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PREVENTING FREE RADICAL DAMAGE WITH ULTIMATE PROTECTOR+

Back in 2012, I learned about Nrf2 activators and was excited about pursuing the development of a supplement that would incorporate the new knowledge we were learning into a effective product for preventing free radical damage. At that time, I published two articles: New Directions for Preventing Free Fadical Damage and Natural Phytochemical Nrf2 Activators for Chemoprevention. I started working on a new Nrf2-activator formula I called Ultimate Protector that incorporated many of the ideas contained in these articles. The product was introduced November 2012.

More recently, in early 2019, I decided to upgrade the product using new information and ingredients. The upgraded product is called Ultimate Protector+. In this article, I provide new details of our design logic and product ingredients. I expect the new formula to be released in July 2019.

Ultimate Protector+

Ultimate Protector+ is new and improved!

PREVENTING FREE RADICAL DAMAGE WITH ULTIMATE PROTECTOR+

Ultimate Protector+™ is a unique cell protection formula that simultaneously meets the needs for high levels of non-GMO Vitamin C, full spectrum antioxidants (high ORAC values), and protective enzyme activators (Nrf2 activators) in a single product. This potent combination of characteristics distinguishes the formula because no other single product available today offers such complete protection. This is the single best formula for preventing free radical damage that is available.

Ultimate Protector+™ provides extremely high levels of natural antioxidants, including high levels of ingredients such as polyphenols, flavonoids, anthocyanidins, oligomeric proanthocyanidins, catechins, curcuminoids, pterostilbene, resveratrol, chlorogenic acid, punicalagins, zeaxanthin and other carotenoids that act powerfully as antioxidants. These antioxidants come from more than 12 plant-based ingredients with demonstrated free-radical quenching capacity. These “exogenous” food-based antioxidants (supplied from outside the body) provide you with immense oxidative defenses that can be used to defend against free-radical assault.

Ultimate Protector+™ contains USP-grade non-GMO Vitamin C , SFB® standardized fruit blend (~50% polyphenols, high-ORAC powder: 9,000 µmole TE/g) from Grape, Cranberry, Pomegranate, Blueberry, Apple, Mangosteen, Bilberry, Chokeberry, and Goji Berry), Curcumin (standardized extract with 95% curcuminoids), Trans-Resveratrol (98% from Giant Knotweed), Green Tea Extract (90% polyphenols, 50% EGCG), VinCare® Whole Grape Extract (>80% polyphenols, ORAC>19,000 µmole TE/g), Calcium Malate, Magnesium Malate, and Bioperine® (a patented black pepper extract that enhances absorption of all ingredients and is a known Nrf2 activator).

Ultimate Protector+™ is contained in a capsule suitable for vegetarians (i.e., a veggie cap) and contains no magnesium stearate.

NUTRITIONAL CONSIDERATIONS AND APPLICATIONS

Ultimate Protector+™ satisfies three distinct needs:

1) The need for a non-GMO Vitamin C product. That is, a Vitamin C formula that avoids protein from genetically modified sources such as corn, potatoes, or beets.

2) The need for a single, powerful antioxidant formula for preventing free radical damage. That is, a single, easy-to-take antioxidant formula offering a broad range of extremely high-ORAC plant source antioxidants. These antioxidants should protect against the full range of free radicals found in the human body including: superoxide anion (O2·-), peroxyl radicals (ROO·), hydroxyl radicals (HO·), singlet oxygen (1O2), and peroxynitrite (ONOO-).

3) The need for a supplement providing a full spectrum of Nrf2 activators. That is, a supplement providing a wide range of natural Nrf2 transcription factor activators that allow the body to make its own antioxidant enzymes (e.g., superoxide dismutase (SOD), catalase, hemeoxygenase, and glutathione peroxidase). Scientific research has shown that these are found naturally in many fruits, vegetable, and herbs. These ingredients provide a wide range of Nrf2 activators that result in significantly high levels of the endogenously produced antioxidant enzymes.

The ways Ultimate Protector+™ satisfies these three needs are discussed below:

1) NON-GMO VITAMIN C / ASCORBIC ACID

High-quality, USP grade Vitamin C has been obtained historically from corn, potatoes, and/or beets. Unfortunately, many of these sources have to a large extent gone to genetically modified (GMO) variants. However, with highly refined production methods and the use of PCR testing, we have been able to obtain final products that are free from GMOs.

In nature, Vitamin C is found generally in plant sources containing polyphenols. Vitamin C and polyphenols work together to provide a high level of antioxidant protection and they support the function of each other in the process. For example, Vitamin C is needed by the body to produce collagen and certain polyphenols (especially oligomeric proanthocyanidins) (OPCs) crosslink the collagen and make it stronger.

