivitamins, antioxidants/vitamin C formulas, and high-RNA superfoods, like Rejuvenate! Plus.
Many of today’s health problems relate to deficiencies in Omega-3 essential fatty acids rather than overabundance of it. It makes sense for everyone to supplement their diets with at least a minimum amount of essential fats. This is addition to consuming foods high in Omega-3 (and Omega-6) essential fats, including leafy greens, nuts, seeds, and seed oils. Also, small amounts of wild-caught fish from clean waters. Preferably these fish would come from low on the food chain, such as sardines, herring, or young mackerel, for example.
In December 2107, my father Hank Liers, PhD, wrote “The Truth about Essential Fatty Acids.” In his article, he delves into detail about why essential fatty acids are critical for health.
The diagram below from Dr. Hank’s article shows in detail the pathways for the production and use of fatty acids in the body. In the figure the metabolic pathways (running left to right) for four fatty acids types are shown (top – Omega-3, second – Omega-6, third – Omega-9, bottom – Omega-7). Notice that only the omega-3 and omega-6 oils are considered to be essential fatty acids because they cannot be made in the body. This means they must come from food.
Furthermore, an additional diagram from Dr. Hank’s article shown below provides details of the omega-6 and omega-3 pathways. Pathway specifics indicate key eicosanoids (series 1 prostaglandins [anti-inflammatory], series 2 prostaglandins [pro-inflammatory], and series 3 prostaglandins [anti-inflammatory]), oil sources, and important nutrient cofactors that are needed for the reactions to take place.
In particular, Dr. Hank discusses how superior benefits to health result from a balanced 4:1 ratio between Omega-3 eicosapentanoic acid (EPA) fatty acids and Omega-6 gamma linoleic acid (GLA).
Below we list some of the functions and benefits obtained when by diet or supplementation the correct ratios and amounts of essential fatty acids are consumed.
• Regulate steroid production and hormone synthesis • Regulate pressure in the eyes, joints, and blood vessels • Regulate response to pain, inflammation, and swelling • Mediate Immune Response • Regulate bodily secretions and their viscosity • Dilate or constrict blood vessels • Regulate smooth muscle and autonomic reflexes • Are primary constituents of cellular membranes • Regulate the rate at which cells divide • Necessary for the transport of oxygen from the red blood cells to tissues • Necessary for proper kidney function and fluid balance • Prevent red blood cells from clumping together • Regulate nerve transmission
Dr. Hank also discusses the fallacy of thinking that supplemental Omega-3 fats alone are sufficient to produce health. That is, despite the relative lack of Omega-3 essential fats and the prevalence of Omega-6 fats in modern diets, it is nevertheless the forms (EPA and GLA)—and the critical 4:1 ratio between them—that makes the difference in how they act synergistically for health. The result of Hank’s scientific understanding of essential fatty acids has resulted in his formulation of a balanced EFA product, Essential Fats Plus E.
Orthomolecular Medicine News Service Article “Omega 3 Fatty Acids and Cardiovascular Disease”
Regarding the Orthomolecular Medicine News Service article “Omega 3 Fatty Acids and Cardiovascular Disease” (republished below) rebutting the “Cochrane Database of Systematic Reviews” which relies on so-called “Evidence Based Medicine” (EBM) to distort truth on Omega-3 essential fatty acids, the fact that Omega-3 fats are under such false attack represents a huge disservice to the public.
While essential fatty acids may not generate profits for corporations—and in fact may lead to improved health outcomes that threaten the use of chemicals and drugs—essential fats nevertheless remain foundational for health.
Above we have shown the important reasons Omega-3 fats and other essential fatty acids are scientifically termed “essential.” And why people continue taking essential fats, and giving them to their families and children, for supporting health and well-being. Primary among these reasons is that you cannot be healthy without them. Hence, they are essential. Why believe anyone who says otherwise?
The bottom line: Omega-3 essential fatty acids are critical for health. Supplementing the diet with them is a good idea for nearly everyone. This is especially true because typical diets are proven to be most deficient in Omega-3 among essential fats.
Below we re-print in full the recent article “Omega 3 Fatty Acids and Cardiovascular Disease” from the Orthomolecular News Service (OMNS) for the benefit of our HPDI blog readers. ~
FOR IMMEDIATE RELEASE
Orthomolecular Medicine News Service, Aug 6, 2018
Omega-3 Fatty Acids and Cardiovascular Disease
Commentary by Damien Downing, MBBS, MSB and Robert G. Smith, PhD
The Cochrane Database of Systematic Reviews has just updated its own review: Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease . Here’s our take on it.
Michael Pollan, the brilliant food writer, reckoned you could sum up what to do about nutrition and diets in 7 words; “Eat food, not too much, mostly plants.” That sums up both what’s best for humans and what’s best for the planet.
We reckon you can sum up what’s wrong with evidence-based medicine (EBM) in 10 words; “Evidence is a waste of data; systematic reviews are palimpsests.” You can use that as a knife to quickly dissect this study.
There are many things wrong with this review. Somebody’s PR department has spun the review’s “no clear evidence of benefit” into “evidence of no benefit” – absence of evidence becoming evidence of absence. And clearly the media were entirely happy to take that one and run with it.
Systematic reviews are palimpsests
What’s a palimpsest? Back when things got written on vellum, an animal skin, not on paper, you didn’t throw it away; you recycled it and wrote over the original. It was called a palimpsest.
A systematic review gives an opportunity to write over the conclusions of a whole list of papers with your new version of the truth. You do that by the way that you select and exclude them.
For instance there was a meta-analysis (that’s a systematic review with more numbers) in 2005 that concluded that vitamin E supplements significantly increased the risk of death . The way they did that was to rule out any study with less than 10 deaths – when fewer deaths was exactly the outcome they were supposed to be looking for.
The reason they gave for doing that was “because we anticipated that many small trials did not collect mortality data.” We’re not buying it; they used it as a trick to enable them to get the negative result they wanted – to over-write the findings of a long list of original studies.
And here we have authors doing the very same thing in this omega-3 study – and upping the ante slightly. Now the threshold is 50 deaths. Fewer than that and your study is ruled out of the final, supposedly least biased, analysis . . on the grounds that it’s more biased.
We don’t know how they could keep a straight face while saying (our interpretation); “The studies with fewer deaths showed more benefit from omega-3s, so we excluded them.” At least that’s what happened back in 2004 when the first version of this came out.
