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HYDROGEN SUPPLEMENTS – ACTIVE H2 ULTRA and MEGAHYDRATE

Fred Liers PhD hydrogen supplements Active H2 Ultra MegahydrateSupplemental hydrogen is fast becoming essential in many people’s nutritional supplement regimens. Why? Because hydrogen offers significant health benefits, including excellent antioxidant protection, increased energy, faster recovery, and improved well-being. Who doesn’t want those benefits?

My favorite way to take hydrogen is to make hydrogen-infused water, or what I call a hydrogen “fizzy” drink. Two products I like best are Active H2 Ultra tablets and Megahydrate (available in powder and capsules). Active H2 Ultra provides molecular hydrogen (H2) and Megahydrate provides hydride (H-). Both are great standalone formulas, yet work well together as each provides unique means to quench free radicals effectively.

MAKE “FIZZY” HYDROGEN-INFUSED WATER WITH ACTIVE H2 ULTRA

Drinking H2-rich water is an easy and effective method for obtaining hydrogen, according to the Molecular Hydrogen Foundation. Making hydrogen-infused water is simple and convenient, as you can drink it at home or while traveling. Effective hydrogen products HPDI carries include Active H2 Ultra tablets, Megahydrate powder, and Megahydrate capsules.

My favorite hydrogen drink contains both Active H2 Ultra and Megahydrate. I take these products separately at times, but find it easier to take them together—and gain the benefits of both immediately.

Active H2 Ultra Megahydrate

Active H2 Ultra tablets and Megahydrate powder work together for major antioxidant power.

INGREDIENTS – HYDROGEN-INFUSED WATER

• 1 Scoop Megahydrate powder (500 mg) or 1 Megahydrate capsule (600 mg)

• 1 Tablet of Active H2 Ultra

• 8–16 Ounces of Purified Water

DIRECTIONS: Put one scoop of Megahydrate powder (or open one capsule) into your container of water. Let sit for about 30–60 seconds. Drop in one Active H2 Ultra tablet. Allow it to effervesce for one minute or until fully dissolved. Drink immediately. For best assimilation, preferably take on an empty stomach at least 10–15 minutes before food. Wait one hour after eating to drink hydrogen-infused water.

Note: Do not wait long after effervesce stops to drink the water because hydrogen will escape into the air. Alternatively you can cap the container with a lid, and this will allow the hydrogen to last a while longer.

Molecular hydrogen is sufficiently small to pass through glass, so use a metal container if you plan to cap it. If you drink immediately, then the type container you use won’t matter. I personally prefer a glass mason jar. This allows me to see the tablet dissolve, but also means drinking it immediately.

I make 1–3 hydrogen fizzy drinks daily, first in the morning and then in the afternoon, but almost never in the evening as it can be energizing. I drink hydrogen water on an empty stomach. I gain a significant energy boost, but also other benefits, including improved athletic performance, faster recovery from exercise, and an overall greater sense of well-being.

I highly recommend you try hydrogen supplements for yourself, and then consider them for your clients or patients. Our experience is that most people are pleasantly surprised by the results they get from hydrogen supplements, especially if they have a need for exceptional free-radical defense, or stand to benefit from the proven effects of hydrogen (see list below).

You will want to continue taking hydrogen supplements regularly because the benefits are so significant, especially over time. Let the power of hydrogen starting working for you.

Active H2 Ultra is a fast-effervescing tablet.

MOLECULAR HYDROGEN BACKGROUND

More than 1,000 scientific studies indicate molecular hydrogen offers therapeutic potential in 170 disease models, and every organ of the body, according to the Molecular Hydrogen Institute.

Hydrogen is an antioxidant. It is also an extremely small molecule that can penetrate even the tiniest cellular compartments. This helps explain how hydrogen works to offer free-radical defense throughout the entire body.

The medical and scientific literature is clear. Hydrogen’s modes of action:

H2 reduces oxidative stress as a selective antioxidant and by maintaining homeostatic levels of glutathione, superoxide dismutase, catalase, etc.

H2, like other gaseous signaling molecules (i.e. NO, CO, H2S), appears to have cell signal-modulating activity affording it with anti-inflammatory, anti-obesity, and anti-allergy benefits.

We include hydrogen supplements in HPDI’s system of Foundational Supplements. In fact, hydrogen formulas as just one of six foundational supplements. We consider hydrogen a “secondary” foundational supplement usually to be added to a supplement regimen after the four primary ones: multivitamins, antioxidant & vitamin C formulas, essential fatty acids, and superfoods high in dietary nucleic acids (i.e., Rejuvenate! superfoods).

THERAPEUTIC USES OF HYDROGEN

The scientific literature discusses the use of molecular hydrogen for many clinical applications, including:

• Metabolic Syndrome including diabetes, hyperlipidemia, arteriosclerosis, hypertension, and obesity

• Ischemia/reperfusion injuries, including cerebral and myocardial infarctions, organ transplants, post-cardiac arrest

• Neuroprotection, including applications for dementia, Parkinson’s disease, depression, and anesthesia

• Inflammation, including applications for polymicrobial sepsis, rheumatoid arthritis, wound healing, and bowel diseases

• Mitochondrial diseases

• Hemodialysis and ventilation

• Aging, including cognitive decline

• Exercise, including applications for fatigue, lactic acid, recovery, and oxidative stress related to heavy exercise

Side effects of cancer therapies, including radiotherapy and chemotherapy

• Many other benefits

(Source: Molecular Hydrogen Foundation)

HOW HYDROGEN WORKS

According to the Molecular Hydrogen Foundation, there are three ways molecular hydrogen exerts positive health effects:

1.  Molecular hydrogen easily diffuses into subcellular compartments where it scavenges cytotoxic oxygen radicals, thereby protecting DNA, RNA, and proteins against oxidative stress.

2.  Molecular hydrogen triggers activation or upregulation of additional antioxidant enzymes (e.g., glutathione, superoxide dismutase, catalase, and others) and/or cytoprotective proteins of the body.

3.  Molecular hydrogen may be a novel signaling molecule that alters cell signaling, cell metabolism, and gene expression. This may explain its apparent anti-inflammatory, anti-allergic, and anti-apoptotic (or anti-cell death) effects.

Notably, two of these three mechanisms of action involve antioxidant activity. Hydrogen is one of the best antioxidants for all the reasons discussed, and we believe it acts synergistically with other antioxidants, including Vitamin C, glutathione, and Nrf2 activators (like those in HPDI’s Ultimate Protector).

MEGAHYDRATE MAKES MOLECULAR HYDROGEN BETTER

Why add Megahydrate to your hydrogen-infused water? Because Megahydrate provides hydride, the negative anion of hydrogen, or H-. Thus, a tiny scoop of Megahydrate provides vast quantities of electrons available to quench free radicals. Unlike molecular hydrogen, which dissipates quickly into the air, and therefore must be consumed immediately, hydride rich water (about -700 ORP!) may last for three weeks in an active state. That is a good reason to take Megahydrate by itself whether or not you already use it with molecular hydrogen in your hydrogen “fizzy” drink (see recipe above).

Megahydrate Active H2 Ultra

Megahydrate (powder or capsule) provides hydride (H-) for free radical defense.

The interesting thing about H- is that after it gives up its electron, it becomes simply “H” or atomic hydrogen. It then looks to pair up with another “H” to become H2, which is molecular hydrogen. In this way, Megahydrate not only gives you large quantities of stable H- and potent antioxidant capabilities, but also then creates molecular hydrogen in your body. This means it becomes a different kind of antioxidant, H2, which is therapeutic in itself.

By adding Megahydrate to your hydrogen-infused water (as described above), you create a unique “double whammy” drink in which you maximize the powers of hydrogen (H2 and H-) to create and maintain good health.

Note: Megahydrate powder is more cost effective than Megahydrate capsules, which must be opened into the fizzy drink. However, Megahydrate capsules are convenient for traveling and are easy to take by themselves. I keep both available, so I can use either one depending on my daily needs.

hydrogen supplements active h2 ultra

DRINKING HYDROGEN-INFUSED WATER

Drinking H2-rich water is an easy, effective method for obtaining hydrogen according to the Molecular Hydrogen Foundation. Drinking hydrogen-infused water is convenient as you can drink it at home or while traveling. Effective hydrogen products HPDI carries include Active H2 Ultra tabletsMegahydrate capsules, and Megahydrate powder.

As noted, I make 1–3 hydrogen drinks daily using Megahydrate and Active H2 Ultra. I drink them on an empty stomach. I enjoy a significant energy boost, which helps power me through my day. I gain other benefits, including improved athletic performance, noticeably faster recovery from exercise, and an overall greater sense of well-being.

The nice thing about hydrogen supplements is how flexibly you can use them. While I typically prefer to make hydrogen-infused “fizzy” drinks in water, I will often sip Megahydrate-infused water by itself during the day or even in the evening (as it is less energizing than molecular hydrogen).

Megahydrate does not immediately lose its potency in water, so it can be casually sipped. Also, if you’re traveling or on-the-go, you can simply swallow a Megahydrate capsule by itself. Finally, you can carry Active H2 Ultra tablets with you wherever you go, and add them to water whenever convenient for you.

http://www.integratedhealth.com/supplements/hydrogen-products.html

Megahydrate and Active H2 Ultra creates an ultra-healthy hydrogen fizzy drink.

TRY HYDROGEN!

Try hydrogen supplements for yourself. Then consider recommending them to client, patients, friends, and family. Most people welcome the results from hydrogen. This is especially true if they need exceptional free-radical defense — and who doesn’t? We can all stand to benefit from the proven health benefits hydrogen uniquely provides.

