Dr. Hank Liers, PhD bone fracturesSeveral years ago a customer asked me for a program that could be helpful to those suffering with bone fractures. A relative had been diagnosed with multiple bone fractures in his ankle.

Since I have been counseling individuals regarding natural treatments for supporting those with bone fractures and injury for many years, I was able to provide a comprehensive program that could be helpful in recovery. More recently, we have introduced products and tools that can be even more supportive. Therefore, in this article we are providing an update to the bone fractures program.

Clearly, the need for such a program is great. According to the American Academy of Orthopaedic Surgeons (AAOS), about six million individuals suffer fractures each year in North America. In about 5–10 percent of cases, patients suffer either delayed healing or fractures that do not heal.

The problem of bone fractures is especially troubling for the elderly, many of whom suffer from osteoporosis, a condition in which bones become weak and break more easily. For an older person, a fracture affects quality of life because it significantly reduces function and mobility, and requires an extended period of recuperation.

The bone fracture program set forth below also works well to support the healing of other types of bone problems, including broken bones, bone surgery, osteoporosis, and wisdom tooth removal.



The first element of the program consists of Foundational Supplements. This group of supplements ensures the body is being supplied with all of the basic elements needed for optimal function. The primary foundational supplements consists of 1) a therapeutic multivitamin and mineral formula, 2) a complete buffered Vitamin C with antioxidants formula, 3) an essential fatty acids supplement, and 4) a high-RNA superfoods formula.

Our Foundational Supplements are described in great detail on the HPDI website where we provide a free downloadable e-book “The Need for Foundational Supplements” (.pdf). Suffice it to say that the foundational supplements are a essential part of the program that ensure healing will take place quickly and effectively. I encourage everyone to become familiar with this information as foundational supplements are basic to any wellness or healing program.

bone fractures


The second element of the program for healing bone fractures consists of Enhancement Formulas that strengthen the body as it relates to dealing with the damaging effects of bone fractures. These include a Vitamin D3 formula with the synergistic nutrients of Vitamin A and Vitamin K2 that are required for the rebuilding of bone as well as strengthening the body in many other ways. The HPDI Vitamin D3 Plus formula to designed to specifically address this need.

A second Enhancement Formula in this program is our comprehensive Bone Guardian formula that is based upon micronized veal bone that provides hydroxyapatite (Ca10(PO4)6(OH)2). Hydroxyapatite is the basic component of human bone that is 50% by volume and 70% by weight. Whereas the Vitamin D3 Plus formula builds the bone matrix, the Bone Guardian fills in the matrix with materials such as calcium, phosphorus, magnesium, boron, zinc, manganese, copper, silica, and strontium. HPDI sells Bone Guardian in both the tablet and capsule forms. The capsule form may be better for older people who are able to absorb capsules better than tablets.

A third Enhancement Formula to the program is additional amounts of Vitamin C. Vitamin C is known to participate in every step of the process of building collagen, which is a key component of bone. Vitamin C has been shown to increase bone mass density. We recommend slowly increasing your intake of buffered Vitamin C until you reach your bowel tolerance. This can be accomplished by increasing your intake of HPDI’s foundational supplement PRO-C™ formula. The PRO-C has the added value of containing oligomeric proanthocyanidins (OPCs) from grape seed, skin, & pulp. OPCs in the body are able to strongly crosslink and strengthen new and damaged collagen fibers needed needed to repair bones, ligaments, tendons, and cartilage.


The third element in the program are Specific Condition Formulas that directly address issues related to bone fractures. The first of these is the addition of a joint formula that allows the body to build and repair connective tissue and to significantly reduce inflammation in the area of bone fractures. In most cases of fractures there will be damaged ligaments and tendons as well as inflammation in the area.

HPDI’s Joint Health Formula includes the ingredients glucosamine hydrochloride, MSM, and sea cucumber (a significant source of chondroiten sulfate) in addition to anti-inflammatory substances such as turmeric extract, rutin, and grape extract (seed, pulp, and skin) that have been extremely helpful in both repairing connective tissue and reducing pain and inflammation.