2) EXTREMELY HIGH ORAC SOURCES

Free radicals are reactive species that can have adverse effects on normal physiological functions. Studies associate the five major types of free radicals (i.e., hydroxyl, peroxyl, peroxynitrite, singlet oxygen, and superoxide anion) with health conditions such as cardiovascular disease, hypertension, breakdown of vital proteins, chronic inflammation, Alzheimer’s disease, and certain cancers. Avoiding free radical damage is the goal.

Antioxidants function as a vital line of defense against free radicals by blocking their attack on DNA, vital proteins, lipids, and amino acids. Until now, efforts to identify the effect of antioxidants on all five types of free radicals were constrained by limited testing procedures. However, new technological developments have resulted in a comprehensive testing method called the Total ORAC5.0™ assay. Because of the development of the Total ORAC5.0™ test, it is now possible to target and measure the effects of antioxidants on the five major types of free radicals found in the body.

We are currently in the process of testing Ultimate Protector+™ using this new ORAC5.0™ assay. We are confident that our formula offers protection against these five major types of free-radicals because we combine a wide range of extremely high-ORAC fruit, vegetable, and herbal blends. As soon as the results are available (in July 2019), we will update this article with the findings.

3) NRF2 TRANSCRIPTION FACTOR ACTIVATORS

In order to survive under a variety of environmental or intracellular stresses, our cells have developed highly efficient protective mechanisms to protect themselves from oxidative or electrophilic challenges. Proteins that comprise phase II detoxification and antioxidant enzymes provide an enzymatic line of defense against reactive oxygen species (ROS). These enzymes include superoxide dismutase (SOD), catalase, glutathione peroxidase, glutathione S-transferase (GST), and glutamate cysteine ligase.

Induction of phase II and antioxidant enzymes are regulated at the DNA/gene level by an antioxidant responsive element (ARE). ARE-mediated gene expression plays a central role in the cellular defense against cellular oxidative damage. Experimental evidence supports the view that induction of ARE-mediated cytoprotective enzymes is a critical and sufficient mechanism to enable protection against disease provoked by environmental and endogenous insults.

One of the key ARE-binding transcription factors is Nrf2. Induction of cytoprotective enzymes in response to ROS, electrophiles, and phytochemicals is a cellular event that is highly dependent on Nrf2 protein. By activating Nrf2 signaling, phytochemicals can increase cellular detoxification and antioxidant enzymes, thereby enhancing removal of ROS and toxic chemicals and preventing disease. Numerous research studies carried out over the last 15 years have demonstrated the effectiveness of a very wide range of Nrf2 activators extracted from fruits, vegetables, and herbs.

For example, a study with sulforaphane (an isothiocyanate present abundantly in cruciferous vegetables) shows that oral administration of this phytochemical can effectively block benzo[a]pyrene-induced forestomach tumors in mice. This protective effect was abrogated in mice that could not produce Nrf2. This supports the critical role of phase II detoxification and antioxidant enzymes in the prevention of carcinogenesis by chemopreventive agents.

Nrf2 is normally bound in the cytoplasm of cells to a protein called KEAP1. However, when an appropriate phytochemical agent attaches to a kinase receptor on the cell wall a phosphate group is released that causes the Nrf2 to be released. Also, there are other mechanisms that allow Nrf2 to be released from KEAP1. The released Nrf2 then migrates into the cell nucleus and causes an antioxidant enzyme (e.g., superoxide dismutase (SOD)) to be fabricated and released. This endogenously produced enzyme then can protect against ROS, electrophiles, and other toxic agents.

In practical experience, it has been found that a combination of multiple polyphenols works significantly better than single ingredients. In fact, in one experiment it was found that a combination of five ingredients all known to be Nrf2 activators was 18 times more effective than any single ingredient. Furthermore, it was found that this combination of five ingredients was able to increase levels of SOD by 30% and catalase by 56% after 120 days of taking the combination.

In view of the considerations above, we include a wide range of Nrf2 activators in Ultimate Protector+™. These include a large variety of freeze-dried and concentrated fruits, vegetables, and herbs. These include Grape, Cranberry, Pomegranate, Blueberry, Apple, Mangosteen, Bilberry, Chokeberry, Goji Berry), Curcumin (standardized extract with 95% curcuminoids), Trans-Resveratrol (98% from Giant Knotweed), Green Tea Extract (93% polyphenols, 50% EGCG), VinCare® Whole Grape Extract (>80% polyphenols, ORAC>19,000 µmole TE/g)

Ultimate Protector+™ includes the following phytonutrients in its array of freeze-dried and concentrated fruits, vegetables, and herbs: polyphenols, flavonoids, anthocyanins, catechins, proanthocyanins, ellagic acid, xanthines, chlorogenic acid, pterostilbenes, resveratrol, phloridzin, quercetin, zeaxanthin, carotinoids, polysaccharides, quinic acid, and more.