After you try hydrogen, you will want to continue taking it. Hydrogen-infused “fizzy” water can become your go-to drink. Remember, hydrogen works best when taken consistently and daily!

 

HYDROGEN RESOURCES

Hydrogen Articles

Hydrogen Supplements – Make Hydrogen Drinks

Hydrogen for Optimal Health

Wonders of Molecular Hydrogen

Molecular Hydrogen (H2) at the Forefront of Health Research

The Science Behind MegaHydrate by Hank Liers, PhD

Hydrogen Supplements

Active H2 Ultra tablets

Megahydrate capsules

Megahydrate powder

HPDI hydrogen products

Other Hydrogen Resources

Molecular Hydrogen Foundation

hydrogen supplements megahydrate active H2

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DAILY ROUTINE FOR NUTRITIONAL SUPPLEMENTS

Fred Liers PhD nutritional supplements tips tricks daily routineToday I’m sharing my strategies for taking nutritional supplements in an easy,  organized way, and helping ensure you take them daily. I don’t like the word “compliance” because it implies doctor’s orders. Consider my ideas “hacks” instead, for establishing a daily routine.

My goal is making your daily supplement routine simpler. That is, a hassle free, “no brainer” routine that guarantees you take the vitamins, minerals, essential fats, and other supplements you need. At least the most important ones.

YOU NEED A DAILY ROUTINE

Getting out of the house with a good breakfast is hard enough. Nutritional supplements have a way of being forgotten first. That is, unless and until you have a system: a set of strategies for success to ensure a daily routine.

I’ve been working on my “system” for 30 years. It works for me and many others I’ve shared it with. So I’m sharing it with you. But you don’t need to adopt my system or strategies. Watch the video, take what you like, and make it your own. Craft a system that works for you.

My idea is to inspire and show you it’s possible to dummy proof your supplement regimen to never “miss a dose”—or almost never. No matter how busy you are, how rushed you feel, or how often you tend to forget things. You can do this.

FRED’S SYSTEM FOR A SUCCESSFUL DAILY SUPPLEMENT ROUTINE

1. VISIBILITY IS EVERYTHING: “WHAT YOU SEE IS WHAT YOU TAKE”

One of the most important things to consider when establishing or creating a regimen for taking supplements is to make sure your supplements are visible. That is, not hidden in a place that allows you to forget to take them. Like the bathroom. Or your garage. Bad places for supplements in general, unless you’re storing them for future use, or want them to expire.

Making your supplements visible means putting them in a place where  you can see them. Get them out of your bathroom or closet and put them in your kitchen area where you will remember to take them. Recall that nutritional supplements are “food supplements,” right?

The kitchen is best for ensuring you take your supplements. If your kitchen can’t be home to your supplements, then other visible places might include the dining area (or where you eat) or possibly your pantry (or where you keep foods). The top of the refrigerator is surely an unused shelf space you cannot miss.

Another option is keeping visible the primary supplements you take, such as multivitamins, Vitamin C, essential fats, or other high-priority supplements. Then keep less important supplements available, but not in a way that clutters counters or other spaces. By prioritizing this way, you at least ensure the visibility of your most important supplements.

The main thing: If you can see your supplements, you are far more likely to take them, and maintain your daily routine. The kitchen is an ideal place. Because if you can’t see them, you won’t take them.

2. ORGANIZE: REFRIGERATOR TOPS ARE GOOD (BUT I REPEAT MYSELF)

After your nutritional supplements are in your kitchen or in an easily accessible—and hopefully prominent place, then consider organizing them. And noted, I often suggest using the top of the refrigerator since they won’t take up counter space, yet remain visible. Other strategies for organizing and saving space are using small shelves or rotating stands, like lazy susans, as shown in the video above. Or a small basket.

If you must put your supplements away, such as inside a cabinet to save space or for aesthetic reasons, then try to use a kitchen cabinet that is central and easily accessible. And if you use a shelf, lazy susan, or basket, then set it up so you can easily reach the shelf or grab the basket.

The main thing: Keep supplements organized for quick and easy access. This smooths the process for actually taking them. You will be glad you did. Your body and mind will thank you.

3. CONTAINERIZE: CUPS & SAUCERS 101

Your supplements are visible and organized. Now what? Containerize.

Containerizing is not just for your basket or shelf of supplements. It is also for your daily doses. That is, I suggest you set your daily doses out in advance when possible. This helps simplify your day. You can “take” your vitamins without having to think too much. You can just “grab and go.”

The system I use—and demonstrate in the video—relies on small pyrex cups. You can also you small bowls or paper cups, or any small containers you like.

I use one cup per dose, and I usually break up my supplements into two doses per day (morning and early evening), so I use two cups per day.

I like pyrex cups because they stack neatly and don’t take up much counter space. They are portable, so you can pick up a cup (one dose) and carry it with you.

After your doses are prepared, set them out in a place where you will see them—like the kitchen counter or dining room table. Somewhere where you are most likely not to forget them.

The main thing: Divide your supplements into daily doses or sub-doses you can take when you’re ready. It’s much easier to take them when your doses are made in advance. You will win medals from the Supplement Compliance Club.

4. BAGS FOR TRAVEL: BAG ‘EM UP!

After your doses are set out for a day or two—or an entire week—they will be ready and waiting for you. For people who work outside the home or who are traveling, transfer your supplements to portable containers. This might be snack bags (as in my video), but it could be a special box or baggie that holds individual doses.

If I plan to travel or leave for work, I often bag my supplements and place them in my suitcase or car the night before. This ensures I don’t forget them.

For travelers in a pinch, you can put all supplements for say, a week, in a single container, and then divide them up daily. That’s not my ideal, but I’ve seen it work for people who won’t containerize every dose before traveling.

The main thing: Scientific studies prove that having your daily supplements pre-bagged improves your chances of taking them by 1000% when traveling. Pre-bagging makes getting your daily dose so easy, you can think about other things, like where you will go next.

MAINTAIN A DAILY ROUTINE

Maintain your supplement routine. Doggedly. A routine can take time to establish. After you get one started, stick to it like a bee on honey.

If you make your supplements visible, then organize, containerize, and bag them for travel, you will never miss a dose. You will guarantee compliance by implementing these simple “hacks.” Then watch as your health improves and you feel better. Like Superman or Superwoman. Be prepared to jump over buildings in a single bound. ~

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HYDROGEN SUPPLEMENTS – MAKE HYDROGEN DRINKS

Fred Liers PhD hydrogen supplements drinks H2I love hydrogen supplements. So should you. Since starting my morning—and often afternoon—routine of making hydrogen drinks in the kitchen, I have come to appreciate the surge of energy lasting many hours, as well as a host of other benefits.

Most of all, I am amazed how easy hydrogen supplements are to use considering how much they do for you, and how well they complement the supplements I already take—seeming to make them all more effective.

I typically use one or two effervescing Active H2 Ultra tablets in 8–16 ounces of water. Then I like to open one Megahydrate capsule directly in the effervescing water. I wait about 90 seconds to let the tablets stop “fizzing” and then I drink immediately. Allowing the drink to sit for a few minutes is okay, but the sooner you drink it, the higher the concentration of hydrogen.

Note: I used Vital Reaction tablets in this video, but my preferred product is the new, improved Active H2 Ultra (tablets) which dissolves in less than one minute—faster than other hydrogen tablet formulas—thereby preserving more hydrogen in the water.

HYDROGEN SUPPLEMENTS ARE EFFECTIVE

Hydrogen supplements are among the newer, cutting-edge nutritional formulas available to support optimal health. More than 500 scientific articles now support the therapeutic potential hydrogen for essentially every organ system and in 150 human disease models, according to the non-profit Molecular Hydrogen Foundation. In fact, hydrogen is rapidly incorporated into medicine, sports medicine, peak performance, elite fitness, and more.

Hydrogen is an antioxidant. It is also an extremely small molecule that can penetrate even the tiniest cellular compartments. This helps explain how hydrogen works to offer free-radical defense throughout the entire body.

The medical and scientific literature is clear. Hydrogen’s modes of action:

  • H2 reduces oxidative stress as a selective antioxidant and by maintaining homeostatic levels of glutathione, superoxide dismutase, catalase, etc.
  • H2, like other gaseous signaling molecules (i.e. NO, CO, H2S), appears to have cell signal-modulating activity affording it with anti-inflammatory, anti-obesity, and anti-allergy benefits.

We include hydrogen supplements in HPDI’s system of Foundational Supplements. In fact, hydrogen formulas as just one of six foundational supplements. We consider hydrogen a “secondary” foundational supplement usually to be added to a supplement regimen after the four primary ones: multivitamins, antioxidant & vitamin C formulas, essential fatty acids, and superfoods high in dietary nucleic acids (i.e., Rejuvenate! superfoods).

HYDROGEN MEDICINE

The scientific literature discusses the use of molecular hydrogen for many clinical applications, including:

• Metabolic Syndrome including diabetes, hyperlipidemia, arteriosclerosis, hypertension, and obesity

• Ischemia/reperfusion injuries, including cerebral and myocardial infarctions, organ transplants, post-cardiac arrest

• Neuroprotection, including applications for dementia, Parkinson’s disease, depression, and anesthesia

• Inflammation, including applications for polymicrobial sepsis, rheumatoid arthritis, wound healing, and bowel diseases

• Mitochondrial diseases

• Hemodialysis and ventilation

• Aging, including cognitive decline

• Exercise, including applications for fatigue, lactic acid, recovery, and oxidative stress related to heavy exercise

Side effects of cancer therapies, including radiotherapy and chemotherapy

• Many other benefits

(Source: Molecular Hydrogen Foundation)

HOW HYDROGEN WORKS

According to the Molecular Hydrogen Foundation, there are three ways molecular hydrogen exerts positive health effects.

