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OMEGA-3 ESSENTIAL FATS REMAIN “ESSENTIAL” – A REBUTTAL FROM OMNS

Fred Liers PhD omega-3 essential fats plus e EFA formulaOmega-3 essential fatty acids (EFA) are critically important for health. That is the reason we at HPDI include them in our foundational supplements system in the form of our Essential Fats Plus E formula. Essential Fats Plus E provides a balanced ratio of 4:1 omega-3 EPA to omega-6 GLA fatty acids proven to optimally support health.

As important as Omega-3 fats are in good health, various studies conclude they are of little value. In order to help clarity the fallacies found in such studies, this month we re-print the recent article “Omega 3 Fatty Acids and Cardiovascular Disease” from the Orthomolecular News Service (OMNS).

BACKGROUND

Essential fats including Omega-3 and Omega-6 are so important to health that we consider them as foundational or “core” to basic nutrition as multivitamins, antioxidants/vitamin C formulas, and high-RNA superfoods, like Rejuvenate! Plus.

Many of today’s health problems relate to deficiencies in Omega-3 essential fatty acids rather than overabundance of it. It makes sense for everyone to supplement their diets with at least a minimum amount of essential fats. This is addition to consuming foods high in Omega-3 (and Omega-6) essential fats, including leafy greens, nuts, seeds, and seed oils. Also, small amounts of wild-caught fish from clean waters. Preferably these fish would come from low on the food chain, such as sardines, herring, or young mackerel, for example.

In December 2107, my father Hank Liers, PhD, wrote “The Truth about Essential Fatty Acids.” In his article, he delves into detail about why essential fatty acids are critical for health.

The diagram below from Dr. Hank’s article shows in detail the pathways for the production and use of fatty acids in the body. In the figure the metabolic pathways (running left to right) for four fatty acids types are shown (top – Omega-3, second – Omega-6, third – Omega-9, bottom – Omega-7). Notice that only the omega-3 and omega-6 oils are considered to be essential fatty acids because they cannot be made in the body. This means they must come from food.

omega-3 fats omega-6 fats

Furthermore, an additional diagram from Dr. Hank’s article shown below provides details of the omega-6 and omega-3 pathways. Pathway specifics indicate key eicosanoids (series 1 prostaglandins [anti-inflammatory], series 2 prostaglandins [pro-inflammatory], and series 3 prostaglandins [anti-inflammatory]), oil sources, and important nutrient cofactors that are needed for the reactions to take place.

omega-3 fats omega-6 fats

In particular, Dr. Hank discusses how superior benefits to health result from a balanced 4:1 ratio between Omega-3 eicosapentanoic acid (EPA) fatty acids and Omega-6 gamma linoleic acid (GLA).

Below we list some of the functions and benefits obtained when by diet or supplementation the correct ratios and amounts of essential fatty acids are consumed.

• Regulate steroid production and hormone synthesis
• Regulate pressure in the eyes, joints, and blood vessels
• Regulate response to pain, inflammation, and swelling
• Mediate Immune Response
• Regulate bodily secretions and their viscosity
• Dilate or constrict blood vessels
• Regulate smooth muscle and autonomic reflexes
• Are primary constituents of cellular membranes
• Regulate the rate at which cells divide
• Necessary for the transport of oxygen from the red blood cells to tissues
• Necessary for proper kidney function and fluid balance
• Prevent red blood cells from clumping together
• Regulate nerve transmission

Dr. Hank also discusses the fallacy of thinking that supplemental Omega-3 fats alone are sufficient to produce health. That is, despite the relative lack of Omega-3 essential fats and the prevalence of Omega-6 fats in modern diets, it is nevertheless the forms (EPA and GLA)—and the critical 4:1 ratio between them—that makes the difference in how they act synergistically for health. The result of Hank’s scientific understanding of essential fatty acids has resulted in his formulation of a balanced EFA product, Essential Fats Plus E.

Orthomolecular Medicine News Service Article “Omega 3 Fatty Acids and Cardiovascular Disease”

Regarding the Orthomolecular Medicine News Service article “Omega 3 Fatty Acids and Cardiovascular Disease” (republished below) rebutting the “Cochrane Database of Systematic Reviews” which relies on so-called “Evidence Based Medicine” (EBM) to distort truth on Omega-3 essential fatty acids, the fact that Omega-3 fats are under such false attack represents a huge disservice to the public.

While essential fatty acids may not generate profits for corporations—and in fact may lead to improved health outcomes that threaten the use of chemicals and drugs—essential fats nevertheless remain foundational for health.

Above we have shown the important reasons Omega-3 fats and other essential fatty acids are scientifically termed “essential.” And why people continue taking essential fats, and giving them to their families and children, for supporting health and well-being. Primary among these reasons is that you cannot be healthy without them. Hence, they are essential. Why believe anyone who says otherwise?

The bottom line: Omega-3 essential fatty acids are critical for health. Supplementing the diet with them is a good idea for nearly everyone. This is especially true because typical diets are proven to be most deficient in Omega-3 among essential fats.

Below we re-print in full the recent article “Omega 3 Fatty Acids and Cardiovascular Disease” from the Orthomolecular News Service (OMNS) for the benefit of our HPDI blog readers. ~

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FOR IMMEDIATE RELEASE
Orthomolecular Medicine News Service, Aug 6, 2018

Omega-3 Fatty Acids and Cardiovascular Disease

Commentary by Damien Downing, MBBS, MSB and Robert G. Smith, PhD

The Cochrane Database of Systematic Reviews has just updated its own review: Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease [1]. Here’s our take on it.

Michael Pollan, the brilliant food writer, reckoned you could sum up what to do about nutrition and diets in 7 words; “Eat food, not too much, mostly plants.” That sums up both what’s best for humans and what’s best for the planet.

We reckon you can sum up what’s wrong with evidence-based medicine (EBM) in 10 words; “Evidence is a waste of data; systematic reviews are palimpsests.” You can use that as a knife to quickly dissect this study.

There are many things wrong with this review. Somebody’s PR department has spun the review’s “no clear evidence of benefit” into “evidence of no benefit” – absence of evidence becoming evidence of absence. And clearly the media were entirely happy to take that one and run with it.

Systematic reviews are palimpsests

What’s a palimpsest? Back when things got written on vellum, an animal skin, not on paper, you didn’t throw it away; you recycled it and wrote over the original. It was called a palimpsest.

A systematic review gives an opportunity to write over the conclusions of a whole list of papers with your new version of the truth. You do that by the way that you select and exclude them.

For instance there was a meta-analysis (that’s a systematic review with more numbers) in 2005 that concluded that vitamin E supplements significantly increased the risk of death [2]. The way they did that was to rule out any study with less than 10 deaths – when fewer deaths was exactly the outcome they were supposed to be looking for.

The reason they gave for doing that was “because we anticipated that many small trials did not collect mortality data.” We’re not buying it; they used it as a trick to enable them to get the negative result they wanted – to over-write the findings of a long list of original studies.

And here we have authors doing the very same thing in this omega-3 study – and upping the ante slightly. Now the threshold is 50 deaths. Fewer than that and your study is ruled out of the final, supposedly least biased, analysis . . on the grounds that it’s more biased.

We don’t know how they could keep a straight face while saying (our interpretation); “The studies with fewer deaths showed more benefit from omega-3s, so we excluded them.” At least that’s what happened back in 2004 when the first version of this came out.[3]

But this is the 8th update (we think) and they no longer bother to tell you about what they included or excluded in detail, so we can only assume that if they had changed that exclusion they would have told us.

The weird thing is that they are allowed to do it. Nutrition researcher Dr. Steve Hickey has shown that in systematic reviews there is generally control for bias in the included studies, but none for bias in the actual review and its authors.[4,5]

They found not one example of adequate blinding among 100 Cochrane reviews (like this one); they could all be palimpsests. Do we know that they are fake? No, but it doesn’t matter: what we do know is that we can’t trust them. Nor can we trust this Cochrane review. Things haven’t changed since 2004.

Evidence is a waste of data

Evidence is what lawyers and courts use to find someone Guilty or Not Guilty, and we all know how that can go wrong. It’s a binary system: you’re either one or the other. But at least if you’re on trial all the evidence should be about you and whether you did the crime.

