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PREVENTING FREE RADICAL DAMAGE WITH ULTIMATE PROTECTOR+

Back in 2012, I learned about Nrf2 activators and was excited about pursuing the development of a supplement that would incorporate the new knowledge we were learning into a effective product for preventing free radical damage. At that time, I published two articles: New Directions for Preventing Free Fadical Damage and Natural Phytochemical Nrf2 Activators for Chemoprevention. I started working on a new Nrf2-activator formula I called Ultimate Protector that incorporated many of the ideas contained in these articles. The product was introduced November 2012.

More recently, in early 2019, I decided to upgrade the product using new information and ingredients. The upgraded product is called Ultimate Protector+. In this article, I provide new details of our design logic and product ingredients. I expect the new formula to be released in July 2019.

Ultimate Protector+

Ultimate Protector+ is new and improved!

PREVENTING FREE RADICAL DAMAGE WITH ULTIMATE PROTECTOR+

Ultimate Protector+™ is a unique cell protection formula that simultaneously meets the needs for high levels of non-GMO Vitamin C, full spectrum antioxidants (high ORAC values), and protective enzyme activators (Nrf2 activators) in a single product. This potent combination of characteristics distinguishes the formula because no other single product available today offers such complete protection. This is the single best formula for preventing free radical damage that is available.

Ultimate Protector+™ provides extremely high levels of natural antioxidants, including high levels of ingredients such as polyphenols, flavonoids, anthocyanidins, oligomeric proanthocyanidins, catechins, curcuminoids, pterostilbene, resveratrol, chlorogenic acid, punicalagins, zeaxanthin and other carotenoids that act powerfully as antioxidants. These antioxidants come from more than 12 plant-based ingredients with demonstrated free-radical quenching capacity. These “exogenous” food-based antioxidants (supplied from outside the body) provide you with immense oxidative defenses that can be used to defend against free-radical assault.

Ultimate Protector+™ contains USP-grade non-GMO Vitamin C , SFB® standardized fruit blend (~50% polyphenols, high-ORAC powder: 9,000 µmole TE/g) from Grape, Cranberry, Pomegranate, Blueberry, Apple, Mangosteen, Bilberry, Chokeberry, and Goji Berry), Curcumin (standardized extract with 95% curcuminoids), Trans-Resveratrol (98% from Giant Knotweed), Green Tea Extract (90% polyphenols, 50% EGCG), VinCare® Whole Grape Extract (>80% polyphenols, ORAC>19,000 µmole TE/g), Calcium Malate, Magnesium Malate, and Bioperine® (a patented black pepper extract that enhances absorption of all ingredients and is a known Nrf2 activator).

Ultimate Protector+™ is contained in a capsule suitable for vegetarians (i.e., a veggie cap) and contains no magnesium stearate.

NUTRITIONAL CONSIDERATIONS AND APPLICATIONS

Ultimate Protector+™ satisfies three distinct needs:

1) The need for a non-GMO Vitamin C product. That is, a Vitamin C formula that avoids protein from genetically modified sources such as corn, potatoes, or beets.

2) The need for a single, powerful antioxidant formula for preventing free radical damage. That is, a single, easy-to-take antioxidant formula offering a broad range of extremely high-ORAC plant source antioxidants. These antioxidants should protect against the full range of free radicals found in the human body including: superoxide anion (O2·-), peroxyl radicals (ROO·), hydroxyl radicals (HO·), singlet oxygen (1O2), and peroxynitrite (ONOO-).

3) The need for a supplement providing a full spectrum of Nrf2 activators. That is, a supplement providing a wide range of natural Nrf2 transcription factor activators that allow the body to make its own antioxidant enzymes (e.g., superoxide dismutase (SOD), catalase, hemeoxygenase, and glutathione peroxidase). Scientific research has shown that these are found naturally in many fruits, vegetable, and herbs. These ingredients provide a wide range of Nrf2 activators that result in significantly high levels of the endogenously produced antioxidant enzymes.

The ways Ultimate Protector+™ satisfies these three needs are discussed below:

1) NON-GMO VITAMIN C / ASCORBIC ACID

High-quality, USP grade Vitamin C has been obtained historically from corn, potatoes, and/or beets. Unfortunately, many of these sources have to a large extent gone to genetically modified (GMO) variants. However, with highly refined production methods and the use of PCR testing, we have been able to obtain final products that are free from GMOs.

In nature, Vitamin C is found generally in plant sources containing polyphenols. Vitamin C and polyphenols work together to provide a high level of antioxidant protection and they support the function of each other in the process. For example, Vitamin C is needed by the body to produce collagen and certain polyphenols (especially oligomeric proanthocyanidins) (OPCs) crosslink the collagen and make it stronger.

2) EXTREMELY HIGH ORAC SOURCES

Free radicals are reactive species that can have adverse effects on normal physiological functions. Studies associate the five major types of free radicals (i.e., hydroxyl, peroxyl, peroxynitrite, singlet oxygen, and superoxide anion) with health conditions such as cardiovascular disease, hypertension, breakdown of vital proteins, chronic inflammation, Alzheimer’s disease, and certain cancers. Avoiding free radical damage is the goal.

Antioxidants function as a vital line of defense against free radicals by blocking their attack on DNA, vital proteins, lipids, and amino acids. Until now, efforts to identify the effect of antioxidants on all five types of free radicals were constrained by limited testing procedures. However, new technological developments have resulted in a comprehensive testing method called the Total ORAC5.0™ assay. Because of the development of the Total ORAC5.0™ test, it is now possible to target and measure the effects of antioxidants on the five major types of free radicals found in the body.

We are currently in the process of testing Ultimate Protector+™ using this new ORAC5.0™ assay. We are confident that our formula offers protection against these five major types of free-radicals because we combine a wide range of extremely high-ORAC fruit, vegetable, and herbal blends. As soon as the results are available (in July 2019), we will update this article with the findings.

3) NRF2 TRANSCRIPTION FACTOR ACTIVATORS

In order to survive under a variety of environmental or intracellular stresses, our cells have developed highly efficient protective mechanisms to protect themselves from oxidative or electrophilic challenges. Proteins that comprise phase II detoxification and antioxidant enzymes provide an enzymatic line of defense against reactive oxygen species (ROS). These enzymes include superoxide dismutase (SOD), catalase, glutathione peroxidase, glutathione S-transferase (GST), and glutamate cysteine ligase.

Induction of phase II and antioxidant enzymes are regulated at the DNA/gene level by an antioxidant responsive element (ARE). ARE-mediated gene expression plays a central role in the cellular defense against cellular oxidative damage. Experimental evidence supports the view that induction of ARE-mediated cytoprotective enzymes is a critical and sufficient mechanism to enable protection against disease provoked by environmental and endogenous insults.

One of the key ARE-binding transcription factors is Nrf2. Induction of cytoprotective enzymes in response to ROS, electrophiles, and phytochemicals is a cellular event that is highly dependent on Nrf2 protein. By activating Nrf2 signaling, phytochemicals can increase cellular detoxification and antioxidant enzymes, thereby enhancing removal of ROS and toxic chemicals and preventing disease. Numerous research studies carried out over the last 15 years have demonstrated the effectiveness of a very wide range of Nrf2 activators extracted from fruits, vegetables, and herbs.

For example, a study with sulforaphane (an isothiocyanate present abundantly in cruciferous vegetables) shows that oral administration of this phytochemical can effectively block benzo[a]pyrene-induced forestomach tumors in mice. This protective effect was abrogated in mice that could not produce Nrf2. This supports the critical role of phase II detoxification and antioxidant enzymes in the prevention of carcinogenesis by chemopreventive agents.

Nrf2 is normally bound in the cytoplasm of cells to a protein called KEAP1. However, when an appropriate phytochemical agent attaches to a kinase receptor on the cell wall a phosphate group is released that causes the Nrf2 to be released. Also, there are other mechanisms that allow Nrf2 to be released from KEAP1. The released Nrf2 then migrates into the cell nucleus and causes an antioxidant enzyme (e.g., superoxide dismutase (SOD)) to be fabricated and released. This endogenously produced enzyme then can protect against ROS, electrophiles, and other toxic agents.

In practical experience, it has been found that a combination of multiple polyphenols works significantly better than single ingredients. In fact, in one experiment it was found that a combination of five ingredients all known to be Nrf2 activators was 18 times more effective than any single ingredient. Furthermore, it was found that this combination of five ingredients was able to increase levels of SOD by 30% and catalase by 56% after 120 days of taking the combination.

In view of the considerations above, we include a wide range of Nrf2 activators in Ultimate Protector+™. These include a large variety of freeze-dried and concentrated fruits, vegetables, and herbs. These include Grape, Cranberry, Pomegranate, Blueberry, Apple, Mangosteen, Bilberry, Chokeberry, Goji Berry), Curcumin (standardized extract with 95% curcuminoids), Trans-Resveratrol (98% from Giant Knotweed), Green Tea Extract (93% polyphenols, 50% EGCG), VinCare® Whole Grape Extract (>80% polyphenols, ORAC>19,000 µmole TE/g)

Ultimate Protector+™ includes the following phytonutrients in its array of freeze-dried and concentrated fruits, vegetables, and herbs: polyphenols, flavonoids, anthocyanins, catechins, proanthocyanins, ellagic acid, xanthines, chlorogenic acid, pterostilbenes, resveratrol, phloridzin, quercetin, zeaxanthin, carotinoids, polysaccharides, quinic acid, and more.

The phytochemical ingredients in Ultimate Protector+™ are discussed below:

1. SFB® – (Standardized Fruit Blend)

SFB® is a nutritious, non-GMO blend that provides a broad spectrum of polyphenols, anthocyanins, and other antioxidants derived from water and/or ethanol extracts of grape (Vitis vinifera), cranberry (Vaccinium macrocarpon), pomegranate (Punica granatum) with >75% polyphenols, blueberry (Vaccinium uliginosum), apple (Malus pumilla Mill), mangosteen (Garcinia mangostana), bilberry (Vaccinium myrtillis), chokeberry (Aronia arbutifolia), and goji berry (Lycium barbarum). This powder has an ORAC value in excess of 9,000 µmole TE/g and contains 50% polyphenols.

Polyphenols and anthocyanins are not all created equal. Every fruit, vegetable and herb provides its own set of unique polyphenols and anthocyanins that reside in the body for different lengths of time and in different locations, providing a range of benefits. SFB® has been designed to provide a wide range of plant polyphenols, flavonoids, anthocyanins, catechins, OPCs, zeaxanthin and other carotinoids, etc. Published research associates these plant ingredients with healthy aging, inflammation management, improved blood sugar metabolism, and cardiovascular disease management.

SFB® provides the following benefits: Superior source of natural antioxidants and Nrf2 activators, helps ameliorate the effects of premature aging, promotes cardiovascular health, promotes healthy brain function and mental acuity, promotes healthy vision, promotes healthy blood sugar levels, and is an excellent source of flavonoids and organic acids.

I have prepared detailed blog articles for the ingredients in SFB®. Below some of these are summarized and links to the articles are provided.

a) Cranberry Extract

Ultimate Protector+ Includes Cranberry

Ultimate Protector+ Includes Cranberry Extract

Cranberry extract is an especially good source of antioxidant polyphenols. In animal studies, the polyphenols in cranberries have been found to decrease levels of total cholesterol and so-called “bad” cholesterol. Cranberries may also inhibit the growth of tumors in human breast tissue and lower the risk of both stomach ulcers and gum disease.

Here is a list of the antioxidant and anti-inflammatory phytonutrients in found in cranberry extract.

