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BONE FRACTURES SUPPORT

Dr. Hank Liers, PhD bone fracturesSeveral years ago a customer asked me for a program that could be helpful to those suffering with bone fractures. A relative had been diagnosed with multiple bone fractures in his ankle.

Since I have been counseling individuals regarding natural treatments for supporting those with bone fractures and injury for many years, I was able to provide a comprehensive program that could be helpful in recovery. More recently, we have introduced products and tools that can be even more supportive. Therefore, in this article we are providing an update to the bone fractures program.

Clearly, the need for such a program is great. According to the American Academy of Orthopaedic Surgeons (AAOS), about six million individuals suffer fractures each year in North America. In about 5–10 percent of cases, patients suffer either delayed healing or fractures that do not heal.

The problem of bone fractures is especially troubling for the elderly, many of whom suffer from osteoporosis, a condition in which bones become weak and break more easily. For an older person, a fracture affects quality of life because it significantly reduces function and mobility, and requires an extended period of recuperation.

The bone fracture program set forth below also works well to support the healing of other types of bone problems, including broken bones, bone surgery, osteoporosis, and wisdom tooth removal.

THE BONE FRACTURE PROGRAM

IMPORTANCE OF FOUNDATIONAL SUPPLEMENTS

The first element of the program consists of Foundational Supplements. This group of supplements ensures the body is being supplied with all of the basic elements needed for optimal function. The primary foundational supplements consists of 1) a therapeutic multivitamin and mineral formula, 2) a complete buffered Vitamin C with antioxidants formula, 3) an essential fatty acids supplement, and 4) a high-RNA superfoods formula.

Our Foundational Supplements are described in great detail on the HPDI website where we provide a free downloadable e-book “The Need for Foundational Supplements” (.pdf). Suffice it to say that the foundational supplements are a essential part of the program that ensure healing will take place quickly and effectively. I encourage everyone to become familiar with this information as foundational supplements are basic to any wellness or healing program.

bone fractures

ENHANCEMENT FORMULAS ARE CRITICAL FOR HEALING BONE FRACTURES

The second element of the program for healing bone fractures consists of Enhancement Formulas that strengthen the body as it relates to dealing with the damaging effects of bone fractures. These include a Vitamin D3 formula with the synergistic nutrients of Vitamin A and Vitamin K2 that are required for the rebuilding of bone as well as strengthening the body in many other ways. The HPDI Vitamin D3 Plus formula to designed to specifically address this need.

A second Enhancement Formula in this program is our comprehensive Bone Guardian formula that is based upon micronized veal bone that provides hydroxyapatite (Ca10(PO4)6(OH)2). Hydroxyapatite is the basic component of human bone that is 50% by volume and 70% by weight. Whereas the Vitamin D3 Plus formula builds the bone matrix, the Bone Guardian fills in the matrix with materials such as calcium, phosphorus, magnesium, boron, zinc, manganese, copper, silica, and strontium. HPDI sells Bone Guardian in both the tablet and capsule forms. The capsule form may be better for older people who are able to absorb capsules better than tablets.

A third Enhancement Formula to the program is additional amounts of Vitamin C. Vitamin C is known to participate in every step of the process of building collagen, which is a key component of bone. Vitamin C has been shown to increase bone mass density. We recommend slowly increasing your intake of buffered Vitamin C until you reach your bowel tolerance. This can be accomplished by increasing your intake of HPDI’s foundational supplement PRO-C™ formula. The PRO-C has the added value of containing oligomeric proanthocyanidins (OPCs) from grape seed, skin, & pulp. OPCs in the body are able to strongly crosslink and strengthen new and damaged collagen fibers needed needed to repair bones, ligaments, tendons, and cartilage.

SPECIFIC CONDITION FORMULAS TARGET BONE FRACTURES

The third element in the program are Specific Condition Formulas that directly address issues related to bone fractures. The first of these is the addition of a joint formula that allows the body to build and repair connective tissue and to significantly reduce inflammation in the area of bone fractures. In most cases of fractures there will be damaged ligaments and tendons as well as inflammation in the area.

HPDI’s Joint Health Formula includes the ingredients glucosamine hydrochloride, MSM, and sea cucumber (a significant source of chondroiten sulfate) in addition to anti-inflammatory substances such as turmeric extract, rutin, and grape extract (seed, pulp, and skin) that have been extremely helpful in both repairing connective tissue and reducing pain and inflammation.

A second strongly recommended condition-specific formula is proteolytic enzymes. Because it is highly likely in the case of bone fractures and injury that there is significant tissue damage, a formula with pancreatic and plant enzymes as well as anti-inflammatories can be extremely helpful is clearing out the damaged tissue. This gives the body the opportunity to begin the rebuilding process much sooner.

Our recommended PROLYT formula contains the proteolytic enzymes bromelain, trypsin (pancreatic enzyme), and chymotrypsin (pancreatic enzyme), and the polyphenols/bioflavonoids turmeric extract (95% curcuminoids), quercetin and oligomeric proanthocyanidins (OPCs) from grape extract. This formula when taken on an empty stomach between meals is quickly absorbed into the bloodstream and goes to work cleaning up any damaged tissues in the area surrounding a fracture and assists in reducing pain and inflammation.

