Dr. Hank Liers, PhD mighty multi vite multivitamin supplementFred Liers PhD Hank Brian mighty multi vite multivitamin

Think you take a complete multivitamin? Well, maybe not. Typical multivitamins simply do not provide enough nutrients for optimal health. Or for that matter, the proper forms and carriers of nutrients to do the job right—the all important task of providing you with essential nutrients for health. Not so easy these days? Well, Hank & Brian’s Mighty Multi-Vite! can help—a lot!


The task of providing you with a complete set of nutrients—as easily absorbed forms—is where Hank & Brian’s Mighty Multi-Vite! shines brightly in the world of #multivitamins. Quite simply, Dr. Hank Liers carefully formulated Mighty Multi-Vite! as the most advanced, complete multivitamin available. It uniquely includes a wide range of vitamins, minerals, cofactors, herbs, antioxidants, and Nrf2 activators (nutrients that allow your body to make its own antioxidants). This wide range of nutrients alone puts Mighty Multi-Vite! in a class by itself.

Calling HPDI’s Mighty Multi-Vite! “complete” is an understatement. While other multivitamins may contain more ingredients, Dr. Hank’s goal is not to “stuff” as many ingredients (or amounts) into Mighty Multi-Vite! as possible. That is a “shotgun” approach—Dr. Hank avoids it—that often results in too large capsules, huge tablets (“horse pills”), or eight-per-day dosages that are hard to consume—and even harder to stick with over time. You get the idea.

Instead, Dr. Hank carefully designed Mighty Multi-Vite! to include both a broad range of essential nutrients and abundant amounts of the most important nutrients for health in easily to assimilate forms using multiple carriers that give the body choices. For example, the body requires far smaller amounts of coenzyme B vitamins (which are the  natural forms best utilized by cells) than conventional forms of B vitamins. This allows for more efficient dosing and does not “waste” space in the capsule allowing more room for other nutrients, like antioxidants and Nrf2 activators. In a nutshell, few multivitamins are so well balanced and designed carefully to give the body what it needs for optimal health. You get it all in just four (4) regular size capsules, daily. How easy is that?

As I mentioned, Mighty Multi-Vite! includes highly absorbable forms of nutrients. These include mineral carriers like Krebs Cycle bionutrients—carriers that feed the energy producing system in the body—including malates, ascorbates, aspartates, sebacates, citrates, and glycinates. Thus, we use magnesium malate, and calcium ascorbate and citrate. The whole point is that the body immediately recognizes and utilizes these forms.

In practice, Dr. Hank’s inclusion of the most absorbable forms and carriers means you actually absorb and assimilate more of the ingredients—whether vitamins, minerals, cofactors, antioxidants, herbs, or Nrf2 activators—than you would from the same old conventional forms and carriers (oxides, for example) found in many multivitamins, especially “off-the-shelf” or “one-a-day” type formulas. Many so-called “boutique” formulas use conventional forms and carriers. Who knew!?

To top it off, many advanced ingredients in Mighty Multi-Vite! (like Nrf2 activators) are nowhere to be found in the vast majority of multivitamins. You might not even know to look for them!

However, the biggest benefit of the science behind Mighty Multi-Vite! is how you feel when taking it. I really feel the difference. Your multivitamin should work for you and support your best health. If your multivitamin is not giving you what you need—or you can’t feel the difference it makes in your life—then why take it? Maybe it is better than nothing, but why settle for less when better options are available?

The single biggest reason I am a huge fan of Mighty Multi-Vite! is because I have taken it for more than 20 years. I have gained all the benefits it offers—for thousands of days—year after year. I am more than confident in its superior benefits not just for me, but because I have seen many other people gain benefits, and heard countless positive testimonies from happy customers. I know you can gain major benefits from it, too.

But wait, there’s more! Read the overview (below) for some nitty, gritty details distinguishing Dr. Hank’s design of Mighty Multi-Vite!. These not-so-little details can make all the difference for your good health.Mighty Multi-Vite multivitamin supplement


COMPLETE, BALANCED ESSENTIAL NUTRITION – Provides a full spectrum of nutrients exceptionally well balanced for creating and maintaining optimal heatlh. Mighty Multi-Vite! offers all of the most important vitamins along with minerals, cofactors, antioxidants, herbs, and Nrf2 activators.

RAPID, EASY ASSIMILATION – Incorporates the most bioavailable vitamin and mineral carriers most easily recognized and rapidly assimilated by your body. In addition, the formula uses multiple forms of mineral carriers to ensure assimilation. In addition, the capsule form (compared to tablets) speeds uptake because it does not require time for the body to break it down.

ENERGIZING – Includes coenzyme form vitamins and Krebs Cycle bionutrients that work with your body to create super high energy levels. Provides significantly higher levels of B vitamins than most multivitamins (especially coenzyme B vitamins). These vitamins are known for boosting energy, supporting the body during times of stress, and supporting nerve, heart, brain and immune system function.


• A full-spectrum of B-complex vitamins, most in coenzyme forms, as well as more conventional forms. Includes Vitamin B1 as thiamin HCl, Vitamin B2 as riboflavin and riboflavin-5’-phosphate, Vitamin B3 as niacinamide and niacin, Vitamin B5 as pantothenic acid, Vitamin B6 as pyridoxine HCl and pyridoxal-5’-phosphate, folate as L-5-methyltetrahydrofolate calcium (L-5-MTHF), Vitamin B12 as methylcobalamin, and biotin

• All of the most absorbable and usable forms of the fat-soluble vitamin group, including Vitamin A (as alpha & beta-carotene), Vitamin E (as d-alpha tocopherol succinate), Vitamin D3 (as cholecalciferol), and Vitamin K (as phytonadione (K1) and MK-7 (menaquinone-7) (K2))

• A complete and balanced supply of the most abundant carotenoids found in the body, including beta-carotene, alpha-carotene, lycopene and lutein

• A variety of the best-known herbal preparations, including whole grape extract (seeds, pulp, skin), turmeric (95% curcuminoids), broccoli sprouts powder, and octacosanol (from rice bran)

• All of the known essential minerals in forms readily absorbed and recognized by the body including calcium, magnesium, potassium, zinc, manganese, boron, copper, chromium, molybdenum, vanadium, and selenium

• Mineral carriers such as ascorbates, Krebs cycle bionutrients, and amino acids providing the body with important metabolic substrates and vitamins, including citrate, succinate, malate, glycinate, aspartate, sebacate, and Vitamin C

• Contains a wide range of antioxidants and Nrf2 activators including Buffered Vitamin C, Vitamin A, Vitamin E, Carotenoids, NAC, whole grape extract, curcuminoids, and broccoli sprouts

• Includes N-Acetyl-L-Cysteine (NAC), an important sulfur-containing amino acid supporting the body’s antioxidant and detoxification systems, and betaine HCl to support digestive processes

• Includes Choline and inositol which play a crucial role in all the cell membranes of the body, in brain function, and in liver function

• Includes Nrf2 transcription factor activators (i.e., Nrf2 activators), which are nutrients that direct cells to produce their own antioxidants, making your body an antioxidant production machine. Most multivitamins contain few, if any Nrf2 activators. Mighty Multi-Vite! is one of the few multivitamins whose design intentionally provides Nrf2 activators.

• Exclusion of the prooxidant minerals of iron and iodine which can lead to excessive free-radical production and PABA that sometimes adversely affects brain function in some individuals. (Note: we sell iodine formulas separately.)

• Capsule form ensures maximum absorption of ingredients

• Four-per-day full dosage allows for partial dosing for children, seniors, and pets

• Vegetarian formula (including capsule) suitable for vegetarians and vegans

• Exclusion of ingredients such as wheat, dairy, corn, soy, gluten, and egg having well-known antigenic properties and that may be associated with allergy or delayed hypersensitivity reactions

• A minimum of excipients, fillers, lubricants, etc. having deleterious effects in some individuals

• NON-GMO (no genetically modified organisms)


Most people don’t think too hard about their multivitamins. They focus on taking the supplement de jour (whatever supplements make headlines) or continue taking the same one-a-day multivitamin.

That is too bad because a multivitamin truly is the single most important nutritional supplement. We at HPDI place the multivitamin first—above all other supplements—in importance. Our Foundational Supplements system starts with a multivitamin because it is the only formula designed to provide the basic nutrients essential for health. That is, you can add other essential nutrients (like vitamin C or essential fats) to complete your regimen. But the multivitamin remains king (or queen) because it establishes your baseline nutrient intake. That is something is to consider when selecting the multivitamin you will take daily for the rest of your life.