The phytochemical ingredients in Ultimate Protector+™ are discussed below:

1. SFB® – (Standardized Fruit Blend)

SFB® is a nutritious, non-GMO blend that provides a broad spectrum of polyphenols, anthocyanins, and other antioxidants derived from water and/or ethanol extracts of grape (Vitis vinifera), cranberry (Vaccinium macrocarpon), pomegranate (Punica granatum) with >75% polyphenols, blueberry (Vaccinium uliginosum), apple (Malus pumilla Mill), mangosteen (Garcinia mangostana), bilberry (Vaccinium myrtillis), chokeberry (Aronia arbutifolia), and goji berry (Lycium barbarum). This powder has an ORAC value in excess of 9,000 µmole TE/g and contains 50% polyphenols.

Polyphenols and anthocyanins are not all created equal. Every fruit, vegetable and herb provides its own set of unique polyphenols and anthocyanins that reside in the body for different lengths of time and in different locations, providing a range of benefits. SFB® has been designed to provide a wide range of plant polyphenols, flavonoids, anthocyanins, catechins, OPCs, zeaxanthin and other carotinoids, etc. Published research associates these plant ingredients with healthy aging, inflammation management, improved blood sugar metabolism, and cardiovascular disease management.

SFB® provides the following benefits: Superior source of natural antioxidants and Nrf2 activators, helps ameliorate the effects of premature aging, promotes cardiovascular health, promotes healthy brain function and mental acuity, promotes healthy vision, promotes healthy blood sugar levels, and is an excellent source of flavonoids and organic acids.

I have prepared detailed blog articles for the ingredients in SFB®. Below some of these are summarized and links to the articles are provided.

a) Cranberry Extract

Ultimate Protector+ Includes Cranberry

Ultimate Protector+ Includes Cranberry Extract

Cranberry extract is an especially good source of antioxidant polyphenols. In animal studies, the polyphenols in cranberries have been found to decrease levels of total cholesterol and so-called “bad” cholesterol. Cranberries may also inhibit the growth of tumors in human breast tissue and lower the risk of both stomach ulcers and gum disease.

Here is a list of the antioxidant and anti-inflammatory phytonutrients in found in cranberry extract.

Type of Phytonutrient Specific Molecules
Phenolic Acids hydroxybenzoic acids including vanillic acids;
—Phenolic Acids (cont.) hydroxycinnamic acids inculding caffeic,
—Phenolic Acids (cont.) coumaric, cinnamic, and ferulic acid
Proanthocyanidins epicatechin oligomers
Anthocyanins cyanidins, malvidins, and peonidins
Flavonoids quercetin, myricetin, kaempferol
Triterpenoids ursolic acid

OTHER CRANBERRY INFORMATION

    • Cranberries hold significantly high amounts of phenolic flavonoid phytochemicals called oligomeric proanthocyanidins (OPC’s). Scientific studies have shown that consumption of the berries have potential health benefits regarding cancer, aging and neurological diseases, inflammation, diabetes, and bacterial infections.
    • Antioxidant compounds in cranberry extract including OPC’s, anthocyanidin flavonoids, cyanidin, peonidin and quercetin may support cardiovascular health by counteracting against cholesterol plaque formation in the heart and blood vessels. Further, these compounds help the human body lower LDL cholesterol levels and increase HDL-good cholesterol levels in the blood.
    • Scientific studies show that cranberry juice consumption offers protection against gram-negative bacterial infections such as E.coli in the urinary system by inhibiting bacterial-attachment to the bladder and urethra.
    • It is known that cranberries turns urine acidic. This, together with the inhibition of bacterial adhesion helps prevent the formation of alkaline (calcium ammonium phosphate) stones in the urinary tract by working against proteus bacterial-infections.
    • In addition, the berries prevent plaque formation on the tooth enamel by interfering with the ability of the gram-negative bacterium, Streptococcus mutans, to stick to the surface. In this way cranberries helps prevent the development of cavities.
    • The berries are also good source of many vitamins like vitamin C, vitamin A, ß-carotene, lutein, zea-xanthin, and folate and minerals like potassium, and manganese.
  • Oxygen Radical Absorbance Capacity (ORAC) demonstrates cranberry at an ORAC score of 9584 µmol TE units per 100 g, one of the highest in the category of edible berries.

b) Pomegranate Extract

Ultimate Protector+ Includes Pomegranate

Ultimate Protector+ Includes Pomegranate

For thousands of years, the pomegranate has been extensively used as a source of food and medicine. Full of antioxidants, vitamin C and potassium, pomegranate has been used to control body weight, reduce cholesterol, fight against cell damage, and inhibit viral infections. Pomegranate extracts have anti-bacterial effects.