A second strongly recommended condition-specific formula is proteolytic enzymes. Because it is highly likely in the case of bone fractures and injury that there is significant tissue damage, a formula with pancreatic and plant enzymes as well as anti-inflammatories can be extremely helpful is clearing out the damaged tissue. This gives the body the opportunity to begin the rebuilding process much sooner.

Our recommended PROLYT formula contains the proteolytic enzymes bromelain, trypsin (pancreatic enzyme), and chymotrypsin (pancreatic enzyme), and the polyphenols/bioflavonoids turmeric extract (95% curcuminoids), quercetin and oligomeric proanthocyanidins (OPCs) from grape extract. This formula when taken on an empty stomach between meals is quickly absorbed into the bloodstream and goes to work cleaning up any damaged tissues in the area surrounding a fracture and assists in reducing pain and inflammation.


A final Specific Condition Formula that I highly recommend for healing bone fractures is to rub Ancient Minerals Magnesium Oil on and surrounding the fracture area. Bones cannot heal without having adequate amounts of magnesium available. Unfortunately, many people are deficient in magnesium and even taking oral magnesium cannot easily provide sufficient amounts to an area with a bone fracture. Magnesium oil (mostly magnesium chloride) is quickly absorbed transdermally (via skin) and often can provide rapid healing and pain relief!


The processed food diets with a high protein and low vegetable content consumed by many people in the U.S. and elsewhere often produce conditions in the body of acidity. This in turn leads to decreased oxygenation of cells and encourages a greater amount of anaerobic processes in metabolism. In addition, when the body is acidic calcium can be taken from bones in order to balance the acidity. This can lead to poor healing of bone fractures.

In order to counter acidic conditions in the body we recommend the use of HPDI’s pH ADJUST formula. As a dietary supplement, take 1 gm (about a rounded ¼ tsp) in 4-8 ounces of purified water preferably away from food, or as directed by a health care professional.  For extremely acidic conditions, try 4–10 doses per day, depending on acidity level. Use pH paper to ensure pH levels remain balanced, and do not become too alkaline (alkalosis may occur above pH 8.2).

TESTING pH LEVELS: The best way to test pH levels is to use litmus paper, which HPDI offers in rolls (Hydrion brand) for this purpose. You can test salivary or urinary pH. In order to test salivary pH, simply use a small strip of pH paper to dip into a small amount of saliva. Advantages of pH paper include rapid results, ease of use, and cost effectiveness.

pH Paper bone fractures protocol

The color of the litmus paper indicates the pH level of the body fluid tested. Most litmus paper comes with an indicator chart showing colors corresponding to various pH levels. Alkaline states will generally produce a dark green, blue or purple color (most basic). Acidic states will range from yellow (most acidic) to light green.

Salivary pH and urinary pH are significantly affected by recent food consumption and other factors, so it it best to test pH hours after meals or in the morning when you awake. We prefer to measure urinary pH since results are more consistent. Measuring urinary pH is a simple as placing a few drops of urine on the paper or dipping the paper into a sample cup of fresh urine.

A consistent pH measurement of less than 7.0 indicates that you are too acidic (values less than 6.2 show extreme acidity). This indicates that you should consume more alkaline forming foods (usually vegetables) and/or take pH ADJUST. A single dose of pH ADJUST can change conditions in the body from acidic to alkaline within a few hours.


The VDR gene (contained in every cell of the body) provides instructions for making a protein called vitamin D receptor (VDR), which allows the body to respond appropriately to vitamin D. This vitamin can be acquired from foods in the diet or made in the body by exposure to from sunlight. Vitamin D is involved in maintaining the proper balance of several minerals in the body, including calcium and phosphate, which are essential for the normal formation of bones and teeth. One of vitamin D’s major roles is to control the absorption of calcium and phosphate from the intestines into the bloodstream. Vitamin D is also involved in several process unrelated to bone formation.

VDR attaches (binds) to the active form of vitamin D, known as calcitriol. Calcitrol is produced in the body from Vitamin D3 (cholecalciferol) in the liver and kidneys. The interaction with calcitriol allows VDR to partner with another protein called retinoid X receptor (RXR). The resulting complex of proteins then binds to particular regions of DNA, known as vitamin D response elements, and regulates the activity of vitamin D-responsive genes. By turning these genes on or off, VDR helps control calcium and phosphate absorption and other processes.