In EBM the evidence is all about populations, not about individuals. When a doctor tells you “There’s a 1 in 3 chance this treatment will work” he is required to base that on big studies, or even systematic reviews. You don’t, and you can’t, know what that means for you because very likely you don’t fit the population profile.

As Steve Hickey (again) said, the statistical fallacy underlying all this states that you have one testicle and one ovary – because that’s the population average! The authors of this study update started off with about 2100 papers that looked relevant. They then excluded 90 per cent of them for various reasons – some of them good reasons, some not.

A smarter way to work would be to data-mine them and look for useful information about sub-groups and sub-effects in all the papers. Is there a particular reason omega-3s might work for you and not for others? Perhaps you can’t stand fish, or are allergic to them, and so are deficient in omega-3s.

But the review system doesn’t allow it, it insists on overall conclusions (about populations), and that’s a colossal waste of data. It also confounds the overall finding of the review – it biases it in fact.

Here’s an example: while most subgroups that made it to the final analysis showed a small reduction in risk from taking omega-3s in one form or another (pills, food, whatever), those who got it from supplemented foods, which we understand means stuff like margarine with added omega-3, showed a 4.3-fold death risk increase!

The problem here is that the effects of omega-3 fatty acids cannot be studied alone as if they were a drug. What counts are all the other components of the diet that affect a person’s health.

Processed foods and drinks that contain many unhealthy ingredients can’t be made healthy by adding small doses of vitamins, minerals, and omega-3 fatty acids. In fact, many processed foods that contain small doses of vitamins and other essential nutrients are unhealthy because they contain large doses of sugar, salt, and harmful ingredients such as preservatives, dyes, and other non-food items.

Why lipids are so important

Part of the problem is that lipids are truly complicated, and not many people, patients, doctors or even scientists, understand them well. You need a good understanding of lipid metabolism to appreciate the difference in metabolism and impact between alpha-linolenic acid (ALA, in food such as oily fish) and extracted oils such as EPA and DHA that are only found at high levels in omega-3 supplements.

At these levels they are effectively new to nature; nobody, indeed no mammal, was exposed to really high doses of DHA until we invented fish oil supplements [6]. Miss that fact and you miss the difference between having people eat fresh oily fish or just using omega-3 margarine!

We know from a variety of studies that a diet containing generous portions of green leafy and colorful vegetables and fruits, moderate portions of eggs, fish, and meat, and supplements of adequate doses of essential nutrients (vitamins and minerals) is effective at lowering the risk for cardiovascular disease.

Adequate doses of both omega-3 (in flax oil, walnuts, fish) and omega-6 (in seed oils such as canola, soybean, peanut) fatty acids are essential for health. Although essential, omega-6 fatty acids are thought to contribute to inflammation throughout the body whereas omega-3 fatty acids are anti-inflammatory.

Omega-3 fatty acids are essential for most body organs including the brain but are found in lower levels than omega-6 fatty acids in most vegetables. Risk for cardiovascular disease can be lowered by adequate doses of vitamins C (3,000-10,000mg/d), D (2,000-10,000 IU/d), E (400-1,200 IU/d), and magnesium (300-600 mg/d) in addition to an excellent diet that includes an adequate dose of omega-3 fatty acids.[7]

(Dr. Damien Downing is a specialist physician practicing in London, and President of the British Society for Ecological Medicine. Robert G. Smith is a physiologist and Research Associate Professor at the University of Pennsylvania Perelman School Of Medicine.)

 

References:

1. Abdelhamid, A, Brown TJ, Brainard JS, et al., (2018) Omega 3 fatty acids for the primary and secondary prevention of cardiovascular disease. Cochrane Database of Syst Rev. 7:CD003177. https://www.ncbi.nlm.nih.gov/pubmed/30019766
http://cochranelibrary-wiley.com/doi/10.1002/14651858.CD003177.pub3/abstract

2. Miller ER, Pastor-Barriuso R, Dalal D, et al., (2005) Review Meta-Analysis?: High-Dosage Vitamin E Supplementation May Increase. Annals of Internal Medicine, 142(1), pp.37-46. Available at: http://annals.org/article.aspx?articleid=718049.

3. Hooper L, Thompson RL, Harrison RA, et al.. (2004) Omega 3 fatty acids for prevention and treatment of cardiovascular disease. Cochrane Database Syst Rev. (4):CD003177. http://cochranelibrary-wiley.com/doi/10.1002/14651858.CD003177.pub2/abstract

4. Hickey S, Noriega LA. Implications and insights for human adaptive mechatronics from developments in algebraic probability theory, IEEE, UK Workshop on Human Adaptive Mechatronics (HAM), Staffs, 15-16 Jan 2009.

5. Hickey S, Hickey A, Noriega LA, (2013) The failure of evidence-based medicine? Eur J Pers Centered Healthcare 1: 69-79. http://ubplj.org/index.php/ejpch/article/view/636

6. Cortie CH, Else, PL, (2012) Dietary docosahexaenoic acid (22:6) incorporates into cardiolipin at the expense of linoleic acid (18:2): Analysis and potential implications. International Journal of Molecular Sciences, 13(11): 15447-15463. http://www.mdpi.com/1422-0067/13/11/15447

7. Case HS (2017) Orthomolecular Nutrition for Everyone. Turner Publication Co., Nashville, TN. ISBN-13: 978-1681626574

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THE TRUTH ABOUT ESSENTIAL FATTY ACIDS

The Truth About Essential Fatty Acids

Dr. Hank Liers, PhD essential fatty acidsMany in the field of nutrition have lost sight of the fact that there are two essential fatty acids needed by the body. Many people recommend omega-3 fatty acids assuming the the body gets sufficient omega-6 from the diet. The truth about essential fatty acids is more complicated. This article will show the more complete and correct picture.

BACKGROUND

Fatty acids are part of the lipids class, widely found in nature, food, and organisms. These fatty acids are a critical constituent of the cell membranes in all of the trillions of cells in the body. They have important biological functions including structural, communication, and metabolic roles, and they represent an important source of energy. Their metabolism produces a huge quantity of adenosine triphosphate (ATP). The beta-oxidation of the fatty acids is a well-known process, mostly used by the heart and the muscular tissue to obtain energy.

Figure 1 below shows a schematic diagram of what a fatty acid looks like. One end of the structure in all cases has a carboxylic acid group (COOH) and the other end in all cases has a methyl group (CH3). Saturated fats have single bonds (-) between all carbon atoms (C), but unsaturated fats have a number of double bonds (=) between some of the carbon atoms.


essential fatty acids

Figure 1 – Basic diagram of fatty acids structure

The human body can synthesize many of these fatty acids, except the essential fatty acids (PUFAs) linoleic acid (LA) and alpha-linolenic acid (ALA). These two are generally found in various vegetable oils, but their important metabolites are found mainly in special vegetable oils such as borage oil and in fish oils. Linoleic acid is the most abundant fatty acid in nature, and it is the precursor of other omega-6 fatty acids. Omega-3 fatty acids are synthesized from alpha-linolenic acid.

Once ingested, short-chain PUFAs are converted to long-chain fatty acids. These are critical for mammalian cells in order to perform various biological functions, such as sustaining the structural integrity of cellular membranes and serving as signaling molecules. They are highly enriched in brain tissues, where they participate in the development and maintenance of the central nervous system during both embryonic and adult stages.

Polyunsaturated fatty acids have been extensively researched. They include the essential fatty acids linoleic acid (an omega-6) and alpha linolenic acid (an omega-3). Omega-3s are not abundant in our food chain. There is none in corn oil and very little in soy oil, the two most widely used food oils. Therefore, nearly all the early research with polyunsaturated oils utilized omega-6 fatty acids, predominantly as linoleic acid.

Fish oils were neglected out of ignorance or because the investigators chose to pass over these cholesterol-containing oils. Concern eventually developed over the close association between increasing incidence of mammary tumors and high intake of omega-6 polyunsaturated fatty acids. After some years, researchers finally turned their investigations to the interrelationship between dietary omega-6 and omega-3 fatty acids.