But this is the 8th update (we think) and they no longer bother to tell you about what they included or excluded in detail, so we can only assume that if they had changed that exclusion they would have told us.
The weird thing is that they are allowed to do it. Nutrition researcher Dr. Steve Hickey has shown that in systematic reviews there is generally control for bias in the included studies, but none for bias in the actual review and its authors.[4,5]
They found not one example of adequate blinding among 100 Cochrane reviews (like this one); they could all be palimpsests. Do we know that they are fake? No, but it doesn’t matter: what we do know is that we can’t trust them. Nor can we trust this Cochrane review. Things haven’t changed since 2004.
Evidence is a waste of data
Evidence is what lawyers and courts use to find someone Guilty or Not Guilty, and we all know how that can go wrong. It’s a binary system: you’re either one or the other. But at least if you’re on trial all the evidence should be about you and whether you did the crime.
In EBM the evidence is all about populations, not about individuals. When a doctor tells you “There’s a 1 in 3 chance this treatment will work” he is required to base that on big studies, or even systematic reviews. You don’t, and you can’t, know what that means for you because very likely you don’t fit the population profile.
As Steve Hickey (again) said, the statistical fallacy underlying all this states that you have one testicle and one ovary – because that’s the population average! The authors of this study update started off with about 2100 papers that looked relevant. They then excluded 90 per cent of them for various reasons – some of them good reasons, some not.
A smarter way to work would be to data-mine them and look for useful information about sub-groups and sub-effects in all the papers. Is there a particular reason omega-3s might work for you and not for others? Perhaps you can’t stand fish, or are allergic to them, and so are deficient in omega-3s.
But the review system doesn’t allow it, it insists on overall conclusions (about populations), and that’s a colossal waste of data. It also confounds the overall finding of the review – it biases it in fact.
Here’s an example: while most subgroups that made it to the final analysis showed a small reduction in risk from taking omega-3s in one form or another (pills, food, whatever), those who got it from supplemented foods, which we understand means stuff like margarine with added omega-3, showed a 4.3-fold death risk increase!
The problem here is that the effects of omega-3 fatty acids cannot be studied alone as if they were a drug. What counts are all the other components of the diet that affect a person’s health.
Processed foods and drinks that contain many unhealthy ingredients can’t be made healthy by adding small doses of vitamins, minerals, and omega-3 fatty acids. In fact, many processed foods that contain small doses of vitamins and other essential nutrients are unhealthy because they contain large doses of sugar, salt, and harmful ingredients such as preservatives, dyes, and other non-food items.
Why lipids are so important
Part of the problem is that lipids are truly complicated, and not many people, patients, doctors or even scientists, understand them well. You need a good understanding of lipid metabolism to appreciate the difference in metabolism and impact between alpha-linolenic acid (ALA, in food such as oily fish) and extracted oils such as EPA and DHA that are only found at high levels in omega-3 supplements.
At these levels they are effectively new to nature; nobody, indeed no mammal, was exposed to really high doses of DHA until we invented fish oil supplements . Miss that fact and you miss the difference between having people eat fresh oily fish or just using omega-3 margarine!
We know from a variety of studies that a diet containing generous portions of green leafy and colorful vegetables and fruits, moderate portions of eggs, fish, and meat, and supplements of adequate doses of essential nutrients (vitamins and minerals) is effective at lowering the risk for cardiovascular disease.
Adequate doses of both omega-3 (in flax oil, walnuts, fish) and omega-6 (in seed oils such as canola, soybean, peanut) fatty acids are essential for health. Although essential, omega-6 fatty acids are thought to contribute to inflammation throughout the body whereas omega-3 fatty acids are anti-inflammatory.
Omega-3 fatty acids are essential for most body organs including the brain but are found in lower levels than omega-6 fatty acids in most vegetables. Risk for cardiovascular disease can be lowered by adequate doses of vitamins C (3,000-10,000mg/d), D (2,000-10,000 IU/d), E (400-1,200 IU/d), and magnesium (300-600 mg/d) in addition to an excellent diet that includes an adequate dose of omega-3 fatty acids.
(Dr. Damien Downing is a specialist physician practicing in London, and President of the British Society for Ecological Medicine. Robert G. Smith is a physiologist and Research Associate Professor at the University of Pennsylvania Perelman School Of Medicine.)
2. Miller ER, Pastor-Barriuso R, Dalal D, et al., (2005) Review Meta-Analysis?: High-Dosage Vitamin E Supplementation May Increase. Annals of Internal Medicine, 142(1), pp.37-46. Available at: http://annals.org/article.aspx?articleid=718049.
4. Hickey S, Noriega LA. Implications and insights for human adaptive mechatronics from developments in algebraic probability theory, IEEE, UK Workshop on Human Adaptive Mechatronics (HAM), Staffs, 15-16 Jan 2009.
6. Cortie CH, Else, PL, (2012) Dietary docosahexaenoic acid (22:6) incorporates into cardiolipin at the expense of linoleic acid (18:2): Analysis and potential implications. International Journal of Molecular Sciences, 13(11): 15447-15463. http://www.mdpi.com/1422-0067/13/11/15447
7. Case HS (2017) Orthomolecular Nutrition for Everyone. Turner Publication Co., Nashville, TN. ISBN-13: 978-1681626574
The peer-reviewed Orthomolecular Medicine News Service is a non-profit and non-commercial informational resource.
