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THE NEED FOR IODINE SUPPLEMENTATION

Dr. Hank Liers PhD iodine supplementationFred Liers PhD iodine supplementationThe Orthomolecular Medicine News Service (OMNS) published on June 12 “The Need for Iodine Supplementation.” We believe strongly in the need for iodine supplementation, especially given the fact that more than 90% of the US population is iodine deficient. For this reason we make available both Nascent Iodine and Lugol’s Iodine Solution 2 to our customers.

We present the full OMNS article (below), as a source of valuable information to our resellers and Creating Health Naturally readers. The factors contributing to massive-scale iodine deficiency remain virtually unchanged over decades. This has led to a greater need for educating health professionals and individuals about the critical importance of iodine supplementation.

Another useful article discussing the benefits of iodine supplementation was published August 2 by Dr. Mark Sircus, OMD: “Iodine, Thyroid and Low Body Temperature.” ~

The Need for Iodine Supplementation

by Wojciech Rychlik, PhD

(OMNS, June 12, 2017) Feeling tired, having low energy or depression, gaining weight, memory problems, having dry skin, dry mouth, or immune system issues? There is good chance your body needs iodine supplementation. Why iodine? Because this essential to human health element has been singled out as dangerous, for several obscure reasons, and it has been gradually eliminated from our diet, and even worse, replaced by its antagonist, bromine. This trend has been termed, iodophobia (1). It is a cause of widely occurring hypothyroidism in many developed countries.

Iodine: How Much?

Iodine deficiency is associated with (2, 3, 4):

  • Fibrocystic breast disease leading to breast cancer and stomach cancer
  • Goiter (enlarged thyroid)
  • Mental issues from reduced alertness, lowered IQ, autism to cretinism, lack of iodine for the fetus leads to cretinism, and in milder cases to autism and ADHD
  • Slow metabolism, leading to tiredness, sluggishness, fatigue, apathy, depression, and insomnia
  • Inability to produce saliva, dry skin, and lack of sweating
  • Lack of optimal detoxification, especially of bromides, fluorides, and heavy metals
  • Sensitivity to temperature changes, and cold hands and feet
  • Muscle pain, fibrosis, and fibromyalgia
  • Erectile dysfunction, infertility and miscarriages, and low sex drive
  • Overweight
  • High blood pressure, and increased incidence of heart attacks and strokes

The Food and Agriculture Organization (FAO) of the United Nations has published probable safe upper limits for dietary intake of iodine (5). They range from 150 micrograms (mcg) per kilogram (kg) per day in newborn infants to 30mcg/kg/day in adults. That is 2 milligrams (2,000 micrograms) daily for a 146-pound adult. The safe upper limit is higher during pregnancy and lactation (40 mcg/kg/day).

Treatments for Hypothyroidism

The simplest method to deal with an underactive thyroid is proper supplementation with iodine, called orthoiodosupplementation. If the thyroid is damaged, then supplementation with thyroid hormones, thyroxine (T4) and triiodothyronine (T3, the main biologically active hormone) may be necessary. Supplementation (6). with these hormones should be done under close supervision of a medical professional. However, supplementation with inorganic iodine is generally much safer, as the body “knows” how much T4 and T3 need to make. There are also drugs that change physiology of iodine metabolism, but this subject is beyond the scope of this article. Pharmaceutical companies pressure doctors to avoid inexpensive orthoiodosupplementation, so you won’t likely get a prescription for inexpensive Lugol’s solution from a mainstream practitioner.

One caveat to supplementation with iodine is the autoimmune illness called Hashimoto’s disease, or chronic lymphocytic thyroiditis, which is one of the potential causes of hypothyroidism. Unfortunately, when hypothyroidism is diagnosed, the possibility that Hashimoto’s disease underlies this condition has not always been properly tested. Therefore, Hashimoto’s disease has often been misdiagnosed. Doctors usually treat this condition with hormone replacement therapy, and some believe that excessive iodine intake may trigger it in susceptible people (7). Always ask your doctor if iodine supplements are right for you.

History of Iodine Usage and “Iodophobia”

This subject has been covered in detail by Dr. Guy E. Abraham (8,9,10). The iodine element was discovered in 1811 by B. Courtois. In 1850–1853 A. Chatin noted that goiter and cretinism are rare in geological zones rich in iodine and frequent where iodine is in short supply, and that goiter can be prevented by iodine supplementation. In 1895 E. Baumann proposed that iodine is the active element in the thyroid gland.

By the time Bauman identified large concentrations of iodine in the thyroid gland in 1895, pharmaceutical and apothecary preparations containing iodine, excluding thyroid extracts, were widely used as a panacea.

To quote Kelley: (11) “The variety of diseases for which iodine was prescribed in the early years is astonishing – paralysis, chorea, scrofula, lacrimal fistula, deafness, distortions of the spine, hip-joint disease, syphilis, acute inflammation, gout, gangrene, dropsy, carbuncles, whitlow, chilblains, burns, scalds, lupus, croup, catarrh, asthma, ulcers, and bronchitis – to mention only a few. Indeed, tincture of iodine, iodoform, or one of the iodides, was applied to almost every case that resisted the ordinary routine of practice; and between 1820 and 1840 there appeared a remarkable series of essays and monographs testifying to the extraordinary benefits to be achieved by this new and potent remedy.”

Unfortunately, these monographs have virtually disappeared from US medical libraries. In the mid-1800s, iodine treatments of some diseases called for ingestion of gram (1,000 mg) amounts per day. However, most treatments were from 5 to 50 mg daily. The recommended daily amount of iodine by Dr. G. E. Abraham is 0.1-0.3 ml Lugol containing 12.5-37.5 mg elemental iodine. This is the amount of iodine needed for whole body sufficiency, based on a recently reported iodine/iodide-loading test (12). Thyroid gland sufficiency for iodide is achieved with a lower dose.

Lugol's iodine supplementation

The first iodophobic authority emerged in early 1900s. Prof. T. Kochler reported that he suffered from overactive thyroid following ingestion of iodide (just a single individual case, not a statistical research study!) Despite this, the number of applications grew. In an International Index published in 1956, and devoted exclusively to iodine pharmaceuticals, no less than 1,700 approved iodine-containing products were listed. In 1948 Wolff and Chaikoff published that a serum inorganic iodide level at a concentration of 1 µM blocks (one micromolar) the synthesis of thyroid hormones, resulting in hypothyroidism and goiter in rats. But this conclusion was erroneous as they even did not measure thyroid hormones in the rats studied, and of course, hypothyroidism and goiter were not observed in those rats. Many organic forms of iodinated drugs were quite poisonous. Unfortunately, medical establishment did not make a distinction between organic and inorganic forms of iodine, and iodophobia became more popular.

Decades ago, iodine was added to bread so that one slice contained 150 mcg of iodine (the current recommended daily allowance). In the 1980s, bromine replaced iodine in bread. Since bromide is an antagonist to iodine (it is goitrogenic), it worsened iodine deficiency in the US. Moreover, a big push to remove salt from our diet (the only grocery item still supplemented with iodine) exacerbated the problem. The only developed nation that resisted iodophobia is Japan, statistically the healthiest and longest living nation on the planet. Their average daily consumption of iodine is around 5 mg, with various reports ranging from 1 mg to 18 mg. In a study of reported daily iodine intake versus total number of clinical symptoms, an intake of approximately 1 mg per day correlated with the lowest number of reported symptoms, that is, the highest level of health (13). Recent popularization of bromides in our food supplies likely increased this amount.

According to Dr. Abraham, (14) “proper amounts of iodine in the food supply should be considered one of a nation’s greatest assets. Removing iodine from the food supply is a major mistake. Supplying a daily intake of iodine sufficient for the whole body (100-400 times the RDA) gives protection against goitrogens and radioactive iodine/iodide fallout; improves immune functions, resulting in an adequate defense system against infection; decreases singlet oxygen formation which is the major cause of oxidative damage to DNA and macromolecules, resulting in an anticarcinogenic effect in every organ; results in a detoxifying effect by increasing urinary excretion of the toxic metals lead, mercury, cadmium, and aluminum, as well as the goitrogens fluoride and bromide; normalizes hormone receptor functions resulting in improved response to thyroid hormones both endogenous and exogenous; and results in better control of blood sugar in diabetic patients; stabilizes cardiac rhythm, obviating the need for the toxic sustained release form of iodine, amiodarone; and normalizes blood pressure without medication in hypertensive patients. Iodine deficiency is the major cause of cognitive impairment, worldwide.”

The Iodine-Cancer Connection

The body requires iodine to metabolize both omega-3 and omega-6 fatty acids. A substance called delta-iodolactone, a derivative of arachidonic acid, which is produced in the thyroid gland and breast tissue, prostate, colon, and the nervous system, is a regulator of a process called cellular apoptosis (“cell death”). Ascorbic acid is required to stimulate intracellular hydrogen peroxide synthesis that, in turn, provides the energy to make iodine free radicals necessary for this reaction. When the level of delta-iodolactone is high enough, the process of apoptosis can then kill cancer cells. (15)

Unfortunately, the recommended daily allowance (RDA) for iodine — about 150 mcg per day — will not allow delta-iodolactone to be efficiently formed in the thyroid gland. The thyroid requires higher iodine concentrations to efficiently produce it. Researchers have found that 100 times the RDA amount of iodine is optimal to produce delta-iodolactone. That equates to taking about 15 mg of iodine per day (15,16). These findings are important because they imply that there are some biochemical reactions that require much larger amounts of iodine than the current RDA. The mechanism by which delta-iodolactone induces cell death may be an important pathway for curing some types of cancer.

Forms of Iodine

Inorganic iodine exists in 6 oxidative states, from -1 to +7. The most reduced form (with most electrons) is iodide (I); an example is potassium iodide. The diatomic form of elemental iodine I2, has no electrical charge. Monoatomic iodine also has no electrical charge, but is unstable and highly reactive (free radical, labeled as an I with a dot, I* ). It can be produced by exposing I2 to ultraviolet light. Electric and magnetic fields won’t do it, as is sometimes incorrectly suggested. More oxidized forms of iodine are: hypoiodite (I+1), iodite (I+3), iodate (I+5), and periodate (I+7). The body’s metabolism may convert (reduce) these forms to biochemically available iodide, but at the cost of depleting its antioxidants. All forms of positively charged iodine are relatively poisonous, with established lethal doses (LD50) in the range of 35 to 2100 mg/kg. Elemental iodine (I2) and iodides (I) are non-poisonous. However, a bad “antiseptic” non-culinary taste of iodine (I2) suggests to our senses that this is not so good choice for supplementation.Nascent iodine supplementation

Despite that adverse taste, almost all the research on iodine supplementation has been done using Lugol’s Solution (17). The original solution is called 5% Lugol’s Iodine, but in reality it consists of 12.5% iodide/iodine or (I/[I3]) ions. Two drops of Lugol’s Solution (0.1 ml) contain 12.5 mg iodine/iodide mix. Iodine tablets that are a solid form of Lugol’s solution, were created to mask the taste and make the doses more precise for dietary supplementation.

