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MAXIMIZING HYDROGEN SUPPLEMENTS—MEGAHYDRATE AND ACTIVE H2 ULTRA—WITH pH ADJUST ALKALINIZING FORMULA

Fred Liers PhD pH adjust hydrogen supplementsToday, I talk about hydrogen supplements with a twist. Specifically, I discovered that a unique combination of three products—MegahydrateActive H2 Ultra, and pH ADJUST Alkalinizing Formula—provides surprising benefits. I put this combination, or concoction, into water to produce a hydrogen-infused drink with potent antioxidant quenching capacity that also rapidly alkalinizes the body (increasing pH levels and buffering acids), and provides the important minerals potassium and magnesium.

Combining hydrogen supplements with pH ADJUST creates a hydrogen-infused drink giving you benefits from 1) Two types of hydrogen, hydride (H-) and molecular hydrogen (H2) with antioxidant and energizing properties, 2) Increased pH levels (greater alkalinity) to balance pH levels, 3) Bicarbonates helping buffer acids and replenish bicarbonate reserves in the body, and 4) Essential minerals (potassium, magnesium) in bio-available forms.

In practical terms, this drink is energizing, anti-aging (party due to free-radical quenching effects), hydrating, and powerfully alkaline-forming! What this means for you might be a revolutionary drink that by giving your body all the antioxidant benefits of hydrogen plus increasing your pH levels turns can significantly improve multiple aspects of health.

By buffering acidity and making you alkaline, this drink can improve things like the strength of bones and teeth (via buffering and remineralization), supports kidney health (as kidneys are responsible for your bicarbonate reserves), boosts oxygenation (and thereby supports easier breathing) because alkaline cells hold more oxygen, and stops or reduces acid indigestion, acid reflux, and other acid-related problems. That could be just the beginning of the benefits you might receive because increasing your pH levels and normalizing alkaline conditions (i.e., pH 7.35–7.45) positively impacts many systems in the body.

WHY COMBINE pH ADJUST AND HYDROGEN SUPPLEMENTS?

pH Adjust, Megahydrate, and Active H2 Ultra are good supplements when used by themselves. That is, they work well as stand alone supplements. But I have found the combination of all three offers maximum antioxidant, alkalization, buffering, and mineralization benefits.

pH Adjust maximizes the effects of hydrogen supplements by boosting alkalinity and buffering capacity through the inclusion of effective, natural forms of important minerals and bicarbonates, including: potassium bicarbonate, magnesium carbonate, potassium glycinate, and sodium bicarbonate.

SYNERGY: HOW EACH PRODUCT CONTRIBUTES TO THE DRINK

There are potent synergistic effects to the combination of all three products. In particular, using both hydrogen negative ions (H-) or hydride and molecular hydrogen (H2) creates cascade effects in which hydrogen ions “recycle” themselves as antioxidants. The addition of pH Adjust brings its own set of benefits.

MEGAHYDRATE provides hydride or hydrogen negative ions (H-), also known as anions, that act significantly as antioxidants. These hydrogen ions can last up to three weeks in water. In the body, after the H- has donated its electron, it becomes simply “H” and proceeds to pair with another hydrogen atom to form H2 (molecular hydrogen), thereby continuing to exert free-radical quenching action. This is a major benefit of consuming H- in the quantities provided by Megahydrate.

ACTIVE H2 ULTRA provides molecular hydrogen (H2) directly into the body in significant amounts. Molecular hydrogen offers many benefits to the body, especially antioxidant benefits. Being an extremely small molecule, molecular hydrogen can enter into the smallest cellular compartments, including the nucleus of the cell, a place where most antioxidants are too large to enter) where it can exert its antioxidant capabilities. Molecular hydrogen actually provides a wide range of health benefits. (See the Molecular Hydrogen Institute (MHI) website for more information.)

pH ADJUST Alkalinizing Formula provides effective alkalinizing and buffering functions, as well as minerals (like potassium and magnesium) and bicarbonates needed for health. It is a fluffy, white powder that mixes easily in water, teas, coffee, and other liquids. It is formulated to rapidly increase pH levels, and acts as a buffering agent to balance pH in the body.

pH Adjust was created by my father, Dr. Hank Liers, HPDI’s founder and formulator of all “Dr. Liers Original” supplements. Dr. Hank been designing effective nutritional supplements since before 1988, the year he founded HPDI.

ph adjust hydrogen supplements active h2 ultra

ACID-BASE BALANCE CRITICAL FOR HEALTH

Acid-base balance is critical in the body, where a pH level of 7.35–7.45 must be maintained. Modern diets and lifestyles tend to be acidifying for the body. Diets high in animal foods that are not adequately balanced with vegetable foods lead to acidity. Other factors include overconsumption of grains, alcohol, and other acid-forming foods. Stress can also play a role due too the acidifying effects of stress hormones like cortisol.

Moreover, the aging process itself depletes bicarbonate reserves. As noted, pH Adjust contains bicarbonates that help replenish bicarbonate reserves necessary for buffering acids. Finally, a significant portion of the population has low intake of potassium and magnesium, which pH Adjust includes as part of its design.

pH Adjust also includes sodium bicarbonate (baking soda), which is a well known acidity buffer and alkalinizer. For users, advantages of pH Adjust over pure sodium bicarbonate include reduced sodium intake, improved taste, and the provision of potassium and magnesium.

POTASSIUM & MAGNESIUM FOR HEALTH

Potassium is critical in the body not only for alkalinity, but also for its role in the sodium-potassium pump which is important in the production of cellular energy (ATP) and for preventing too high levels of sodium from entering cells.

Magnesium is essential in the body and plays a role in wide range of functions, including cellular energy production, immune function, muscle and connective tissue health, and more than 400 enzyme reactions.

pH ADJUST is a highly effective buffering formula, which tends to bring pH levels (low or high) back into the optimal range (7.35-7.45). This buffering capacity means users can both avoid acidosis (high acidity) and alkalosis (high alkalinity).

