Dr. Hank Liers, PhD pro-c™ pro-c super antioxidant formulaFred Liers PhD pro-c antioxidant vitamin c nrf2 formulaLooking for an advanced antioxidant formula? Already using or recommending vitamin C? Curious about cellular Nrf2 activation? Look no further than PRO-C™.

PRO-C™ is among the most effective antioxidant formulas available. It is an HPDI foundational supplement that works most effectively when used with multivitamins, essential fats, and superfoods. However, it is also an excellent standalone formula that can rapidly provide the body with extremely high protection from free radicals.

We ourselves have taken PRO-C daily for many years with excellent results. Our personal experience together with detailed feedback from health professionals and end-users affirms the effectiveness of PRO-C as a super-antioxidant–vitamin C-Nrf2 activator formula.

PRO-C provides 500 mg of buffered vitamin C per capsule (buffered with calcium, magnesium, and zinc) along with grape extract (seed, skin, pulp) and green tea extract (95% polyphenols). In addition, we include a special combination of the “network antioxidants” l-glutathione (reduced), n-acetyl-l-cysteine (NAC), r-lipoic acid, and selenium. Vitamin B2 and Vitamin B6 in coenzyme forms support the enzymatic effectiveness of the “network antioxidants”. The formula works so well because this combination of ingredients leverages the antioxidant power of vitamin C, grape extract, green tea extract, and the other nutrients to act synergistically in order to maximize effectiveness.


What you may not know is the history of the development PRO-C and the scientific knowledge on which Dr. Hank Liers based his formulation of it.

Dr. Hank formulated his first product in 1989. It was a potent antioxidant formula he called PYC-C™ (sounds like “pixie”). PYC-C consisted of a combination of buffered Vitamin C (including magnesium, calcium, and zinc ascorbates) and pycnogenols from pine bark.

Much of the scientific research data Dr. Hank collected during the development of PYC-C regarding oligomeric proanthocyanidins (OPC) he later incorporated into an article (currently published on this blog) titled “Review of Scientific Research on Oligomeric Proanthocyanidins (OPC)” (rev. 2017)

By 1997 Dr. Hank had gathered a great deal of new scientific information regarding green tea catechins and the nutrients termed “network antioxidants” by Dr. Lester Packer, director of Packer Lab at University of California, Berkeley. Beyond this information, Dr. Hank studied additional research regarding how various nutrients worked together synergistically. At that point, he was ready to formulate the new, improved PRO-C™ super antioxidant formula.

PRO-C combines the ingredients of PYC-C (now known as OPC-C™) and uses grape pulp, skin, and seed extract with green tea extract (with high polyphenols >95% and EpiGalloCatechinGalate (EGCG) >45%), n-acetyl-l-cysteine (NAC), reduced glutathione (GSH), R-lipoic acid, selenium, and coenzyme Vitamins B2 and B6.

PRO-C super antioxidant formula 180 cap 90 cap

HPDI launched PRO-C™ in late 1997. It rapidly became one of our best-selling products. Our customers raved about how effective it was for them if they felt like they were “coming down with something” (like a cold, flu, virus, infection, etc.). Greater skin elasticity greatly helped pregnant women avoid stretch marks and episiotomies. Today, we highly recommend its use together with our other Foundational Supplements to ensure optimal health and anti-aging effects.


PRO-C™ super antioxidant formula is extremely synergistic, especially in so far as it increases the body’s ability to quench free radicals in its aqueous (i.e., water-based) compartments. Because antioxidants may become free radicals themselves after they have done their job, the body has developed an elaborate system for recovery of oxidized antioxidants.


Dr. Lester Packer was the primary researcher investigating the synergistic character of antioxidants. He made this statement in his interview with Dr. Richard Passwater after publication of Packer’s The Antioxidant Miracle (1999):

[The major theme of] The Antioxidant Miracle is that antioxidants work in a coordinated manner. They interact with one another, and this interaction, which we like to call the antioxidant network, is very important to the overall antioxidant defense that we possess. The key members of the antioxidant network are vitamin E and vitamin C, but there are other participants in this network. These are thiol antioxidants, antioxidants that contain sulfur groups in the body. Glutathione perhaps is the best known of these, but there are other sulfur-containing antioxidants that also are very important.”

Dr. Packer continues:

“This whole antioxidant network works like an orchestra depending on individuals who have, of course, different complements of antioxidants depending upon their nutritional regimens and the individuality of their own body metabolisms. The idea behind having a network of antioxidants is that if one antioxidant happens to be deficient the others can compensate and still keep the antioxidant defense system strong.”

The following diagram shows some of the relationships in the antioxidant network and how they support each other.

Lester Packer antioxidant network diagram Figure 1 – Dr. Packer’s Antioxidant Network

We see, for example, reduced glutathione (GSH) has the ability to reduce oxidized Vitamin C back to its unoxidized state. Vitamin C reduces oxidized Vitamin E back to its unoxidized state, and both reduces glutathione and spares it for other important functions, including detoxification and immune enhancement.

Many polyphenols (e.g., oligomeric proanthocyanidins (OPCs), anthocyanidins and catechins) found in red grape and green tea extracts spare Vitamin C and glutathione in the body, as well as operate as powerful antioxidants, anti-inflammatories, and connective tissue strengtheners.

grapes grape extract antioxidant

Grapes provide antioxidant nutrients such as polyphenols, OPCs, anthocyans, and resveratrol.

R-Lipoic Acid (see abstracts below) operates as an antioxidant both in its oxidized and reduced states, reduces the oxidized forms of both Vitamin E and Vitamin C, and and has been shown to enhance glutathione levels. Because several of these substances are able to protect Vitamin E contained in cell membranes, this combination also has a significant beneficial effect on the fat soluble antioxidant status of the body!

The nutrients in PRO-C have been carefully selected and balanced to provide optimal effects, especially as related to free radical protection, detoxification, immune system enhancement, connective tissue strengthening, and reduction of inflammation. PRO-C therefore provides outstanding nutritional support in a wide variety of conditions of poor health, as well as acts to support and maintain a state of health and well-being.

It the last several years the research results on Nrf2 activators have become well known and products developed that take advantage of these nutrients. For details see our blog article Natural Phytochemical Nrf2 Activators for Chemoprevention. Researchers have been studying specifically how enzyme-activating substances such as OPCs and anthocyans activate a transcription factor known as Nrf2 that causes the body to endogenously produce higher levels of a wide variety of protective enzymes including superoxide dismutase (SOD), catalase, and glutathione peroxidase.

Although we did not know about Nrf2 activators in 1997 when we formulated PRO-C, we have subsequently learned that four of the ingredients in the formula have powerful Nrf2 activity. These include grape seed extract, green tea extract, NAC, and r-lipoic acid. With this knowledge, we now understand that PRO-C provides both powerful external antioxidants (with extremely high ORAC5.0 values) that support redox cycles within the body, but also provides ingredients that allow the body to endogenously produce powerful protective enzymes for even greater free-radical protection and health.


PRO-C contains buffered vitamin C (in the form of powdered calcium, magnesium, and zinc ascorbates), high-potency grape extract (from grape pulp, skins, and seeds), green tea extract (with>95% polyphenols and >45% EGCG), reduced glutathione, N-Acetyl-L-Cysteine (NAC), R-lipoic acid, coenzyme forms of vitamin B2 (R5P) and vitamin B6 (P5P), and selenium.

Below we will discuss each ingredient and show some of the research that confirms its effectiveness.


Vitamin C typically is called l-ascorbic acid or ascorbate and is an essential nutrient for humans and other animal species. The term “vitamin C” refers to a number of vitamins that have vitamin C activity in animals, including ascorbic acid and its salts (e.g., magnesium ascorbate, calcium ascorbate, sodium ascorbate, etc.), and some oxidized forms such as dehydroascorbate and semidehydroascorbate.

Vitamin C is known to perform many critical functions within the body involving detoxification, tissue building, immune enhancement, pain control, and controlling or killing pathogenic organisms. It is also known to be helpful for wound and bone healing, healthy skin and eyes, fighting infections, stress control, toxic exposure, and repairing damaged tissue of all types. For much more information on the many benefits of Vitamin C see our blog article Vitamin C – An Amazing Nutrient.

Below are two abstracts that show some of the beneficial effects of Vitamin C when used with other network antioxidants:

Exhaustive physical exercise causes oxidation of glutathione status in blood: prevention by antioxidant administration.
Sastre J, Asensi M, Gasco E, Pallardo FV, Ferrero JA, Furukawa T, Vina J
In: Am J Physiol (1992 Nov) 263(5 Pt 2):R992-5

We have studied the effect of exhaustive concentric physical exercise on glutathione redox status and the possible relationship between blood glutathione oxidation and blood lactate and pyruvate levels. Levels of oxidized glutathione (GSSG) in blood increase after exhaustive concentric physical exercise in trained humans. GSSG levels were 72% higher immediately after exercise than at rest. They returned to normal values 1 h after exercise. Blood reduced glutathione (GSH) levels did not change significantly after the exercise. We have found a linear relationship between GSSG-to-GSH and lactate-to-pyruvate ratios in human blood before, during, and after exhaustive exercise. In rats, physical exercise also caused an increase in blood GSSG levels that were 200% higher after physical exercise than at rest. GSH levels did not change significantly. Thus, both in rats and humans, exhaustive physical exercise causes a change in glutathione redox status in blood. We have also found that antioxidant administration, i.e., oral vitamin C, N-acetyl-L- cysteine, or glutathione, is effective in preventing oxidation of the blood glutathione pool after physical exercise in rats.

The effect of glutathione and vitamins A, C, and E on acute skin flap survival.

Hayden RE, Paniello RC, Yeung CS, Bello SL, Dawson SM
In: Laryngoscope (1987 Oct) 97(10):1176-9

Vitamins A, C, and E act as antioxidants and as free radical scavengers in biological systems. Glutathione is involved in several reactions in vitamin metabolism and also plays an important role in cell membrane protection against lipid peroxidation by free radicals. We sought to use these natural defense mechanisms against oxygen free radicals formed during reperfusion of ischemic skin flaps. An acute axial random skin flap model was utilized in the rat. Vitamins or glutathione were administered by oral gastric tube or intravenously in the perioperative period, and survival of the flap was measured at 1 week. Glutathione, beta-carotene, ascorbic acid and alpha-D- tocopherol showed mean flap survival of 84% to 89%, each of which was significantly improved over saline controls (67% p less than .0005). The mechanisms and biochemistry of these vitamins, and their interactions with other vitamins and with glutathione, are discussed, along with clinical implications of free radical scavenging and skin flap survival.


Grape extract (seeds, skin, pulp) contain highly bioavailable bioflavonoid complexes that in research studies have been shown to have powerful antioxidant capability. The Oligomeric Proanthocyanidins (OPCs) in grape seed extract are able to strengthen collagen fibers in aging or damaged connective tissue and can act as a preventative against connective tissue degradation.

Some research indicates that anthocyans, which are found in extracts of grape skin and stems (but not in grape seed extract), can reduce oxidized glutathione while at the same time become reduced themselves. In addition, extracts of grape skin and stems (but not those of grape seed extract) contain a material called trans-resveratrol that has been shown to have chemopreventive effects.

Below we have provided some of the abstracts that are included in our broad list of relevant abstracts for PRO-C.

Protective effects of grape seed proanthocyanidins and selected antioxidants against TPA-induced hepatic and brain lipid peroxidation and DNA fragmentation, and peritoneal macrophage activation in mice.
Bagchi D, Garg A, Krohn RL, Bagchi M, Bagchi DJ, Balmoori J, Stohs SJ
In: Gen Pharmacol (1998 May) 30(5):771-6

1. The comparative protective abilities of a grape seed proanthocyanidin extract (GSPE) (25-100 mg/kg), vitamin C (100 mg/kg), vitamin E succinate (VES) (100 mg/kg) and beta-carotene (50 mg/kg) on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced lipid peroxidation and DNA fragmentation in the hepatic and brain tissues, as well as production of reactive oxygen species by peritoneal macrophages, were assessed. 2. Treatment of mice with GSPE (100 mg/kg), vitamin C, VES and beta-carotene decreased TPA-induced production of reactive oxygen species, as evidenced by decreases in the chemiluminescence response in peritoneal macrophages by approximately 70%, 18%, 47% and 16%, respectively, and cytochrome c reduction by approximately 65%, 15%, 37% and 19%, respectively, compared with controls. 3. GSPE, vitamin C, VES and beta-carotene decreased TPA-induced DNA fragmentation by approximately 47%, 10%, 30% and 11%, respectively, in the hepatic tissues, and 50%, 14%, 31% and 11%, respectively, in the brain tissues, at the doses that were used. Similar results were observed with respect to lipid peroxidation in hepatic mitochondria and microsomes and in brain homogenates. 4. GSPE exhibited a dose-dependent inhibition of TPA- induced lipid peroxidation and DNA fragmentation in liver and brain, as well as a dose-dependent inhibition of TPA-induced reactive oxygen species production in peritoneal macrophages. 5. GSPE and other antioxidants provided significant protection against TPA-induced oxidative damage, with GSPE providing better protection than did other antioxidants at the doses that were employed.