TOPICAL MAGNESIUM CHLORIDE FOR PAIN AND RAPID HEALING

A final Specific Condition Formula that I highly recommend for healing bone fractures is to rub Ancient Minerals Magnesium Oil on and surrounding the fracture area. Bones cannot heal without having adequate amounts of magnesium available. Unfortunately, many people are deficient in magnesium and even taking oral magnesium cannot easily provide sufficient amounts to an area with a bone fracture. Magnesium oil (mostly magnesium chloride) is quickly absorbed transdermally (via skin) and often can provide rapid healing and pain relief!

BODY pH COULD BE A FACTOR IN HEALING BONE FRACTURES

The processed food diets with a high protein and low vegetable content consumed by many people in the U.S. and elsewhere often produce conditions in the body of acidity. This in turn leads to decreased oxygenation of cells and encourages a greater amount of anaerobic processes in metabolism. In addition, when the body is acidic calcium can be taken from bones in order to balance the acidity. This can lead to poor healing of bone fractures.

In order to counter acidic conditions in the body we recommend the use of HPDI’s pH ADJUST formula. As a dietary supplement, take 1 gm (about a rounded ¼ tsp) in 4-8 ounces of purified water preferably away from food, or as directed by a health care professional.  For extremely acidic conditions, try 4–10 doses per day, depending on acidity level. Use pH paper to ensure pH levels remain balanced, and do not become too alkaline (alkalosis may occur above pH 8.2).

TESTING pH LEVELS: The best way to test pH levels is to use litmus paper, which HPDI offers in rolls (Hydrion brand) for this purpose. You can test salivary or urinary pH. In order to test salivary pH, simply use a small strip of pH paper to dip into a small amount of saliva. Advantages of pH paper include rapid results, ease of use, and cost effectiveness.

pH Paper bone fractures protocol

The color of the litmus paper indicates the pH level of the body fluid tested. Most litmus paper comes with an indicator chart showing colors corresponding to various pH levels. Alkaline states will generally produce a dark green, blue or purple color (most basic). Acidic states will range from yellow (most acidic) to light green.

Salivary pH and urinary pH are significantly affected by recent food consumption and other factors, so it it best to test pH hours after meals or in the morning when you awake. We prefer to measure urinary pH since results are more consistent. Measuring urinary pH is a simple as placing a few drops of urine on the paper or dipping the paper into a sample cup of fresh urine.

A consistent pH measurement of less than 7.0 indicates that you are too acidic (values less than 6.2 show extreme acidity). This indicates that you should consume more alkaline forming foods (usually vegetables) and/or take pH ADJUST. A single dose of pH ADJUST can change conditions in the body from acidic to alkaline within a few hours.

GENETIC VARIATIONS IN YOUR VITAMIN D RECEPTOR GENE (VDR) MAY BE AN IMPORTANT FACTOR

The VDR gene (contained in every cell of the body) provides instructions for making a protein called vitamin D receptor (VDR), which allows the body to respond appropriately to vitamin D. This vitamin can be acquired from foods in the diet or made in the body by exposure to from sunlight. Vitamin D is involved in maintaining the proper balance of several minerals in the body, including calcium and phosphate, which are essential for the normal formation of bones and teeth. One of vitamin D’s major roles is to control the absorption of calcium and phosphate from the intestines into the bloodstream. Vitamin D is also involved in several process unrelated to bone formation.

VDR attaches (binds) to the active form of vitamin D, known as calcitriol. Calcitrol is produced in the body from Vitamin D3 (cholecalciferol) in the liver and kidneys. The interaction with calcitriol allows VDR to partner with another protein called retinoid X receptor (RXR). The resulting complex of proteins then binds to particular regions of DNA, known as vitamin D response elements, and regulates the activity of vitamin D-responsive genes. By turning these genes on or off, VDR helps control calcium and phosphate absorption and other processes.

In recent years, genetic tests have become available that show VDR variations can cause serious conditions related to low bone density and other important body functions such a higher blood glucose levels or lower immune system function. If a person is having little success in healing bone fractures, it is possible that VDR variations are a key factor of causation.

In such cases, we recommend having genetic testing done to determine if VDR variations are present. Recently, HPDI has teamed with a genetic testing company (BodySync, Inc.) and sells the BodySync test kits on our Reseller site. Please click here to see our blog article regarding the BodySync genetic test. Among the genes tested for in the test are three variations of the VDR gene. Resellers can purchase the test kits directly from HPDI and retail customers can call us  (800-228-4265) to find out how we can help them get a test kit and support them with any associated counseling regarding the results.

SUGGESTED SUPPLEMENT SCHEDULE – BONE FRACTURES

I have included all of the above supplements including recommended dosages plus more related to having an excellent diet in the table provided below.

Description AM Noon PM Night Comments
PRO-C 2 caps 2 caps 2 caps Take with meals or with snack.
Bone Guardian 

Bone Guardian Caps (easier to absorb)

3 tabs

3 caps

 

3 caps

3 tabs

3 caps

Take with meals.

Take with meals.

