Prescript-Assist™ Broad Spectrum Probiotic & Prebiotic

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Fred Liers PhD prescript-assist probiotic prebioticHPDI has always offered high-quality probiotic formulas, such as Polydophilus. We are now very pleased to offer Prescript-Assist™, one of the very best broad spectrum probiotic and prebiotic formulas available.

Probiotics are valued for their capacities to improve health. They boost intestinal health by increasing populations of beneficial bacteria, counterbalance the adverse effects of antibiotics on gut flora, help fight yeast infections, and much more.

Current research shows that increasing population of “good-for-you” bacteria can exert beneficial effects beyond what anyone believed or predicted less than a decade ago. Some of these benefits are truly remarkable and the list of benefits seems to grow every year.


Benefits reported from probiotics include 1) relief of stress, anxiety, and depression, 2) mood improvement via gut-brain signaling, 3) protection against free radicals, 4) anti-inflammatory properties, 5) improvement of glucose tolerance, 6) reduction of upper respiratory tract infections, 7) allergy prevention, 8) cholesterol reduction, 9) beneficial effects in liver disease, and 10) many other health benefits.

It appears that the range of benefits of probiotics (including probiotic supplements) is so great and that more benefits (and their mechanisms) have yet to be discovered.

Benefits of Probiotics

People recognize that probiotics are found in a variety of foods with live or active bacteria cultures (often found in cultured or fermented foods), which include yogurt, sauerkraut, miso soup, buttermilk, and gouda cheese. Many traditional cultures emphasize the consumption of cultured foods.

Consuming cultured foods is a great way to obtain probiotics naturally from your diet. However, taking a probiotic supplement offers additional benefits beyond the benefits obtained from dietary sources. These benefits can include a wider range and greater number of beneficial bacteria, ease of use, standardized amounts to assess intake, and ensuring high intake of probiotics when dietary sources like cultured foods are not readily available or desirable.

Given the very broad range of benefits relating to use or consumption of probiotics, it is little wonder that they are so widely used, and so commonly recommended. Indeed, we recommend regular use of probiotic for a variety of health-related reasons. Our health recommendations often include the probiotic supplements we offer either as an “enhancement” supplement or sometimes as a “condition specific” formula depending on the health status of the individual and the conditions s/he seeks to address.

While cultured foods are often simply part of a traditional diet, people also consume these foods or take probiotics for specific reasons, such as when their gastrointestinal tract is not functioning well. Other times are when individuals experience GI related symptoms, including abdominal bloating or discomfort, indigestion, nausea, bowel irregularity, flatulence, as well as general malaise, fatigue, or weakness.

Because imbalances in the makeup of healthy bacteria found in the intestines can be the cause of health issues related to the digestive tract, it is important that if an individual decides to take a probiotic supplement that the supplement be of the highest quality and the greatest effectiveness.


Not long ago, HPDI decided to make Prescript-Assist™ available to our customers. We did this because we believe Prescript-Assist is hands down one of the best probiotic formulas available. Here are reasons that anyone who takes (or considers taking) probiotic supplements would benefit greatly from taking Prescript-Assist.


Prescript-Assist™ is a proprietary, broad spectrum formula providing 29 naturally resilient strains that support your body’s natural intestinal balance. Having so many strains means that this formula better reflects the great microbial diversity of the intestines vs typical probiotic products. In fact, more than 1,000 different species of microbes inhabit the human gut. Also of note: Prescript-Assist™ contains Bacillus subtilis, which is a well-proven probiotic species found in traditional foods.

Most probiotic formulas provide only lactic-acid based bacteria. Lactic-acid bacteria are important, but they are hardly the only or the most important probiotic for humans. They are also quite fragile, and must be refrigerated if they are to remain viable.