Clinical and capillaroscopic evaluation of chronic uncomplicated venous insufficiency with procyanidins extracted from vitis vinifera
Costantini A, De Bernardi T, Gotti A
In: Minerva Cardioangiol (1999 Jan-Feb) 47(1-2):39-46

BACKGROUND: The pharmacological treatment of non-complicated chronic venous insufficiency is a current and well-debated topic. The introduction of new products with action on the venous system, improved knowledge on the physiopathology of venous insufficiency and the possibility provided by new analytical instruments, have given new impulse to the consolidation of the clinical value of phlebotonics in this indication. METHODS: In light of this, 24 patients with non-complicated chronic venous insufficiency were treated with oral administration of Oligomeric Proanthocyanidins (Pycnogenols-OPC) 100 mg/day. To evaluate the therapeutic efficacy of the treatment, an instrumental evaluation by optical probe capillaroscope was employed in addition to the traditional subjective clinical parameters: swelling, itching, heaviness and pain. The videocapillaroscope examination was performed at the lower third of the leg and the first toe. Edema in the capillaroscopic field, the number of observable capillaries and the capillary dilatation were the parameter chosen to evaluate the efficacy of treatment. All patients completed the study with no reports of adverse events during the period of observation. RESULTS: The results obtained show a positive clinical response (improved or absent symptoms) in over 80% of patients, with significant improvement of symptoms already evident after the first 10 days of treatment. The mechanism of action of the OPCs explains the rapid reduction of the swelling of the lower limbs and correlated with this are the other evaluable symptoms: heaviness and itching. Particularly striking results were observed for itching and pain which completely disappeared during the course of therapy in 80% and 53% of the patients respectively. Noteworthy is the good correlation between the clinical and instrumental data, with improvement in a total of 70% of patients. CONCLUSIONS: The results obtained in the course of this clinical experience, with evident improvement already during the first weeks of treatment, the absence of adverse events added to the benefit of a once-a-day administration, justify the use of OPC in the treatment of non-complicated chronic venous insufficiency.

Polymeric procyanidin fraction from defatted grape seeds protects HepG2 cells against oxidative stress by inducing phase II enzymes via Nrf2 activation.
Younghwa Kim, Youngmin Choi, Hyeonmi Ham, Heon-Sang Jeong, Junsoo Lee
Kim, Y., Choi, Y., Ham, H. et al. Food Sci Biotechnol (2013) 22: 485. https://doi.org/10.1007/s10068-013-0105-x

Nuclear factor erythroid 2-related factor 2 (Nrf2) is an important transcription factor that regulates antioxidant response element (ARE)-driven phase II detoxification enzymes. In this study, induction of phase II enzymes via Nrf2/ARE activation in the cytoprotective effect of crude polyphenol extract (CPE), oligomeric procyanidin fraction (OPF), and polymeric procyanidin fraction (PPF) from defatted grape seeds in HepG2 cells was evaluated. Among these treatments, the treatment with PPF significantly increased Nrf2 protein expression in the nuclear fraction. Treating the samples increased heme oxygenase-1 (HO-1) and NAD(P)H:quinone oxidoreductase 1 (NQO1) protein expression in a dose-dependent manner, and PPF significantly increased the levels of phase II enzymes. Cellular generation of reactive oxygen species (ROS) were effectively reduced by PPF. These results suggest that pretreatment with PPF shows a cytoprotective effect by inhibiting ROS production and inducing HO-1 and NQO1 expression via Nrf2 activation in HepG2 cells.


Green tea extract is obtained from the unfermented leaves of Camellia sinensis for which numerous biological activities have been reported including: antimutagenic, antibacterial, hypocholesterolemic, antioxidant, and protective against tumorigenesis. Below we have selected a few of the many abstracts we have on file showing the benefit of green tea extract.

Green tea antioxidant polyphenols catechins

Green tea leaves are high in antioxidant polyphenols and catechins.

Enhancement of antioxidant and phase II enzymes by oral feeding of green tea polyphenols in drinking water to SKH-1 hairless mice: possible role in cancer chemoprevention.
Khan SG, Katiyar SK, Agarwal R, Mukhtar H
In: Cancer Res (1992 Jul 15) 52(14):4050-2

Following the oral feeding of a polyphenolic fraction isolated from green tea (GTP) in drinking water, an increase in the activities of antioxidant and phase II enzymes in skin, small bowel, liver, and lung of female SKH-1 hairless mice was observed. GTP feeding (0.2%, w/v) to mice for 30 days significantly increased the activities of glutathione peroxidase, catalase, and quinone reductase in small bowel, liver, and lungs, and glutathione S-transferase in small bowel and liver. GTP feeding to mice also resulted in considerable enhancement of glutathione reductase activity in liver. In general, the increase in antioxidant and phase II enzyme activities was more pronounced in lung and small bowel as compared to liver and skin. The significance of these results can be implicated in relation to the cancer chemopreventive effects of GTP against the induction of tumors in various target organs.

In: Anticancer Drugs (1996 Jun) 7(4):461-8
Institutional address: Department of Pharmacology and Toxicology College of Pharmacy University of Arizona Tucson 85721 USA.

Green tea is an aqueous infusion of dried unfermented leaves of Camellia sinensis (family Theaceae) from which numerous biological activities have been reported including antimutagenic, antibacterial, hypocholesterolemic, antioxidant, antitumor and cancer preventive activities. From the aqueous-alcoholic extract of green tea leaves, six compounds (+)-gallocatechin (GC), (-)-epicatechin (EC), (-)- epigallocatechin (EGC), (-)-epicatechin gallate (ECG), (-)- epigallocatechin gallate (EGCG) and caffeine, were isolated and purified. Together with (+)-catechin, these compounds were tested against each of four human tumor cells lines (MCF-7 breast carcinoma, HT-29 colon carcinoma, A-427 lung carcinoma and UACC-375 melanoma). The three most potent green tea components against all four tumor cell lines were EGCG, GC and EGC. EGCG was the most potent of the seven green tea components against three out of the four cell lines (i.e. MCF-7 breast cancer, HT-29 colon cancer and UACC-375 melanoma). On the basis of these extensive in vitro studies, it would be of considerable interest to evaluate all three of these components in comparative preclinical in vivo animal tumor model systems before final decisions are made concerning which of these potential chemopreventive drugs should be taken into broad clinical trials.


Glutathione and NAC (a major precursor of glutathione) both provide important protection against toxins and free radicals, and can strengthen the immune system. Glutathione is considered to be one of the most important protective substances in the human body with almost 60% of liver detoxification accounted for by this key substance. In addition, glutathione is one of the most potent anti-viral substances known.

Some research has indicated that glutathione may not be able to enter easily into certain types of cells, but NAC is able to enter these cells and be converted into glutathione once inside the cell. Thus, the combination of glutathione and NAC appear to be more potent than either alone.

Below we provide some of the key abstracts we have on file regarding NAC and glutathione.

GSH rescue by N-acetylcysteine.
Ruffmann R Wendel A
In: Klin Wochenschr (1991 Nov 15) 69(18):857-62

Reduced glutathione (GSH) is the main intracellular low molecular weight thiol. GSH acts as a nucleophilic scavenger and as an enzyme-catalyzed antioxidant in the event of electrophilic/oxidative tissue injury. Therefore, GSH has a major role as a protector of biological structures and functions. GSH depletion has been recognized as a hazardous condition during paracetamol intoxication. Conversely, GSH rescue, meaning recovery of the protective potential of GSH by early administration of N-acetylcysteine (NAC), has been found to be life-saving. Lack of GSH and electrophilic/oxidative injury have been identified among the causes of the adult respiratory distress syndrome (ARDS), idiopathic pulmonary fibrosis (IPF), and the acquired immunodeficiency syndrome (AIDS). Experimental and early clinical data (in ARDS) point to the role of NAC in the treatment of these conditions. Recently, orally given NAC has been shown to enhance the levels of GSH in the liver, in plasma, and notably in the bronchoalveolar lavage fluid. Rescue of GSH through NAC needs to be appreciated as an independent treatment modality for an array of different disease, all of which have one feature in common: pathogenetically relevant loss of GSH.

Cysteine and glutathione concentrations in plasma and bronchoalveolar lavage fluid after treatment with N-acetylcysteine.
Bridgeman MM Marsden M MacNee W Flenley DC Ryle AP
In: Thorax (1991 Jan) 46(1):39-42

N-acetylcysteine (600 mg/day) was given to patients by mouth for five days before bronchoscopy and bronchoalveolar lavage to determine whether N-acetylcysteine could increase the concentrations of the antioxidant reduced glutathione in plasma and bronchoalveolar lavage fluid. Bronchoalveolar lavage was performed 1-3 hours (group 2, n = 9) and 16-20 hours (group 3, n = 10) after the last dose of N-acetylcysteine and the values were compared with those in a control group receiving no N-acetylcysteine (group 1, n = 8). N-Acetylcysteine was not detected in plasma or lavage fluid. Plasma concentrations of cysteine, the main metabolite of N-acetylcysteine and a precursor of reduced glutathione, were greater in the groups receiving treatment (groups 2 and 3) than in group 1. Cysteine concentrations in lavage fluid were similar in the three groups. Concentrations of reduced glutathione were greater in both plasma and lavage fluid in group 2 than in group 1. These data suggest that N-acetylcysteine given by mouth is rapidly deacetylated to cysteine, with resulting increases in the concentrations of cysteine in plasma and of reduced glutathione in plasma and the airways, which thus temporarily increase the antioxidant capacity of the lung.


R-Lipoic Acid is normally made at low levels in the human body, where it functions primarily as an important metabolic nutrient in the conversion of pyruvic acid into acetyl coenzyme A. As such, it plays a crucial role in the metabolism of both fats and carbohydrates into energy. In addition, r-lipoic acid functions as an extremely powerful antioxidant capable of trapping many different types of free radicals in the body.

Because it is both water and fat soluble, lipoic acid is able to operate in a broader range of body tissues than most other antioxidants. Its small size allows lipoic acid to enter areas of the body not easily accessible to many other substances; this allows lipoic acid, for example, to enter the cell nucleus and prevent free-radical damage to DNA.

Because it is such a powerful antioxidant and can easily function as such in both a reduced and oxidized state, lipoic acid is able to protect other important antioxidants such as glutathione, Vitamin E, and Vitamin C. R-lipoic acid is also able to chelate heavy metals such as lead, cadmium, mercury, free iron, and free copper out of the body.

Below we provide relevant scientific abstracts from our database regarding R-Lipoic acid.

Alpha-Lipoic acid as a biological antioxidant.
Packer L Witt EH Tritschler HJ
In: Free Radic Biol Med (1995 Aug) 19(2):227-50

alpha-Lipoic acid, which plays an essential role in mitochondrial dehydrogenase reactions, has recently gained considerable attention as an antioxidant. Lipoate, or its reduced form, dihydrolipoate, reacts with reactive oxygen species such as superoxide radicals, hydroxyl radicals, hypochlorous acid, peroxyl radicals, and singlet oxygen. It also protects membranes by interacting with vitamin C and glutathione, which may in turn recycle vitamin E. In addition to its antioxidant activities, dihydrolipoate may exert prooxidant actions through reduction of iron. alpha-Lipoic acid administration has been shown to be beneficial in a number of oxidative stress models such as ischemia-reperfusion injury, diabetes (both alpha-lipoic acid and dihydrolipoic acid exhibit hydrophobic binding to proteins such as albumin, which can prevent glycation reactions), cataract formation, HIV activation, neurodegeneration, and radiation injury. Furthermore, lipoate can function as a redox regulator of proteins such as myoglobin, prolactin, thioredoxin and NF-kappa B transcription factor. We review the properties of lipoate in terms of (1) reactions with reactive oxygen species; (2) interactions with other antioxidants; (3) beneficial effects in oxidative stress models or clinical conditions.

Regeneration of glutathione by α-lipoic acid via Nrf2/ARE signaling pathway alleviates cadmium-induced HepG2 cell toxicity.
Zhang J, Zhou X, Wu W, Wang J, Xie H, Wu Z.
In: Environ Toxicol Pharmacol. 2017 Apr;51:30-37. doi: 10.1016/j.etap.2017.02.022. Epub 2017 Feb 27.