1. Molecular hydrogen easily diffuses into subcellular compartments where it scavenges cytotoxic oxygen radicals, thereby protecting DNA, RNA, and proteins against oxidative stress.

2. Molecular hydrogen triggers activation or upregulation of additional antioxidant enzymes (e.g., glutathione, superoxide dismutase, catalase, and others) and/or cytoprotective proteins of the body.

3. Molecular hydrogen may be a novel signaling molecule that alters cell signaling, cell metabolism, and gene expression. This may explain its apparent anti-inflammatory, anti-allergic, and anti-apoptotic (or anti-cell death) effects.

hydrogen supplements Active H2 Ultra tablets

Active H2 Ultra hydrogen supplement (60 tablets).

HYDROGEN IS SAFE

Molecular hydrogen exhibits great safety, and it is regarded as safe for use in the body. It is shown no toxicity even in high concentrations.

Safety standards have long been established for high concentrations of hydrogen for inhalation largely because of the history of high-pressure H2 gas used in deep-water diving gas mixtures for preventing decompression sickness.

Notably, H2 gas combusts only at temperatures higher than 527 °C, and it explodes by chain reaction with oxygen (O2) only in the range of H2 concentration (4–75%, vol/vol).

Molecular hydrogen is used for medical applications safely by several ingestion methods including inhalation of 1–4% hydrogen gas, for example, which exhibits great effectiveness. All these factors mean that hydrogen is safe, easy-to-use, and effective for therapeutic purposes.

DRINKING HYDROGEN-INFUSED WATER

According to the Molecular Hydrogen Foundation, drinking H2-rich water is the easiest, and often the most effective, method for obtaining hydrogen.

Drinking hydrogen-infused water is easy to do, and convenient as you can drink it at home or while traveling. Effective hydrogen products HPDI carries include Active H2 tablets and Megahydrate capsules.

As noted, I make one or two hydrogen drinks daily, first in the morning and then often again in the afternoon. I drink them on an empty stomach. I enjoy a significant energy boost, which helps power me through my day. I gain other benefits, including improved athletic performance, noticeably faster recovery from exercise, and an overall greater sense of well-being.

I highly recommend you try hydrogen supplements for yourself, and then consider them for your clients or patients. Our experience is that most people are pleasantly surprised by the results they get from hydrogen supplements, especially if they have a need for exceptional free-radical defense, or stand to benefit from the proven effects hydrogen uniquely provides (see list above).

Once you try hydrogen, you will want to continue taking it because the benefits are so significant. Let the power of hydrogen starting working for you on a daily basis!

hydrogen supplements Megahydrate

Dr. G. Patrick Flanagan’s Megahydrate (60 capsules).

HYDROGEN RESOURCES

Hydrogen Articles

Hydrogen for Optimal Health

Wonders of Molecular Hydrogen

Molecular Hydrogen (H2) at the Forefront of Health Research

The Science Behind MegaHydrate by Hank Liers, PhD

Hydrogen Products

Active H2 Ultra tablets

Megahydrate capsules

Other Hydrogen Resources

Molecular Hydrogen Foundation

hydrogen supplements megahydrate active H2

Hydrogen supplements like Megahydrate and Active H2 are foundational in the HPDI supplement system.

MULTIVITAMINS – WHY YOU NEED THEM

Fred Liers PhD multivitaminsMultivitamins are the most important of the basic or foundational supplements providing nutrients essential for health and wellness. Because if there is a single nutritional supplement everyone should take, a multivitamin is it.

But it can’t be just any multivitamin. The best multivitamins are complete, high-potency, high-quality, high-purity, provide a complete range of essential vitamins and minerals, and contain advanced forms—more about advanced forms later.

The purpose of taking a high-potency multivitamin not only is to provide the body with amounts and forms of nutrients meeting minimum requirements for avoiding deficiency conditions, but also sufficient levels of nutrients that can support optimal health. Because vitamins levels for optimal health are NOT the same as levels required to avoid deficiency conditions.

MORE THAN DAILY ALLOWANCES

While 40% of Americans say they take a multivitamin daily, how many actually obtain all the nutrients they need for optimal health from taking it? Practically no one. Why?

Because basic “recommended daily amounts” (100% of daily allowance) typically found in multivitamins are based on models for disease prevention. That is, these are minimum levels indicated to avoid conditions like Pellagra (caused by vitamin B3 deficiency), Beriberi (caused by vitamin B1 deficiency), or Rickets (caused by vitamin D deficiency), for example. Nutrient fortification of foods by law has mostly eradicated those conditions. But, as noted, minimum recommended amounts are not the amounts required for optimal health.

The best multivitamin supplements therefore do not provide just 100% of a recommended daily amount of a certain nutrient, but far higher amounts. That is for truly optimal health, high-potency is a must in multivitamins. One of the main reasons for this is “biochemical individuality.” While most people fall within a certain range in terms of their needs for a specific nutrient, the overall range (or bell curve) may be quite large. Your needs may be greater.

Another, related reason is genetics. If you are heterozygous for a gene that requires a specific nutrient, then you may already be at a disadvantage for assimilating or processing it. If you are homozygous, then not having sufficient amounts of a nutrient can have much larger, adverse consequences.

For any given nutrient, then, your needs may be higher or significantly higher than other people’s needs. The best way to guarantee your needs are met is to ensure you consume larger amounts. That is, a high-potency multivitamin providing levels of nutrients well above the minimum amounts established to avoid deficiency.

MULTIVITAMINS ARE SAFE, LOW COST,
AND EFFECTIVE

High-potency multivitamins work well because vitamins—at least at the levels we are talking about here—are non-toxic, safe, and well-tolerated. Add to the safety of vitamins their relatively low cost (especially compared to pharmaceuticals) that solidifies the case for high-potency multivitamins as a virtual “no-brainer” for supporting good health.

That is the basic rationale for why you need a high-quality, high-potency multivitamin. There are many other reasons. Such reasons include the fact that diet alone is usually not enough to provide the levels of basic nutrients you need.

DIET ALONE IS USUALLY INSUFFICIENT FOR OPTIMAL LEVELS OF NUTRIENTS

Diet alone could perhaps be sufficient if foods were nutrient-dense and you consumed enough of them. But foods today are typically not nutrient-dense given how modern agriculture has stripped the soils of essential nutrients. Herbicides and pesticides then poison foods. And the widely used glyphosate herbicide (RoundUp) actually depletes nutrients in foods by blocking their uptake in plants leading to further depletion in crop foods. Food processing then strips out additional nutrients. Get the picture?

On top of all this, your requirements for nutrients are increased by factors such as pollution and chemical exposures (and greater stress on detoxification organs), emotional stress, immune stresses (like fighting off colds or flu), and even free-radical stress caused by electromagnetic fields (EMFs) such as mobile phone and Wi-Fi exposures. In many cases, various stresses and environmental exposures put a greater burden on your antioxidant defense systems by subjecting you to free-radical attack. This is just the beginning.

Assuming your diet were “perfect” (which most likely it is not), your needs for various nutrients will vary depending on your levels of exposure to stresses (emotional, chemical, electromagnetic, etc.). This means that as your needs for extra nutrients rise to combat these stresses, the simplest and best way to meet those needs is through consuming additional, supplemental amounts of nutrients—to successfully meet those needs. Otherwise, having only minimal amounts (i.e., daily values created to avoid deficiency diseases) means your need for higher amounts will not be met.

IF YOU DO NOTHING ELSE, TAKE A HIGH-QUALITY MULTIVITAMIN

A multivitamin can meet those additional needs, or at least start meeting them. In fact, a multivitamin is the best “first line of defense.” In the HPDI system, a multivitamin is just one of six foundational supplements—but it “first among equals” and therefore the very first supplement we recommend. This means that if you do nothing else, then take a multivitamin.

Need another good reason to make a multivitamin? Again, genetics. HPDI has teamed up with Bodysync, the developer of Nutrisync genetic tests (available to HPDI resellers on the reseller website and to retail customers by phone) that offers testing for health-related genetic variations in your DNA.

Among the first things we realized after analyzing Nutrsync genetic test results is that many genetic variants that may cause problems with uptake of certain nutrients—or that require additional amounts of nutrients—can be partly or wholly mitigated by taking a high-potency multivitamin. This is not true in every case, but surprisingly the nutrients provided in a quality multivitamin can be a strong defense in this regard.

Another thing we noticed is that the results of almost everyone taking the Nutrisync test exhibit certain genetic weaknesses that would benefit from a multivitamin. Another “no brainer” observation that may not have been so obvious beforehand, yet which corresponds with what we have been recommending to clients for decades: Take a multivitamin!

People may not realize that optimal health is within reach. Taking a high-potency multivitamin daily is a major first step toward achieving it.

BENEFITS OF A HIGH-QUALITY, HIGH-POTENCY MULTIVITAMIN

Considering all the factors involved in optimal nutrition—and how important nutrition is to health—it is remarkable to think that your health can be well maintained or dramatically improved simply by taking a high-potency multivitamin. Yet, that is a fact. And

• Ensures complete nutrition by providing a wide-range of nutrients to supplement those obtainable by diet
• Provides optimal levels of nutrients in a balanced way
• Guards against deficiencies of particular nutrients
• Protects against nutrient depletion caused by increased needs for nutrients (e.g., various stresses or periods of inadequate intake).
• Helps you fulfill genetic potential by supplying nutrients required for optimal genetic expression and for overcoming adverse genetic factors
• Safe, low cost, and effective means to support good health

BENEFITS OF HPDI MULTIVITAMINS

HPDI formulates and sells some of the highest-quality, high-potency multivitamins available. Many of our customers are health professionals who supply their clients with our multivitamins—because health professionals demand supplements proven to be effective. And they know the difference!