Type of Phytonutrient Specific Molecules
Phenolic Acids hydroxybenzoic acids including vanillic acids;
—Phenolic Acids (cont.) hydroxycinnamic acids inculding caffeic,
—Phenolic Acids (cont.) coumaric, cinnamic, and ferulic acid
Proanthocyanidins epicatechin oligomers
Anthocyanins cyanidins, malvidins, and peonidins
Flavonoids quercetin, myricetin, kaempferol
Triterpenoids ursolic acid

OTHER CRANBERRY INFORMATION

    • Cranberries hold significantly high amounts of phenolic flavonoid phytochemicals called oligomeric proanthocyanidins (OPC’s). Scientific studies have shown that consumption of the berries have potential health benefits regarding cancer, aging and neurological diseases, inflammation, diabetes, and bacterial infections.
    • Antioxidant compounds in cranberry extract including OPC’s, anthocyanidin flavonoids, cyanidin, peonidin and quercetin may support cardiovascular health by counteracting against cholesterol plaque formation in the heart and blood vessels. Further, these compounds help the human body lower LDL cholesterol levels and increase HDL-good cholesterol levels in the blood.
    • Scientific studies show that cranberry juice consumption offers protection against gram-negative bacterial infections such as E.coli in the urinary system by inhibiting bacterial-attachment to the bladder and urethra.
    • It is known that cranberries turns urine acidic. This, together with the inhibition of bacterial adhesion helps prevent the formation of alkaline (calcium ammonium phosphate) stones in the urinary tract by working against proteus bacterial-infections.
    • In addition, the berries prevent plaque formation on the tooth enamel by interfering with the ability of the gram-negative bacterium, Streptococcus mutans, to stick to the surface. In this way cranberries helps prevent the development of cavities.
    • The berries are also good source of many vitamins like vitamin C, vitamin A, ß-carotene, lutein, zea-xanthin, and folate and minerals like potassium, and manganese.
  • Oxygen Radical Absorbance Capacity (ORAC) demonstrates cranberry at an ORAC score of 9584 µmol TE units per 100 g, one of the highest in the category of edible berries.

b) Pomegranate Extract

Ultimate Protector+ Includes Pomegranate

Ultimate Protector+ Includes Pomegranate

For thousands of years, the pomegranate has been extensively used as a source of food and medicine. Full of antioxidants, vitamin C and potassium, pomegranate has been used to control body weight, reduce cholesterol, fight against cell damage, and inhibit viral infections. Pomegranate extracts have anti-bacterial effects.

Pomegranates are rich in ellagic acid, gallic acid, lignans, polyphenols and other bioactive compounds, and have been shown to lower blood pressure and enhance vascular function. Furthermore, it can offset some of the negative effects of medications and chemicals. These compounds occur naturally in its peel, seeds, leaf and juice. The seeds are high in p-coumaric acid, plant sterols, tannins and fatty acids. In addition to their antihypertensive effects, they may help reduce blood sugar levels.

Pomegranate fruit is a rounded berry with a thick reddish skin covering approximately 200–1400 white to deep red or purple seeds. Pomegranate seeds are edible and hold strong antioxidant and anti-inflammatory properties due to their high content of hydrolysable tannins and anthocyanins. As compared to the antioxidant activity of vitamin E, β-carotene, and ascorbic acid, the pomegranate antioxidants appear unique due to combinations of a wide array of polyphenols, having a broader range of action against several types of free radicals. As compared to the recognized antioxidants in red wine and green tea, anthocyanins from pomegranate fruit possess significantly higher antioxidant activity.

Pomegranate has been used in various medicinal systems of medicine for the treatment and therapy of a multitude of diseases and ailments. In the ancient Indian medicinal system, i.e., in Ayurvedic medicine, the pomegranate was considered to be a whole pharmacy unto itself. It was recommended to be used as an antiparasitic agent and to treat diarrhea and ulcers. The medicinal properties of pomegranate have sparked significant interest in today’s scientific community as evidenced by the scientific research relating to health benefits of pomegranate that have been published in last few decades.

Studies have shown that pomegranate and its constituents can efficiently affect multiple signaling pathways involved in inflammation, cellular transformation, hyperproliferation, angiogenesis, initiation of tumorigenesis, and eventually suppressing the final steps of tumorigenesis and metastasis. The pomegranate constituents are shown to modulate transcription factors, pro-apoptotic proteins, anti-apoptotic proteins, cell cycle regulator molecules, protein kinases, cell adhesion molecules, pro-inflammatory mediators, and growth factors.

c) Chokeberry (Aronia)

Ultimate Protector+ Includes Chokeberry

Ultimate Protector+ Includes Chokeberry

HEALTH BENEFITS OF CHOKEBERRY (ARONIA)

Aronia melanocarpa (black chokeberry) has attracted scientific interest due to its deep purple, almost black pigmentation that arises from dense contents of polyphenols, especially anthocyanins. Total polyphenol content is 1752 mg per 100 g in fresh berries, anthocyanin content is 1480 mg per 100 g, and proanthocyanidin concentration is 664 mg per 100 g. These values are among the highest measured in plants to date.

The plant produces these pigments mainly in the leaves and skin of the berries to protect the pulp and seeds from constant exposure to ultraviolet radiation and production of free radicals. By absorbing UV rays in the blue-purple spectrum, leaf and skin pigments filter intense sunlight, serve antioxidant functions and thereby have a role assuring regeneration of the species.

Analysis of polyphenols in chokeberries has identified the following individual chemicals (among hundreds known to exist in the plant kingdom): cyanidin-3-galactoside, cyanidin-3-arabinoside, quercetin-3-glycoside, epicatechin, caffeic acid, delphinidin, petunidin, pelargonidin, peonidin, and malvidin.All these except caffeic acid are members of the flavonoid category of phenolics.

In a standard measurement of antioxidant strength, the oxygen radical absorbance capacity or ORAC, demonstrates aronia to have one of the highest values yet recorded for a fruit — 16,062 micro moles of Trolox Eq. per 100 g. The components contributing to this high measurement were both anthocyanins and proanthocyanidins, with the proanthocyanidin level “among the highest in foods”, which may explain their potent astringent taste.

d) Goji Berry

Ultimate Protector+ Includes Goji Berry

Ultimate Protector+ Includes Goji Berry

Goji Berries contain abundant polysaccharides (LBPs, comprising 5%–8% of the dried fruits), scopoletin (6-methoxy-7-hydroxycoumarin, also named chrysatropic acid, ecopoletin, gelseminic acid, and scopoletol), the glucosylated precursor, and stable vitamin C analog 2-O-β-D-glucopyranosyl-L-ascorbic acid, carotenoids (zeaxanthin and β-carotene), betaine, cerebroside, β-sitosterol, flavonoids, amino acids, minerals, and vitamins (in particular, riboflavin, thiamin, and ascorbic acid).

The predominant carotenoid is zeaxanthin, which exists mainly as dipalmitate (also called physalien or physalin). The content of vitamin C (up to 42 mg/100 g) in goji berry (also known as wolfberry) is comparable to that of fresh lemon fruits. As to the seeds, they contain zeaxanthin (83%), β-cryptoxanthin (7%), β-carotene (0.9%), and mutatoxanthin (1.4%), as well as some minor carotenoids.

In fact, increasing lines of experimental studies have revealed that L. barbarum berries have a wide array of pharmacological activities, which is thought to be mainly due to its high LBPs content. Water-soluble LBPs are obtained using an extraction process that removes the lipid soluble components such as zeaxanthin and other carotenoids with alcohol. LBPs are estimated to comprise 5%–8% of LBFs and have a molecular weight ranging from 24 kDa to 241 kDa. LBPs consist of a complex mixture of highly branched and only partly characterized polysaccharides and proteoglycans.

The glycosidic part accounts, in most cases, for about 90%–95% of the mass and consists of arabinose, glucose, galactose, mannose, rhamnose, xylose, and galacturonic acid. LBPs are considered the most important functional constituents in LBFs. Different fractions of LBPs have different activities and the galacturonic acid content is an imperative factor for activities of LBP. The bioactivities of polysaccharides are often in reverse proportion with their molecular weights. Increasing lines of evidence from both preclinical and clinical studies support the medicinal, therapeutic, and health-promoting effects of LBPs.

e) Mangosteen

Ultimate Protector+ Includes Mangosteen

Ultimate Protector+ Includes Mangosteen

The Mangosteen extract in Ultimate Protector+ has been extracted with non-GMO food grade ethanol and distilled water. Testing has indicated the product contains over 10% polyphenols.

Mangosteen extract in obtained from the skin and whole fruit for which numerous biological activities have been reported including: antimutagenic, antibacterial, hypocholesterolemic, antioxidant, and protective against tumorigenesis.

Mangosteen contains nutrients with antioxidant capacity, such as vitamin C and folate. Plus, it provides xanthones — a unique type of plant compound known to have strong antioxidant properties. In several test-tube and animal studies, the antioxidant activity of xanthones has resulted in anti-inflammatory, anticancer, anti-aging, heart protective, and antidiabetic effects.

Additionally, some research suggests that certain plant compounds in mangosteen may have antibacterial properties — which could benefit your immune health by combating potentially harmful bacteria. In a 30-day study in 59 people, those taking a mangosteen-containing supplement experienced reduced markers of inflammation and significantly greater increases in healthy immune cell numbers compared to those taking a placebo.

f) Apple Extract

Ultimate Protector+ Includes Apple

Apples contain a large concentration of flavonoids, as well as a variety of other phytochemicals, and the concentration of these phytochemicals may depend on many factors, such as cultivar of the apple, harvest and storage of the apples, and processing of the apples. The concentration of phytochemicals also varies greatly between the apple peels and the apple flesh.

Some of the most well studied antioxidant compounds in apples include quercetin-3-galactoside, quercetin-3-glucoside, quercetin-3-rhamnoside, catechin, epicatechin, procyanidin, cyanidin-3-galactoside, coumaric acid, chlorogenic acid, gallic acid, and phloridzin. Recently researchers have examined the average concentrations of the major phenolic compounds in six cultivars of apples. They found that the average phenolic concentrations among the six cultivars were: quercetin glycosides, 13.2 mg/100 g fruit; vitamin C, 12.8 mg/100 g fruit; procyanidin B, 9.35 mg/100 g fruit; chlorogenic acid, 9.02 mg/100 g fruit; epicatechin, 8.65 mg/100 g fruit; and phloretin glycosides, 5.59 mg/100 g fruit.

The compounds most commonly found in apple peels consist of the procyanidins, catechin, epicatechin, chlorogenic acid, phloridzin, and the quercetin conjugates. In the apple flesh, there is some catechin, procyanidin, epicatechin, and phloridzin, but these compounds are found in much lower concentrations than in the peels. Quercetin conjugates are found exclusively in the peel of the apples. Chlorogenic acid tends to be higher in the flesh than in the peel.

Because the apple peels contain more antioxidant compounds, especially quercetin, apple peels may have higher antioxidant activity and higher bioactivity than the apple flesh. Research showed that apples without the peels had less antioxidant activity than apples with the peels. Apples with the peels were also better able to inhibit cancer cell proliferation when compared to apples without the peels. More recent work has shown that apple peels contain anywhere from two to six times (depending on the variety) more phenolic compounds than in the flesh, and two to three times more flavonoids in the peels when compared to the flesh. The antioxidant activity of these peels was also much greater, ranging from two to six times greater in the peels when compared to the flesh, depending on the variety of the apple. This work is supported a study which found that rats consuming apple peels showed greater inhibition of lipid peroxidation and greater plasma antioxidant capacity when compared to rats fed apple flesh.

Many of these phytochemicals from apples have been widely studied, and many potential health benefits have been attributed to these specific phytochemicals. The procyanidins, epicatechin and catechin, have strong antioxidant activity and have been found to inhibit low density lipoprotein (LDL) oxidation in vitro. In mice, catechin inhibits intestinal tumor formation and delays tumors onset. One study found that chlorogenic acid has very high alkyl peroxyl radical (ROO•) scavenging activity. Compared to about 18 other antioxidant compounds (including quercetin, gallic acid, α-tocopherol), chlorogenic was second only to rutin. Since ROO• may enhance tumor promotion and carcinogenesis, chlorogenic acid may add to the protective effect of apples against cancer. Chlorogenic acid has been found to inhibit 8-dehydroxy-deoxyguanosine formation in cellular DNA in a rat model following treatment with 4-nitroquinoline-1-oxide.

Quercetin is also a strong antioxidant, and is thought to have potential protective effects against both cancer and heart disease. Briefly, quercetin has been found to down regulate expression of mutant p53 in breast cancer cells, arrest human leukemic T-cells in G1, inhibit tyrosine kinase, and inhibit heat shock proteins. Quercetin has protected Caco-2 cells from lipid peroxidation induced by hydrogen peroxide and Fe2+. In mice liver treated with ethanol, quercetin decreased lipid oxidation and increased glutathione, protecting the liver from oxidative damage. Recently, it has been found that high doses of quercetin inhibit cell proliferation in colon carcinoma cell lines and in mammary adenocarcinoma cell lines, but at low doses quercetin increased cell proliferation (20% in colon cancer cells and 100% in breast cancer cells). However, low doses of quercetin (10 uM) inhibited cell proliferation in Mol-4 Human Leukemia cells and also induced apoptosis. Quercetin inhibited intestinal tumor growth in mice, but not in rats. Low levels of quercetin inhibited platelet aggregation, calcium mobilization, and tyrosine protein phosphorylation in platelets. Modulation of platelet activity may help prevent cardiovascular disease.

g) Blueberry and Bilberry Extract

wild bilberry and wild blueberry
Wild bilberry and wild blueberry provide Nrf2 activators.

The key compounds in bilberry fruit are called anthocyanins and anthocyanosides. These compounds help build strong blood vessels and improve circulation to all areas of the body. They also prevent blood platelets from clumping together (helping to reduce the risk of blood clots), and they have antioxidant properties (preventing or reducing damage to cells from free radicals). Anthocyanins boost the production of rhodopsin, a pigment that improves night vision and helps the eye adapt to light changes.