MAKE THE DRINK

OPTIMIZE MEGAHYDRATE & ACTIVE H2 ULTRA BY ADDING pH ADJUST

Start with 8–16 ounces of fresh, purified water. Add 1–2 scoops of pH ADJUST, 1–2 capsules (or 1-2 scoops) of MEGAHYDRATE, and 1–2 ACTIVE H2 ULTRA tablets. Add the Active H2 Ultra tablets last, and let them effervesce completely (about 1 minute) before drinking.

This alkaline-forming, hydrogen-infused water is best taken on an empty stomach. It is ideal to drink in the morning or the afternoon (away from food). Allow at least 15–30 minutes before eating, or see what works for you. I sometimes eat light foods 10 minutes after taking this drink.

I recommend testing your pH levels (salivary and/or urinary) using pH test paper (litmus paper). pH test paper gives you a way to accurately track your pH levels. You can also use it to measure the pH of foods you consume, such as hydrogen-infused water and drinks containing pH Adjust.

Note: Many HPDI customers use pH Adjust in other drinks, including tea, coffee, and ketogenic coffee. Coffee can be acidic and acid-forming beverage, so adding pH Adjust helps buffer the acidity. Many users say pH Adjust tastes mild or good in coffee, and some say it adds a certain creaminess to it.

USE THIS ALKALINIZING HYDROGEN DRINK!

The only way you will know how beneficial hydrogen-infused water with pH Adjust can be—or how well it works for you—is to make it and use it! You will likely find yourself surprised by how energizing, alkalinizing, and mineralizing it truly is for you. And how good you feel when you drink it!

Consider testing the pH of your water first using pH test paper. Many people drink highly acidic water (pH 6 or less) without realizing it. Just because your water is filtered or purified does not necessarily mean it is alkaline. pH Adjust can “fix” this problem. Other people report that their water is highly alkaline (8.0+). Either way, pH Adjust can buffer the water to put it into the range slightly alkaline range of about 7.35–7.45. If you have extremely acidic water, you might need to use two servings of pH Adjust in 8–16 ounces of water. Play with it.

Let us know how this works out for you. We welcome your feedback and success stories!

MANY OTHER WAYS TO USE pH ADJUST

Hydrogen supplements and pH Adjust are made for each other, and create wonderfully alkalinizing hydrogen-infused water. But there are other ways to use pH Adjust. As I mentioned, you might like to read about making pH Adjust Coffee or Ketogenic Coffee using pH Adjust. Or watch my videos below. Also, did you know you can use pH Adjust in lemonade and other juices?

MY YOUTUBE VIDEOS

pH ADJUST COFFEE: https://youtu.be/72fAz9ob3bo
“How to use pH Adjust Alkalinizing Formula in Coffee”

KETOGENIC COFFEE VIDEO: https://youtu.be/yzyVbFD_JVA
“How to Make Keto Coffee with pH Adjust – Alkalinizing Coffee”

HOW TO USE PH ADJUST ALKALINIZING FORMULA: https://youtu.be/kuP2BuvMSXA

HOW TO MAKE LEMONADE AND USE pH ADJUST: https://youtu.be/deF7BZcFtEs

HYDROGEN SUPPLEMENTS IN DEPTH: ACTIVE H2 ULTRA and MEGAHYDRATE: https://youtu.be/gwFLv6M4uMo

PRODUCTS: pH ADJUST AND HYDROGEN

pH Adjust, Megahydrate, and Active H2 Ultra are available from Health Products Distributors, Inc. (HPDI):

pH ADJUST: http://www.integratedhealth.com/ph-adjust.html

MEGAHYDRATE: http://www.integratedhealth.com/megahydrate-60-caps.html

ACTIVE H2 ULTRA: http://www.integratedhealth.com/hydrogen-tablets.html

PH TEST PAPER (Hydrion brand): http://www.integratedhealth.com/ph-paper.html

HPDI RESOURCES

HPDI WEBSITE: http://www.IntegratedHealth.com
RESELLER SITE: http://www.HealthProductsDistributors.com

HPDI BLOG: http://www.integratedhealthblog.com
RESELLER BLOG: http://www.healthproductsdistributors.com/blog (a blog just for HPDI resellers)

HPDI NEWSLETTER: http://www.integratedhealth.com/newsletter.html

HPDI OFFICE (Oracle, AZ): 1-800-228-4265 (M-F 8–3:45 pm Arizona Time)

FACEBOOK: https://www.facebook.com/healthproductsdistributors
FACEBOOK GROUP (Creating Health Naturally): https://www.facebook.com/groups/creatinghealthnaturally

TWITTER: http://www.twitter.com/HPDIHealth

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REJUVENATE! BERRIES & HERBS – SUPERFOOD FORMULA UPDATED

Dr. Hank Liers, PhD Rejuvenate! Berries & Herbs superfoodToday I talk about my REJUVENATE!™ BERRIES & HERBS high-RNA superfood. I designed it to be a super-delicious, intensely berry flavored superfood with no greens. I put in real organic berries—BLUEBERRY, STRAWBERRY, RASPBERRY, and CRANBERRY—so it bursts with true berry flavors! I recently updated the formula, so it is is more delicious and nutritious than ever.

REJUVENATE! BERRIES & HERBS – A COMPLETE SUPERFOOD

Rejuvenate! Berries & Herbs is a delicious high-RNA (390 mg), high-protein (14.6 g) (organic pea and organic rice), high-antioxidant (ORAC value of 14,000+), high fiber (13 g) superfood with a creamy smoothness and rich berry flavor that tastes beyond great! It also boosts health with a complete multivitamin-multimineral sub-formula and important cell-protective herbs (herbal complex) that includes ginger, dandelion, burdock, turmeric, green tea extract, astragalus, and many other health-building herbs.