I should mention a few points about Edgar Cayce’s atomidine. This famous visionary wrote several articles about the best form of iodine supplement (18). Some claim that this was iodine trichloride, but that cannot be true as this compound is toxic by ingestion and damaging to mucous membranes. It decomposes to ICl and poisonous gas Cl2 at 77 degrees C and also in water at room temperature (19). Most likely Cayce’s atomidine was simply a 1% iodine solution (I2) in 95% ethanol. I am surprised that there are educated people, even medical doctors who claim that “elemental monoatomic iodine” preparations (Atomidine, Nascent Iodine etc.) are the best forms of iodine supplements. May be it has something to do with efficient marketing? Elemental Iodine (I2) is soluble in glycerin. Replacement of ethanol with glycerol indeed makes these supplements more consumption-friendly, so they are sold by some vendors as superior products to Cayce’s ethanol-formulated one. Personally, I think glycerol-based I2 supplements are inferior to iodides; however, they are excellent antiseptics.

To defend the validity of Cayce’s vision, in thyroid, I ion and amino acid tyrosine react through a short intermediate step by forming monoatomic I* free radical (selenium and hydrogen peroxide are involved) to make monoiodotyrosine. Diiodotyrosine is formed analogical way, and finally, two of these molecules combine to produce thyroxine. All those steps are carried by the enzyme thyroid peroxidase, which is normally attached to the protein thyroglobulin. So, yes, monoatomic iodine I* exists in human bodies, and it directly reacts with tyrosine, but no, it wouldn’t be healthy to consume iodine free radicals as their high reactivity would prevent safe transport throughout the body.

In the mid-1930s the thyroid hormone thyroxine became available on the market. This was a blessing for people who had damaged their thyroid. Unfortunately, doctors started to prescribe this hormone to just about anybody with hypothyroidism, thinking that they can control better thyroid hormone levels than our bodies can. And, the “iodine is iodine, no matter what form” mentality became a dangerous trend, because most medical professionals do not fully appreciate the difference between the raw nutrient (iodine) and its product (hormone).

The pharmaceutical industry came up with lots of organic forms of iodine (NB: organic, meaning that iodine is bound to a carbon-atom-containing molecule and NOT meaning it’s grown in a pesticide-free environment), all relatively toxic and certainly not to be used without strict medical supervision. Only inorganic forms of iodine, I and I2, are safe for supplementation (20,21). Further, high doses of these supplements should still be supervised by your doctor.

Iodine Uses

Iodine plays critical role in human metabolism. Many researchers believe the RDA value of 150 mcg for iodine is too low, especially when this element is commonly substituted with competing element bromine. Therefore, the main use of iodine in dietary supplementation is to enable optimal thyroid function. There are a number of medical conditions where iodine is either essential or helpful. For best results, iodine/iodide should be supplemented with selenium, magnesium, copper (there is usually enough of it in tap water as copper is widely used in plumbing), vitamin B2 (riboflavin) and B3 (niacin). Ask your doctor before taking any iodine supplements, especially if you are on medications.

Elemental iodine (I2) is antibacterial and antifungal, so iodine or iodine/iodide solutions are commonly used topically to sterilize wounds, or internally to fight infections, such as vaginitis and sore throat, and also to sanitize drinking water. Because iodine is antibacterial, drinking it may cause friendly bacterial flora to suffer and result in diarrhea and stomach cramps (the same applies to Lugol’s solution, but to a lesser extent as it contains iodides as well).

Ingestion of iodides prevents the incorporation of destructive radioactive iodine into the body (mainly by the thyroid) in case of nuclear accidents. It also may help flushing already incorporated radioactive iodine from the thyroid, although too much iodine inhibits secretion of T4/T3 from the gland.

Common-Sense Cautions

Overdosing any of the iodine supplements can lead to swollen salivary glands, metallic aftertaste and skin rash and itching (that are usually due to rapid process of detoxification from heavy metals fluorides and bromides), faster heartbeat or palpitations and diarrhea. When supplementation is stopped, these symptoms will usually disappear quickly, often within one day. Iodine stabilizes thyroid hormone production, so it is an adaptogen, but in rare cases, such as acquired allergy to iodine (Hashimoto’s disease), it may actually misbalance it. In some cases, iodine supplementation can cause hypothyroidism, so it’s important to get checked by your doctor to make sure that your thyroid function is not worsened by supplementation. Some authors advising caution are Alan Christianson (22), Jeffrey Dach, (23) and Alan Gaby (24). Testing of levels of thyroid hormones along with testing and supplementation of mineral nutrients such as selenium, zinc, copper, magnesium calcium, and other trace minerals may prevent problems in cases where high doses of iodine/iodide might tend to cause Hashimoto’s disease. (23)

Inorganic Iodine Availability

The most common form of iodine supplement is Lugol’s solution (17). The original solution contains 5% of iodine and 10% iodide. Solid pill forms of Lugol’s solution are sold under several brand names. Potassium iodide (KI), my favorite iodine supplement, is available as tablets as well. Various products with kelp or other seaweed extracts contain iodides as well. Check the label when you buy as some of them are very diluted.

It is difficult to find inexpensive elemental iodine (I2) solution in alcohol. You can buy iodine crystals online and make the proper solution by yourself very easily (using either alcohol or glycerol). The monoatomic iodine concept is simply a marketing gimmick that has been created to inflate the price several fold. Note that if the monoatomic claims were really true, few would really want to drink free radicals, the only monoatomic form that exists. Iodine free radicals are not transported freely in our bodies because they are too reactive. Elemental iodine preparations, including iodine dissolved in glycerol, may be helpful products for external antiseptic use rather than a supplement.

Another form of iodine supplement includes a mixture of algae and thyroid extract in glycerin, water and ethanol. This is likely not harmful because it contains T3 and T4 only in very small amounts, and the recommended serving size is also small. Other complex formulae that contain elemental iodine are a useful antiseptic, but not a good supplement. Iodine trichloride should be avoided as a supplement because it is too toxic.(19)

Summary

The established RDA allowance for iodine (150 mcg/day) is inadequate for many individuals. In order to maintain optimum health, adults need 2-5 mg of iodide daily. Actually, this is in line with the upper safe limit of dietary intake of iodine established by FAO (30 mcg/kg/day). In case of a dysfunctional thyroid or other illnesses, such as fibrocystic breast disease or cancer, 15-50 mg daily may be needed. Ask your doctor about the alternatives to hormone therapy or taking iodine-containing organic drugs, because inexpensive orthoiodosupplementation would usually not be his/her first choice.

The best and safest form of iodine supplementation for a healthy adult is iodide. Iodides are naturally produced in larger quantities by various seaweeds.

Please consult your doctor about iodine supplementation, as in your particular case it may be contraindicated.

References:

1. Abraham GE. The History of Iodine in Medicine Part III: Thyroid Fixation and Medical Iodophobia. http://optimox.com/pics/Iodine/IOD-16/PUB_16.htm

2. Dommisse J. MD Best Kept Secret (2009) http://www.westonaprice.org/modern-diseases/best-kept-secret/#sthash.vdrKPaJw.dpuf

3. http://theiodineproject.webs.com/addadhdautism.htm

4. Hamza RT1, Hewedi DH, Sallam MT. (2013) Iodine deficiency in Egyptian autistic children and their mothers: relation to disease severity. Arch Med Res. 44(7):555-61. http://www.ncbi.nlm.nih.gov/pubmed/24120386

5. http://www.fao.org/docrep/004/y2809e/y2809e0i.htm

6. Abraham GE. The Concept of Orthoiodosupplementation and Its Clinical Implications. https://www.optimox.com/pics/Iodine/IOD-06/IOD_06.htm

7. http://www.webmd.com/women/hashimotos-thyroiditis-symptoms-causes-treatments#1

8. Abraham GE. The History of Iodine in Medicine Part I: From Discovery to Essentiality. http://optimox.com/pics/Iodine/IOD-14/PUB_14.htm

9. Abraham GE. The historical background of the Iodine Project. http://www.optimox.com/pics/Iodine/IOD-08/IOD_08.htm

10. Abraham GE. The History of Iodine in Medicine Part II: The Search for and the Discovery of Thyroid Hormones. http://optimox.com/pics/Iodine/IOD-15/PUB_15.htm

11. Kelly FC. “Iodine in medicine and pharmacy since its discovery , 1811-1961.” Proc R Soc Med, 1961; 54:831-836. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1869599/

12. Abraham GE. “The safe and effective implementation of orthoiodosupplementation in medical practice.” The Original Internist, 2004; 11(1):17-36. http://www.hakalalabs.com/Research/Abraham_OI_Mar04.pdf

13. Fallon Morell S. The Great Iodine Debate (2009) The WestonA. Price Foundation, http://www.westonaprice.org/modern-diseases/the-great-iodine-debate/

14. Abraham GE. The Wolff-Chaikoff Effect: Crying Wolf? https://www.optimox.com/pics/Iodine/IOD-04/IOD_04.html

15. Brownstein D. The Cancer-Iodine Connection, (2015) http://www.newsmax.com/Health/Dr-Brownstein/iodine-cancer-cell-death-fish-oil/2015/06/10/id/649877/

16. 6-Iodolactone, key mediator of antitumoral properties of iodine, M. Nava-Villalba, C. Aceves, (2014) Prostaglandins & Other Lipid Mediators 112, 27-33. https://www.researchgate.net/publication/263856609_6-Iodolactone_key_mediator_of_antitumoral_properties_of_iodine

17. Bacteriological Analytical Manual, R40 Lugol’s Iodine Solution (2001), http://www.fda.gov/Food/FoodScienceResearch/LaboratoryMethods/ucm062245.htm

18. Review of Atomidine, International Wellness Directory, http://www.mnwelldir.org/docs/reviews/atomidine.htm

19. Material safety data sheet, http://www.mnwelldir.org/docs/history/Iodine_Trichloride.pdf

20. Abraham GE. The historical background of the Iodine Project http://www.optimox.com/pics/Iodine/IOD-08/IOD_08.htm

21. Abraham GE and Brownstein D. A Rebuttal of Dr. Gaby’s Editorial on Iodine. (2005) Townsend Letter, The Examiner of Alternative Medicine, http://www.townsendletter.com/Oct2005/gabyrebuttal1005.htm

22. Christianson A. http://www.integrativehealthcare.com/why-i-discourage-high-dose-iodine/

23. Dach J. http://jeffreydachmd.com/iodine_is_safe

24. Gaby A. http://www.townsendletter.com/AugSept2005/gabyiodine0805.htm

Nutritional Medicine is Orthomolecular Medicine

Orthomolecular medicine uses safe, effective nutritional therapy to fight illness. For more information: http://www.orthomolecular.org

Access the original OMNS article, “The Need for Iodine Supplementation”: http://www.orthomolecular.org/resources/omns/v13n14.shtml

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USING HPDI FOUNDATIONAL SUPPLEMENTS

Fred Liers PhD foundational supplements nutritionHPDI foundational supplements are designed to provide a complete range of essential nutrients that complement a healthy diet and lifestyle. They help ensure sufficient levels of nutrients required for good health.

We define foundational supplements as basic or “core” supplements that should be part of everyone’s daily regimen. They are the foundation of a complete nutritional supplement program.

HPDI has a three-tiered system of nutritional supplements: 1) Foundational Supplements, 2) Enhancement Formulas, and 3) Specific-Condition Formulas. All three tiers comprise a complete nutritional supplement program.

When properly combined, these three tiers of nutritional supplements help create optimal health. This month, I explain how to use HPDI foundational supplements, the base or bottom tier of the system (see cone diagram below).

The HPDI supplement system can be visualized as a cone having a base of Foundational Supplements ascending toward an apex of Enhancement Formulas and Specific Condition Formulas.

foundational supplements HPDI system

The HPDI Supplement System includes six types of Foundational Supplements forming its base.