Ask yourself: Is my multivitamin complete, providing all the most important nutrients I need for health? Is it easily absorbed using multiple, readily assimilated forms and usable carriers of those nutrients? Is it proven to work? Is it easy to take? Do I notice the effects?

If you answer “no” to any of these questions, or if you simply never think about it, then consider Hank & Brian’s Mighty Multi-Vite!. You should love your multivitamin because of how it supports your health. We think you will love Mighty Multi-Vite!.


Hank & Brian’s Mighty Multi-Vite!

HPDI Multivitamins

Foundational Supplements


HPDI YouTube Channel

Foundational Supplements video


Rejuvenation Program: Part Four


Fred Liers PhD rejuvenation programThe HPDI Rejuvenation Program provides practices, protocols, and recommendations proven over 31 years. It is a complete program to rejuvenate, regenerate, and boost vitality to body, mind, and spirit. It is especially helpful for those who want to restore health.

The program emphasizes establishing basic nutrition, foundational nutritional formulas, and high-RNA Rejuvenate!™ superfoods and other sources of dietary nucleic acids. The program rests on six elements: 1) Attitude/Commitment, 2) Detoxification, 3) Preventing Toxicity, 4) Health Building Nutrition, 5) Building Powerful Immunity, and 6) Supporting Protocols.

The six foundational elements remain powerful individually, but act synergistically when combined to support optimal health. The results are greatly improved capabilities for your body to heal, regenerate, rejuvenate, and restore its vitality.

As I stated in Part Three of the Rejuvenation Program series, health building nutrition plays a major role in the process of rejuvenation. We recommend emphasizing organic and/or wildcrafted foods, consuming more plant-based foods, raw foods, and generally consuming natural, whole foods (e.g., avoiding refined/processed foods).

I also discussed foods recommended in our Rejuvenation Program. Our recommendations include consuming foods high in nucleic acids (RNA and DNA). RNA-rich foods include chlorella and  Rejuvenate!™ superfoods. Rejuvenate! superfoods provide therapeutic levels of nucleic acids to support optimal rejuvenation, revitalization, and health. They also provide supporting nutrients (e.g., d-ribose, coenzyme B vitamins) that maximize utilization and healing effects of dietary nucleic acids in the body.

HPDI offers three versions of Rejuvenate!, including Rejuvenate! (original greens)Rejuvenate PLUS, and Rejuvenate! Berries & Herbs. Rejuvenate! PLUS and Rejuvenate Berries & Herbs are the most complete. Both provide delicious taste, therapeutic levels of dietary RNA, nutrients that support the body’s use of nucleic acids (e.g., d-ribose), a complete multivitamin, essential fats, and high levels of protein.


Last month, I discussed dietary/food aspects of nutrition. Today, I present key roles played by what we call “foundational” (or sometimes “core”) nutritional supplements. Foundational nutritional supplements are one of the critical means to success in creating powerful health by establishing optimal nutrient status in the body. Foundational supplements include: 1) multivitamins, 2) An antioxidant / Vitamin C formula, 3) essential fats, and 4) high-RNA superfoods.

We have found that proper nutritional supplementation provides important nutrients not always easily available in the diet. This partly relates to the fact that our needs for nutrients have never been greater. In addition, there are various reasons that most foods are deficient in nutrients, and therefore cannot or do not provide levels of nutrients required to sustain optimal health.

Some reasons dietary supplements are necessary include the fact that most crops are grown in nutrient-deficient or depleted soils; increased demands by the body due to greater needs for nutrients (relating to detoxification, stress, pollution, etc.); biochemical individuality resulting in greater needs for certain nutrients depending on the biochemistry unique to individuals. Biochemical individuality means that a person may require many times the US Daily Value of specific nutrients. In fact, one person may need hundreds of times the amount of a nutrient compared to a different person.

In addition, needs change during the year due to environmental circumstances. Changing seasons, environments, air/water supply, etc. mean that an individual’s need for nutrients typically changes during the year (e.g., more vitamin D needed in the winter, more nutrients needed to deal with pollution associated with urban environments or stress, etc.). Nutrient density of foods also varies by location, season, etc. The availability of nutrients in foods (even organically grown foods) can vary substantially due to season, geography, growing methods, etc.

All these factors add up to the fact that it is difficult to ensure optimal nutrient status without supplementation. Because the need for nutrients is greater than ever for most people, the need for nutritional supplementation is also greater than ever. Nutritional supplements provide an effective (and cost effective) means to ensure the high levels of nutrients required to build, sustain, and maintain optimal health.



Foundational formulas are the primary supplements we recommend for success not only in our Rejuvenation Program, but also for helping create better health generally. In fact, foundational supplement formulas are the basic building blocks for establishing and maintaining high nutritional status at all times in any program. (While foods are your primary source of nutrients, nutritional supplements are the best way to ensure intake of nutrients needed for good health.)

As noted above, the four foundational nutritional supplements we recommend are: 1) a high-potency multivitamin, 2) an essential fats formula (omega-3 and omega-6), and 3) Vitamin C (preferably buffered) with antioxidants (especially bioflavonoids), and 4) Rejuvenate!™ superfoods (and/or other high-RNA superfoods).

These four types of foundational formulas are the most important supplements and superfoods. Even if you take no other dietary supplements, these are the formulas that ensure you get basic nutrients required for good health. In fact, no diet or nutritional supplementation program is complete without them.

I will now consider the four types of foundational formulas, explain how they function, and reasons why they essential for good health.


A high-quality, high-potency multivitamin is the single most important supplement you can take. A good multivitamin ensures you receive important nutrients not always available in optimal amounts in foods. Taking a multivitamin helps guarantee uptake of nutrients that ar e not readily available because modern diets have strayed far from traditional diets. In addition, modern lifestyles create far greater demands for critical nutrients even as many nutrients are increasingly less available from foods. Multivitamins help break the cycle of deficiency and degeneration.

Critical nutrients provided by a good therapeutic multivitamin formula include a wide range of essential vitamins, minerals, and cofactors. Such a formula will usually include trace minerals, fat-soluble vitamins (A, E, D, & K), coenzyme B vitamins, magnesium, or other nutrients known to be deficient in the diets of most individuals.

Important factors to consider when looking for a good multivitamin, include high-potency, forms, completeness, balance, assimilability (e.g., ease of uptake and rapid assimilation), ease of use (convenience), etc.

High-potency is important because for most nutrients, the so-called “daily value” is simply inadequate for most people. Most individuals need many times the daily value of vitamins for good health. This is because daily values are established based on minimum amounts required for sustain life (e.g., survival) rather than the optimal amounts needed for good health.

As noted, studies of biochemical individuality show that individuals may require many times greater amounts of specific nutrients than are needed by the average person. Because most vitamins (especially water soluble ones) are essentially non-toxic even in relatively large doses (i.e., hundreds or sometimes thousands of times the daily value), it pays to provide your body with larger amounts of critical nutrients that it may require because you may not be an ‘average’ person.

Complicating this picture is the fact that individuals needs for specific nutrients vary widely. Thus, for example, one person’s need for vitamin C may be somewhat higher than average, yet the same person’s need for vitamin D may be significantly higher than average.

The proper forms of the nutrients are another critical factor. While forms have not always been a prime consideration (either of consumers or formulators), they are critically important. Forms are worthy of attention because we know that the form of a vitamin or mineral can make a major difference in terms of how it assimilated and used in the body.

For example, Krebs cycle bionutrients (i.e., mineral carriers, such as citrates, malates, alpha-ketoglutarates, succinates, or fumarates) are known to be superior precisely because they are the forms naturally recognized and utilized in the body. This is because these forms are used in the Krebs cycle (or citric acid cycle) that is part of the metabolic pathway used to generate energy (ATP) from nutrients in foods. In contrast, elemental forms of minerals and/or forms that are not part of the Krebs cycle may be more difficult to assimilate because they must be converted into forms the body can use. The biological cost is reduced bioavailability, as well as cellular energy expense and time required for metabolic conversion. As you can see, forms matter for health!