Mighty Multi-Vite! or
Multi Two — Multivitamins
2 caps or
1 tab
2 caps or
1 tab
Take with meals.
Essential Fats plus E 2 softgel 2 softgel 2 softgel Take with meals.
PROLYT – Proteolytic Enzyme Formula 2 caps 2 caps 2 caps 2 caps Take between meals.
Buffered Vitamin C, Tablets — 1,000 mg (1 gm) or Powder (1/4 tsp = 1 gm) 2 tabs or
1/2 tsp
2 tabs or
1/2 tsp
2 tabs or 1/2 tsp 2 tabs or 1/2 tsp Best with meals, but other times are okay. Start with 2 tabs or 1/2 tsp twice per day and add another 2 tabs or 1/2 tsp every few days until you are taking 8 tabs or 2 tsp per day.
Vitamin D3 Plus 5,000 IU 1 softgel 1 softgel Take with meals. Reduce to 1 softgel after 2 months.
Joint Health Formula 2 caps 2 caps 2 caps Take between meals and away from Bone Guardian.
Magnesium Oil 10 pumps 10 pumps 10 pumps 10 pumps Spray on affected area – or nearby area.
Rejuvenate! Plus or
Rejuvenate! (original)
1 scoop 1 scoop Take as a meal by itself or with fruit/berries.

ADDITIONAL NUTRIENTS FOR BONE FRACTURES

Additional nutrients that may be helpful include pH ADJUST (to balance excess acidity in the body),  Warrior Mist™ for pain relief (rub on adjacent area several times daily), Echinacea (as drops or capsules), N-Acetyl-L-Cysteine – NAC (2 gms per day), Progesterone Cream – for women (1/4–1/2 tsp twice daily), and Prescript-Assist™ probiotics (2 capsules daily) if on antibiotics.

PROPER DIET IS ESSENTIAL

Consume a diet that provides good amounts of protein which is needed by the body to support the healing of bone fractures. Eat meats, poultry and fish (e.g., sardines, salmon, mackerel) in the amount of a 5–10 ounces per day. Ensure a good intake of organic vegetables, including high levels of dietary fiber. Drink 16 oz per day of fresh vegetable juices from carrot, celery, beets, cabbage, etc.

Other healthy foods (preferably organic) include fruits, whole grains (e.g., brown rice, millet, and quinoa), beans, nuts and seeds (sunflower, chia, flax, pumpkin, almond, walnut and sesame in small amounts — 2 or 4 ounces — are good). Try eating Hank’s Vegetable Soup several times a week. Avoid all sweets (sugar), processed/refined foods (white bread and pasta), preservatives, and artificial flavors and colors. Vary your diet.

HYDROTHERAPY (WATER THERAPY) FOR BONE FRACTURES

An additional treatment that can be useful is hydrotherapy. In particular, hot and cold showers are a very effective way to move the blood and create circulation. This can speed up both detoxification and delivery of healing nutrients to the area of a bone fracture. Here’s how to do this. Once daily, take a complete hot and cold shower. You will start with hot water for one minute, then cold for one minute. Repeat this seven (7) times so the shower should last about 15 minutes.

Another time, daily, you can perform a complete hot and cold shower routine again or a partial one just applying the water directly to or near the area where there is a bone fracture. While you are doing both hot and cold showers, pay special attention to any affected area and massage it as vigorously as is safe and comfortable. If a shower is impossible, then alternate hot packs and ice packs on the area of the bone fracture.

BONE FRACTURES – CONCLUSION

By following the recommendations and suggested supplement schedule, healing time for bone fractures can be significantly reduced and fractures may heal more completely with fewer complications. By ensuring your body receives the proper nutrients it needs to heal itself, and by engaging in other relevant practices (e.g., hydrotherapy), you and/or your loved ones may be able to deal with bone fractures successfully, and continue a healthy, vibrant lifestyle.

ADDITIONAL RESOURCES

HPDI REJUVENATION PROGRAM

REJUVENATION PROGRAM PART 6 (INCLUDES HYDROTHERAPY)

REJUVENATE!™ SUPERFOODS

ULTIMATE PROTECTOR™

“FRED’S FAVORITE VEGETABLE JUICE RECIPE: ‘THE DOCTOR'”

1

Natural Treatment Plan for Healing Bone Fractures

Dr. Hank Liers, PhD healing bone fracture treatment plan natural healingSeveral weeks ago a man called asking me for a program to heal bone fractures. His son recently was diagnosed with multiple bone fractures in his ankle. I have been counseling individuals regarding natural treatments for healing bone fractures and injury for the past 20 years, and quickly provided a comprehensive program for his son.

I share the program details (below) so that all readers (including you) can benefit from it as needed. Clearly, the need for such a program is great. According to the American Academy of Orthopaedic Surgeons (AAOS), about six million individuals suffer fractures each year in North America. In about 5–10 percent of cases, patients suffer either delayed healing or fractures that do not heal.

The problem of bone fractures is especially troubling for the elderly, many of whom suffer from osteoporosis, a condition in which bones become weak and break more easily. For an older person, a fracture affects quality of life because it significantly reduces function and mobility, and requires an extended period of recuperation.

The bone fracture program I set forth below also works well with other types of bone problems, including broken bones, bone surgery, osteoporosis, and wisdom tooth removal.

THE BONE FRACTURE PROGRAM

 

IMPORTANCE OF FOUNDATIONAL SUPPLEMENTS

The first element of the program consists of Foundational Supplements. This group of supplements ensures the body is being supplied with all of the basic elements needed for optimal function. The foundational supplements consists of 1) a therapeutic multivitamin and mineral formula, 2) a complete buffered Vitamin C with antioxidants formula, 3) an essential fatty acids supplement, and 4) a high-RNA superfoods formula.