In recent years, genetic tests have become available that show VDR variations can cause serious conditions related to low bone density and other important body functions such a higher blood glucose levels or lower immune system function. If a person is having little success in healing bone fractures, it is possible that VDR variations are a key factor of causation.

In such cases, we recommend having genetic testing done to determine if VDR variations are present. Recently, HPDI has teamed with a genetic testing company (BodySync, Inc.) and sells the BodySync test kits on our Reseller site. Please click here to see our blog article regarding the BodySync genetic test. Among the genes tested for in the test are three variations of the VDR gene. Resellers can purchase the test kits directly from HPDI and retail customers can call us  (800-228-4265) to find out how we can help them get a test kit and support them with any associated counseling regarding the results.


I have included all of the above supplements including recommended dosages plus more related to having an excellent diet in the table provided below.

Description AM Noon PM Night Comments
PRO-C 2 caps 2 caps 2 caps Take with meals or with snack.
Bone Guardian 

Bone Guardian Caps (easier to absorb)

3 tabs

3 caps


3 caps

3 tabs

3 caps

Take with meals.

Take with meals.

Mighty Multi-Vite! or
Multi Two — Multivitamins
2 caps or
1 tab
2 caps or
1 tab
Take with meals.
Essential Fats plus E 2 softgel 2 softgel 2 softgel Take with meals.
PROLYT – Proteolytic Enzyme Formula 2 caps 2 caps 2 caps 2 caps Take between meals.
Buffered Vitamin C, Tablets — 1,000 mg (1 gm) or Powder (1/4 tsp = 1 gm) 2 tabs or
1/2 tsp
2 tabs or
1/2 tsp
2 tabs or 1/2 tsp 2 tabs or 1/2 tsp Best with meals, but other times are okay. Start with 2 tabs or 1/2 tsp twice per day and add another 2 tabs or 1/2 tsp every few days until you are taking 8 tabs or 2 tsp per day.
Vitamin D3 Plus 5,000 IU 1 softgel 1 softgel Take with meals. Reduce to 1 softgel after 2 months.
Joint Health Formula 2 caps 2 caps 2 caps Take between meals and away from Bone Guardian.
Magnesium Oil 10 pumps 10 pumps 10 pumps 10 pumps Spray on affected area – or nearby area.
Rejuvenate! Plus or
Rejuvenate! (original)
1 scoop 1 scoop Take as a meal by itself or with fruit/berries.


Additional nutrients that may be helpful include pH ADJUST (to balance excess acidity in the body),  Warrior Mist™ for pain relief (rub on adjacent area several times daily), Echinacea (as drops or capsules), N-Acetyl-L-Cysteine – NAC (2 gms per day), Progesterone Cream – for women (1/4–1/2 tsp twice daily), and Prescript-Assist™ probiotics (2 capsules daily) if on antibiotics.


Consume a diet that provides good amounts of protein which is needed by the body to support the healing of bone fractures. Eat meats, poultry and fish (e.g., sardines, salmon, mackerel) in the amount of a 5–10 ounces per day. Ensure a good intake of organic vegetables, including high levels of dietary fiber. Drink 16 oz per day of fresh vegetable juices from carrot, celery, beets, cabbage, etc.

Other healthy foods (preferably organic) include fruits, whole grains (e.g., brown rice, millet, and quinoa), beans, nuts and seeds (sunflower, chia, flax, pumpkin, almond, walnut and sesame in small amounts — 2 or 4 ounces — are good). Try eating Hank’s Vegetable Soup several times a week. Avoid all sweets (sugar), processed/refined foods (white bread and pasta), preservatives, and artificial flavors and colors. Vary your diet.


An additional treatment that can be useful is hydrotherapy. In particular, hot and cold showers are a very effective way to move the blood and create circulation. This can speed up both detoxification and delivery of healing nutrients to the area of a bone fracture. Here’s how to do this. Once daily, take a complete hot and cold shower. You will start with hot water for one minute, then cold for one minute. Repeat this seven (7) times so the shower should last about 15 minutes.