FATTY ACID METABOLIC PATHWAYS

The following diagram shows in detail the pathways for the production and use of fatty acids in the body. In the figure the metabolic pathways (running left to right) for four fatty acids types are shown (top – Omega-3, second – Omega-6, third – Omega-9, bottom – Omega-7). Notice that only the omega-3 and omega-6 oils are considered to be essential fatty acids because they cannot be made in the body. This means they must come from food.

essential fatty acids

Figure 2 – fatty acid metabolism pathways in the body

The diagram shows a series of enzyme induced reactions that either add a double bond or two additional carbon/hydrogen pairs to the fatty acid. The enzymes that make this happen are called desaturase and elongase. The desaturase enzymes are given a number for the carbon number (that the enzyme is working on) from the methyl end of the fat. These same enzymes work on all of the fatty acid types. For example, Delta 6 desaturase causes an additional double bond to be inserted into both alpha-linolenic (omega-3) and linoleic acid (omega-6) (as well as oleic acid and palmitoleic acids).

In this way, the body is able to produce a wide variety of fatty acids that have their own unique effects on biochemistry. Some of these are more important than others. In particular, the omega-3 essential fatty acid eicosapentanoic acid (EPA), the omega-6 essential fatty acid dihomo-gamma-linolenic acid (DGLA), and the omega-6 essential fatty acid arachidonic acid (AA) are precursors for a class of chemicals called eicosanoids/prostaglandins that have far reaching affects on key body functions.

EICOSANOIDS/PROSTAGLANDINS

Eicosanoids are prostaglandins that affect many aspects of health both positively and, in some cases, negatively. All known eicosanoids and prostaglandins are formed from the essential fatty acids linoleic acid (omega-6, or n-6), alpha linolenic acid (omega-3, or n-3), their “enhanced” derivatives, and from the omega-3 fatty acids in fish oils.

Prostaglandins are short-lived highly active, hormone-like chemicals that are found in every cell of the body. They are regulators of cell activity and essential for maintaining health. Each cell type or organ produces its own form of prostaglandin to carry out its functions. There are three types of prostaglandins: PG1, PG2, and PG3.

Series 1 Prostaglandins (PG1), derived from gamma-linolenic acid (GLA), the active component of borage oil, has many beneficial effects: It makes platelets less sticky, lowers blood pressure by relaxing smooth muscles in the walls of arteries, increases loss of sodium and water, decreases inflammation and enhances immunity.

Series 2 Prostaglandins (PG2), also derived from GLA, is used in “fight or flight” (stress) situations, – the fight against danger, or the flight from it. In modern lifestyles which are high in stress but low in physical activity, continuous production of Series Two Prostaglandins results in sticky platelets, high blood pressure, increased water and sodium retention, increased inflammation and decreased immune system capabilities.

Series 3 Prostaglandins (PG3), derived from eicosapentaenoic acid (EPA), the active component of fish oil, has beneficial effects. They block the detrimental effect of the Series 2 Prostaglandins, preventing them from being made in the body. As a result the platelets are less sticky, blood pressure is lower because the muscles in the walls of our arteries remain relaxed, loss of sodium and water by the kidneys takes place more effectively, inflammation response is decreased, and immune function is efficient.

It is now known that the ratios of these dietary fatty acids are very important. Consumption of linoleic acid leads to production of the enhanced fatty acid, arachidonic acid (20:4n-6). Prostaglandins based on arachidonic acid exacerbate stress and inflammatory states, and suppress immunoprotective functions (i.e. resistance to disease). Too much linolenic acid and other omega-3s may cause excessive bleeding during injury, surgery, or childbirth. Large amounts of any of these unsaturated fatty acids in the diet without a compensatory increase in antioxidant nutrients (especially Vitamin E), can speed oxidative damage to tissues, resulting in accelerated aging while increasing the risk of degenerative diseases.

Yet, a balanced ratio of both omega-3 and omega-6 fatty acids in the diet offers very positive health benefits. When omega-3 fatty acids predominate, the body will produce less arachidonic acid (20:4n-6). Immunity improves and inflammation subsides.

Essential Fats

Unfortunately, our Western diet has been almost devoid of omega-3 fatty acids. Creating the optimum intake of omega 3-to-omega 6 unsaturated fatty acids has become, therefore, an issue of prime importance for anyone concerned with health. We need to evaluate carefully the amounts of linoleic acid (n-6) we consume relative to our intake of alpha-linolenic acid (18:3n-3) and fish oils (EPA:20:5n-3 and DHA:22:6n-3).

ESSENTIAL FATTY ACIDS – PATHWAYS

The diagram in Figure 3 shows details of the omega-6 and omega-3 pathways. Pathway specifics indicate key eicosanoids (series 1 prostaglandins, series 2 prostaglandins, and series 3 prostaglandins), oil sources, and important nutrient cofactors that are needed for the reactions to take place.

essential fatty acids

Figure 3 – Essential Fatty Acids – pathways in the body

The information is this diagram gives the clues we need in order to provide optimal types and amounts of omega-6 and omega-3. For example, I have chosen for my essential fatty acid product cold pressed borage oil as the best natural source of gamma linoleic acid (GLA). It contains 20% by weight — the highest amount found in natural oils.

RESEARCH ON ESSENTIAL FATTY ACIDS

Work by Chapkin et. al. (see references 1–4 below) has identified the potent synergistic relationship between GLA, an omega-6 fatty acid, and the well-known omega-3 fatty acids. Chapkin has shown that, rather than simply the quantity of dietary omega-3s, it is the ratio of omega-6 to omega-3 fatty acids that is important in achieving full cardiovascular health and inflammatory control.

Furthermore, Chapkin has identified the ideal ratio. His published work deals with the importance of mixed diets supplying both linoleic and linolenic acids. To underscore the importance of these two fatty acids, refined oil supplements rich in enhanced forms were used. “Enhanced forms” are fatty acids derived from the original. They are one or more steps closer to the actual eicosanoid. In the human body, alpha linolenic acid (18:3n-3) is eventually converted to eicosapentaenoic acid (EPA, 20:5n-3) and linoleic acid (18:2n-6) is converted to gamma-linolenic (GLA, 18:3n-6) as its first enhanced form. Both enhanced fatty acids are precursors to eicosanoids.

In Chapkin’s research, superior health benefits were delivered by the mixed diet that supplied the eicosanoid precursors in a specific ratio. The balanced ratio of enhanced Omega-6 (GLA)-to-Omega-3 (EPA) fatty acids was 1:4.

IMPLEMENTATION OF THE SCIENCE

Based upon the science discussed above, I developed a product with the correct Omega-6 (GLA)-to-Omega-3 (EPA) ratio and with proper amounts. It is available to you as Hank & Brians Essential Fats Plus E from Health Products Distributors, Inc. (HPDI).

Essential Fats Plus E

ESSENTIAL FATS PLUS E IS A HIGHLY ADVANCED ESSENTIAL FATTY ACIDS SUPPLEMENT
OFFERING SPECIAL BENEFITS:

  1. UNIQUE COMBINATION — Essential Fats (EPA, DHA, GLA) plus Vitamin E. This unique formula offers more than one type of Vitamin E (not just d-alpha-tocopherol) and balanced essential fats.
  2. BALANCED ESSENTIAL FATS— Many EFA supplements contain only omega-3s, but for optimal function the body requires a balance of omega-3 and omega-6 essential fats. In addition, our special formula provides a 4-to-1 ratio of EPA to GLA in order to achieve a balance you need for optimal health.
  3. FULL-SPECTRUM VITAMIN E — Tocotrienols and tocopherols in this formula are natural vitamin E substances derived from oryza rice bran oil and protect polyunsatured EFAs against free-radical damage both in the capsule and in your body. Many Vitamin E supplements contain only d-alpha tocopherol, which is only a single component of the full-spectrum Vitamin E in this formula.
  4. ULTRAPURE — Molecularly distilled oils of extremely high-purity containing no PCBs, heavy metals, or oxidized contaminants. Free of excipients, additives, and common food allergens!

COMPOSITION: Six softgel capsules provides the following percentages of the Daily Value.