Other important factors include completeness and balance. Completeness is important in a multivitamin because the body requires a wide range of nutrients working together to create and sustain health. Many multivitamins are neither complete nor balanced. This relates partly to the fact that multivitamins are often not designed with an understanding of nutrients, forms, or amounts needed for health. Consequently, many commonly available multivitamins incorporate less effective forms, inadequate amounts, and improper ratios of nutrients. This reflects a general lack of understanding by formulators about how nutrients work together to build and sustain health. In contrast, supplements are available that provide completeness and balance.

HPDI offers several high-quality, balanced, and complete multivitamins providing easily assimilated forms of nutrients in optimal amounts. These include Hank & Brian’s Mighty Multi-Vite!, Multi Two caps or tabs, and Chewable Kids Mighty-Multi! (which is also designed for adults to enjoy, too). We recommend our capsule formulas because they are the easier to assimilate. However, our tablet formulas are both effective and cost-effective. Children benefit greatly from a multivitamin, and for them we offer our chewable Kids Mighty-Multi! multivitamin formula.


Vitamin C is legendary for its healing capacities. Yet, it is notable that despite numerous studies and accolades by nutritionists, it remains underutilized by mainstream medicine and is completely under-appreciated for the healing powerhouse it represents for human health.

We include Vitamin C as a foundational formula because we understand its role in creating and sustaining optimal health. Vitamin C not only is a potent antioxidant, but also a powerful immune builder/anti-viral, cholesterol controller, and connective tissue strengthener. In fact, no other vitamin or nutrient can take its place in terms of what it can contribute to human health, longevity, and well-being.

Ever since Linus Pauling wrote Vitamin C and the Common Cold, Vitamin C has held a place of esteem among nutritional scientists and consumers of Vitamin C products. Pauling went on to present further studies and to write his best-seller How to Live Longer and Feel Better (rev. 2006). Vitamin C plays a major role both in his discussion of vitamins and in the supplement regimens he recommends.

In nature, Vitamin C is always combined with bioflavanoids. Bioflavanoids (such as rutin, quercetin, catechins, anthocyandins, and oligomeric proanthocyanidins (OPCs)), work synergistically with Vitamin C to create powerful antioxidant effects, counteract inflammation, and strengthen connective tissues. In addition, Vitamin C and bioflavanoids combine with other antioxidants (including glutathione, lipoic acid, and selenium) in a process called “redox cycling.” In this process, antioxidants protect and “spare” each other, thereby allowing for significantly increased antioxidant protection in the body.

We offer a variety of Vitamin C products, including formulas with bioflavonoids. Our Vitamin C formulas include Ultimate Protector+™, PRO-C™, Buffered Vitamin C tabs, and Buffered Vitamin C powder. We typically recommend taking a buffered Vitamin C product to prevent acidosis and help maintain proper pH levels in the body.

We consistently find that one of greatest means for success in creating health using dietary supplements is to ensure you take all four types of foundational formulas. For example, many people take one or two foundational formulas: a multivitamin, essential fats, Vitamin C plus bioflavonoids, and/or high-RNA superfoods. But how many people take all four daily? Do you take all four daily? You might be surprised at the results if you took them all daily. This is because foundational formulas work together synergistically and leverage each other in ways that exceed the health-building effects that can be expected when foundational formulas are taken individually.


Many people understand the need to take supplemental multivitamins. The need for essential fatty acids (EFAs) has gained increased attention recently, and it is no less important. More people are consuming fish, fish oils, and vegetarian sources of essential fats, including chia seeds. However, the need for supplementing diet with essential fats to ensure adequate daily intake has never been greater than today.

There are two basic essential fats: alpha-linoleic acid (omega-3) and linolenic acid (omega-6). Other fats are sometimes included as being essential fats, including gamma-linolenic acid (GLA), an important omega-6 fatty acid, and eicosapentanoic acid (EPA) and docosahexanoic acid (DHA), important omega-3 fatty acids.

Essential fats are considered ‘essential’ because they are needed for biological processes (i.e., they are required to sustain life) rather than acting only as a food-based source of energy (as do many other non-essential fatty acids). Humans, therefore, must ingest essential fatty acids both for survival and for good health.

Essential fats play multiple roles in the body and serve many different functions. These functions include being modified to make eicosanoids (affecting pain and inflammatory processes); regulating steroid production and hormone synthesis; regulating pressure in the eyes, joints and blood vessels; mediating the immune response; regulating smooth muscle and autonomic reflexes; are needed for oxygen transport from red blood cells to tissues; are necessary for kidney function and fluid balance; preventing clumping of red blood cells; regulating mood and depression, and regulating nerve transmission.

Every cell and organelle within the cells are encased and protected by membrane made of phospholipids. A major component of these phospholipids are essential fatty acids that control membrane fluidity and the ability to pass important nutrients into the cells and toxins out of the cells. Without adequate essential fats the cell membranes can become rigid and dysfunctional.

We offer an essential fats product, called Hank & Brian’s Essential Fats Plus E. This product contains EPA and DHA from highly purified fish oils, GLA from cold-processed borage oil, and full spectrum Vitamin E consisting of all eight natural forms of tocotrienols and tocopherols. These mixed forms of Vitamin E perform many beneficial functions in the body (such as lowering cholesterol and clearing plague out of blood vessels) and also protect the essential fats from oxidizing in the capsule and in your body. The ratio of EPA to GLA in this products is 4:1, which is considered the ideal ratio for optimal effects in the body.


Our recommendations for foundational formulas now include high-RNA superfoods. We first recommend a multivitamin, an antioxidant / Vitamin C formula, and essential fatty acids. After these three foundational formulas are established in a daily regimen, the addition of a high-RNA superfood further contributes to excellent health.

We include high-RNA superfoods (and especially recommend Rejuvenate!™ superfoods) in our foundational supplements program after having studied the remarkable healing powers of chlorella and other high-RNA nutrients for six years. When taken in sufficient amounts, superfoods high in ribonucleic acid (RNA) show remarkable effects in the body. These effects include higher energy levels, greater endurance, better muscle strength, easier breathing, lower cholesterol levels, reductions in angina pains (and other positive cardiovascular effects), more stable blood sugar, better vision, and a more youthful appearance (smoother skin, fewer wrinkles, etc.), and many other benefits.

Our assessment of dietary nucleic acids being essential nutrients is shared by scientists on the cutting-edge of nutrition. In Nucleic Acid Nutrition and Therapy, Dr. Benjamin S. Frank asserts that dietary nucleic acids (RNA, DNA) are “essential nutrients of human beings” as distinct from non-essential, accessory nutrients. He considers nucleic acids and nucleotides an essential dietary category, i.e., as being nutrients “just as essential for humans as vitamins, minerals, proteins, carbohydrates, and lipids” (Frank).

After having studied the positive health effects of dietary RNA in the clinic for more than 20 years, Dr. Frank asserted:

“[N]ucleic acids are an essential nutrient in our daily diets, and […] optimal health and reduced aging are clearly related to their intake, more than to any other nutrient. Nucleic acids in our diets are of paramount importance for the repairing of molecular and gross tissue degeneration, and for combating the process of aging by simple, effective and essentially non-toxic, natural means.”

Dr. Frank’s conclusion that RNA is more essential to health than any other single nutrient underscores the central role of nucleic acids for human health.

We share Dr. Frank’s conclusions regarding the “essential” nature of nucleic acids and nucleotides, and their central role in human health. In fact, it is our direct experience with the health-building effects of dietary nucleic acids (e.g., in chlorella and other foods) that led to further our knowledge of nucleic acid nutrition and therapy, and develop our line of high-RNA Rejuvenate!™ superfoods. Rejuvenate!™ superfoods both provide optimal levels of nucleic acids and include supporting nutrients (e.g., d-ribose, coenzyme B vitamins), which maximize the beneficial effects of dietary RNA for health.

The nucleic acids in Rejuvenate!™ superfoods work directly with HPDI’s other foundational nutritional supplements to create, sustain, and support optimal nutrition for health and healing. We recommend Rejuvenate!™ and/or other high-RNA superfoods as part of program of foundational nutritional supplements that work together to provide full spectrum nutrition. It is because foundational formulas provides a full spectrum of essential nutrients that it is critical to success in our Rejuvenation Program, and to create, maintain, and/or rebuild health.


The best news with respect to dietary nucleic acids is that while they are essential nutrients, their inclusion in our foundational supplement program powerfully leverages their effects by facilitating greater synergy among all nutrients available to the body via foundational supplements. This synergy means the total package of nutrients delivered by all four types of foundational supplements combined delivers far more health-building nutrition than any single foundational formula delivers individually. That’s synergy in action.