Pomegranates are rich in ellagic acid, gallic acid, lignans, polyphenols and other bioactive compounds, and have been shown to lower blood pressure and enhance vascular function. Furthermore, it can offset some of the negative effects of medications and chemicals. These compounds occur naturally in its peel, seeds, leaf and juice. The seeds are high in p-coumaric acid, plant sterols, tannins and fatty acids. In addition to their antihypertensive effects, they may help reduce blood sugar levels.

Pomegranate fruit is a rounded berry with a thick reddish skin covering approximately 200–1400 white to deep red or purple seeds. Pomegranate seeds are edible and hold strong antioxidant and anti-inflammatory properties due to their high content of hydrolysable tannins and anthocyanins. As compared to the antioxidant activity of vitamin E, β-carotene, and ascorbic acid, the pomegranate antioxidants appear unique due to combinations of a wide array of polyphenols, having a broader range of action against several types of free radicals. As compared to the recognized antioxidants in red wine and green tea, anthocyanins from pomegranate fruit possess significantly higher antioxidant activity.

Pomegranate has been used in various medicinal systems of medicine for the treatment and therapy of a multitude of diseases and ailments. In the ancient Indian medicinal system, i.e., in Ayurvedic medicine, the pomegranate was considered to be a whole pharmacy unto itself. It was recommended to be used as an antiparasitic agent and to treat diarrhea and ulcers. The medicinal properties of pomegranate have sparked significant interest in today’s scientific community as evidenced by the scientific research relating to health benefits of pomegranate that have been published in last few decades.

Studies have shown that pomegranate and its constituents can efficiently affect multiple signaling pathways involved in inflammation, cellular transformation, hyperproliferation, angiogenesis, initiation of tumorigenesis, and eventually suppressing the final steps of tumorigenesis and metastasis. The pomegranate constituents are shown to modulate transcription factors, pro-apoptotic proteins, anti-apoptotic proteins, cell cycle regulator molecules, protein kinases, cell adhesion molecules, pro-inflammatory mediators, and growth factors.

c) Chokeberry (Aronia)

Ultimate Protector+ Includes Chokeberry

Ultimate Protector+ Includes Chokeberry

HEALTH BENEFITS OF CHOKEBERRY (ARONIA)

Aronia melanocarpa (black chokeberry) has attracted scientific interest due to its deep purple, almost black pigmentation that arises from dense contents of polyphenols, especially anthocyanins. Total polyphenol content is 1752 mg per 100 g in fresh berries, anthocyanin content is 1480 mg per 100 g, and proanthocyanidin concentration is 664 mg per 100 g. These values are among the highest measured in plants to date.

The plant produces these pigments mainly in the leaves and skin of the berries to protect the pulp and seeds from constant exposure to ultraviolet radiation and production of free radicals. By absorbing UV rays in the blue-purple spectrum, leaf and skin pigments filter intense sunlight, serve antioxidant functions and thereby have a role assuring regeneration of the species.

Analysis of polyphenols in chokeberries has identified the following individual chemicals (among hundreds known to exist in the plant kingdom): cyanidin-3-galactoside, cyanidin-3-arabinoside, quercetin-3-glycoside, epicatechin, caffeic acid, delphinidin, petunidin, pelargonidin, peonidin, and malvidin.All these except caffeic acid are members of the flavonoid category of phenolics.

In a standard measurement of antioxidant strength, the oxygen radical absorbance capacity or ORAC, demonstrates aronia to have one of the highest values yet recorded for a fruit — 16,062 micro moles of Trolox Eq. per 100 g. The components contributing to this high measurement were both anthocyanins and proanthocyanidins, with the proanthocyanidin level “among the highest in foods”, which may explain their potent astringent taste.

d) Goji Berry

Ultimate Protector+ Includes Goji Berry

Ultimate Protector+ Includes Goji Berry

Goji Berries contain abundant polysaccharides (LBPs, comprising 5%–8% of the dried fruits), scopoletin (6-methoxy-7-hydroxycoumarin, also named chrysatropic acid, ecopoletin, gelseminic acid, and scopoletol), the glucosylated precursor, and stable vitamin C analog 2-O-β-D-glucopyranosyl-L-ascorbic acid, carotenoids (zeaxanthin and β-carotene), betaine, cerebroside, β-sitosterol, flavonoids, amino acids, minerals, and vitamins (in particular, riboflavin, thiamin, and ascorbic acid).