Another time, daily, you can perform a complete hot and cold shower routine again or a partial one just applying the water directly to or near the area where there is a bone fracture. While you are doing both hot and cold showers, pay special attention to any affected area and massage it as vigorously as is safe and comfortable. If a shower is impossible, then alternate hot packs and ice packs on the area of the bone fracture.


By following the recommendations and suggested supplement schedule, healing time for bone fractures can be significantly reduced and fractures may heal more completely with fewer complications. By ensuring your body receives the proper nutrients it needs to heal itself, and by engaging in other relevant practices (e.g., hydrotherapy), you and/or your loved ones may be able to deal with bone fractures successfully, and continue a healthy, vibrant lifestyle.









Doctor Hank Liers PhD vitamin c ascorbic acid antioxidant collagen support immunityPeriodically, it is beneficial for me to present a review of accumulated scientific knowledge regarding key nutrients and remind readers of their importance.

In this article, I will review some of the research and clinical findings on vitamin C that have been gathered over the past 70 years. As you will see, vitamin C is an amazing nutrient!


Vitamin C typically is called l-ascorbic acid or ascorbate and is an essential nutrient for humans and other animal species. The term “vitamin C” refers to a number of vitamins that have vitamin C activity in animals, including ascorbic acid and its salts (e.g., magnesium ascorbate, calcium ascorbate, sodium ascorbate, etc.), and some oxidized forms such as dehydroascorbic acid.

Vitamin C is a cofactor in at least eight enzymatic reactions, including several collagen syntheses reactions that when dysfunctional (usually because of lack of Vitamin C) cause the most severe symptoms of scurvy.  In animals, these reactions are especially important in wound healing and in preventing bleeding from capillaries.

Ascorbate acts as an electron donor and/or hydrogen donor, and this ability makes it a potent antioxidant. It rapidly reduces superoxide and nitroxide radicals and scavenges hydroxyl, alkoxyl, and peroxyl radicals. It also reacts with non-radical species such as singlet oxygen and hypochlorous acid. It has been observed in in vitro experiments that Vitamin C acts as the first line of defense in the plasma.

vitamin c fruits citrus

Fruits high in vitamin C include citrus, strawberries, and kiwi

Vitamin C can “recycle” other antioxidants (i.e., due to its function as an electron donor) and thereby allow these antioxidants to quench more free radicals. Also, the one- and two- electron forms of vitamin C, semidehydroascorbic acid and dehydroascorbic acid, respectively, can be reduced in the body by glutathione and NADPH-dependent enzymatic mechanisms. The presence of glutathione in cells and extracellular fluids helps maintain ascorbate in a reduced state.

The vast majority of animals and plants are able to synthesize vitamin C, through a sequence of enzyme-driven steps. However, some animals, including guinea pigs and humans, lack the enzyme that is required in the last step of vitamin C synthesis. These species are able to survive with the lower levels available from their diets by recycling oxidized vitamin C. Animals that have the enzyme needed to synthesize of vitamin C do not have the ability to recycle oxidized vitamin C.

Ascorbic acid is absorbed in the body by both active transport and simple diffusion. Sodium-Dependent Active Transport—Sodium-Ascorbate Co-Transporters (SVCTs) and Hexose transporters (GLUTs)—are the two transporters required for absorption. SVCT1 and SVCT2 import the reduced form of ascorbate across plasma membrane. GLUT1 and GLUT3 are the two glucose transporters, and transfer only the dehydroascorbic acid form of Vitamin C.

Although dehydroascorbic acid is absorbed at a higher rate than ascorbate, the amount of dehydroascorbic acid found in plasma and tissues under normal conditions is low, as cells rapidly reduce dehydroascorbic acid to ascorbate. I have used this fact to advantage by incorporating dehydroascorbic acid in several of the products I have formulated (Ultimate Protector™ and Synergy C). This approach allows for greater absorption and retention of vitamin C in the body.

Vitamin C Products at integratedhealth.com

Ascorbate concentrations in the blood above the kidney (renal) re-absorption threshold pass freely into the urine and are excreted. At high dietary doses, ascorbate is accumulated in the body until the plasma levels reach the renal resorption threshold, which is about 1.5 mg/dL in men and 1.3 mg/dL in women. Concentrations in the plasma larger than this value are excreted in the urine with a half-life of about two hours.