Editorial Review Board:
Ilyès Baghli, M.D. (Algeria)
Ian Brighthope, M.D. (Australia)
Prof. Gilbert Henri Crussol (Spain)
Carolyn Dean, M.D., N.D. (USA)
Damien Downing, M.D. (United Kingdom)
Michael Ellis, M.D. (Australia)
Martin P. Gallagher, M.D., D.C. (USA)
Michael J. Gonzalez, N.M.D., D.Sc., Ph.D. (Puerto Rico)
William B. Grant, Ph.D. (USA)
Tonya S. Heyman, M.D. (USA)
Suzanne Humphries, M.D. (USA)
Ron Hunninghake, M.D. (USA)
Michael Janson, M.D. (USA)
Robert E. Jenkins, D.C. (USA)
Bo H. Jonsson, M.D., Ph.D. (Sweden)
Jeffrey J. Kotulski, D.O. (USA)
Peter H. Lauda, M.D. (Austria)
Thomas Levy, M.D., J.D. (USA)
Homer Lim, M.D. (Philippines)
Stuart Lindsey, Pharm.D. (USA)
Victor A. Marcial-Vega, M.D. (Puerto Rico)
Charles C. Mary, Jr., M.D. (USA)
Mignonne Mary, M.D. (USA)
Jun Matsuyama, M.D., Ph.D. (Japan)
Dave McCarthy, M.D. (USA)
Joseph Mercola, D.O. (USA)
Jorge R. Miranda-Massari, Pharm.D. (Puerto Rico)
Karin Munsterhjelm-Ahumada, M.D. (Finland)
Tahar Naili, M.D. (Algeria)
W. Todd Penberthy, Ph.D. (USA)
Dag Viljen Poleszynski, Ph.D. (Norway)
Jeffrey A. Ruterbusch, D.O. (USA)
Gert E. Schuitemaker, Ph.D. (Netherlands)
Thomas L. Taxman, M.D. (USA)
Jagan Nathan Vamanan, M.D. (India)
Garry Vickar, MD (USA)
Ken Walker, M.D. (Canada)
Anne Zauderer, D.C. (USA)
Andrew W. Saul, Ph.D. (USA), Editor-In-Chief
Editor, Japanese Edition: Atsuo Yanagisawa, M.D., Ph.D. (Japan)
Robert G. Smith, Ph.D. (USA), Associate Editor
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Looking for an advanced antioxidant formula? Already using or recommending vitamin C? Curious about cellular Nrf2 activation? Look no further than PRO-C™.
PRO-C™ is among the most effective antioxidant formulas available. It is an HPDI foundational supplement that works most effectively when used with multivitamins, essential fats, and superfoods. However, it is also an excellent standalone formula that can rapidly provide the body with extremely high protection from free radicals.
We ourselves have taken PRO-C daily for many years with excellent results. Our personal experience together with detailed feedback from health professionals and end-users affirms the effectiveness of PRO-C as a super-antioxidant–vitamin C-Nrf2 activator formula.
PRO-C provides 500 mg of buffered vitamin C per capsule (buffered with calcium, magnesium, and zinc) along with grape extract (seed, skin, pulp) and green tea extract (95% polyphenols). In addition, we include a special combination of the “network antioxidants” l-glutathione (reduced), n-acetyl-l-cysteine (NAC), r-lipoic acid, and selenium. Vitamin B2 and Vitamin B6 in coenzyme forms support the enzymatic effectiveness of the “network antioxidants”. The formula works so well because this combination of ingredients leverages the antioxidant power of vitamin C, grape extract, green tea extract, and the other nutrients to act synergistically in order to maximize effectiveness.
FORMULATION HISTORY AND THE SCIENCE BEHIND PRO-C™
What you may not know is the history of the development PRO-C and the scientific knowledge on which Dr. Hank Liers based his formulation of it.
Dr. Hank formulated his first product in 1989. It was a potent antioxidant formula he called PYC-C™ (sounds like “pixie”). PYC-C consisted of a combination of buffered Vitamin C (including magnesium, calcium, and zinc ascorbates) and pycnogenols from pine bark.
By 1997 Dr. Hank had gathered a great deal of new scientific information regarding green tea catechins and the nutrients termed “network antioxidants” by Dr. Lester Packer, director of Packer Lab at University of California, Berkeley. Beyond this information, Dr. Hank studied additional research regarding how various nutrients worked together synergistically. At that point, he was ready to formulate the new, improved PRO-C™ super antioxidant formula.
PRO-C combines the ingredients of PYC-C (now known as OPC-C™) and uses grape pulp, skin, and seed extract with green tea extract (with high polyphenols >95% and EpiGalloCatechinGalate (EGCG) >45%), n-acetyl-l-cysteine (NAC), reduced glutathione (GSH), R-lipoic acid, selenium, and coenzyme Vitamins B2 and B6.
HPDI launched PRO-C™ in late 1997. It rapidly became one of our best-selling products. Our customers raved about how effective it was for them if they felt like they were “coming down with something” (like a cold, flu, virus, infection, etc.). Greater skin elasticity greatly helped pregnant women avoid stretch marks and episiotomies. Today, we highly recommend its use together with our other Foundational Supplements to ensure optimal health and anti-aging effects.
THE PRO-C™ SUPER ANTIOXIDANT FORMULA
PRO-C™ super antioxidant formula is extremely synergistic, especially in so far as it increases the body’s ability to quench free radicals in its aqueous (i.e., water-based) compartments. Because antioxidants may become free radicals themselves after they have done their job, the body has developed an elaborate system for recovery of oxidized antioxidants.
Dr. Lester Packer was the primary researcher investigating the synergistic character of antioxidants. He made this statement in his interview with Dr. Richard Passwater after publication of Packer’s The Antioxidant Miracle (1999):
” [The major theme of] The Antioxidant Miracle is that antioxidants work in a coordinated manner. They interact with one another, and this interaction, which we like to call the antioxidant network, is very important to the overall antioxidant defense that we possess. The key members of the antioxidant network are vitamin E and vitamin C, but there are other participants in this network. These are thiol antioxidants, antioxidants that contain sulfur groups in the body. Glutathione perhaps is the best known of these, but there are other sulfur-containing antioxidants that also are very important.”
Dr. Packer continues:
“This whole antioxidant network works like an orchestra depending on individuals who have, of course, different complements of antioxidants depending upon their nutritional regimens and the individuality of their own body metabolisms. The idea behind having a network of antioxidants is that if one antioxidant happens to be deficient the others can compensate and still keep the antioxidant defense system strong.”
The following diagram shows some of the relationships in the antioxidant network and how they support each other.
Figure 1 – Dr. Packer’s Antioxidant Network
We see, for example, reduced glutathione (GSH) has the ability to reduce oxidized Vitamin C back to its unoxidized state. Vitamin C reduces oxidized Vitamin E back to its unoxidized state, and both reduces glutathione and spares it for other important functions, including detoxification and immune enhancement.
Many polyphenols (e.g., oligomeric proanthocyanidins (OPCs), anthocyanidins and catechins) found in red grape and green tea extracts spare Vitamin C and glutathione in the body, as well as operate as powerful antioxidants, anti-inflammatories, and connective tissue strengtheners.