The predominant carotenoid is zeaxanthin, which exists mainly as dipalmitate (also called physalien or physalin). The content of vitamin C (up to 42 mg/100 g) in goji berry (also known as wolfberry) is comparable to that of fresh lemon fruits. As to the seeds, they contain zeaxanthin (83%), β-cryptoxanthin (7%), β-carotene (0.9%), and mutatoxanthin (1.4%), as well as some minor carotenoids.

In fact, increasing lines of experimental studies have revealed that L. barbarum berries have a wide array of pharmacological activities, which is thought to be mainly due to its high LBPs content. Water-soluble LBPs are obtained using an extraction process that removes the lipid soluble components such as zeaxanthin and other carotenoids with alcohol. LBPs are estimated to comprise 5%–8% of LBFs and have a molecular weight ranging from 24 kDa to 241 kDa. LBPs consist of a complex mixture of highly branched and only partly characterized polysaccharides and proteoglycans.

The glycosidic part accounts, in most cases, for about 90%–95% of the mass and consists of arabinose, glucose, galactose, mannose, rhamnose, xylose, and galacturonic acid. LBPs are considered the most important functional constituents in LBFs. Different fractions of LBPs have different activities and the galacturonic acid content is an imperative factor for activities of LBP. The bioactivities of polysaccharides are often in reverse proportion with their molecular weights. Increasing lines of evidence from both preclinical and clinical studies support the medicinal, therapeutic, and health-promoting effects of LBPs.

e) Mangosteen

Ultimate Protector+ Includes Mangosteen

Ultimate Protector+ Includes Mangosteen

The Mangosteen extract in Ultimate Protector+ has been extracted with non-GMO food grade ethanol and distilled water. Testing has indicated the product contains over 10% polyphenols.

Mangosteen extract in obtained from the skin and whole fruit for which numerous biological activities have been reported including: antimutagenic, antibacterial, hypocholesterolemic, antioxidant, and protective against tumorigenesis.

Mangosteen contains nutrients with antioxidant capacity, such as vitamin C and folate. Plus, it provides xanthones — a unique type of plant compound known to have strong antioxidant properties. In several test-tube and animal studies, the antioxidant activity of xanthones has resulted in anti-inflammatory, anticancer, anti-aging, heart protective, and antidiabetic effects.

Additionally, some research suggests that certain plant compounds in mangosteen may have antibacterial properties — which could benefit your immune health by combating potentially harmful bacteria. In a 30-day study in 59 people, those taking a mangosteen-containing supplement experienced reduced markers of inflammation and significantly greater increases in healthy immune cell numbers compared to those taking a placebo.

f) Apple Extract

Ultimate Protector+ Includes Apple

Apples contain a large concentration of flavonoids, as well as a variety of other phytochemicals, and the concentration of these phytochemicals may depend on many factors, such as cultivar of the apple, harvest and storage of the apples, and processing of the apples. The concentration of phytochemicals also varies greatly between the apple peels and the apple flesh.

Some of the most well studied antioxidant compounds in apples include quercetin-3-galactoside, quercetin-3-glucoside, quercetin-3-rhamnoside, catechin, epicatechin, procyanidin, cyanidin-3-galactoside, coumaric acid, chlorogenic acid, gallic acid, and phloridzin. Recently researchers have examined the average concentrations of the major phenolic compounds in six cultivars of apples. They found that the average phenolic concentrations among the six cultivars were: quercetin glycosides, 13.2 mg/100 g fruit; vitamin C, 12.8 mg/100 g fruit; procyanidin B, 9.35 mg/100 g fruit; chlorogenic acid, 9.02 mg/100 g fruit; epicatechin, 8.65 mg/100 g fruit; and phloretin glycosides, 5.59 mg/100 g fruit.

The compounds most commonly found in apple peels consist of the procyanidins, catechin, epicatechin, chlorogenic acid, phloridzin, and the quercetin conjugates. In the apple flesh, there is some catechin, procyanidin, epicatechin, and phloridzin, but these compounds are found in much lower concentrations than in the peels. Quercetin conjugates are found exclusively in the peel of the apples. Chlorogenic acid tends to be higher in the flesh than in the peel.

Because the apple peels contain more antioxidant compounds, especially quercetin, apple peels may have higher antioxidant activity and higher bioactivity than the apple flesh. Research showed that apples without the peels had less antioxidant activity than apples with the peels. Apples with the peels were also better able to inhibit cancer cell proliferation when compared to apples without the peels. More recent work has shown that apple peels contain anywhere from two to six times (depending on the variety) more phenolic compounds than in the flesh, and two to three times more flavonoids in the peels when compared to the flesh. The antioxidant activity of these peels was also much greater, ranging from two to six times greater in the peels when compared to the flesh, depending on the variety of the apple. This work is supported a study which found that rats consuming apple peels showed greater inhibition of lipid peroxidation and greater plasma antioxidant capacity when compared to rats fed apple flesh.