How to use Rejuvenate! Berries & Herbs? Just mix in water, juices, nut milks, or smoothies to create a drink with superb health benefits. Or use it creatively in foods, such as nut butters, salads, fruits, sauce/dressings, or desserts. It tastes so good, some people like to eat it by itself—or mixed in a little purified water.

rejuvenate berries herbs

HEALTHY AND HIGH-RNA BY DESIGN

Rejuvenate! Berries & Herbs is among HPDI’s premier high-RNA superfoods. That is, Rejuvenate! Berries & Herbs is one of three Rejuvenate! superfoods, which are the world’s first—and only—dedicated high-RNA superfoods. High-RNA nutrition means high in dietary nucleic acids, which Dr. Benjamin S. Frank considers to be essential nutrients, like vitamins and minerals (Dietary Nucleic Acid Nutrition & Therapy). Dr. Frank’s studies demonstrate many benefits of nucleic acids, including: greater energy, endurance, functional strength, easier breathing (anti-anoxic effect), as well as cardiovascular benefits and cosmetic benefits (smoother skin and a more youthful appearance).

Highlights of Rejuvenate! Berries & Herbs:

• Delicious Berry Flavor Bursts with Real Organic Berries!
• Powerful Organic and Wildcrafted Cell-Protective Herbs
• High ORAC Value (~14,270 units)
• 390 mg Dietary Nucleic Acids (RNA/DNA) from Vegetarian Sources
• Multiple Prebiotics Supporting your Microbiome
• Gluten Free, Vegan/Vegetarian, No Artificial Ingredients
• Mixes Well with other Rejuvenate!™ Superfoods

My updated formula (as of 12/2018) features, per serving:

– 2.6 g more protein (14.6 g total)
– Very little sugar (1.2 g total)
– 7.0 g more fiber (13 g total)
– 100 mg of organic BiAloe® aloe vera gel powder with over 18% acemannan
– 700 mcg of folate as 5-MTHF (natural, coenzyme folate)
– A smooth & delicious taste (even better than before!)

Given all the upgrades I recently made to the formula, I certainly hope you will give it a try. I’m so happy with it, and I use it daily. Berries & Herbs hardly feels (or tastes!) like a nutritional supplement. But believe me, there are few superfoods anywhere that provide as much nutrition—or nutrient density!

HIGHEST QUALITY INGREDIENTS – INCLUDING ORGANIC AND WILDCRAFTED

To give you a better idea of the high-quality ingredients I put into Rejuvenate! Berries & Herbs, check out this complete list of ingredients:

INGREDIENTS: REJUVENATE! BERRIES & HERBS contains: pea protein*, rice protein*, flax seed powder*, rice bran solubles, d-ribose, cranberry powder*, blueberry powder*, raspberry powder*, strawberry powder*, nutritional yeast, sunflower lecithin, inulin (from chicory root), broccoli sprouts powder*, mannitol, xylitol* (from hardwood), magnesium malate, VitaBerry® Plus† (from freeze dried wild blueberry, cranberry, raspberry, strawberry, prune, cherry, wild bilberry, whole grape powders, resveratrol, and quercetin), l-lysine hydrochloride, mixed berry flavoring* (on gum acacia), vanilla flavoring* (on gum acacia), RNA (from yeast), magnesium ascorbate, chlorella growth factor (CGF), burdock root powder*, astragalus powder*, turmeric root powder*, ginger root powder*, digestive multienzyme complex, choline bitartrate, malic acid, dulse*, kelp*, aloe vera* (BiAloe® concentrate), n-acetyl-l-cysteine, rutin, milk thistle extract, green tea extract, licorice root powder*, dandelion root powder*, rhodolia extract, inositol, biotin, stevia leaf extract, alpha lipoic acid, d-alpha tocopheryl succinate, niacinamide (Vit. B3), whole grape extract, high-gamma mixed tocopherols, phylloquinone (Vit. K1), immune assist mushroom extract, pantothenic acid, resveratrol, methylcobalamin (Vit. B12), pyridoxal-5’-phospate (Vit. B6), thiamin diphosphate (Vit. B1), riboflavin-5’-phosphate (Vit. B2), l-selenomethionone, cholecalciferol (Vit. D3), and calcium L-5-methyltetrahydrofolate.

*Organic ingredient
†VitaBerry Plus® is a registered trademark of VDF Futureceuticals, Inc.

Rejuvenate berries and herbs nutrition facts table

Rejuvenate! Berries & Herbs is available from Health Products Distributors, Inc.:

Try Rejuvenate! Berries & Herbs  (organic and wildcrafted berries & herbs)

You may also like: Rejuvenate! PLUS (light, sweet green superfood)

There are three Rejuvenate! superfoods. Which one is best for you? See our Rejuvenate!™ comparison page.

BLOG ARTICLE:

TASTY SMOOTHIE WITH REJUVENATE! BERRIES & HERBS by Fred Liers

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TASTY SMOOTHIE WITH REJUVENATE! BERRIES & HERBS

Fred Liers PhD rejuvenate! berries & herbsToday I make a tasty smoothie with the new, improved REJUVENATE!™ BERRIES & HERBS superfood. In fact, Rejuvenate! Berries & Herbs is likely the most delicious among HPDI’s Rejuvenate! superfoods, as it contains for types of real organic berries: Blueberries, Strawberries, Raspberries, and Cranberries. This uber-berry superfood was born for smoothies.

Rejuvenate! Berries & Herbs is a uniquely healthy superfood that not only tastes amazingly good, but its high berry content gives it an ultra-high antioxidant value (ORAC) of 14,270 units per serving—an exceedingly high ORAC value compared to typical “superfood” formulas.

Rejuvenate! Berries & Herbs provides 14.6 gm of organic protein (including organic pea and organic rice). It includes a potent cell-protective herbal complex (including green tea extract, ginger, turmeric, astragalus, burdock, dandelion, and rhodiola). In addition, it contains a built-in multivitamin sub-formula including coenzyme vitamins and other highly assimilable forms of important micronutrients.

I especially love Rejuvenate! Berries & Herbs because my father Dr. Hank Liers formulated it to provide the most dietary nucleic acids per serving—390 mg (dietary RNA/DNA)—the most per serving in any Rejuvenate! superfood. Sources of dietary nucleic acids in Rejuvenate! Berries & Herbs include nutritional yeast, yeast extracts, and CGF (chlorella growth factor).