Although the body’s maximal stores of vitamin C are to some extent determined by the renal threshold for blood, there are many tissues that maintain vitamin C concentrations far higher than in blood. Biological tissues that accumulate over 100 times the level in blood plasma of vitamin C are the adrenal glands, pituitary, thymus, corpus leuteum, and retina. Tissues with 10–50 times the concentration present in blood plasma include the brain, spleen, lung, testicle, lymph nodes, liver, thyroid, small intestinal mucosa, leukocytes, pancreas, kidney, and salivary glands.

Historically, the discovery of vitamin C was related to the findings that a substance in citrus fruits (and other fresh foods) was able to prevent scurvy. In the early 1930s research teams in Hungary (led by Albert Szent-Georgi) and Pittsburgh, Pennsylvania USA (led by Charles Glen King) first identified the anti-ascorbutic factor. Szent-Georgi initially called it l-hexuronic acid, but later proposed that the substance L-hexuronic acid be called “a-scorbic acid,” and chemically “L-ascorbic acid,” in honor of its activity against scurvy.

Shortly thereafter (around 1934), the Polish chemist Tadeus Reichstein succeeded in synthesizing the vitamin in bulk. The process made possible the cheap mass-production of vitamin C, which was quickly marketed by the Hoffman-La Roche company. Even today, all industrial methods for the production of ascorbic acid are based on the Reichstein process.

The Reichstein process involves using microbial fermentation of sugar derived mainly from corn, potatoes, or beets. When the final product is highly purified to over 99.9% purity in accordance with USP standards, none of the protein from the original source remains. The product is bio-identical to vitamin C found in plants and animals. This is an important fact in the current issues relating to genetically modified organisms (GMOs) in corn, potatoes, and beets. Polymerase chain reaction (PCR) testing is currently used to verify and certify that most of the vitamin C being produced is GMO free. To learn more about testing for GMOs, visit: http://www.gmotesting.com/Testing-Options/Genetic-analysis.aspx.

pro-c-180-f pro-c vitamin c bioflavonoids



Bone and its connecting ligaments and tendons obtain strength from a long, chain-like protein molecule called collagen. Collagen is a structural protein that is the main component of connective tissue, and is the most abundant protein in mammals, making up about 25% to 35% of the whole-body protein content.

Vitamin C is vital to the body’s production of collagen. Absence of vitamin C causes scurvy, leading to spongy gums, loosened teeth, bruising, and bleeding into the mucous membranes. Several of these symptoms are caused by loss of collagen and connective tissue from blood vessels, which then become fragile and unable to respond to blood pressure and other stresses.

Studies have shown that vitamin C concentrations in the plasma and leukocytes rapidly decline during infections and stress. Supplementation of vitamin C has been found to improve components of the human immune system such as antimicrobial and natural killer cell activities, lymphocyte proliferation, chemotaxis, and delayed-type hypersensitivity.

Vitamin C contributes to maintaining the redox integrity of cells, and thereby protects them against reactive oxygen species generated during the respiratory burst and in the inflammatory response. It is therefore clear that vitamin C plays an important role in immune function and the modulation of host resistance to infectious agents, reducing the risk, severity, and duration of infectious diseases.

Vitamin C plays a role in protecting the brain and nervous system from detrimental effects of stress. Synthesis and maintenance of the chemical messengers (neurotransmitters) adrenaline (epinephrine) and noradrenaline (norepinephrine) depends on an adequate supply of vitamin C. These neurotransmitters are vital to brain functioning and affect people’s mood. They function as stress-signaling hormones and are produced in the adrenal glands, from which they derive their name. The adrenal glands and central nervous system maintain high levels of vitamin C by means of special cellular pumps, which absorb the vitamin when the body is deficient.

Vitamin C is also needed for synthesis of carnitine, a small molecule involved in transporting fat (lipids) to mitochondria, the “furnaces” of the body’s cells that burn nutrients to produce energy. The energy provided is used either to power the cells’ activities or to provide antioxidant electrons that prevent harmful oxidation.

Vitamin C is involved in breaking down cholesterol to form bile acids. This may have implications for people needing to lower their cholesterol levels. While the role of cholesterol in causing cardiovascular disease is generally overstated, the action of vitamin C on cholesterol levels suggests that higher levels may lower the risk of gallstones.