Bilberry fruit is also rich in tannins, a substance that acts as an astringent. The tannins have anti-inflammatory properties and may help control diarrhea.

Bilberries have been shown to have the highest Oxygen Radical Absorbance Capacity (ORAC) rating of more than 20 fresh fruits and berries. The antioxidant properties of bilberries were shown to be even stronger than those of cranberries, raspberries, strawberries, plums, or cultivated blueberries.

The antioxidant powers and health benefits of bilberries and blueberries can be attributed to a number of remarkable compounds contained in them, including the following:

  • Anthocyanins
    • malvidins
    • delphinidins
    • pelargonidins
    • cyanidins
    • peonidins
  • Hydroxycinnamic acids
    • caffeic acids
    • ferulic acids
    • coumaric acids
  • Hydroxybenzoic acids
    • gallic acids
    • procatchuic acids
  • Flavonols
    • kaempferol
    • quercetin
    • myricetin
  • Other phenol-related phytonutrients
    • pterostilbene
    • resveratrol
  • Other nutrients
    • lutein
    • zeaxanthin
    • Vitamin K
    • Vitamin C
    • manganese

2) Curcumin

Ultimate Protector+ Includes Curcumin

Ultimate Protector+ Includes Curcumin

We have included Curcumin (95% curcuminoids in ULTIMATE PROTECTOR™. This ingredient contains three main chemical compounds – Curcumin, Demethoxycurcumin and Bisdemethoxycurcumin – collectively known as Curcuminoids and all derived from Turmeric. Curcumin has been shown to be one of the most potent Nrf2 transcription factor activators. Studies have reported that curcumin and turmeric protect the liver against several toxicants both in vitro and in vivo. A number of reports showed the curative action of turmeric and curcuminoids. Curcumin is a potent scavenger of free radicals such as superoxide anion radicals, hydroxyl radicals, and nitrogen dioxide radicals. It exerts powerful antioxidant and anti-inflammatory properties.


3) Trans-Resveratrol (98% from Polygonum cuspidatum – giant knotweed)

giant knotweed resveratrol

Knotweed (Polygonum cuspidatum) is a major source for resveratrol.

Trans-resveratrol provides antioxidant protection, boosts cellular energy, and balances the immune system. It has been proven in studies to activate the SIRT1 longevity gene and enhance cellular productivity. Several research studies have shown that trans-resveratrol activates Nrf2 transcription factor, significantly modulates biomarkers of bone metabolism, inhibits pro-inflammatory enzymes such as COX-1 and COX-2, and exhibits cardioprotective effects, neuroprotective properties, and caloric restrictive behavior. Trans-resveratrol has shown the ability to increase the number of mitochondria thereby increasing total daily energy. Studies have shown that trans-resveratrol promotes an increase in mitochondrial function. Increased mitochondrial function translates into an increase in energy availability, improved aerobic capacity, and enhanced sensorimotor function. Trans-resveratrol has an ORAC value of 31,000 µmole TE/g.


4) Green Tea Extract

Ultimate Protector+ Includes Green Tea Extract

Ultimate Protector+ Includes Green Tea Extract

Green Tea Extract contains highly bioavailable bioflavonoid complexes that in research studies have been shown to have powerful antioxidant capability. Green tea extract is obtained from the unfermented leaves of Camellia sinensis for which numerous biological activities have been reported including: cell protective, antimicrobial, and antioxidant. The green tea extract in Ultimate Protector is extracted is extracted by non-GMO ethanol and distilled water and contains ~ 90% polyphenols and 50% epigallocatechingallate (EGCG).

Epigallocatechin gallate (EGCG) is the most abundant catechin compound in green tea. It is well established that EGCG is a potent antioxidant and anti-inflammatory agent. Epidemiological studies show that consumption of 100 or more mg of EGCG per day is beneficial, as it is the most potent Nrf2 activator among all green tea catechins. EGCG exhibits robust diffusion through bodily tissues, including the endothelium of the blood brain barrier.

EGCG has the capacity to activate Nrf2/ARE and induce Heme oxygenase-1 (HO-1) expression. Several studies have shown that EGCG can also interact with kinases, causing the disassociation of Nrf2/Keap1 complex.

Protective effects of EGCG have been reported against ischemia/reperfusion injury. Administration of EGCG showed improved neurologic scores, reduced infarct volume, and ameliorated neuronal apoptosis due to increased GSH biosynthesis (via Nrf2 activation) and decreased ROS content. By inducing the expression of Nrf2 and HO-1, EGCG increases important endogenous antioxidants in microglial cells.

5) VinCare® whole grape extract (seed, pulp, and skin)

Ultimate Protector+ Includes Whole Grape Extract

Ultimate Protector+ Includes Whole Grape Extract

Whole Grape Extract contains highly bioavailable bioflavonoid complexes that in research studies have been shown to have powerful antioxidant capability. The Oligomeric Proanthocyanidins (OPCs) in grape extract are able to strengthen collagen fibers in aging or damaged connective tissue and can act as a preventative against connective tissue degradation. Some research indicates that anthocyanidins, which are found in extracts of grape seed, skin, and stems (but not in grape seed extract), can reduce oxidized glutathione while at the same time become reduced themselves. In addition, extracts of grape skin and pulp (but not those of grape seed extract) contain trans-resveratrol that has been shown to have cell protective effects.

Grape seed extract has been reported to demonstrate a remarkable spectrum of biological, pharmacological and therapeutic properties against oxidative stress. The antioxidative activities of grape seed extract have been found to be much stronger than those of vitamins C and E. Studies have indicated that grape seed extract showed a protective effect on cardiovascular disease, nephropathy, atherosclerosis, and neuropathy, among other conditions.

Vincare® contains ~80% polypnenols and has an ORAC value of about 19,000 µmole TE/g. ORAC 5.0 testing of grape seed extract exhibits one of the highest values of any tested material at about 100,000 µmole TE/g.

It has been shown that grape seed OPCs activate nuclear erythroid2-related factor2 (Nrf2), which is a key antioxidative transcription factor, with the concomitant elevation of downstream hemeoxygenase-1 (HO-1). Click here to view an excellent article entitled Proanthocyanidins [OPCs] against Oxidative Stress: From Molecular Mechanisms to Clinical Applications.

7) Bioperine®:

Bioperine® is a black pepper extract that has been shown to enhance the absorption of nutrients by 30–60 percent and makes all of the nutrients in this product more effective.

Ultimate Protector+™ will be most effective when used in conjunction with other foundational nutritional supplements that support the body’s metabolism, including Multi Two or Mighty Multi-Vite!™ (therapeutic multivitamin formulas), Omega Plus (essential fatty acids with Vitamin E), PRO-C™ (antioxidant formula), and one of our high-RNA Rejuvenate!™ superfoods.

COMPOSITION: six veggie capsules provides the following percentages of the Daily Value:

Serving Size: 6 Veggie Capsules Servings per Container: 30
Amount Per Serving Amounts % Daily Value
Vitamin C (as 100% USP-grade, non-GMO ascorbic acid) 1,500 mg 1667%
Calcium (from calcium malate) 60 mg 6
Magnesium (from magnesium malate) 60 mg 15
SFB®† (50% polyphenols, Orac: 9,000 units/gm) 180 mg *
Curcumin (95% min. curcuminoids from Curcuma longa) (root) 135 mg *
Green Tea extract (92% polyphenols, 50% EGCG) 135 mg *
Trans-Resveratrol 98% 135 mg *
Vincare®† whole grape extract (80% polyphenols, Orac: 19,000 units/gm) 135 mg *
Bioperine®†† 7.5 mg *
*
* Daily Value not established

Other ingredients: vegetarian capsule (veggie cap), microcrystalline cellulose, silica, and ascorbyl palmitate.

Directions for Use: As a dietary supplement take two capsules three times daily with food, or as directed by a health care professional.

ULTIMATE PROTECTOR Does Not Contain: wheat, rye, oats, barley, corn, gluten, soy, egg, dairy, yeast, sugar, shellfish, GMOs, wax, preservatives, colorings, or artificial flavorings.

ULTIMATE PROTECTOR+™ will be most effective when used in conjunction with other foundational nutritional supplements that support the body’s metabolism, including Multi Two or Mighty Multi-Vite!™ (therapeutic multivitamin formulas), Essential Fats plus E (essential fatty acids with Vitamin E), PRO-C™ (antioxidant formula), and one of our high-RNA Rejuvenate!™ superfoods.

†SFB® and VinCare® are registered trademark of Ethical Naturals, Inc.

†† Bioperine® is a registered trademark of Sabinsa Corporation.

ADDITIONAL RESOURCES

New Directions for Preventing Free-Radical Damage

Natural Phytochemical Nrf2 Activators for Chemoprevention

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ULTIMATE PROTECTOR+ INGREDIENTS – CRANBERRY

Dr. Hank Liers, PhD biography about us HPDI integratedhealth formulator founder CEO scientist physicist wild bilberry and wild blueberryUltimate Protector+ contains cranberry extract, as well as components from 12 different fruits, vegetables, and herbs. Each of these ingredients contain substances that may be considered to be polyphenols, antioxidants, and Nrf2 activators. In this article I will explore the ingredient cranberry, which is a component of SFB® – Standardized Fruit Blend from Ethical Naturals, Inc.

Ultimate Protector+ Includes Cranberry

Ultimate Protector+ Includes Cranberry Extract

SFB® – Standardized Fruit Blend

SFB® is a proprietary formula that combines extracts from Grape, Cranberry, Pomegranate, Blueberry, Apple, Mangosteen, Bilberry, Chokeberry, and Goji Berry. It is high in fruit polyphenols, flavonoids, anthocyanins, catechins, proanthocyanins, ellagic acid, xanthines, chlorogenic acid, pterostilbenes, resveratrol, phloridzin, quercetin, zeaxanthin, carotenoids, polysaccharides, quinic acid, and more. With its diverse blend, SFB® offers over 40-50% polyphenols as well as >9,000 ORAC units in a single gram.

Polyphenols, anthocyanins and other plant elements are powerful ingredients associated with a variety of areas of human health, including healthy aging, healthy glucose metabolism, cardiovascular health, and inflammation management.

HEALTH BENEFITS OF CRANBERRIES

Cranberries (Vaccinium macrocarpon) are native to the boggy regions of temperate and subalpine North America and Europe. Although Native Americans used them extensively, they were first cultivated in the U.S. in the early 19th century. Cranberries grow on viney plants belonging to the heath family Ericaceae that also includes blueberries, bilberries, huckleberries, and bearberries (Arctostaphylos uva ursi). Cranberries contain tannins, fiber, anthocyanins (and other flavonoids), and Vitamin C. Their tannins prevent bacteria from attaching to cells. Consequently, cranberries have been used against infections, including urinary tract infections. In addition, cranberries may be helpful in protecting against heart disease and stroke.

Cranberry extract is an especially good source of antioxidant polyphenols. In animal studies, the polyphenols in cranberries have been found to decrease levels of total cholesterol and so-called “bad” cholesterol. Cranberries may also inhibit the growth of tumors in human breast tissue and lower the risk of both stomach ulcers and gum disease. 

Here is a list of the antioxidant and anti-inflammatory phytonutrients in found in cranberry extract.

Type of Phytonutrient             Specific Molecules
Phenolic Acids                             hydroxybenzoic acids including vanillic acids;
—Phenolic Acids (cont.)             hydroxycinnamic acids inculding caffeic,
—Phenolic Acids (cont.)             coumaric, cinnamic, and ferulic acid
Proanthocyanidins                     epicatechins
Anthocyanins                              cyanidins, malvidins, and peonidins
Flavonoids                                   quercetin, myricetin, kaempferol
Triterpenoids                              ursolic acid

OTHER CRANBERRY INFORMATION

    • Cranberries hold significantly high amounts of phenolic flavonoid phytochemicals called oligomeric proanthocyanidins (OPC’s). Scientific studies have shown that consumption of the berries have potential health benefits against cancer, aging and neurological diseases, inflammation, diabetes, and bacterial infections.
    • Antioxidant compounds in cranberry extract including OPC’s, anthocyanidin flavonoids, cyanidin, peonidin and quercetin may prevent cardiovascular disease by counteracting against cholesterol plaque formation in the heart and blood vessels. Further, these compounds help the human body lower LDL cholesterol levels and increase HDL-good cholesterol levels in the blood.
    • Scientific studies show that cranberry juice consumption offers protection against gram-negative bacterial infections such as E.coli in the urinary system by inhibiting bacterial-attachment to the bladder and urethra.
    • It is known that cranberries turns urine acidic. This, together with the inhibition of bacterial adhesion helps prevent the formation of alkaline (calcium ammonium phosphate) stones in the urinary tract by working against proteus bacterial-infections.
    • In addition, the berries prevent plaque formation on the tooth enamel by interfering with the ability of the gram-negative bacterium, Streptococcus mutans, to stick to the surface. In this way cranberries helps prevent the development of cavities.
    • The berries are also good source of many vitamins like vitamin C, vitamin A, ß-carotene, lutein, zea-xanthin, and folate and minerals like potassium, and manganese.
  • Oxygen Radical Absorbance Capacity (ORAC) demonstrates cranberry at an ORAC score of 9584 µmol TE units per 100 g, one of the highest in the category of edible berries.