Grapes provide antioxidant nutrients such as polyphenols, OPCs, anthocyans, and resveratrol.
R-Lipoic Acid (see abstracts below) operates as an antioxidant both in its oxidized and reduced states, reduces the oxidized forms of both Vitamin E and Vitamin C, and and has been shown to enhance glutathione levels. Because several of these substances are able to protect Vitamin E contained in cell membranes, this combination also has a significant beneficial effect on the fat soluble antioxidant status of the body!
The nutrients in PRO-C have been carefully selected and balanced to provide optimal effects, especially as related to free radical protection, detoxification, immune system enhancement, connective tissue strengthening, and reduction of inflammation. PRO-C therefore provides outstanding nutritional support in a wide variety of conditions of poor health, as well as acts to support and maintain a state of health and well-being.
It the last several years the research results on Nrf2 activators have become well known and products developed that take advantage of these nutrients. For details see our blog article Natural Phytochemical Nrf2 Activators for Chemoprevention. Researchers have been studying specifically how enzyme-activating substances such as OPCs and anthocyans activate a transcription factor known as Nrf2 that causes the body to endogenously produce higher levels of a wide variety of protective enzymes including superoxide dismutase (SOD), catalase, and glutathione peroxidase.
Although we did not know about Nrf2 activators in 1997 when we formulated PRO-C, we have subsequently learned that four of the ingredients in the formula have powerful Nrf2 activity. These include grape seed extract, green tea extract, NAC, and r-lipoic acid. With this knowledge, we now understand that PRO-C provides both powerful external antioxidants (with extremely high ORAC5.0 values) that support redox cycles within the body, but also provides ingredients that allow the body to endogenously produce powerful protective enzymes for even greater free-radical protection and health.
PRO-C™ ANTIOXIDANT FORMULA INGREDIENTS
PRO-C contains buffered vitamin C (in the form of powdered calcium, magnesium, and zinc ascorbates), high-potency grape extract (from grape pulp, skins, and seeds), green tea extract (with>95% polyphenols and >45% EGCG), reduced glutathione, N-Acetyl-L-Cysteine (NAC), R-lipoic acid, coenzyme forms of vitamin B2 (R5P) and vitamin B6 (P5P), and selenium.
Below we will discuss each ingredient and show some of the research that confirms its effectiveness.
Vitamin C typically is called l-ascorbic acid or ascorbate and is an essential nutrient for humans and other animal species. The term “vitamin C” refers to a number of vitamins that have vitamin C activity in animals, including ascorbic acid and its salts (e.g., magnesium ascorbate, calcium ascorbate, sodium ascorbate, etc.), and some oxidized forms such as dehydroascorbate and semidehydroascorbate.
Vitamin C is known to perform many critical functions within the body involving detoxification, tissue building, immune enhancement, pain control, and controlling or killing pathogenic organisms. It is also known to be helpful for wound and bone healing, healthy skin and eyes, fighting infections, stress control, toxic exposure, and repairing damaged tissue of all types. For much more information on the many benefits of Vitamin C see our blog article Vitamin C – An Amazing Nutrient.
Below are two abstracts that show some of the beneficial effects of Vitamin C when used with other network antioxidants:
ABSTRACT 1: Exhaustive physical exercise causes oxidation of glutathione status in blood: prevention by antioxidant administration.
Sastre J, Asensi M, Gasco E, Pallardo FV, Ferrero JA, Furukawa T, Vina J
In: Am J Physiol (1992 Nov) 263(5 Pt 2):R992-5
We have studied the effect of exhaustive concentric physical exercise on glutathione redox status and the possible relationship between blood glutathione oxidation and blood lactate and pyruvate levels. Levels of oxidized glutathione (GSSG) in blood increase after exhaustive concentric physical exercise in trained humans. GSSG levels were 72% higher immediately after exercise than at rest. They returned to normal values 1 h after exercise. Blood reduced glutathione (GSH) levels did not change significantly after the exercise. We have found a linear relationship between GSSG-to-GSH and lactate-to-pyruvate ratios in human blood before, during, and after exhaustive exercise. In rats, physical exercise also caused an increase in blood GSSG levels that were 200% higher after physical exercise than at rest. GSH levels did not change significantly. Thus, both in rats and humans, exhaustive physical exercise causes a change in glutathione redox status in blood. We have also found that antioxidant administration, i.e., oral vitamin C, N-acetyl-L- cysteine, or glutathione, is effective in preventing oxidation of the blood glutathione pool after physical exercise in rats.
The effect of glutathione and vitamins A, C, and E on acute skin flap survival.
Hayden RE, Paniello RC, Yeung CS, Bello SL, Dawson SM
In: Laryngoscope (1987 Oct) 97(10):1176-9
Vitamins A, C, and E act as antioxidants and as free radical scavengers in biological systems. Glutathione is involved in several reactions in vitamin metabolism and also plays an important role in cell membrane protection against lipid peroxidation by free radicals. We sought to use these natural defense mechanisms against oxygen free radicals formed during reperfusion of ischemic skin flaps. An acute axial random skin flap model was utilized in the rat. Vitamins or glutathione were administered by oral gastric tube or intravenously in the perioperative period, and survival of the flap was measured at 1 week. Glutathione, beta-carotene, ascorbic acid and alpha-D- tocopherol showed mean flap survival of 84% to 89%, each of which was significantly improved over saline controls (67% p less than .0005). The mechanisms and biochemistry of these vitamins, and their interactions with other vitamins and with glutathione, are discussed, along with clinical implications of free radical scavenging and skin flap survival.
Grape extract (seeds, skin, pulp) contain highly bioavailable bioflavonoid complexes that in research studies have been shown to have powerful antioxidant capability. The Oligomeric Proanthocyanidins (OPCs) in grape seed extract are able to strengthen collagen fibers in aging or damaged connective tissue and can act as a preventative against connective tissue degradation.
Some research indicates that anthocyans, which are found in extracts of grape skin and stems (but not in grape seed extract), can reduce oxidized glutathione while at the same time become reduced themselves. In addition, extracts of grape skin and stems (but not those of grape seed extract) contain a material called trans-resveratrol that has been shown to have chemopreventive effects.