Alpha-lipoic acid (α-LA) is an important antioxidant that is capable of regenerating other antioxidants, such as glutathione (GSH). However, the underlying molecular mechanism by which α-LA regenerates GSH remains poorly understood. The current study aimed to investigate whether α-LA regenerates GSH by activation of Nrf2 to alleviate cadmium-induced cytotoxicity in HepG2 cells. In the present study, we found that cadmium induced cell death by depletion of GSH through inactivation of Nrf2. Addition of α-LA to cadmium-treated cells reactivated Nrf2 and regenerated GSH through elevating the Nrf2-downstream genes γ-glutamate-cysteine ligase (γ-GCL) and GR, both of which are key enzymes for GSH synthesis. However, blocking Nrf2 with brusatol in the cells co-treated with α-LA and cadmium reduced the mRNA and the protein levels of γ-GCL and GR, thus suppressed GSH regeneration by α-LA. Our results indicated that α-LA activated Nrf2 signaling pathway, which upregulated the transcription of the enzymes for GSH synthesis and therefore GSH contents to alleviate cadmium-induced cytotoxicity in HepG2 cells.


Selenium has been shown by clinical research to be a key mineral in the body’s defenses against free radicals and has been shown to be a major factor in reducing the symptoms of HIV infections and in the prevention of tumors. Selenium is used in conjunction with glutathione to form the powerful enzyme glutathione peroxidase that is responsible for detoxification of peroxides formed during the process of aerobic metabolism in humans and other animals.

Serum selenium concentrations in rheumatoid arthritis.
In: Ann Rheum Dis (1991 Jun) 50(6):376-8

O’Dell JR, Lemley-Gillespie S, Palmer WR, Weaver AL, Moore GF, Klassen LW

Selenium is a trace element and an essential part of the enzyme glutathione peroxidase, which protects cells from oxidative damage. Selenium has been shown to have antiproliferative, anti-inflammatory, antiviral, and immune altering effects. Serum selenium concentrations in 101 patients with seropositive rheumatoid arthritis were found to be significantly lower than those in 29 normal, healthy controls (mean (SD) 148 (42) v 160 (25) micrograms/l) and also lower than those in eight patients with fibrositis (148 (42) v 166 (25) micrograms/l). It is speculated that serum selenium concentrations may modulate the effect of viral or other infections in subjects with the appropriate genetic background and in this way enhance the development or progression of rheumatoid arthritis.

Studies on selenium in top athletes.
Dragan I, Ploesteanu E, Cristea E, Mohora M, Dinu V, Troescu VS
In: Physiologie (1988 Oct-Dec) 25(4):187-90

The authors performed a controlled trial in 18 top athletes (9 weight lifters and 9 rowers, girls) in order to make evident some chronic and acute effects (antioxidant) of selenium. Nonprotein–SH (essential glutathione), lipid peroxides (MDA-malondialdehyde), glucose-6-phosphate dehydrogenases (G-6-PDH) and fructose-1,6- diphosphate aldolase in serum, have been recorded initially on basal conditions, after 3 weeks of treatment (100 micrograms/day selenium or placebo) and again after 3 weeks of treatment, also on basal conditions, when crossing over the groups (between a free interval of 10 days). In another trial we registered these parameters on basal conditions and after two hours of hard training accompanied by a per oral administration of 150 micrograms selenium (respectively placebo). The results show significant changes under selenium treatment of the peroxides, G-6-PDH and light changes, not significant of the nonprotein–SH, changes which could suggest an antioxidant effect of this element.


Vitamin B2 as coenzyme riboflavin-5-phosphate is a key vitamin that supports the regeneration of glutathione (via glutathione reductase). Vitamin B6 as coenzyme pyridoxal-5-phosphate is a key vitamin that supports the ability of glutathione to combine with toxic substances (via glutathione transferase) in the process of eliminating them from the body. They are especially effective in their coenzyme forms which allows them to be directly utilized by the body starting in the intestinal tract.


Magnesium, zinc, and calcium synergistically work with (and enhance the effects of) the other ingredients in PRO-C. Minerals are especially needed as active components of enzymes that drive metabolic activity. For example, magnesium is required in the functioning of more than 325 types of enzymes.


HIGHLY EFFECTIVE VITAMIN C FORMULA PLUS ANTIOXIDANTS. A complete vitamin C formula, a powerful antioxidant Formula, and Nrf2 activator combined in a single advanced supplement!

POWERFUL, SYNERGISTIC FREE-RADICAL QUENCHING FORMULA. PRO-C™ components work together to quench free radicals in your body. Vitamin C enables grape seed extract to function more effectively, and conversely grape seed extract potentiates vitamin C. Green tea extract boosts ORAC (Oxygen Radical Absorbance Capacity) value.

PROVIDES SIGNIFICANT AMOUNTS OF POWERFUL NRF2 ACTIVATORS (from Grape Extract, Green Tea Extract, NAC, and R-Lipoic Acid) that stimulate the production of the body’s own protective antioxidants including superoxide dismutase, catalase, glutathione peroxidase, and heme oxygenase.

SUPERIOR, BUFFERED (NON-ACIDIC) FORM OF VITAMIN C. Mineral Ascorbates never acidify your body, keeping you pH balanced. Staying alkaline is an important element in maintaining a healthy body.

RAPID ASSIMILATION. Capsule form ensures rapid uptake and assimilation in the body. You may also empty capsule contents into water, food, or directly Into mouth, if desired. Good, mildly tart taste!


One (1) vegetarian capsule of PRO-C provides the following percentages of the Daily Value:

Vitamin C (from mineral ascorbates) 500 mg 833%
BioVin® Grape Extract 30 mg *
Green Tea Extract 30 mg *
Calcium (from calcium ascorbate) 23 mg 2.3%
Magnesium (from magnesium ascorbate) 23 mg 5.7%
L-Glutathione (reduced) 20 mg *
N-Acetyl-L-Cysteine (NAC) 15 mg *
R-Lipoic Acid 5 mg *
Zinc (from zinc ascorbate) 2 mg 13%
Vitamin B2 (from riboflavin-5′-phosphate) 1 mg 118%
Vitamin B6 (from pyridoxal-5′-phosphate) 1 mg 50%
Selenium (from l-selenomethionine) 10 mcg *

* No established Daily Value

DIRECTIONS: As a dietary supplement take 1–3 capsules or more daily in divided doses (i.e., spread out over the day), or as recommended by a health care professional. It initially may be useful to take up to 6 capsules per day in divided doses for one week. The contents of the capsule may be emptied into juice or food, as needed.

INGREDIENTS: PRO-C™ SUPER ANTIOXIDANT FORMULA contains only the highest-quality USP grade magnesium ascorbate, USP grade calcium ascorbate, BioVin® grape extract (greater than 75% polyphenols, 55% OPC, greater than 3.5% anthocyanidins from grape pulp, skins, and seeds, and a small amount of trans resveratrol), green tea extract (95% min. polyphenols and 45% min. EGCG), l-glutathione (reduced), USP grade n-acetyl-l-cysteine, USP grade zinc ascorbate, r-(+)-lipoic acid, riboflavin-5′-phosphate, pyridoxal-5′-phosphate, l-selenomethionine, the smallest amounts of microcrystalline cellulose and silica in a vegetarian capsule.

PRO-C™ does not contain wheat, rye, oats, corn antigen, barley, gluten, soy, egg, dairy, yeast, sugar, sulfates, phosphates (other than coenzyme forms), fats, chlorides, GMOs, wax, preservatives, colorings, or artificial flavorings.

Click here to order PRO-C™.



The Antioxidant Miracle. Lester Packer, PhD, and Carol Coleman. New York: John Wiley and Sons, 1999.

How to Live Longer and Feel Better. Dr. Linus Pauling. Corvallis, OR: Oregon State University Press, 2006.


Review of Scientific Research on Oligomeric Proanthocyanidins (OPC)” (rev. 2017) by Hank Liers, PhD

“Vitamin C – An Amazing Nutrient” by Hank Liers, PhD

PRO-C™ and Ultimate Protector™ – Comparison by Hank Liers, PhD

“Antioxidant Cocktail Update: Part 1: The Take Home Message is to Use Antioxidant Supplements”
(An interview of Dr. Lester Packer by Richard A. Passwater, PhD, Whole Foods Magazine 1999)


PRO-C™ / Vitamin C Abstracts

Catechin Abstracts

N-Acetyl-L-Cysteine (NAC) Abstracts

Lipoic Acid Abstracts


(Therapeutic Nutrition Based Upon Biochemical Individuality)


PRO-C™Super Antioxidant Formula

Ultimate Protector™Nrf2 Activator Formula


HPDI Vitamin C Products



Fred Liers PhD intestinal rejuvenation formula IRFAmong the most essential aspects of detoxification are the sequestering of toxins and waste from the gastrointestinal tract and its proper elimination. HPDI’s Intestinal Rejuvenation Formula meets the need for an effective intestinal sweep to cleanse the entire GI tract for improved gut health and function.

Intestinal Rejuvenation Formula (or “IRF”) is our unique product that 1) latches onto toxins, old waste, and deposits in the digestive tract, 2) binds, pulls, and absorbs these materials, 3) sweeps them from the entire intestinal tract, while 4) naturally and gently facilitating elimination.

That’s just the start! You have to experience this formula yourself to appreciate its benefits most.

Intestinal Rejuvenation Formula works by coating and adhering to the lining of the intestines. This unique action allows it to absorb fecal plaques and other debris, soften unhealthy deposits, and sweep them away for elimination in the stool. The IRF formula thereby neutralizes and removes hundreds of toxins, including heavy metals like mercury and lead. It draws out many times its weight in material encrusted or trapped in the intestinal lining. It also provides nutrients not only known to nourish the GI tract, but also that promote normal elimination functions.

The easiest way to start using Intestinal Rejuvenation Formula is to put one teaspoon in eight ounces of water. Stir or shake, then drink immediately. You can then add some additional water to the container, stir and drink. You can start at 1/2 teaspoon (or less) if one teaspoon seems like too much. You can gradually work you way up to one tablespoon in 16 ounces of water or juice.

Note: It is important to consume the formula immediately after mixing with water to avoid the formula thickening which makes it difficult to drink. It is also important to consume sufficient water so it can swell and more easily pass through the digestive tract.

Intestinal Rejuvenation Formula

Intestinal Rejuvenation Formula is formulated to cleanse, detoxify, purify, and heal. You and your clients will love IRF!


Intestinal Rejuvenation Formula relieves symptoms of constipation, including gas, bloating, cramps, indigestion, and nausea caused by excessive waste in the bowel. It also soothes the intestinal lining and colon wall, and promotes a well-functioning colon. This means it can contribute to greater health not only through removal of toxins and intestinal blockages, but also by allowing greater absorption of nutrients from food (i.e., after the intestines are cleansed). It also can contribute to achieving normal weight by promoting elimination of old fecal matter (e.g., post-putrefactive deposits), and by helping to establish and maintain normal bowel function.

Intestinal Rejuvenation Formula acts as a wonderful soothing agent for the mucous membrane linings of the entire intestinal tract, especially the colon. This makes it an important formula for individuals experiencing irritable bowel syndrome, spastic colon, colitis, Crohn’s disease, diverticulitis, or any digestive tract condition causing hot, burning, irritated, or bleeding bowels and/or diarrhea. This unique healing formula is also an excellent remedy for food poisoning, because it can absorb harmful bacteria and toxins.

Intestinal Rejuvenation Formula also can be applied externally as a poultice to insect bites and stings (e.g., bee, ant, scorpion), snake bites, etc. The drawing power of the formula acts to pull toxins directly from wounds. Poultices are highly effective for pulling venoms, and work especially well when combined with echinacea tincture (used orally and topically) and homeopathic remedies (e.g., apis mellifera, ledum palustre, arnica montana). This application makes the formula truly unique. See directions (below) for external applications.


The ingredients in Intestinal Rejuvenation Formula make it one of the most effective products for complete cleansing of the gastrointestinal tract available today. IRF includes not only includes ingredients for binding and removing toxins and waste, but also for healing the entire GI tract.