For more information on cranberries visit: http://www.whfoods.com/genpage.php?tname=foodspice&dbid=145

SCIENTIFIC STUDIES ON THE ANTIOXIDANT EFFECTS OF CRANBERRIES

Below, I provide relevant scientific studies on the antioxidant effects and potential health benefits of cranberries.

PREVENTION OF OXIDATIVE STRESS, INFLAMMATION AND MITOCHONDRIAL DYSFUNCTION IN THE INTESTINE BY DIFFERENT CRANBERRY PHENOLIC FRACTIONS.

ABSTRACT

Cranberry fruit has been reported to have high antioxidant effectiveness that is potentially linked to its richness in diversified polyphenolic content. The aim of the present study was to determine the role of cranberry polyphenolic fractions in oxidative stress (OxS), inflammation and mitochondrial functions using intestinal Caco-2/15 cells. The combination of HPLC and UltraPerformance LC®-tandem quadrupole (UPLC-TQD) techniques allowed us to characterize the profile of low, medium and high molecular mass polyphenolic compounds in cranberry extracts. The medium molecular mass fraction was enriched with flavonoids and procyanidin dimers whereas procyanidin oligomers (DP > 4) were the dominant class of polyphenols in the high molecular mass fraction. Pre-incubation of Caco-2/15 cells with these cranberry extracts prevented iron/ascorbate-mediated lipid peroxidation and counteracted lipopolysaccharide-mediated inflammation as evidenced by the decrease in pro-inflammatory cytokines (TNF-α and interleukin-6), cyclo-oxygenase-2 and prostaglandin E2. Cranberry polyphenols (CP) fractions limited both nuclear factor κB activation and Nrf2 down-regulation. Consistently, cranberry procyanidins alleviated OxS-dependent mitochondrial dysfunctions as shown by the rise in ATP production and the up-regulation of Bcl-2, as well as the decline of protein expression of cytochrome c and apoptotic-inducing factor. These mitochondrial effects were associated with a significant stimulation of peroxisome-proliferator-activated receptor γ co-activator-1-α, a central inducing factor of mitochondrial biogenesis and transcriptional co-activator of numerous downstream mediators. Finally, cranberry procyanidins forestalled the effect of iron/ascorbate on the protein expression of mitochondrial transcription factors (mtTFA, mtTFB1, mtTFB2). Our findings provide evidence for the capacity of CP to reduce intestinal OxS and inflammation while improving mitochondrial dysfunction.

 CHEMICAL CHARACTERIZATION AND CHEMO-PROTECTIVE ACTIVITY OF CRANBERRY PHENOLIC POWDERS IN A MODEL CELL CULTURE. RESPONSE OF THE ANTIOXIDANT DEFENSES AND REGULATION OF SIGNALING PATHWAYS

ABSTRACT

Oxidative stress and reactive oxygen species (ROS)-mediated cell damage are implicated in various chronic pathologies. Emerging studies show that polyphenols may act by increasing endogenous antioxidant defense potential. Cranberry has one of the highest polyphenol content among commonly consumed fruits. In this study, the hepato-protective activity of a cranberry juice (CJ) and cranberry extract (CE) powders against oxidative stress was screened using HepG2 cells, looking at ROS production, intracellular non-enzymatic and enzymatic antioxidant defenses by reduced glutathione concentration (GSH), glutathione peroxidase (GPx) and glutathione reductase (GR) activity and lipid peroxidation biomarker malondialdehyde (MDA). Involvement of major protein kinase signaling pathways was also evaluated. Both powders in basal conditions did not affect cell viability but decreased ROS production and increased GPx activity, conditions that may place the cells in favorable conditions against oxidative stress. Powder pre-treatment of HepG2 cells for 20 h significantly reduced cell damage induced by 400 μM tert-butylhydroperoxide (t-BOOH) for 2 h. Both powders (5–50 μg/ml) reduced t-BOOH-induced increase of MDA by 20% (CJ) and 25% (CE), and significantly reduced over-activated GPx and GR. CE, with a significantly higher amount of polyphenols than CJ, prevented a reduction in GSH and significantly reduced ROS production. CJ reversed the t-BOOH-induced increase in phospho-c-Jun N-terminal kinase. This study demonstrates that cranberry polyphenols may help protect liver cells against oxidative insult by modulating GSH concentration, ROS and MDA generation, antioxidant enzyme activity and cell signaling pathways.

CRANBERRY EXTRACT SUPPRESSES INTERLEUKIN-8 SECRETION FROM STOMACH CELLS STIMULATED BY HELICOBACTER PYLORI IN EVERY CLINICALLY SEPARATED STRAIN BUT INHIBITS GROWTH IN PART OF THE STRAINS

From: http://www.sciencedirect.com/science/article/pii/S1756464613000364

ABSTRACT

It is known that cranberry inhibits the growth of Helicobacter pylori (HP). In human stomach, HP basically induces chronic inflammation by stimulating stomach cells to secrete interleukin (IL)-8 and other inflammatory cytokines, and causes stomach cancer, etc. The aim of this study was to investigate the inhibiting effects of cranberry on HP growth and IL-8 secretion from stomach cells induced by HP, using clinically separated HP strains. HP growth in liquid culture and on-plate culture was evaluated by titration after 2-day incubation and by agar dilution technique, respectively. For IL-8 experiments, MKN-45, a stomach cancer cell line, was incubated with HP for 24 h and IL-8 in the medium was assayed by ELISA. Cranberry suppressed growth of the bacteria only in six of the 27 strains. Meanwhile, it suppressed IL-8 secretion in all the strains. The results may suggest a possible role of cranberry in prevention of stomach cancer by reducing gastric inflammation.

EFFECTS OF CRANBERRY POWDER ON BIOMARKERS OF OXIDATIVE STRESS AND GLUCOSE CONTROL IN DB/DB MICE

From: http://www.ncbi.nlm.nih.gov/pubmed/24353827

ABSTRACT

Increased oxidative stress in obese diabetes may have causal effects on diabetic complications, including dyslipidemia. Lipopolysccharides (LPS) along with an atherogenic diet have been found to increase oxidative stress and insulin resistance. Cranberry has been recognized as having beneficial effects on diseases related to oxidative stress. Therefore, we employed obese diabetic animals treated with an atherogenic diet and LPS, with the aim of examining the effects of cranberry powder (CP) on diabetic related metabolic conditions, including lipid profiles, serum insulin and glucose, and biomarkers of oxidative stress. Forty C57BL/KsJ-db/db mice were divided into the following five groups: normal diet + saline, atherogenic diet + saline, atherogenic diet + LPS, atherogenic diet + 5% CP + LPS, and atherogenic diet + 10% CP + LPS. Consumption of an atherogenic diet resulted in elevation of serum total cholesterol and atherogenic index (AI) and reduction of high density lipoprotein (HDL)-cholesterol. However, with 10% CP, the increase in mean HDL-cholesterol level was close to that of the group with a normal diet, whereas AI was maintained at a higher level than that of the group with a normal diet. LPS induced elevated serum insulin level was lowered by greater than 60% with CP (P < 0.05), and mean serum glucose level was reduced by approximately 19% with 5% CP (P > 0.05). Mean activity of liver cytosolic glutathione peroxidase was significantly increased by LPS injection, however it was reduced back to the value without LPS when the diet was fortified with 10% CP (P < 0.05). In groups with CP, a reduction in mean levels of serum protein carbonyl tended to occur in a dose dependent manner. Particularly with 10% CP, a reduction of approximately 89% was observed (P > 0.05). Overall results suggest that fortification of the atherogenic diet with CP may have potential health benefits for obese diabetes with high oxidative stress, by modulation of physical conditions, including some biomarkers of oxidative stress.

SUMMARY

Cranberry extract is full of polyphenols, anthocyanins, antioxidants, and Nrf2 activators that help to make Ultimate Protector+ such an outstanding nutritional supplement.

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ULTIMATE PROTECTOR+ INGREDIENTS – GOJI BERRY

Dr. Hank Liers, PhD biography about us HPDI integratedhealth formulator founder CEO scientist physicist wild bilberry and wild blueberry Ultimate Protector+ includes goji berry extract (also known as wild fresh goji berry fruit powder extract and wolfberry extract), as well as extracts from 12 different fruits, vegetables, and herbs. Each of these ingredients contain substances that may be considered to be polyphenols, antioxidants, and Nrf2 activators. In this article, I will explore the ingredient goji berry (Lycium barbarum) extract which is a component of SFB® – Standardized Fruit Blend from Ethical Naturals, Inc.

Ultimate Protector+ Includes Goji Berry

Ultimate Protector+ Includes Goji Berry

SFB® is a proprietary formula that combines extracts from Grape, Cranberry, Pomegranate, Blueberry, Apple, Mangosteen, Bilberry, Chokeberry, and Goji Berry. It is high in fruit polyphenols, flavonoids, anthocyanins, catechins, proanthocyanins, ellagic acid, xanthines, chlorogenic acid, pterostilbenes, resveratrol, phloridzin, quercetin, zeaxanthin, carotinoids, polysaccharides, quinic acid, and more. With its diverse blend, SFB® offers over 40-50% polyphenols as well as >9,000 ORAC units in a single gram.

Polyphenols, anthocyanins, and other plant elements are powerful ingredients associated with a variety of areas of human health, including healthy aging, healthy glucose metabolism, cardiovascular health, and inflammation management.

HEALTH BENEFITS OF GOJI BERRY

The Goji Berry extract in Ultimate Protector+ is non-GMO and has been extracted with  water. Testing has indicated the product contains over 1.5% polyphenols. In numerous epidemiological studies, goji berries have been associated with a decreased risk of chronic diseases such as cardiovascular disease, cancer, and asthma.

CHEMICAL COMPOSITION OF GOJI BERRIES

Goji Berries contain abundant polysaccharides (LBPs, comprising 5%–8% of the dried fruits), scopoletin (6-methoxy-7-hydroxycoumarin, also named chrysatropic acid, ecopoletin, gelseminic acid, and scopoletol), the glucosylated precursor, and stable vitamin C analog 2-O-β-D-glucopyranosyl-L-ascorbic acid, carotenoids (zeaxanthin and β-carotene), betaine, cerebroside, β-sitosterol, flavonoids, amino acids, minerals, and vitamins (in particular, riboflavin, thiamin, and ascorbic acid).

The predominant carotenoid is zeaxanthin, which exists mainly as dipalmitate (also called physalien or physalin). The content of vitamin C (up to 42 mg/100 g) in goji berry (also known as wolfberry) is comparable to that of fresh lemon fruits. As to the seeds, they contain zeaxanthin (83%), β-cryptoxanthin (7%), β-carotene (0.9%), and mutatoxanthin (1.4%), as well as some minor carotenoids.

In fact, increasing lines of experimental studies have revealed that L. barbarum berries have a wide array of pharmacological activities, which is thought to be mainly due to its high LBPs content. Water-soluble LBPs are obtained using an extraction process that removes the lipid soluble components such as zeaxanthin and other carotenoids with alcohol. LBPs are estimated to comprise 5%–8% of LBFs and have a molecular weight ranging from 24 kDa to 241 kDa. LBPs consist of a complex mixture of highly branched and only partly characterized polysaccharides and proteoglycans.

The glycosidic part accounts, in most cases, for about 90%–95% of the mass and consists of arabinose, glucose, galactose, mannose, rhamnose, xylose, and galacturonic acid. LBPs are considered the most important functional constituents in LBFs. Different fractions of LBPs have different activities and the galacturonic acid content is an imperative factor for activities of LBP. The bioactivities of polysaccharides are often in reverse proportion with their molecular weights. Increasing lines of evidence from both preclinical and clinical studies support the medicinal, therapeutic, and health-promoting effects of LBPs.

Scientific Studies on the Antioxidant Effects of GOJI BERRIES

Databases of scientific studies (like the National Institutes of Health (NIH) PubMed database) contain numerous of up-to-date studies and abstracts about goji berries.

Below we provide a few relevant scientific studies on the health benefits of goji berries.

Goji Berries as a Potential Natural Antioxidant Medicine: An Insight into Their Molecular Mechanisms of Action.