The means by which all four foundational supplements succeed in creating and contributing to powerful health relates less to the fact that each singly provides an ‘essential’ piece of the nutrition puzzle. Success relates instead to the fact that when all foundational formulas are taken together, their healthy benefits multiply and greatly exceed the sum of benefits provided by individual foundational formulas. This is a primary reason we emphasize establishing foundational nutrition both within our Rejuvenation Program, and more generally as a starting point for the creation of powerful health.



Dr. Hank Liers, PhD natural nrf2 activators healing potential

When I first learned about Nrf2 activators in early 2012, I became quite enthusiastic about new knowledge that natural substances called polyphenolic compounds had the ability to activate this transcription factor. Once released in the cell Nrf2 can migrate to the nucleus and cause the body to endogenously produce high levels of key protective/antioxidant enzymes.

Also, I actively began the development of a product called Ultimate Protector that contains many concentrates and extracts from fruits, vegetables, and herbs. This product functions as 1) an excellent source of many Nrf2 activators, 2) a source of powerful antioxidants exhibiting an extremely high ORAC5.0 value per serving, and 3) a source of non-GMO Vitamin C.

More recently (July 2019) I have updated the product to Ultimate Protector+ that contains some exciting new ingredients that are now available on the market including SFB® (Standardized Fruit Blend) that contains among others mangosteen, goji berry, pomegranate, and apple extracts (click on the ingredient name to see detailed blog articles concerning these). In addition, I have added significant amounts of ingredients that are well known as potent Nrf2 activators and antioxidants including Green Tea extract and VinCare® whole grape extract.


Ultimate Protector+

New Ultimate Protector+


It is interesting to note that over 16 years ago I formulated a wonderful antioxidant formula called PRO-C™. PRO-C™ contains Buffered Vitamin C (in the form of powdered calcium, magnesium, and zinc ascorbates), high-potency Grape Extract (from grape pulp, skins, and seeds), Green Tea Extract, reduced Glutathione, N-Acetyl-L-Cysteine (NAC), R-Lipoic Acid, coenzyme forms of Vitamin B2 and Vitamin B6, and Selenium.

PRO-C™ has been one of the most effective products at supporting health I have ever formulated. Our current knowledge shows that PRO-C™ contains four effective Nrf2 activators, selenium needed for glutathione peroxidase functioning, Vitamin B2 and Vitamin B6 that support the effectiveness of glutathione, and antioxidants including Vitamin C and glutathione. I recently wrote a blog article titled PRO-C™ SUPER ANTIOXIDANT FORMULA that provides details concerning this formula.

My current personal list of supplements that I (and my wife) take every day includes both Ultimate Protector+™ and PRO-C™. We feel gifted to have these products available to us!!

In this article, I will provide greater insight into the natural sources of Nrf2 activators and how they perform in the body.


Activation of Nrf2 results in the induction of many cytoprotective proteins. We have seen articles that claim over 200 different enzymes can be produced in the body by Nrf2 activators, but have also seen reference that over 4,000 enzymes may be produced!  Examples of some of the key enzymes are shown below:

  • NAD(P)H quinone oxidoreductase 1 – a prototypical Nrf2 target gene that catalyzes the reduction and detoxification of highly reactive quinones that can cause redox cycling and oxidative stress.
  • Superoxide dismutases (SOD) – enzymes that catalyze the dismutation of superoxide (O2) into oxygen and hydrogen peroxide. Thus, they are an important antioxidant defense in nearly all cells exposed to oxygen where superoxide is one of the main reactive oxygen species. SOD is known to provide powerful antinflammatory activity.
  • Glutamate-cysteine ligase which is the rate-limiting step in the synthesis of glutathione (GSH), a very powerful endogenous antioxidant. Glutamate-cysteine ligase is a characteristic Nrf2 target gene, which establishes Nrf2 as a regulator of glutathione, one of the most important antioxidants in the body.
  • Heme oxygenase-1 (HO-1) is an enzyme that catalyzes the breakdown of heme into the antioxidant biliverdin, the anti-inflammatory agent carbon monoxide, and iron. HO-1 is a Nrf2 target gene that has been shown to protect from a variety of pathologies, including sepsis, hypertension, atherosclerosis, acute lung injury, kidney injury, and pain.
  • The glutathione S-transferase (GST) family includes cytosolic, mitochondrial, and microsomal enzymes that catalyze the conjugation of GSH with endogenous and xenobiotic electrophiles. After detoxification by GSH conjugation catalyzed by GSTs, the body can eliminate potentially harmful and toxic compounds. GSTs are induced by Nrf2 activation and represent an important route of detoxification.
  • The UDP-glucuronosyltransferas (UGT) family catalyze the conjugation of a glucuronic acid moiety to a variety of endogenous and exogenous substances, making them more water soluble and readily excreted. Important substrates for glucuronidation include bilirubin, and acetaminophen. Nrf2 has been shown to induce UGT1A1 and UGT1A6.
  • Multidrug resistance-associated proteins  (Mrps) are important membrane transporters that efflux various compounds from various organs and into bile or plasma, with subsequent excretion in the feces or urine, respectively. Mrps have been shown to be upregulated by Nrf2 and alteration in their expression can dramatically alter the pharmacokinetics and toxicity of compounds.


The March 2011 Epub Biochemical Basis for Functional Ingredient Design from Fruits reports: “Functional food ingredients (nutraceuticals) in fruits range from small molecular components, such as the secondary plant products, to macromolecular entities, e.g., pectin and cellulose, that provide several health benefits.  In fruits, the most visible functional ingredients are the color components anthocyanins and carotenoids.

“In addition, several other secondary plant products, including terpenes, show health beneficial activities.  A common feature of several functional ingredients is their antioxidant function. For example, reactive oxygen species (ROS) can be oxidized and stabilized by flavonoid components, and the flavonoid radical can undergo electron rearrangement stabilizing the flavonoid radical.  Compounds that possess an orthodihydroxy or quinone structure can interact with cellular proteins in the Keap1/Nrf2/ARE pathway to activate the transcription of antioxidant enzymes.

“Carotenoids and flavonoids can also exert their action by modulating the signal transduction and gene expression within the cell. Recent results suggest that these activities are primarily responsible for the health benefits associated with the consumption of fruits and vegetables.”

One of the interesting aspects of the extensive research that has been conducted is the fact that many of the polyphenols that have been shown to activate Nrf2 have been used in natural healing formulas for many years. For example, an article in a November 2010 production titled Nutraceutical antioxidants as novel neuroprotective agent expands on the classes of “antioxidant” compounds that are neuroprotective and operate either via direct antioxidant action or via the keap1-Nrf2 pathway:

“A variety of antioxidant compounds derived from natural products (nutraceuticals) have demonstrated neuroprotective activity in either in vitro or in vivo models of neuronal cell death or neurodegeneration, respectively. These natural antioxidants fall into several distinct groups based on their chemical structures: (1) flavonoid polyphenols like epigallocatechin 3-gallate (EGCG) from green tea and quercetin from apples; (2) non-flavonoid polyphenols such as curcumin from tumeric and resveratrol from giant knotweed and grapes; (3) phenolic acids or phenolic diterpenes such as rosmarinic acid or carnosic acid, respectively, both from rosemary; and (4) organosulfur compounds including the isothiocyanate, L-sulforaphane, from broccoli and the thiosulfonate allicin, from garlic.

“All of these compounds are generally considered to be antioxidants.  They may be classified this way either because they directly scavenge free radicals or they indirectly increase endogenous cellular antioxidant defenses, for example, via activation of the nuclear factor erythroid-derived 2-related factor 2 (Nrf2) transcription factor pathway. Alternative mechanisms of action have also been suggested for the neuroprotective effects of these compounds such as modulation of signal transduction cascades or effects on gene expression. Here, we review the literature pertaining to these various classes of nutraceutical antioxidants and discuss their potential therapeutic value in neurodegenerative diseases.”


One of the ways dietary flavonoids work to confer their multiple health effects is via the keap1-Nrf2 pathway.  That is substances which are both themselves antioxidants and activators of the keap1-Nrf2 pathway produce significant results through keap1-Nrf2 and activating the body’s own antioxidant and defensive systems.

Flavonoids are a large family of polyphenolic compounds synthesized by plants. Many of the common dietary flavonoids are shown in Table 1 below along with their common food sources.