INGREDIENTS: One teaspoon (3.23 gram) provides the following nutrients:

Psyllium Husk Powder (organic) – 1,000 mg
Apple Pectin – 400 mg
Bentonite Clay (wildcrafted) – 400 mg
Cold-Milled Flax Seed Powder (organic) – 400 mg
Marshmallow Root Powder (organic) – 200 mg
Slippery Elm Bark Powder (organic) – 200 mg
Activated Willow Charcoal (wildcrafted) – 100 mg
Spirulina Pacifica – 100 mg
Inulin / Fructooligosaccharides (from Chicory Root) – 100 mg
Ginger Root Powder (organic) – 100 mg
Natural Lemon Flavor – 100 mg
Vitamin C (from magnesium ascorbate) – 60 mg
Malic Acid – 50 mg
Grape Extract (pulp, skin, & seeds) – 40 mg
Licorice Root Powder (organic) – 40 mg
Stevia Leaf Extract (97% Rebaudioside A) – 13 mg
Magnesium (from magnesium ascorbate) – 4.5 mg
Chlorella Growth Factor (CGF) – 4 mg

Intestinal Rejuvenation Formula

The nutrients contained in Intestinal Rejuvenation Formula are all known to provide unique therapeutic benefits and healing properties. Consequently, the formula is carefully designed so the ingredients work together synergistically to leverage and maximize the capacities of each one. This results in a formula that is superior in action and that can far more effectively support health and healing in the intestinal tract than single ingredients or shotgun approaches (that often result in reduced effectiveness through the use of fillers, imbalanced formulation, or less than the highest quality ingredients).

Intestinal Rejuvenation Formula is a superior formulation representing a higher level of design expertise. This unique formula can offer significant benefits and results for individuals who wish to improve, regenerate, rejuvenate, heal, and sustain excellent gastrointestinal health.


Psyllium seed husks are soluble in water, expanding and becoming mucilaginous when moistened. Psyllium seed husks are indigestible in human beings and are used as a source of dietary fiber. They are used to relieve constipation, irritable bowel syndrome, diverticular disease, and diarrhea. They are also used as a regular dietary supplement to improve and maintain regular gastrointestinal (GI) transit. The inert bulk of the husks helps to provide a constant volume of solid material regardless of other aspects of the diet or any disease condition of the gut. Recent research also shows psyllium seed husks to be promising in lowering cholesterol and controlling diabetes.


As a dietary fiber, apple pectin is helpful in maintaining good digestive health. Pectin forms a colloidal solution in water and gels when cool. An indigestible, soluble fiber, apple pectin is a general intestinal regulator used in many healing preparations, especially as an anti-diarrheal agent. Researchers at the University of California, Davis (UCD), found that apple pectin acts as an antioxidant against the damaging portion of cholesterol in the blood stream.

It has been established that a diet rich in apple pectin may help protect against certain diseases. Research in Japan shows that apple pectin can act as a chemopreventive agent. Apple pectin helps maintain intestinal balance by cleansing the intestinal tract with its soluble and insoluble fibers. Apple pectin tends to increase acidity in the large intestines and is advocated for those suffering from ulcer or colitis and for regulating blood pressure. Pectin is also effective in causing regressions in and preventing gallstones. There is also evidence that the regular use of apple pectin may lessen the severity of diabetes.

Apple pectin is known to draw radiation from the body. Russian doctors have found apple pectin to be among the most effective means for protecting against radiation when consuming contaminated foods is unavoidable. Pectin, along with vitamins and minerals, eliminates radionuclides ingested from foods. This is especially relevant given recent meltdowns and radiation releases from the nuclear complex in Fukushima, Japan. Radiation from this catastrophe has contaminated (and continues contaminating) food crops across the entire northern hemisphere (and beyond), especially crops grown in North America.


Bentonite clay has a large and varied mineral content, including over 50 minerals. Seen under a high powered microscope, bentonite is composed of extremely minute rectangular particles. The wide surfaces are negatively charged and the edges are positively charged. Therefore, its adsorptive power is many thousand times more negative than positive. It has a negative electrical attraction for positively charged particles. In the human body, various toxic poisons are positively charged. The very minuteness of the particles give it a large surface area (about 1,000 square meters per gram) relative to its volume, thereby enabling it to pick up many times its own weight (as high as 40 times) in positively charged particles.

When bentonite clay absorbs water and swells, it stretches open like a highly porous sponge. Toxins (including pathogenic viruses, herbicides, and pesticides) are drawn into these spaces and bound through electrical attraction. The bentonite is eventually eliminated from the body with the toxins bound to its multiple surfaces. Diarrhea can be remedied through the use of bentonite clay because of its capacity to bind stools. Bentonite clay can act immediately to bind irritants in the gastrointestinal tract.

COLD-MILLED FLAX SEEDS (organically grown)

Flax Seeds (Linum usitatissimum L.) contain essential fatty acids (an excellent vegetarian source of omega-3 alpha-linolenic acid), protein, soluble fiber, insoluble fiber, antioxidant lignans, minerals, and vitamins. Lignans are a phytoestrogens considered to be antioxidants. Flax seeds contain among the highest levels of lignans among all plant foods.

The unique properties of Heartland’s RCM™ Flax (Real Cold Milled) organic flaxseed provides enormous advantages over whole flax seeds, ground flax powders, and other milled flax seed products. In particular, cold-milled flax seeds offer readily assimilable omega-3 and omega-6 fatty acids because of special no-heat processing that protects these delicate oils and makes them available for uptake into the body.

RCM™ Flax cold-milled flaxseed is processed using a unique, proprietary method that preserves the delicate oils and allows for optimal uptake of the oils and other nutrients (e.g., soluble fiber) into the body. That is, flax seeds must be milled into a flour or meal to obtain maximum benefits from its oils and dietary fiber. However, typical methods of grinding or pounding flaxseeds separate the oil from the seeds (and heat the oils), thereby causing the oils to oxidize and become rancid. In contrast, cold milling is a unique process that does not involve heating delicate oils and keeps them protected within finely milled pieces of seed. Thus, cold-milled flax seed is not significantly oxidized and remains fresh for an extended period of time. Conversely, when flax seeds are harshly ground or crushed, the oils do not remain fresh because there is no inherent protection from oxidation. Cold milling allows the seed to retain and protect its oils because the process does not release the oils from the seeds.

RCM™ Flax offers a non-refrigerated shelf life of greater than 24 months. A study conducted at North Dakota State University confirms that peroxide levels of RCM™ Flax remain exceptionally low for an extended periods. While this flaxseed retains its freshness for an extended period, when refrigerated (or consumed within several months), it provides amazingly high levels of freshness.

The organic cold-milled flax seeds in Intestinal Rejuvenation Formula contain oil amounts varying between 38–45%, with the oil offering a high percentage (47–53%) of the omega-3 alpha-linolenic acid (ALA) and 15–18% omega-6 linoleic acid. Alpha-linolenic acid (ALA) is an essential fatty acid acting in the human body as a substratum for the transformation into EPA and DHA through the action of desaturation and elongation enzymes. The seeds also contain some omega-6 essential fatty acids and exhibit a favorable omega-3 to omega-6 ratio of 3:1. Modern diets contain too few omega-3 fatty acids.

Cold-milled flax seeds possess 15–30% protein (typically 20%) and the amino acids of flax protein have no limiting factors in the adult diet (i.e., they are a complete protein source having all of the essential amino acids in an appropriate balance). Flax seeds are also a source of magnesium, calcium, potassium, phosphorus, zinc, and copper. They also have demonstrated antioxidant activity. The most important antioxidants they provide are phytoestrogens known as lignans. Because cold milling flax seeds significantly reduces oxidation, this exceptional flax seed has great potential within the food industry when compared to other alpha-linolenic acid sources, such as typical ground flaxseed powders, which can exhibit rapid decomposition due to a lack of antioxidant protection from oxidation.

The human body easily digests flax seeds. The seed’s outer layer is rich in mucilloid soluble fiber (flax seed possesses 10-15% soluble fiber) and absorbs at least 4 times its weight in water. When mixed with water or stomach juices, the seeds form a gel that creates a physical barrier between the carbohydrates and the digestive enzymes that break them down. The carbohydrates thereby are digested and converted into glucose (blood sugar) at a slow, uniform rate. There is no insulin surge or spike needed to lower the blood sugar level. The water-retaining capacity of the gel also maintains bodily hydration (i.e., helping level out water intake) and electrolyte balance.


Considered the king of mucilaginous (gel-like) slippery plants, marshmallow offers a unique composition of about 37% starch, 11% mucilage, and 11% pectin (including flavonoids and phenolic acids). When it reaches the colon, marshmallow gel will soften hardened fecal plaques and help to remove them from colon walls. It also acts as a soothing coating and internal moisturizer for the entire digestive tract. Like chia seeds, it neutralizes irritants often found in the intestinal system, and thereby greatly relieves irritation to the mucous membrane lining of the digestive tract.


The health benefits of slippery elm are rooted mainly in its soothing properties. This mucilaginous herb is effective when used internally for coating and soothing mucous membranes while also absorbing toxins that can cause intestinal imbalances. Slippery elm is an effective remedy for duodenal ulcers, gastritis, diarrhea, colitis, irritable bowel syndrome, hemorrhoids, and heartburn. The benefits of slippery elm also extend to being a simple food. As part of a normal diet, the inner bark of slippery elm can be ground and eaten as porridge. This porridge is extremely nutritious and high in antioxidants having a consistency and taste similar to oatmeal. It is also a wholesome and sustaining food for infants and invalids.


Activated charcoal is charcoal that has been treated with oxygen to open up millions of tiny pores between the carbon atoms. The use of special manufacturing techniques results in highly porous charcoals that have surface areas of 300–2,000 square meters per gram. Charcoal works to trap toxins through “adsorption.” When a material adsorbs something, it attaches to it via chemical attraction. The huge surface area of activated charcoal gives it countless bonding sites for adsorbing toxins.

When certain chemicals pass next to the carbon surface, they attach to the surface and become trapped. Activated charcoal is excellent for trapping carbon-based substances (i.e., organic chemicals), as well as other chemicals such as chlorine. It is known to trap over 20,000 organic chemicals. Many chemicals are not attracted to carbon (sodium, nitrates, etc.) so they pass through charcoal. Because charcoal is not “digested” like food, it may remain inside the GI tract for a time, thereby continuing to actively remove toxins via the bowel.


Research has shown that spirulina promotes digestion and bowel function. It suppresses bad bacteria (including E. coli and Candida albicans yeast) and stimulates beneficial flora, including lactobacillus and bifidobacteria. Healthy intestinal flora (i.e., “good” bacteria) are a foundation for good health. They increase absorption of nutrients from foods and help protect against infection. In Japan, researchers found that spirulina significantly reduces kidney toxicity caused by mercury and three pharmaceutical drugs. This suggests benefits for humans suffering heavy metal poisoning. Additional research found that rats consuming spirulina or chlorella algae eliminated seven times the amount of dioxin (a highly toxic chemical) when compared to a control diet.


Like other types of dietary fiber, inulin also has the benefits of enhancing digestive and intestinal functions, reducing cholesterol, and preventing disease. In addition, inulin has one other major health benefit: it is a prebiotic that feeds the healthy microflora that boost your immunity. Not only does inulin actively promote the growth of existing strains of probiotics in your colon, but it also encourages implantation, survival, and growth of freshly consumed probiotics. By boosting the survival and growth of beneficial probiotics in the inner ecosystem, inulin improves digestion, immunity, and disease-fighting capacity of the body.


Ginger rhizome (Zingiber officinale) is an incredibly active and effective gastrointestinal aid with the following properties: 1) Contains a digestive enzyme whose effectiveness even exceeds that of papain; 2) Stimulates the flow of saliva and increases the concentration of the digestive enzyme amylase in the saliva; and 3) Activates peristalsis and increases intestinal muscle tone. Ginger is also known to be helpful in cases of nausea.


BIOVIN® Grape Pulp, Skin & Seed Extract (>85% OPCs): The BioVin® grape extract in REJUVENATE!™ BERRIES & HERBS is extracted by ethanol and water and contains the highest percentage of OPCs (oligomeric proanthocyanidins) of any product on the market. OPCs, a class of bioflavonoids, are one of nature’s most powerful free-radical scavengers. As bioflavonoids, OPCs help to increase the effectiveness of Vitamin C. OPCs cross the blood-brain barrier to provide antioxidant protection to central nervous system tissue. Studies have clearly demonstrated that OPCs improve and normalize capillary activity, strengthening capillary walls. OPCs bind to collagen fibers, realigning them in the process to a more youthful, undamaged structure. Elasticity, flexibility, and strength are thereby restored to connective tissue.


Licorice root soothes the GI tract and aids intestinal health. Licorice root is used effectively in those individuals suffering from peptic ulcer and chronic gastritis. It is used to soothe coughs and reduce inflammation, soothe and heal ulcers and stomach inflammation, control blood sugar, and to balance hormones. Licorice is a potent antiviral agent and can be used to treat flu, herpes, and even hepatitis. Licorice is also a strong anti-inflammatory agent.