• HPDI multivitamins provide a complete range of nutrients, including vitamins, minerals, cofactors, and phytonutrients
• Therapeutic levels of nutrients in amounts necessary for health—typically greater than daily values
• Nutrients balanced so as not to provide too little or too much of any given nutrient
• High-purity with minimal excipients, and avoidance of harmful excipients
• Advanced forms (including coenzyme vitamins) for optimal uptake, transport, and utilization
• Inclusion of coenzyme form B vitamins
• Inclusion of potent antioxidants and Nrf2 activators
• Formulated by Hank Liers, PhD, designer of supplements for 30 years
• Vegetarian capsules

HPDI MULTIVITAMINS

Health Products Distributors, Inc. (HPDI) currently offers five multivitamins, including Mighty Multi-Vite!, Multi Two (tabs and caps), Mini Multi, and Chewable Kids Mighty-Multi. Each multivitamin is formulated for a specific purpose:

Multi Two and Mighty Multi-Vite! are flagship multivitamins with advanced forms. Multi Two offers higher levels of B vitamins, whereas Mighty Multi-Vite! provides relatively more antioxidants and phytonutrients.

Mini Multi is formulated for chemically and environmentally sensitive individuals or those who seek ultra-high purity. Mini Multi contains no excipients (i.e., additives or fillers), and provides 100% coenzyme vitamins.

Chewable Kids Mighty-Multi! tastes great and includes xylitol to prevent cavities. Kids love this chewable formula, but it is also scalable for adults. This formula is most similar to Mighty Multi-Vite! in terms its nutrient content.

HPDI multivitamins

HPDI multivitamins: Multi Two (caps and tabs), Mighty Multi-Vite!, Mini Multi, and Chewable Kids Mighty-Multi.

HPDI MULTIVITAMINS IN DEPTH

1. MIGHTY MULTI-VITE!

HANK & BRIAN’S™ MIGHTY MULTI-VITE! (or as we often call it, the “Mighty Multi”) is perhaps the premier HPDI multivitamin, and definitely among the flagship multivitamins we offer. I personally take this one most of the time. It is in the “Hank & Brian’s” line, which generally are among our best products.

Mighty Multi incorporates the latest nutritional research in a complete formula that combines the highest-quality, most assimilable forms of vitamins and minerals along with advanced herbal nutrition.

Mighty Multi-Vite! is an advanced, cutting-edge multivitamin that is a leader within HPDI’s line of foundational supplements. This formula exhibits superior performance with respect to supporting optimal health, and is among the world’s most sophisticated multivitamins. Mighty Multi-Vite! works synergistically with other foundational supplements to help sustain maximum health, vitality, and promote longevity.

Now with these 7 absolutely essential improvements:

  • Now in an ultra-pure vegetarian capsule
  • Vitamin B12 is now in the methylcobalamin coenzyme form
  • Turmeric is now in an extract form with 95% curcuminoids – a powerful Nrf2 activator
  • Now uses broccoli sprouts powder containing sulforaphane – another powerful Nrf2 activator
  • Contains both Vitamin K1 and Vitamin K2 (as MK-7)
  • Contains the best coenzyme form of folate – L-5-MTHF
  • Contains no magnesium stearate
Mighty Multi multivitamins

Mighty Multi-Vite! is an HPDI flagship multivitamin offering special nutrients for antioxidant protection.

MIGHTY MULTI-VITE! BENEFITS

COMPLETE, BALANCED ESSENTIAL NUTRITION – Provides a full spectrum of nutrients exceptionally well balanced for creating and maintaining optimal health. Mighty Multi-Vite! offers all the most important vitamins along with minerals, cofactors, antioxidants, and herbs.

RAPID, EASY ASSIMILATION – Incorporates the most bioavailable vitamin and mineral carriers most easily recognized and rapidly assimilated by your body. In addition, the formula uses multiple forms of mineral carriers to ensure assimilation. In addition, the capsule form speeds uptake because it does not require time for the body to break it down (unlike tablets).

ENERGIZING – Includes coenzyme form vitamins and Krebs Cycle bionutrients that work with your body to create super high energy levels. Provides significant levels of B vitamins (especially coenzyme B vitamins) known for boosting energy, supporting the body during times of stress, nerve function, heart function, and for working together with dietary RNA (found in Rejuvenate!™ superfoods) to produce significant therapeutic effects.

FOUNDATIONAL SUPPLEMENT – For creating health and establishing a complete supplement program. Providing excellent foundational nutrition, Mighty Multi-Vite! is designed to work synergistically with other foundational formulas for maximum health benefits.

In addition to the newest improvements, Mighty Multi-Vite! features:

  • A full spectrum of B-complex vitamins, most in coenzyme forms, as well as more conventional forms. Includes Vitamin B1 as thiamin HCl and thiamin diphosphate, Vitamin B2 as riboflavin and riboflavin-5′-phosphate, Vitamin B3 as niacinamide and niacin, Vitamin B5 as pantothenic acid, Vitamin B6 as pyridoxine HCl and pyridoxal-5′-phosphate, folate as L-5-methyltetrahydrofolate (L-5-MTHF), Vitamin B12 as methylcobalamin, and biotin.
  • All of the most absorbable and usable forms of the fat-soluble vitamin group, including Vitamin A (as beta-carotene), Vitamin E (as d-alpha tocopherol succinate), Vitamin D-3 (as cholecalciferol), Vitamin K (as phytonadione and MK-7).
  • A complete and balanced supply of the most abundant carotenoids found in the body, including beta- and alpha-carotene, as well as lycopene and lutein.
  • A variety of the best-known herbal preparations, including quercetin, grape extract, turmeric (95% curcuminoids), broccoli sprouts powder, octacosanol from policosanol, and stevia.
  • All of the known essential minerals in forms readily absorbed and recognized by the body including calcium, magnesium, potassium, zinc, manganese, boron, copper, chromium, molybdenum, vanadium, and selenium.
  • Mineral carriers such as ascorbates, Krebs cycle bionutrients and amino acids providing the body with important metabolic substrates and vitamins, including citrate, succinate, alpha-ketoglutarate, fumarate, malate, glycinate, aspartate, sebacate, and Vitamin C.
  • Includes the important sulfur-containing amino acid N-Acetyl-L-Cysteine to support the body’s antioxidant and detoxification systems and betaine HCl to support digestive processes.
  • Includes choline and inositol which play a crucial role in all of the cell membranes of the body, in brain function, and in liver function.
  • Exclusion of the prooxidant minerals of iron and iodine which can lead to excessive free-radical production and PABA that sometimes adversely affects brain function in some individuals. Note: we sell iodine as separate formulas.
  • Capsule form that ensures the maximum absorption of ingredients.
  • Four-per-day full dosage that allows for partial dosing for children, seniors, and pets.
  • Vegetarian formula – including capsule.
  • Capsule contents designed to smell and taste good to adults and children when emptied into smoothies, drinks, and foods. This allows greater flexibility of use.
  • Exclusion of ingredients such as wheat, gluten, dairy, corn, soy, and egg having well-known antigenic properties and that may be associated with allergy or delayed hypersensitivity reactions.
  • A minimum of excipients, fillers, lubricants, etc. having deleterious effects in some individuals. No GMOs.

As I mentioned previously, the Mighty Multi is uniquely advanced it that it provides special antioxidant ingredients like turmeric, grape extract, and broccoli sprouts powder.

2 & 3. MULTI TWO (CAPS & TABS)

MULTI TWO is another HPDI flagship multivitamin. We recommend it especially for individuals who prefer more B vitamins built into their multivitamin. Yet, it offers somewhat fewer antioxidant nutrients.

MULTI TWO is a pure, complete, biochemically formulated multivitamin supplement with minerals and cofactors. It dissolves readily and is highly bioavailable. All ingredients are sourced for purity and carefully selected to avoid common food allergens. MULTI TWO is available in tablet and vegetarian capsule forms.

MULTI TWO is among HPDI’s most popular multivitamins, providing top-notch quality, high-purity, advanced design and formulation, and exceptional value for the price.

The formula comes in tablet or capsule forms. The tablet is suitable for vegetarians, only containing plant fiber to bind components, further eliminating chemical contaminants. The capsule form now is also vegetarian. The capsules have a four-per-day full dosage allowing for partial dosing for children, seniors, and pets. Note: the capsule’s powder contents taste quite good to most people, so it can be added to sippy cups, blender drinks, smoothies, pet foods, etc.

MULTI TWO is one of HPDI’s foundational multivitamin supplements in our health recovery and maintenance programs. A foundational program of supplements includes a multivitamin, essential fatty acids, a Vitamin C formula, and a Rejuvenate!™ superfood.

multivitamins

Multi Two Caps are among HPDI’s premier therapeutic-grade multivitamin formulas providing a complete range of nutrients.