Table 1: Common Dietary Flavonoids

Flavonoid Subclass Dietary Flavonoids Some Common Food Sources
Anthocyanidins  Cyanidin, Delphinidin, Malvidin, Pelargonidin, Peonidin, Petunidin Red, blue, and purple berries; red and purple grapes; red wine
Flavonols  Monomers (Catechins) Catechin, Epicatechin, Epigallocatechin, Epicatechin gallate, Epigallocatecin gallate Dimers and Polymers: Theaflavins, Thearubigins, Proanthocyanidins Catechins: Teas (particularly green and white), chocolate, grapes, berries, apples Theaflavins, Thearubigins: Teas (particularly black and oolong) Proanthocyanidins: Chocolate, apples, berries, red grapes, red wine.
Flavanones Hesperetin, Naringenin, Eriodictyol Citrus fruits and juices, e.g., oranges, grapefruits, lemons.
Flavonols Quercetin, Kaempferol, Myricetin, Isorhamnetin Widely distributed: yellow onions, scallions, kale, broccoli, apples, berries, teas.
Flavones Apigenin, Luteolin Parsley, thyme, celery, hot peppers.
Isoflavones Daidzein, Genistein, Glycitein Soybeans, soy foods, legumes.

In addition to flavonoids many other plant based substances appear to produce health benefits through hormetic effects mediated by Nrf2.  The December 2011 publication Nutritional antioxidants and adaptive cell responses: an update reports: “Many plant antioxidants, intaken through the daily diet or plant-derived dietary supplements, have been shown able to prevent free radical-related diseases by counteracting cell oxidative stress. However, it is now considered that the in vivo beneficial effects of these phytochemicals are unlikely to be explained just by their antioxidant capability.

“Several plant antioxidants exhibit hormetic properties, by acting as ‘low-dose stressors’ that may prepare cells to resist more severe stress. In fact, low doses of these phytochemicals activate cell signaling pathways (being the most prominent examples the modulation of the Nrf2/Keap1 pathway, the NF-κB pathway and the Sirtuin-FOXO pathway) but high doses are cytotoxic.

“Herein we review the adaptive responses induced by the most known plant hormetic antioxidants, which are sulforaphane, resveratrol, curcumin, flavonoids, green tea catechins and diallylsulphides [in garlic], as well as the molecular mechanisms involved in such responses. Furthermore, this review outlines that the hormetic properties of these bioactive plant antioxidants might be successfully employed for realizing health-promoting dietary interventions especially in the field of neurodegenerative diseases and cancer.”


Ultimate Protector+


1) An interesting fact is that Nrf2 is ubiquitously expressed with the highest concentrations (in descending order) in the kidney, muscle, lung, heart, liver, and brain. 

2) Another important fact is that the well-known nutrition supplement lipoic acid is a potent activator of Nrf2 and thus increases Gluthatione levels, which may explain its protective effect against diabetic co-morbidities. Additionally, the nutritional supplements tocotrienols (active forms of Vitamin E) and N-Acetyl-L-Cysteine (NAC) are also effective Nrf2 activators!

3) We have observed that the natural plant substances with the highest ORAC5.0 values appear to be among the most effective Nrf2 activators. For example, see the table below. In particular, note that Curcumin (98%), Grape Seed Extract, Green Tea Extract, and Reservatrol which are commonly used for their excellent Nrf2 activator effects are the most powerful in-vitro antioxidants . Please note that Ultimate Protector+ is over 100% more powerful as an antioxidant than the best single plant ingredient.


Ingredient Peroxyl Radical Hydroxyl Radical Peroxy-nitrite Radical Super-
oxide Radical
Singlet O2 Radical Total ORAC5.0
Curcumin 98% 5,750 8,920 906 597 66,290 82,500
Bilberry 25% 7,000 25,000 1,000 16,000 5,000 54,000
Cocoa 10,000 28,000 1,000 11,000 2,000 52,000
Grape Seed Extract 17,000 47,000 1,000 25,000 4,000 94,000
Green Tea Extract 11,000 41,000 2,000 56,000 3,000 113,000
Coffee Berry Extract 5,000 29,000 1,000 1,000 2,000 38,000
Mangosteen 4,000 8,000 1,000 18,000 4,000 35,000
Pine Bark 7,000 23,000 1,000 17,000 2,000 50,000
Resveratrol 12,000 50,000 1,000 8,000 22,000 93,000
ULTIMATE PROTECTOR+    3,376    5,569 2,758 221,866 34,169 267,738
Results are expressed in micro mole TE/g

The total Ultimate Protector+ ORAC5.0 value per serving of 6 small vegetarian capsules (containing 3.55 g) is over 950,00 Micro mole TE.

4) Here is a list of the ingredients in ULTIMATE PROTECTOR+: USP-grade non-GMO Vitamin C, SFB® standardized fruit blend (~50% polyphenols, high-ORAC powder: 9,000 µmole TE/g) from Grape, Cranberry, Pomegranate, Blueberry, Apple, Mangosteen, Bilberry, Chokeberry, and Goji Berry), Curcumin (standardized extract with 95% curcuminoids), Trans-Resveratrol (98% from Giant Knotweed), Green Tea Extract (93% polyphenols, 50% EGCG), VinCare® Whole Grape Extract (>80% polyphenols, ORAC>19,000 µmole TE/g), Calcium Malate, Magnesium Malate, and Bioperine® (a patented black pepper extract that enhances absorption of all ingredients and is a known Nrf2 activator).


Below are two abstracts that discuss how modulation of the Nrf2/ARE pathway by food polyphenols can provide neuroprotection through the activation of the heme-oxygenase enzyme.

Modulation of Nrf2/ARE pathway by food polyphenols: a nutritional neuroprotective strategy for cognitive and neurodegenerative disorders. (Oct. 2011)


In recent years, there has been a growing interest, supported by a large number of experimental and epidemiological studies, for the beneficial effects of some phenolic substances, contained in commonly used spices and herbs, in preventing various age-related pathologic conditions, ranging from cancer to neurodegenerative diseases. Although the exact mechanisms by which polyphenols promote these effects remain to be elucidated, several reports have shown their ability to stimulate a general xenobiotic response in the target cells, activating multiple defense genes.

Data from our and other laboratories have previously demonstrated that curcumin, the yellow pigment of curry, strongly induces heme-oxygenase-1 (HO-1) expression and activity in different brain cells via the activation of heterodimers of NF-E2-related factors 2 (Nrf2)/antioxidant responsive element (ARE) pathway. Many studies clearly demonstrate that activation of Nrf2 target genes, and particularly HO-1, in astrocytes and neurons is strongly protective against inflammation, oxidative damage, and cell death. In the central nervous system, the HO system has been reported to be very active, and its modulation seems to play a crucial role in the pathogenesis of neurodegenerative disorders.

Recent and unpublished data from our group revealed that low concentrations of epigallocatechin-3-gallate, the major green tea catechin, induces HO-1 by ARE/Nrf2 pathway in hippocampal neurons, and by this induction, it is able to protect neurons against different models of oxidative damages. Furthermore, we have demonstrated that other phenolics, such as caffeic acid phenethyl ester and ethyl ferulate, are also able to protect neurons via HO-1 induction. These studies identify a novel class of compounds that could be used for therapeutic purposes as preventive agents against cognitive decline.

The major green tea polyphenol, (-)-epigallocatechin-3-gallate, induces heme oxygenase in rat neurons and acts as an effective neuroprotective agent against oxidative stress. (Aug. 2009)


Oxidative stress induced by hyperglycemia is a key factor in the pathogenesis of diabetic complications, such as neuropathy. Recently, green tea catechins have received much attention, as they can facilitate a number of antioxidative mechanisms and improve glycemic control. The aim of this study was to investigate the cytoprotective effects of (-)-epigallocatechin-3-gallate (EGCG) against oxidative stress damage in a cell line of rat neurons. The role of heme oxygenase 1 (HO-1) induction by EGCG and the transcriptional mechanisms involved were also evaluated.

Immortalized rat neurons (H 19-7) were exposed to various concentrations of EGCG (10-200 microM). After treatments (6 or 24 hours), cells were harvested for the determination of heme oxygenase activity, mRNA levels, and protein expression. Nuclear levels of Nrf2, a transcriptional factor involved in HO-1 activation, were also measured. Neurons were pretreated for 12 hours with EGCG 50 microM or EGCG 50 microM + zinc protoporphyrin IX 10 microM and then exposed for 2 hours to 50 mmicro/mL glucose-oxidase before cell viability was determined.