NUTRIENT AMOUNT % Daily Value†
EPA (Eicosapentaenoic Acid 20:5 omega 3)
(from 2,000 mg of purified fish oils)
360 mg *
DHA (docosahexaenoic Acid 22:6 omega 3)
(from 2,000 mg of purified fish oils)
240 mg *
GLA (Gamma Linolenic Acid 18:3 omega 6)
(from 450 mg of cold pressed borage seed oil)
90 mg *
Vitamin E (d-alpha-tocopherol) (from 180 mg of Oryza rice bran oil) 24 IU 81%
Mixed Tocotrienols (d-gamma, d-alpha, and d-delta)
(from 180 mg of Oryza rice bran oil)
28.8 mg *

* No established Daily Value
† Daily Values based on a 2,000 calorie diet

IMPORTANT FUNCTIONS OF ESSENTIAL FATTY ACIDS

Below we provide some of the functions and benefits obtained when by diet or supplementation the correct ratios and amounts of essential fatty acids are consumed.

• Regulate steroid production and hormone synthesis
• Regulate pressure in the eyes, joints, and blood vessels
• Regulate response to pain, inflammation, and swelling
• Mediate Immune Response
• Regulate bodily secretions and their viscosity
• Dilate or constrict blood vessels
• Regulate smooth muscle and autonomic reflexes
• Are primary constituents of cellular membranes
• Regulate the rate at which cells divide
• Necessary for the transport of oxygen from the red blood cells to tissues
• Necessary for proper kidney function and fluid balance
• Prevent red blood cells from clumping together
• Regulate nerve transmission

GENETIC TESTING AND ESSENTIAL FATTY ACIDS

Please note that genetic testing for a wide range of genes and the enzymes they produce has indicated that essential fatty acids can be an important factor in helping the body overcome a variety negative gene variations. These negative gene variations include genes that relate to: 1) Inflammatory Response, 2) Exercise Performance, 3) Exercise Recovery, 4) Cardiovascular Fitness, 5) Body Composition, and 6) VO2 Max, Aerobic Capacity.

We will discuss this more deeply in a future blog article.

CONCLUSION

The body is best protected from a range of health issues when we supply a mixed diet of both omega-3 and omega-6 essential fatty acids. Studies show that we do not need to consume large amounts of fatty acids if the ratio is correct. These findings indicate that, for a typical human body, amounts of 90 mg GLA (18:3n-6) to 360 mg EPA (20:5n-3) taken daily will provide for the optimum production of the three major prostaglandins. These amounts are found in Hank & Brians Essential Fats Plus E.

REFERENCES

The following includes abstracts of Chapkin’s published research on essential fatty acids.

REFERENCE 1

Chapkin RS Somers SD Erickson KL

Dietary manipulation of macrophage phospholipid classes: selective increase of dihomogammalinolenic acid.

In: Lipids (1988 Aug) 23(8):766-70

Because alterations in the dietary content of fatty acids are an important method for modulating macrophage eicosanoid production, we have quantitated the levels of n-6 and n-3 polyunsaturated fatty acids in peritoneal macrophage individual phospholipids from mice fed diets (3 wk) with either safflower oil (SAF), predominantly containing 18:2n-6, borage, (BOR) containing 18:2n-6 and 18:3n-6, fish (MFO) containing 20:5n-3 and 22:6n-3, and borage/fish mixture (MIX) containing 18:2n-6, 18:3n-6, 20:5n-3 and 22:6n-3. Dietary n-3 fatty acids were readily incorporated into macrophage phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylserine (PS) and phosphatidylinositol (PI). The increase in n-3 fatty acid levels was accompanied by a decrease in the absolute levels of 18:2n-6, 20:4n-6 and 22:4n-6 in PC, PE and PS. Interestingly, PI 20:4n-6 levels were not significantly lowered (P greater than 0.05) in MIX and MFO macrophages relative to SAF and BOR. These data demonstrate the unique ability of this phospholipid to selectively maintain its 20:4n-6 levels. In BOR and MIX animals, 20:3n-6 levels were significantly increased (P less than 0.05) in all phospholipids relative to SAF and MFO. The combination of borage and fish oils (MIX diet) produced the highest 20:3n-6/20:4n-6 ratio in all phospholipids. These data show that the macrophage eicosanoid precursor levels of 20:3n-6, 20:4n-6 and n-3 acids can be selectively manipulated through the use of specific dietary regimens. This is noteworthy because an increase in phospholipid levels of 20:3n-6 and 20:5n-3, while concomitantly reducing 20:4n-6, may have therapeutic potential in treating inflammatory disorders.

Institutional address: Department of Human Anatomy School of Medicine University of California Davis 95616.

 

REFERENCE 2

Chapkin RS Carmichael SL

Effects of dietary n-3 and n-6 polyunsaturated fatty acids on macrophage phospholipid classes and subclasses.

In: Lipids (1990 Dec) 25(12):827-34

This study examined the effects of n-3 and n-6 polyunsaturated fatty acid alimentation on murine peritoneal macrophage phospholipids. Mice were fed complete diets supplemented with either corn oil predominantly containing 18:2n-6, borage oil containing 18:2n-6 and 18:3n-6, fish/corn oil mixture containing 18:2n-6, 20:5n-3 and 22:6n-3, or fish/borage oil mixture containing 18:2n-6, 18:3n-6, 20:5n-3 and 22:6n-3. After two weeks, the fatty acid levels of glycerophosphoserines (GPS), glycerophosphoinositols (GPI), sphingomyelin (SPH), and of the glycerophosphocholine (GPC) and glycerophosphoethanolamine (GPE) phospholipid subclasses were determined. We found that mouse peritoneal macrophage GPC contain primarily 1-O-alkyl-2-acyl (range for the dietary groups, 24.6-30.5 mol %) and 1,2-diacyl (63.2-67.2 mol %), and that GPE contains 1-O- alk-1′-enyl-2-acyl (40.9-47.4 mol %) and 1,2-diacyl (44.2-51.2 mol %) subclasses. In general, fish oil feeding increased macrophage 20:5n-3, 22:5n-3 and 22:6n-3 levels while simultaneously reducing 20:4n-6 in GPS, GPI, GPE and GPC subclasses except for 1-O-alk-1′-enyl-2-acyl GPC. Administration of 18:3n-6 rich diets (borage and fish/borage mixture) resulted in the accumulation of 20:3n-6 (2-carbon elongation product of 18:3n-6) in most phospholipids. In general, the novel combination of dietary 18:3n-6 and n-3 PUFA produced the highest 20:3n-6/20:4n-6 phospholipid fatty acid ratios. This study demonstrates that marked differences in the responses of macrophage phospholipid classes and subclasses exist following dietary manipulation.

 

REFERENCE 3

Fan YY Chapkin RS

Mouse peritoneal macrophage prostaglandin E1 synthesis is altered by dietary gamma-linolenic acid.

In: J Nutr (1992 Aug) 122(8):1600-6

The ability of dietary gamma-linolenic acid [18:3(n-6)] to modulate prostaglandin biosynthesis in mouse resident peritoneal macrophages was determined. Mice were fed diets containing corn oil, borage oil or evening primrose oil or a mixture of borage and fish oils. After 2 wk, resident peritoneal macrophages were isolated and stimulated with unopsonized zymosan to induce prostaglandin synthesis. Borage oil, primrose oil and fish-borage oil mixture dietary groups (containing 25.6, 11.9 and 19.5 g gamma-linolenic acid/100 g fatty acids, respectively) had significantly (P less than 0.05) enhanced prostaglandin E1 synthesis (39.7, 29.4 and 73.0 nmol prostaglandin E1/mg protein, respectively) compared with corn oil-fed (containing less than 0.1 g gamma-linolenic acid/100 g fatty acids) animals, which synthesized less than 0.1 nmol prostaglandin E1/mg protein. Borage oil- and fish-borage oil mixture-fed mice had the highest biosynthetic ratio of prostaglandin E1/prostaglandin E2 (E1/E2 approximately 0.2). Macrophages from borage oil-fed mice synthesized the lowest amount of prostacyclin (198.7 nmol 6-keto-prostaglandin F1 alpha/mg protein) compared with corn oil-, primrose oil- and fish- borage oil mixture-fed mice (379.7, 764.8 and 384.2 nmol 6-keto- prostaglandin F1 alpha/mg protein, respectively). In addition, borage oil-, primrose oil- and fish-borage oil mixture-fed mice had significantly (P less than 0.05) higher levels of dihomo-gamma- linolenic acid [20:3(n-6)] in membrane phospholipids (5.5, 3.5 and 5.7 mol/100 mol, respectively) relative to corn oil-fed mice (2.0 mol/100 mol).