Many of these phytochemicals from apples have been widely studied, and many potential health benefits have been attributed to these specific phytochemicals. The procyanidins, epicatechin and catechin, have strong antioxidant activity and have been found to inhibit low density lipoprotein (LDL) oxidation in vitro. In mice, catechin inhibits intestinal tumor formation and delays tumors onset. One study found that chlorogenic acid has very high alkyl peroxyl radical (ROO•) scavenging activity. Compared to about 18 other antioxidant compounds (including quercetin, gallic acid, α-tocopherol), chlorogenic was second only to rutin. Since ROO• may enhance tumor promotion and carcinogenesis, chlorogenic acid may add to the protective effect of apples against cancer. Chlorogenic acid has been found to inhibit 8-dehydroxy-deoxyguanosine formation in cellular DNA in a rat model following treatment with 4-nitroquinoline-1-oxide.

Quercetin is also a strong antioxidant, and is thought to have potential protective effects against both cancer and heart disease. Briefly, quercetin has been found to down regulate expression of mutant p53 in breast cancer cells, arrest human leukemic T-cells in G1, inhibit tyrosine kinase, and inhibit heat shock proteins. Quercetin has protected Caco-2 cells from lipid peroxidation induced by hydrogen peroxide and Fe2+. In mice liver treated with ethanol, quercetin decreased lipid oxidation and increased glutathione, protecting the liver from oxidative damage. Recently, it has been found that high doses of quercetin inhibit cell proliferation in colon carcinoma cell lines and in mammary adenocarcinoma cell lines, but at low doses quercetin increased cell proliferation (20% in colon cancer cells and 100% in breast cancer cells). However, low doses of quercetin (10 uM) inhibited cell proliferation in Mol-4 Human Leukemia cells and also induced apoptosis. Quercetin inhibited intestinal tumor growth in mice, but not in rats. Low levels of quercetin inhibited platelet aggregation, calcium mobilization, and tyrosine protein phosphorylation in platelets. Modulation of platelet activity may help prevent cardiovascular disease.

g) Blueberry and Bilberry Extract

wild bilberry and wild blueberry
Wild bilberry and wild blueberry provide Nrf2 activators.

The key compounds in bilberry fruit are called anthocyanins and anthocyanosides. These compounds help build strong blood vessels and improve circulation to all areas of the body. They also prevent blood platelets from clumping together (helping to reduce the risk of blood clots), and they have antioxidant properties (preventing or reducing damage to cells from free radicals). Anthocyanins boost the production of rhodopsin, a pigment that improves night vision and helps the eye adapt to light changes.

Bilberry fruit is also rich in tannins, a substance that acts as an astringent. The tannins have anti-inflammatory properties and may help control diarrhea.

Bilberries have been shown to have the highest Oxygen Radical Absorbance Capacity (ORAC) rating of more than 20 fresh fruits and berries. The antioxidant properties of bilberries were shown to be even stronger than those of cranberries, raspberries, strawberries, plums, or cultivated blueberries.

The antioxidant powers and health benefits of bilberries and blueberries can be attributed to a number of remarkable compounds contained in them, including the following:

  • Anthocyanins
    • malvidins
    • delphinidins
    • pelargonidins
    • cyanidins
    • peonidins
  • Hydroxycinnamic acids
    • caffeic acids
    • ferulic acids
    • coumaric acids
  • Hydroxybenzoic acids
    • gallic acids
    • procatchuic acids
  • Flavonols
    • kaempferol
    • quercetin
    • myricetin
  • Other phenol-related phytonutrients
    • pterostilbene
    • resveratrol
  • Other nutrients
    • lutein
    • zeaxanthin
    • Vitamin K
    • Vitamin C
    • manganese

2) Curcumin

Ultimate Protector+ Includes Curcumin

Ultimate Protector+ Includes Curcumin

We have included Curcumin (95% curcuminoids in ULTIMATE PROTECTOR™. This ingredient contains three main chemical compounds – Curcumin, Demethoxycurcumin and Bisdemethoxycurcumin – collectively known as Curcuminoids and all derived from Turmeric. Curcumin has been shown to be one of the most potent Nrf2 transcription factor activators. Studies have reported that curcumin and turmeric protect the liver against several toxicants both in vitro and in vivo. A number of reports showed the curative action of turmeric and curcuminoids. Curcumin is a potent scavenger of free radicals such as superoxide anion radicals, hydroxyl radicals, and nitrogen dioxide radicals. It exerts powerful antioxidant and anti-inflammatory properties.