MULTI TWO OFFERS UNIQUE BENEFITS

  • COMPLETE, BALANCED FOUNDATIONAL NUTRITION. Full-Spectrum of Nutrients Exceptionally Balanced for Supporting Your Health. Foundational Formula Ideal for Providing Essential Foundational Nutrition. A high-quality multivitamin is the foundation (i.e., core) for a complete nutritional supplement program.
  • RAPID AND EFFECTIVE ASSIMILATION. Incorporates Bioavailable Vitamin and Mineral Carriers Your Body Recognizes and Can Assimilate Immediately. Plus, Multiple Carriers Ensure Assimilation. Tablet or Capsule Forms Rapidly Assimilated.
  • POWERFULLY ENERGIZING. Includes Coenzyme Form Vitamins and Krebs Cycle Bionutrients that work with your body to create high energy levels. Full-Spectrum Essential Nutrients Needed For Building, Supporting, and Maintaining Excellent Health.
  • HIGH PURITY. One of the Purest Available Supplements. Carefully Designed To Exclude Common Allergens, and Exclude or Minimize Excipients, Additives, and Fillers.
  • TABLET AND VEGETARIAN CAPSULE FORMS. We Offer Both Forms Giving You More Choice. Take Your Pick.
  • FOUNDATIONAL SUPPLEMENT. Providing solid foundational nutrition, MULTI TWO functions most effectively when used in conjunction with other foundational formulas, especially Vitamin C formulas (including ULTIMATE PROTECTOR™ and PRO-C™), Essential Fatty Acid formulas (including Omega Plus and Essential Fats Plus E), and REJUVENATE!™ superfoods. These foundational supplements together form the foundation of a complete nutritional supplement program. From here, you can add additional supplements (enhancements and specific condition formulas) addressing your individual needs, i.e., by pinpointing where your body requires additional nutritional support.

MULTI TWO FEATURES

  • A full-spectrum of B-complex vitamins, most in coenzyme forms, as well as more conventional forms. Includes Vitamin B1 as thiamin HCl and thiamin diphosphate, Vitamin B2 as riboflavin and riboflavin 5’-phosphate, Vitamin B3 as niacinamide and niacin, and Vitamin B6 as pyridoxine HCl and pyridoxal 5’-phosphate, folate from calcium folinate and 5-MTHF, Vitamin B12 as methylcobalamin and hydroxocobalamin, and biotin.
  • All of the most absorbable and usable forms of the fat-soluble vitamin group, including Vitamin A (as natural beta-carotene), Vitamin E (as d-alpha tocopherol succinate and mixed tocopherols), Vitamin D3 (as cholecalciferol), and two forms of Vitamin K (K1 as phylloquinone and K2 as menaquinone-7).
  • Effective herbal preparations, including quercetin, grape extract, octacosanol.
  • All of the known essential minerals in forms readily absorbed and recognized by the body including calcium, magnesium, potassium, zinc, manganese, boron, copper, chromium, molybdenum, vanadium, and selenium.
  • Mineral carriers such as ascorbates, Krebs cycle bionutrients, and amino acids providing the body with important metabolic substrates and vitamins, including citrate, succinate, alpha-ketoglutarate, fumarate, malate, glycinate, aspartate, sebacate, and Vitamin C.
  • Includes betaine HCl to support digestive processes.
  • Choline and inositol which play a crucial role in all of the cell membranes of the body, in brain function, and in liver function.
  • Exclusion of the prooxidant minerals of iron and iodine which can lead to excessive free-radical production and PABA that sometimes adversely affects brain function in some individuals.
  • Four-per-day full dosage of capsule form allows for partial dosing for children, seniors, and pets.
  • Tablet and capsule forms are vegetarian (except for pharmaceutical glaze on tablets).
  • Exclusion of ingredients such as wheat, dairy, corn, soy, and egg having well-known antigenic properties and that may be associated with allergy or delayed hypersensitivity reactions. Contains no GMOs.
  • A minimum of excipients, fillers, lubricants, etc. that exert deleterious effects in some individuals.

Multi Two is a great multivitamin and in many ways similar to the Mighty Multi-Vite!. However, Multi Two provides more B vitamins and in the case of certain B vitamins, it provides twice as much as Mighty Multi-Vite!. For anyone who requires plenty of B vitamins and who doesn’t necessarily want to take a separate, standalone B vitamin formula, Multi Two is an ideal multivitamin.

For more information, see the full Multi Two product page (capsules) or the Multi Two product page for tablets.

 

4. MINI MULTI

We call our Mini Multi the “World’s Purest Multivitamin.” This is because it was originally formulated for chemically and/or environmentally sensitive persons. The capsule is smaller than our other multivitamins which easily allows for partial dosing. It also is our only all coenzyme form multivitamin.

MINI MULTI is an ultrapure, biochemically formulated, complete multivitamin supplement that includes essential and trace minerals, and cofactors. MINI MULTI is highly bioavailable and contained in a preservative-free veggie capsule (helping eliminate chemical contaminants). The capsule contains no fillers, flow agents, or any other excipients. Each component is the highest purity.

MINI MULTI is ideal for chemically and environmentally sensitive individuals who require ultra-high purity supplements. The formula is designed by Dr. Hank Liers, who developed it as a ultra-pure formula for sensitive individuals. Yet, anyone can take MINI MULTI to benefit from its ultra-high purity and avoidance of additives, fillers, or other excipients.

Many individuals who take MINI MULTI are not chemically sensitive, but suffer from allergies, sensitive digestive tracts, wish to avoid gelatin capsules, or simply do not enjoy swallowing large capsules (or tablets).

multivitamins

Meet Mini Multi, the world’s purest multivitamin formulated originally for chemically and environmentally sensitive persons.

ADVANCED DESIGN INCLUDES NEARLY 100% COENZYME FORM B VITAMINS

MINI MULTI’s biochemical formulation incorporates the latest research on nutrient transport and interaction to enhance efficient metabolism and includes coenzyme forms of vitamins. The vitamins and minerals in MINI MULTI activate the body’s metabolic machinery, and synergistic cofactors aid absorption, assimilation, utilization, and metabolism of nutrients.

MINI MULTI is among the first multivitamins to provide almost all coenzyme form B vitamins (i.e., all except vitamin B3, which we include as niacinamide). Coenzyme form vitamins are the natural forms best recognized and utilized in the body. For example, MINI MULTI provides folate in the form of folinic acid (a natural form of folate) from calcium folinate and L-5-MTHF (another natural form of folate), rather than the typical and commonly used folic acid, a synthetic form requiring enzymatic processing in the body for utilization. That is, coenzyme vitamins are easier to assimilate (especially for older individuals or those with health conditions that reduce enzyme activity in vivo) and they are immediately recognized and used in the body.

FEATURES AND BENEFITS OF THE HIGHEST PURITY FORMULA AVAILABLE TODAY

  1. The world’s purest multivitamin supplement, proven for more than a decade
  2. Ideal for chemically, environmentally or allergen sensitive individuals, or anyone desiring an ultra-high purity in a nutritional supplement
  3. Highly effective, complete formula includes vitamins, minerals, and cofactors (including powerful antioxidants)
  4. Includes nearly 100% coenzyme form B vitamins for rapid assimilation (all except B3 which is included as niacinamide and B5 which is included as pantothenic acid)
  5. Convenient four-per-day dosage allows easy for partial dosing
  6. Suitable for vegans and vegetarians (veggie capsule)
  7. Suitable for children (i.e., capsule may be opened and emptied into drinks or food)
  8. No additives, fillers, flow agents, or any other excipients!
  9. Nothing artificial or synthetic!
  10. Gluten-free
  11. In fact, MINI MULTI does not contain wheat, rye, oats, corn, barley, gluten, egg, dairy, citrus, yeast, sugar, GMOs, wax, sulfates, phosphates (other than coenzymes), preservatives, fillers, binders, coatings, colorings, or artificial flavorings

MINI MULTI exhibits superior design, technical sophistication, ease of use, and high perfomance. We suggest you try it whether you are sensitive to fillers or flow agents, suffer from allergies due to common additives, wish to avoid artificial ingredients, or simply want the purest multivitamin available.

In this day and age when many individuals suffer from allergies to ingredient sensitivities, Mini Multi represents a choice for the ultimate in high-purity. No excipients means a cleaner supplement option for anyone who may need it.

5. CHEWABLE KIDS MIGHTY-MULTI

HPDI’s KIDS MIGHTY-MULTI! is truly one-of-a-kind. It is most similar to the Mighty Multi-Vite! in terms of the nutrients it provides, including antioxidants. However, it is our only chewable and it tastes great.

KIDS MIGHTY-MULTI! is an advanced chewable multivitamin for children incorporating the latest nutritional research in a tasty, complete formula combining the highest-quality and most usable forms of vitamins, minerals, herbs, and cofactors.

Our children’s multivitamin formula provides optimal levels of basic essential nutrients and thereby is an ideal foundation upon which to build a complete nutritional supplement program. A high-quality multivitamin is the starting-point for building a program uniquely designed to suit to your child’s individual requirements.

We offer KIDS MIGHTY-MULTI! as a “top-of-the-line” children’s formula that tastes great and produces exceptional results. This unique formula very effectively provides children with a solid foundation of nutrients for establishing, building, supporting, and maintaining excellent health during this critical period of their lives.

COMPLETE FORMULA – the most complete children’s formulas available! It provides a full-spectrum of essential nutrients needed for creating, supporting, and maintaining excellent health for your child. It includes natural coenzyme form vitamins and Krebs cycle bionutrients that work with young bodies to provide energy for metabolic processes, healing, and optimal heatlh.

AMAZING TASTE, NATURALLY the most delicious kids multivitamin you’ll ever taste! Flavored with only healthy, natural sweeteners and functional taste enhancers, including mannitol, xylitol, fructooligosaccharides (FOS) (from chicory root), natural fruit flavor, and stevia leaf extract. Most of these taste enhancers actually exhibit other positive benefits in the body (i.e., prebiotic effects, cavity prevention, and antioxidant action). Kids (and adults) love the taste!

BALANCED ESSENTIAL NUTRIENTS – exceptionally balanced nutrients for supporting your child’s health. This is a foundational formula ideal for providing basic nutrients for health. Indeed, a high-quality multivitamin is a basic foundational formula (along with vitamin C and essential fatty acid formulas) in a nutritional supplement program. Our kids’ formula puts your child on the nutritional track he or she deserves right from the start!