 

REFERENCE 4

Fan YY Chapkin RS Ramos KS

Dietary lipid source alters murine macrophage/vascular smooth muscle cell interactions in vitro.

In: J Nutr (1996 Sep) 126(9):2083-8

This study was conducted to compare the impact of dietary lipids on the ability of macrophages to modulate vascular smooth muscle cell (SMC) DNA synthesis in vitro. C57BL/6 female mice were fed six different diets (6 mice/diet) containing 10% fat from corn oil (CO), borage oil (BO), primrose oil (PO), fish-corn oil mix (FC, 9:1, w/w), fish-borage oil mix (FB, 1:3, w/w), or fish-primrose oil mix (FP, 1:3, w/w) for 2 wk. Peritoneal macrophages were isolated from these mice, stimulated with zymosan or vehicle, and subsequently co-cultured with naive mouse aortic SMC in the presence of 3H-thymidine to measure SMC DNA synthesis. In this co-culture system, macrophages were seeded on 25-mm culture inserts (upper chamber) and SMC were seeded on 35-mm culture dishes (lower chamber). The two cell types were separated by a semipermeable membrane with a 30-kD cut-off. When quiescent SMC were co-cultured with macrophages, only the PO and FP diet groups had significantly (P < 0.05) lower SMC DNA synthesis compared with the control CO group whose diet contained no gamma- linolenic acid (GLA) or (n-3) polyunsaturated fatty acids (PUFA). In contrast, when cycling SMC were co-cultured with diet-modulated macrophages, all dietary groups except for those fed FC had significantly lower (P < 0.05) SMC DNA synthesis relative to the CO group. Although the level of GLA in PO and BO diets was different (11.5 and 22.3 g/100 g fatty acids, respectively), these treatments exerted comparable inhibitory effects on SMC DNA synthesis. The FP treatment consistently exhibited the lowest SMC DNA synthetic profile among the six dietary groups irrespective of SMC growth conditions. These data suggest that BO and PO alone or in combination with fish oil influence macrophage/smooth muscle cell interactions in a manner consistent with favorable modulation of the atherogenic process.

These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

BOOKS

  1. Enig, Mary G. Know Your Fats: The Complete Primer for Understanding the Nutrition of Fats, Oils, and Cholesterol. Bethesda Press, 2000.
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REJUVENATE! – THE ORIGINAL, HIGH-RNA SUPERFOOD

Fred Liers PhD Rejuvenate high-RNA superfood original greensLast fall, Dr. Hank wrote a short article about original Rejuvenate!™ superfood titled, “High-RNA Rejuvenate! Superfood.” In that article, he highlighted some of the history behind HPDI’s discovery of the health benefits of dietary nucleic acids. He also described the development of the first superfood formulated specifically to provide high levels of dietary nucleic acids (RNA, DNA, nucleotides, and nucleosides).

Since then, we have written several articles about dietary nucleic acids and our high-RNA Rejuvenate! superfoods, including Rejuvenate! Berries & Herbs. Indeed, our most popular Rejuvenate! superfoods are the ones we developed after our original Rejuvenate! formula, which we often refer to as “Rejuvenate! original greens” as a testament to the high levels of greens (like chlorella) it provides.

HPDI’s bestselling superfoods are Rejuvenate! PLUS (our lighter, sweet greens formula) with greens at a less intense level and Rejuvenate! Berries & Herbs with no greens (but still offering therapeutic levels of dietary RNA). We are pleased our customers love the two newest Rejuvenate! high-RNA formulas. Indeed, that is precisely the reason we developed them – for great taste – and to offer more choice by offering both a lighter green superfood and a berry superfood without any greens.

Given the choice of three unique Rejuvenate! superfoods, why choose Rejuvenate! (original greens)? What are its benefits? What advantages are afforded by this intensely green superfood compared with our lighter, sweeter green version and our delicious berry variant? I’ll attempt to answer these questions and offer insights into the unique benefits of our original high-RNA superfood formula.

rejuvenate original greens high-RNA superfood dietary nucleic acids hank liers PhD

Rejuvenate! (original greens) is formulated by Hank Liers, PhD.

WHAT MAKES “ORIGINAL” REJUVENATE! DIFFERENT?

Rejuvenate! original sells well and remains quite popular. But its demographic is different. People who love original Rejuvenate! tend to be our most health conscious customers. They might be called “health foodies.” We love these folks. Some might even call them “health nuts” which I take to describe them in the best sense of the term. In fact, I count myself among them. Such persons don’t mind (or actually crave) intense greens. They create ways to make greens pleasingly palatable by mixing original Rejuvenate! into smoothies, blender drinks, and concoctions like “Rejuvenate! Lemonade.”

Rejuvenate! original might strike some individuals’ taste buds as “hard core” nutrition best suited for the “granola crunchy” or “wheatgrass” crowd. Or perhaps ideal for those high-minded about vegetable juices, or no-nonsense about having “therapeutic” nutrients in their superfoods. A mindset favoring high-purity, high-density, high-potency and/or high-RNA in superfoods. All this may be true.

What gets lost in any attempt to put Rejuvenate! original into “health food” cubbyhole is the true identity of a powerful healing elixir that can transform health in ways undreamed by the average superfoods aficionado. That in fact, could transform not only the health, but also the very being of anyone who regularly uses it. Not just so-called power users or superfood “snobs,” but ANYONE.

However, you must first understand it. A deeper grasp of the potential life-changing aspects of this über-potent, high-RNA superfood may be your game changer. Or maybe that’s what gets you past your jilted tastebuds to the next level of nutritional adventuresome-ness. Or has you getting creative in the kitchen making smoothies the way you like them.

Some people, of course, don’t want to “think different” or try new things, especially dark green superfoods like Rejuvenate!™. It’s just not in their genes, they say. One problem with such logic is that if you’re already using Rejuvenate! superfoods (like PLUS or Berries & Herbs), then already you’re thinking different. So you may as well give original Rejuvenate! a try.

But seriously. If you are truly interested in optimal health and haven’t yet come to acquire an appreciation for Rejuvenate! the original, best-ever, high-RNA superfood, then read on.

BENEFITS UNIQUE TO REJUVENATE!™ ORIGINAL HIGH-RNA SUPERFOOD

Some benefits up front. There are many elements unique to our original high-RNA superfood formula, and I will talk about them throughout this article. For now, a few important benefits compared to other Rejuvenate! superfoods include 1) greater amounts of dietary nucleic acids per unit weight (i.e., greater nucleic acid density), 2) smaller serving size (which relates to greater RNA density), 3) lower cost per serving, 4) more servings per container (actually 42!!), and 5) overall lower cost per serving (given the fact that all Rejuvenate! formulas provide approximately the same amount of dietary RNA per serving). That’s just for starters.

If these benefits don’t shiver your timbers, then read on. Many customers favor original Rejuvenate!™ for back-to-basics economic value, especially given that Rejuvenate! superfoods are sometimes considered high-end items (even if we don’t routinely think of them that way because they are foundational supplements).

In all fairness, Rejuvenate! original does NOT provide a built-in multivitamin or any added protein. Nor does it contain some of the fancier (if you will) vegetable-based antioxidant formulas and sub-formula ingredients that characterize (or even define) Rejuvenate! PLUS and especially Berries & Herbs with its truly one-of-a-kind cell-protective sub-formula offering both major cell protection and significant antioxidant power (i.e., high ORAC value).

Truly, HPDI formulated every Rejuvenate! high-RNA superfood to provide its own distinct benefits. That is, each formula has its own character and best uses. You can learn more about these differences by consulting our Rejuvenate! Product Comparison.

All Rejuvenate! superfoods provide therapeutic levels of dietary nucleic acids (i.e., that’s what makes them high-RNA formulas) and various levels of protein (from different sources like rice or chlorella). But the fundamental uniqueness of each formula makes each one quite distinct from the others. Of course, I will focus here on what makes Rejuvenate! original so special.

REDISCOVERING AN ORIGINAL REJUVENATE! WRITEUP

I recently came across a writeup about Rejuvenate!™ I posted on the HPDI website when we launched original Rejuvenate! superfood (about 2007). After re-reading it, I recall how excited we were to launch our original formula. Indeed, it was our first superfood product based on our new understanding of how high-RNA superfoods build, support, and maintain optimal health.