Our Foundational Supplements are described in great detail on the HPDI website where we provide a free downloadable e-book “The Need for Foundational Supplements” (.pdf). Suffice it to say that the foundational supplements are a essential part of the program that ensure healing will take place quickly and effectively. I encourage everyone to become familiar with these materials as they are basic to any healing program.

Healing from broken bones

ENHANCEMENT FORMULAS ARE CRITICAL FOR HEALING BONE FRACTURES

The second element of the program for healing bone fractures consists of Enhancement Formulas that strengthen the body as it relates to dealing with the damaging effects of bone fractures. These include a Vitamin D3 formula with the synergistic nutrients of Vitamin A and Vitamin K2 that are required for the rebuilding of bone as well as strengthening the body in many other ways. I formulated the HPDI Vitamin D3 Plus formula to specifically address this need.

A second Enhancement Formula in this program is our comprehensive Bone Guardian formula that is based upon micronized veal bone that provides hydroxyapatite – the basic component of bone structures. Whereas the Vitamin D3 Plus formula builds the bone matrix, the Bone Guardian fills in the matrix with materials such as calcium, phosphorus, magnesium, boron, zinc, manganese, copper, silica, and strontium.

A third Enhancement Formula to the program is additional amounts of Vitamin C. Vitamin C is known to participate in every step of the process of building collagen – a key component of bone. Vitamin C has been shown to increase bone mass density. We recommend slowly increasing your intake of buffered Vitamin C until you reach your bowel tolerance. This can be accomplished by increasing your intake of foundational supplements, including HPDI’s PRO-C™ or Ultimate Protector™ formulas, or at a somewhat lower cost by using Buffered C tablets or powder.

SPECIFIC CONDITION FORMULAS TARGET BONE FRACTURES

The third element in the program are Specific Condition Formulas that directly address issues related to bone fractures. The first of these is the addition of a joint formula that allows the body to build and repair connective tissue and to significantly reduce inflammation in the area of bone fractures. In most cases of fractures there will be damaged ligaments and tendons as well as inflammation in the area.

HPDI’s Joint Health Formula includes the ingredients glucosamine hydrochloride, MSM, and sea cucumber (a significant source of chondroiten sulfate) in addition to anti-inflammatory substances such as turmeric, rutin, and grape seed extract that have been extremely helpful in both repairing connective tissue and reducing pain and inflammation.

A second strongly recommended condition-specific formula is proteolytic enzymes. Because it is highly likely in the case of bone fractures and injury that there is significant tissue damage, a formula with pancreatic and plant enzymes as well as anti-inflammatories is extremely helpful is clearing out the damaged tissue. This gives the body the opportunity to begin the rebuilding process much sooner.

Our recommended PROLYT formula contains the proteolytic enzymes bromelain, trypsin (pancreatic enzyme), and chymotrypsin (pancreatic enzyme), and the polyphenols/bioflavonoids turmeric extract (95% curcuminoids), quercetin and oligomeric proanthocyanidins from grape seed extract. This formula when taken on an empty stomach between meals is quickly absorbed into the bloodstream and goes to work cleaning up any damaged tissues in the area surrounding a fracture and assists in reducing pain and inflammation.

TOPICAL MAGNESIUM CHLORIDE FOR PAIN AND RAPID HEALING

A final Specific Condition Formula that I highly recommend for healing bone fractures is to rub Ancient Minerals Magnesium Oil on and surrounding the fracture area. Bones cannot heal without having adequate amounts of magnesium available. Unfortunately, many people are deficient in magnesium and even taking oral magnesium cannot easily provide sufficient amounts to an area with a bone fracture. Magnesium oil (mostly magnesium chloride) is quickly absorbed transdermally (via skin) and often can provide rapid healing and pain relief!

I have included all of the above supplements including recommended dosages plus more related to having an excellent diet in the table provided below.

SUGGESTED SUPPLEMENT SCHEDULE

Description AM Noon PM Night Comments
PRO-C™ and/or Ultimate Protector 2 caps 2 caps 2 caps Take with meals or with snack.
Bone Guardian 3 tabs 3 tabs Take with meals.
Mighty Multi-Vite! or
Multi Two — Multivitamins
2 caps or
1 tab
2 caps or 1 tab Take with meals.
Essential Fats plus E 1 softgel 1 softgel 1 softgel Take with meals.
PROLYT – Proteolytic Enzyme Formula 2 caps 2 caps 2 caps 2 caps Take between meals.
Buffered Vitamin C, Tablets — 1,000 mg (1 gm) or Powder (1/4 tsp = 1 gm) 2 tabs or
1/2 tsp
2 tabs or
1/2 tsp
2 tabs or 1/2 tsp 2 tabs or 1/2 tsp Best with meals, but other times are okay. Start with 2 tabs or 1/2 tsp twice per day and add another 2 tabs or 1/2 tsp every few days until you are taking 8 tabs or 2 tsp per day.
Vitamin D3 Plus – 5,000 IU 1 softgel 1 softgel Take with meals. Reduce to 1 softgel after 2 months.
Joint Health Formula 2 caps 2 caps 2 caps Take between meals and away from Bone Guardian.
Magnesium Oil 10 pumps 10 pumps 10 pumps 10 pumps Spray on affected area – or nearby area.
Rejuvenate! Plus or
Rejuvenate! (original)
1 scoop 1 scoop Take as a meal by itself or with fruit/berries.