Dietary nucleic acids are proven to provide significant benefits for health. Studies by pioneering nucleic acid researcher Benjamin S. Frank, MD, PhD indicate effects such as greater endurance, easier breathing (anti-anoxic effect), increased energy (ATP production), improved functional strength, warmer body temperature (e.g., cold resistance), and other effects. Dr. Frank asserts that dietary nucleic acids are essential nutrients, not unlike vitamins and minerals (Dietary Nucleic Acid Nutrition & Therapy).

rejuvenate berries & herbs

Considering all the benefits conferred by dietary nucleic acids, you really cannot go wrong by consuming more of them daily. And Rejuvenate! Berries & Herbs helps you do that by providing nearly 400 mg of dietary RNA/DNA per serving. That is a therapeutic dose which means you stand to gain all the benefits they confer. Depending on who you are and your health status, that could mean a lot in terms of helping you be healthier.

In sum, Rejuvenate! Berries & Herbs uniquely offers: 1) High RNA (dietary nucleic acids), 2) High Antioxidant Levels, 3) Herbal Sub-Formula, 4) High Protein, 5) Built-in Multivitamin, and 6) SUPER TASTE—that is super delicious in your superfood smoothies.

You just cannot get all these benefits in ANY other superfood, including other Rejuvenate! superfoods, each of which is formulated with a specific purpose. For example, Rejuvenate! PLUS is designed to provide significant levels of greens (think chlorella and spirulina), but lacks berries. Within its berry bailiwick, Rejuvenate! Berries & Herbs truly stands alone as one-of-a-kind.

REJUVENATE! BERRIES & HERBS highlights:

• Delicious Berry Flavor Bursts with Real Organic Berries (blueberries, strawberries, raspberries, cranberries)!
• Powerful Organic and Wildcrafted Cell-Protective Herbs
• High Antioxidant (ORAC) Value of 14,270 units per serving!
• Contains Multiple Prebiotics Supporting Your Microbiome
• Suitable for Vegetarians and Vegans & Gluten Free
• Mixes Well with other Rejuvenate!™ superfoods (like Rejuvenate! PLUS and Rejuvenate! Original Greens) and smoothie ingredients.

New, improved REJUVENATE! Berries & Herbs features (per serving):
• 14.6 g protein
• Very little sugar (1.2 g total)
• 7.0 g more fiber (13 g total)
• 100 mg of organic BiAloe® aloe vera gel powder with over 18% acemannan
• 700 mcg of folate as 5-MTHF
• Smooth texture & delicious taste!

There you have it. If you’re anything like me—and you love the taste of real, organic berries—consider Rejuvenate! Berries & Herbs to be your greatest ally when it comes it to tasty and healthy superfood nutrition. Make yourself a Berries & Herbs smoothie, and start creating health naturally today! ~

REJUVENATE! BERRIES & HERBS DETAILS

INGREDIENTS: REJUVENATE! BERRIES & HERBS contains: pea protein*, rice protein*, flax seed powder*, rice bran solubles, d-ribose, cranberry powder*, blueberry powder*, raspberry powder*, strawberry powder*, nutritional yeast, sunflower lecithin, inulin (from chicory root), broccoli sprouts powder*, mannitol, xylitol* (from hardwood), magnesium malate, VitaBerry® Plus† (from freeze dried wild blueberry, cranberry, raspberry, strawberry, prune, cherry, wild bilberry, whole grape powders, resveratrol, and quercetin), l-lysine hydrochloride, mixed berry flavoring* (on gum acacia), vanilla flavoring* (on gum acacia), RNA (from yeast), magnesium ascorbate, chlorella growth factor (CGF), burdock root powder*, astragalus powder*, turmeric root powder*, ginger root powder*, digestive multienzyme complex, choline bitartrate, malic acid, dulse*, kelp*, aloe vera* (BiAloe® concentrate), n-acetyl-l-cysteine, rutin, milk thistle extract, green tea extract, licorice root powder*, dandelion root powder*, rhodolia extract, inositol, biotin, stevia leaf extract, alpha lipoic acid, d-alpha tocopheryl succinate, niacinamide (Vit. B3), whole grape extract, high-gamma mixed tocopherols, phylloquinone (Vit. K1), immune assist mushroom extract, pantothenic acid, resveratrol, methylcobalamin (Vit. B12), pyridoxal-5’-phospate (Vit. B6), thiamin diphosphate (Vit. B1), riboflavin-5’-phosphate (Vit. B2), l-selenomethionone, cholecalciferol (Vit. D3), and calcium L-5-methyltetrahydrofolate.

*Organic ingredient  †VitaBerry Plus® is a registered trademark of VDF Futureceuticals, Inc.

rejuvenate berries & herbs nutrition facts table

RESOURCES:

Discover Rejuvenate! Berries & Herbs  (Product Page)

You may also like: Rejuvenate! PLUS (Product Page)

Did you know there are 3 different Rejuvenate! superfoods? Which one is best for you? See our Rejuvenate! superfood comparison page.

BLOG ARTICLES:

REJUVENATE! BERRIES & HERBS – SUPERFOOD FORMULA UPDATED

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What I’d Really Love to Tell You About the Methylation Cycle

Dr. Hank Liers, PhD geneticsI previously published “Homocysteine Genetics – Coenzyme B Vitamins” in which I considered in-depth how homocysteine (an intermediate chemical in the Methylation Cycle) is formed from methionine, how genetics affects the metabolic pathways, and how B vitamins are used in metabolic pathways. I also wrote “Folate Ingredients – Folinic Acid & 5-MTHF” which discussed how coenzyme folate vitamins are far superior to the synthetic folic acid form. In today’s article, I take a broader view of the topic that encompasses the Methylation Cycle, genetics, and B vitamins.