In cultured neurons, elevated expression of HO-1 mRNA and protein were detected after 6 hours of incubation with 25-100 microM EGCG, and its induction relates with the activation of Nrf2. Interestingly, pre-incubation (12 hours) with EGCG 50 microM resulted in an enhanced cellular resistance to glucose oxidase-mediated oxidative damage; this cytoprotective effect was considerably attenuated by zinc protoporphyrin IX, an inhibitor of heme oxygenase activity.

In this study, we demonstrated that EGCG, the major green tea catechin, induced HO-1 expression in cultured neurons, possibly by activation of the transcription factor Nrf2, and by this mechanism was able to protect against oxidative stress-induced cell death.


The following review article abstract shows how natural products containing Nrf2 activator/antioxidant ingredients might be used to support health and anti-aging.

Nrf2/ARE Signaling Pathway: Key Mediator in Oxidative Stress and Potential Therapeutic Target in ALS (July 2012)


Abstract: Nrf2 (nuclear erythroid 2-related factor 2) is a basic region leucine-zipper transcription factor which binds to the antioxidant response element (ARE) and thereby regulates the expression of a large battery of genes involved in the cellular antioxidant and anti-inflammatory defence as well as mitochondrial protection. As oxidative stress, inflammation and mitochondrial dysfunctions have been identified as important pathomechanisms in amyotrophic lateral sclerosis (ALS), this signaling cascade has gained interest both with respect to ALS pathogenesis and therapy. Nrf2 and Keap1 expressions are reduced in motor neurons in postmortem ALS tissue.

Nrf2-activating compounds have shown therapeutic efficacy in the ALS mouse model and other neurodegenerative disease models. Alterations in Nrf2 and Keap1 expression and dysregulation of the Nrf2/ARE signalling program could contribute to the chronic motor neuron degeneration in ALS and other neurodegenerative diseases. Therefore, Nrf2 emerges as a key neuroprotective molecule in neurodegenerative diseases.

Our recent studies strongly support that the Nrf2/ARE signalling pathway is an important mediator of neuroprotection and therefore represents a promising target for development of novel therapies against ALS, Parkinson’s disease (PD), Huntington’s disease (HD), and Alzheimer’s disease (AD). Simultaneous blockage of disease-specific broad toxic signaling cascades in motor neurons and glia may ultimately lead to more efficient neuroprotection in ALS. Stimulation of defense mechanisms that modulate neuroprotective genes which affect both neuronal and glial functions is a novel therapeutic approach and holds great promise. A key molecule to affect a variety of defense mechanisms is the transcription factor Nrf2 which activates the Nrf2/ARE signaling program. Nrf2 acts as master regulator of the cellular antioxidant response by stimulation of over 250 phase II genes that should be referred to as “prolife genes” since they save cells from death.

Nrf2 activation can at once regulate the expression of multiple cytoprotective enzymes that are capable of simultaneous inhibition of major pathogenic pathways described in ALS such as oxidative stress, neuroinflammation, and mitochondrial dysfunction. Decreased Nrf2 expression was found in motor neurons in ALS postmortem brain and spinal cord. We have established the proof-of-concept that the Nrf2/ARE program is a viable target with excellent therapeutic potential for ALS. While there are still multiple gaps of knowledge on the path from Nrf2 dissociation to nuclear localization and its action as transcription factor, activation of the Nrf2 signaling cascade represents a novel and unique attempt to find a cure for ALS and other neurodegenerative diseases by fortifying the intrinsic defense mechanisms of neurons.


In this article I have shown how foods such as fruits, vegetables, herbs, and their extracts can stimulate extremely powerful protective enzymes in the body that work to keep us healthy. I strongly suggest that our readers eat an organic diet that emphasizes these foods and highly recommend the use of nutritional supplements such as Ultimate Protector+ and PRO-C™ that can further support the activation of the Nrf2 pathways in the body!







Dr. Hank Liers, PhD biography about us HPDI integratedhealth formulator founder CEO scientist physicist wild bilberry and wild blueberry

Ultimate Protector+ ingredients include pomegranate extract, as well as components from 12 different fruits, vegetables, and herbs. Each of these ingredients contain substances that may be considered to be polyphenols, antioxidants, and Nrf2 activators. In this article I will explore the ingredient pomegranate, which is a component of SFB® – Standardized Fruit Blend from Ethical Naturals, Inc.

Ultimate Protector+ Includes Pomegranate

Ultimate Protector+ Includes Pomegranate

SFB® – Standardized Fruit Blend

SFB® is a proprietary formula that combines extracts from Grape, Cranberry, Pomegranate, Blueberry, Apple, Mangosteen, Bilberry, Chokeberry, and Goji Berry. High in fruit polyphenols, anthocyanins, proanthocyanins, ellagic acid, chlorogenic acid, resveratrol, and quinic acid. With its diverse blend, SFB® offers over 40-50% polyphenols as well as 9,000 ORAC units in a single gram.

Polyphenols and Anthocyanins are powerful plant ingredients associated with a variety of areas of human health, including healthy aging, healthy glucose metabolism, cardiovascular health, and inflammation management.


The pomegranate (Punica granatum L.) is native from Iran to the Himalayas in northern India and was cultivated and naturalized over the whole Mediterranean region since ancient times. It is widely cultivated throughout India and the drier parts of southeast Asia, Malaya, the East Indies and tropical Africa. The tree was introduced into California by Spanish settlers in 1769.

For thousands of years, the pomegranate has been extensively used as a source of food and medicine. Full of antioxidants, vitamin C and potassium, pomegranate has been used to control body weight, reduce cholesterol, fight against cell damage, and inhibit viral infections. Pomegranate extracts have anti-bacterial effects.

Pomegranates are rich in ellagic acid, gallic acid, lignans, polyphenols and other bioactive compounds, and have been shown to lower blood pressure and enhance vascular function. Furthermore, it can offset some of the negative effects of medications and chemicals. These compounds occur naturally in its peel, seeds, leaf and juice. The seeds are high in p-coumaric acid, plant sterols, tannins and fatty acids. In addition to their antihypertensive effects, they may help reduce blood sugar levels.

Pomegranate fruit is a rounded berry with a thick reddish skin covering approximately 200–1400 white to deep red or purple seeds. Pomegranate seeds are edible and hold strong antioxidant and anti-inflammatory properties due to their high content of hydrolysable tannins and anthocyanins. As compared to the antioxidant activity of vitamin E, β-carotene, and ascorbic acid, the pomegranate antioxidants appear unique due to combinations of a wide array of polyphenols, having a broader range of action against several types of free radicals. As compared to the recognized antioxidants in red wine and green tea, anthocyanins from pomegranate fruit possess significantly higher antioxidant activity.

Pomegranate has been used in various medicinal systems of medicine for the treatment and therapy of a multitude of diseases and ailments. In the ancient Indian medicinal system, i.e., in Ayurvedic medicine, the pomegranate was considered to be a whole pharmacy unto itself. It was recommended to be used as an antiparasitic agent and to treat diarrhea and ulcers. The medicinal properties of pomegranate have sparked significant interest in today’s scientific community as evidenced by the scientific research relating to health benefits of pomegranate that have been published in last few decades.

Studies have shown that pomegranate and its constituents can efficiently affect multiple signaling pathways involved in inflammation, cellular transformation, hyperproliferation, angiogenesis, initiation of tumorigenesis, and eventually suppressing the final steps of tumorigenesis and metastasis. The pomegranate constituents are shown to modulate transcription factors, pro-apoptotic proteins, anti-apoptotic proteins, cell cycle regulator molecules, protein kinases, cell adhesion molecules, pro-inflammatory mediators, and growth factors.

Pomegranate Chemical Constituents

The pomegranate fruit consists of white to deep purple seeds embedded in a white spongy astringent membrane surrounded by a thick reddish skin, or pericarp. Pericarp constitutes almost 50% of the fruit weight and is a rich source of bioactive constituents, such as phenolics, flavonoids, ellagitannins, and proanthocyanidin compounds. It also contains various minerals, mainly potassium (K), nitrogen (N), calcium (Ca), phosphorus (P), magnesium (Mg), and sodium (Na), as well as complex polysaccharides. The remaining 50% of the fruit consists of seeds (constituting 10% of the fruit weight) and arils (constituting 40% of the fruit weight).