Oxid Med Cell Longev. 2019 Jan 9;2019:2437397. doi: 10.1155/2019/2437397. eCollection 2019.
Authors: Ma ZF, Zhang H, Teh SS, Wang CW, Zhang Y, Hayford F, Wang L, Ma T, Dong Z, Zhang Y, Zhu Y1
From: https://www.ncbi.nlm.nih.gov/pubmed/30728882

Abstract

Goji berries (Lycium fruits) are usually found in Asia, particularly in northwest regions of China. Traditionally, dried goji berries are cooked before they are consumed. They are commonly used in Chinese soups and as herbal tea. Moreover, goji berries are used for the production of tincture, wine, and juice. Goji berries are high antioxidant potential fruits which alleviate oxidative stress to confer many health protective benefits such as preventing free radicals from damaging DNA, lipids, and proteins. Therefore, the aim of the review was to focus on the bioactive compounds and pharmacological properties of goji berries including their molecular mechanisms of action. The health benefits of goji berries include enhancing hemopoiesis, antiradiation, antiaging, anticancer, improvement of immunity, and antioxidation. There is a better protection through synergistic and additive effects in fruits and herbal products from a complex mixture of phytochemicals when compared to one single phytochemical.

An evidence-based update on the pharmacological activities and possible molecular targets of Lycium barbarum polysaccharides

Drug Des Devel Ther. 2015; 9: 33–78.
Authors: Jiang Cheng, Zhi-Wei Zhou, Hui-Ping Sheng, Lan-Jie He, Xue-Wen Fan, Zhi-Xu He, Tao Sun, Xueji Zhang, Ruan Jin Zhao, Ling Gu, Chuanhai Cao,  and Shu-Feng Zhou
From: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4277126/

Abstract

Lycium barbarum berries, also named wolfberry, Fructus lycii, and Goji berries, have been used in China and other Asian countries for more than 2,000 years as a traditional medicinal herb and food supplement. L. barbarum polysaccharides (LBPs) are the primary active components of L. barbarum berries and have been reported to possess a wide array of pharmacological activities. Herein, we update our knowledge on the main pharmacological activities and possible molecular targets of LBPs. Several clinical studies in healthy subjects show that consumption of wolfberry juice improves general wellbeing and immune functions. LBPs are reported to have antioxidative and antiaging properties in different models. LBPs show antitumor activities against various types of cancer cells and inhibit tumor growth in nude mice through induction of apoptosis and cell cycle arrest. LBPs may potentiate the efficacy of lymphokine activated killer/interleukin-2 combination therapy in cancer patients. LBPs exhibit significant hypoglycemic effects and insulin-sensitizing activity by increasing glucose metabolism and insulin secretion and promoting pancreatic β-cell proliferation. They protect retinal ganglion cells in experimental models of glaucoma. LBPs protect the liver from injuries due to exposure to toxic chemicals or other insults. They also show potent immunoenhancing activities in vitro and in vivo. Furthermore, LBPs protect against neuronal injury and loss induced by β-amyloid peptide, glutamate excitotoxicity, ischemic/reperfusion, and other neurotoxic insults. LBPs ameliorate the symptoms of mice with Alzheimer’s disease and enhance neurogenesis in the hippocampus and subventricular zone, improving learning and memory abilities. They reduce irradiation- or chemotherapy-induced organ toxicities. LBPs are beneficial to male reproduction by increasing the quality, quantity, and motility of sperm, improving sexual performance, and protecting the testis against toxic insults. Moreover, LBPs exhibit hypolipidemic, cardioprotective, antiviral, and antiinflammatory activities. There is increasing evidence from preclinical and clinical studies supporting the therapeutic and health-promoting effects of LBPs, but further mechanistic and clinical studies are warranted to establish the dose–response relationships and safety profiles of LBPs.

Biological activities and potential health benefit effects of polysaccharides isolated from Lycium barbarum L.

2013 Mar;54:16-23. doi: 10.1016/j.ijbiomac.2012.11.023. Epub 2012 Nov 28.
Jin M1, Huang Q, Zhao K, Shang P.
From: https://www.ncbi.nlm.nih.gov/pubmed/23200976

Abstract

Recently, isolation and investigation of novel ingredients with biological activities and health benefit effects from natural resources have attracted a great deal of attention. The fruit of Lycium barbarum L., a well-known Chinese herbal medicine as well as valuable nourishing tonic, has been used historically as antipyretic, anti-inflammation and anti-senile agent for thousands of years. Modern pharmacological experiments have proved that polysaccharide is one of the major ingredients responsible for those biological activities in L. barbarum. It has been demonstrated that L. barbarum polysaccharides had various important biological activities, such as antioxidant, immunomodulation, antitumor, neuroprotection, radioprotection, anti-diabetes, hepatoprotection, anti-osteoporosis and antifatigue. The purpose of the present review is to summarize previous and current references regarding biological activities as well as potential health benefits of L. barbarum polysaccharides.

Goji (Lycium barbarum and L. chinense): Phytochemistry, Pharmacology and Safety in the Perspective of Traditional Uses and Recent Popularity

Planta Med 2010; 76(1): 7-19
Author: Olivier Potterat
From: https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0029-1186218#AT0541-1

Abstract

Since the beginning of this century, Goji berries and juice are being sold as health food products in western countries and praised in advertisements and in the media for well-being and as an anti-aging remedy. The popularity of Goji products has rapidly grown over the last years thanks to efficient marketing strategies. Goji is a relatively new name given to Lycium barbarum and L. chinense, two close species with a long tradition of use as medicinal and food plants in East Asia, in particular in China. While only L. barbarum is officinal, the fruit (fructus Lycii) and the root bark (cortex Lycii radicis) of both species are used in the folk medicine. We review here the constituents, pharmacology, safety, and uses of L. barbarum and L. chinensewith consideration to the different parts of the plant. Investigations of the fruit have focused on proteoglycans, known as “Lycium barbarum polysaccharides”, which showed antioxidative properties and some interesting pharmacological activities in the context of age related diseases such as atherosclerosis and diabetes. As to the root bark, several compounds have demonstrated a hepatoprotective action as well as inhibitory effects on the rennin/angiotensin system which may support the traditional use for the treatment of hypertension. While there are no signs of toxicity of this plant, two cases of possible interaction with warfarin point to a potential risk of drug interaction. In view of the available pharmacological data and the long tradition of use in the traditional Chinese medicine, L. barbarum and L. chinense certainly deserve further investigation. However, clinical evidences and rigorous procedures for quality control are indispensable before any recommendation of use can be made for Goji products.

GOJI BERRIES SUMMARY

Goji Berries are an important fruit full of polyphenols, antioxidants, polysaccharides (LBPs), carotenoids, and Nrf2 activators that help to make Ultimate Protector+ such an outstanding nutritional supplement.

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ULTIMATE PROTECTOR+ INGREDIENTS – APPLE

Dr. Hank Liers, PhD biography about us HPDI integratedhealth formulator founder CEO scientist physicist wild bilberry and wild blueberry Ultimate Protector+ includes apple extract, as well as extracts from 12 different fruits, vegetables, and herbs. Each of these ingredients contain substances considered to be polyphenols, antioxidants, and Nrf2 activators. In this article, I explore the ingredient apple (Malus pumila mill.) extract, which is a component of SFB® – Standardized Fruit Blend from Ethical Naturals, Inc.

apple extract

Ultimate Protector+ Includes Apple

SFB® is a proprietary formula that combines extracts from Grape, Cranberry, Pomegranate, Blueberry, Apple, Mangosteen, Bilberry, Chokeberry, and Goji Berry. It is high in fruit polyphenols, flavonoids, anthocyanins, catechins, proanthocyanins, ellagic acid, xanthines, chlorogenic acid, pterostilbenes, resveratrol, phloridzin, quercetin, zeaxanthin, and quinic acid. With its diverse blend, SFB® offers over 40-50% polyphenols as well as >9,000 ORAC units in a single gram.

Polyphenols, anthocyanins and other plant elements are powerful ingredients associated with a variety of areas of human health, including healthy aging, healthy glucose metabolism, cardiovascular health, and inflammation management.

HEALTH BENEFITS OF APPLE

The Apple extract in Ultimate Protector+ has been extracted with non-GMO food grade ethanol and distilled water. Testing has indicated the product contains over 40% polyphenols. In numerous epidemiological studies, apples have been associated with a decreased risk of chronic diseases such as cardiovascular disease, cancer, and asthma.

When compared to many other commonly consumed fruits in the United States, apples had the second highest level of antioxidant activity. Apples also ranked the second for total concentration of phenolic compounds, and perhaps more importantly, apples had the highest portion of free phenolics when compared to other fruits.

APPLE PHYTOCHEMICALS

Apples contain a large concentration of flavonoids, as well as a variety of other phytochemicals, and the concentration of these phytochemicals may depend on many factors, such as cultivar of the apple, harvest and storage of the apples, and processing of the apples. The concentration of phytochemicals also varies greatly between the apple peels and the apple flesh.

Some of the most well studied antioxidant compounds in apples include quercetin-3-galactoside, quercetin-3-glucoside, quercetin-3-rhamnoside, catechin, epicatechin, procyanidin, cyanidin-3-galactoside, coumaric acid, chlorogenic acid, gallic acid, and phloridzin. Recently researchers have examined the average concentrations of the major phenolic compounds in six cultivars of apples. They found that the average phenolic concentrations among the six cultivars were: quercetin glycosides, 13.2 mg/100 g fruit; vitamin C, 12.8 mg/100 g fruit; procyanidin B, 9.35 mg/100 g fruit; chlorogenic acid, 9.02 mg/100 g fruit; epicatechin, 8.65 mg/100 g fruit; and phloretin glycosides, 5.59 mg/100 g fruit.

The compounds most commonly found in apple peels consist of the procyanidins, catechin, epicatechin, chlorogenic acid, phloridzin, and the quercetin conjugates. In the apple flesh, there is some catechin, procyanidin, epicatechin, and phloridzin, but these compounds are found in much lower concentrations than in the peels. Quercetin conjugates are found exclusively in the peel of the apples. Chlorogenic acid tends to be higher in the flesh than in the peel.

Because the apple peels contain more antioxidant compounds, especially quercetin, apple peels may have higher antioxidant activity and higher bioactivity than the apple flesh. Research showed that apples without the peels had less antioxidant activity than apples with the peels. Apples with the peels were also better able to inhibit cancer cell proliferation when compared to apples without the peels. More recent work has shown that apple peels contain anywhere from two to six times (depending on the variety) more phenolic compounds than in the flesh, and two to three times more flavonoids in the peels when compared to the flesh. The antioxidant activity of these peels was also much greater, ranging from two to six times greater in the peels when compared to the flesh, depending on the variety of the apple. This work is supported a study which found that rats consuming apple peels showed greater inhibition of lipid peroxidation and greater plasma antioxidant capacity when compared to rats fed apple flesh.

Many of these phytochemicals from apples have been widely studied, and many potential health benefits have been attributed to these specific phytochemicals. The procyanidins, epicatechin and catechin, have strong antioxidant activity and have been found to inhibit low density lipoprotein (LDL) oxidation in vitro. In mice, catechin inhibits intestinal tumor formation and delays tumors onset. One  study found that chlorogenic acid has very high alkyl peroxyl radical (ROO•) scavenging activity. Compared to about 18 other antioxidant compounds (including quercetin, gallic acid, α-tocopherol), chlorogenic was second only to rutin. Since ROO• may enhance tumor promotion and carcinogenesis, chlorogenic acid may add to the protective effect of apples against cancer. Chlorogenic acid has been found to inhibit 8-dehydroxy-deoxyguanosine formation in cellular DNA in a rat model following treatment with 4-nitroquinoline-1-oxide.

Quercetin is also a strong antioxidant, and is thought to have potential protective effects against both cancer and heart disease. Briefly, quercetin has been found to down regulate expression of mutant p53 in breast cancer cells, arrest human leukemic T-cells in G1, inhibit tyrosine kinase, and inhibit heat shock proteins. Quercetin has protected Caco-2 cells from lipid peroxidation induced by hydrogen peroxide and Fe2+. In mice liver treated with ethanol, quercetin decreased lipid oxidation and increased glutathione, protecting the liver from oxidative damage. Recently, it has been found that high doses of quercetin inhibit cell proliferation in colon carcinoma cell lines and in mammary adenocarcinoma cell lines, but at low doses quercetin increased cell proliferation (20% in colon cancer cells and 100% in breast cancer cells). However, low doses of quercetin (10 uM) inhibited cell proliferation in Mol-4 Human Leukemia cells and also induced apoptosis. Quercetin inhibited intestinal tumor growth in mice, but not in rats. Low levels of quercetin inhibited platelet aggregation, calcium mobilization, and tyrosine protein phosphorylation in platelets. Modulation of platelet activity may help prevent cardiovascular disease.