THE METHYLATION CYCLE

The Methylation Cycle is considered to be one of the most important metabolic pathways in the human body. Its most important function is to provide methyl groups via SAM (S-adenosyl methionine) to hundreds of different body substrates. Methylation is continually occurring in the body, transforming many millions of molecules throughout the body every second. Molecules receive methyl groups, then separate and recombine continuously, transforming and reforming constantly in the ongoing process of life!

As a reminder of the pathways involved in the Methylation Cycle, the following figure provides a flow chart showing the details.

 

Methylation Cycle

Figure 1. Metabolic Pathways in Methylation Cycle

A key purpose of this cycle is to provide methyl groups (CH3) needed by a broad range of of body functions (over 200 different functions). Examples include:

  1. Influences the genetic expression that parents give their children and helps guide the development of the embryo.
  2. Is needed by the nervous system to produce neurotransmitters and maintain the nerves.
  3. Mobilizes fats and cholesterol so they do not accumulate where they are harmful, such as the arteries and liver.
  4. Regulates hormones, including, estrogen, adrenaline, and melatonin.
  5. Detoxifies harmful chemicals and histamine a prime substance involved in inflammation.
  6. Helps repair damaged proteins in the cells so they can function properly.
  7. Protects the DNA in the genome (genetic code) to reduce the chances of mutation.
  8. Creates antioxidants used in the antioxidant defense system.

DESCRIPTION OF PATHWAYS WITHIN THE METHYLATION CYCLE

The overall flow of the Methylation Cycle begins with dietary methionine (an essential amino acid) which combines with ATP (adenosine triphosphate – body energy) to form SAM (S-adenosyl methionine) – the common cosubstrate involved in methyl group transfers, transsulfuration, and aminopropylation. When SAM transfers a methyl group to a body chemical the residue from this reaction leads to the production of homocysteine.

Homocysteine can be converted in the transsulfuration pathway that requires coenzyme vitamin B6 to produce cysteine, glutathione, taurine, and sulfates. These sulfur containing substances provide important antioxidant protection and detoxification functions in the body.

Homocysteine can be converted back to methionine through the betaine (trimethyl glycine) pathway which requires zinc and magnesium. This pathway also requires dietary betaine or choline which the body can convert into betaine.

Also, homocysteine can be converted back to methionine via the remethylation pathway which requires 5-MTHF, coenzyme vitamin B2 and methylcobalamin (B12).

GENETICS

It is important to understand that each of the pathways described above are able to be executed only in the presence of enzymes (shown in blue boxes in the diagram) created by specific genes in your genetic code. For example, Betaine-Homocysteine S-Methyltransferase (BHMT) is the enzyme required in the betaine pathway, Cystathione Beta Synthase (CBS) is the enzyme required in the transsulfuration pathway, and Methylenetetrahydrofolate Reductase (MTHFR) and Methionine Synthase (MS) are enzymes required in the remethylation pathway.

Assuming that you have perfect genetics (no mutations, SNPs, free radical damage, insertions/deletions, etc.), the proper functioning of these pathways are still subjected to the fact that the required vitamins and minerals (vitamin B6, vitamin B2, Folate, vitamin B12, zinc, magnesium, and betaine) need to be provided by your diet or from supplements for the body to function correctly.

In addition, exposure to high levels of toxins from your environment and high levels of stress require that the nutritional needs will be even higher for the pathways to work properly. For example, exposure to high levels of toxins requires that the transsulfuration pathway be more active possibly reducing the amount of available methionine to support necessary methyl transfer reactions.

For these reasons alone the consensus of knowledgeable practitioners is that you should be eating an organic whole foods diet, taking appropriate nutritional supplements, avoiding and eliminating toxins from food, water, and air (living in a clean environment), and avoiding an unduly stressful life. All of these actions fall into the category of Epigenetics which you generally have control over!! Doing these things alone could significantly balance the functioning of your Methylation Cycle and improve your health.

Unfortunately, few people have perfect genetics which often causes the various pathways in the Methylation Cycle to become imbalanced and unable to correct the dysregulation imposed upon the body. For example, the enzyme MTHFR can have heterozygous (single chromosome) genetic variations in up to 50% of certain populations and homozygous genetic variations (both chromosomes) in 10% or more of certain populations.

Some disorders that researchers have associated with MTHFR genetic variations include:

  • Alzheimer’s disease
  • Asthma
  • Atherosclerosis
  • Autism
  • Bipolar disorder
  • Bladder issues
  • Blood clots
  • Breast problems
  • Chemical sensitivity
  • Chronic fatigue syndrome
  • Down syndrome
  • Epilepsy
  • Fibromyalgia
  • Gastric problems
  • Glaucoma
  • Heart murmurs
  • High blood pressure
  • Irritable bowel syndrome
  • Leukemia
  • Male infertility
  • Methotrexate toxicity
  • Migraines with aura
  • Multiple sclerosis
  • Myocardial infarction
  • Nitrous oxide toxicity
  • Parkinson’s disease
  • Pulmonary embolisms
  • Schizophrenia
  • Stroke
  • Thyroid issues
  • Unexplained neurologic disease
  • Vascular dementia

This extensive list is highly significant and tells us that it is very important to have genetic testing done for the genes/enzymes in the Methylation Cycle pathway. I prefer the BodySync genetic test which evaluates the key Methylation Cycle genes plus many other important genes in a single test.

B VITAMINS AND MINERALS

We are strong believers that everyone should start their nutritional program by eating a balanced, organic, whole foods diet. We have been doing this ourselves for the past 30 years. Unfortunately, only a small percentage of people follow this advice and in most cases this leads to poor nutritional status that does not adequately support the body’s needs. This is especially true with respect to obtaining the nutrients needed to support the Methylation Cycle.

Nine of our family members and associates have taken the BodySync genetic test which evaluates the condition of 45 different enzymes including CBS, MTHFR (2 variations), MTR (related to B12 and 5-MTHF as they relate to methionine synthase – MS), and MTRR (related to maintaining B12 levels needed by the MTR enzyme). In every case the results showed at least 2 and up to 4 enzymes had genetic variations. These results indicate that the nutritional requirements for folate as 5-MTHF, vitamin B12 as methylcobalamin, vitamin B6, vitamin B2, magnesium and zinc will likely be significantly greater than normal.