Vitamin C has been shown to lower lipoprotein a (LPa) levels in the body. High LPa levels correlate strongly with cardiovascular disease. Dr. Linus Pauling and others have suggested that the body uses plaques containing LPa to “patch” weak blood vessels that are caused by insufficient levels of vitamin C to build strong vessels with adequate collagen.

Vitamin C is widely known as an antioxidant, a substance that fights free radicals that can damage tissues and cause illness. As the principal water-soluble antioxidant in the diet, vitamin C is essential to health.

A shortage of vitamin C results in free radical damage to essential molecules in the body. The molecules affected include DNA (deoxyribonucleic acid) and RNA (ribonucleic acid), proteins, lipids (fats), and carbohydrates. Examples of sources of damaging free radicals and oxidation include mitochondrial by-products, chemical toxins from smoking, exposure to pesticides, as well as x-rays and other types of radiation.

The importance of vitamin C in preventing free radical damage, aging, and oxidation is frequently understated by those who are unaware of the volumes of research and clinical studies that have been conducted since the 1930s. An adequate supply of vitamin C enables the regeneration of vitamin E and other antioxidants in the body. The main water-soluble antioxidant generated within our cells is called glutathione, a small protein molecule (tripeptide of the amino acids glutamic acid, cysteine, and glycine) that plays a central role in protecting our cells from oxidation damage.

Because glutathione is typically present in ten times the concentration of vitamin C, it has often been considered to play a more important role. However, the functions of vitamin C and glutathione are linked with vitamin C being required for the antioxidant functioning of glutathione, even when glutathione is present in a significantly greater concentrations.

In nature vitamin C is often found in combination with plant substances called polyphenols and bioflavonoids. These plant substances are often powerful antioxidants and Nrf2 activators that stimulate the body’s endogenous production of protective enzymes. In fact, oligomeric proanthocyanidins (OPCs) from grape seeds and pine bark have been shown to cross link and strengthen collagen that requires vitamin C for synthesis. For these reasons, it makes sense to combine vitamin C with these plant substances.

I have formulated powerful products such as PRO-C™ and Ultimate Protector™ that contain vitamin C with plant substances such as grape seed extract, green tea extract, and fruit and vegetable extracts high in Nrf2 activators.

ultimate protector vitamin c

Ultimate Protector™ 


Single-digit, gram-level doses of vitamin C may prevent many diseases, but much higher doses are required for treatment of illness. The massive doses needed for therapy are often in the range of 50–100 grams (50,000–100,000 mg) of vitamin C per day. Most clinical studies have considered doses of a single gram. A dose 100 times larger has very different properties.

An optimal intake of vitamin C is the amount that prevents or cures disease while minimizing the potential risk. It is a ridiculous assumption to think that intakes sufficient to prevent acute scurvy are adequate to prevent or treat other diseases. Furthermore, there is plenty of evidence that the intake of vitamin C needed to prevent chronic illness is much greater than the RDA.

A person starting to take vitamin C supplements is starting from a level of relative deficiency. By taking repeated doses, the levels in the tissues and blood plasma increase and more can be tolerated. Human requirements for vitamin C appear to be more variable than previously realized.

The key point is that people need more vitamin C — and in many cases far more — than previously assumed. Using the criteria used to set the RDA, and removing the errors, leads to a suggestion that the intake for a healthy adult should be in the range of about 500 mg to 20 grams (20,000 mg), or even more. Some individuals would require low doses and would not tolerate higher intakes. Other individuals need higher levels, above 10 grams.

A person who wishes to estimate his or her own requirement needs to determine their bowel tolerance level. To do this, start with a low dose and repeat it each hour until bowel effects (gas, distension, and loose stools) are observed. This level of intake is your bowel tolerance level and the optimal intake is 50% to 90% of this maximum.

Keep in mind that a high carbohydrate intake can interfere with the bowel tolerance test and falsely indicate a lower limit. In addition, during times of illness your bowel tolerance level can be many times higher than when you are in a state of good health. Furthermore, the level that a person can tolerate increases with time, as dynamic flow is maintained.