SCIENTIFIC STUDIES ON THE ANTIOXIDANT EFFECTS OF APPLE

Below, I provide relevant scientific studies on the antioxidant effects and potential health benefits of apple.

Apple phytochemicals and their health benefits

Jeanelle Boyer1 and Rui Hai Liu1

Abstract

Evidence suggests that a diet high in fruits and vegetables may decrease the risk of chronic diseases, such as cardiovascular disease and cancer, and phytochemicals including phenolics, flavonoids and carotenoids from fruits and vegetables may play a key role in reducing chronic disease risk. Apples are a widely consumed, rich source of phytochemicals, and epidemiological studies have linked the consumption of apples with reduced risk of some cancers, cardiovascular disease, asthma, and diabetes. In the laboratory, apples have been found to have very strong antioxidant activity, inhibit cancer cell proliferation, decrease lipid oxidation, and lower cholesterol. Apples contain a variety of phytochemicals, including quercetin, catechin, phloridzin and chlorogenic acid, all of which are strong antioxidants. The phytochemical composition of apples varies greatly between different varieties of apples, and there are also small changes in phytochemicals during the maturation and ripening of the fruit. Storage has little to no effect on apple phytochemicals, but processing can greatly affect apple phytochemicals. While extensive research exists, a literature review of the health benefits of apples and their phytochemicals has not been compiled to summarize this work. The purpose of this paper is to review the most recent literature regarding the health benefits of apples and their phytochemicals, phytochemical bioavailability and antioxidant behavior, and the effects of variety, ripening, storage and processing on apple phytochemicals..

Cancer chemopreventive potential of apples, apple juice, and apple components.

 Gerhauser C1.

From: https://www.ncbi.nlm.nih.gov/pubmed/18855307

Abstract

Apples ( MALUS sp., Rosaceae) are a rich source of nutrient as well as non-nutrient components and contain high levels of polyphenols and other phytochemicals. Main structural classes of apple constituents include hydroxycinnamic acids, dihydrochalcones, flavonols (quercetin glycosides), catechins and oligomeric procyanidins, as well as triterpenoids in apple peel and anthocyanins in red apples. Several lines of evidence suggest that apples and apple products possess a wide range of biological activities which may contribute to health beneficial effects against cardiovascular disease, asthma and pulmonary dysfunction, diabetes, obesity, and cancer (reviewed by Boyer and Liu, Nutr J 2004). The present review will summarize the current knowledge on potential cancer preventive effects of apples, apple juice and apple extracts (jointly designated as apple products). In brief, apple extracts and components, especially oligomeric procyanidins, have been shown to influence multiple mechanisms relevant for cancer prevention in IN VITRO studies. These include antimutagenic activity, modulation of carcinogen metabolism, antioxidant activity, anti-inflammatory mechanisms, modulation of signal transduction pathways, antiproliferative and apoptosis-inducing activity, as well as novel mechanisms on epigenetic events and innate immunity. Apple products have been shown to prevent skin, mammary and colon carcinogenesis in animal models. Epidemiological observations indicate that regular consumption of one or more apples a day may reduce the risk for lung and colon cancer.

Apple Peel Polyphenols and Their Beneficial Actions on Oxidative Stress and Inflammation

. 2013; 8(1): e53725.
Marie Claude Denis, Alexandra Furtos, Stéphanie Dudonné, Alain Montoudis, Carole Garofalo, Yves Desjardins, Edgard Delvin, and Emile Levy
From: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3553108/#

Abstract

Since gastrointestinal mucosa is constantly exposed to reactive oxygen species from various sources, the presence of antioxidants may contribute to the body’s natural defenses against inflammatory diseases.

Hypothesis

To define the polyphenols extracted from dried apple peels (DAPP) and determine their antioxidant and anti-inflammatory potential in the intestine. Caco-2/15 cells were used to study the role of DAPP preventive actions against oxidative stress (OxS) and inflammation induced by iron-ascorbate (Fe/Asc) and lipopolysaccharide (LPS), respectively.

Results

The combination of HPLC with fluorescence detection, HPLC-ESI-MS TOF and UPLC-ESI-MS/MS QQQ allowed us to characterize the phenolic compounds present in the DAPP (phenolic acids, flavonol glycosides, flavan-3-ols, procyanidins). The addition of Fe/Asc to Caco-2/15 cells induced OxS as demonstrated by the rise in malondialdehyde, depletion of n-3 polyunsaturated fatty acids, and alterations in the activity of endogenous antioxidants (SOD, GPx, G-Red). However, preincubation with DAPP prevented Fe/Asc-mediated lipid peroxidation and counteracted LPS-mediated inflammation as evidenced by the down-regulation of cytokines (TNF-α and IL-6), and prostaglandin E2. The mechanisms of action triggered by DAPP induced also a down-regulation of cyclooxygenase-2 and nuclear factor-κB, respectively. These actions were accompanied by the induction of Nrf2 (orchestrating cellular antioxidant defenses and maintaining redox homeostasis), and PGC-1α (the “master controller” of mitochondrial biogenesis).

Conclusion

Our findings provide evidence of the capacity of DAPP to reduce OxS and inflammation, two pivotal processes involved in inflammatory bowel diseases.

APPLE SUMMARY

Apple is an important fruit full of polyphenols, anthocyanins, antioxidants, and Nrf2 activators that help to make Ultimate Protector+ such an outstanding nutritional supplement.

MULTIVITAMINS – WHY YOU NEED THEM

Fred Liers PhD multivitaminsMultivitamins are the most important of the basic or foundational supplements providing nutrients essential for health and wellness. Because if there is a single nutritional supplement everyone should take, a multivitamin is it.

But it can’t be just any multivitamin. The best multivitamins are complete, high-potency, high-quality, high-purity, provide a complete range of essential vitamins and minerals, and contain advanced forms—more about advanced forms later.

The purpose of taking a high-potency multivitamin not only is to provide the body with amounts and forms of nutrients meeting minimum requirements for avoiding deficiency conditions, but also sufficient levels of nutrients that can support optimal health. Because vitamins levels for optimal health are NOT the same as levels required to avoid deficiency conditions.

MORE THAN DAILY ALLOWANCES

While 40% of Americans say they take a multivitamin daily, how many actually obtain all the nutrients they need for optimal health from taking it? Practically no one. Why?

Because basic “recommended daily amounts” (100% of daily allowance) typically found in multivitamins are based on models for disease prevention. That is, these are minimum levels indicated to avoid conditions like Pellagra (caused by vitamin B3 deficiency), Beriberi (caused by vitamin B1 deficiency), or Rickets (caused by vitamin D deficiency), for example. Nutrient fortification of foods by law has mostly eradicated those conditions. But, as noted, minimum recommended amounts are not the amounts required for optimal health.

The best multivitamin supplements therefore do not provide just 100% of a recommended daily amount of a certain nutrient, but far higher amounts. That is for truly optimal health, high-potency is a must in multivitamins. One of the main reasons for this is “biochemical individuality.” While most people fall within a certain range in terms of their needs for a specific nutrient, the overall range (or bell curve) may be quite large. Your needs may be greater.

Another, related reason is genetics. If you are heterozygous for a gene that requires a specific nutrient, then you may already be at a disadvantage for assimilating or processing it. If you are homozygous, then not having sufficient amounts of a nutrient can have much larger, adverse consequences.

For any given nutrient, then, your needs may be higher or significantly higher than other people’s needs. The best way to guarantee your needs are met is to ensure you consume larger amounts. That is, a high-potency multivitamin providing levels of nutrients well above the minimum amounts established to avoid deficiency.

MULTIVITAMINS ARE SAFE, LOW COST,
AND EFFECTIVE

High-potency multivitamins work well because vitamins—at least at the levels we are talking about here—are non-toxic, safe, and well-tolerated. Add to the safety of vitamins their relatively low cost (especially compared to pharmaceuticals) that solidifies the case for high-potency multivitamins as a virtual “no-brainer” for supporting good health.

That is the basic rationale for why you need a high-quality, high-potency multivitamin. There are many other reasons. Such reasons include the fact that diet alone is usually not enough to provide the levels of basic nutrients you need.

DIET ALONE IS USUALLY INSUFFICIENT FOR OPTIMAL LEVELS OF NUTRIENTS

Diet alone could perhaps be sufficient if foods were nutrient-dense and you consumed enough of them. But foods today are typically not nutrient-dense given how modern agriculture has stripped the soils of essential nutrients. Herbicides and pesticides then poison foods. And the widely used glyphosate herbicide (RoundUp) actually depletes nutrients in foods by blocking their uptake in plants leading to further depletion in crop foods. Food processing then strips out additional nutrients. Get the picture?

On top of all this, your requirements for nutrients are increased by factors such as pollution and chemical exposures (and greater stress on detoxification organs), emotional stress, immune stresses (like fighting off colds or flu), and even free-radical stress caused by electromagnetic fields (EMFs) such as mobile phone and Wi-Fi exposures. In many cases, various stresses and environmental exposures put a greater burden on your antioxidant defense systems by subjecting you to free-radical attack. This is just the beginning.

Assuming your diet were “perfect” (which most likely it is not), your needs for various nutrients will vary depending on your levels of exposure to stresses (emotional, chemical, electromagnetic, etc.). This means that as your needs for extra nutrients rise to combat these stresses, the simplest and best way to meet those needs is through consuming additional, supplemental amounts of nutrients—to successfully meet those needs. Otherwise, having only minimal amounts (i.e., daily values created to avoid deficiency diseases) means your need for higher amounts will not be met.

IF YOU DO NOTHING ELSE, TAKE A HIGH-QUALITY MULTIVITAMIN

A multivitamin can meet those additional needs, or at least start meeting them. In fact, a multivitamin is the best “first line of defense.” In the HPDI system, a multivitamin is just one of six foundational supplements—but it “first among equals” and therefore the very first supplement we recommend. This means that if you do nothing else, then take a multivitamin.

Need another good reason to make a multivitamin? Again, genetics. HPDI has teamed up with Bodysync, the developer of Nutrisync genetic tests (available to HPDI resellers on the reseller website and to retail customers by phone) that offers testing for health-related genetic variations in your DNA.

Among the first things we realized after analyzing Nutrsync genetic test results is that many genetic variants that may cause problems with uptake of certain nutrients—or that require additional amounts of nutrients—can be partly or wholly mitigated by taking a high-potency multivitamin. This is not true in every case, but surprisingly the nutrients provided in a quality multivitamin can be a strong defense in this regard.

Another thing we noticed is that the results of almost everyone taking the Nutrisync test exhibit certain genetic weaknesses that would benefit from a multivitamin. Another “no brainer” observation that may not have been so obvious beforehand, yet which corresponds with what we have been recommending to clients for decades: Take a multivitamin!

People may not realize that optimal health is within reach. Taking a high-potency multivitamin daily is a major first step toward achieving it.

BENEFITS OF A HIGH-QUALITY, HIGH-POTENCY MULTIVITAMIN

Considering all the factors involved in optimal nutrition—and how important nutrition is to health—it is remarkable to think that your health can be well maintained or dramatically improved simply by taking a high-potency multivitamin. Yet, that is a fact. And

• Ensures complete nutrition by providing a wide-range of nutrients to supplement those obtainable by diet
• Provides optimal levels of nutrients in a balanced way
• Guards against deficiencies of particular nutrients
• Protects against nutrient depletion caused by increased needs for nutrients (e.g., various stresses or periods of inadequate intake).
• Helps you fulfill genetic potential by supplying nutrients required for optimal genetic expression and for overcoming adverse genetic factors
• Safe, low cost, and effective means to support good health

BENEFITS OF HPDI MULTIVITAMINS

HPDI formulates and sells some of the highest-quality, high-potency multivitamins available. Many of our customers are health professionals who supply their clients with our multivitamins—because health professionals demand supplements proven to be effective. And they know the difference!

• HPDI multivitamins provide a complete range of nutrients, including vitamins, minerals, cofactors, and phytonutrients
• Therapeutic levels of nutrients in amounts necessary for health—typically greater than daily values
• Nutrients balanced so as not to provide too little or too much of any given nutrient
• High-purity with minimal excipients, and avoidance of harmful excipients
• Advanced forms (including coenzyme vitamins) for optimal uptake, transport, and utilization
• Inclusion of coenzyme form B vitamins
• Inclusion of potent antioxidants and Nrf2 activators
• Formulated by Hank Liers, PhD, designer of supplements for 30 years
• Vegetarian capsules

HPDI MULTIVITAMINS

Health Products Distributors, Inc. (HPDI) currently offers five multivitamins, including Mighty Multi-Vite!, Multi Two (tabs and caps), Mini Multi, and Chewable Kids Mighty-Multi. Each multivitamin is formulated for a specific purpose:

Multi Two and Mighty Multi-Vite! are flagship multivitamins with advanced forms. Multi Two offers higher levels of B vitamins, whereas Mighty Multi-Vite! provides relatively more antioxidants and phytonutrients.