Here (below) is a complete list of the strains provided by Prescript-Assist. That is, each 600 mg capsule of Prescript-Assist includes the following microorganisms (and leonardite, a prebiotic):

Arthrobacter agilis, Arthrobacter citreus, Arthrobacter globiformis, Arthrobacter luteus, Arthrobacter simplex, Acinetobacter calcoaceticus, Azotobacter chroococcum, Azotobacter paspali, Azospirillum brasiliense, Azospirillum lipoferum, Bacillus brevis, Bacillus marcerans, Bacillus pumilus, Bacillus polymyxa, Bacillus subtilis, Bacteroides lipolyticum, Bacteriodes succinogenes, Brevibacterium lipolyticum, Brevibacterium stationis, Kurthia zopfii, Myrothecium verrucaria, Pseudomonas calcis, Pseudomonas dentrificans, Pseudomonas fluorescens, Pseudomonas glathei, Phanerochaete chrysosporium, Streptomyces fradiae, Streptomyces cellulosae, Streptomyces griseoflavus.

It is notable that science has discovered that the number of bacterial cells in our bodies is more than ten times the number of human cells. This collection of living cells is essentially an extension of our own bodies, and has been labeled the “human microbiome.”

It is clear that the number and types of species found in the gut can be a primary difference between an optimal digestive system and immune system, and those less than optimally functional. In scientific studies, individuals exhibiting higher levels of gastrointestinal distress and gut irregularities have been found to have a correspondingly lower variety of beneficial bacteria in the intestines.


Prescript-Assist™ is a next-generation, clinically proven probiotic supplement designed to to ensure maximum viability of the many organisms it provides. The formula offers inherent viability because the species it provides naturally adapted for survival in the human GI tract. That is, these 29 species are environmentally based (SBO) species drawn from the terrestrial microbiome where they have prospered and adapted for millenia to beneficially coexist with humans.

This inherent viability avoids the need for nano-encapsulation or hard-shelled enteric-coated capsules, which both are essentially attempts to force viability of probiotic species rather than utilizing hardy strains that are naturally pre-adapted to our bodies.

Thus, typical probiotic formulas contain low viability lactic acid bacteria that must be protected by technologies such as micro-encapsulation due to their inherent fragility. These fragile bacteria have a difficult time surviving because they are readily destroyed within the acidic environment of the stomach. While patented enteric coatings can help survival rates, the provision of high-viabiltiy organisms that reach the intestines intact due to the inherent strength of their natural spore structure makes more sense as a means to protect against degradation in the stomach and intestinal tract.

Bottom line: Prescript-Assist™ provides bacteria that reach the intestines intact due to the fact that the spore structure protects against degradation or destruction by stomach acids.


Prescript-Assist offers unparalleled shelf stability. It is well known that conventional probiotics (i.e., lactic acid bacteria) are readily damaged, degraded, and destroyed by the heat and pressure of the manufacturing process. They are also degraded by exposure to light and by temperature changes. Because they lack shelf stability, if they are not kept refrigerated, they often cannot provide a sufficient quantity of organisms by the time of ingestion.

In contrast, Prescript-Assist features probiotic bacteria protected by a durable seed-like structure, so that they are better safeguarded against environmental factors, including heat, pressure, light, or temperature variability. Indeed, testing confirms that the probiotic bacteria in Prescript-Assist remain 95% viable two years after their date of manufacture without any need for refrigeration.


Most probiotic formulas do not contain any prebiotics, which are a food source for bacteria, and help accelerate their growth. Prescript-Assist uniquely contains leonardite, which is a prebiotic mixture of humic and fulvic acids, which allows the beneficial bacteria to proliferate and thrive.


Probiotic supplement formulas typically do not offer product-specific clinical studies validating their effectiveness. Prescript-Assist™ is different. It is supported by a peer-reviewed, placebo-controlled human clinical trial, and a one-year follow-up study that verifies its long-term efficacy.

Below is a summary of major features and benefits provided by Prescript-Assist™.

Why is Prescript-Assist a better choice?