USING HPDI FOUNDATIONAL SUPPLEMENTS

My intent is to guide consumers and health care professionals to decide the foundational supplements that are best for their purposes, and that provide the most effective results.

For anyone new to HPDI’s Foundational Supplements system, we recommend six basic types of supplements. The six categories are: 1) multivitamin formulas, 2) vitamin C / antioxidant formulas, 3) essential fats, 4) high-RNA foods (Rejuvenate! superfoods), 5) gut health formulas, and 6) hydrogen formulas.

We established the original three types of foundational supplements about 1988. We have always suggested that clients and health professionals take and/or recommend multivitamins, vitamin C and antioxidants, and essential fats.

About 10 years ago, we added high-RNA foods (like Rejuvenate! superfoods) as a fourth type of foundational supplement because research indicates dietary nucleic acids are essential nutrients—see our blog articles on nucleic acids, Benjamin S. Frank, MD, PhD, and about Rejuvenate! superfoods (Original, Plus, and Berries & Herbs).

Two categories of foundational supplements are new: gut health formulas and hydrogen formulas. Hank wrote an article (Amending the HPDI Foundational Program) about these changes in April. We added these two categories after much consideration regarding their benefits, and have written extensively about them in this blog (see resources section below).

The entire HPDI supplement system is depicted (above) as a cone. The six types of foundational supplements form the base of the cone. Enhancement Formulas and Specific-Condition formulas sit above toward the apex.

ultimate protector foundational supplements

Ultimate Protector Nrf2 formula is a foundational supplement in the vitamin C / antioxidant category.

HOW I USE HPDI FOUNDATIONAL SUPPLEMENTS

I use all six types of HPDI foundational supplements. I take the following supplements (below) and present them here as an example of how they can be integrated into a complete supplement regimen. Foundational Supplements I take:

1. Multivitamin: Hank & Brian’s Mighty Multi-Vite! (4 per day in divided doses)

2. Vitamin C / antioxidants: PRO-C (6-8 per day) and Ultimate Protector Nrf2 activator (8-12 per day)

3. Essential Fats: Essential Fats Plus E (4 per day)

4. Rejuvenate!™ superfood: All three Rejuvenate! superfoods (2-8 scoops per day)

5. Gut Health: RESTORE For Gut Health (1-2 ounces per day) and Prescript-Assist™ probiotic (soil-based organisms) (1-3 per week)

6. Hydrogen: Megahydrate (2-6 per day)

Taking one supplement from each of the six foundational supplement categories builds, supports, and maintains optimal health.

We at HPDI recommend everyone take one of each type of foundational supplement. That is, we suggest an individual select for personal use a multivitamin, vitamin C/antioxidant formula, essential fats formula, Rejuvenate!™ superfood (or other high-RNA superfood), hydrogen product, and at least one gut health product (depending on their gut-health needs).

Similarly we suggest health care professionals recommend for their clients one of each of the six types of foundational supplements.

The other two categories in the HPDI nutritional supplement system are Enhancement Formulas and Specific-Condition Formulas (see cone diagram). These are not foundational supplements. However, I include the supplements I take in these categories for the sake of completeness, as well as to show how Enhancement and Specific-Condition Formulas integrate with Foundational Supplements to form a complete supplement program providing a wide-range of essential nutrients required for health.

Enhancement Formulas I take include: B-Complex-50 (B complex), Myo-Mag (magnesium/malic acid), Ubiquinol-50, Bone Guardian, and Vitamin D3 Plus.

Specific Condition Formulas I take include: Joint Health Formula, Allergy Support Formula, Eye & Vision Formula, Intestinal Rejuvenation Formula, and Warrior Mist (pain topical), and Warrior Sleep (sleep topical).

While I take supplements from all three categories (Foundationals, Enhancements, and Specific-Condition) in the HPDI supplement system, I always prioritize foundational supplements—I take them first—because they are base on which my personal supplement program rests.

Foundational supplements should be the base on which your supplement program—or those of your clients—rests, as well.

We have seen the results of taking a complete set of foundational supplements. They work because the nutrients they provide are needed by everyone.

HPDI foundational supplements multivitamin

Muti Two Caps is a high-potency multi with coenzyme forms for optimal utilization in the body.

FOUNDATIONAL SUPPLEMENTS: RESULTS

Individuals who take all types of foundational supplements do best in terms of optimizing health. The reason is that all six types provide nutrients required for good health.

I can attest that HPDI Foundational Supplements are effective for improving or maintaining good health. In addition, I have witnessed numerous instances where individuals benefit most greatly when taking all four–and now all six–types of foundational supplements.

Each of the six categories of foundational supplement provide unique benefits. Yet, each performs functions required by the human body for good health. That is one reason when they are combined they exert synergistic effects for health going far beyond the benefits of using, one, two, or three of the types of foundational supplements.

WHEN FOUNDATIONAL SUPPLEMENTS ARE NOT PRIORITIZED

I talk to people who may or may not take a multivitamin. And they may or may not take vitamin C. Yet, they may take calcium for their bones, glucosamine for their joints, and lutein for their eyes. Or they may take a low-potency, off-the-shelf multivitamin providing merely the RDA for all nutrients.

There is nothing wrong with individuals taking supplements they regard as important or useful. But that cannot guarantee that a wide range—and sufficient levels—of nutrients necessary for health are available to the body on a regular basis.

In fact, I regard the supplement intake programs of most persons to be “hit-or-miss.” They may consume nutrients important for a few functions in the body, yet fail to obtain other essential nutrients required for the nutrients they take to work most effectively. We have written extensively on this topic on our website and in blog articles (see below).

Not taking regularly a complete set of foundational supplements likely means key nutrients (and key levels of nutrients) go missing. Over time, this means fewer and lower levels of nutrients available to support the body’s needs for them at levels known to sustain the good health.

The best way to ensure a sufficient range of nutrients at plentiful levels is to take foundational supplements. After a baseline of nutrients is established by taking foundational supplements, additional supplements can be added, as necessary.

rejuvenate superfood foundational supplements

High-RNA foods like Rejuvenate! PLUS superfood provide dietary nucleic acids important for health.

A COMPLETE SYSTEM OF SUPPLEMENTS, INCLUDING FOUNDATIONALS

After obtaining sufficient levels of basic nutrients required for health, then a person can add (or you can recommend) specific nutrients or formulas that target certain problems or issues. This is the basis for HPDI development of Enhancement Formulas and Specific-Condition Formulas.

Nutritional supplements in the categories of Enhancement Formulas and Specific-Condition Formulas therefore “stack” on top of HPDI’s Foundational Supplements (see cone diagram above). In this way, a complete nutritional supplement program begins with the most essential nutrients and continues with customizations based on the unique needs of an individual.

ENHANCEMENT FORMULAS

Enhancement Formulas in the HPDI system are supplements we regard as falling into the next tier in terms of importance, at least for most people. They do not necessarily provide essential nutrients, and yet many people (including myself) benefit significantly from them.

Enhancement Formulas include: magnesium formulas (topical and capsule), Vitamin D3 Plus, Nascent Iodine, Vitamin B12 (methylcobalamin), mushroom-based products (like Immune-Assist™), Prolyt (proteolytic enzymes), Digase (plant-based enzymes), and Warrior Mist (topical pain reliever), and many other formulas.

SPECIFIC-CONDITION FORMULAS

In the HPDI system, individuals can add (in a modular way) various formulas and single nutrients designed to support a particular set of needs or a target a specific condition.

We offer a complete range of supplements (almost 100) including a range of supplements formulated to address specific conditions. These include Joint Health Formula, Eye & Vision Formula, Blood Sugar Support, Allergy Support Plus, Prosta Plus, and many other formulas.

ONE SYSTEM. THREE TIERS. HPDI SUPPLEMENTS.

HPDI Foundational Supplements collectively form the base tier of a complete nutritional supplement system comprised of three tiers: 1) Foundational Supplements (six types), 2) Enhancement Formulas (or simply “Enhancements”), and 3) Specific-Condition Formulas.

Foundational Supplements are necessary because they provide nutrients foundational to health. Taking them daily or recommending your clients take them daily can help mean big differences in health, nutrition, and quality of life.

We at HPDI design our nutritional supplements to be the most effective dietary supplements available. HPDI products are known for: 1) Advanced Formulation (including use of superior forms of nutrients), 2) Ultra-High Purity, 3) Avoidance of Harmful Ingredients, and 4) being made with Good Manufacturing Practices (GMP). For more details, please see The HPDI Difference and our Statement on Additives (Excipients).

At least 40 of HPDI’s products are formulated by Dr. Hank Liers. They fall in all categories in HPDI’s supplement system. They can be found under “Dr. Hank Liers original formulas.”

omega plus foundational supplement

Omega Plus provides exceptionally well-balanced omega-3 and omega-6 fatty acids.

FOUNDATIONAL SUPPLEMENTS: FREQUENTLY ASKED QUESTIONS (FAQ)

We frequently get questions from HPDI clients and resellers regarding foundational supplements. These questions include:

“Why did you add gut health and hydrogen products to your foundational supplements program?”
We found it necessary to add categories for gut health and hydrogen because they provide nutrients that are support the body and help ensure the foundational supplement system supports health most effectively. You can read more in previous blog articles (see below).

“Which is the better multivitamin: Multi Two or Mighty Multi-Vite!™?”
It depends on whether you need more B vitamins or antioxidants. Multi Two provides more B vitamins and Mighty Multi-Vite™ provides more antioxidants and cofactors. I take a separate HPDI B-Complex-50 formula, so I take Mighty Multi-Vite!™ as my primary multivitamin.

“What are the differences between Rejuvenate!™ Original, PLUS, and Berries & Herbs superfoods?”
They each provide about 340 mg of dietary nucleic acids. Original is the “greenest” with a large percentage of dietary nucleic acids coming from chlorella and spirunlina. PLUS is our most popular and 30% is identical to Original with more protein and a built-in multivitamin complex. Berries & Herbs contains no greens, yet more nucleic acids (390 mg), protein, and a built-in multivitamin. See our Rejuvenate! comparison page for more information.

“Should I take a vitamin C formula with antioxidants like PRO-C or one with Nrf2 activators like Ultimate Protector?”
Both provide vitamin C and Nrf2 activators, but Ultimate Protector provides more types of Nrf2 activators. Ultimate Protector capsules are smaller than PRO-C capsules, so a daily dose may require taking more capsules.

“How important are hydrogen supplements?”
Very important for energy production, recovery, antioxidant functions, and gut health. Hydrogen supplements like Active H2 and Megahydrate ensure high levels of hydrogen are available in the body.

What are your best products for supporting gut health?
It depends on your needs: cleansing (Intestinal Rejuvenation Formula), probiotic/microbiome support (Prescript-Assist™), or tightening tight junctions in the gut (RESTORE)? We offer products for all these purposes.

These are just a few questions frequently asked about HPDI foundational supplements. If you need more information about products, please contact the HPDI office (800-228-4265) or email support@healthproductsdistributors.com.

You can also contact Fred Liers, PhD (520-400-0155) or Hank Liers, PhD (formulator) with questions you may have regarding products, ingredients, or formulation.