ADDITIONAL NUTRIENTS

Additional nutrients that may be helpful include Warrior Mist™ for pain relief (rub on adjacent area several times daily), Echinacea (as drops or capsules), N-Acetyl-L-Cysteine – NAC (2 gms per day), Progesterone Cream (1/4–1/2 tsp twice daily), Prescript-Assist™ (2 capsules daily) or Poly-Dophilus capsules (3 caps, 3 times per day 10 minutes before meals) if on antibiotics.

PROPER DIET IS ESSENTIAL

Consume a diet that provides good amounts of protein and relatively low in fat. Eat only lean meats, poultry and fish (e.g., sardines, salmon, mackerel) in the amount of a 5–10 ounces per day). Ensure a good intake vegetables, including high levels of dietary fiber. Drink 16 oz per day of fresh vegetable juices from carrot, celery, beets, cabbage, etc.

Other healthy foods include fruits, whole grains (e.g., brown rice, millet, and quinoa), beans, nuts and seeds (sunflower, chia, flax, pumpkin, almond, walnut and sesame in small amounts — 2 or 4 ounces — are good). Try eating Hank’s Vegetable Soup several times a week. Avoid all sweets (sugar), processed/refined foods (white bread and pasta), preservatives, and artificial flavors and colors. Vary your diet.

HYDROTHERAPY

An additional treatment that can be useful is hydrotherapy. In particular, hot and cold showers are a very effective way to move the blood and create circulation. This can speed up both detoxification and delivery of healing nutrients to the area of a bone fracture. Here’s how to do this. Once daily, take a complete hot and cold shower. You will start with hot water for one minute, then cold for one minute. Repeat this seven (7) times so the shower should last about 15 minutes.

Another time, daily, you can perform a complete hot and cold shower routine again or a partial one just applying the water directly to or near the area where there is a bone fracture. While you are doing both hot and cold showers, pay special attention to any affected area and massage it as vigorously as is safe and comfortable. If a shower is impossible, then alternate hot packs and ice packs on the area of the bone fracture.

CONCLUSION

By following the recommendations and suggested supplement schedule, healing time for bone fractures should be significantly reduced and fractures will heal more completely with fewer complications. By ensuring your body receives the proper nutrients it needs to heal itself, and by engaging in other relevant practices (e.g., hydrotherapy), you and/or your loved ones can heal bone fractures successfully, and continue a healthy, vibrant lifestyle.

ADDITIONAL RESOURCES

HPDI REJUVENATION PROGRAM

REJUVENATION PROGRAM PART 6 (INCLUDES HYDROTHERAPY)

REJUVENATE!™ SUPERFOODS

ULTIMATE PROTECTOR™

“FRED’S FAVORITE VEGETABLE JUICE RECIPE: ‘THE DOCTOR'”

2

Vitamin D3 – “SUPERSTAR”!

Dr. Hank Liers, PhDVitamin D3 is emerging into a “SUPERSTAR” of nutrition with more published papers about it than any other vitamin.

According to PubMed.gov, in 2012 there were 3600 publications with vitamin D in the title or abstract — more than for any other vitamin. This brings the total number of publications on vitamin D listed by PubMed to 33,800. This total compares to 35,100 on vitamin C or ascorbic acid, 21,700 on vitamin E, 19,100 on vitamin A, 17,600 on folate, and 12,000 on vitamin B12.

Vitamin D thereby has become the most popular vitamin, even though strictly speaking it is not a vitamin. Technically, it is an essential hormone that can be made in the body via the action of ultraviolet B (UVB) light. It can also be obtained orally via diet or supplements.

THINGS TO KNOW ABOUT THIS SUPERSTAR NUTRIENT

• In a world of sun avoidance, sun blocks, working indoors, latitudinal effects, etc., nearly the entire population suffers in multiple ways from Vitamin D3 deficiency.

• Dermatological associations in the US and some other countries have a “zero” sun-exposure policy. This shows how far they lag behind current research. Although Vitamin D supplementation is ideal in winter, in other months, a certain amount of sunshine on skin allows the body to generate its own Vitamin D3 naturally!

• Inadequate Vitamin D3 is associated with osteoporosis, poor immunity, autoimmune diseases, diabetes, hypertension, cancers, susceptibility to flu, neurological problems, autism, depression, chronic pain, periodontal disease, muscle weakness, birth defects, and other conditions.

• Human beings optimally produce 10,000–20,000 IU of Vitamin D3 (cholecalciferol) when exposed to full sunlight on a significant portion of skin for about 30 minutes.

• The body starts to gain the full benefits of Vitamin D3 only after it produces (or intakes orally) about 5,000 IU Daily.

• Vitamin D3 is a prehormone with powerful effects and with few exceptions cannot be obtained in sufficient amounts from diet.

• Vitamin D3 can be described as a “superstar” because indirectly it comes from our solar system star…the sun!

VITAMIN D DEFICIENCY IS EPIDEMIC WORLDWIDE

Vitamin D deficiency currently is a worldwide epidemic with more than one billion people at risk for diseases associated with low Vitamin D status. Vitamin D is proven safe and effective for a wide range of health conditions (see above and below). There are various reasons for this epidemic, including a significant portion of the world’s population living in northerly latitudes (where sunlight is inadequate during many months of the year), sun avoidance, time spent indoors, etc.

WHAT IS VITAMIN D3 PLUS?