It was a heady time!! Since then we’ve launched those two other major Rejuvenate! superfoods, and witnessed the growth of the entire Rejuvenate! line. Since then, I have written extensively on the benefits of dietary nucleic acids, high-RNA foods and superfoods, and all Rejuvenate! superfoods themselves.

What strikes me about my original writeup was how much information it contained that I have not conveyed in the same in more recent posts. Also, it was a promotional writeup, which wasn’t exactly blog material. But I’m going present it here in hopes it sheds light on Rejuvenate! original greens, and on the entire Rejuvenate! line of high-RNA superfoods as they have since developed from the original formula.

I have revised the writeup and brought it up-to-date. It’s an edited version, but I’ve left it mostly as it was always. That is, informative, fact-based, and decidedly oriented toward presenting the many benefits of original Rejuvenate!™, the first high-RNA superfood formulated primarily for the purpose of providing dietary nucleic acids for optimal health, healing, recovery, performance, and overall well-being. My writeup also presents the benefits of consuming dietary nucleic acids in general, which means it’s educational in a broader sense. I hope you enjoy reading it!!

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DISCOVER THE ORIGINAL, HIGH-RNA SUPERFOOD!

NUTRITIOUS & DELICIOUS SUPERFOOD FORMULA!
LEVERAGES DIETARY NUCLEIC ACIDS FOR HEALTH!!

 A NUTRITION REVOLUTION IS HERE.

Legend has it that in 1531, the Spanish explorer Ponce de León searched the New World for the “fountain of youth.” Although he never found the mythical spring, such legends abound throughout history. Descriptions of plants or elixirs restoring youth and health trace back at least 4,000 years to the ancient Sumerian Epic of Gilgamesh. The hero-king Gilgamesh retrieves the plant of everlasting life from the bottom of the sea. In the West, references to the water of life occur in 3rd-century romances celebrating the exploits of Alexander the Great. They all should’ve tried Rejuvenate!™.

REJUVENATE!™ HARNESSES NUCLEIC ACIDS FOR HEALING

While historical references and legends describing plants, foods, or elixirs that restore youth may seem outlandish, does any nutrient exist that could inspire such legends? Certainly, there are many foods that generate dietary accolades from everyone from nutritionists to Hollywood stars. Everything from carrot juice to cayenne pepper is described as having powerful healing abilities. Indeed, many natural foods and substances offer incredible healing potential. Rejuvenate!™ is different. This difference will transform you. No doubt about it.

If there were nutrients that could be said to provide the greatest of benefits for rejuvenating the body, then dietary nucleic acids and their subcomponent nucleotides and nucleosides are legitimate contenders for that title. Nucleic acid nutrition and therapy offers truly remarkable results. The most common dietary nucleic acids are DNA (deoxyribonucleic acid) and RNA (ribonucleic acid). Rejuvenate!™ is a one-of-a-kind high-RNA formula specially designed to maximize the restorative and rejuvenative powers of nucleic acids, especially RNA.

Imagine providing nutritional support to your body for combating the aging process, creating an abundance of energy, and feeling a resurgent zest for life. Rejuvenate!™ can do that for you, and much more. Increased energy and vitality, improved endurance, more lung power, smoother skin, brighter complexion, stronger muscles, and a greater sense of well-being. These are just some of the results reported in research studies and by individuals who consume the nucleic acids contained in Rejuvenate! superfood. We are so sure you’ll be pleased at the effectiveness of our new synergistic, high-RNA nucleic acid superfood. We guarantee it.

BENEFICIAL EFFECTS OF DIETARY NUCLEIC ACIDS

• GREATER ENERGY AND VITALITY

• INCREASED STRENGTH AND ENDURANCE

• IMPROVED LUNG CAPACITY / EASIER BREATHING

• POSITIVE CARDIOVASCULAR EFFECTS

• SMOOTHER SKIN

• MORE YOUTHFUL APPEARANCE

• RAPID HEALING

• GREATER SENSE OF WELL BEING

• REGENERATION AND RESTORATION

(Source: Nucleic Acid Nutrition 116–117)

The beneficial effects of nucleic acids begin immediately and become increasingly noticeable within weeks. Continuous improvements generally are seen and felt thereafter over the course of weeks and months.

Rejuvenate! leverages the power of RNA and other nucleic acids to bring you these benefits in a radically different superfood formula. Rejuvenate! incorporates a variety of high-RNA superfoods, a broad spectrum of nucleic acids, and supporting nutrients. These ingredients act synergistically allowing the formula to maximize nucleic acids’ natural capacity to boost vitality and energy, as well as support processes of rejuvenation and regeneration in the body.

Rejuvenate!™ is formulated by Dr. Hank Liers of Health Products Distributors, Inc. (HPDI). HPDI leverages substantial scientific and technical expertise, and more than 20 years of supplement design experience in bringing you Rejuvenate! high-RNA superfood. You can trust that it’s the most effective nucleic acid supplement ever formulated!

swim lung capacity anti anoxic high-RNA superfoods rejuvenate athletic performance benefits

Dietary nucleic acids exert anti-anoxic effects, boosting oxygen levels in cells.

A HIGH-RNA SUPERFOOD MADE FROM SUPERFOODS

Rejuvenate!™ (original greens) is a high-RNA superfood made from superfoods. Because it contains carefully selected superfoods proven to provide nutrition and high levels of nucleic acids. Rejuvenate! includes chlorella, d-ribose, nutritional yeast, chia seeds, rice bran solubles, spirulina, Vitamin C, chlorella growth factor (CGF), magnesium, dulse, kelp, yeast RNA, folinic acid, and methylcobalamin (Vitamin B12). These high-RNA superfoods and supporting nutrients act synergistically supporting your body’s innate capacities to rejuvenate, restore, revitalize, energize, build, and heal. It also improves athletic performance.

Here are things to know about Rejuvenate!™ :

  • REJUVENATE!™ is a synergistic, high-RNA superfood supplying the important nucleic acids RNA and DNA, as well as key superfoods and nutrients that allow the body to build and utilize nucleic acids.
  • REJUVENATE!™ is remarkably effective because it is designed to provide nutrients that support regeneration, repair, growth, and healing processes in the body. It offers extremely high nutrient density; vitalizing nutrients (e.g., nucleic acids); and synergy afforded by combining these ingredients in a single formula.
  • High-RNA foods in REJUVENATE!™ include chlorella (Chlorella pyrenoidosa), chlorella growth factor (CGF), nutritional yeast, and RNA extracts of nutritional yeast (yeast RNA). These are simply the highest-quality, highest-density sources of nucleic acids available. We provide the purest nucleic acids.
  • Chlorella offers the highest levels of nucleic acids (RNA and DNA) among foods. Chlorella is a superfood all by itself. In addition, it also contains high levels of chlorophyll, a known cleanser, detoxifier, deodorizer, and healer.
  • REJUVENATE!™ provides the unique nucleotide-peptide complex known as Chlorella Growth Factor (CGF) (approximately 5%), further boosting its nucleic acid content. CGF is the high-RNA, nucleic-acid-rich fraction of chlorella. There’s nothing else quite like it for boosting nucleic acid levels in the body.
  • Nutritional yeast contains a relatively high percentage of RNA (approximately 6%), as well as other nutrients. The RNA extracts of nutritional yeast in REJUVENATE!™ provide an additional source of high-quality RNA.
  • REJUVENATE!™ provides other nutritious foods, including spirulina, rice bran solubles, chia seeds, organic kelp, and organic dulse.
  • Chia seeds are an amazing superfood high in essential fats (balanced omega-3 and omega-6), protein, vitamins, minerals, soluble fiber, and antioxidants. Chia is an incredible food providing sustained energy for vibrant living.
  • Vitamins, minerals, and cofactors in REJUVENATE!™ include d-ribose, magnesium (malate and ascorbate), Vitamin C, calcium folinate, and Vitamin B12 (the coenzyme methylcobalamin form).
  • REJUVENATE™ is most effective when combined with a balanced diet, exercise, and intake of foundational supplements (a multivitaminessential fats, and an antioxidant / Vitamin C formula).
  • REJUVENATE!™ contains no additives, excipients, fillers, binders, flow agents, preservatives, colorings, or artificial flavorings.
  • REJUVENATE!™ is powdered for easy mixing with others powders, liquids, or foods. Packed in sturdy white plastic tubs. 100% recyclable.
  • REJUVENATE!™ is tasty in water, juices, smoothies, nut or grain beverages, and blender drinks. It is also wonderful when added to foods, including salads, fruits, soups, sandwiches, wraps, stir-fries, baked goods, etc. Use your imagination!!
Rejuvenate high-RNA Superfood dietary nucleic acids fred liers

Rejuvenate!™ is the original high-RNA superfood.