ABSTRACT 3: Protective effects of grape seed proanthocyanidins and selected antioxidants against TPA-induced hepatic and brain lipid peroxidation and DNA fragmentation, and peritoneal macrophage activation in mice. Bagchi D, Garg A, Krohn RL, Bagchi M, Bagchi DJ, Balmoori J, Stohs SJ
In: Gen Pharmacol (1998 May) 30(5):771-6
1. The comparative protective abilities of a grape seed proanthocyanidin extract (GSPE) (25-100 mg/kg), vitamin C (100 mg/kg), vitamin E succinate (VES) (100 mg/kg) and beta-carotene (50 mg/kg) on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced lipid peroxidation and DNA fragmentation in the hepatic and brain tissues, as well as production of reactive oxygen species by peritoneal macrophages, were assessed. 2. Treatment of mice with GSPE (100 mg/kg), vitamin C, VES and beta-carotene decreased TPA-induced production of reactive oxygen species, as evidenced by decreases in the chemiluminescence response in peritoneal macrophages by approximately 70%, 18%, 47% and 16%, respectively, and cytochrome c reduction by approximately 65%, 15%, 37% and 19%, respectively, compared with controls. 3. GSPE, vitamin C, VES and beta-carotene decreased TPA-induced DNA fragmentation by approximately 47%, 10%, 30% and 11%, respectively, in the hepatic tissues, and 50%, 14%, 31% and 11%, respectively, in the brain tissues, at the doses that were used. Similar results were observed with respect to lipid peroxidation in hepatic mitochondria and microsomes and in brain homogenates. 4. GSPE exhibited a dose-dependent inhibition of TPA- induced lipid peroxidation and DNA fragmentation in liver and brain, as well as a dose-dependent inhibition of TPA-induced reactive oxygen species production in peritoneal macrophages. 5. GSPE and other antioxidants provided significant protection against TPA-induced oxidative damage, with GSPE providing better protection than did other antioxidants at the doses that were employed.
ABSTRACT 4: Clinical and capillaroscopic evaluation of chronic uncomplicated venous insufficiency with procyanidins extracted from vitis vinifera
Costantini A, De Bernardi T, Gotti A
In: Minerva Cardioangiol (1999 Jan-Feb) 47(1-2):39-46
BACKGROUND: The pharmacological treatment of non-complicated chronic venous insufficiency is a current and well-debated topic. The introduction of new products with action on the venous system, improved knowledge on the physiopathology of venous insufficiency and the possibility provided by new analytical instruments, have given new impulse to the consolidation of the clinical value of phlebotonics in this indication. METHODS: In light of this, 24 patients with non-complicated chronic venous insufficiency were treated with oral administration of Oligomeric Proanthocyanidins (Pycnogenols-OPC) 100 mg/day. To evaluate the therapeutic efficacy of the treatment, an instrumental evaluation by optical probe capillaroscope was employed in addition to the traditional subjective clinical parameters: swelling, itching, heaviness and pain. The videocapillaroscope examination was performed at the lower third of the leg and the first toe. Edema in the capillaroscopic field, the number of observable capillaries and the capillary dilatation were the parameter chosen to evaluate the efficacy of treatment. All patients completed the study with no reports of adverse events during the period of observation. RESULTS: The results obtained show a positive clinical response (improved or absent symptoms) in over 80% of patients, with significant improvement of symptoms already evident after the first 10 days of treatment. The mechanism of action of the OPCs explains the rapid reduction of the swelling of the lower limbs and correlated with this are the other evaluable symptoms: heaviness and itching. Particularly striking results were observed for itching and pain which completely disappeared during the course of therapy in 80% and 53% of the patients respectively. Noteworthy is the good correlation between the clinical and instrumental data, with improvement in a total of 70% of patients. CONCLUSIONS: The results obtained in the course of this clinical experience, with evident improvement already during the first weeks of treatment, the absence of adverse events added to the benefit of a once-a-day administration, justify the use of OPC in the treatment of non-complicated chronic venous insufficiency.
Nuclear factor erythroid 2-related factor 2 (Nrf2) is an important transcription factor that regulates antioxidant response element (ARE)-driven phase II detoxification enzymes. In this study, induction of phase II enzymes via Nrf2/ARE activation in the cytoprotective effect of crude polyphenol extract (CPE), oligomeric procyanidin fraction (OPF), and polymeric procyanidin fraction (PPF) from defatted grape seeds in HepG2 cells was evaluated. Among these treatments, the treatment with PPF significantly increased Nrf2 protein expression in the nuclear fraction. Treating the samples increased heme oxygenase-1 (HO-1) and NAD(P)H:quinone oxidoreductase 1 (NQO1) protein expression in a dose-dependent manner, and PPF significantly increased the levels of phase II enzymes. Cellular generation of reactive oxygen species (ROS) were effectively reduced by PPF. These results suggest that pretreatment with PPF shows a cytoprotective effect by inhibiting ROS production and inducing HO-1 and NQO1 expression via Nrf2 activation in HepG2 cells.
GREEN TEA EXTRACT
Green tea extract is obtained from the unfermented leaves of Camellia sinensis for which numerous biological activities have been reported including: antimutagenic, antibacterial, hypocholesterolemic, antioxidant, and protective against tumorigenesis. Below we have selected a few of the many abstracts we have on file showing the benefit of green tea extract.
Green tea leaves are high in antioxidant polyphenols and catechins.
ABSTRACT 6: Enhancement of antioxidant and phase II enzymes by oral feeding of green tea polyphenols in drinking water to SKH-1 hairless mice: possible role in cancer chemoprevention.
Khan SG, Katiyar SK, Agarwal R, Mukhtar H
In: Cancer Res (1992 Jul 15) 52(14):4050-2
Following the oral feeding of a polyphenolic fraction isolated from green tea (GTP) in drinking water, an increase in the activities of antioxidant and phase II enzymes in skin, small bowel, liver, and lung of female SKH-1 hairless mice was observed. GTP feeding (0.2%, w/v) to mice for 30 days significantly increased the activities of glutathione peroxidase, catalase, and quinone reductase in small bowel, liver, and lungs, and glutathione S-transferase in small bowel and liver. GTP feeding to mice also resulted in considerable enhancement of glutathione reductase activity in liver. In general, the increase in antioxidant and phase II enzyme activities was more pronounced in lung and small bowel as compared to liver and skin. The significance of these results can be implicated in relation to the cancer chemopreventive effects of GTP against the induction of tumors in various target organs.