“ULTRA PURE”
– excludes common food source allergens (like wheat, corn, soy, or dairy). Also excludes unnecessary excipients, fillers, binders, and additives. Unlike many children’s vitamins, ours contains NO artificial colorings or flavorings, artificial sweeteners (like aspartame, saccharin, or sucralose) or hydrogenated vegetable oils…substances that can have deleterious effects on health (yet are frequently include. Plus, NO sugar and NO GMOs!

RAPID ASSIMILATION
– incorporates bioavailable vitamin and mineral carriers the body recognizes and can assimilate immediately. Plus, multiple carriers ensure assimilation. Chewable form speeds uptake in the body.

FOUNDATIONAL FORMULA – forms the foundation of a complete supplement program for your child. Formulated to work with other foundational formulas, including Vitamin C formulas (like PRO-C™) and essential fatty acid formulas (like Essential Fats plus E) that together form the basis of a complete nutritional supplement program. You can also add specific supplements addressing your individual needs of your child, i.e., by pinpointing where he or she may require additional nutritional support. Such specific supplements might include Allergy Support Plus, Joint Health Formula, or Ultimate Protector™ (super antioxidant & Nrf2 activator formula).

Kids Mighty-Multi is the perfect multivitamin for kids offering appropriate levels of a wide range of important vitamins, minerals, cofactors, and antioxidants.

KIDS MIGHTY-MULTI! FEATURES

• A full-spectrum of B-complex vitamins primarily in coenzyme forms, including Vitamin B1 (as thiamin diphosphate), Vitamin B2 (as riboflavin-5’-phosphate), Vitamin B3 (as niacinamide and niacin), Pantothenic acid), Vitamin B6 (as pyridoxal 5’-phosphate), folate (as 5-MTHF), Vitamin B12 (as methylcobalamin), and Biotin.

• All of the most absorbable and usable forms of the fat-soluble vitamin group, including Vitamin A (as natural beta-carotene), Vitamin E (as d-alpha tocopherol succinate and mixed tocopherols), Vitamin D3 (as cholecalciferol), and Vitamin K (as phylloquinone (K1) and MK-7 (K2)).

• A complete and balanced supply of the most abundant carotenoids found in the body, including Beta-Carotene, Lycopene, and Lutein.

• A variety of the best-known herbal ingredients, including Quercetin, Grape Extract, Turmeric extract, Broccoli Sprouts Powder, and Octacosanol (from policosanol).

• Readily absorbed forms of all essential minerals, including Calcium, Magnesium, Potassium, Zinc, Iron, Manganese, Boron, Copper, Chromium, Molybdenum, Vanadium, and Selenium.

• Easily assimilated mineral carriers, including ascorbates (Vitamin C), Krebs cycle bionutrients (citrate, succinate, alpha-ketoglutarate, fumarate, malate), and amino acids (e.g., glycine, taurine, and aspartic acid) that provide the body with important metabolic substrates and vitamins.

• Sulfur-containing amino acids supporting the body’s detoxification systems.

• Natural taste-enhancing complex of xylitol, mannitol, FOS, and stevia leaf extract. Tasty fruit flavor kids love!

• Therapeutic levels of xylitol helping to prevent cavities.

• Significant levels of choline and inositol that play a crucial role in all cell membranes, and in brain and liver function.

• Betaine HCl to support digestive processes.

• Exclusion of the pro-oxidant mineral iodine that may lead to excessive free radical production and PABA that can adversely affect brain function. We actually prefer the safer and more therapeutic Nascent Iodine over the forms normally found in vitamin formulas.

• Exclusion of substances that have well-known antigenic properties and that may be associated with allergy or delayed hypersensitivity reactions, including wheat, corn, soy, egg, and dairy.

• Minimum of excipients, fillers, or additives (that may have deleterious effects in some individuals).

• Small tablet size allows for weight-dependent dosing (two tablets per 20 lbs body weight)

MORE ABOUT KIDS MIGHTY-MULTI!

A Better, Safer Multivitamin for Kids

The vast majority of children’s vitamins today are decidedly not advanced formulations. They typically provide only minimum amounts (i.e., no more than government mandated daily values) of vitamins, minerals, and other nutrients. In addition, most kids’ vitamin on the market remain filled with sugars and artificial ingredients, including aspartame (a known toxin), artificial colorings, preservatives, hydrogenated oils, and other toxic substances.

Consider what our Kids Mighty-Multi! does NOT contain:

  • Aspartame. There is controversy surrounding this artificial sweetener, which is associated with a variety of neurological problems. In fact, there is widespread consensus that children under six should not use aspartame. We believe no one should consume aspartame at any age!
  • Refined sugars (usually listed as, sucrose, etc.). There is no place for sugar in multivitamins. Sugar in supplements is also dangerous because when coupled with ascorbic acid, it can damage teeth! Chewable kids vitamins containing sugar expose your child’s teeth to double jeopardy.
  • Artificial dyes (FD&C Yellow, Blue, and/or Red). Artificial colors are associated with a wide range of health and behavioral problems. These include carcinogenicity, and contributing to learning problems like ADHD. In addition, FD&C Yellow dye #5 (tartrazine) is one of the main food triggers of asthma attacks.
  • Benzoates, sulfur dioxide, sulfites. These are bad because they are all preservatives that have no business being in a health supplement. They all are known to stimulate allergic reactions.
  • Hydrogenated oils. These are the bad, sticky fats that are found in junk foods and are harmful to your child’s heart. Incredibly, some companies put hydrogenated oils in a children’s vitamin!

As you can see, our children’s chewable multivitamin is not your ordinary kids multivitamin, and it provides all the benefits of our other multivitamins in a tasty chewable format. In fact, many adults take it who prefer a chewable over a capsule or tablet. It is uniquely formulated to be scalable for adults at the dosage of two tablets per 20 lbs body weight.

multivitamins

Chewable Kids Mighty-Multi tastes great, provides advanced forms of nutrients, and scales up for adults.

CONCLUSION: TAKE A MULTIVITAMIN

Multivitamins are the first supplement most people need and should take. Taking a high-potency, high-purity multivitamin daily provides many benefits beyond what you might expect. This includes everything from ensuring against deficiencies to providing amounts necessary for optimal health, and for compensating for greater needs depending on your unique biochemical individuality. Given the overarching safety and relatively low cost of multivitamins, they are best “first defense” in a nutrient-depleted world.

HPDI offers four of the best multivitamins available anywhere, and five if you consider that Multi Two is available in capsules or tablets. So take your pick among them, and be the healthiest you can be.

MULTIVITAMIN RESOURCES

HPDI Multivitamins

Mighty Multi-Vite!

Multi Two (Capsules)

Multi Two (Tablets)

Mini Multi

Kids Mighty-Multi! (Chewable)

ARTICLES & e-BOOKS

“Why You Need Foundational Supplements”

The Need for Foundational Supplements e-book (.pdf)

“Rejuvenation Program Part Four”

“Choosing Supplements for a Complete Nutritional Supplements Program”

Discovering Nutritional Needs Through Advanced Genetic Testing

No Deaths from Vitamins. None. Safety Once Again Confirmed by America’s Largest Database” (Orthomolecular News Service, 2017)

VIDEOS

HPDI Foundational Supplements – VIDEO

Health Products Distributors, Inc.

THE TRUTH ABOUT ESSENTIAL FATTY ACIDS

The Truth About Essential Fatty Acids

Dr. Hank Liers, PhD essential fatty acidsMany in the field of nutrition have lost sight of the fact that there are two essential fatty acids needed by the body. Many people recommend omega-3 fatty acids assuming the the body gets sufficient omega-6 from the diet. The truth about essential fatty acids is more complicated. This article will show the more complete and correct picture.

BACKGROUND

Fatty acids are part of the lipids class, widely found in nature, food, and organisms. These fatty acids are a critical constituent of the cell membranes in all of the trillions of cells in the body. They have important biological functions including structural, communication, and metabolic roles, and they represent an important source of energy. Their metabolism produces a huge quantity of adenosine triphosphate (ATP). The beta-oxidation of the fatty acids is a well-known process, mostly used by the heart and the muscular tissue to obtain energy.

Figure 1 below shows a schematic diagram of what a fatty acid looks like. One end of the structure in all cases has a carboxylic acid group (COOH) and the other end in all cases has a methyl group (CH3). Saturated fats have single bonds (-) between all carbon atoms (C), but unsaturated fats have a number of double bonds (=) between some of the carbon atoms.


essential fatty acids

Figure 1 – Basic diagram of fatty acids structure

The human body can synthesize many of these fatty acids, except the essential fatty acids (PUFAs) linoleic acid (LA) and alpha-linolenic acid (ALA). These two are generally found in various vegetable oils, but their important metabolites are found mainly in special vegetable oils such as borage oil and in fish oils. Linoleic acid is the most abundant fatty acid in nature, and it is the precursor of other omega-6 fatty acids. Omega-3 fatty acids are synthesized from alpha-linolenic acid.

Once ingested, short-chain PUFAs are converted to long-chain fatty acids. These are critical for mammalian cells in order to perform various biological functions, such as sustaining the structural integrity of cellular membranes and serving as signaling molecules. They are highly enriched in brain tissues, where they participate in the development and maintenance of the central nervous system during both embryonic and adult stages.

Polyunsaturated fatty acids have been extensively researched. They include the essential fatty acids linoleic acid (an omega-6) and alpha linolenic acid (an omega-3). Omega-3s are not abundant in our food chain. There is none in corn oil and very little in soy oil, the two most widely used food oils. Therefore, nearly all the early research with polyunsaturated oils utilized omega-6 fatty acids, predominantly as linoleic acid.