VITAMIN D3 PLUS is an advanced Vitamin D formula providing high-dose Vitamin D3. Vitamin D3 is the natural form of Vitamin D produced in the body from sunlight and is the form best used for therapeutic purposes.

One softgel capsule of Vitamin D3 Plus provides 5,000 IU of Vitamin D3 derived from highly purified and molecularly distilled fish liver oils. In addition, the product contains 1,000 IU of Vitamin A also derived from highly purified and molecularly distilled fish liver oils and 10 mcg of Vitamin K2 from menaquinone-7.

RECOMMENDATIONS FOR SUPPLEMENTING WITH VITAMIN D3 PLUS

Recent research on Vitamin D suggests that most people will benefit from 5,000 IU of Vitamin D3 daily (unless there is some constraining lifestyle factor or medical reason). Due to its long half-life (about 30 days) in the body, Vitamin D can be taken effectively in smaller doses if needed (e.g., 5,000 IU taken fewer times per week). For example, taking one capsule once per week would give a daily equivalent dose of about 714 IU (i.e., 5,000 IU divided by seven days).

Additional important nutrients you need to take with Vitamin D3 in order to achieve maximum benefits include magnesium, calcium, zinc, and boron. These additional nutrients are included in our foundational supplements (multivitamins, essential fats, Vitamin C formulas, and Rejuvenate!™ superfoods) and bone formulas (Bone Jour!™and Bone Guardian).

NUTRITIONAL FACTS REGARDING HPDI’S VITAMIN D3 PLUS 

The liver and kidney help convert vitamin D to its active hormone form. The major biologic function of Vitamin D is maintaining normal blood levels of calcium and phosphorus. Vitamin D aids in the absorption of calcium, helping to form and maintain strong bones. It promotes bone mineralization in conjunction with a number of other vitamins, minerals (especially magnesium), and hormones. While adequate sun exposure is an ideal means to obtain Vitamin D, most of the population cannot obtain sufficient sunlight during fall and winter months to maintain optimal Vitamin D levels. HPDI’s Vitamin D3 Plus offers a solution for keeping Vitamin D levels healthy…so you can be your healthiest!

When there is insufficient Vitamin D in the body, bones can become thin, brittle, soft, or misshapen. Vitamin D prevents rickets (in children) and osteomalacia (softening of bones) (in adults). These skeletal diseases result in defects that can severely weaken bones. It is estimated that over 25 million adults in the United States either have developed osteoporosis or are at risk of developing it. Osteoporosis is a disease characterized by fragile bones. It results in increased risk of bone fractures. Vitamin D deficiency was recognized as the cause of rickets and osteomalacia 75 years ago. The prevention and cure of these diseases with fish liver oil was a triumph for nutritional science and since then the body’s requirement for Vitamin D has been linked to these conditions. 

Vitamin D deficiency also has been associated with greater incidence of hip fractures. In older women, a higher Vitamin D intake from diet and supplements is associated with less bone loss. Vitamin D supplementation therefore may help prevent fractures resulting from osteoporosis and the loss of bone. Vitamin D supplements offer a significant means for strengthening bones and skeletal structures, and for preventing bone weakness or bone loss leading to osteomalacia, osteoporosis, and other conditions related to weak bones.

Vitamin D affects major aspects of human health beyond its classical role in mineral metabolism. It is well established that the active form of Vitamin D acts an effective regulator of cell growth and differentiation in a number of different cell types, including cancer cells. Laboratory, animal, and epidemiologic evidence strongly suggest that Vitamin D may be protective against some cancers. Clinical studies now show Vitamin D deficiency to be associated with four of the most common cancers: breast cancer, prostate cancer, colon cancer, and skin cancer. The active form of Vitamin D plays a critical role in supporting optimal health!

VITAMIN A AND VITAMIN K2 WORK TOGETHER WITH VITAMIN D

It is important to understand that Vitamin A works together with Vitamin D and Vitamin K2 to maintain healthy bones. Vitamin D has been shown to prevent Vitamin A toxicity. VITAMIN D3 PLUS includes Vitamin A because Vitamin A and Vitamin D work together to create excellent health!

Vitamin K2 in the form of MK-7 has been shown in numerous studies to extract calcium from the blood and arteries and deposit calcium into growing or aging bones. In addition, MK-7 appears to have the potential to prevent or even reverse some forms of heart disease and, at the same time, do the same for bone loss. It is believed that patients would be able to be treated with doses of vitamin D that possess greater therapeutic value than those currently being used while avoiding the risk of adverse effects by administering Vitamin D together with Vitamins A and K2. Vitamin D3 Plus includes Vitamin K2 (as MK-7) because MK-7 provides unique benefits for health that complement the benefits offered by Vitamin D…and because they act synergistically to provide other benefits beyond the benefits each provides by itself!

RECENT RESEARCH STUDIES ON VITAMIN D

Orthomolecular Medicine News Service recently released the top 16 Vitamin D papers of 2012. These are summarized below.