MAGNESIUM (from magnesium ascorbate)

Magnesium is important for the metabolism of many biologically active nutrients and substances, including calcium, potassium, phosphorus, zinc, copper, sodium, lead, cadmium, hydrochloric acid (HCl), acetylcholine, and nitric oxide (NO). It is required for more than 325 magnesium-dependent enzymes, cellular homeostasis, and activation of the B vitamin thiamin. It mediates the functions of the nervous and endocrine systems, supports proper muscle and nerve function, stabilizes heart rhythm, helps to regulate blood sugar levels, and supports normal blood pressure. Magnesium is important in energy metabolism and the synthesis of proteins.


Chlorella Growth Factor (CGF) stimulates lactobaccilus (the “good” bacteria) to grow at four times the usual rate. Experiments with microorganisms, young animals, and children have demonstrated that CGF promotes faster than normal growth. In adults and mature organisms, CGF appears to enhance the functions of nucleic acids at the cellular level that relate to the production of proteins, enzymes, and energy. It also stimulates tissue repair and offers protection against toxic substances at the cellular level.

VITAMIN C (from magnesium ascorbate)

Vitamin C is known to perform many critical functions within the body involving detoxification, tissue building, immune enhancement, pain control, and controlling or killing pathogenic organisms. It is known to be helpful for wound and bone healing, healthy skin and eyes, infections, stress control, toxic exposure, and repairing damaged tissue of all types.


Additional Ingredients: Natural Lemon Flavor, Malic Acid, and Stevia Leaf Extract. These natural flavors and taste enhancers give the formula a pleasing taste and make it easier for individuals to consume.

DIRECTIONS: For long-term, gentle rejuvenation of the intestinal tract take about one (1) teaspoon (about 1/3 scoop) several times daily away from food (by at least 20 minutes), or as directed by a health care professional. Place the powder in about 8 ounces of water, thoroughly mix (shake or stir), and drink immediately (before the formula becomes a gel too thick to easily consume).

For a more rapid healing cleanse take one tablespoon (one scoop) multiple times daily away from food (by at least 45 minutes). Add the powder to about 16 ounces of water, mix vigorously, and drink.

We recommend using a suitable container (such as a mason jar) for rapid mixing. Stir rapidly or shake vigorously (with lid attached).

Individuals suffering from conditions of severe diarrhea and loose stools can take one tablespoon (or more) multiple times daily (five times or more) and refrain from food. Put the powder in about 16 ounces of water per tablespoon, thoroughly mix, and drink immediately. In between servings it may be helpful to take a multiple strain lactic acid bacteria formula (i.e., a soil based probiotic such as Prescript-Assist). Place the formula directly in your mouth, chew, and then swallow.

While results can be obtained rapidly using this formula, it is most effective when used for longer-term gentle cleansing. Starting with lower doses and gradually increasing dosage often produces best results. This allows the body time to adjust to increased dosages (size and frequency) and facilitates greater therapeutic action from usage.

Note: Taking large amounts without sufficient liquid (e.g., water) or when first taking the formula can slow bowel transit time. Therefore, most individuals will benefit from starting at lower dosage levels and ensuring adequate fluid intake when consuming the formula.

External Applications: Make paste by mixing powder with water. Apply directly to skin or affected areas (e.g., stings, bites, wounds). Wrap with gauze, plastic, etc., and keep poultice moist. Use for up to six hours. Apply fresh poultice as needed.

Intestinal Rejuvenation Formula does not contain wheat, gluten, rye, oats, corn, barley, soy, yeast, egg, sugar, dairy products, GMOs, wax, animal fats, preservatives, colorings, or artificial flavorings.



Gut Health – Intestinal Rejuvenation Formula

Dr. Mark Sircus’s blog article at www.DrSircus.com:
“Apples – Pectin – Intestinal Formula”

Kidney Cleansing with Juices & Herbs

Liver Cleanse with Juices & Herbs

Rejuvenation Program: Part 2 (Detoxification)

Death by One (Or Two) Thousand Cuts

Microbiome, Diet, and Prescript-Assist Probiotic and Prebiotic

Chemical / Environmental Toxicity Syndrome Protocol

Super Remedies for Stings and Bites

Understanding Glyphosate Toxicity: Interview with Genetic Engineer Thierry Vrain (Mother Earth News)


The Colon Health Handbook by Robert Gray

Brain Maker: The Power of Gut Microbes to Heal and Protect Your Brain for Life by Dr. David Perlmutter

Grain Brain: The Surprising Truth About Wheat, Carbs, and Sugar – Your Brain’s Silent Killers by Dr. David Perlmutter

Wheat Belly: Lose the Wheat, Lose the Weight, and Find Your Path Back to Health by Dr. William Davis



PRESCRIPT-ASSIST™ Probiotic Formula
(soil-based organisms)

RESTORE For Gut Health

(proteolytic enzymes)

(full spectrum plant enzymes)

Nascent Iodine

Magnesium Oil, Flakes, Gel


Irena Ossola bike racing recovery pH Adjust alkalinizing formulaEditor’s note: HPDI’s sponsored pro cyclist Irena Ossola is a frequent contributor to our blog. Today she writes about her experience with adjusting and monitoring her pH levels using pH Adjust and pH test strips. ~

I have used HPDI’s pH Adjust alkalinizing formula for about two months, and my experience has been quite interesting. I can see how my body reacts on a chemical level to different stresses—such as racing, travel, training, rest, and different foods I eat. I consistently use pH paper to test my pH first thing when I wake up in order to have a more controlled test.

My primary finding is that after a race my body is quite acidic (pH of 6.3). While in contrast after a day of rest and/or dinner consisting of lots of vegetables and spinach my body is quite alkaline (pH of 7.5 to 8).


While in France and racing very hard, I noticed that taking pH Adjust every morning helped my body feel more balanced and avoid spikes of energy or tiredness. I could rest and sleep more deeply, and train with both greater quality and frequency.

Irena Ossola ph test pH Adjust

Wearing my HPDI gear. Products like pH Adjust and Rejuvenate! superfoods keep in me in top condition.

After a month in France of hard racing and training, I began experiencing leg cramping due to the fatigue and travel. I remained consistent in my testing and taking pH Adjust through this difficult period. Initially, my tests were very acidic when the cramps began. Then as my diet consisted of just soup and salad (to hydrate and ease the burden on my digestion/kidneys) the pH test strips showed my pH to be more alkaline.

Also, I read that bicarbonate could help with cramping as it acts as a buffer in the body. So I continued to take the pH Adjust consistently and even increased my doses by adding an evening dose as well, if my afternoon/evening pH test showed my body was acidic (below pH 7).


During the period of cramping I know pH Adjust helped to reestablish an alkaline environment in my body. This is important in order to heal from the cramping which creates a lot of lactic acid and fatigue in my muscles. I noticed the symptoms were reduced. During the cramping stage, I usually have cramping even when walking, but this time it was limited primarily to the bike. I recovered faster and felt better sooner, which I think is a result of the pH Adjust and the correct diet.

test pH paper

Testing pH levels with litmus paper guides my diet and use of pH Adjust.

Even after travel and during my return to harder training I will continue to take pH Adjust as part of my normal routine. There is nothing else available or on the market that acts so specifically to balance the pH within the body. This is so important as we introduce and put many stresses on our body that take it out of balance. Whether it is environmental or nutritional, these stresses can lead to further problems. So simply taking pH Adjust every morning can help protect against these variables. I feel the difference when I am consistent in taking it, and my body is under constant stresses due to my work as a professional cyclist.

pH Adjust

pH Adjust helps me maintain optimal pH levels—there’s nothing else like it.


Last month I returned from Europe where I was suffering from some leg cramping, so I decided to do a body cleanup. I was still taking pH Adjust in the morning and my normal supplements, but I also wanted to do a 3–5 day juice cleanse. This helped the recovery as it cleans out my kidneys and gives my digestion a rest. Whenever I return from travel or racing I try to do a juice cleanse to reboot my system.

Irena Ossola ph test ph adjust

Me and my bike!

The three day juice cleanse ended up being a great flush, and my legs were recovering very well after all the travel, racing, cramping, and stress.

I did notice some feelings of fogginess in my head during the cleanse. But I was told that this is not uncommon to feel as it could be either from the reduced amount of protein entering the body, or because the toxins are being cleaned out of the system, so the mind is also readjusting to this as well.

I have noticed that the more juice cleanses I do, the faster and easier my body adjusts to the fluid diet. I don’t feel hunger, but just craving for the juice and energy. As long as I have enough juice made and on hand, I don’t feel worried about my ability to nourish my body. Without intense training I really enjoy the cleanse and don’t feel the need or cravings for sugar or certain foods. It simplifies life, and allows me to focus on important things like training and my work as a pro cyclist.

Pro Tip: When going through lots of stress on the body like exercise, illness, surgery, polluted environments, etc., increase the amount of Rejuvenate! superfoods in your diet and eat sardines. Both of these nutritional components will help speed up recovery time, and battle any incoming hazards and risk factors to your body.

irena ossola rejuvenate superfoods

Pro Tip: Rejuvenate! superfoods support recovery after training and racing.


(Official website)

Irena Ossola page
(HPDI Reseller site)


Power Juice & Super Smoothie of Pro Cyclist Irena Ossola

Racing on Rejuvenate! Superfoods

Juice Journey of Cyclist Irena Ossola

All About the Balance – Mind, Body, and Nutrition

Resolving 2014 – Cyclist Irena Ossola on Training

Pro Cyclist Irena Ossola’s Rejuvenate! Smoothie

Get Results with Rejuvenate! Superfoods

Introducing Professional Racing Cyclist, Irena Ossola


pH Adjust Alkalining Formula

pH paper
(litmus test paper)

Rejuvenate! superfoods
(comparison chart)



Dr. Hank Liers, PhD leaky gut glyphosateFred Liers PhD leaky gut glyphosateWe recently added a category of products for Gut Health to the HPDI foundational supplements program. We did this not only because there is a documented increase in gut-related health issues, but also because we hear about gut health issues from our clients and resellers. They desire effective means for solving the gut health problems prevalent today.

One of the biggest gut health problems we see today is leaky gut syndrome. The syndrome goes by other names and encompasses various symptoms. These symptoms broadly encompass food allergies, sensitivities, and intolerances.

Yet, the symptoms can also include low energy, fatigue, immune disorders, as well as obesity and blood sugar issues. It also encompasses celiac disease and certain brain disorders.

In fact, most of these gut-related conditions and symptoms today go beyond what was historically meant by “leaky gut syndrome.” Today leaky gut and the conditions associated with it largely seem to relate to a combination of factors, including modern agricultural methods, use of antibiotics and certain other pharmaceuticals, and toxic chemicals in foods and the environment.

glyphosate herbicide spray

Studies show the herbicide glyphosate adversely impacts gut health.


Agriculture was not so long ago an organic affair. Chemical fertilizers were unknown, soils were healthier, and crops were at least non-GMO.

Things got worse with the introduction of chemical fertilizers, herbicides, and pesticides. The green revolution of the 1960s brought more changes, including the rise of monoculture crops and more dependence on chemicals.

Chemicals used in agriculture destroy soil microbes. These chemicals induce plant growth without simultaneously improving the quality of the soil. Consequently, the result is depletion of nutrients in soils. This has been proven by measurable declines in vitamins, minerals, and other nutrients in food crops.

When soils are continuously depleted and are nutrients are not replaced or augmented (as in Biodynamic agriculture, for example), soils have fewer nutrients. Eventually crops grown in these soils will be nutrient-poor and therefore not optimal for health. Nutrient declines in soils are significant, and soils continue to be depleted of nutrients.

The combination of chemical fertilizers, herbicides, and pesticides has created an unsustainable system of agriculture that does not produce nutritious food crops. Herbicides such as 2,4-D and atrazine, and pesticides like DDT (which remains in soils) are examples of chemicals that can significantly harm human and environmental health.

The introduction of genetically modified (GMO) crops has accelerated the negative effects of industrialized farming methods. This is especially true in terms of the lowering soil-quality and adversely impacting soil microbes, reducing nutrient levels in crops, and both directly and indirectly harming human health.

GMO crops have not been properly tested for safety. The dangers of GMO crops are significant. Bt corn is a crop whose genetic modification is associated directly with gut health issues (see charts below). Bt corn was created to damage the intestines of insects, but that also damages the health of the human gut.

When combined with specialized herbicides designed for use on GMO crops, the dangers of GMOs increase significantly. The primary herbicide used for GMO crops is glyphosate, which is a mineral chelator, endocrine disruptor, and biocide with antibiotic effects that kill bacteria (beneficial and harmful) indiscriminately leading to an imbalanced human microbiome.