SOURCES AND RESOURCES

Foundational Supplements

HPDI Full Product Overview

The Need for Foundational Supplements (.pdf)

The HPDI Difference (4 Pillars of Formulation)

HPDI BLOG ARTICLES

Amending the HPDI Foundational Supplements Program

Foundational Supplements Remain Fundamental

Vitamin C / Antioxidants

PRO-C and Ultimate Protector Comparison

Questions and Answers about Ultimate Protector

The Amazing Healing Potential of Natural Nrf2 Activators

Ultimate Protector™: First Impressions

Ultimate Protector™ Brunswick Labs ORAC5.0™ Test Results

Preventing Free-Radical Damage Using Ultimate Protector™

Description and Comparison of ORAC Tests for Well Known Plant Ingredients and Ultimate Protector™

Ultimate Protector and the Role of Foundational Supplements for Health

Natural Phytochemical Nrf2 Activators for Chemoprevention

New Directions for Preventing Free Radical Damage

Review of Scientific Research on Oligomeric Proanthocyanidins (OPC)” by Dr. Hank Liers

“Vitamin C – An Amazing Nutrient” by Dr. Hank Liers

Rejuvenate! Superfoods

Rejuvenate! Berries & Herbs: Ingredients for Optimal Nutrition

9 Things to Know About Rejuvenate!™ Superfoods

High-RNA Rejuvenate!™ Superfood

Get Results with Rejuvenate! Superfoods

Dietary RNA for Athletic Performance

DIETARY NUCLEIC ACIDS – DR. BENJAMIN S. FRANK, PART 1

DIETARY NUCLEIC ACIDS – DR. BENJAMIN S. FRANK, PART 2

Super-Tasty Morning Nutritional Drinks

Hydrogen

The Science Behind Megahydrate

Hydrogen for Optimal Health

Wonders of Molecular Hydrogen

Gut Health

Gut Health – Effects of Glyphosate and Antibiotics

Gut Health – Intestinal Rejuvenation Formula

PRODUCTS

Vitamin formulas, including multivitamins

Mighty Multi-Vite!

Multi Two Caps

Rejuvenate!™ Berries & Herbs

Rejuvenate!™ PLUS

Rejuvenate!™ (Original)

Rejuvenate! Superfoods: Product Comparison

Ultimate Protector™ Nrf2 Activator (vitamin C/antioxidant)

PRO-C (Vitamin C/Antioxidant formula)

Intestinal Rejuvenation Formula (gut health)

Restore For Gut Health (lignite formula)

Active H2 (hydrogen)

Megahydrate (hydrogen)

Prescript-Assist™ (probiotic/prebiotic)

HPDI FOUNDATIONAL SUPPLEMENTS

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FOUNDATIONAL SUPPLEMENTS REMAIN FUNDAMENTAL

Fred Liers PhD foundational supplements remain fundamentalI spoke with an old friend recently. I will call him Joe.

Joe has digestive tract issues, including extreme diverticulosis. While I have provided him with suggestions for improved nutrition and supplement use in recent years, he hasn’t followed any of my recommendations seriously.

Instead Joe opted for a more conventional route. Now his situation has worsened dramatically, and he says he’s ready to start a program of improved nutrition and supplements. That’s good, even though it would be easier had he started sooner. Like I said, Joe is a good friend. I wish him health and happiness.

My initial advice to Joe remains the same as it would be for everyone. He should start with a dietary changes and a solid program of foundational supplements like those in the HPDI Foundational Supplements Program. He can later add enhancements and condition-specific formulas addressing his unique needs.

WHY FOUNDATIONAL SUPPLEMENTS?

The HPDI Foundational Supplements program was developed by Hank Liers, PhD to provide optimal levels of basic nutrients important for good health. In our experience, the HPDI program works to support vibrant health. It also helps cover gaps left by poor diet, incomplete nutritional supplementation, and imbalances due to genetic factors. It helps to compensate for lower nutrients levels found in many modern foods both processed and/or produced by modern industrial agricultural methods (i.e., that deplete soils or block nutrient uptake).

Read more the HPDI Foundational Supplements Program.

6-types-supplements-foundation

HPDI’s foundational supplements program includes six categories of dietary supplements.

JOE’S DIET IS NOT SO GOOD

I don’t like to be overly prescriptive about food. But Joe is a “carb” lover and with a history of consuming processed, high-sugar foods, and junk foods. For example, processed breads, donuts, candy bars, and soda have been staples for years. It doesn’t help many of these foods either are GMO or high in glyphosate (the main ingredient in the herbicide RoundUp), which is known to produce adverse gastrointestinal (and other harmful) effects.

He has reduced his intake of high-carb, sugary foods in recent years. In fact, he has significantly cut back on simple sugars because he finds they drain his energy and don’t help his digestion.

I suggested he continue cutting back on simple carbs and sugars, and that he add more fresh vegetables and high-quality proteins to his diet. I recommend organically grown and non-GMO foods.

I can’t say what caused Joe’s diverticulosis. But I can say that changes in his diet are necessary to support optimal health, as well as healing of damage to his digestive tract.

It doesn’t help that Joe takes several drugs, including a long-term antibiotic for a stubborn urinary tract infection, and a laxative (containing polyethylene glycol) for his constipation and diverticulosis. These drugs may help in the short term, but they far from ideal for long-term use.

Joe himself isn’t pleased with his need for drugs. He intends ultimately to stop them when possible.

He has been having trouble sleeping in recent years. I suspect this may be related to his troubles with his intestinal tract, dysbiosis, and possibly issues with his microbiome.

SUPPLEMENTATION

Joe sent me his supplement schedule and results from a few health tests to review. He has “nutrition-oriented” doctors whose advice he follows quite rigorously.

I reviewed his supplement schedule and health test results. His results include some in-depth genetic tests, which provide insights into potential health concerns, and practical advice for nutritional supplementation.

IMBALANCES CALL FOR FOUNDATIONAL NUTRITION

I saw glaring gaps in Joe’s supplement schedule. There are major imbalances in his supplement program. For example, I see no multivitamins or vitamin C/antioxidant formula, which are basic to the HPDI foundational program.

Indeed, for all the good elements, his program unfortunately is hit-or-miss in terms of providing a complete spectrum of essential nutrients.

On the upside, he’s been taking a few specific-nutrient supplements daily:

5,000 mg of vitamin D (25-hydroxy).

3,000 mg of Omega-3 (EPA/DHA) and 1,000 mg of flax seed oil.

He gets some coenzyme B vitamins:

2,000 mcg of a methyl folate (MTHF)

1,000 mcg of B12 as methylcobalamin daily.

Taking these standalone coenzyme B vitamins is good because test results indicate he has the heterozygous genotype for the MTHFR C677T (C/T) and MTHFR A1298C (A/C). The presence of both polymorphisms can result in significantly reduced activity of MTHFR potentially leading to reduced production of the active form of folate (L-methylfolate).

As his test results stated: “Reduced levels of L-methylfolate lead to decreased production of neurotransmitters, reduced conversion of homocysteine to methionine, and reduced s-adenosylmethionie (SAMe) concentrations.”

GAPS: HIT OR MISS ON FOUNDATIONALS

I asked about his multivitamin and vitamin C intake. He said he takes them despite the fact they are absent from his supplement schedule. I supposed they were absent from his schedule because his doctors want to make sure he gets his vitamin D, folate, methylcobalamin, and essential fats, but aren’t too concerned about whether or not he takes a complete multivitamin, vitamin C/antioxidant formula, or complete B-complex vitamins.

Joe told me he takes a multivitamin, B-complex, and vitamin C supplement. But didn’t take all of them daily.  All three products came from a “big-box” store known for low prices.

Joe therefore consumed a few specific, advanced, medical-quality formulas at the direction of his doctors. Yet, he purchased low-end multivitamin, vitamin C, and B-complex products that can or should be the foundation of his supplement program.

His multivitamin was a low-potency formula providing only 3–500% of the daily value for most nutrients with many at exactly 100%. Not only is this multivitamin low-potency, but its forms are conventional (no coenzyme vitamins or advanced forms). Moreover, it is full of unnecessary additives and fillers like polyethylene glycol, polyvinylpyrrolidone, and sodium benzoate.

His vitamin C was 500 mg. He didn’t take it every day and when he did, he took only one or two.

WHAT I DID FOR JOE

Joe and I talked about his situation. He agreed to receive a package of supplements. Actually, I attempted several years ago to help him get onto a foundational supplements program. He took some supplements and he definitely noticed a difference in how he felt. Yet, he wasn’t ready to take a complete system of high-quality supplements. He finally agreed to try the program.

I sent him a package of HPDI supplements. It included two foundational supplements: Hank & Brian’s Mighty Multi-Vite! (multivitamin) and PRO-C (vitamin C/antioxidant formula). I did not include essential fats because he already takes them. I will send Rejuvenate! PLUS superfood and Intestinal Rejuvenation Formula in a separate shipment.

Joe now takes the Mighty Multi-Vite! and PRO-C, as well as Myo-Mag (magnesium) daily. He is already noticing he needs less of his laxative, and has scaled back his dosage. He can see the day is coming when he can wean himself entirely of it. He has updated his supplement schedule to include all of his supplements, so he can better track his supplement intake and ensure consistency.

I also sent him a Warrior Sleep for his sleeping troubles, and a bottle of Restore, which may help his intestinal tract and problems related to it.

PRO-C foundational supplements vitamin c

PRO-C is one of HPDI’s premier vitamin C / antioxidant formulas.

In forthcoming blog posts I plan to document the status of Joe’s health, including his energy levels and subjective feelings about his health. We will see how foundational supplements help him.

Not everyone is as fortunate as as Joe to have a friend who will send supplements and more importantly, talk to him in depth about nutrition and the need for foundational supplements.

WHAT JOE CAN DO FOR HIMSELF

It is my hope that Joe will follow the foundational supplements program, regain some health, and continue to improve by remaining on the program with HPDI supplements. He can take on his foundational supplements program as a mission for his own long-term health.

I also hope Joe’s experience with HPDI supplements will be an example to others who may be in similar situations. This includes individuals who don’t know where to begin, and those who take a variety of supplements yet aren’t receiving a full complement of essential nutrients.

Others who may be in similar situations to Joe’s include those who take supplements as directed by their doctor, but whose supplement schedule is “hit-or-miss,” which I suspect is a lot of people. Or those taking low-potency multivitamins or B-complex vitamins or just 500 mg of vitamin C daily. Also those taking basic supplements sporadically or whenever they “feel like it.”

Joe is far from being alone in having significant gaps in his foundation of essential nutrients that support good health. His doctors missed those gaps despite their best intentions to provide him with advanced nutrients based on genetic testing to assess potential deficiencies. “Losing sight of the forest for the trees” can happen to the best of us. In fact, the average person’s nutrient profile is not unlike Joe’s in many respects. And like Joe’s situation, foundational supplements can help close the gaps.

FOUNDATIONAL SUPPLEMENTS CAN LEAD TO BETTER HEALTH

There are many reasons I feel confident that HPDI foundational supplements will continue helping Joe. Not only am I not surprised he is noticing results, but also I’ve seen health improve in many (perhaps hundreds of) individuals when they begin a complete foundational supplements program, and then especially when they maintain it.

Good results are not surprising when the levels of nutrients increase from just 100% of the daily value for most nutrients to much higher levels.

Results improve over time when the body continues receiving high levels of essential nutrients.

Dietary supplements are generally non-toxic so there is little risk of problems when the body receives more than adequate nutrients to meet its needs.

And why take just the minimum? Minimum amounts of nutrients tend to perpetuate deficiencies when you consider factors like poor diet, increased oxidative stress, toxic exposures (leading to greater nutrient needs to support detoxification), and genetic factors (e.g., enzyme deficiencies).

multivitamins HPDI foundational supplements

HPDI Multivitamins include Mighty Multi-Vite!, Multi Two (caps and tabs), Mini Multi, and Chewable Kids Mighty-Multi!