Fish oils were neglected out of ignorance or because the investigators chose to pass over these cholesterol-containing oils. Concern eventually developed over the close association between increasing incidence of mammary tumors and high intake of omega-6 polyunsaturated fatty acids. After some years, researchers finally turned their investigations to the interrelationship between dietary omega-6 and omega-3 fatty acids.

FATTY ACID METABOLIC PATHWAYS

The following diagram shows in detail the pathways for the production and use of fatty acids in the body. In the figure the metabolic pathways (running left to right) for four fatty acids types are shown (top – Omega-3, second – Omega-6, third – Omega-9, bottom – Omega-7). Notice that only the omega-3 and omega-6 oils are considered to be essential fatty acids because they cannot be made in the body. This means they must come from food.

essential fatty acids

Figure 2 – fatty acid metabolism pathways in the body

The diagram shows a series of enzyme induced reactions that either add a double bond or two additional carbon/hydrogen pairs to the fatty acid. The enzymes that make this happen are called desaturase and elongase. The desaturase enzymes are given a number for the carbon number (that the enzyme is working on) from the methyl end of the fat. These same enzymes work on all of the fatty acid types. For example, Delta 6 desaturase causes an additional double bond to be inserted into both alpha-linolenic (omega-3) and linoleic acid (omega-6) (as well as oleic acid and palmitoleic acids).

In this way, the body is able to produce a wide variety of fatty acids that have their own unique effects on biochemistry. Some of these are more important than others. In particular, the omega-3 essential fatty acid eicosapentanoic acid (EPA), the omega-6 essential fatty acid dihomo-gamma-linolenic acid (DGLA), and the omega-6 essential fatty acid arachidonic acid (AA) are precursors for a class of chemicals called eicosanoids/prostaglandins that have far reaching affects on key body functions.

EICOSANOIDS/PROSTAGLANDINS

Eicosanoids are prostaglandins that affect many aspects of health both positively and, in some cases, negatively. All known eicosanoids and prostaglandins are formed from the essential fatty acids linoleic acid (omega-6, or n-6), alpha linolenic acid (omega-3, or n-3), their “enhanced” derivatives, and from the omega-3 fatty acids in fish oils.

Prostaglandins are short-lived highly active, hormone-like chemicals that are found in every cell of the body. They are regulators of cell activity and essential for maintaining health. Each cell type or organ produces its own form of prostaglandin to carry out its functions. There are three types of prostaglandins: PG1, PG2, and PG3.

Series 1 Prostaglandins (PG1), derived from gamma-linolenic acid (GLA), the active component of borage oil, has many beneficial effects: It makes platelets less sticky, lowers blood pressure by relaxing smooth muscles in the walls of arteries, increases loss of sodium and water, decreases inflammation and enhances immunity.

Series 2 Prostaglandins (PG2), also derived from GLA, is used in “fight or flight” (stress) situations, – the fight against danger, or the flight from it. In modern lifestyles which are high in stress but low in physical activity, continuous production of Series Two Prostaglandins results in sticky platelets, high blood pressure, increased water and sodium retention, increased inflammation and decreased immune system capabilities.

Series 3 Prostaglandins (PG3), derived from eicosapentaenoic acid (EPA), the active component of fish oil, has beneficial effects. They block the detrimental effect of the Series 2 Prostaglandins, preventing them from being made in the body. As a result the platelets are less sticky, blood pressure is lower because the muscles in the walls of our arteries remain relaxed, loss of sodium and water by the kidneys takes place more effectively, inflammation response is decreased, and immune function is efficient.

It is now known that the ratios of these dietary fatty acids are very important. Consumption of linoleic acid leads to production of the enhanced fatty acid, arachidonic acid (20:4n-6). Prostaglandins based on arachidonic acid exacerbate stress and inflammatory states, and suppress immunoprotective functions (i.e. resistance to disease). Too much linolenic acid and other omega-3s may cause excessive bleeding during injury, surgery, or childbirth. Large amounts of any of these unsaturated fatty acids in the diet without a compensatory increase in antioxidant nutrients (especially Vitamin E), can speed oxidative damage to tissues, resulting in accelerated aging while increasing the risk of degenerative diseases.

Yet, a balanced ratio of both omega-3 and omega-6 fatty acids in the diet offers very positive health benefits. When omega-3 fatty acids predominate, the body will produce less arachidonic acid (20:4n-6). Immunity improves and inflammation subsides.

Essential Fats

Unfortunately, our Western diet has been almost devoid of omega-3 fatty acids. Creating the optimum intake of omega 3-to-omega 6 unsaturated fatty acids has become, therefore, an issue of prime importance for anyone concerned with health. We need to evaluate carefully the amounts of linoleic acid (n-6) we consume relative to our intake of alpha-linolenic acid (18:3n-3) and fish oils (EPA:20:5n-3 and DHA:22:6n-3).

ESSENTIAL FATTY ACIDS – PATHWAYS

The diagram in Figure 3 shows details of the omega-6 and omega-3 pathways. Pathway specifics indicate key eicosanoids (series 1 prostaglandins, series 2 prostaglandins, and series 3 prostaglandins), oil sources, and important nutrient cofactors that are needed for the reactions to take place.

essential fatty acids

Figure 3 – Essential Fatty Acids – pathways in the body

The information is this diagram gives the clues we need in order to provide optimal types and amounts of omega-6 and omega-3. For example, I have chosen for my essential fatty acid product cold pressed borage oil as the best natural source of gamma linoleic acid (GLA). It contains 20% by weight — the highest amount found in natural oils.

RESEARCH ON ESSENTIAL FATTY ACIDS

Work by Chapkin et. al. (see references 1–4 below) has identified the potent synergistic relationship between GLA, an omega-6 fatty acid, and the well-known omega-3 fatty acids. Chapkin has shown that, rather than simply the quantity of dietary omega-3s, it is the ratio of omega-6 to omega-3 fatty acids that is important in achieving full cardiovascular health and inflammatory control.

Furthermore, Chapkin has identified the ideal ratio. His published work deals with the importance of mixed diets supplying both linoleic and linolenic acids. To underscore the importance of these two fatty acids, refined oil supplements rich in enhanced forms were used. “Enhanced forms” are fatty acids derived from the original. They are one or more steps closer to the actual eicosanoid. In the human body, alpha linolenic acid (18:3n-3) is eventually converted to eicosapentaenoic acid (EPA, 20:5n-3) and linoleic acid (18:2n-6) is converted to gamma-linolenic (GLA, 18:3n-6) as its first enhanced form. Both enhanced fatty acids are precursors to eicosanoids.

In Chapkin’s research, superior health benefits were delivered by the mixed diet that supplied the eicosanoid precursors in a specific ratio. The balanced ratio of enhanced Omega-6 (GLA)-to-Omega-3 (EPA) fatty acids was 1:4.

IMPLEMENTATION OF THE SCIENCE

Based upon the science discussed above, I developed a product with the correct Omega-6 (GLA)-to-Omega-3 (EPA) ratio and with proper amounts. It is available to you as Hank & Brians Essential Fats Plus E from Health Products Distributors, Inc. (HPDI).

Essential Fats Plus E

ESSENTIAL FATS PLUS E IS A HIGHLY ADVANCED ESSENTIAL FATTY ACIDS SUPPLEMENT
OFFERING SPECIAL BENEFITS:

  1. UNIQUE COMBINATION — Essential Fats (EPA, DHA, GLA) plus Vitamin E. This unique formula offers more than one type of Vitamin E (not just d-alpha-tocopherol) and balanced essential fats.
  2. BALANCED ESSENTIAL FATS— Many EFA supplements contain only omega-3s, but for optimal function the body requires a balance of omega-3 and omega-6 essential fats. In addition, our special formula provides a 4-to-1 ratio of EPA to GLA in order to achieve a balance you need for optimal health.
  3. FULL-SPECTRUM VITAMIN E — Tocotrienols and tocopherols in this formula are natural vitamin E substances derived from oryza rice bran oil and protect polyunsatured EFAs against free-radical damage both in the capsule and in your body. Many Vitamin E supplements contain only d-alpha tocopherol, which is only a single component of the full-spectrum Vitamin E in this formula.
  4. ULTRAPURE — Molecularly distilled oils of extremely high-purity containing no PCBs, heavy metals, or oxidized contaminants. Free of excipients, additives, and common food allergens!

COMPOSITION: Six softgel capsules provides the following percentages of the Daily Value.

NUTRIENT AMOUNT % Daily Value†
EPA (Eicosapentaenoic Acid 20:5 omega 3)
(from 2,000 mg of purified fish oils)
360 mg *
DHA (docosahexaenoic Acid 22:6 omega 3)
(from 2,000 mg of purified fish oils)
240 mg *
GLA (Gamma Linolenic Acid 18:3 omega 6)
(from 450 mg of cold pressed borage seed oil)
90 mg *
Vitamin E (d-alpha-tocopherol) (from 180 mg of Oryza rice bran oil) 24 IU 81%
Mixed Tocotrienols (d-gamma, d-alpha, and d-delta)
(from 180 mg of Oryza rice bran oil)
28.8 mg *

* No established Daily Value
† Daily Values based on a 2,000 calorie diet

IMPORTANT FUNCTIONS OF ESSENTIAL FATTY ACIDS

Below we provide some of the functions and benefits obtained when by diet or supplementation the correct ratios and amounts of essential fatty acids are consumed.