Given the above information, it seems essential for good health to take nutritional supplements that provide the important nutrients. Below I will discuss various formulas that I have developed and refined over many years that are useful especially for the Methylation Cycle.

Please note that Health Products Distributors, Inc. (HPDI) is the preferred supplier of nutritional supplements by the BodySync genetic testing company.

MULTIVITAMINS

When looking at the total needs the body has for nutrients that the body does not produce, including fat soluble vitamins (A, D (some), E, K1 and K2), vitamin C, B vitamins (B1, B2, B3, B5, B6, folate, B12, biotin, choline, and inositol), minerals (Ca, Mg, Zn, Se, Cu, Mn, Cr, Mo, K, boron, and vanadium), and betaine it only seems wise to include as a top priority a Multivitamin that includes all of these in what I term therapeutic amounts (carefully selected after evaluating thousands of research studies carried out over many years.)

In this context, it is important to recognize that every enzymatic reaction in the body requires mineral cofactors in order to carry out its function. A good multivitamin provides many of these required minerals.

Additionally, the multivitamin should contain ingredient forms that research has confirmed to be the most absorbable and usable by the body. These include coenzyme B vitamins, Krebs cycle (citrate, alpha-ketoglutarate, succinate, fumarate, & malate) minerals, and amino acid chelates.

In the context of supporting the Methylation Cycle we are looking for specific forms and amounts of B vitamins that can adequately provide the body’s needs. The means that there should be coenzyme folate as 5-MTHF of at least 400 mcg, coenzyme vitamin B-12 as methylcobalamin of at least 200 mcg, Vitamin B6 (including significant amounts of pyridoxal 5′ phosphate) of at least 40 mg, and Vitamin B2 (including significant amounts of riboflavin 5′ phosphate) of at least 25 mg. In addition, magnesium (100 mg) and zinc (at least 20 mg) should be provided.

Please note that the body’s requirements for magnesium is generally accepted by nutritional experts to be higher than 400 mg daily (and as high as 1,000 mg daily). For this reason we generally recommend that a person take supplemental magnesium (such as HPDI’s MYO-MAG) at levels over 400 mg daily.

The two multivitamin formulas Health Products Distributors provides for adults that meet these requirements (and more) are the Hank & Brian’s Mighty Multi-Vite and Multi Two (in both capsule and tablet forms). Click on the bottles below for technical details.

Hank & Brian's Mighty Multi-Vite multivitamin methylation cycle

Multi Two Caps or Tablets methylation cycle

B COMPLEX

In situations where significant genetic variations are present it may be wise to add a B COMPLEX supplement to the MULTIVITAMIN to provide even larger amounts of the needed B vitamins. HPDI provides a B-Complex-50 product that includes significant amounts of coenzyme forms and contains 50 mg of Vitamin B1, 50 mg of Vitamin B2, 100 mg of Vitamin B3, 50 mg of Vitamin B6, 500 mcg of coenzyme folate (both folinic acid and 5-MTHF), 100 mcg of B12 (both methylcobalamin and hydroxocobalmin), 50 mg of Vitamin B5 (pantothenic acid), 500 mg of Biotin, 50 mg of choline, and 50 mg of inositol. Click on the bottle below for technical details.

B-Complex-50 full spectrum B vitamins with coenzyme forms methylation cycle

FOLATE AS 5-MTHF

In situations where an inadequate diet is present and genetic testing indicates an MTHFR variation (especially a homozygous variation) Health Products Distributors provides a 5-MTHF folate supplement that easily absorbs into the body and can be directly used in combination with Vitamin B12 to convert homocysteine to methionine. Click on the bottle below for technical details.

5-MTHF 1 mg in veggie cap methylation cycle

5-MTHF 1 mg in veggie cap

B-12 as METHYLCOBALAMIN

It is often the case for older patients and vegetarians that Vitamin B12 is deficient. In these cases it is wise to supplement with a significant amount of methylcobalamin to ensure that the Methylation Cycle has sufficient to effectively convert homocysteine into methionine. Health Products Distributors Vitamin B12 contains 5 mg of methylcobalamin in sublingual lozenge form that supports excellent absorption even if swallowed and absorbed by diffusion. Click on the bottle below for technical details.

Vitamin B-12 5 mg methylcobalamin sublingual lozenge methylation cycle

Vitamin B-12 – 5 mg Methylcobalamin sublingual lozenge.

MINERALS

Magnesium and zinc are two important minerals used in the betaine pathway of the Methylation Cycle in which homocysteine is converted back to methionine.

In the body magnesium is involved in more than 400 essential metabolic reactions and is required by the adenosine triphosphate (ATP)-synthesizing protein in mitochondria. ATP, the molecule that provides energy for almost all metabolic processes, exists primarily as a complex with magnesium (MgATP). Therefore, it also is involved in converting methionine to SAM.

Over 300 different enzymes depend on zinc for their ability to catalyze vital chemical reactions. Zinc-dependent enzymes can be found in all known classes of enzymes.

Health Products Distributors provides 100 mg magnesium/vcap in its MYO-MAG supplement which is especially important in increasing ATP in the Krebs Cycle. This product also contains vitamin B1, vitamin B2, and vitamin B6 with substantial amounts of coenzyme forms and manganese. Click on the bottle below for technical details.

MYO-MAG with 100 mg magnesium per serving key B vitamins methylation cycle

MYO-MAG with 100 mg magnesium per serving and key B vitamins.

Health Products Distributors provides 25 mg zinc/serving in its Double Zinc Plus supplement. This formula provides zinc in the picolinate and citrate forms as well as 3 mg of P5P (coenzyme B6). Click on the bottle below for technical details.