HPDI FOUNDATIONAL SUPPLEMENTS PROGRAM

The HPDI Foundational Supplements Program until recently consisted of four types of supplement:

• High-Potency Multivitamin

• Vitamin C / Antioxidant Formulas

• Essential Fatty Acids

• High-RNA Superfoods (providing dietary nucleic acids)

Just last month, HPDI revised the Foundational Supplements Program to include two additional types of supplements:

• Gut Health formulas (such as Restore)

• Hydrogen products (such as Megahydrate and Active H2)

For more information on the revised system, see Amending the HPDI Foundational Supplements Program (blog post) by Hank Liers, PhD.

All six of these types of formulas comprise the HPDI Foundational Supplements Program. It is our belief that these six types of formulas are foundational to health regardless of whether you use HPDI’s supplements or those of another company (as long as they are high-quality, high-potency, provide the proper forms, and do not contain unnecessary excipients or toxic ingredients).

The HPDI foundational supplement program is the result of many years of product formulation, evaluating scientific research, following the experience of end-users, feedback from doctors and other clients, and staying on the cutting-edge of nutritional science. HPDI is known for updating its formulas as new information becomes available regarding better forms of nutrients, or means form improving nutrient uptake or utilization.

HPDI FOUNDATIONAL SUPPLEMENTS

HPDI formulates four of the six types of formulas in the Foundational Supplements Program.

HPDI Multivitamins include: Hank & Brian’s Mighty Multi-Vite!, Multi Two (caps or tabs), Mini Multi (for the chemically sensitive), and the Kid’s Mighty Multi!

HPDI Vitamin C / Antioxidant formulas include: PRO-C, Ultimate Protector Nrf2 formula, Buffered C (tabs), and Buffered C (powder)

HPDI Essential Fatty Acids: Essential Fats Plus E

HPDI’s Rejuvenate! Superfoods include: Rejuvenate! Original (densely green), Rejuvenate! PLUS (lightly green), and Rejuvenate! Berries & Herbs (no greens). See the Rejuvenate! side-by-side comparison.

HPDI foundational supplements are formulated by Dr. Hank Liers, PhD. Hank is known for formulas that utilize only the highest-purity and highest-quality ingredients, and for his emphasis on natural forms (e.g., coenzyme forms) best recognized and utilized by the body.

FOUNDATIONAL SUPPLEMENTS ARE FUNDAMENTAL

Foundational supplements are the foundation for good health. That is why we call them foundational. This is also why we believe so strongly in providing a strong foundation of nutrients before recommending what we call enhancement formulas, specific-condition formulas, or other add-ons (such as a soil-based probiotic formula).

That is to say, a given individual will possibly have many requirements for nutrients specific to their needs. Such formulas may include magnesium, iodine, certain B vitamins like coenzyme folate (5-MTHF). An individual may also require formulas specific to certain issues, concerns, or organ systems, such as formulas targeting joint health, bone health, allergies, blood sugar, liver health, and others. In fact, HPDI formulates formulas specific to these needs.

Yet, before specific needs are addressed, or at least concurrently, HPDI believes that foundational nutrients must provide the base or foundation upon which all other nutrients, condition-specific formulas, or enhancement formulas rest.

One danger, as we saw with Joe’s supplement schedule before he started taking HPDI foundational supplements, was putting the cart before the horse. That is, finding a person in a situation where there are several or numerous advanced nutrients being taken. Yet, where the “base” is relatively weak due to low-potency supplements and/or lack of basic nutrients. In this type of situation, it is less likely that the addition of several advanced nutrients can make as much of a difference for health because key nutrients are missing.

Missing key nutrients prevents certain advanced nutrients or even higher levels of specific nutrients from doing their job because major imbalances can render those nutrients useless, less bioavailable, or unable to contribute what they could were there a sufficiency of the basic nutrients required to support all biochemical processes in the body. We have written much on this topic—please see the resources section (below) for more information.

The point is that without a plentiful supply of basic nutrients in ideal forms, which is exactly what is provided by foundational supplements (and almost never by diet alone), a person will remain vulnerable to many nutrient deficiencies. Nutrient deficiencies (especially when they are prolonged over time) can result in less than optimal health.

By simply providing optimal levels of all basic nutrients, foundational supplements support the body by covering its nutritional needs, not unlike insurance. Moreover, they are generally inexpensive (relative to conventional health care costs) even for the highest-quality supplements, such as HPDI formulas.

CONCLUSION

Foundational supplements remain fundamental for health. Nothing can replace them. Before starting single nutrients or condition-specific formulas, it is important to obtain a full complement of basic nutrients that support bodily function.

After basic nutrition is attained through foundational supplements, diet, and appropriate lifestyle changes, then other types of nutritional supplements (such as enhancement formulas and specific-condition formulas) may be added to form a complete nutritional supplement system.

Key Takeaways:

• More people are getting advanced forms of specific vitamins and minerals in supplement form, usually at the direction of their doctor or nutritionist

• Few people obtain a complete, high-potency multivitamin

• Fewer still consume high-quality forms of all basic nutrients (provided by good diet and foundational supplements)

• Adding a complete set of high-potency, foundational supplements (multivitamin, Vitamin C / antioxidant formula, essential fats, high-RNA superfoods), hydrogen, and gut health formulas) supports basic good health

• Poor dietary choices increase the need for nutritional supplements that can provide high levels of a wide range of essential nutrients

• Taking foundational supplements sporadically is not a good way to ensure you obtain adequate levels of the important nutrients you require daily

SOURCES & RESOURCES

Foundational Supplements Program

The Need for Foundational Supplements (.pdf)

HPDI BLOG ARTICLES

Amending the HPDI Foundational Supplements Program

Vitamin C / Antioxidants

PRO-C and Ultimate Protector – Comparison of Antioxidant Formulas

Questions and Answers about Ultimate Protector

The Amazing Healing Potential of Natural Nrf2 Activators

Ultimate Protector™: First Impressions

Ultimate Protector™ Brunswick Labs ORAC5.0™ Test Results

Preventing Free-Radical Damage Using Ultimate Protector™

Description and Comparison of ORAC Tests for Well Known Plant Ingredients and Ultimate Protector™

Ultimate Protector and the Role of Foundational Supplements for Health

Natural Phytochemical Nrf2 Activators for Chemoprevention

New Directions for Preventing Free Radical Damage

Ultimate Protector flyer (.pdf)

Review of Scientific Research on Oligomeric  Proanthocyanidins (OPC) by Dr. Hank Liers

Vitamin C – An Amazing Nutrient by Dr. Hank Liers

High-RNA Superfoods

Rejuvenate! Berries & Herbs: Ingredients for Optimal Nutrition

9 Things to Know About Rejuvenate!™ Superfoods

High-RNA Rejuvenate!™ Superfood

Rejuvenate! – The Original, High-RNA Superfood

Natural Phytochemical NRF2 Activators for Chemoprevention

DIETARY NUCLEIC ACIDS – DR. BENJAMIN S. FRANK, PART 1

DIETARY NUCLEIC ACIDS – DR. BENJAMIN S. FRANK, PART 2

Super-Tasty Morning Nutritional Drinks

PRODUCTS / SUPPLEMENTS

Hank & Brian’s Mighty Multi-Vite!

Multi Two (caps and tabs)

PRO-C (vitamin C / antioxidant formula)

Ultimate Protector™ Nrf2 Activator

Essential Fats Plus E

Rejuvenate!™ PLUS

Rejuvenate!™ (Original)

Rejuvenate!™ Berries & Herbs

Rejuvenate! Superfoods: Product Comparison

Hydrogen products

RESTORE

HPDI FOUNDATIONAL SUPPLEMENTS

Vitamin D3 PLUS

MYO-MAG (magnesium)

Warrior Sleep & Warrior products

Intestinal Rejuvenation Formula

Prescript-Assist probiotic (soil-based organisms)

CONTACT US:

You can reach HPDI by calling 1-800-228-4265, email Support(at)IntegratedHealth.com, or visit the retail website: IntegratedHealth.com

Health care professionals and resellers can apply for wholesale account, which includes access to the HPDI reseller website: HealthProductsDistributors.com. Email: Support(at)HealthProductsDistributors.com.

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EFFECTIVE PAIN RELIEF STRATEGIES WITH WARRIOR MIST

Fred Liers PhD warrior mist effective pain reliefI am excited this month to talk about Warrior Mist, which is an all-natural skin, muscle, and joint support formula. Warrior Mist is a topical formula that is my go-to-product for effective pain relief.

Warrior Mist is highly effective for pain. Indeed, my father Dr. Hank Liers formulated it for rapid pain relief, naturally. Many health care professionals find it useful for their clients.

Being applied topically on skin, Warrior Mist acts quickly at the pain source to stop it. Topical application is an advantage when it comes to rapid relief.

Warrior Mist topical effective pain relief

Warrior Mist comes in a pump-spray glass bottle.

NATURAL INGREDIENTS FOR EFFECTIVE PAIN RELIEF

Beyond its effectiveness against pain, what I like about Warrior Mist is that it contains all-natural ingredients. What does that mean? Most of its ingredients are herbal like peppermint oil, lavender oil, and organic coconut and olive oils.

Warrior Mist contains: DMSO (99.999% pure), peppermint oil (the source of menthol in the product), organic olive oil, distilled water, MSM, magnesium chloride, lemon oil, lavender oil, and organic coconut oil.

Warrior Mist contains no harsh chemicals or synthetic preservatives (like parabens, dimethicone, or phenoxyethanol). What else would you expect from a formulator like Dr. Hank Liers or a company like Health Products Distributors?

For anyone who cares about NOT putting toxic chemicals on their skin, Warrior Mist is a high-purity formula worthy of consideration. It is a pure, simple, and effective formula.

Warrior Mist comes in a spray bottle made of glass, not plastic. Shake it, then spray it. Gently massage the area of application to assist absorption. That’s all there is to it.

WARRIOR MIST APPLICATIONS FOR PAIN

Warrior Mist is effective for many applications, including pain relief for joints (wrists, elbows, knees, ankles), bruises and scratches, as well as insect bites and skin irritations. I occasionally I spray it directly into my mouth for throat relief, especially in winter or during allergy season (although technically it is not for internal use).

AIKIDO

I practice aikido, which can stress joints, especially wrists. Most aikido techniques involve grips that can become throws. There are also strikes, counterstrikes, blocks, falls, rolls, wrist breaks (escapes), and other movements.

Aikido is safe when practiced carefully. Yet, many techniques can lead to bumps, bruises, strains, sprains, and soreness. Warrior Mist helps me (and others) a lot. In fact, I donated a bottle of Warrior Mist to the dojo, so it’s there for anyone who needs it.

I am not sure what I would do for routine aches and pains without Warrior Mist. Sometimes just having relief after an aikido workout makes a big difference in my day.

My eight-year-old son also practices aikido in the same dojo. I feel confident using Warrior Mist on him because it is a safe, natural product that works.

I also practice yoga. Yoga rarely results in the types of minor injuries I experience from aikido. Yet, for times when I overstretch a muscle or overdo a pose, I reach for Warrior Mist for rapid, effective pain relief.

HIKING

I enjoy hiking. We live on the edge of a desert wilderness north of Tucson, Arizona. There are cactus, thick brush, thorny bushes, and biting insects like ants and scorpions. Many hikes involve at least a few thorns, scrapes, or mild soreness. Warrior Mist helps with these.