ABSTRACT 7: INHIBITORY EFFECT OF SIX GREEN TEA CATECHINS AND CAFFEINE ON THE GROWTH OF FOUR SELECTED HUMAN TUMOR CELL LINES. In: Anticancer Drugs (1996 Jun) 7(4):461-8
Institutional address: Department of Pharmacology and Toxicology College of Pharmacy University of Arizona Tucson 85721 USA.
Green tea is an aqueous infusion of dried unfermented leaves of Camellia sinensis (family Theaceae) from which numerous biological activities have been reported including antimutagenic, antibacterial, hypocholesterolemic, antioxidant, antitumor and cancer preventive activities. From the aqueous-alcoholic extract of green tea leaves, six compounds (+)-gallocatechin (GC), (-)-epicatechin (EC), (-)- epigallocatechin (EGC), (-)-epicatechin gallate (ECG), (-)- epigallocatechin gallate (EGCG) and caffeine, were isolated and purified. Together with (+)-catechin, these compounds were tested against each of four human tumor cells lines (MCF-7 breast carcinoma, HT-29 colon carcinoma, A-427 lung carcinoma and UACC-375 melanoma). The three most potent green tea components against all four tumor cell lines were EGCG, GC and EGC. EGCG was the most potent of the seven green tea components against three out of the four cell lines (i.e. MCF-7 breast cancer, HT-29 colon cancer and UACC-375 melanoma). On the basis of these extensive in vitro studies, it would be of considerable interest to evaluate all three of these components in comparative preclinical in vivo animal tumor model systems before final decisions are made concerning which of these potential chemopreventive drugs should be taken into broad clinical trials.
GLUTATHIONE AND N-ACETYL-L-CYSTEINE (NAC)
Glutathione and NAC (a major precursor of glutathione) both provide important protection against toxins and free radicals, and can strengthen the immune system. Glutathione is considered to be one of the most important protective substances in the human body with almost 60% of liver detoxification accounted for by this key substance. In addition, glutathione is one of the most potent anti-viral substances known.
Some research has indicated that glutathione may not be able to enter easily into certain types of cells, but NAC is able to enter these cells and be converted into glutathione once inside the cell. Thus, the combination of glutathione and NAC appear to be more potent than either alone.
ABSTRACT 8 GSH rescue by N-acetylcysteine.
Ruffmann R Wendel A
In: Klin Wochenschr (1991 Nov 15) 69(18):857-62
Reduced glutathione (GSH) is the main intracellular low molecular weight thiol. GSH acts as a nucleophilic scavenger and as an enzyme-catalyzed antioxidant in the event of electrophilic/oxidative tissue injury. Therefore, GSH has a major role as a protector of biological structures and functions. GSH depletion has been recognized as a hazardous condition during paracetamol intoxication. Conversely, GSH rescue, meaning recovery of the protective potential of GSH by early administration of N-acetylcysteine (NAC), has been found to be life-saving. Lack of GSH and electrophilic/oxidative injury have been identified among the causes of the adult respiratory distress syndrome (ARDS), idiopathic pulmonary fibrosis (IPF), and the acquired immunodeficiency syndrome (AIDS). Experimental and early clinical data (in ARDS) point to the role of NAC in the treatment of these conditions. Recently, orally given NAC has been shown to enhance the levels of GSH in the liver, in plasma, and notably in the bronchoalveolar lavage fluid. Rescue of GSH through NAC needs to be appreciated as an independent treatment modality for an array of different disease, all of which have one feature in common: pathogenetically relevant loss of GSH.
ABSTRACT 9 Cysteine and glutathione concentrations in plasma and bronchoalveolar lavage fluid after treatment with N-acetylcysteine.
Bridgeman MM Marsden M MacNee W Flenley DC Ryle AP
In: Thorax (1991 Jan) 46(1):39-42
N-acetylcysteine (600 mg/day) was given to patients by mouth for five days before bronchoscopy and bronchoalveolar lavage to determine whether N-acetylcysteine could increase the concentrations of the antioxidant reduced glutathione in plasma and bronchoalveolar lavage fluid. Bronchoalveolar lavage was performed 1-3 hours (group 2, n = 9) and 16-20 hours (group 3, n = 10) after the last dose of N-acetylcysteine and the values were compared with those in a control group receiving no N-acetylcysteine (group 1, n = 8). N-Acetylcysteine was not detected in plasma or lavage fluid. Plasma concentrations of cysteine, the main metabolite of N-acetylcysteine and a precursor of reduced glutathione, were greater in the groups receiving treatment (groups 2 and 3) than in group 1. Cysteine concentrations in lavage fluid were similar in the three groups. Concentrations of reduced glutathione were greater in both plasma and lavage fluid in group 2 than in group 1. These data suggest that N-acetylcysteine given by mouth is rapidly deacetylated to cysteine, with resulting increases in the concentrations of cysteine in plasma and of reduced glutathione in plasma and the airways, which thus temporarily increase the antioxidant capacity of the lung.
R-LIPOIC ACID / ALPHA-LIPOIC ACID
R-Lipoic Acid is normally made at low levels in the human body, where it functions primarily as an important metabolic nutrient in the conversion of pyruvic acid into acetyl coenzyme A. As such, it plays a crucial role in the metabolism of both fats and carbohydrates into energy. In addition, r-lipoic acid functions as an extremely powerful antioxidant capable of trapping many different types of free radicals in the body.
Because it is both water and fat soluble, lipoic acid is able to operate in a broader range of body tissues than most other antioxidants. Its small size allows lipoic acid to enter areas of the body not easily accessible to many other substances; this allows lipoic acid, for example, to enter the cell nucleus and prevent free-radical damage to DNA.
Because it is such a powerful antioxidant and can easily function as such in both a reduced and oxidized state, lipoic acid is able to protect other important antioxidants such as glutathione, Vitamin E, and Vitamin C. R-lipoic acid is also able to chelate heavy metals such as lead, cadmium, mercury, free iron, and free copper out of the body.
Below we provide relevant scientific abstracts from our database regarding R-Lipoic acid.
ABSTRACT 10: Alpha-Lipoic acid as a biological antioxidant.