Mini Multi is formulated for chemically and environmentally sensitive individuals or those who seek ultra-high purity. Mini Multi contains no excipients (i.e., additives or fillers), and provides 100% coenzyme vitamins.

Chewable Kids Mighty-Multi! tastes great and includes xylitol to prevent cavities. Kids love this chewable formula, but it is also scalable for adults. This formula is most similar to Mighty Multi-Vite! in terms its nutrient content.

HPDI multivitamins

HPDI multivitamins: Multi Two (caps and tabs), Mighty Multi-Vite!, Mini Multi, and Chewable Kids Mighty-Multi.

HPDI MULTIVITAMINS IN DEPTH

1. MIGHTY MULTI-VITE!

HANK & BRIAN’S™ MIGHTY MULTI-VITE! (or as we often call it, the “Mighty Multi”) is perhaps the premier HPDI multivitamin, and definitely among the flagship multivitamins we offer. I personally take this one most of the time. It is in the “Hank & Brian’s” line, which generally are among our best products.

Mighty Multi incorporates the latest nutritional research in a complete formula that combines the highest-quality, most assimilable forms of vitamins and minerals along with advanced herbal nutrition.

Mighty Multi-Vite! is an advanced, cutting-edge multivitamin that is a leader within HPDI’s line of foundational supplements. This formula exhibits superior performance with respect to supporting optimal health, and is among the world’s most sophisticated multivitamins. Mighty Multi-Vite! works synergistically with other foundational supplements to help sustain maximum health, vitality, and promote longevity.

Now with these 7 absolutely essential improvements:

  • Now in an ultra-pure vegetarian capsule
  • Vitamin B12 is now in the methylcobalamin coenzyme form
  • Turmeric is now in an extract form with 95% curcuminoids – a powerful Nrf2 activator
  • Now uses broccoli sprouts powder containing sulforaphane – another powerful Nrf2 activator
  • Contains both Vitamin K1 and Vitamin K2 (as MK-7)
  • Contains the best coenzyme form of folate – L-5-MTHF
  • Contains no magnesium stearate
Mighty Multi multivitamins

Mighty Multi-Vite! is an HPDI flagship multivitamin offering special nutrients for antioxidant protection.

MIGHTY MULTI-VITE! BENEFITS

COMPLETE, BALANCED ESSENTIAL NUTRITION – Provides a full spectrum of nutrients exceptionally well balanced for creating and maintaining optimal health. Mighty Multi-Vite! offers all the most important vitamins along with minerals, cofactors, antioxidants, and herbs.

RAPID, EASY ASSIMILATION – Incorporates the most bioavailable vitamin and mineral carriers most easily recognized and rapidly assimilated by your body. In addition, the formula uses multiple forms of mineral carriers to ensure assimilation. In addition, the capsule form speeds uptake because it does not require time for the body to break it down (unlike tablets).

ENERGIZING – Includes coenzyme form vitamins and Krebs Cycle bionutrients that work with your body to create super high energy levels. Provides significant levels of B vitamins (especially coenzyme B vitamins) known for boosting energy, supporting the body during times of stress, nerve function, heart function, and for working together with dietary RNA (found in Rejuvenate!™ superfoods) to produce significant therapeutic effects.

FOUNDATIONAL SUPPLEMENT – For creating health and establishing a complete supplement program. Providing excellent foundational nutrition, Mighty Multi-Vite! is designed to work synergistically with other foundational formulas for maximum health benefits.

In addition to the newest improvements, Mighty Multi-Vite! features:

  • A full spectrum of B-complex vitamins, most in coenzyme forms, as well as more conventional forms. Includes Vitamin B1 as thiamin HCl and thiamin diphosphate, Vitamin B2 as riboflavin and riboflavin-5′-phosphate, Vitamin B3 as niacinamide and niacin, Vitamin B5 as pantothenic acid, Vitamin B6 as pyridoxine HCl and pyridoxal-5′-phosphate, folate as L-5-methyltetrahydrofolate (L-5-MTHF), Vitamin B12 as methylcobalamin, and biotin.
  • All of the most absorbable and usable forms of the fat-soluble vitamin group, including Vitamin A (as beta-carotene), Vitamin E (as d-alpha tocopherol succinate), Vitamin D-3 (as cholecalciferol), Vitamin K (as phytonadione and MK-7).
  • A complete and balanced supply of the most abundant carotenoids found in the body, including beta- and alpha-carotene, as well as lycopene and lutein.
  • A variety of the best-known herbal preparations, including quercetin, grape extract, turmeric (95% curcuminoids), broccoli sprouts powder, octacosanol from policosanol, and stevia.
  • All of the known essential minerals in forms readily absorbed and recognized by the body including calcium, magnesium, potassium, zinc, manganese, boron, copper, chromium, molybdenum, vanadium, and selenium.
  • Mineral carriers such as ascorbates, Krebs cycle bionutrients and amino acids providing the body with important metabolic substrates and vitamins, including citrate, succinate, alpha-ketoglutarate, fumarate, malate, glycinate, aspartate, sebacate, and Vitamin C.
  • Includes the important sulfur-containing amino acid N-Acetyl-L-Cysteine to support the body’s antioxidant and detoxification systems and betaine HCl to support digestive processes.
  • Includes choline and inositol which play a crucial role in all of the cell membranes of the body, in brain function, and in liver function.
  • Exclusion of the prooxidant minerals of iron and iodine which can lead to excessive free-radical production and PABA that sometimes adversely affects brain function in some individuals. Note: we sell iodine as separate formulas.
  • Capsule form that ensures the maximum absorption of ingredients.
  • Four-per-day full dosage that allows for partial dosing for children, seniors, and pets.
  • Vegetarian formula – including capsule.
  • Capsule contents designed to smell and taste good to adults and children when emptied into smoothies, drinks, and foods. This allows greater flexibility of use.
  • Exclusion of ingredients such as wheat, gluten, dairy, corn, soy, and egg having well-known antigenic properties and that may be associated with allergy or delayed hypersensitivity reactions.
  • A minimum of excipients, fillers, lubricants, etc. having deleterious effects in some individuals. No GMOs.

As I mentioned previously, the Mighty Multi is uniquely advanced it that it provides special antioxidant ingredients like turmeric, grape extract, and broccoli sprouts powder.

2 & 3. MULTI TWO (CAPS & TABS)

MULTI TWO is another HPDI flagship multivitamin. We recommend it especially for individuals who prefer more B vitamins built into their multivitamin. Yet, it offers somewhat fewer antioxidant nutrients.

MULTI TWO is a pure, complete, biochemically formulated multivitamin supplement with minerals and cofactors. It dissolves readily and is highly bioavailable. All ingredients are sourced for purity and carefully selected to avoid common food allergens. MULTI TWO is available in tablet and vegetarian capsule forms.

MULTI TWO is among HPDI’s most popular multivitamins, providing top-notch quality, high-purity, advanced design and formulation, and exceptional value for the price.

The formula comes in tablet or capsule forms. The tablet is suitable for vegetarians, only containing plant fiber to bind components, further eliminating chemical contaminants. The capsule form now is also vegetarian. The capsules have a four-per-day full dosage allowing for partial dosing for children, seniors, and pets. Note: the capsule’s powder contents taste quite good to most people, so it can be added to sippy cups, blender drinks, smoothies, pet foods, etc.

MULTI TWO is one of HPDI’s foundational multivitamin supplements in our health recovery and maintenance programs. A foundational program of supplements includes a multivitamin, essential fatty acids, a Vitamin C formula, and a Rejuvenate!™ superfood.

multivitamins

Multi Two Caps are among HPDI’s premier therapeutic-grade multivitamin formulas providing a complete range of nutrients.

MULTI TWO OFFERS UNIQUE BENEFITS

  • COMPLETE, BALANCED FOUNDATIONAL NUTRITION. Full-Spectrum of Nutrients Exceptionally Balanced for Supporting Your Health. Foundational Formula Ideal for Providing Essential Foundational Nutrition. A high-quality multivitamin is the foundation (i.e., core) for a complete nutritional supplement program.
  • RAPID AND EFFECTIVE ASSIMILATION. Incorporates Bioavailable Vitamin and Mineral Carriers Your Body Recognizes and Can Assimilate Immediately. Plus, Multiple Carriers Ensure Assimilation. Tablet or Capsule Forms Rapidly Assimilated.
  • POWERFULLY ENERGIZING. Includes Coenzyme Form Vitamins and Krebs Cycle Bionutrients that work with your body to create high energy levels. Full-Spectrum Essential Nutrients Needed For Building, Supporting, and Maintaining Excellent Health.
  • HIGH PURITY. One of the Purest Available Supplements. Carefully Designed To Exclude Common Allergens, and Exclude or Minimize Excipients, Additives, and Fillers.
  • TABLET AND VEGETARIAN CAPSULE FORMS. We Offer Both Forms Giving You More Choice. Take Your Pick.
  • FOUNDATIONAL SUPPLEMENT. Providing solid foundational nutrition, MULTI TWO functions most effectively when used in conjunction with other foundational formulas, especially Vitamin C formulas (including ULTIMATE PROTECTOR™ and PRO-C™), Essential Fatty Acid formulas (including Omega Plus and Essential Fats Plus E), and REJUVENATE!™ superfoods. These foundational supplements together form the foundation of a complete nutritional supplement program. From here, you can add additional supplements (enhancements and specific condition formulas) addressing your individual needs, i.e., by pinpointing where your body requires additional nutritional support.

MULTI TWO FEATURES

  • A full-spectrum of B-complex vitamins, most in coenzyme forms, as well as more conventional forms. Includes Vitamin B1 as thiamin HCl and thiamin diphosphate, Vitamin B2 as riboflavin and riboflavin 5’-phosphate, Vitamin B3 as niacinamide and niacin, and Vitamin B6 as pyridoxine HCl and pyridoxal 5’-phosphate, folate from calcium folinate and 5-MTHF, Vitamin B12 as methylcobalamin and hydroxocobalamin, and biotin.
  • All of the most absorbable and usable forms of the fat-soluble vitamin group, including Vitamin A (as natural beta-carotene), Vitamin E (as d-alpha tocopherol succinate and mixed tocopherols), Vitamin D3 (as cholecalciferol), and two forms of Vitamin K (K1 as phylloquinone and K2 as menaquinone-7).
  • Effective herbal preparations, including quercetin, grape extract, octacosanol.
  • All of the known essential minerals in forms readily absorbed and recognized by the body including calcium, magnesium, potassium, zinc, manganese, boron, copper, chromium, molybdenum, vanadium, and selenium.
  • Mineral carriers such as ascorbates, Krebs cycle bionutrients, and amino acids providing the body with important metabolic substrates and vitamins, including citrate, succinate, alpha-ketoglutarate, fumarate, malate, glycinate, aspartate, sebacate, and Vitamin C.
  • Includes betaine HCl to support digestive processes.
  • Choline and inositol which play a crucial role in all of the cell membranes of the body, in brain function, and in liver function.
  • Exclusion of the prooxidant minerals of iron and iodine which can lead to excessive free-radical production and PABA that sometimes adversely affects brain function in some individuals.
  • Four-per-day full dosage of capsule form allows for partial dosing for children, seniors, and pets.
  • Tablet and capsule forms are vegetarian (except for pharmaceutical glaze on tablets).
  • Exclusion of ingredients such as wheat, dairy, corn, soy, and egg having well-known antigenic properties and that may be associated with allergy or delayed hypersensitivity reactions. Contains no GMOs.
  • A minimum of excipients, fillers, lubricants, etc. that exert deleterious effects in some individuals.

Multi Two is a great multivitamin and in many ways similar to the Mighty Multi-Vite!. However, Multi Two provides more B vitamins and in the case of certain B vitamins, it provides twice as much as Mighty Multi-Vite!. For anyone who requires plenty of B vitamins and who doesn’t necessarily want to take a separate, standalone B vitamin formula, Multi Two is an ideal multivitamin.

For more information, see the full Multi Two product page (capsules) or the Multi Two product page for tablets.

 

4. MINI MULTI

We call our Mini Multi the “World’s Purest Multivitamin.” This is because it was originally formulated for chemically and/or environmentally sensitive persons. The capsule is smaller than our other multivitamins which easily allows for partial dosing. It also is our only all coenzyme form multivitamin.

MINI MULTI is an ultrapure, biochemically formulated, complete multivitamin supplement that includes essential and trace minerals, and cofactors. MINI MULTI is highly bioavailable and contained in a preservative-free veggie capsule (helping eliminate chemical contaminants). The capsule contains no fillers, flow agents, or any other excipients. Each component is the highest purity.