Double Zinc Plus supplement with P5P and 25 mg zinc methylation cycle

Double Zinc Plus supplement with P5P and 25 mg zinc

SUMMARY

The Methylation Cycle is recognized as one of the most important metabolic pathways in the human body. When not properly supported by key B vitamins and minerals, the Methylation Cycle can become severely imbalanced which can lead to a very wide range of poor health conditions. Furthermore, genetic variations in the genes that produce important enzymes allowing the Methylation Cycle to function correctly lead to even further imbalances and greater possibility for conditions of poor health.

In this article, I have provided insight into how the Methylation Cycle works and how it can be significantly supported by lifestyle changes regarding diet and environment (Epigenetics) and by specific B vitamins and mineral supplements that I have developed over many years. In addition, we have shown that knowledge gained from genetic testing can further provide a critical understanding of your specific needs so that your health can be optimized.

RELATED HPDI BLOG ARTICLES

Homocysteine Genetics – Coenzyme B Vitamins

 

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HOW TO MAKE KETO COFFEE USING pH ADJUST

Fred Liers PhD keto coffee pH Adjust alkalinizeWe can all stand to be more alkaline. The majority of people are acidic due to diet and lifestyle. One of the best formulas for creating alkalinity is pH Adjust. pH Adjust is a good-tasting, fluffy white powder that dissolves easily in water, juice, and yes, coffee.

Shortly after launching pH Adjust as a new product, we began receiving reports from customers that they used pH Adjust in their coffee.

Why put pH Adjust into coffee? Well, first it is a pleasant and convenient carrier for pH Adjust. Second, and most importantly, coffee is acid-forming in the body. By putting pH Adjust directly into coffee, you both can counteract acidity and simultaneously alkalinize the body.

My questions: Was coffee creating acid condition in my body? And would putting pH Adjust in my coffee make a a difference? Short answer: Yes.

I enjoy coffee. I don’t drink it all the time. But after hearing customer comments, I decided to try pH Adjust in my coffee. Within a day or two, I noticed my teeth were stronger! This was welcome news.

In fact, I had been dealing with a few “minor” dental issues, including teeth chipping, enamel wear, and occasional tooth pain. My diet is good and I eat plenty of vegetables and fruits. So how could my teeth be compromised?

I measured my pH using Hydrion pH paper. It was lower than I thought it would be. Simply put: I was more acidic, more of the time, than I knew. Does acidity weaken teeth? Yes, it does.

ph Adjust keto coffee

pH Adjust alkalinizes the body rapidly. It dissolves easily in water, coffee & most drinks.

“Bicarbonate reserves” decline as we age. This makes us more acidic because we don’t buffer acidity as easily as we did when younger. The body must then draw upon minerals in bones and teeth. Yet, even young people are overly acidic in modern society. Everyone who is acidic stands to benefit from increased pH levels. That means most of us.

The proof that acidity causes weaker teeth is the fact that pH Adjust immediately stopped my tooth chipping, enamel wear, and pain. Good thing I put pH Adjust into coffee shortly after HPDI introduced it. And thanks to the customers, employees, and friends of HPDI who told me about it.

ALKALINIZING COFFEE IS HEALTHIER

Coffee with pH Adjust is healthier than plain coffee because it helps alkalinize the body. Taking pH Adjust (without coffee) accomplishes the same thing. But for those who enjoy coffee, adding pH Adjust is an easy way to alkalinize what can otherwise be an acidifying drink. Who wants acidity? Not me.

I now use pH Adjust in coffee by directly adding a 1/2 to 1 teaspoon directly into coffee and stirring. I adjust the dose according to how much coffee I drink.

I also take pH Adjust separately from coffee—usually once or twice daily—about one teaspoon per dose. Taking 1–2 teaspoons total of pH Adjust daily seems to be the right amount. I no longer have issues with my teeth. My bones feel stronger, too.

If you drink coffee, then adding pH Adjust to make it “pH Adjust coffee” may be helpful to you. It reduces acidity and supports mineral balance. It especially provides good levels of potassium and magnesium, minerals that are required for good health—and that are deficient in most people.

If coffee is driving acidity in your body, then pH Adjust may be just the thing for you. Putting pH Adjust in your coffee directly means stopping acidity at the source. pH Adjust dissolves easily in coffee (and most other drinks) and does not add a bad taste. In fact, many people, including me, enjoy the gently sweet flavor it imparts.

pH test paper litmus keto coffee

Test pH using Hydrion litmus paper.

KETOGENIC COFFEE WITH pH ADJUST

More recently, I discovered the benefits of using organic coconut or MCT oil in coffee with organic pasture butter or ghee. This is based on the concept of Bulletproof coffee popularized by Dave Asprey in his Bulletproof Diet, and it fits well into ketogenic diets. Ketogenic diets are low in carbohydrates, high in fats, and include plenty of high-quality protein.

I do not follow a ketogenic diet per se. Yet, I consume relatively high amounts of “good” fats (like coconut, olive, and avocado oils) and few simple carbohydrates. I had even added coconut oil, butter, and ghee into my coffee years ago. But I never blended it into an emulsified concoction, nor was pH Adjust available. So this is truly different!

MAKE KETO COFFEE

I make ketogenic or “keto” coffee using freshly ground organic coffee, organic coconut oil and/or organic MCT oil, and organic unsalted ghee (or pasture butter). It is important the ingredients be organic and pasture fed when possible.

I first brew the coffee, then add coconut oil or MCT oil, and butter or ghee. Then I use a hand blender (or regular blender) to mix completely.

INGREDIENTS

• 8–16 ounces freshly brewed coffee

• 1–2 tablespoons of Coconut oil or MCT oil

• 1 teaspoon–2 tablespoons of unsalted ghee (or unsalted pasture butter)

• 1/2 tsp–2 teaspoons pH Adjust (to taste, depending on quantity desired)

Put freshly brewed coffee in a blender or large container (like a mason jar). Add coconut oil/MCT oil, ghee, and pH Adjust. Blend or use hand blender to mix well. It is important the coffee be hot (or at least warm) in order for the coconut/MCT oil and ghee to mix into it.