Packer L Witt EH Tritschler HJ
In: Free Radic Biol Med (1995 Aug) 19(2):227-50
alpha-Lipoic acid, which plays an essential role in mitochondrial dehydrogenase reactions, has recently gained considerable attention as an antioxidant. Lipoate, or its reduced form, dihydrolipoate, reacts with reactive oxygen species such as superoxide radicals, hydroxyl radicals, hypochlorous acid, peroxyl radicals, and singlet oxygen. It also protects membranes by interacting with vitamin C and glutathione, which may in turn recycle vitamin E. In addition to its antioxidant activities, dihydrolipoate may exert prooxidant actions through reduction of iron. alpha-Lipoic acid administration has been shown to be beneficial in a number of oxidative stress models such as ischemia-reperfusion injury, diabetes (both alpha-lipoic acid and dihydrolipoic acid exhibit hydrophobic binding to proteins such as albumin, which can prevent glycation reactions), cataract formation, HIV activation, neurodegeneration, and radiation injury. Furthermore, lipoate can function as a redox regulator of proteins such as myoglobin, prolactin, thioredoxin and NF-kappa B transcription factor. We review the properties of lipoate in terms of (1) reactions with reactive oxygen species; (2) interactions with other antioxidants; (3) beneficial effects in oxidative stress models or clinical conditions.
Alpha-lipoic acid (α-LA) is an important antioxidant that is capable of regenerating other antioxidants, such as glutathione (GSH). However, the underlying molecular mechanism by which α-LA regenerates GSH remains poorly understood. The current study aimed to investigate whether α-LA regenerates GSH by activation of Nrf2 to alleviate cadmium-induced cytotoxicity in HepG2 cells. In the present study, we found that cadmium induced cell death by depletion of GSH through inactivation of Nrf2. Addition of α-LA to cadmium-treated cells reactivated Nrf2 and regenerated GSH through elevating the Nrf2-downstream genes γ-glutamate-cysteine ligase (γ-GCL) and GR, both of which are key enzymes for GSH synthesis. However, blocking Nrf2 with brusatol in the cells co-treated with α-LA and cadmium reduced the mRNA and the protein levels of γ-GCL and GR, thus suppressed GSH regeneration by α-LA. Our results indicated that α-LA activated Nrf2 signaling pathway, which upregulated the transcription of the enzymes for GSH synthesis and therefore GSH contents to alleviate cadmium-induced cytotoxicity in HepG2 cells.
Selenium has been shown by clinical research to be a key mineral in the body’s defenses against free radicals and has been shown to be a major factor in reducing the symptoms of HIV infections and in the prevention of tumors. Selenium is used in conjunction with glutathione to form the powerful enzyme glutathione peroxidase that is responsible for detoxification of peroxides formed during the process of aerobic metabolism in humans and other animals.
ABSTRACT 12 Serum selenium concentrations in rheumatoid arthritis.
In: Ann Rheum Dis (1991 Jun) 50(6):376-8
O’Dell JR, Lemley-Gillespie S, Palmer WR, Weaver AL, Moore GF, Klassen LW
Selenium is a trace element and an essential part of the enzyme glutathione peroxidase, which protects cells from oxidative damage. Selenium has been shown to have antiproliferative, anti-inflammatory, antiviral, and immune altering effects. Serum selenium concentrations in 101 patients with seropositive rheumatoid arthritis were found to be significantly lower than those in 29 normal, healthy controls (mean (SD) 148 (42) v 160 (25) micrograms/l) and also lower than those in eight patients with fibrositis (148 (42) v 166 (25) micrograms/l). It is speculated that serum selenium concentrations may modulate the effect of viral or other infections in subjects with the appropriate genetic background and in this way enhance the development or progression of rheumatoid arthritis.
ABSTRACT 13 Studies on selenium in top athletes.
Dragan I, Ploesteanu E, Cristea E, Mohora M, Dinu V, Troescu VS
In: Physiologie (1988 Oct-Dec) 25(4):187-90
The authors performed a controlled trial in 18 top athletes (9 weight lifters and 9 rowers, girls) in order to make evident some chronic and acute effects (antioxidant) of selenium. Nonprotein–SH (essential glutathione), lipid peroxides (MDA-malondialdehyde), glucose-6-phosphate dehydrogenases (G-6-PDH) and fructose-1,6- diphosphate aldolase in serum, have been recorded initially on basal conditions, after 3 weeks of treatment (100 micrograms/day selenium or placebo) and again after 3 weeks of treatment, also on basal conditions, when crossing over the groups (between a free interval of 10 days). In another trial we registered these parameters on basal conditions and after two hours of hard training accompanied by a per oral administration of 150 micrograms selenium (respectively placebo). The results show significant changes under selenium treatment of the peroxides, G-6-PDH and light changes, not significant of the nonprotein–SH, changes which could suggest an antioxidant effect of this element.
VITAMINS B2 and B6 IN COENZYME FORMS
Vitamin B2 as coenzyme riboflavin-5-phosphate is a key vitamin that supports the regeneration of glutathione (via glutathione reductase). Vitamin B6 as coenzyme pyridoxal-5-phosphate is a key vitamin that supports the ability of glutathione to combine with toxic substances (via glutathione transferase) in the process of eliminating them from the body. They are especially effective in their coenzyme forms which allows them to be directly utilized by the body starting in the intestinal tract.
MAGNESIUM, CALCIUM, AND ZINC
Magnesium, zinc, and calcium synergistically work with (and enhance the effects of) the other ingredients in PRO-C. Minerals are especially needed as active components of enzymes that drive metabolic activity. For example, magnesium is required in the functioning of more than 325 types of enzymes.
PRO-C™ SUPER ANTIOXIDANT FORMULA BENEFITS
HIGHLY EFFECTIVE VITAMIN C FORMULA PLUS ANTIOXIDANTS. A complete vitamin C formula, a powerful antioxidant Formula, and Nrf2 activator combined in a single advanced supplement!
POWERFUL, SYNERGISTIC FREE-RADICAL QUENCHING FORMULA. PRO-C™ components work together to quench free radicals in your body. Vitamin C enables grape seed extract to function more effectively, and conversely grape seed extract potentiates vitamin C. Green tea extract boosts ORAC (Oxygen Radical Absorbance Capacity) value.
PROVIDES SIGNIFICANT AMOUNTS OF POWERFUL NRF2 ACTIVATORS (from Grape Extract, Green Tea Extract, NAC, and R-Lipoic Acid) that stimulate the production of the body’s own protective antioxidants including superoxide dismutase, catalase, glutathione peroxidase, and heme oxygenase.