HIGH-RNA, NUCLEIC ACID NUTRITION

The dietary nucleic acids in high-RNA original Rejuvenate! are natural (i.e., not synthetic or genetically engineered) and are naturally found in foods. Foods containing high levels of what are known to scientists as “purines” usually also contain high levels of nucleic acids. These foods include fish, organ meats (like liver), and certain vegetables (such as beans).

High-RNA foods include superfoods such as chlorella, spirulina, and nutritional yeast. Rejuvenate!™ is formulated to supplement a nutritious diet with high-quality nucleic acids from a variety of food sources, as well as provide nutrients supporting the body’s uptake, assimilation, and use of nucleic acids.

Studies prove the rejuvenating and restorative effects of dietary nucleic acids. Dr. Benjamin S. Frank’s bestselling Dr. Frank’s No-Aging Diet: Eat and Grow Younger (1976) documented his experience with thousands of patients, who experienced rejuvenated appearance (including smoother skin, brighter eyes), greater strength, increased lung power (and improved breathing), more endurance, and greater ability to tolerate temperature extremes (e.g., resistance to cold).

In Nucleic Acid Nutrition and Therapy (1977), Dr. Frank was the first scientist to propose that exogenous nucleic acids (i.e., nucleic acids provided through diet or nutritional supplements) are actually “essential nutrients” similar to vitamins and minerals. He based this proposal on his long-term observations that very great health benefits were obtained by patients consuming nucleic acids at higher levels than could readily be synthesized in the human body.

Dr. Frank found the benefits patients obtained at higher levels far exceeded the benefits he witnessed in controls or in individuals consuming typical “modern” diets. He observed that modern diets lack nucleic acids due to processing, increased intake of  “fast foods,” and declining consumption of traditional food sources of nucleic acids like organ meats and certain vegetables.

Dr. Frank based his dietary recommendations on fish consumption (especially sardines) which contain the highest levels of nucleic acids among animal foods, and to a lesser extent on beans and certain vegetables. In contrast, Dr. Bernard Jensen built upon Dr. Frank’s work on dietary nucleic acids by expanding our understanding of the single-cell aquatic plant chlorella, which contains the highest levels of nucleic acids among all foods.

Dr. Jensen’s Chlorella: Gem of the Orient (1987) firmly establishes the critical role of nucleic acids in nutrition, and represents his best effort to educate people regarding the primary role nucleic acids play in health, healing, rejuvenation, and longevity. Dr. Jensen investigated the dietary role of chlorella in Eastern cultures including Japan and China, where millions of individuals consume chlorella daily because it is revered as a vitalizing, healing superfood.

WHAT ARE NUCLEIC ACIDS?

INTRODUCING NUCLEIC ACIDS, NUCLEOTIDES, AND NUCLEOSIDES

Nucleic acids are complex, high-molecular-weight, biochemical macromolecules composed of nucleotide chains conveying genetic information. They are involved in many bodily processes, especially energy production and communication within cells (i.e., they enable cells to use energy effectively for greater health). In the cell nucleus, RNA carries out instructions coded in DNA—instructions containing information critical for cell structure and function—which are essential for the very lives of our cells, and thereby for our lives.

When cells receive proper directions and energy to carry them out, they keep us youthful. They truly are today’s “fountain of youth.” Dietary or “exogenous” nucleic acids enable you to increase nucleic acid intake to levels that provide therapeutic benefits. Dr. Frank proposed that nucleic acids are essential nutrients. If this is the case, then receiving and maintaining adequate levels of nucleic acids is very important for the body.

Biochemically, nucleic acids are constructed of three of more nucleotides, which are monomers consisting of three components: a heterocyclic base (either a purine or a pyrimidine), a pentose (i.e., five-carbon) sugar (either ribose or deoxyribose), and a phosphate group.

Nucleotides are the structural units of DNA and RNA, as well as the cofactors coenzyme A (CoA), flavin adenine dinucleotide (FAD), flavin mononucleotide (FMN), nicotinamide adenine dinucleotide (NAD+), and nicotinamide adenine dinucleotide phosphate (NADP+). Many of these cofactors are used in glycolosis for generating ATP (as part of anaerobic respiration). They are also used in the Krebs cycle (or citric acid cycle), which in aerobic organisms (including humans) is part of a metabolic pathway involved in the conversion of nutrients (proteins, carbohydrates, and fats) into energy (ATP) through a process of cellular respiration. Other coenzymes are involved in the pentose phosphate pathway (HMP shunt) and required for the biosynthesis 5-carbon sugars (e.g., d-ribose) and nucleic acids.

Nucleosides are glycosylamines created by the attachment of a nucleobase to a ribose or deoxyribose ring. Some nucleotides are cytidine, uridine, adenosine, guanosine, thymidine, and inosine. Nucleosides may be phosphorylated by certain kinases within cells, producing nucleotides (i.e., the molecular building blocks of DNA and RNA, as described above). Enzymes known as nucleotidases break down nucleotides into nucleosides (and phosphate).

High-RNA Rejuvenate!™ incorporates the science behind nucleic acids and puts them to work for you. The healing and rejuvenating capabilities of nucleic acids largely derive from the essential role they play in the production of energy in the body, and other critical functions. When you obtain enough of the right kinds of nucleic acids, your body produces the energy required for its optimal function. Dr. Hank Liers specifically formulated high-RNA Rejuvenate!™ superfood to give you those nucleic acids, so you can function at your best.

Learn more about Rejuvenate! (original greens), HPDI’s original high-RNA superfood formulated by Dr. Hank Liers.

HIGH-RNA SUPERFOODS ARE THE FUTURE OF NUTRITION

Nucleic acids are involved in many bodily functions, including energy production and communication within cells (i.e., they enable cells to use energy effectively for greater health). In the cell nucleus, RNA carries out instructions coded in DNA—instructions containing information critical for cell structure and function—which are essential for the very lives of our cells, and thereby for our lives. When our cells receive proper directions and energy to carry them out, they keep us youthful. They truly are the body’s own “fountain of youth.” Rejuvenate!™ is designed to build upon current knowledge regarding nucleic acids in order to help support the body’s efforts in rebuilding, restoring, and revitalizing itself.

Many traditional foods contain nucleic acids, and dietary and other exogenous nucleic acids (e.g., RNA extracts) have been used therapeutically for more than 30 years. Now the therapeutic use of dietary nucleic acids is here to stay. And Rejuvenate! original is the formula that best leverages dietary nucleic acids into an ultra-functional superfood.

Rejuvenate! is designed to provide high levels of nucleic acids, including RNA, DNA, nucleotides, and nucleosides. Modern diets are deficient in nucleic acids. While food sources of nucleic acids include certain fish, organ meats, beans, yeast, and various food algae, dietary nucleic acid intake has dramatically declined in recent years.

Declines in dietary nucleic acid consumption relates to various factors and practices related to industrial agriculture, modern food processing, as well as fast food diets and diets that may be more subtly deficient in nutrients. Rejuvenate! high-RNA superfood provides therapeutic amounts of nucleic acids and other nutrients that help address deficiencies, and give the body nutrients necessary for creating health and vitality.

BACKGROUND TO NUCLEIC ACID NUTRITION & THERAPY

Dr. Benjamin S. Frank’s Dr. Frank’s No-Aging Diet: Eat and Grow Younger (1976) was a bestseller that sold millions of copies. Dr. Frank’s book increased scientific and popular interest in fish as a rich source of dietary nucleic acids. Current popularity of fish and seafood consumption reflects increased awareness of nucleic acids as demonstrated in Dr. Frank’s books and research studies.