Glyphosate appears to be associated with an increasing number of adverse health conditions partly because many health problems can be caused or exacerbated by nutrient deficiencies, endocrine disruption, microbiome imbalances, and other toxic effects. These health conditions include leaky gut syndrome which not only may result from an imbalanced microbiome, but also from a loosening of the necessarily tight junctions in the gut wall that protect us from exposure to foreign proteins not unlike the blood-brain barrier protects our brain.


Use of the herbicide glyphosate has increased dramatically in recent years. Glyphosate is the primary (but by no means the only) ingredient in the herbicide RoundUp.

Glyphosate kills plants including weeds, and it does this partly by acting as a mineral chelator that prevents the uptake of nutrients by plants. This starves the plant until it dies. However, plants genetically modified to withstand glyphosate still contain fewer nutrients and are therefore less nutritious.

Moreover, any glyphosate you consume acts as a chelator in your body that  blocks your uptake of minerals and nutrients. This will not be good, especially if the GMO foods you consume are already nutrient deficient. Glyphosate also interferes with how you uptake and process nutrients (like manganese) in ways that guarantee depletion in the body, as will be discussed further below).

gmo crops glyphosate

Source: N. L. Swanson, “Genetically Modified Organisms and the Deterioration of Health in the United States” (2013)

A major reason for increasingly larger applications of glyphosate on crops is the rise of glyphosate-resistant “super weeds.” This was not predicted to happen, but clearly it is happening. Thus, the “solution” to the development of super weeds has been simply to apply more glyphosate. This means greater amounts of poison in crops, and of course, greater profits for the herbicide company.

The problem is that glyphosate is extremely toxic. If there were a perfect storm scenario for herbicide use, then glyphosate would be one component of it. Many scientists are concerned about it, including former genetic engineers like Thierry Vrain, who now advocates growing and consuming organic foods (see more below).

Increased use of glyphosate will in turn accelerate the rise of super-resistant weeds, and accelerate damage to the health of those who consume it.

Not to mention the unknown health risks of the genetically modified (GMO) crops themselves, which are sprayed with glyphosate. How would you be able to tell which is more damaging to health, the toxins embedded in GMO crops or the sprays that soak both GMO and non-GMO crops alike. None have been properly tested, or test results are hidden or suppressed.

Beyond all this, non-GMO crops like wheat, oats, barley, beans, and nuts are routinely sprayed with glyphosate at the end of the season as a means to dry these crops to make harvesting easier. So much for trying to eat verified non-GMO.

You’re likely getting a lot of glyphosate in your diet…unless you eat 100% organically grown foods that are not contaminated with glyphosate by direct spraying, spraying for the purposes of drying, or from drift related to nearby spraying.

And with increased levels of spraying to apply more of this herbicide, the likelihood is you’re getting glyphosate not only from foods, but also from a contaminated water supply (wells, rivers, streams), and from rainfall (with more than 65% of rain samples testing positive).


A noteworthy article on the topic of glyphosate and genetically modified organisms (GMO) is N.L.  Swanson’s “Genetically Modified Organisms and the Deterioration of Health in the United States” (2013). This was originally published as a series of articles on the Seattle Examiner website.

Scientists may disagree on the level of veracity of the article, and quibble over the finer points of statistical correlation. Meanwhile, people are getting sicker, not healthier. And that is the point.

If indeed glyphosate is impacting human health adversely at even a fraction of the levels argued by Swanson, then individuals should reduce their consumption of GMO foods as much as possible to avoid health consequences.

Foods containing GMOs should be clearly labeled, like they are in many other countries. Consumers have a right to know if foods contain GMO. There is no valid objection to labeling since many other (and far less harmful) ingredients in foods are labeled. This is a transparency issue. It is the least consumers deserve.

In July 2016, the US enacted the so-called DARK Act, which requires labels for GMO products. However, this law is far weaker than the Vermont law that preceded it. The US law preempts state laws. It represents a poor attempt to address consumers’ desire for labeling of GMO foods. It offers no standard labeling requirements, nor any means to enforce compliance for companies that fail to label. And while some may consider the US law progress for consumers, consider that in Europe GMO labeling went into effect back in 1997 – nearly 20 years ago.

In addition, proper scientific testing of the health effects of GMOs and in particular the herbicide glyphosate, as well as the adjuvants and surfactants contained in glyphosate-containing products—and how these ingredients act synergistically—must be carried out. Consumers should never be guinea pigs when science is available that can protect them and help them make informed decisions.

Not unlike tobacco companies that suppressed and downplayed the harm of their products, today’s purveyors of agricultural chemicals (and especially GMOs and glyphosate) are not particularly concerned about the adverse health effects of their products. In fact, it appears to be just the opposite, as studies indicating harmful effects frequently have been suppressed.

Several of the studies used to indicate safety of GMOs were short-term studies (three months) conducted by companies who make and sell the products themselves without peer review or release of data. Whereas longer-term, independent studies indicate probable harm to health, therefore showing the precautionary principle was disregarded in approving GMOs for human consumption.

In order for consumer to protect themselves, GMO labeling is a minimum measure. Most nations already require clear labeling or ban GMOs.


The use of antibiotics in livestock results in a tainted food supply. This means that foods ingested contain antibiotics that damage and destroy beneficial microbes in the human gut. This contributes to reduced microbiome diversity and paves the way for a takeover by harmful bacteria.

Then there is the overuse of antibiotics in human medicine. The use of antibiotics significantly damages microbiome health and diversity. The importance of the microbiome for human health is such that antibiotic use that kills beneficial bacteria and imbalances the gut flora is proven to reduce overall health and can contribute to major health problems throughout life. This is especially true when antibiotics are used in childhood when the microbiome is establishing itself.

Glyphosate is not considered an antibiotic per se, but it exerts antibiotic-like effects. That is, glyphosate destroys microbes by acting on the Shikimate pathway, and therefore acts like an antibiotic. This pathway is not present in human beings, but is present in plants and most microbes important for the health of the human gut.

Glyphosate interferes with the synthesis by gut bacteria of aromatic amino acids (including tyrosine and tryptophan) as well as methionine. This leads to shortages in critical neurotransmitters such as serotonin and melatonin as well as folate.

There is evidence to show that glyphosate produces resistance to antibiotic drugs, just as overuse of antibiotics themselves contributes to the increase of so-called “superbugs,” or bacteria resistant to most or all antibiotics. This fact is another reason glyphosate contributes to the health problems relating to antibiotic use and to gut health issues, in particular.

The overuse of antibiotics both in humans and animals is an ongoing problem with many authorities calling for a reduction in use so that antibiotics are not rendered useless by the development of antibiotic-resistant strains of bacteria.

Current policies regarding antibiotics virtually guarantee that not only will microbiome health be harmed by the consumption of antibiotic tainted foods and by the use of antibiotics too easily prescribed, but also that harmful bacteria will become stronger rendering antibiotics less useful in applications where they are truly needed.

An interesting fact in this regard is that Pseudomonas aeruginosa, a gram-negative bacteria, is a major problem in hospitals today due to its resistance to multiple antibiotics. It is one of only three bacterial species that can break down glyphosate. However, it produces formaldehyde as a by-product. Formaldehyde is a well-established neurotoxin. It is likely that the growth of this harmful bacteria is stimulated by the presence of glyphosate in the gut.

Avoidance of antibiotics in foods and when not medically necessary are ways individuals can help keep themselves healthy.


While this article deals primarily with the topic of gut or gastrointestinal health, it is noteworthy that glyphosate is considered to be an endocrine disruptor.

Endocrine disruption is associated with birth defects, reproductive problems (like infertility), breast cancer, and developmental problems in babies and children before and after birth, as well as a host of other health effects.

Endocrine disruptors are common in the environment, and we have written about them in previous posts. Glyphosate’s role as an endocrine disruptor is important not only because it is another harmful element among its many dangers, but also simply because of its ubiquitousness in the environment.

The amount of glyphosate spray in the US and the world in extraordinary. As weeds have become resistant to glyphosate (leading  to the rise of super weeds), the solution has been to spray more of it. Therefore, the amounts to which individuals are exposed have skyrocketed along with the increase in its application on crops and elsewhere.

Also, as noted, the practice of spraying glyphosate as a desiccating agent on non-GMO crops (such as wheat, oats, sugar cane, and peanuts) contributes significantly to human exposure. So too does “household” use in gardens and use by municipalities for spraying to decrease “weeds” in public places, such as parks and schools.


Dr. Stephanie Seneff is a leading researcher in the area of the harmful effects of glyphosate. The following YouTube presentation by Dr. Seneff and Dr. Sachin Patel (interviewer) provides a wealth of information for the reader and is highly recommended: https://www.youtube.com/watch?v=TpoGUPwe40c

In Dr. Seneff’s presentations she has pointed out that the following nutrients, hormones, and neurotransmitters are disrupted by glyphosate:

  1. Folate, Vitamin K, Vitamin A, Vitamin D, and cobalamin (Vitamin B12).
  2. Aromatic amino acids and methionine
  3. Iron, manganese, cobalt, selenium, zinc, and sulfur
  4. Serotonin, melatonin, dopamine, epinephrine
  5. Melanin (skin tanning agent), thyroid hormone
  6. NAD, glutathione (key antioxidant defenses)

Clearly it would be wise to take in foods and nutritional supplements that could replete the body with these  substances.

In order to compensate for these effects of glyphosate Dr. Seneff recommends the following supplements:

  1. Curcumin (see HPDI CURCUMIN C3 COMPLEX)
  2. Garlic
  3. Vitamin C (see HPDI PRO-C™ and Ultimate Protector™)
  4. Probiotics (see Prescript-Assist™)
  5. L-5-Methytetrahydrofolate (see HPDI 5-MTHF)
  6. Vitamin B-12 (see HPDI Methylcobalamin)
  7. Glutathione (contained in HPDI GLU-NAC Plus)
  8. Taurine (contained in HPDI Hepa Plus)


Recently, Dr. Seneff and collaborators have identified the fact that glyphosate – a glycine amino acid based molecule – can disrupt a large number of enzymes in the body by inserting itself into proteins during the synthesis process where glycine would normally be inserted. When this happens, the function of the enzyme is completely negated. For further details see: https://www.youtube.com/watch?v=snNRfAfSeUk


Another class of worrisome genetically modified crops are Bt corn and other Bt crops (cotton, potato, and soy). Note that there are also glyphosate tolerant/resistant strains of corn (maize), so all types of GMO corn are potentially hazardous to health.

Bt corn is a variant of maize genetically altered to express proteins from the bacterium Bacillus thuringiensis. Thousands of different Bt strains exist that produce proteins toxic to insect pests. Particular strains are chosen to target specific plant pests, such at the European Corn Borer (ECB).

 When an insect consumes Bt-containing plant tissues, one or more Bt proteins become activated in its gut, creating toxins that paralyze its digestive system and form holes in its gut wall.

Bt toxins bind to receptors in the insect’s gut. This causes the  gut wall to break down and allows toxins, as well as normal gut bacteria to enter the insect’s body. Toxins and bacteria proliferate in the insect’s body causing death. Notably, many insects have developed resistance to glyphosate, just as have weeds.

It has been noted by commentators that the human digestive system appears to be damaged in a similar way by proteins in Bt corn. In any event, as the number of acres planted with Bt corn increases, it appears that human digestive disorders also increase.

irritable bowel syndrome gut health bt corn

Source: N. L. Swanson, “Genetically Modified Organisms and the Deterioration of Health in the United States” (2013)

Disorders of the digestive system associated with Bt toxins not only include irritable bowel syndrome (IBS) and constipation, but also Crohn’s Disease and Ulcerative Colitis.

inflammatory bowel disease crohn colitis gut bt corn

Source: N. L. Swanson, “Genetically Modified Organisms and the Deterioration of Health in the United States” (2013)

While the effects of the Bt toxin are different than those of glyphosate and other chemicals in glyphosate-containing crop chemicals, the fact is that evidence shows that the Bt toxins appear to adversely impact gut health.


Among key takeaways from examining the literature of problems associated with antibiotic use, as well as with the chemicals associated with modern agriculture and genetically modified foods (i.e., glyphosate and other herbicides, pesticides, and various surfactants and adjuvants used with them): Choose to eat organic foods as much as possible for best health.

Only by consuming organic foods can individually significantly reduce the amount of glyphosate, pesticides, antibiotics, and other harmful chemicals in the diet to support good health in general, and gut health in particular. Organic foods are also more nutrient dense, and therefore more nutritious.