• Regulate steroid production and hormone synthesis
• Regulate pressure in the eyes, joints, and blood vessels
• Regulate response to pain, inflammation, and swelling
• Mediate Immune Response
• Regulate bodily secretions and their viscosity
• Dilate or constrict blood vessels
• Regulate smooth muscle and autonomic reflexes
• Are primary constituents of cellular membranes
• Regulate the rate at which cells divide
• Necessary for the transport of oxygen from the red blood cells to tissues
• Necessary for proper kidney function and fluid balance
• Prevent red blood cells from clumping together
• Regulate nerve transmission

GENETIC TESTING AND ESSENTIAL FATTY ACIDS

Please note that genetic testing for a wide range of genes and the enzymes they produce has indicated that essential fatty acids can be an important factor in helping the body overcome a variety negative gene variations. These negative gene variations include genes that relate to: 1) Inflammatory Response, 2) Exercise Performance, 3) Exercise Recovery, 4) Cardiovascular Fitness, 5) Body Composition, and 6) VO2 Max, Aerobic Capacity.

We will discuss this more deeply in a future blog article.

CONCLUSION

The body is best protected from a range of health issues when we supply a mixed diet of both omega-3 and omega-6 essential fatty acids. Studies show that we do not need to consume large amounts of fatty acids if the ratio is correct. These findings indicate that, for a typical human body, amounts of 90 mg GLA (18:3n-6) to 360 mg EPA (20:5n-3) taken daily will provide for the optimum production of the three major prostaglandins. These amounts are found in Hank & Brians Essential Fats Plus E.

REFERENCES

The following includes abstracts of Chapkin’s published research on essential fatty acids.

REFERENCE 1

Chapkin RS Somers SD Erickson KL

Dietary manipulation of macrophage phospholipid classes: selective increase of dihomogammalinolenic acid.

In: Lipids (1988 Aug) 23(8):766-70

Because alterations in the dietary content of fatty acids are an important method for modulating macrophage eicosanoid production, we have quantitated the levels of n-6 and n-3 polyunsaturated fatty acids in peritoneal macrophage individual phospholipids from mice fed diets (3 wk) with either safflower oil (SAF), predominantly containing 18:2n-6, borage, (BOR) containing 18:2n-6 and 18:3n-6, fish (MFO) containing 20:5n-3 and 22:6n-3, and borage/fish mixture (MIX) containing 18:2n-6, 18:3n-6, 20:5n-3 and 22:6n-3. Dietary n-3 fatty acids were readily incorporated into macrophage phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylserine (PS) and phosphatidylinositol (PI). The increase in n-3 fatty acid levels was accompanied by a decrease in the absolute levels of 18:2n-6, 20:4n-6 and 22:4n-6 in PC, PE and PS. Interestingly, PI 20:4n-6 levels were not significantly lowered (P greater than 0.05) in MIX and MFO macrophages relative to SAF and BOR. These data demonstrate the unique ability of this phospholipid to selectively maintain its 20:4n-6 levels. In BOR and MIX animals, 20:3n-6 levels were significantly increased (P less than 0.05) in all phospholipids relative to SAF and MFO. The combination of borage and fish oils (MIX diet) produced the highest 20:3n-6/20:4n-6 ratio in all phospholipids. These data show that the macrophage eicosanoid precursor levels of 20:3n-6, 20:4n-6 and n-3 acids can be selectively manipulated through the use of specific dietary regimens. This is noteworthy because an increase in phospholipid levels of 20:3n-6 and 20:5n-3, while concomitantly reducing 20:4n-6, may have therapeutic potential in treating inflammatory disorders.

Institutional address: Department of Human Anatomy School of Medicine University of California Davis 95616.

 

REFERENCE 2

Chapkin RS Carmichael SL

Effects of dietary n-3 and n-6 polyunsaturated fatty acids on macrophage phospholipid classes and subclasses.

In: Lipids (1990 Dec) 25(12):827-34

This study examined the effects of n-3 and n-6 polyunsaturated fatty acid alimentation on murine peritoneal macrophage phospholipids. Mice were fed complete diets supplemented with either corn oil predominantly containing 18:2n-6, borage oil containing 18:2n-6 and 18:3n-6, fish/corn oil mixture containing 18:2n-6, 20:5n-3 and 22:6n-3, or fish/borage oil mixture containing 18:2n-6, 18:3n-6, 20:5n-3 and 22:6n-3. After two weeks, the fatty acid levels of glycerophosphoserines (GPS), glycerophosphoinositols (GPI), sphingomyelin (SPH), and of the glycerophosphocholine (GPC) and glycerophosphoethanolamine (GPE) phospholipid subclasses were determined. We found that mouse peritoneal macrophage GPC contain primarily 1-O-alkyl-2-acyl (range for the dietary groups, 24.6-30.5 mol %) and 1,2-diacyl (63.2-67.2 mol %), and that GPE contains 1-O- alk-1′-enyl-2-acyl (40.9-47.4 mol %) and 1,2-diacyl (44.2-51.2 mol %) subclasses. In general, fish oil feeding increased macrophage 20:5n-3, 22:5n-3 and 22:6n-3 levels while simultaneously reducing 20:4n-6 in GPS, GPI, GPE and GPC subclasses except for 1-O-alk-1′-enyl-2-acyl GPC. Administration of 18:3n-6 rich diets (borage and fish/borage mixture) resulted in the accumulation of 20:3n-6 (2-carbon elongation product of 18:3n-6) in most phospholipids. In general, the novel combination of dietary 18:3n-6 and n-3 PUFA produced the highest 20:3n-6/20:4n-6 phospholipid fatty acid ratios. This study demonstrates that marked differences in the responses of macrophage phospholipid classes and subclasses exist following dietary manipulation.

 

REFERENCE 3

Fan YY Chapkin RS

Mouse peritoneal macrophage prostaglandin E1 synthesis is altered by dietary gamma-linolenic acid.

In: J Nutr (1992 Aug) 122(8):1600-6

The ability of dietary gamma-linolenic acid [18:3(n-6)] to modulate prostaglandin biosynthesis in mouse resident peritoneal macrophages was determined. Mice were fed diets containing corn oil, borage oil or evening primrose oil or a mixture of borage and fish oils. After 2 wk, resident peritoneal macrophages were isolated and stimulated with unopsonized zymosan to induce prostaglandin synthesis. Borage oil, primrose oil and fish-borage oil mixture dietary groups (containing 25.6, 11.9 and 19.5 g gamma-linolenic acid/100 g fatty acids, respectively) had significantly (P less than 0.05) enhanced prostaglandin E1 synthesis (39.7, 29.4 and 73.0 nmol prostaglandin E1/mg protein, respectively) compared with corn oil-fed (containing less than 0.1 g gamma-linolenic acid/100 g fatty acids) animals, which synthesized less than 0.1 nmol prostaglandin E1/mg protein. Borage oil- and fish-borage oil mixture-fed mice had the highest biosynthetic ratio of prostaglandin E1/prostaglandin E2 (E1/E2 approximately 0.2). Macrophages from borage oil-fed mice synthesized the lowest amount of prostacyclin (198.7 nmol 6-keto-prostaglandin F1 alpha/mg protein) compared with corn oil-, primrose oil- and fish- borage oil mixture-fed mice (379.7, 764.8 and 384.2 nmol 6-keto- prostaglandin F1 alpha/mg protein, respectively). In addition, borage oil-, primrose oil- and fish-borage oil mixture-fed mice had significantly (P less than 0.05) higher levels of dihomo-gamma- linolenic acid [20:3(n-6)] in membrane phospholipids (5.5, 3.5 and 5.7 mol/100 mol, respectively) relative to corn oil-fed mice (2.0 mol/100 mol).

 

REFERENCE 4

Fan YY Chapkin RS Ramos KS

Dietary lipid source alters murine macrophage/vascular smooth muscle cell interactions in vitro.

In: J Nutr (1996 Sep) 126(9):2083-8

This study was conducted to compare the impact of dietary lipids on the ability of macrophages to modulate vascular smooth muscle cell (SMC) DNA synthesis in vitro. C57BL/6 female mice were fed six different diets (6 mice/diet) containing 10% fat from corn oil (CO), borage oil (BO), primrose oil (PO), fish-corn oil mix (FC, 9:1, w/w), fish-borage oil mix (FB, 1:3, w/w), or fish-primrose oil mix (FP, 1:3, w/w) for 2 wk. Peritoneal macrophages were isolated from these mice, stimulated with zymosan or vehicle, and subsequently co-cultured with naive mouse aortic SMC in the presence of 3H-thymidine to measure SMC DNA synthesis. In this co-culture system, macrophages were seeded on 25-mm culture inserts (upper chamber) and SMC were seeded on 35-mm culture dishes (lower chamber). The two cell types were separated by a semipermeable membrane with a 30-kD cut-off. When quiescent SMC were co-cultured with macrophages, only the PO and FP diet groups had significantly (P < 0.05) lower SMC DNA synthesis compared with the control CO group whose diet contained no gamma- linolenic acid (GLA) or (n-3) polyunsaturated fatty acids (PUFA). In contrast, when cycling SMC were co-cultured with diet-modulated macrophages, all dietary groups except for those fed FC had significantly lower (P < 0.05) SMC DNA synthesis relative to the CO group. Although the level of GLA in PO and BO diets was different (11.5 and 22.3 g/100 g fatty acids, respectively), these treatments exerted comparable inhibitory effects on SMC DNA synthesis. The FP treatment consistently exhibited the lowest SMC DNA synthetic profile among the six dietary groups irrespective of SMC growth conditions. These data suggest that BO and PO alone or in combination with fish oil influence macrophage/smooth muscle cell interactions in a manner consistent with favorable modulation of the atherogenic process.

These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

BOOKS

  1. Enig, Mary G. Know Your Fats: The Complete Primer for Understanding the Nutrition of Fats, Oils, and Cholesterol. Bethesda Press, 2000.