Pomegranate seeds hold strong antioxidant and anti-inflammatory properties due to the high content of hydrolysable tannins (punicalagin, pedunculagin, punicalin, gallagic acid, ellagic acid, and esters of glucose) and anthocyanins (delphinidin-3-glucoside, cyanidin-3-glucoside, delphinidin-3,5-diglucoside, cyanidin-3,5-diglucoside, pelargonidin-3,5-diglucoside, and pelargonidin-3-glucoside).

Various organic acids, such as ascorbic acid, citric acid, and malic acid, etc., are also reported to be present in the seed coat, while the arils contain water (85%), sugars (10%), mainly fructose and glucose, and pectin (1.5%). Arils are a rich source of bioactive compounds such as phenolics and flavonoids, principally anthocyanins.

Pomegranate seed oil consists of mainly conjugated linolenic acid. Interestingly, punicic acid, a conjugated isomer of linolenic acid found uniquely in pomegranate oil, constitutes 70%–76% of the seed oil. Sterols, steroids, and cerebroside, a key component of mammalian myelin sheaths, constitute the minor share of the seed oil.

Scientific Studies on the Antioxidant Effects of POMEGRANATE

Databases of scientific studies (like the National Institutes of Health (NIH) PubMed database) contain thousands of up-to-date studies and abstracts about pomegranate.

We provide a few relevant scientific studies on the antioxidant effects of pomegranate.

Adv Biomed Res. 2014; 3: 100.
Potent health effects of pomegranate
Authors: Aida Zarfeshany, Sedigheh Asgary,1 and Shaghayegh Haghjoo Javanmard


Accumulating data clearly claimed that Punica granatum L. (pomegranate) has several health benefits. Pomegranates can help prevent or treat various disease risk factors including high blood pressure, high cholesterol, oxidative stress, hyperglycemia, and inflammatory activities. It is demonstrated that certain components of pomegranate such as polyphenols have potential antioxidant, anti-inflammatory, and anti-proliferative effects. The antioxidant potential of pomegranate juice is more than that of red wine and green tea, which is induced through ellagitannins and hydrosable tannins. Pomegranate juice can reduce macrophage oxidative stress, free radicals, and lipid peroxidation. Moreover, pomegranate fruit extract prevents cell growth and induces apoptosis, which can lead to its anticarcinogenic effects. In addition, promoter inhibition of some inflammatory markers and their production are blocked via ellagitannins. In this article, we highlight different studies on the therapeutic effects of pomegranate and their suggested mechanisms of actions.

J Nutr Biochem. 2005 Jun;16(6):360-7.

In vitro antiproliferative, apoptotic and antioxidant activities of punicalagin, ellagic acid and a total pomegranate tannin extract are enhanced in combination with other polyphenols as found in pomegranate juice.
Authors: Seeram NP1, Adams LS, Henning SM, Niu Y, Zhang Y, Nair MG, Heber D.Seeram NP1, Adams LS, Henning SM, Niu Y, Zhang Y, Nair MG, Heber D.


Pomegranate (Punica granatum L.) fruits are widely consumed as juice (PJ). The potent antioxidant and anti-atherosclerotic activities of PJ are attributed to its polyphenols including punicalagin, the major fruit ellagitannin, and ellagic acid (EA). Punicalagin is the major antioxidant polyphenol ingredient in PJ. Punicalagin, EA, a standardized total pomegranate tannin (TPT) extract and PJ were evaluated for in vitro antiproliferative, apoptotic and antioxidant activities. Punicalagin, EA and TPT were evaluated for antiproliferative activity at 12.5-100 microg/ml on human oral (KB, CAL27), colon (HT-29, HCT116, SW480, SW620) and prostate (RWPE-1, 22Rv1) tumor cells. Punicalagin, EA and TPT were evaluated at 100 microg/ml concentrations for apoptotic effects and at 10 microg/ml concentrations for antioxidant properties. However, to evaluate the synergistic and/or additive contributions from other PJ phytochemicals, PJ was tested at concentrations normalized to deliver equivalent amounts of punicalagin (w/w). Apoptotic effects were evaluated against the HT-29 and HCT116 colon cancer cell lines. Antioxidant effects were evaluated using inhibition of lipid peroxidation and Trolox equivalent antioxidant capacity (TEAC) assays. Pomegranate juice showed greatest antiproliferative activity against all cell lines by inhibiting proliferation from 30% to 100%. At 100 microg/ml, PJ, EA, punicalagin and TPT induced apoptosis in HT-29 colon cells. However, in the HCT116 colon cells, EA, punicalagin and TPT but not PJ induced apoptosis. The trend in antioxidant activity was PJ>TPT>punicalagin>EA. The superior bioactivity of PJ compared to its purified polyphenols illustrated the multifactorial effects and chemical synergy of the action of multiple compounds compared to single purified active ingredients.

Sci Rep. 2016 Oct 7;6:34246. doi: 10.1038/srep34246.
Pomegranate extract decreases oxidative stress and alleviates mitochondrial impairment by activating AMPK-Nrf2 in hypothalamic paraventricular nucleus of spontaneously hypertensive rats.
Authors: Sun W1,2, Yan C3, Frost B4, Wang X5, Hou C3, Zeng M3, Gao H2, Kang Y2, Liu J3.


High blood pressure, or “hypertension,” is associated with high levels of oxidative stress in the paraventricular nucleus of the hypothalamus. While pomegranate extract is a known antioxidant that is thought to have antihypertensive effects, the mechanism whereby pomegranate extract lowers blood pressure and the tissue that mediates its antihypertensive effects are currently unknown. We have used a spontaneously hypertensive rat model to investigate the antihypertensive properties of pomegranate extract. We found that chronic treatment of hypertensive rats with pomegranate extract significantly reduced blood pressure and cardiac hypertrophy. Furthermore, pomegranate extract reduced oxidative stress, increased the antioxidant defense system, and decreased inflammation in the paraventricular nucleus of hypertensive rats. We determined that pomegranate extract reduced mitochondrial superoxide anion levels and increased mitochondrial function in the paraventricular nucleus of hypertensive rats by promoting mitochondrial biogenesis and improving mitochondrial dynamics and clearance. We went on to identify the AMPK-nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) pathway as a mechanism whereby pomegranate extract reduces oxidative stress in the paraventricular nucleus to relieve hypertension. Our findings demonstrate that pomegranate extract alleviates hypertension by reducing oxidative stress and improving mitochondrial function in the paraventricular nucleus, and reveal multiple novel targets for therapeutic treatment of hypertension.

Molecules 2017, 22(1), 177;
Pomegranate for Prevention and Treatment of Cancer: An Update
1 Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
2 Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA


Cancer is the second leading cause of death in the United States, and those who survive cancer may experience lasting difficulties, including treatment side effects, as well as physical, cognitive, and psychosocial struggles. Naturally-occurring agents from dietary fruits and vegetables have received considerable attention for the prevention and treatment of cancers. These natural agents are safe and cost efficient in contrast to expensive chemotherapeutic agents, which may induce significant side effects. The pomegranate (Punica granatum L.) fruit has been used for the prevention and treatment of a multitude of diseases and ailments for centuries in ancient cultures. Pomegranate exhibits strong antioxidant activity and is a rich source of anthocyanins, ellagitannins, and hydrolysable tannins. Studies have shown that the pomegranate fruit as well as its juice, extract, and oil exert anti-inflammatory, anti-proliferative, and anti-tumorigenic properties by modulating multiple signaling pathways, which suggest its use as a promising chemopreventive/chemotherapeutic agent. This review summarizes preclinical and clinical studies highlighting the role of pomegranate in prevention and treatment of skin, breast, prostate, lung, and colon cancers.


Pomegranates are an important fruit full of polyphenols, anthocyanins, antioxidants, and Nrf2 activators that help to make Ultimate Protector+ such an outstanding nutritional supplement.




Fred Liers PhD pH adjust hydrogen supplementsToday, I talk about hydrogen supplements with a twist. Specifically, I discovered that a unique combination of three products—MegahydrateActive H2 Ultra, and pH ADJUST Alkalinizing Formula—provides surprising benefits. I put this combination, or concoction, into water to produce a hydrogen-infused drink with potent antioxidant quenching capacity that also rapidly alkalinizes the body (increasing pH levels and buffering acids), and provides the important minerals potassium and magnesium.