3) Trans-Resveratrol (98% from Polygonum cuspidatum – giant knotweed)

giant knotweed resveratrol

Knotweed (Polygonum cuspidatum) is a major source for resveratrol.

Trans-resveratrol provides antioxidant protection, boosts cellular energy, and balances the immune system. It has been proven in studies to activate the SIRT1 longevity gene and enhance cellular productivity. Several research studies have shown that trans-resveratrol activates Nrf2 transcription factor, significantly modulates biomarkers of bone metabolism, inhibits pro-inflammatory enzymes such as COX-1 and COX-2, and exhibits cardioprotective effects, neuroprotective properties, and caloric restrictive behavior. Trans-resveratrol has shown the ability to increase the number of mitochondria thereby increasing total daily energy. Studies have shown that trans-resveratrol promotes an increase in mitochondrial function. Increased mitochondrial function translates into an increase in energy availability, improved aerobic capacity, and enhanced sensorimotor function. Trans-resveratrol has an ORAC value of 31,000 µmole TE/g.


4) Green Tea Extract

Ultimate Protector+ Includes Green Tea Extract

Ultimate Protector+ Includes Green Tea Extract

Green Tea Extract contains highly bioavailable bioflavonoid complexes that in research studies have been shown to have powerful antioxidant capability. Green tea extract is obtained from the unfermented leaves of Camellia sinensis for which numerous biological activities have been reported including: cell protective, antimicrobial, and antioxidant. The green tea extract in Ultimate Protector is extracted is extracted by non-GMO ethanol and distilled water and contains ~ 90% polyphenols and 50% epigallocatechingallate (EGCG).

Epigallocatechin gallate (EGCG) is the most abundant catechin compound in green tea. It is well established that EGCG is a potent antioxidant and anti-inflammatory agent. Epidemiological studies show that consumption of 100 or more mg of EGCG per day is beneficial, as it is the most potent Nrf2 activator among all green tea catechins. EGCG exhibits robust diffusion through bodily tissues, including the endothelium of the blood brain barrier.

EGCG has the capacity to activate Nrf2/ARE and induce Heme oxygenase-1 (HO-1) expression. Several studies have shown that EGCG can also interact with kinases, causing the disassociation of Nrf2/Keap1 complex.

Protective effects of EGCG have been reported against ischemia/reperfusion injury. Administration of EGCG showed improved neurologic scores, reduced infarct volume, and ameliorated neuronal apoptosis due to increased GSH biosynthesis (via Nrf2 activation) and decreased ROS content. By inducing the expression of Nrf2 and HO-1, EGCG increases important endogenous antioxidants in microglial cells.

5) VinCare® whole grape extract (seed, pulp, and skin)

Ultimate Protector+ Includes Whole Grape Extract

Ultimate Protector+ Includes Whole Grape Extract

Whole Grape Extract contains highly bioavailable bioflavonoid complexes that in research studies have been shown to have powerful antioxidant capability. The Oligomeric Proanthocyanidins (OPCs) in grape extract are able to strengthen collagen fibers in aging or damaged connective tissue and can act as a preventative against connective tissue degradation. Some research indicates that anthocyanidins, which are found in extracts of grape seed, skin, and stems (but not in grape seed extract), can reduce oxidized glutathione while at the same time become reduced themselves. In addition, extracts of grape skin and pulp (but not those of grape seed extract) contain trans-resveratrol that has been shown to have cell protective effects.

Grape seed extract has been reported to demonstrate a remarkable spectrum of biological, pharmacological and therapeutic properties against oxidative stress. The antioxidative activities of grape seed extract have been found to be much stronger than those of vitamins C and E. Studies have indicated that grape seed extract showed a protective effect on cardiovascular disease, nephropathy, atherosclerosis, and neuropathy, among other conditions.

Vincare® contains ~80% polypnenols and has an ORAC value of about 19,000 µmole TE/g. ORAC 5.0 testing of grape seed extract exhibits one of the highest values of any tested material at about 100,000 µmole TE/g.

It has been shown that grape seed OPCs activate nuclear erythroid2-related factor2 (Nrf2), which is a key antioxidative transcription factor, with the concomitant elevation of downstream hemeoxygenase-1 (HO-1). Click here to view an excellent article entitled Proanthocyanidins [OPCs] against Oxidative Stress: From Molecular Mechanisms to Clinical Applications.

7) Bioperine®:

Bioperine® is a black pepper extract that has been shown to enhance the absorption of nutrients by 30–60 percent and makes all of the nutrients in this product more effective.

Ultimate Protector+™ will be most effective when used in conjunction with other foundational nutritional supplements that support the body’s metabolism, including Multi Two or Mighty Multi-Vite!™ (therapeutic multivitamin formulas), Omega Plus (essential fatty acids with Vitamin E), PRO-C™ (antioxidant formula), and one of our high-RNA Rejuvenate!™ superfoods.