I have used Warrior Mist for bee and scorpion stings, ant bites, scrapes, cuts, small puncture wounds (e.g., from cactus spines), as well as skin irritations of various kinds.

In fact, there are few types of pain I have found Warrior Mist doesn’t mitigate. I use it for shoulder pain, neck pain, and lower back pain when it occurs. I notice the sooner I get Warrior Mist on the affected area, the faster I experience relief.

I don’t personally suffer from headaches, but friends who do tell me Warrior Mist helps them a lot. One of the ingredients is magnesium chloride, which is known to help ease headaches, including migraine headaches. Gently rub Warrior Mist around temples, forehead, or base of the neck.

Pain relief is not always immediate when using Warrior Mist. Yet, I know from experience how much it helps. The ingredients it contains support healing, too. Be patient, give it time, and allow it to work. That is exactly what I do sometimes.

AROUND HOUSE, YARD, AND GARDEN

Warrior Mist is ideal to keep in the house for everyday bumps and bruises like stubbed toes, bruised shins, or skinned knees. We find it useful after yardwork or gardening. You can spray it directly on an area, or else spray it into your hand first (after shaking the bottle), and then rub it into an affected area.

I know of two people who use Warrior Mist for pain in the tailbone (coccyx), the final segment of the vertebral column. Tailbone pain for them was originally caused by falling. One person fell from a horse and the other off a skateboard. While these injuries are structural, Warrior Mist provides significant relief. The reduction in pain helps daily function and facilitates sleep.

WARRIOR MIST FOR PETS

Warrior Mist is safe for use with pets. In fact, it was originally formulated for pets with the help of a veterinarian. You can feel confident using Warrior Mist on pets, large and small. It is ideal for use on dogs, cats, horses, and farm animals. Many veterinarians use Warrior Mist in their clinics for effective pain relief.

If you are a veterinarian, consider using Warrior Mist for your pet patients.

PROFESSIONAL USES

My wife Stefanie is a practicing acupuncturist. She uses and recommends Warrior Mist for her clients.

She frequently uses Warrior Mist in her practice for knee pain, shoulder pain, and back pain. What she often does is mix about five sprays (pumps) of Warrior Mist with about ten sprays of Magnesium Oil along with a dime-sized amount of carrier oil (like organic jojoba oil or coconut oil) in her palm.

She mixes the liquids in her palm (for amounts up to one tablespoon), but it can be mixed and stored a small container. For greater amounts, the ratios remain the same – about 2:1 Magnesium Oil to Warrior Mist – with correspondingly higher amounts of carrier oil. This is an excellent mixture because it combines the benefits of Warrior Mist and Magnesium Oil.

There is a slight chemical reaction that occurs when Warrior Mist mixes with Magnesium Oil. It is actually a warming effect. Stefanie likes it because the mixture is then applied warm, which relaxes muscles and opens pores for better absorption. No “warm up” is necessary and clients seem to appreciate the mixture’s warmth.

The mixture (of Warrior Mist, Magnesium Oil, and carrier oil) may be applied directly on affected areas with high rates of success. Clients themselves can obtain Warrior Mist and Magnesium Oil to make this mixture at home. Using a carrier oil is helpful, but not required because Warrior Mist contains organic coconut and olive oils.

Warrior Mist Magnesium Oil effective pain relief

Warrior Mist works well mixed with Ancient Minerals magnesium oil.

Stefanie also finds Warrior Mist useful for clients suffering from headaches. In addition, she will apply straight Warrior Mist to the throat, lymph nodes, or upper chest area for clients dealing with respiratory issues. Indeed, she applies it to these areas on herself when she feels she may be fighting or coming down with something.

Use Warrior Mist on clean, dry, lotion-free skin. The DMSO in the formula acts as a solvent carrying substances on skin into the body. This allows natural ingredients in the formula to penetrate into painful areas. Wash hands and the application area (or wipe with a damp cloth) before treatment. Avoid using carrier oils with toxic ingredients (like synthetic preservatives) that could be pulled into the body.

Stefanie tells her clients not to put anything on their skin that they would not eat. That is, use only natural oils and products containing ingredients that are natural and organic. A useful resource to determine what products are most natural is the Skin Deep Database on the Environmental Working Group website (www.ewg.org).

If you are a health care professional who deals with clients requiring pain relief, please contact HPDI to request a sample bottle of Warrior Mist. See how well this effective pain relief formula works for your clients.

Warrior Mist effective pain relief

Wash hands, shake bottle, then spray on clean, dry skin. Massage area to assist absorption.

WARRIOR MIST FOR ATHLETES AND SPORTS

One group of people who love Warrior Mist is athletes, especially runners, triathletes, and other endurance athletes. Warrior Mist is useful for nearly all sports, including contact sports.

HPDI’s sponsored athlete, pro cyclist Irena Ossola, uses Warrior Mist regularly, especially during races and high-intensity training. She incorporates it into the sports massage she receives with reportedly good effects. She also states that it helps her with recovery.

Irena occasionally crashes her bicycle. This remains a hazard in her sport, she says. However, Warrior Mist has done much to help her joints, road rash and other abrasions, sore muscles, and to speed her recovery.

For purposes of athletes, the magnesium chloride in Warrior Mist can help support muscle health and recovery, and provide effective pain relief.

WARRIOR MIST SUMMARY

Dr. Hank Liers designed Warrior Mist as a natural formula containing ingredients known for providing effective pain relief. Given its wide applicability, topical application, natural ingredients, and proven history of use, Warrior Mist is ideal for personal use by consumers and in clinical settings for clients who require effective pain relief.

Warrior Mist is one of the most natural, effective pain relief products available to heath care professionals and consumers alike.

Warrior Mist comes in a 30 ml (1 oz) spray bottle which provides hundreds of applications. A single bottle typically lasts about two months.

Directions: Shake bottle before applying. Wash hands before and after use. Apply in a thin layer to a clean, dry, and lotion-free area needing support. Shave thick hair that may prevent absorption by the skin. Gently massage the area of application to assist absorption. Re-apply as needed 3–4 times daily. (Contains DMSO, a known solvent.)

BEYOND WARRIOR MIST: WARRIOR SLEEP & WARRIOR ENERGY

Warrior Mist is one of three Warrior Health products offered by Health Products Distributors. Dr. Hank Liers formulated these Warrior products, all of which are topicals requiring ultra-low doses (ULD) by design: Warrior Mist, Warrior Sleep, and Warrior Energy.

Warrior Mist Sleep Roll-On Energy effective pain relief

Warrior Mist, Warrior Sleep, and Warrior Roll-On Energy are topical formulas.

Warrior Sleep (9 ml) is an effective, natural sleep and relaxation formula having no drug-like side effects (compared to conventional sleep aids). Like Warrior Mist, you apply Warrior Sleep directly to skin (transdermal application) for rapid absorption. Warrior Sleep incorporates four natural ingredients for sleep: lavender oil, roman chamomile, magnesium, and melatonin. It uses DMSO and natural oils to carry these rest promoters into the body. Warrior Sleep contains: DMSO (99.999% pure), olive oil, distilled water, MSM, magnesium oil, lavender oil, lecithin, roman chamomile oil, coconut oil, and melatonin.

Warrior Sleep

Warrior Sleep is an effective topical relaxation and sleep formula.

Warrior Roll-On Energy (9 ml) is a unique topical roll-on energy product. It is formulated to provide five hours of mental and physical enhancement. One bottle will last 30 days when used twice daily. Warrior Roll-On Energy contains: DMSO (99.999% pure), organic aloe vera gel (inner fillet), distilled water, organic extra virgin olive oil, peppermint oil, magnesium chloride with trace ocean minerals, MSM, organic coconut oil, caffeine (80% from green tea), soy lecithin (high phosphatide and 98% oil free), glutathione (reduced), Vitamin B6 (from pyridoxal-5’-phosphate), Vitamin B12 (as methylcobalamin), and Folinic Acid (from calcium folinate).

Warrior_Roll-On_Energy Warrior Sleep

Warrior Sleep and Warrior Roll-On Energy contain built-in roll-on applicators.

I use all three Warrior products depending on daily needs. Warrior Sleep is an effective sleep aid, but is also effective for relaxation or applied before bedtime to prepare for sleep. I apply to the neck base, upper throat, and temples. We have noticed it nourishes and smooths facial skin. This is due to its synergistic blend of ingredients, including melatonin, MSM, and organic carriers oils.

Warrior Roll-On Energy is uniquely energizing. It differs dramatically from most energy products, or coffee, tea, or chocolate. The formula utilizes ultra-low dose (ULD) technology to carry energizing ingredients (including caffeine from green tea) rapidly into the body. Yet, unlike caffeinated drinks, users typically experience no let down or rapid drop in energy after using it. Warrior Roll-On Energy provides non-jarring, sustained energy during the day (up to six hours).

Health Care Professionals: Please contact HPDI (1-800-228-4265) to request sample(s) of Warrior Mist, Warrior Sleep, Warrior Roll-On Energy, or other products in which you are interested.

RESOURCES

HPDI BLOG ARTICLES

Warrior Mist: Creating an Effective Pain Relief Formula

Super Remedies for Stings and Bites

PRODUCTS

Warrior Mist

Warrior Sleep

Warrior Roll-On Energy

Warrior Products

Magnesium Oil

CONTACT US:

You can reach HPDI by calling 1-800-228-4265, email support(at)IntegratedHealth.com, or visit the retail website: IntegratedHealth.com

Health care professionals and resellers can apply for wholesale account, which includes access to the HPDI reseller website: HealthProductsDistributors.com. Support(at)HealthProductsDistributors.com.

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WONDERS OF MOLECULAR HYDROGEN

Fred Liers PhD molecular hydrogen H2I drink hydrogen-infused water. You should, too. Why? Because the age of hydrogen is here. Molecular hydrogen, that is. We now know that molecular hydrogen has therapeutic potential for nearly every organ in the human body, as well as for 150 different human disease models! And it’s extremely safe.

MOLECULAR HYDROGEN: BACKGROUND

Molecular hydrogen, also known as “diatomic hydrogen,” is a colorless, tasteless, and odorless gas.

Elemental hydrogen (H) is the most abundant element in the universe constituting 75% of its mass. Yet, it is absent on earth in its monoatomic form, being present in water, and inorganic and organic compounds. Molecular hydrogen is found in the earth’s atmosphere at less than one part per million.

molecular hydrogen H2 water

Hydrogen-infused water is a simple means to consume molecular hydrogen.

The science regarding benefits to health of molecular hydrogen (H2) has advanced rapidly in recent years thanks to the pioneering efforts of research scientists around the globe.

Now hydrogen science is moving quickly beyond theory to practical applications. Moreover, new products exist allowing medical professionals and consumers to leverage the health benefits of hydrogen.

For decades, diatomic molecular hydrogen was generally considered an “inert” gas. That is perhaps the primary reason that molecular hydrogen has been recognized as a therapeutic molecule only recently.

Indeed, science has known about the health benefits of molecular hydrogen as early as 1798. Yet, as noted, for most of modern history the belief persisted that hydrogen was inert in the body. It was only in the late 20th century (ca. 1975) that it gained the attention of medical researchers, and only in the past 10 years has evidence for the health effects of molecular hydrogen gained critical mass in the scientific literature.