Combining hydrogen supplements with pH ADJUST creates a hydrogen-infused drink giving you benefits from 1) Two types of hydrogen, hydride (H-) and molecular hydrogen (H2) with antioxidant and energizing properties, 2) Increased pH levels (greater alkalinity) to balance pH levels, 3) Bicarbonates helping buffer acids and replenish bicarbonate reserves in the body, and 4) Essential minerals (potassium, magnesium) in bio-available forms.

In practical terms, this drink is energizing, anti-aging (party due to free-radical quenching effects), hydrating, and powerfully alkaline-forming! What this means for you might be a revolutionary drink that by giving your body all the antioxidant benefits of hydrogen plus increasing your pH levels turns can significantly improve multiple aspects of health.

By buffering acidity and making you alkaline, this drink can improve things like the strength of bones and teeth (via buffering and remineralization), supports kidney health (as kidneys are responsible for your bicarbonate reserves), boosts oxygenation (and thereby supports easier breathing) because alkaline cells hold more oxygen, and stops or reduces acid indigestion, acid reflux, and other acid-related problems. That could be just the beginning of the benefits you might receive because increasing your pH levels and normalizing alkaline conditions (i.e., pH 7.35–7.45) positively impacts many systems in the body.


pH Adjust, Megahydrate, and Active H2 Ultra are good supplements when used by themselves. That is, they work well as stand alone supplements. But I have found the combination of all three offers maximum antioxidant, alkalization, buffering, and mineralization benefits.

pH Adjust maximizes the effects of hydrogen supplements by boosting alkalinity and buffering capacity through the inclusion of effective, natural forms of important minerals and bicarbonates, including: potassium bicarbonate, magnesium carbonate, potassium glycinate, and sodium bicarbonate.


There are potent synergistic effects to the combination of all three products. In particular, using both hydrogen negative ions (H-) or hydride and molecular hydrogen (H2) creates cascade effects in which hydrogen ions “recycle” themselves as antioxidants. The addition of pH Adjust brings its own set of benefits.

MEGAHYDRATE provides hydride or hydrogen negative ions (H-), also known as anions, that act significantly as antioxidants. These hydrogen ions can last up to three weeks in water. In the body, after the H- has donated its electron, it becomes simply “H” and proceeds to pair with another hydrogen atom to form H2 (molecular hydrogen), thereby continuing to exert free-radical quenching action. This is a major benefit of consuming H- in the quantities provided by Megahydrate.

ACTIVE H2 ULTRA provides molecular hydrogen (H2) directly into the body in significant amounts. Molecular hydrogen offers many benefits to the body, especially antioxidant benefits. Being an extremely small molecule, molecular hydrogen can enter into the smallest cellular compartments, including the nucleus of the cell, a place where most antioxidants are too large to enter) where it can exert its antioxidant capabilities. Molecular hydrogen actually provides a wide range of health benefits. (See the Molecular Hydrogen Institute (MHI) website for more information.)

pH ADJUST Alkalinizing Formula provides effective alkalinizing and buffering functions, as well as minerals (like potassium and magnesium) and bicarbonates needed for health. It is a fluffy, white powder that mixes easily in water, teas, coffee, and other liquids. It is formulated to rapidly increase pH levels, and acts as a buffering agent to balance pH in the body.

pH Adjust was created by my father, Dr. Hank Liers, HPDI’s founder and formulator of all “Dr. Liers Original” supplements. Dr. Hank been designing effective nutritional supplements since before 1988, the year he founded HPDI.

ph adjust hydrogen supplements active h2 ultra


Acid-base balance is critical in the body, where a pH level of 7.35–7.45 must be maintained. Modern diets and lifestyles tend to be acidifying for the body. Diets high in animal foods that are not adequately balanced with vegetable foods lead to acidity. Other factors include overconsumption of grains, alcohol, and other acid-forming foods. Stress can also play a role due too the acidifying effects of stress hormones like cortisol.

Moreover, the aging process itself depletes bicarbonate reserves. As noted, pH Adjust contains bicarbonates that help replenish bicarbonate reserves necessary for buffering acids. Finally, a significant portion of the population has low intake of potassium and magnesium, which pH Adjust includes as part of its design.

pH Adjust also includes sodium bicarbonate (baking soda), which is a well known acidity buffer and alkalinizer. For users, advantages of pH Adjust over pure sodium bicarbonate include reduced sodium intake, improved taste, and the provision of potassium and magnesium.


Potassium is critical in the body not only for alkalinity, but also for its role in the sodium-potassium pump which is important in the production of cellular energy (ATP) and for preventing too high levels of sodium from entering cells.

Magnesium is essential in the body and plays a role in wide range of functions, including cellular energy production, immune function, muscle and connective tissue health, and more than 400 enzyme reactions.

pH ADJUST is a highly effective buffering formula, which tends to bring pH levels (low or high) back into the optimal range (7.35-7.45). This buffering capacity means users can both avoid acidosis (high acidity) and alkalosis (high alkalinity).



Start with 8–16 ounces of fresh, purified water. Add 1–2 scoops of pH ADJUST, 1–2 capsules (or 1-2 scoops) of MEGAHYDRATE, and 1–2 ACTIVE H2 ULTRA tablets. Add the Active H2 Ultra tablets last, and let them effervesce completely (about 1 minute) before drinking.

This alkaline-forming, hydrogen-infused water is best taken on an empty stomach. It is ideal to drink in the morning or the afternoon (away from food). Allow at least 15–30 minutes before eating, or see what works for you. I sometimes eat light foods 10 minutes after taking this drink.

I recommend testing your pH levels (salivary and/or urinary) using pH test paper (litmus paper). pH test paper gives you a way to accurately track your pH levels. You can also use it to measure the pH of foods you consume, such as hydrogen-infused water and drinks containing pH Adjust.

Note: Many HPDI customers use pH Adjust in other drinks, including tea, coffee, and ketogenic coffee. Coffee can be acidic and acid-forming beverage, so adding pH Adjust helps buffer the acidity. Many users say pH Adjust tastes mild or good in coffee, and some say it adds a certain creaminess to it.


The only way you will know how beneficial hydrogen-infused water with pH Adjust can be—or how well it works for you—is to make it and use it! You will likely find yourself surprised by how energizing, alkalinizing, and mineralizing it truly is for you. And how good you feel when you drink it!

Consider testing the pH of your water first using pH test paper. Many people drink highly acidic water (pH 6 or less) without realizing it. Just because your water is filtered or purified does not necessarily mean it is alkaline. pH Adjust can “fix” this problem. Other people report that their water is highly alkaline (8.0+). Either way, pH Adjust can buffer the water to put it into the range slightly alkaline range of about 7.35–7.45. If you have extremely acidic water, you might need to use two servings of pH Adjust in 8–16 ounces of water. Play with it.

Let us know how this works out for you. We welcome your feedback and success stories!


Hydrogen supplements and pH Adjust are made for each other, and create wonderfully alkalinizing hydrogen-infused water. But there are other ways to use pH Adjust. As I mentioned, you might like to read about making pH Adjust Coffee or Ketogenic Coffee using pH Adjust. Or watch my videos below. Also, did you know you can use pH Adjust in lemonade and other juices?


pH ADJUST COFFEE: https://youtu.be/72fAz9ob3bo
“How to use pH Adjust Alkalinizing Formula in Coffee”

KETOGENIC COFFEE VIDEO: https://youtu.be/yzyVbFD_JVA
“How to Make Keto Coffee with pH Adjust – Alkalinizing Coffee”





pH Adjust, Megahydrate, and Active H2 Ultra are available from Health Products Distributors, Inc. (HPDI):

pH ADJUST: http://www.integratedhealth.com/ph-adjust.html

MEGAHYDRATE: http://www.integratedhealth.com/megahydrate-60-caps.html

ACTIVE H2 ULTRA: http://www.integratedhealth.com/hydrogen-tablets.html

PH TEST PAPER (Hydrion brand): http://www.integratedhealth.com/ph-paper.html


HPDI WEBSITE: http://www.IntegratedHealth.com
RESELLER SITE: http://www.HealthProductsDistributors.com

HPDI BLOG: http://www.integratedhealthblog.com
RESELLER BLOG: http://www.healthproductsdistributors.com/blog (a blog just for HPDI resellers)

HPDI NEWSLETTER: http://www.integratedhealth.com/newsletter.html

HPDI OFFICE (Oracle, AZ): 1-800-228-4265 (M-F 8–3:45 pm Arizona Time)

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