  • No Need for Refrigeration.
  • Backed by Sound Science: Supported by peer-reviewed, published clinical studies.
  • Inherent Organism Viability: A matrix of superior, highly resilient microflora whose organic, seed-like structures survive the early GI tract to thrive in the intestines.
  • Contains Bacillus subtilis:  A proven probiotic species found in traditional foods.
  • 29 Symbiotic Organisms: A balanced formulation specially selected to mimic the natural flora found in traditional and paleolithic diets.
  • Proven Shelf Stable:  With variations of less than 5% over two years from date of manufacture when stored at 98°F / 37°C .
  • Supported By Prebiotics. 
  • Gluten-Free, Dairy Free, and Vegan.


As a dietary supplement for adults, take 1–2 capsules per day, or as directed by your health care professional. May be taken with or without food.


No refrigeration necessary. Store under normal conditions.

Shelf Life:

Routine viability testing confirms greater than 95% viability two years after date of manufacture — without refrigeration. See individual package for expiry.


We at HPDI have always striven to bring our customers the best products and formulas available whether or not we ourselves design and produce them.

When a formula like Prescript-Assist™ comes along (which is not every day), we are often quick to recognize its benefits, which in this case are many. We offer this unique formula knowing that it is safe, effective, and can help improve the health of our customers.

We also know that Prescript-Assist can be used effectively in combination with our other supplements (i.e., foundational supplements and superfoods), including formulas we design specifically for GI health like Intestinal Rejuvenation Formula.

Indeed, we ourselves take Prescript-Assist™ and experience major health benefits. In addition, we personally witness and hear from many individuals who take the formula based on our recommendations. The results reported are excellent.


Intestinal Rejuvenation Formula


“A New View of the Role of Bacteria in Health” – by Dr. Hank Liers – from the HPDI Blog

“Probiotics Shown to Improve Mood Naturally, Alleviate Stress”

“2 More Reasons You Should be Taking Probiotics”

“Prescript-Assist Probiotic-Prebiotic Treatment for Irritable Bowel Syndrome: A Methodologically Oriented, 2-Week, Randomized, Placebo-Controlled, Double-Blind Clinical Study”

“Prescript-Assist Probiotic-Prebiotic Treatment for Irritable Bowel Syndrome: An Open-label, Partially Controlled, 1-year Extension of a Previously Published Controlled Clinical Trial”

Messaoudi, M, et al. Beneficial psychological effects of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in healthy human volunteers. Gut MicrobesJuly/August 2011; 2:4, 256-261.

Sudo N, Chida Y, Aiba Y, Sonoda J, Oyama N, Yu XN, et al. Postnatal microbial colonization programs the hypothalamic-pitutary-adrenal system for stress response in mice. J Physiol 2004; 558:263-75.

Sudo N. Stress and gut microbiota: does postnatal microbial colonization programs the hypothalamicpituitary- adrenal system for stress response? Int Congr Ser 2006; 1,287:350-4.

Messaoudi M, et al. Assessment of psychotropic-like properties of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in rats and human subjects. Br J Nutr 2011; 105:755–64.

Martarelli, D et al. Effect of a probiotics intake on oxidant and antioxidant parameters in plasma of athletes during intense exercise training. Curr Microbiol. 2011 June; 62(6): 1689–96.

Gleeson, M et al. Daily probiotic’s (Lactobacillus casei Shirota) reduction of infection incidence in athletes. Int J Sport Nutr Exercise Metab. 2011;21:55–64.

Fred Liers, PhD

Fred Liers, PhD

Fred Liers, PhD is Communications Director for Health Products Distributors, Inc. (HPDI). He leads public relations, education, outreach, and marketing efforts. In addition, he writes for HPDI's website (www.IntegratedHealth.com) and blog (www.IntegratedHealthBlog.com), as well as supports HPDI's design of advanced nutritional supplement formulas.

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