You can add the pH Adjust either before or after you mix or blend the coffee. I personally stir in the pH Adjust manually using a long spoon after I’ve already mixed the other ingredients. If you add the pH Adjust after mixing the other ingredients, then be sure to stir well.

Note on amounts: the amounts I list above are suggestions. I often use less coconut or MCT oil, or ghee. That is, some days I use just two teaspoons of coconut/MCT oil, or one rounded teaspoon of ghee. Try using different amounts of ingredients to see what works for you.

Keto Coffee Ghee Butter

Grass-fed ghee is a key ingredient in keto coffee.

One reason for using less coconut/MCT oil or ghee is because this coffee can be “filling.” I am not hungry after I drink it. This is one benefit according to keto coffee experts. In fact, it is recommended that users drink it in the morning before eating. This gives the option of putting off breakfast.

If I have planned to eat breakfast, then I will often use less coconut or MCT oil. The lower level of satiety from the coffee means I eat breakfast without having already been filled by the keto coffee.

Make keto coffee any time of day. It is probably best on an empty stomach and definitely not too late into the afternoon—unless you want to be up late (if coffee affects you that way). You can make it early in the day, and then consume it over the course of the morning and afternoon.

Benefits of Coffee or Keto Coffee with pH Adjust

• Alkalinizes body — an alkaline state is good for overall health

• Provides minerals, especially potassium and magnesium

• May help strengthen teeth and bones

• Some users report improved digestion

• Some users report reduced GERD

• Some users report less Restless Leg Syndrome (RLS)

• Potassium helps balance out sodium — and is required for cellular health

• Magnesium is essential for 400 enzyme systems, production of ATP, cardiovascular health, and muscle relaxation

• Many other benefits!

There are many other benefits associated with an alkaline state, which is ideally a pH of 7.35–7.45. You can learn more about the benefits of alkalinization from earlier HPDI blog articles (see resources section below), doing web searches, or talking to your health professional.

If these benefits are not sufficient reason to try using pH Adjust in your coffee to make “pH Adjust alkalinizing coffee” then consider doing it for the taste!

Tip: To make this coffee more hydrating, try adding 8-16 drops of Patrick Flanagan’s Crystal Energy, which makes the water in this drink more bioavailable.

keto coffee ingredients MCT oil ghee

KETO COFFEE TASTES GOOD

Keto coffee tastes good. The oils and fats provide a rich, hearty taste. It is creamy, warm, and delicious. And as I mentioned, it is filling, so it satisfies hunger.

Adding pH Adjust to keto coffee won’t change the taste much. In fact, many people say adding pH Adjust makes it taste better. I agree. This may be due to the fact that the formula contains glycine in the form of potassium glycinate. Glycine tastes good and is naturally “sweet” without the harmful effects of sugar. In fact, to me pH Adjust imparts a slightly sweet flavor that is reminiscent of “caramel.”

pH Adjust may slightly change the texture of your coffee. It may make regular, non-keto coffee appear and taste “creamier.” Most people won’t mind that. As for keto coffee, it is already “creamy” due to the coconut/MCT oil and ghee. pH Adjust might just add a bit more texture to it.

Also, there may be a slight chalky, white residue at the bottom of your cup. This does not happen if you mix in the pH Adjust formula well, or if you re-stir (or swirl) the coffee cup or glass when it’s half full. Remember: if you see this residue, it is pH Adjust. As such, you may wish to drink it as is, or add little more liquid (coffee, water, etc.) and quaff it down.

keto coffee blender drink

Mix the MCT or coconut oil and ghee (or butter) using a blender or stick blender.

DRINK pH ADJUST FOR ALKALINITY

To me, the most important thing about coffee or keto coffee with pH Adjust is not how it tastes or how it reduces hunger, etc. It is how is increases pH levels. Alkalinity is important for health. No matter how you choose to take or drink it, pH Adjust will alkalinize. In spades.

Besides coffee, you can add pH Adjust to juices, teas, smoothies, shakes, water, and even lemonade. The fact is, taking pH Adjust is more important than the drink you choose to take it with. You decide the drink.

That being said, I really like keto coffee with pH Adjust. I add ice for a delightful, cooling concoction in summer. In winter, I drink it hot.

I think you will enjoy keto coffee with pH Adjust, too. And, if you already brew and drink your own version of keto coffee, then increased alkalinity—and better health—is as simple as adding a spoonful of pH Adjust. ~

RESOURCES

HPDI BLOG ARTICLES

Alkalizine with Lemonade Diet and pH Adjust

Got Potassium?

Racing and Recovery with pH Adjust Alkalinizing Formula

Alkalinize Rapidly Using pH Adjust

pH Adjust Alkalinizing Formula – New Product!

BOOKS & ARTICLES

Acid-alkaline balance: role in chronic disease and detoxification
(Altern Ther Health Med, 13(4):62-5)

Acid & Alkaline by Herman Aihara

Bicarb Magical Mineral Supplement by Dr. Mark Sircus, Ac, OMD

The Bulletproof Diet by Dave Asprey

Head Strong by Dave Asprey

The High Blood Pressure Solution by Richard D. Moore, MD, PhD

The K Factor: Reversing and Preventing High Blood Pressure without Drugs by Richard D. Moore, MD, PhD

Keto: The Complete Guide to Success on The Ketogenic Diet by Maria Emmerich

Simply Keto: A Practical Approach to Health & Weight Loss by Suzanne Ryan

The XXL Syndrome by Max Rombi, MD

LISTS & REFERENCE

The Acid Alkaline Food Guide
by Dr. Susan Brown and Larry Trieviei, Jr.

Potassium Intake of the US Population (PDF)
(NHANES Food Surveys Research Group, USDA)

Potassium: Health Benefits, Recommended Intake

List of acid-forming and alkaline forming foods

PRODUCTS

pH Adjust
(Dr. Hank Liers’ original formula)

pH paper (roll)
(Hydrion litmus paper)