There are now more than 500 peer-reviewed articles demonstrating the therapeutic potential of hydrogen for nearly every organ in the human body, as well as in 150 different human disease models, according to the Molecular Hydrogen Foundation.

HEALTH BENEFITS OF MOLECULAR HYDROGEN (H2)

• Molecular hydrogen reduces oxidative stress as a selective antioxidant and by maintaining homeostatic levels of glutathione, superoxide dismutase, catalase,  and other free-radical scavenging nutrients.

• The antioxidant capacities of molecular hydrogen are such that it is beneficial for persistent and acute oxidative stress.

• Acute oxidative stress arises from a multitude of causes, including inflammation, cardiac or cerebral infarction, organ transplantation, heavy exercise, cessation of operative bleeding, and many other causes.

• Persistent oxidative stress relates to reactive oxygen species (ROS) generated in the body throughout life. For example, during exercise, exposure to pollutants and toxins or UV light, as well as physical and psychological stresses, and the aging process itself. As aerobic organisms, we generate ROS when breathing consumes oxygen.

• Molecular hydrogen is effective against hydroxyl radicals (OH). The hydroxyl radical is the radical species that causes much of the oxidative damage in the body. While vitamin C, glutathione, and certain plant-based antioxidants are somewhat effective against this radical, there is no Nrf2-induced enzyme that effectively quenches the hydroxl radical.

• This positions molecular hydrogen as a uniquely effective antioxidant against the hydroxyl radical. Notably, when molecular hydrogen quenches the hydroxyl radical, it produces water, which is non-toxic in the body.

• Beyond this, molecular hydrogen, like other gaseous signaling molecules such as NO, CO, H2S, appears to exhibit cell signal-modulating activity that confers it with anti-inflammatory, anti-obesity, anti-allergy, and many other benefits.

MOLECULAR HYDROGEN MEDICINE

The scientific literature discusses the use of molecular hydrogen for many clinical applications, including the following:

• METABOLIC SYNDROME including diabetes, hyperlipidemia, arteriosclerosis, hypertension, and obesity

• ISCHEMIA / REPERFUSION injuries including cerebral and myocardial infarctions, organ transplants, post-cardiac arrest

• NEUROPROTECTION including applications for dementia, Parkinson’s disease, depression, and anesthesia

• INFLAMMATION including applications for polymicrobial sepsis, rheumatoid arthritis, wound healing, and bowel diseases

• MITOCHONDRIAL DISEASES

• HEMODIALYSIS / VENTILATION

• AGING including cognitive decline

• EXERCISE including applications for fatigue, lactic acid, recovery, and oxidative stress related to heavy exercise

SIDE EFFECTS OF CANCER THERAPIES including radiotherapy and chemotherapy

• MANY OTHER BENEFITS

athlete molecular hydrogen performance race

Athletes benefit from molecular hydrogen. You can, too.

HOW MOLECULAR HYDROGEN WORKS

According to the Molecular Hydrogen Foundation, there are three ways molecular hydrogen exerts positive health effects.

1.  Molecular hydrogen easily diffuses into subcellular compartments where it scavenges cytotoxic oxygen radicals, thereby protecting DNA, RNA, and proteins against oxidative stress.

2.  Molecular hydrogen triggers activation or upregulation of additional antioxidant enzymes (e.g., glutathione, superoxide dismutase, catalase, and others) and/or cytoprotective proteins of the body.

3.  Molecular hydrogen may be a novel signaling molecule that alters cell signaling, cell metabolism, and gene expression. This may explain its apparent anti-inflammatory, anti-allergic, and anti-apoptotic (or anti-cell death) effects.

MOLECULAR HYDROGEN IS SAFE

Molecular hydrogen exhibits great safety, and it is regarded as safe for use in the body. It is shown no toxicity even in high concentrations.

Safety standards are already established for high concentrations of molecular hydrogen for inhalation because high-pressure H2 gas is used in deep-water diving gas mixtures to prevent decompression sickness.

Notably, H2 gas combusts only at temperatures higher than 527 °C, and it explodes by chain reaction with oxygen (O2) only in the range of Hconcentration (4–75%, vol/vol).

Molecular hydrogen can be used for medical applications safely by several ingestion methods including inhalation of 1–4% hydrogen gas, which exhibits great effectiveness.

All these factors mean that molecular hydrogen is safe, easy-to-use, and effective for therapeutic purposes.

molecular hydrogen H2 water

Hydrogen-infused water is safe, easy-to-consume, and cost effective.

USING MOLECULAR HYDROGEN

Methods for consuming molecular hydrogen include inhalation, oral ingestion of hydrogen-infused water, injection of hydrogen saline, and direct diffusion (eye drops, baths, cosmetics, etc.).

An advantage of inhaled H2 gas is that is acts rapidly. In this respect, may be suitable for defense against acute oxidative stress.

It has been shown that inhalation of 3–4% hydrogen (H2) gas reaches a plateau at approximately 10–20 μM in the arterial and venous blood in about 20 minutes. This is shown not to affect any physiological parameters (e.g., blood pressure), suggesting no adverse effects.

According to the Molecular Hydrogen Foundation, the consensus is that drinking H2-rich water is the easiest, and often the most effective, method for obtaining molecular hydrogen although it does not provide as many hydrogen molecules to the body as other methods.

Some studies show consuming H2-infused water to be more effective than inhalation or increasing intestinal H2 production via lactulose administration.

Another advantage of drinking hydrogen infused water is that it allows gastric induction of ghrelin, which is mediated via activation of beta 1 adrenergic receptors.

Above all, drinking hydrogen-infused water is easy to do, and convenient as you can drink it at home or while traveling.

HYDROGEN-INFUSED WATER

Inhalation of molecular hydrogen gas may be impractical for continuous H2 consumption in daily life. In contrast, solubilized H2 (hydrogen-infused water) is a portable, easily administered, and safe means to ingest H2.

H2 can be dissolved in water up to 0.8 mM (1.6 mg/L) under atmospheric pressure at room temperature without changing pH.

Hwater can be made by several methods: infusing H2 gas into water under pressure, electrolyzing water to producing H2, and reacting magnesium metal or its hydride with water.

Notably, H2 penetrates glass or plastic walls of vessels in a short time, yet aluminum containers retain hydrogen gas for a long time.

Water ionizers produce hydrogen gas via electrolysis. This method produces hydrogen concentrations from less than 0.05 ppm to more than 2.5 ppm. Typically 0.1 to 0.7 ppm hydrogen is produced, yet most companies manufacturing water ionizers neither know the concentration produced nor understand the significance of hydrogen for health.

In this regard, depending upon the production method much of the water containing molecular hydrogen exhibits a negative oxygen reduction potential (ORP). Yet, ORP is only a general indication of hydrogen production and is not a measurement of its concentration.

A second method of producing hydrogen-rich water by electrolysis is by infusion. In this method, hydrogen is directly infused into filtered water within a machine.

Another convenient method to generate molecular hydrogen is to add alkali-earth metals to water. Magnesium metal in commonly used for this purpose. This method allows for the production of high concentrations of molecular hydrogen that are generally near saturation (1.6 ppm), and therefore less water needs to be consumed by individuals drinking it.

Magnesium sticks and tablets/capsules are available (some of which are placed in water and others that can be consumed directly) that rapidly produce 2–4 ppm molecular hydrogen concentration. Like electrolysis, adding metals to water also increased the pH of water because they reduce the concentration of H+ ions.

Other methods exist that can produce supersaturated concentrations of molecular hydrogen with or without alteration of water pH. Advantages of these methods include having to drink a fraction of the amount of water in order to obtain an equal amount of molecular hydrogen.

Drinking water containing molecular hydrogen is probably the easiest and most cost-effective means for most persons to obtain hydrogen.

man drinks water infused with molecular hydrogen

Hydrogen-infused water can be consumed using tablets, prepared H2 beverages, or ionized water.

MOLECULAR HYDROGEN FROM YOUR MICROBIOME

Certain types bacteria in the intestinal tract produce hydrogen gas from non-digestible fibers, which may explain how fiber-rich diets reduce inflammation, and exert cardiovascular and other health benefits.

Diets low in dietary fiber from fruits and vegetables, or a decrease in microbiome diversity could potentially reduce production of molecular hydrogen. This could exert adverse effects on health.

The presence (or absence) of a diverse and robust microbiome may be one of the most significant factors in terms of how much hydrogen can be generated in the body. Most people today do not create the levels of molecular hydrogen in their digestive tracts that humans in earlier time periods generated largely because due to modern diets and less than optimal microbiome health.

Factors that influence or reduce microbiome health and diversity include antibiotic use, imbalanced diet, lack of certain fiber-rich vegetables in the diet, and consumption of herbicides, pesticides, and GMOs (that include glyphosate) that harm microbial populations and cause “leaky gut”.

As knowledge increases regarding ways we can support a healthy microbiome, the biological significance of hydrogen historically produced in our digestive tracts will be better understood.

BENEFIT TODAY FROM MOLECULAR HYDROGEN

The clinical applications of molecular hydrogen are impressive. One of the great advantages of molecular hydrogen infused water is that  it is easy to consume it, or make it in your own home or wherever you happen to be.

HPDI now sells a tablet hydrogen product from Purative known as Active H2.

Active H2 is a unique, patent-pending combination of all-natural minerals used to generate molecular hydrogen and electron-rich potential (-ORP). This distinguishes it from existing hydrogen formulas and electrolysis (water ionizers).

Active H2 is easy to use.  Simply place one tablet of in a 1/2 liter (16 oz) container of pure water (filled to the top) and close tightly. Wait at least 5–10 minutes for it to completely disintegrate (fizz), and then drink.

A one pint glass mason jar works well as a container for this purpose. However, you can use up to one liter (about 32 ounces) of water in a container, so a quart mason jar also works well. Consume the hydrogen-infused water ideally at least 30 minutes before food.

Active H2 formula consists of a proprietary blend of pure magnesium, malic acid, fumaric acid, and maltose that synergistically act to generate molecular hydrogen and electron-rich potential (-ORP).

Active H2 is the only all-natural add-in tablet providing molecular hydrogen in the amount of greater than 1.8 ppm, That is, one tablet typically generates molecular hydrogen in the concentration of about 2 ppm.

There are other molecular hydrogen products, including tablets, sticks, and pre-infused bottled products like H2Bev. H2Bev provides about 1.2–1.5 ppm of molecular hydrogen and comes in a 12 oz coated aluminum container for excellent H2 retention.

MOLECULAR HYDROGEN SUMMARY

Molecular hydrogen sits in the unique position of providing significant, wide-ranging benefits for health with an unmatched ease-of-use, and at relatively low cost for what it delivers.

We highly recommend the use of molecular hydrogen for its health benefits and for therapeutic applications. This includes the consumption of hydrogen-infused water whether from prepared H2 beverages, water ionizers, or highly effective Active H2 tablets.

Below we include important scientific abstracts you may find helpful in understanding the benefits and applications of molecular hydrogen.