MINI MULTI is ideal for chemically and environmentally sensitive individuals who require ultra-high purity supplements. The formula is designed by Dr. Hank Liers, who developed it as a ultra-pure formula for sensitive individuals. Yet, anyone can take MINI MULTI to benefit from its ultra-high purity and avoidance of additives, fillers, or other excipients.

Many individuals who take MINI MULTI are not chemically sensitive, but suffer from allergies, sensitive digestive tracts, wish to avoid gelatin capsules, or simply do not enjoy swallowing large capsules (or tablets).

multivitamins

Meet Mini Multi, the world’s purest multivitamin formulated originally for chemically and environmentally sensitive persons.

ADVANCED DESIGN INCLUDES NEARLY 100% COENZYME FORM B VITAMINS

MINI MULTI’s biochemical formulation incorporates the latest research on nutrient transport and interaction to enhance efficient metabolism and includes coenzyme forms of vitamins. The vitamins and minerals in MINI MULTI activate the body’s metabolic machinery, and synergistic cofactors aid absorption, assimilation, utilization, and metabolism of nutrients.

MINI MULTI is among the first multivitamins to provide almost all coenzyme form B vitamins (i.e., all except vitamin B3, which we include as niacinamide). Coenzyme form vitamins are the natural forms best recognized and utilized in the body. For example, MINI MULTI provides folate in the form of folinic acid (a natural form of folate) from calcium folinate and L-5-MTHF (another natural form of folate), rather than the typical and commonly used folic acid, a synthetic form requiring enzymatic processing in the body for utilization. That is, coenzyme vitamins are easier to assimilate (especially for older individuals or those with health conditions that reduce enzyme activity in vivo) and they are immediately recognized and used in the body.

FEATURES AND BENEFITS OF THE HIGHEST PURITY FORMULA AVAILABLE TODAY

  1. The world’s purest multivitamin supplement, proven for more than a decade
  2. Ideal for chemically, environmentally or allergen sensitive individuals, or anyone desiring an ultra-high purity in a nutritional supplement
  3. Highly effective, complete formula includes vitamins, minerals, and cofactors (including powerful antioxidants)
  4. Includes nearly 100% coenzyme form B vitamins for rapid assimilation (all except B3 which is included as niacinamide and B5 which is included as pantothenic acid)
  5. Convenient four-per-day dosage allows easy for partial dosing
  6. Suitable for vegans and vegetarians (veggie capsule)
  7. Suitable for children (i.e., capsule may be opened and emptied into drinks or food)
  8. No additives, fillers, flow agents, or any other excipients!
  9. Nothing artificial or synthetic!
  10. Gluten-free
  11. In fact, MINI MULTI does not contain wheat, rye, oats, corn, barley, gluten, egg, dairy, citrus, yeast, sugar, GMOs, wax, sulfates, phosphates (other than coenzymes), preservatives, fillers, binders, coatings, colorings, or artificial flavorings

MINI MULTI exhibits superior design, technical sophistication, ease of use, and high perfomance. We suggest you try it whether you are sensitive to fillers or flow agents, suffer from allergies due to common additives, wish to avoid artificial ingredients, or simply want the purest multivitamin available.

In this day and age when many individuals suffer from allergies to ingredient sensitivities, Mini Multi represents a choice for the ultimate in high-purity. No excipients means a cleaner supplement option for anyone who may need it.

5. CHEWABLE KIDS MIGHTY-MULTI

HPDI’s KIDS MIGHTY-MULTI! is truly one-of-a-kind. It is most similar to the Mighty Multi-Vite! in terms of the nutrients it provides, including antioxidants. However, it is our only chewable and it tastes great.

KIDS MIGHTY-MULTI! is an advanced chewable multivitamin for children incorporating the latest nutritional research in a tasty, complete formula combining the highest-quality and most usable forms of vitamins, minerals, herbs, and cofactors.

Our children’s multivitamin formula provides optimal levels of basic essential nutrients and thereby is an ideal foundation upon which to build a complete nutritional supplement program. A high-quality multivitamin is the starting-point for building a program uniquely designed to suit to your child’s individual requirements.

We offer KIDS MIGHTY-MULTI! as a “top-of-the-line” children’s formula that tastes great and produces exceptional results. This unique formula very effectively provides children with a solid foundation of nutrients for establishing, building, supporting, and maintaining excellent health during this critical period of their lives.

COMPLETE FORMULA – the most complete children’s formulas available! It provides a full-spectrum of essential nutrients needed for creating, supporting, and maintaining excellent health for your child. It includes natural coenzyme form vitamins and Krebs cycle bionutrients that work with young bodies to provide energy for metabolic processes, healing, and optimal heatlh.

AMAZING TASTE, NATURALLY the most delicious kids multivitamin you’ll ever taste! Flavored with only healthy, natural sweeteners and functional taste enhancers, including mannitol, xylitol, fructooligosaccharides (FOS) (from chicory root), natural fruit flavor, and stevia leaf extract. Most of these taste enhancers actually exhibit other positive benefits in the body (i.e., prebiotic effects, cavity prevention, and antioxidant action). Kids (and adults) love the taste!

BALANCED ESSENTIAL NUTRIENTS – exceptionally balanced nutrients for supporting your child’s health. This is a foundational formula ideal for providing basic nutrients for health. Indeed, a high-quality multivitamin is a basic foundational formula (along with vitamin C and essential fatty acid formulas) in a nutritional supplement program. Our kids’ formula puts your child on the nutritional track he or she deserves right from the start!

“ULTRA PURE”
– excludes common food source allergens (like wheat, corn, soy, or dairy). Also excludes unnecessary excipients, fillers, binders, and additives. Unlike many children’s vitamins, ours contains NO artificial colorings or flavorings, artificial sweeteners (like aspartame, saccharin, or sucralose) or hydrogenated vegetable oils…substances that can have deleterious effects on health (yet are frequently include. Plus, NO sugar and NO GMOs!

RAPID ASSIMILATION
– incorporates bioavailable vitamin and mineral carriers the body recognizes and can assimilate immediately. Plus, multiple carriers ensure assimilation. Chewable form speeds uptake in the body.

FOUNDATIONAL FORMULA – forms the foundation of a complete supplement program for your child. Formulated to work with other foundational formulas, including Vitamin C formulas (like PRO-C™) and essential fatty acid formulas (like Essential Fats plus E) that together form the basis of a complete nutritional supplement program. You can also add specific supplements addressing your individual needs of your child, i.e., by pinpointing where he or she may require additional nutritional support. Such specific supplements might include Allergy Support Plus, Joint Health Formula, or Ultimate Protector™ (super antioxidant & Nrf2 activator formula).

Kids Mighty-Multi is the perfect multivitamin for kids offering appropriate levels of a wide range of important vitamins, minerals, cofactors, and antioxidants.

KIDS MIGHTY-MULTI! FEATURES

• A full-spectrum of B-complex vitamins primarily in coenzyme forms, including Vitamin B1 (as thiamin diphosphate), Vitamin B2 (as riboflavin-5’-phosphate), Vitamin B3 (as niacinamide and niacin), Pantothenic acid), Vitamin B6 (as pyridoxal 5’-phosphate), folate (as 5-MTHF), Vitamin B12 (as methylcobalamin), and Biotin.

• All of the most absorbable and usable forms of the fat-soluble vitamin group, including Vitamin A (as natural beta-carotene), Vitamin E (as d-alpha tocopherol succinate and mixed tocopherols), Vitamin D3 (as cholecalciferol), and Vitamin K (as phylloquinone (K1) and MK-7 (K2)).

• A complete and balanced supply of the most abundant carotenoids found in the body, including Beta-Carotene, Lycopene, and Lutein.

• A variety of the best-known herbal ingredients, including Quercetin, Grape Extract, Turmeric extract, Broccoli Sprouts Powder, and Octacosanol (from policosanol).

• Readily absorbed forms of all essential minerals, including Calcium, Magnesium, Potassium, Zinc, Iron, Manganese, Boron, Copper, Chromium, Molybdenum, Vanadium, and Selenium.

• Easily assimilated mineral carriers, including ascorbates (Vitamin C), Krebs cycle bionutrients (citrate, succinate, alpha-ketoglutarate, fumarate, malate), and amino acids (e.g., glycine, taurine, and aspartic acid) that provide the body with important metabolic substrates and vitamins.

• Sulfur-containing amino acids supporting the body’s detoxification systems.

• Natural taste-enhancing complex of xylitol, mannitol, FOS, and stevia leaf extract. Tasty fruit flavor kids love!

• Therapeutic levels of xylitol helping to prevent cavities.

• Significant levels of choline and inositol that play a crucial role in all cell membranes, and in brain and liver function.

• Betaine HCl to support digestive processes.

• Exclusion of the pro-oxidant mineral iodine that may lead to excessive free radical production and PABA that can adversely affect brain function. We actually prefer the safer and more therapeutic Nascent Iodine over the forms normally found in vitamin formulas.

• Exclusion of substances that have well-known antigenic properties and that may be associated with allergy or delayed hypersensitivity reactions, including wheat, corn, soy, egg, and dairy.

• Minimum of excipients, fillers, or additives (that may have deleterious effects in some individuals).

• Small tablet size allows for weight-dependent dosing (two tablets per 20 lbs body weight)

MORE ABOUT KIDS MIGHTY-MULTI!

A Better, Safer Multivitamin for Kids

The vast majority of children’s vitamins today are decidedly not advanced formulations. They typically provide only minimum amounts (i.e., no more than government mandated daily values) of vitamins, minerals, and other nutrients. In addition, most kids’ vitamin on the market remain filled with sugars and artificial ingredients, including aspartame (a known toxin), artificial colorings, preservatives, hydrogenated oils, and other toxic substances.

Consider what our Kids Mighty-Multi! does NOT contain:

  • Aspartame. There is controversy surrounding this artificial sweetener, which is associated with a variety of neurological problems. In fact, there is widespread consensus that children under six should not use aspartame. We believe no one should consume aspartame at any age!
  • Refined sugars (usually listed as, sucrose, etc.). There is no place for sugar in multivitamins. Sugar in supplements is also dangerous because when coupled with ascorbic acid, it can damage teeth! Chewable kids vitamins containing sugar expose your child’s teeth to double jeopardy.
  • Artificial dyes (FD&C Yellow, Blue, and/or Red). Artificial colors are associated with a wide range of health and behavioral problems. These include carcinogenicity, and contributing to learning problems like ADHD. In addition, FD&C Yellow dye #5 (tartrazine) is one of the main food triggers of asthma attacks.
  • Benzoates, sulfur dioxide, sulfites. These are bad because they are all preservatives that have no business being in a health supplement. They all are known to stimulate allergic reactions.
  • Hydrogenated oils. These are the bad, sticky fats that are found in junk foods and are harmful to your child’s heart. Incredibly, some companies put hydrogenated oils in a children’s vitamin!

As you can see, our children’s chewable multivitamin is not your ordinary kids multivitamin, and it provides all the benefits of our other multivitamins in a tasty chewable format. In fact, many adults take it who prefer a chewable over a capsule or tablet. It is uniquely formulated to be scalable for adults at the dosage of two tablets per 20 lbs body weight.

multivitamins

Chewable Kids Mighty-Multi tastes great, provides advanced forms of nutrients, and scales up for adults.

CONCLUSION: TAKE A MULTIVITAMIN

Multivitamins are the first supplement most people need and should take. Taking a high-potency, high-purity multivitamin daily provides many benefits beyond what you might expect. This includes everything from ensuring against deficiencies to providing amounts necessary for optimal health, and for compensating for greater needs depending on your unique biochemical individuality. Given the overarching safety and relatively low cost of multivitamins, they are best “first defense” in a nutrient-depleted world.

HPDI offers four of the best multivitamins available anywhere, and five if you consider that Multi Two is available in capsules or tablets. So take your pick among them, and be the healthiest you can be.

MULTIVITAMIN RESOURCES

HPDI Multivitamins

Mighty Multi-Vite!

Multi Two (Capsules)

Multi Two (Tablets)

Mini Multi

Kids Mighty-Multi! (Chewable)

ARTICLES & e-BOOKS

“Why You Need Foundational Supplements”

The Need for Foundational Supplements e-book (.pdf)

“Rejuvenation Program Part Four”

“Choosing Supplements for a Complete Nutritional Supplements Program”

Discovering Nutritional Needs Through Advanced Genetic Testing

No Deaths from Vitamins. None. Safety Once Again Confirmed by America’s Largest Database” (Orthomolecular News Service, 2017)

VIDEOS

HPDI Foundational Supplements – VIDEO

Health Products Distributors, Inc.