4,000 IU vitamin D3 was of great help during pregnancy

A topic that generated considerable interest this year was the role of vitamin D during pregnancy. In a pair of papers, researchers from the Medical University of South Carolina discussed the findings and implications of their randomized controlled trial of vitamin D supplementation during pregnancy [Hollis et al., 2012; Wagner et al., 2012]. Over 300 women were enrolled in the study. Women were assigned to take supplements containing 400, 2000, or 4000 IU/d vitamin D3 or a placebo. No adverse effects were found such as hypercalcemia or hypercalcuria. This study found that it took 4000 IU/d to raise serum 25-hydroxyvitamin D [25(OH)D] levels to about 40 ng/ml (To convert to nmol/l, multiple ng/ml by 2.5.), a nearly optimal level of 1,25-dihydroxyvitamin D. 1,25-dihydroxyvitamin D is the active or hormonal metabolite of vitamin D which among other things controls the expression of several hundred genes. (See Hossein-nezhad and Holick [2012] for a summary of the effects of vitamin D on fetal development.) In the study, those taking the higher vitamin D doses had significantly reduced risk of primary Cesarean section delivery and pre-eclampsia. Other adverse pregnancy outcomes occur with vitamin D deficiency such as premature delivery and low birth weight, but too few women were enrolled in this study to find statistically significant results on these conditions.

Mounting evidence that vitamin D deficiency is an important risk factor for autism

A study from Saudi Arabia examined the relation between serum 25(OH)D level and anti-myelin-associated glycoprotein (anti-MAG) auto-antibodies in autistic children near the age of eight years [Mostafa and Al-Ayadhi, 2012]. There was a very strong inverse relation between the two levels (r = -0.86, p<0.001). The serum 25(OH)D levels in autistic children averaged 19 ng/ml, while that for healthy children averaged 33 ng/ml. Both autistic and healthy children had about six hours of sun exposure per week. The reason that MAG is relevant to autistic children is that MAG is a compound that promotes regeneration of young neurons. Anti-MAG auto-antibodies appear to play a role in some autoimmune disorders relating to neurons through attacking cells that maintain a healthy nervous system. Serum anti-MAG auto-antibodies are strongly related to autism measured with the Childhood Autism Rating Scale. This provides very strong evidence that vitamin D deficiency is associated in some way with autism. Whether increasing serum 25(OH)D levels for those with autism reduces the symptoms of autism remains to be determined.

Low vitamin D during pregnancy is associated with childhood language impairment

A study in Perth, Australia measured serum 25(OH)D levels at 18 weeks into pregnancy, and then measured language impairment of the offspring at 5 and 10 years of age. It found that women with serum 25(OH)D levels below 18 ng/ml had children with twice the risk of clinically significant language difficulties compared to those with 25(OH)D levels above 28 ng/ml. Exactly why is not currently known, but there are many possibilities. It is noted that in the United States in the early 2000s, white women of childbearing age had mean 25(OH)D level of 26 ng/ml while black women of childbearing age had mean 25(OH)D level of 14 ng/ml. Both of these levels are low by current standards. As explained below, skin color is directly relevant to serum vitamin D levels produced by exposure to sunlight.

Higher vitamin D is associated with lower all-cause mortality rates

A topic of interest at the other end of life was the relation of mortality rate to serum 25(OH)D levels. A meta-analysis of 11 observational studies and 60,000 individuals found a reduction in risk over about 10 years for highest vs. lowest category of 25(OH)D level of mortality of 29% [Zittermann et al., 2012]. Comparing graded levels of intake, the reduction in risk was 14% for an increase of 5 ng/ml, 23% for an increase of 10 ng/ml, and 39% for an increase of 20 ng/ml in plasma levels of 25(OH)D, starting from a median of ~11 ng/ml. The participants starting with the lowest levels of serum 25(OH)D received the greatest benefits. Those who started with higher serum levels, closer to optimal (30-40 ng/ml), received less benefit from additional vitamin D. This relation between starting serum 25(OH)D levels and health outcome is not surprising because it is similar to many other health studies. Since 25(OH)D levels likely changed over the duration of the studies, and some participants died of unrelated causes, the actual effect of serum 25(OH)D level on mortality rate is greater than these estimates.

And less cardiovascular disease

Cardiovascular disease is an important contributor to mortality rates. A study of 11,000 patients in Kansas was reported. The patients had a mean age of 58±15 years, a body mass index of 30±8 kg/m2, and a mean serum 25(OH)D level of 24±14 ng/ml [Vacek et al., 2012]. Serum 25(OH)D levels below 30 ng/ml was significantly associated with several cardiovascular-related diseases, including hypertension, coronary artery disease, cardiomyopathy, and diabetes. After a period of 5.5 years, those with serum 25(OH)D levels below 30 ng/ml had twice the mortality rate of those with higher 25(OH)D levels.

And less risk of diabetes mellitus type 2

In a 2.7-year study of 2000 prediabetics, participants with the highest third of 25(OH)D levels (median, 30.1 ng/ml) had a reduction in risk of 28% for developing diabetes mellitus type 2 compared with participants in the lowest third (median, 12.8 ng/ml) [Pittas, 2012].

. . . and less diabetes mellitus type 1 (T1DM)

An observational study on insulin-dependent diabetes mellitus (T1DM) was based on 1000 U.S. military service personnel who developed this disease between 2002 and 2011 [Gorham et al., 2012]. They had provided blood samples between one and ten years prior to developing T1DM. They were carefully matched with another thousand service personnel who did not develop T1DM. There was a reduction in risk of 78% for developing T1DM for those with serum 25(OH)D levels above 24 ng/ml compared to those with levels above 24 ng/ml. This finding is highly statistically significant and is one of the strongest studies of its type.