After it is understood how current industrial agricultural methods contribute to damaging human health, then organic foods can be seen as a solution helping ensure avoidance of most or many of harmful elements in foods.

Organically grown foods may be tainted by drift or by toxins in the soil existing before the adoption of organic farming methods. Yet, the amounts of such toxins will be significantly reduced overall by consuming organic foods. The longer-term solution is adoption of organic methods (and corresponding reductions in use of chemicals and GMOs in agriculture) that will result in a cleaner, safer food supply for all.

Some say that organic foods are no better, or cost too much, or do not improve health. But the truth is that they are better, should not cost more, and are far more sustainable for human and planetary health. In fact, at this point in time, consuming organic foods may be the only practical solution for avoiding health problems, especially gut-health problems, associated with industrialized, chemically based agricultural methods.

Growing food yourself is another option, as is purchasing organic or locally grown organically grown produce at your Farmer’s Market. These foods will not be sprayed with toxins and will not suffer the same level of nutrient declines found in conventional produce. Having even a relatively small garden at home will allow you to supplement organic foods you obtain locally. Some neighborhoods support community gardens where you can grow foods organically.

Between consuming foods you grow, purchasing organic or non-sprayed produce locally and/or at natural foods stores, emphasizing grass-fed, free-range animal products (e.g., eggs and meats), and reducing meals at restaurants that serve conventional foods (as well as ordering organic and non-GMO foods whenever possible), you can largely bypass or reduce the toxicity and gut-health issues associated with the toxins and GMOs in foods sold in grocery stores and ubiquitous in our food distribution system.

A 100% organic diet is recommend, entirely possible, and at the very least a worthy goal. It will pay dividends in terms of good health and how you feel.

Others recommend to detoxify from glyphosate by consuming an organic diet.


Wheat stands out as a singular food to avoid. It been hybridized beyond all recognition with many genes being added because wheat genes are additive. The wheat protein gluten has been linked to many types of health problems.

Gluten has long been a problem for gut health. Now with glyphosate being sprayed directly on wheat crops (as well as oats, sugar cane, and peanuts) as a desiccating agent, it seems that opening tight junctions in the gut and then having exposure to gluten is a prescription for disaster.

glyphosate wheat leaky gut intestinal infection

Glyphosate increasingly is sprayed on wheat (a non-GMO crop) for drying before harvest. How does poisoning wheat this way make sense?

Some commentators (like Wheat Belly author William Davis, MD) show that gluten is linked with obesity, diabetes, celiac disease, and many others.

Avoidance of wheat, gluten, and other simple carbohydrates is a good idea if you would maintain and retain good gut health.

celiac glyphosate wheat goo

Celiac disease has significantly increased with the practice of spraying glyphosate on wheat.


In the article “Glyphosate’s Suppression of Cytochrome P450 Enzymes and Amino Acid Biosynthesis by the Gut Microbiome: Pathways to Modern Diseases,” Stephanie Seneff and Anthony Samsel state that there are many pathologies to which glyphosate may contribute:

“The pathologies to which glyphosate could plausibly contribute, through its known biosemiotic effects, include inflammatory bowel disease, obesity, depression, ADHD, autism, Alzheimer’s disease, Parkinson’s disease, ALS, multiple sclerosis, cancer, cachexia, infertility, and developmental malformations.” (Entropy 201315(4), 1416-1463; doi:10.3390/e15041416)


Industrial agriculture, including the practices associated with the cultivation of GMO crops, harms the soils and human health.

Dangers to human health from industrial agriculture and GMOs includes harm to gastrointestinal health. This encompasses many conditions, including Leaky Gut Syndrome.

Leaky gut does not always result from a single cause, but can involve multiple factors, including exposure to glyphosate (and its adjuvants), Bt toxins, depleted nutrient levels, wheat and wheat protein (gluten/gliadin) exposure, microbiome imbalances or disruption, antibiotic use or consuming foods containing antibiotics, other chemical exposures, and additional factors.

Ways to avoid leaky gut: 1) Consume a 100% organic diet, 2) Avoid GMOs, 3) Avoid antibiotics, 4) Maintain a healthy microbiome, 5) Avoid wheat and simple carbohydrates (and simple sugars), 6) Improve nutrient levels through diet and dietary supplements, 7) Use specific supplements that help restore and maintain gut health 7) Detoxify on a regular basis using juices, herbs, and other practices.

We will continue writing articles for blog series on the topic of gut health. In coming months, we will write about various means for improving gastrointestinal structure and function. These means include restoring tight junctions in the gut using Restore (lignite formula).



Center For Food Safety (CFS)

Institute for Responsible Technology (IRT)

The Detox Project (Glyphosate Portal)


Glyphosate-based herbicides are toxic and endocrine disruptors in human cell lines

Genetically Modified Organisms and the Deterioration of Health in the United States“, N. L. Swanson, MIT

Glyphosate’s Suppression of Cytochrome P450 Enzymes and Amino Acid Biosynthesis by the Gut Microbiome: Pathways to Modern Diseases

Plants have a microbiome just like humans — and it could transform how our food is produced

Understanding Glyphosate Toxicity: Interview with Genetic Engineer Thierry Vrain (Mother Earth News)


Gut Health – Intestinal Rejuvenation Formula

Amending the HPDI Foundational Supplement Program

Microbiome, Diet, and Prescript-Assist Probiotic and Prebiotic

Kidney Cleansing with Juices & Herbs

Liver Cleanse with Juices & Herbs

Rejuvenation Program: Part 2 (Detoxification)

Death by One (Or Two) Thousand Cuts

Dr. Mark Sircus’s blog article at www.DrSircus.com:
“Apples – Pectin – Intestinal Formula”


Brain Maker: The Power of Gut Microbes to Heal and Protect Your Brain for Life by Dr. David Perlmutter

Grain Brain: The Surprising Truth About Wheat, Carbs, and Sugar – Your Brain’s Silent Killers by Dr. David Perlmutter

Wheat Belly: Lose the Wheat, Lose the Weight, and Find Your Path Back to Health by Dr. William Davis




PRESCRIPT-ASSIST™ Probiotic Formula (soil-based organisms)

RESTORE For Gut Health (lignite formula)

(proteolytic enzymes)

(full spectrum plant enzymes)

Nascent Iodine

Magnesium Oil, Flakes, Gel



Dr Hank Liers PhD science behind MegahydrateI recently became aware of the health benefits of molecular hydrogen/hydrogen. We subsequently have written numerous blog articles on the subject (see resources section below), and elected to carry and endorse several products, including Active H2 and Megahydrate™. As a scientist, I am particularly impressed with the science behind Megahydrate, as well as the in-depth research studies carried out showing how it was developed and its health benefits.

For economic reasons, it is rare for a particular nutritional supplement to have in-depth scientific studies and clinical trials supporting its use. In this article, I will present some of the most relevant scientific information regarding Megahydrate.

 science behind Megahydrate

In a previous article “Water, Hydration, and Crystal Energy®” I discuss in-depth the science behind Dr. Patrick Flanagan’s use of nanometer-sized silica colloids to enable greater hydration of the body, enhanced absorption of nutritional ingredients into cells, and improved cellular detoxification.

In this article I will discuss the science and benefits of embedding hydrogen anions (hydride or H-) into these same nanometer-sized silica colloids that not only have all of the hydration benefits of Crystal Energy® but also exhibit potent antioxidant characteristics. The resulting substance is named by Dr. Flanagan “silica hydride” and his product that incorporates it is known as Megahydrate™ (originally Microhydrin™). The science behind the development of Megahydrate is provided below.


The details of the materials development are provided in an article by Cory J. Stephenson and G. Patrick Flanagan titled “Synthesis of Novel Anionic Hydride Organosiloxane Presenting Biochemical Properties” published in the International Journal of Hydrogen Energy 28 (2003) 1243–1250.

Synthesis of an anionic hydride from monomeric silsesquioxanes is described. The novel compound, dubbed “silica hydride” is the result of several newly synthesized compounds from an interstitially embedded hydride family. It is a hydride-based compound with H− ions interstitially embedded in a matrix of caged silica. This compound exhibits profoundly different characteristics than other known compounds in the hydride family. Unlike saline hydrides, the silica hydride demonstrates no overt or violent reaction with water or air. However, it is capable of generating aqueous reductive potential readings (ORP) of −750 mV for extended time periods. In vitro biological testing demonstrated no cytotoxicity induced by the compound while demonstrating efficacy as an antioxidant. In vivo studies of the compound have shown that it has a significant ability to reduce lactic acid build up in muscles by one-half after exercise. The synthesis of the silica hydride resulted in an approximately 16.8% w/w hydride content, as determined by density changes, proton NMR spectroscopy and ion beam analyses. Scanning and tunneling electron microscopy, Rutherford backscattering spectroscopy (RBS), forward recoil (FReS) ion beam analyses, in addition to Fourier transform infrared spectroscopy, reduction potential and 29Si CP-MAS solid state NMR were additionally used to characterize the compound.

Below relevant details from the article are provided to give insight into the science of the Megahydrate invention.

Introduction: The idea behind synthesis of the novel compound described in this article is based on the use of a monomer nanocomposite as a carrier in a bioencapsulated compound. The synthesis uses a silica and hydroxyl group terminated silsesquioxane monomer, trademarked Silica Microclusters®, that is interstitially imbedded with hydride anions as conceptually depicted in Fig. 1. The results from the characterization of this compound provide evidence to this claim, including DRIFTS FTIR and NMR data.

Figure 1 science behind Megahydrate

Figure 1. Conceptual diagram of Flanagan Microcluster structure. The tetrahedral coordination forms a three-dimensional framework by a series of Si–O–Si bonds, creating a silica cage.

With the immense potential for bioencapsulates and nanocomposite technologies, it would be very beneficial to create a hydride out of a compound that would involve the combinational reducing effects of a saline hydride compound and the beneficial attributes of the host compound, all without the reactivity of the saline hydrides. Synthesizing a biologically friendly hydride would have immense potential as an antioxidant and radical scavenger as discussed later in this paper.

It was discovered in the present work that if a hydride ionic plasma was placed under pressure, virtually any compound it came in contact with could then absorb its emitted ions. Since the 1920s, creating a hydride gas has been standard practice. One effective way is to add a current to a tungsten (W) lament in a hydrogen gas atmosphere. The lament separates hydrogen gas into a monovalent hydrogen gas while the photoelectric effect on the W lament donates electrons to the H gases forming a H− plasma. Langmuir, in 1927, while using the W lament hydride ion synthesis technique, discovered that moist air prevents hydride ions from recombining back into hydrogen gas.

Figure 2 science behind Megahydrate

Figure 2. The Concept of Silica Hydride. Conceptually the hydride embedded organosiliceous silsesquioxane, or silica hydride, is a monomeric silica-based cage with interstitially placed hydride anions. As a bioencapsulated compound, the silica acts as a colloidal carrier for the hydrogen anions in solution.

Details of Invention: The idea for this synthesis experiment was to then create a hydride plasma under a water vapor atmosphere and expose the plasma to an organosilicate compound, circumventing the problem of the hydrogen not having the catalysis or the electron availability to combine with the host substrate. Interestingly, Langmuir noted that the monoatomic ions produced by this process would become embedded in the glass walls of the tubing of his apparatus and that same tubing could later be induced to release the ions. The glass tubing used by Langmuir was a borosilicate glass, an amorphous siliceous compound. In the present study, an apparatus similar to what Langmuir used was constructed to create a plasma of H− ions. The H− atmosphere was applied to the pure Microcluster Silica powder under pressure and in the presence of a water vapor, creating a novel silsesquioxane bioencapsulated-hydride compound, dubbed: silica hydride.

Materials and methods: A 1.0 L sealed glass vessel was fabricated containing the items as depicted in Fig. 3. Two 5 cm × 0:6 cm diameter W rods were positioned transversely 2 mm apart in the top of the reaction vessel with two insulated leads connecting the W rods to a 20 A constant-current transformer (Lambda-EMI 102A-1KV, Neptune, NJ). Ten grams of MicroclusterJ silica was placed on the stage inside the vessel with 100 ml of distilled and deionized water added to the basin. A steady stream of hydrogen gas was bubbled through an aquarium stone in water and introduced to the reaction vessel, purging all of the air from the vessel and increasing pressure to 172 kPa at which time the vessel was sealed. A 500 V potential was applied to the W rods. At voltages ranging from 350 to 750 V, a constant arc could be maintained between the electrodes without melting. The potential was applied for 30 seconds at which time the current was shut off  and additional hydrogen was pumped into the vessel creating a captive plasma. The sample was allowed to sit in the plasma for 30 minutes at which time the silica sample was removed and weighed with an analytical balance.