People vary in their requirements and it is not possible to provide a definitive statement about intakes that applies to all. Furthermore, a person’s requirement will vary, increasing with even a slight illness. The minimum intake required to raise a typical adult’s blood plasma levels consistently is two to three grams (2,000–3,000 mg) per day, in divided doses of about 500–1,000 mg. For some, this will be too high and they may need to lower the dose slightly. For many, this intake will be far too low to provide resistance to infections and chronic disease.

Vitamin C is remarkably safe, which is not surprising considering it is essential to human life and is actively retained in the body. Vitamin C is a simple molecule, used by both animals and plants, often at high concentrations. Organisms have had hundreds of millions of years to evolve mechanisms for prevention of damage by vitamin C. But even allowing for such tolerance, the safety of vitamin C is outstanding. It is unusual in that it can be taken in massive doses, for long periods, without apparent harm.

Therapeutic levels of vitamin C required for dealing with serious illnesses are much higher than the levels described above. Under these conditions, Dr. William Klenner, one of the pioneers of vitamin C usage, recommended the amount of 350 mg per kilogram of body weight per day.

In most cases, Dr. Klenner recommended that the doses be divided into amounts taken hourly during waking hours. For example, a 50 kg (110 lb) person should take a total of 18,000 mg daily in hourly 1,000 mg doses for 18 hours. A 100 kg (220 lb) person should take 36,000 mg daily in hourly 2,000 mg doses for 18 hours. When dealing with conditions of illness these (and even higher) doses do not usually cause diarrhea. However, you can adjust these starting doses up or down according to your bowel tolerance level.


Vitamin C is considered to be a vitamin because in relatively small amounts (less than 60 mg) it prevents and cures scurvy. However, vitamin C is so important that virtually every plant and animal on this planet requires it to be healthy. In conditions of good health the body needs between three and twenty (3–20) grams of vitamin C daily to maintain good health and prevent a wide range of serious health problems. In many conditions of poor health and illness the body can require amounts of vitamin C as high as 100 grams (and in some cases more) in order to recover.

The best way to determine your personal need for vitamin C is to check your bowel tolerance level and supplement in divided daily doses with about 70% of this level. My personal recommendation is that most people should take the buffered forms of vitamin C that are combined with other antioxidants and plant polyphenols such as are in PRO-C™ and Ultimate Protector™. In cases where higher levels of vitamin C are called for (greater than 20 grams daily) I suggest adding buffered C powder and or ascorbic acid crystals to the PRO-C™ and Ultimate Protector™.

In my personal experience, vitamin C is an amazing nutrient especially in combination with other antioxidants. For this reason it is one of the foundational supplements in the HPDI Master Rejuvenation Program.



  1. The Vitamin C Cure for Heart Disease. Hilary Roberts and Steve Hickey, 2011.
  2. Vitamin C: The Real Story. Steve Hickey and Andrew Saul, 2009.
  3. Curing the Uncurable: Vitamin C, Infectious Diseases, and Toxins, 3rd Ed. Thomas E. Levy, 2009.
  4. Cancer and Vitamin C: A Discussion of the Nature, Causes, Prevention, and Treatment of Cancer With Special Reference to the Value of Vitamin C. Ewan Cameron and Linus Pauling, 1993.
  5. How to Live Longer and Feel Better.  Linus Pauling, 1986.
  6. Vitamin C, the Common Cold and the Flu. Linus Pauling, 1977.
  7. The Healing Factor: Vitamin C Against Disease.  Irwin Stone, 1972.
  8. Bowel tolerance as an indicator of vitamin C saturation is discussed by Dr. RF Cathcart at http://www.doctoryourself.com/titration.html and http://www.doctoryourself.com/cathcart_thirdface.html
  9. For more about Dr. Klenner’s life and work: http://www.doctoryourself.com/klennerbio.html
  10. The complete text of Irwin Stone’s book The Healing Factor is posted for free reading at http://vitamincfoundation.org/stone/
  11. The full text of Dr. Frederick R. Klenner’s Clinical Guide to the Use of Vitamin C is posted for free reading at: http://www.seanet.com/~alexs/ascorbate/198x/smith-lh-clinical_guide_1988.htm