Fewer bacterial and viral infections

The effect of vitamin D in reducing risk of infections is a topic of increasing interest. Vitamin D reduces risk of infections primarily by strengthening the innate immune system, primarily by inducing production of cathelicidin, a polypeptide with antimicrobial and antiendotoxin properties. It also shifts production of cytokines, a type of cell signaling molecule, away from proinflammatory ones, and has a number of other actions on both the innate and adaptive immune system [Lang et al., 2012]. While the effects of vitamin D have been found mostly for bacterial infections, some have also been reported for viral infections such as influenza, HIV, and hepatitis C [Lang et al., 2012]. In a supplementation study in Sweden involving 140 patients with frequent respiratory tract infections (RTIs) using 4000 IU/d vitamin D3, those in the supplementation group increased their serum 25(OH)D level to 53 ng/ml while those in the placebo group had levels near 27 ng/ml [Bergman et al., 2012]. Those taking vitamin D3 had a 23% reduction in RTIs and a 50% reduction in the number of days using antibiotics.

The benefits of vitamin D in reducing risk of cancer

One of the important and well-documented effects of vitamin D is reduced risk of cancer and increased survival after cancer diagnosis. There were 400 publications on vitamin D and cancer in 2012 according to PubMed.gov. Evidence from ecological, observational and laboratory studies have identified over 15 types of cancer for which higher solar UVB light and/or serum 25(OH)D levels are associated with reduced risk. Two of the papers are especially noteworthy. One, a study from Norway involving 658 patients with either breast, colon, lung, or lymphoma with serum 25(OH)D levels determined within 90 days of cancer diagnosis were followed for up to nine years [Tretli et al., 2012]. Compared to those with levels <18 ng/ml, those who originally had levels >32 ng/ml had a reduction in risk for dying from cancer of 66%. To a cancer patient, this would be a lifeline.

Another cancer paper reported the results of supplementation with 4000 IU/d vitamin D3 of those with low-grade biopsy-assayed prostate cancer [Marshall et al., 2012]. Forty four patients successfully completed the one-year study. Twenty four of the subjects (55%) showed a decrease in the amount of cancer; five subjects (11%) showed no change; 15 subjects (34%) showed an increase. In comparison, with a historical group of 19 patients, only 4 (21%) had reductions in the amount of cancer, 3 (16%) showed no changes, and 12 (63%) showed an increase in cancer. Thus optimal vitamin D supplementation appears to be useful for treating those with cancer.

Falls and fractures

The classical role of vitamin D is to regulate calcium and phosphate absorption and metabolism, leading to strong bones. A pooled analysis of 31,000 persons (mean age, 76 years; 91% women) participating in randomized controlled trials of vitamin D supplementation who developed ~1000 incident hip fractures and ~3800 nonvertebral fractures found that those with the highest intake (median 800 IU/d; range 792-2000) had a 30% reduction in risk of hip fracture and a 14% reduced risk of nonvertebral fracture [Bischoff-Ferrari et al., 2012]. The role of vitamin D in neuromuscular control also plays an important role in reducing risk of falls and fractures.

Skin pigment adapts slowly to changed ultraviolet environment

Jablonski and Chaplin have published a series of papers on human skin pigmentation and its relation to solar ultraviolet radiation (UVR) [Jablonski and Chaplin, 2012]. Their primary thesis is that human skin pigmentation has adapted to UVR conditions where a group of people live for 50 generations, or about a thousand years. UVR from mid-day sunlight produces vitamin D, which provides important protection against many diseases, but sunlight also causes skin cancer and destruction of folate. Dark skin protects against free radical production, damage to DNA, cancer, and loss of folate. Thus, dark skin is best in the tropical planes regions while pale skin is best at high latitude regions. Those with skin adapted to UVB between 23° and 46° have the ability to tan, which is an adaptation to seasonal changes in solar UVB doses. However, in recent times, people have moved or traveled to regions where their skin pigmentation is not suited to the local UVR conditions. They discuss three examples: nutritional rickets, multiple sclerosis and melanoma. Their abstract concludes with this observation: “Low UVB levels and vitamin D deficiencies produced by changes in location and lifestyle pose some of the most serious disease risks of the twenty-first century.”

Vitamin D levels for traditionally living Africans

A study on traditionally living Africans near the equator provides information on “normal” 25(OH)D levels. A paper was published on serum 25(OH)D levels of the Masai and the Hadzabe living near 4° S in Tanzania [Luxwolda et al., 2012]. They have skin type VI (very dark), wear a moderate amount of clothing, spend the major part of the day outdoors, but avoid direct exposure to sunlight when possible. The mean serum 25(OH)D levels of Maasai and Hadzabe were 48 (range 23-67) ng/ml and 44 (range 28-68) ng/ml, respectively. This finding suggests that serum 25(OH)D levels in the range of 40-50 ng/ml may be optimal for human health, which is generally consistent with observational studies for a number of health outcomes.

Vitamin D is made by exposure to sunlight to a significant degree only when the sun is 45 degrees or more above the horizon. At the latitudes of North America and Europe, this is summer midday sunlight between the hours of 11 a.m. and 3 p.m. In the early morning or late afternoon, light-skinned individuals may tan but they hardly get any vitamin D from sunlight. And in the winter, nobody gets much vitamin D from the sun. This explains the health benefits of taking supplements of vitamin D.