 

SCIENTIFIC STUDIES ON MOLECULAR HYDROGEN

Beneficial biological effects and the underlying mechanisms of molecular hydrogen – comprehensive review of 321 original articles

From: http://www.ncbi.nlm.nih.gov/pubmed/26483953

Abstract
Therapeutic effects of molecular hydrogen for a wide range of disease models and human diseases have been investigated since 2007. A total of 321 original articles have been published from 2007 to June 2015. Most studies have been conducted in Japan, China, and the USA. About three-quarters of the articles show the effects in mice and rats. The number of clinical trials is increasing every year. In most diseases, the effect of hydrogen has been reported with hydrogen water or hydrogen gas, which was followed by confirmation of the effect with hydrogen-rich saline. Hydrogen water is mostly given ad libitum. Hydrogen gas of less than 4% is given by inhalation. The effects have been reported in essentially all organs covering 31 disease categories that can be subdivided into 166 disease models, human diseases, treatment-associated pathologies, and pathophysiological conditions of plants with a predominance of oxidative stress-mediated diseases and inflammatory diseases. Specific extinctions of hydroxyl radical and peroxynitrite were initially presented, but the radical-scavenging effect of hydrogen cannot be held solely accountable for its drastic effects. We and others have shown that the effects can be mediated by modulating activities and expressions of various molecules such as Lyn, ERK, p38, JNK, ASK1, Akt, GTP-Rac1, iNOS, Nox1, NF-κB p65, IκBα, STAT3, NFATc1, c-Fos, and ghrelin. Master regulator(s) that drive these modifications, however, remain to be elucidated and are currently being extensively investigated.

Molecular hydrogen as a preventive and therapeutic medical gas: initiation, development and potential of hydrogen medicine

From: http://www.ncbi.nlm.nih.gov/pubmed/24769081

Abstract
Molecular hydrogen (H2) has been accepted to be an inert and nonfunctional molecule in our body. We have turned this concept by demonstrating that H2 reacts with strong oxidants such as hydroxyl radical in cells, and proposed its potential for preventive and therapeutic applications. H2 has a number of advantages exhibiting extensive effects: H2 rapidly diffuses into tissues and cells, and it is mild enough neither to disturb metabolic redox reactions nor to affect signaling reactive oxygen species; therefore, there should be no or little adverse effects of H2. There are several methods to ingest or consume H2; inhaling H2 gas, drinking H2-dissolved water (H2-water), injecting H2-dissolved saline (H2-saline), taking an H2 bath, or dropping H2-saline into the eyes. The numerous publications on its biological and medical benefits revealed that H2 reduces oxidative stress not only by direct reactions with strong oxidants, but also indirectly by regulating various gene expressions. Moreover, by regulating the gene expressions, H2 functions as an anti-inflammatory and anti-apoptotic, and stimulates energy metabolism. In addition to growing evidence obtained by model animal experiments, extensive clinical examinations were performed or are under investigation. Since most drugs specifically act to their targets, H2 seems to differ from conventional pharmaceutical drugs. Owing to its great efficacy and lack of adverse effects, H2 has promising potential for clinical use against many diseases.

Molecular hydrogen in drinking water protects against neurodegenerative changes induced by traumatic brain injury.

From: http://www.ncbi.nlm.nih.gov/pubmed/25251220

Abstract
Traumatic brain injury (TBI) in its various forms has emerged as a major problem for modern society. Acute TBI can transform into a chronic condition and be a risk factor for neurodegenerative diseases such as Alzheimer’s and Parkinson’s diseases, probably through induction of oxidative stress and neuroinflammation. Here, we examined the ability of the antioxidant molecular hydrogen given in drinking water (molecular hydrogen water; mHW) to alter the acute changes induced by controlled cortical impact (CCI), a commonly used experimental model of TBI. We found that mHW reversed CCI-induced edema by about half, completely blocked pathological tau expression, accentuated an early increase seen in several cytokines but attenuated that increase by day 7, reversed changes seen in the protein levels of aquaporin-4, HIF-1, MMP-2, and MMP-9, but not for amyloid beta peptide 1-40 or 1-42. Treatment with mHW also reversed the increase seen 4 h after CCI in gene expression related to oxidation/carbohydrate metabolism, cytokine release, leukocyte or cell migration, cytokine transport, ATP and nucleotide binding. Finally, we found that mHW preserved or increased ATP levels and propose a new mechanism for mHW, that of ATP production through the Jagendorf reaction. These results show that molecular hydrogen given in drinking water reverses many of the sequelae of CCI and suggests that it could be an easily administered, highly effective treatment for TBI.

The evolution of molecular hydrogen: a noteworthy potential therapy with clinical significance

From: http://www.ncbi.nlm.nih.gov/pubmed/23680032

Abstract
Studies on molecular hydrogen have evolved tremendously from its humble beginnings and have continued to change throughout the years. Hydrogen is extremely unique since it has the capability to act at the cellular level. Hydrogen is qualified to cross the blood brain barrier, to enter the mitochondria, and even has the ability to translocate to the nucleus under certain conditions. Once in these ideal locations of the cell, previous studies have shown that hydrogen exerts antioxidant, anti-apoptotic, anti-inflammatory, and cytoprotective properties that are beneficial to the cell. Hydrogen is most commonly applied as a gas, water, saline, and can be applied in a variety of other mediums. There are also few side effects involving hydrogen, thus making hydrogen a perfect medical gas candidate for the convention of novel therapeutic strategies against cardiovascular, cerebrovascular, cancer, metabolic, and respiratory diseases and disorders. Although hydrogen appears to be faultless at times, there still are several deficiencies or snares that need to be investigated by future studies. This review article seeks to delve and comprehensively analyze the research and experiments that alludes to molecular hydrogen being a novel therapeutic treatment that medicine desperately needs.

Molecular hydrogen as an emerging therapeutic medical gas for neurodegenerative and other diseases

From: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377272/

Abstract
Effects of molecular hydrogen on various diseases have been documented for 63 disease models and human diseases in the past four and a half years. Most studies have been performed on rodents including two models of Parkinson’s disease and three models of Alzheimer’s disease. Prominent effects are observed especially in oxidative stress-mediated diseases including neonatal cerebral hypoxia; Parkinson’s disease; ischemia/reperfusion of spinal cord, heart, lung, liver, kidney, and intestine; transplantation of lung, heart, kidney, and intestine. Six human diseases have been studied to date: diabetes mellitus type 2, metabolic syndrome, hemodialysis, inflammatory and mitochondrial myopathies, brain stem infarction, and radiation-induced adverse effects. Two enigmas, however, remain to be solved. First, no dose-response effect is observed. Rodents and humans are able to take a small amount of hydrogen by drinking hydrogen-rich water, but marked effects are observed. Second, intestinal bacteria in humans and rodents produce a large amount of hydrogen, but an addition of a small amount of hydrogen exhibits marked effects. Further studies are required to elucidate molecular bases of prominent hydrogen effects and to determine the optimal frequency, amount, and method of hydrogen administration for each human disease.

Molecular hydrogen is a novel antioxidant to efficiently reduce oxidative stress with potential for the improvement of mitochondrial diseases

From: http://www.ncbi.nlm.nih.gov/pubmed/21621588

Abstract

BACKGROUND:
Mitochondria are the major source of oxidative stress. Acute oxidative stress causes serious damage to tissues, and persistent oxidative stress is one of the causes of many common diseases, cancer and the aging process; however, there has been little success in developing an effective antioxidant with no side effect. We have reported that molecular hydrogen has potential as an effective antioxidant for medical applications [Ohsawa et al., Nat. Med. 13 (2007) 688-694].

SCOPE OF REVIEW:
We review the recent progress toward therapeutic and preventive applications of hydrogen. Since we published the first paper in Nature Medicine, effects of hydrogen have been reported in more than 38 diseases, physiological states and clinical tests in leading biological/medical journals. Based on this cumulative knowledge, the beneficial biological effects of hydrogen have been confirmed. There are several ways to intake or consume hydrogen, including inhaling hydrogen gas, drinking hydrogen-dissolved water, taking a hydrogen bath, injecting hydrogen-dissolved saline, dropping hydrogen-dissolved saline into the eyes, and increasing the production of intestinal hydrogen by bacteria. Hydrogen has many advantages for therapeutic and preventive applications, and shows not only anti-oxidative stress effects, but also has various anti-inflammatory and anti-allergic effects. Preliminary clinical trials show that drinking hydrogen-dissolved water seems to improve the pathology of mitochondrial disorders.

MAJOR CONCLUSIONS:
Hydrogen has biological benefits toward preventive and therapeutic applications; however, the molecular mechanisms underlying the marked effects of small amounts of hydrogen remain elusive.

GENERAL SIGNIFICANCE:
Hydrogen is a novel antioxidant with great potential for actual medical applications. This article is part of a Special Issue entitled Biochemistry of Mitochondria.

Recent progress toward hydrogen medicine: potential of molecular hydrogen for preventive and therapeutic applications

From: http://www.ncbi.nlm.nih.gov/pubmed/21736547

Abstract
Persistent oxidative stress is one of the major causes of most lifestyle-related diseases, cancer and the aging process. Acute oxidative stress directly causes serious damage to tissues. Despite the clinical importance of oxidative damage, antioxidants have been of limited therapeutic success. We have proposed that molecular hydrogen (H(2)) has potential as a “novel” antioxidant in preventive and therapeutic applications [Ohsawa et al., Nat Med. 2007: 13; 688-94]. H(2) has a number of advantages as a potential antioxidant: H(2) rapidly diffuses into tissues and cells, and it is mild enough neither to disturb metabolic redox reactions nor to affect reactive oxygen species (ROS) that function in cell signaling, thereby, there should be little adverse effects of consuming H(2). There are several methods to ingest or consume H(2), including inhaling hydrogen gas, drinking H(2)-dissolved water (hydrogen water), taking a hydrogen bath, injecting H(2)- dissolved saline (hydrogen saline), dropping hydrogen saline onto the eye, and increasing the production of intestinal H(2) by bacteria. Since the publication of the first H(2) paper in Nature Medicine in 2007, the biological effects of H(2) have been confirmed by the publication of more than 38 diseases, physiological states and clinical tests in leading biological/medical journals, and several groups have started clinical examinations. Moreover, H(2) shows not only effects against oxidative stress, but also various anti-inflammatory and antiallergic effects. H(2) regulates various gene expressions and protein-phosphorylations, though the molecular mechanisms underlying the marked effects of very small amounts of H(2) remain elusive.

Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals

From: http://www.ncbi.nlm.nih.gov/pubmed/17486089

Abstract
Acute oxidative stress induced by ischemia-reperfusion or inflammation causes serious damage to tissues, and persistent oxidative stress is accepted as one of the causes of many common diseases including cancer. We show here that hydrogen (H(2)) has potential as an antioxidant in preventive and therapeutic applications. We induced acute oxidative stress in cultured cells by three independent methods. H(2) selectively reduced the hydroxyl radical, the most cytotoxic of reactive oxygen species (ROS), and effectively protected cells; however, H(2) did not react with other ROS, which possess physiological roles. We used an acute rat model in which oxidative stress damage was induced in the brain by focal ischemia and reperfusion. The inhalation of H(2) gas markedly suppressed brain injury by buffering the effects of oxidative stress. Thus H(2) can be used as an effective antioxidant therapy; owing to its ability to rapidly diffuse across membranes, it can reach and react with cytotoxic ROS and thus protect against oxidative damage.

ADDITIONAL RESOURCES

MOLECULAR HYDROGEN (H2) AT FOREFRONT OF HEALTH RESEARCH
by Hank Liers, PhD (from the HPDI blog)

ACTIVE H2 (tablet product)

Molecular Hydrogen Foundation (MHF)

Contact Us:

You can reach HPDI by calling 1-800-228-4265, email support(at)IntegratedHealth.com, or visit the retail website: www.IntegratedHealth.com

Health care professionals and retailers can apply for wholesale account, which includes access to the HPDI reseller website: www.HealthProductsDistributors.com