Figure 3 science behind Megahydrate

Figure 3. Synthesis Apparatus. The representation of the apparatus used to synthesize the compound. A hydrogen gas generator (A) provides H2 gas that is sparged through a fllter stone in deionized, distilled water (B), where the hydrogen gas and water vapor are transported into a reaction vessel (C) with the substrate. Two tungsten electrodes (D) create a captive plasma H− gas via a constant current high-voltage power supply (E). Vessel evacuation, purge and sealing were performed using a mechanical valve (F). The resultant actions interstitially embed the hydride anions created by the plasma into the substrate.

Results: Determination of the mass of the anionic hydride organosiloxane sample showed an increase from 10.0 to 11.70 g upon exposure to the hydride plasma under pressure. The sample was allowed to sit at room temperature with desiccant in a glass vial for 3 weeks at open atmosphere at which time the proceeding analyses were performed.

An ion beam analysis was performed with the silica powder being pressed into a pellet (1.66 g/cm3) compared to a control standard. Rutherford backscattering spectroscopy (RBS) was analyzed with 2 MeV He beam, while 3 MeV He beam was used in a forward-recoil spectrometry (FReS) measurement. RBS suggests that the powder contains elements O and Si. Including H- content by FReS, the powder relative percentage makeup becomes H (78.1%), O (15.6%) and Si (6.2%). Trace amounts of boron (B) and W (<25 ppm) were also observed. Original values from samples of non-reacted Microcluster silica comparatively illustrate an elemental makeup of H (22.4%), O (55.6%) and Si (21.9%). A 1H-NMR characterization was performed and showed a 16.8% hydride content.

Scanning electron microscopy analysis with a 40 KeV-JEOL 840II microscope illustrated small, ∼ 2 microns, spheres consisting of numerous smaller spheres. A 300 KeV-CM30 transmission electron microscope allowed the resolution to image very small, spherical compounds that were measured to be about 50 Angstroms. An energy dispersive X-ray spectrometer qualified an elemental analysis of the compound to contain Si and O.

The ORP and pH were recorded for 250 ml distilled and deionized water in a Pyrex beaker. 10.0 g/ml of the siliceous hydride was added to the beaker and allowed to stir for 15 min at which time addition ORP and pH readings were taken. The initial ORP and pH of the water averaged 341.33±2.5 mV and pH 7.12±0.06, respectively. The readings after 15 min were −436.21 ± 2.1 mV for the ORP and 9.13 ± 0.09 for the pH measurements.

The hydrogen pressure unbiased reducing potential, rH, was calculated. The use of rH gives a hydrogen proton-unbiased look at the absolute reducing potential of a compound, eliminating the effects of pH in the ORP measurement. The measured rH for the compound was 11.02 ± 0.04 indicating a highly reduced environment.

Discussion: The synthesis process appears to cluster the organosilicate subunits into hydrogen-bonded aggregates that further group into approximately 2 micron clusters as shown in Fig. 4A. Dissolution in water decreases the cluster size from 2 microns to the smaller subunits of about 500 nm, then into individual cages of about 50 A (Fig. 4B).

 Figure 4 science behind Megahydrate


This new organosilicate silsesquioxane compound, commonly named silica hydride, has been the subject of numerous tests involving reduction potential (ORP) and pH as well as being analyzed as an effective antioxidant. Adding a few mg to water will drop an ORP reading by −750 mV. A recent publication of a clinical study has illustrated the capability of this compound to significantly reduce lactic acid after exercise by 50%. Viability and cytotoxicity probes show that the silica hydride does not cause any decrease in intracellular esterase activity or otherwise induce a toxic cytoplasmic environment. There are a plethora of uses of a hydride-based compound such as silica hydride since it does not impose a direct negative effect to cellular viability and cytoplasmic health. Particular uses include nutritional supplementation as an antioxidant. The incredible reduction potential of silica hydride adds to the possible uses of this type of compound.

The compound does not react violently or visibly with H2O. However, it will reduce the ORP reading to −750 mV for a period of at least several weeks. Most antioxidant compounds are relatively large chemical species. Examples of this are vitamins A, K, C, ubiquinone and n-acetyl-l-cysteine. It is hypothesized that steric hindrances may affect the efficacy of antioxidants. The small size and reducing capacity of silica hydride, the silsesquioxane hydride compound, may lead to future development as an antioxidant.

Conclusion: The novel siliceous compound acts as a colloidal carrier for the very small hydride anions that are released in an aqueous solution. This nanosized colloidal bioencapsulated compound could be an incredibly effective radical scavenger and aid in the reduction of oxidative stress due to its minimal size and high reduction potential.

This novel compound presented in this paper has demonstrated promising in vitro and in vivo biochemical significance with uses including reducing agents, antioxidants and nutritional supplementation. The synthesis is simple and effcient with consistent results of about 17% w/w hydride content with respect to the starting compound. Biologically friendly compounds that incorporate health-beneficial minerals, such as silica, with the scavenging and reducing capabilities of a hydride provide for numerous possibilities of uses.


After inventing Megahydrate (formerly Microhydrin), Dr. Flanagan (and his associates) conducted studies on its efficacy for a range of benefits for human health. The material was then patented in 2003. Key elements of the patent are provided below and a link to the entire content is provided if you wish to read further details.

Methods of using silica hydride mineral
US 20030190374 A1


The exact health benefits of silica hydride minerals, traditionally found in glacial streams, have long been the subject of speculation. Geochemical analysis indicates that such colloidal silica hydrides in water possess a silica-water interface that provides a hydrated surface and adsorbs other elements or compounds such as potassium, iron, magnesium, lithium, calcium, and hydrogen. Dietary supplements with similar properties have been formulated. When the silica-water interface of such compounds is saturated with reduced hydrogen, the compounds take on an overall negative charge and act as a reducing agent or antioxidant when in solution. When consumed, hydride ions introduced into the body by the silica hydride supplement donate electrons to body fluids. With proper dosages, the benefits of consuming silica hydride include reduction of lactic acid build-up, increasing cellular hydration, reduction of free radical damage, enhancement of mitochondrial bioenergetic capacity, increasing antioxidant activity, and enhancing the properties of drinking water.


This invention relates to methods of using silica hydride minerals. More particularly, this invention relates to methods of using silica hydride minerals that have beneficial effects on lactic acid buildup during exercise, cellular hydration, free radical damage, mitochondrial bioenergetic capacity, antioxidant activity, and the suitability of water for conversion into optimal cellular body fluids.

Amorphous silicate minerals, many of which are in the nanoparticle size range, were once common in natural water sources and abundant in glacial stream waters. Not only do the silica mineral particles bond water and other elements for transport; they also can be adsorbed with reduced hydrogen, which releases electrons, providing antioxidant or reducing potential to surrounding fluids.

In one region of West Pakistan the people are known to enjoy excellent health and amazing longevity. A team of cardiologists found the heart health of the people to be exceptionally good and evidence of the people’s delayed aging. The cardiologists attributed the good health and longevity in significant part to the abundance of colloidal silicate minerals in the glacial streams the people used for irrigation of food crops and drinking water.

Geochemical analysis indicates that colloidal silicate minerals display a variety of properties, including the formation of structured water around the silica-water interface, which provides a hydrated surface that adsorbs elements or compounds such as potassium, iron, magnesium, lithium, calcium, and hydrogen. FIG. 5 illustrates an example of the silica-water interface and the concentric structured water arrangement about the interface with the adsorption of elements within the layers.

Figure 5 science behind Megahydrate

Figure 5. An enlarged view of a hypothetical silica hydride particle showing the silica-water interface and other adsorbed elements.


From silicate analogs, it is possible to formulate dietary supplements that are similar to the colloidal silicate minerals found in glacial waters and retain the geo-physical properties inherent to these minerals. An example of such synthesized silicate analogs is a silica hydride formula sold under the trademark Microhydrin®. Substances possessing the characteristics and functions described in this application, such as Microhydrin®, have assumed many names.

For example, in addition to being called silica hydrides, such substances are known as amorphous silicate minerals, silicate particles, silicates, colloidal silicate minerals, silicate analogs, synthesized silicate analogs, functional silicate nanocolloids, dielectric interstitial hydrides, dietary silicate supplements, or dietary silicate antioxidants. Considering the many labels afforded this class of substances, the characteristics and functions of supplements must necessarily determine whether a particular supplement falls within the class.

Referring again to FIG. 5, the particle’s silica-water interface can be saturated with reduced hydrogen, or hydride (H-) ions, and takes on an overall negative charge. In such cases, the particle then acts as a reducing agent or antioxidant when in solution (standard reduction-oxidation potential, −550 mV). It is capable of providing literally trillions of hydride ions able to donate electrons into body fluids.

Electrons, which Albert Szent-Gyorgyi called the “fuel of life,” are abundantly available in inorganically grown raw vegetables, fruits, and grains, but are deficient in our modem diet of over-cooked, acidic, or highly oxidized foods, beverages, and drinking water. In silica hydride minerals, the structured water around the silica-water interface stabilizes electron transfer. Such specific silicate interactions could play a substantial role in many biological processes by enhancing salvation properties and ion and water transport and by providing free radical antioxidant protection.

Such electron deficiencies resulting from inadequate diet have a derogatory impact on specific biological processes such as lactic acid build-up, cellular hydration, damage from free radicals, mitochondrial bioenergetic capacity, antioxidant activity, and suitability of drinking water for conversion into optional cellular body fluids. Therefore, a need exists for a method of counter balancing these electron deficiencies and, as a result, enhancing each of these biological phenomena.

The present invention identifies certain beneficial health effects of silica hydride minerals and the effective doses necessary to achieve desired results. With proper dosages, the benefits of using silica hydride minerals as a dietary supplement include: reduction of lactic acid buildup during and after exercise, increasing cellular hydration, reduction of free radical damage, enhancement of mitochondrial bioenergetic capacity, increasing antioxidant activity, and enhancing the suitability of water for conversion into optimal cellular body fluids.


1. A method of reducing lactic acid buildup during and after exercise comprising ingesting an effective dose of silica hydride mineral.
2. A method of increasing cellular hydration comprising ingesting an effective dose of silica hydride mineral.
3. A method of reducing free radical damage comprising ingesting an effective dose of silica hydride mineral.
4. A method of enhancing mitochondrial bioenergetic capacity comprising ingesting an effective dose of silica hydride mineral.
5. A method of increasing antioxidant activity comprising ingesting an effective dose of silica hydride mineral.
6. A method of making water more suitable for conversion into optimal extracellular and intracellular body fluids comprising ingesting water mixed with an effective dose of silica hydride mineral.
7. A method of improving the characteristics of body fluids, such as saliva pH, saliva rH2, blood resistivity, urine resistivity, urine pH, urine rH2, and saliva resistivity comprising ingesting an effective dose of silica hydride mineral.


  • Contains Hydrating Silica Microclusters®
  • Extremely Powerful Antioxidant
  • Recycles other Key Antioxidants in the Body
  • Extremely Safe and Non-Toxic
  • Easily Accesses All Cells in the body
  • Increases Cellular ATP Production by up to a factor of 4 times
  • Readily Converts NAD+ to NADH
  • Reduces Pain & Inflammation
  • Exhibits Powerful Anti-Aging Properties
  • Protects and Repairs DNA
  • Neutralizes Harmful Toxins like Fluoride, Chlorine, etc.
  • Protects Against and Repairs Radiation Damage
  • Increases Absorption of other Supplements
  • Lowers surface tension of water you drink leading to improved detoxification
  • Removes Heavy Metals from the Body
  • Balances pH or Alkalizes the body
  • Increases Zeta Potential of Human Cells
  • Increases Cellular Hydration
  • Very Stable – Works Over Extensive Time Periods
  • Reduces Lactic Acid Buildup During Intense Workouts
  • Protects Telomeres by allowing cells to exceed the Hayflick limit by 4-5 times


Molecular Hydrogen Foundation (MHF)

Hydrogen for Optimal Health
by Fred Liers, PhD (from the HPDI blog)

Wonders of Molecular Hydrogen
by Fred Liers, PhD (from the HPDI blog)

Molecular Hydrogen (H2) at the Forefront of Health Research
by Hank Liers, PhD (from the HPDI blog)

ACTIVE H2 (tablet)

H2BEV (bottle)

MegaHydrate™ (capsule)

Contact Us:

You can reach HPDI by calling 1-800-228-4265, email support(at)IntegratedHealth.com, or visit the retail website: www.IntegratedHealth.com

Health care professionals and retailers can apply for wholesale account, which includes access to the HPDI reseller website: www.HealthProductsDistributors.com