SUPERIOR, BUFFERED (NON-ACIDIC) FORM OF VITAMIN C. Mineral Ascorbates never acidify your body, keeping you pH balanced. Staying alkaline is an important element in maintaining a healthy body.
RAPID ASSIMILATION. Capsule form ensures rapid uptake and assimilation in the body. You may also empty capsule contents into water, food, or directly Into mouth, if desired. Good, mildly tart taste!
COMPOSITION OF PRO-C™ SUPER ANTIOXIDANT FORMULA
One (1) vegetarian capsule of PRO-C provides the following percentages of the Daily Value:
% Daily Value
Vitamin C (from mineral ascorbates)
BioVin® Grape Extract
Green Tea Extract
Calcium (from calcium ascorbate)
Magnesium (from magnesium ascorbate)
Zinc (from zinc ascorbate)
Vitamin B2 (from riboflavin-5′-phosphate)
Vitamin B6 (from pyridoxal-5′-phosphate)
Selenium (from l-selenomethionine)
* No established Daily Value
DIRECTIONS: As a dietary supplement take 1–3 capsules or more daily in divided doses (i.e., spread out over the day), or as recommended by a health care professional. It initially may be useful to take up to 6 capsules per day in divided doses for one week. The contents of the capsule may be emptied into juice or food, as needed.
INGREDIENTS: PRO-C™ SUPER ANTIOXIDANT FORMULA contains only the highest-quality USP grade magnesium ascorbate, USP grade calcium ascorbate, BioVin® grape extract (greater than 75% polyphenols, 93% OPC, greater than 3.5% anthocyanidins from grape pulp, skins, and seeds, and a small amount of trans resveratrol), green tea extract (95% min. polyphenols and 45% min. EGCG), l-glutathione (reduced), USP grade n-acetyl-l-cysteine, USP grade zinc ascorbate, r-(+)-lipoic acid, riboflavin-5′-phosphate, pyridoxal-5′-phosphate, l-selenomethionine, the smallest amounts of microcrystalline cellulose and silica in a vegetarian capsule.
PRO-C™ does not contain wheat, rye, oats, corn antigen, barley, gluten, soy, egg, dairy, yeast, sugar, sulfates, phosphates (other than coenzyme forms), fats, chlorides, GMOs, wax, preservatives, colorings, or artificial flavorings.
Looking for a natural energy boost? Or a super-power-up, pick-me-up drink? Look no further than Rejuvenate! Lemonade. Rejuvenate! Lemonade offers all the deliciousness of fresh lemonade with the energizing and health-boosting effects of Rejuvenate!™ (Original Greens), the first superfood formulated to provide high levels of dietary nucleic acids (RNA, DNA).
In fact, Rejuvenate Lemonade is among the best—and tastiest—ways to take Rejuvenate! Original Greens. I make 12–32 ounces of Rejuvenate! Lemonade daily. It is especially refreshing in the summer, but it easy to make and drink year-round. Not only does it taste amazingly good, but delivers the all important therapeutic levels of dietary nucleic acids you need daily for good health.
All three Rejuvenate! superfoods offer major energizing effects by providing therapeutic levels of dietary nucleic acids (RNA, DNA). Rejuvenate! superfoods are the only superfoods dedicated to supplying high levels of dietary nucleic acids. Yet, Rejuvenate!™ (Original Greens) is the most densely packed with dietary RNA, providing 340 mg per serving (one small scoop)!! A single container provides 42 servings—sufficient for six weeks of daily use.
MAKE REJUVENATE!™ LEMONADE
Make Rejuvenate! Lemonade with fresh lemons or limes, maple syrup (or other natural sweeteners), purified water, cayenne pepper (optional), and Rejuvenate!™ superfood. If you don’t have fresh lemons or limes, substitute bottled lemon juice (like the Santa Cruz brand organic 100% lemon or 100% lime juice).
REJUVENATE!™ LEMONADE RECIPE
Fresh Lemons or Limes (1–2) Purified Water (8–32 ounces) Grade B Maple Syrup (1–2 tbsp) Cayenne Pepper (1/4 tsp or pinch) Rejuvenate!™ (Original Greens) (1–4 scoops)
Squeeze the lemons (using a citrus juicer or press). Aim to squeeze 2–4 tbsp juice. Mix lemon juice into your container of water. Add 1–2 tbsp maple syrup or to taste. You can also try using stevia, xylitol, or other natural sweeteners. Add a pinch of cayenne pepper (optional). Mix 1–4 scoops of Rejuvenate! (Original Greens) superfood. In hot weather, try adding a few ice cubes. Stir and enjoy!
Rejuvenate! Lemonade is excellent when modified to include small amounts of other juices (e.g., blueberry or pomegranate) of your choice, or other Rejuvenate! superfoods (Rejuvenate! Plus or Rejuvenate! Berries & Herbs).
Rejuvenate!™ Original Greens is the most nutrient-dense, and darkest-green superfood in HPDI’s Rejuvenate! line.
These nutrients ensure the body effectively utilizes the dietary nucleic acids in Rejuvenate! Original Greens. They also help this unique high-RNA superfood support your health beyond what might be expected of the collection of individual nutrients—a process known as “synergy” that leverages the benefits of all ingredients in Original Greens into something more than the sum of its parts.
FINAL WORDS: WHY REJUVENATE! LEMONADE?
Rejuvenate!™ Original Greens was the first in the Rejuvenate! line of superfoods. More than the others, it is nutrient-dense in terms providing the richest amount of dietary nucleic acids per unit weight. It also remains the most cost-effective per serving.
While it does not contain a built-in multivitamin (like Rejuvenate! PLUS and Rejuvenate! Berries & Herbs) or a comprehensive herbal sub-formula (like Berries & Herbs), Rejuvenate!™ Original Greens remains most popular among “hard core” nutrition customers and healthy food purists, as well as individuals seeking the most rapid detoxification and cleansing effects. Does this sounds like you or your clients? Then start with “Original Greens,” make healthy RNA-rich lemonade, and enjoy all the tasty benefits!
The combination of fresh lemonade and Rejuvenate! Original Greens will help hydrate, cleanse, purify, and detox…and simply is a tasty and energy-boosting, power-up drink like no other!
Lemonade made with Rejuvenate! Original Greens packs a potent, high-RNA punch.