Following Dr. Frank’s research studies, Dr. Bernard Jensen helped thousands of his patients recover their health using nucleic acid therapy. In particular, Dr. Jensen dramatically raised awareness of the healing powers of nucleic acids through his publications, including Chlorella: Gem of the Orient (1987).

Dr. Frank and Dr. Jensen were ahead of their time in advancing practical applications of nucleic acid nutrition and therapy. While they did not stand alone in their efforts to promote nucleic acids for health and healing, no one has since publicized these benefits as effectively as they did. They were pioneers who helped establish the importance of nucleic acids. Their messages about nucleic acids must be shared, disseminated, and broadly applied to human nutrition.

rejuvenate high-RNA superfood chlorella gem orient bernard jensen fred liers hpdi integratedhealth

Dr. Bernard Jensen’s 1987 classic on chlorella as a high-RNA therapeutic food.

The purveyors of high-RNA foods such as nutritional yeast (e.g., Red Star’s Vegetarian Support Formula) typically emphasize the presence of nutritional factors other than nucleic acids, such as the B vitamins (especially B12). For example, nutritional yeast contains approximately 6% RNA, which is relatively large amount. Certain high-RNA food products like Marmite (consumed extensively in England for a century) and the well-known Vegemite (popular in Australia) are marketed or promoted as rich in B vitamins, yet a great deal of their nutritional benefits derive from their nucleic acid content. (Note: B vitamins are valuable because they work powerfully with nucleic acids to make them more effective.)

MILESTONES IN NUCLEIC ACID NUTRITION AND THERAPY

• STANFORD RESEARCH INSTITUTE FOOD STUDY (1948)

• DISCOVERY OF CHLORELLA GROWTH FACTOR (c. 1950) 

• CRICK, WATSON, AND WILKINS WIN NOBEL PRIZE (1962)

• DR. BENJAMIN S. FRANK’S NO-AGING DIET (1976)

• DR. BERNARD JENSEN’S CHLORELLA: GEM OF THE ORIENT (1987)

• REJUVENATE!™ (original greens) (2007)

 • REJUVENATE!™ PLUS (2009) 

• REJUVENATE!™ BERRIES & HERBS (2010)

Certainly it is easier to consume foods like fish, beans, nutritional yeast, and other high-RNA foods, as well as superfoods like chlorella than to comprehend the complex biochemistry of nucleic acids. The good news is that while it is desirable to be as informed as possible about nutrition, you don’t need a degree in molecular biology to experience for yourself the health benefits of nucleic acids. As described above, these outstanding benefits include greater vitality, increased strength and endurance, easier breathing, a more youthful appearance (e.g., smoother skin, fewer wrinkles), rejuvenating effects, and healing and regeneration.

Beyond eating foods high in nucleic acids, consuming Rejuvenate!™ high-RNA superfood allows you to boost your intake of nucleic acids by providing many of these foods in a single, synergistic superfood. Rejuvenate!™ brings powerful nutrition to you in a convenient, tasty powder that mixes easily into water, blender drinks, juices, smoothies, bars, nut buttters, salads, soups, teas, etc. Your use of it is limited only by your imagination!!

APPLIED NUCLEIC ACID NUTRITION

Dr. Frank pioneered the use of dietary nucleic acids in the 1960s and 1970s. Other scientists and nutritionists have grasped the significance of his work for human health and well-being. In 1962, Drs. Watson, Crick, and Wilkins won the Nobel Prize in Medicine for discoveries regarding the molecular structure of nucleic acids (and its significance for information transfer in living material), including determining the structure of DNA. Since then science has greatly expanded our knowledge about DNA, RNA, and other nucleic acids.

Yet, it is notable that in our era of amazing advances in the biological sciences, little has been done to integrate advances in genetic science with what Dr. Frank and others have shown to be true regarding nucleic acids (e.g., RNA and DNA) and high-RNA foods for nutrition and therapy. We now have the knowledge to integrate the theoretical understanding of dietary nucleic acids with their practical applications based on their proven benefits to human health. Rejuvenate!™ high-RNA superfood is designed for this purpose. That is, to help you create optimal health!

DIETARY NUCLEIC ACIDS ARE FOR EVERYONE, INCLUDING YOU!!

Which brings us back to Gilgamesh and legendary sources of youthfulness. Unlike the time of Gilgamesh, Alexander the Great, or even Ponce de León, there exists today the knowledge of nucleic acids (RNA, DNA, nucleotides, nucleosides, etc.) as powerful means for supporting rejuvenation, healing, vitality, and health. The knowledge that nucleic acids can be considered modern-day fountains of youth. That you can benefit from them today, not tomorrow, and you can do it more easily (and naturally) than you ever imagined! You will be amazed by the results.

Despite recent advances in nutritional science, few people truly comprehend the power of dietary nucleic acids and high-RNA superfoods for optimal health, healing, and things like athletic performance. But you can benefit starting now!

HPD leverages its considerable scientific expertise and more than 20 years of supplement design experience to bring you the power of dietary nucleic acids in a one-of-a-kind, high-RNA superfood. Rejuvenate!™ original represents the most effective RNA supplement formula ever designed!! Try our high-RNA superfood today to leverage the power of nucleic acids for your own health and well-being!!

DON’T MISS THE NUTRITION REVOLUTION. EXPERIENCE REJUVENATE!™.

HPDI offers you Rejuvenate!™ as the first and only dedicated, high-RNA superfood ever formulated. We applied the knowledge gleaned from the works of nucleic acid pioneers Dr. Benjamin S. Frank and Dr. Bernard Jensen. We now celebrate the launch of our Rejuvenate™ high-RNA superfood and make it available to health enthusiasts like you. This is the superfood for which you have been waiting!

We offer Rejuvenate!™ in 500 gram (1.1 lb) recyclable white plastic tubs. At 42 servings per tub (a full six week’s supply!!), there’s plenty in a single tub to see what it can do for you. Most people experience noticeable results in three weeks or less (and usually come back for more). See for yourself the benefits you can experience from our super, high-RNA formula. We guarantee it.

For fastest orders, order online. If you prefer, call toll-free 1-800-228-4265. We accept all credit cards, Paypal, personal checks, and money orders. Your order will be processed immediately.

We enjoy Rejuvenate™ and we’ve seen what it does for our health. We’re absolutely sure you’ll enjoy it and gain health benefits, too. Get started now to begin your journey into greater health!

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FINAL CONSIDERATIONS

Since I wrote the original writeup (above), we’ve launched two additional Rejuvenate! superfoods, Rejuvenate! PLUS and Rejuvenate! Berries & Herbs. Everyone has a favorite Rejuvenate! superfood, and some people enjoy mixing them. For example, Rejuvenate!™ (original greens) mixed with Rejuvenate! Berries & Herbs is a winning combination we often hear about from customers (and use ourselves!!). Mixing original Rejuvenate! with other Rejuvenate superfoods is a viable option because original provides the most RNA for the least cost and the offers the highest levels of greens, which support optimal health.

All three Rejuvenate high-RNA superfoods dietary nucleic acids

Rejuvenate! superfoods offer high-RNA nutrition for optimal health.

Whatever your personal taste, consider keeping some Rejuvenate! original around to maximize your intake of dietary nucleic acids and greens. Mix and match with other Rejuvenate! superfoods and/or any other favorite ingredients. You’ll gain all the nutritional richness loaded into original Rejuvenate!™ and reap all the proven benefits from high levels of dietary nucleic acids.

ADDITIONAL RESOURCES

Rejuvenate! (original greens) (product page)

Rejuvenate!™ PLUS (product page)

Rejuvenate!™ Berries & Herbs (product page)

Rejuvenate!™ Superfoods Side-by-Side Comparison

FROM THE HPDI BLOG

Rejuvenate! Lemonade – Delicious & Satisfying

High-RNA Rejuvenate! Superfood

Super-Tasty Rejuvenate! Superfood Bars

Get Results with Rejuvenate!™ Superfoods

Dietary RNA for Athletic Performance

9 Things to Know About Rejuvenate! Superfoods

Dietary Nucleic Acids – Dr. Benjamin S. Frank, Part 1

Dietary Nucleic Acids – Benjamin S. Frank, Part 2

Be Healthy with Rejuvenate! Berries & Herbs

Super-Tasty Morning Nutritional Drinks

SOCIAL MEDIA

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