COMPOSITION: six veggie capsules provides the following percentages of the Daily Value:

Serving Size: 6 Veggie Capsules Servings per Container: 30
Amount Per Serving Amounts % Daily Value
Vitamin C (as 100% USP-grade, non-GMO ascorbic acid) 1,500 mg 1667%
Calcium (from calcium malate) 60 mg 6
Magnesium (from magnesium malate) 60 mg 15
SFB®† (50% polyphenols, Orac: 9,000 units/gm) 180 mg *
Curcumin (95% min. curcuminoids from Curcuma longa) (root) 135 mg *
Green Tea extract (92% polyphenols, 50% EGCG) 135 mg *
Trans-Resveratrol 98% 135 mg *
Vincare®† whole grape extract (80% polyphenols, Orac: 19,000 units/gm) 135 mg *
Bioperine®†† 7.5 mg *
*
* Daily Value not established

Other ingredients: vegetarian capsule (veggie cap), microcrystalline cellulose, silica, and ascorbyl palmitate.

Directions for Use: As a dietary supplement take two capsules three times daily with food, or as directed by a health care professional.

ULTIMATE PROTECTOR Does Not Contain: wheat, rye, oats, barley, corn, gluten, soy, egg, dairy, yeast, sugar, shellfish, GMOs, wax, preservatives, colorings, or artificial flavorings.

ULTIMATE PROTECTOR+™ will be most effective when used in conjunction with other foundational nutritional supplements that support the body’s metabolism, including Multi Two or Mighty Multi-Vite!™ (therapeutic multivitamin formulas), Essential Fats plus E (essential fatty acids with Vitamin E), PRO-C™ (antioxidant formula), and one of our high-RNA Rejuvenate!™ superfoods.

†SFB® and VinCare® are registered trademark of Ethical Naturals, Inc.

†† Bioperine® is a registered trademark of Sabinsa Corporation.

ADDITIONAL RESOURCES

New Directions for Preventing Free-Radical Damage

Natural Phytochemical Nrf2 Activators for Chemoprevention

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ELECTROMAGNETIC FIELDS (EMF) AND NUTRITIONAL SUPPLEMENTS

Fred Liers PhD EMF electromagnetic fields nutritional supplementsWe live in a digital world enjoying convenient and limitless access to people, information, and the Internet of Things. What could be the downside? EMF for one.

What is EMF? EMF stands for “Electromagnetic Fields.” Electromagnetic fields encompass an entire spectrum of waves from extremely low frequencies (ELF) and visible light to ultra-high frequencies, such as cosmic rays (ionizing radiation).

What I refer to as “EMF” is the non-ionizing radiation to which we are exposed from cell phones and cell-phone towers, Wi-Fi, cellular data, Bluetooth, smart meters, computers, solar panel inverters, AC-to-DC transformers, power lines, and signals from other digital devices.

Is EMF harmful? Yes, there is a large body of scientific evidence showing EMF can be extremely harmful. Plenty of evidence has existed for decades. Do a search on PubMed. The harms of EMF are not publicized to consumers, especially by companies profiting from the digital and wireless revolutions.

The problem: every year there are more cell phone towers, Wi-Fi networks, “Smart” meters, and solar panel inverters. Soon California will mandate all new homes must have solar power, which means more EMF. Beyond this, there are millions of 5G antennas coming to your region, as part of the most powerful wireless network ever built.

Most health care professionals don’t know much about EMF and the importance of reducing exposure. However, there are a growing number of physicians who understand the dangers of EMF. They can make suggestions for lowering EMF exposure and may also refer you to EMF mitigation experts.

There are four types of EMF building biologists generally test for in homes: 1) Radiofrequency fields (RF), 2) magnetic fields, 3) electric fields, and 4) electromagnetic interference (EMI) or “dirty electricity.” All four types can cause health issues, so it is important to measure and isolate them so you can take action to reduce each type of field, respectively.

I tested my house and office for all four types of EMF—and found all four of them at high levels. I have since mitigated them to safer levels. I continue to find ways to reduce EMF and my exposures to them.

Ways that various types of EMF cause damage to biological systems:

• DNA Damage – Radiofrequency (RF) radiation induces both single- and double-stranded DNA breaks in human and animal cells. When DNA breaks are not properly repaired, the long-term damage results in adverse health effects.

• Voltage Gated Calcium Channels (VGCC) – EMF opens VGCCs causing cells to be flooded with calcium. This excess calcium disrupts multiple pathways, leading to various negative effects, including increased oxidative stress, disrupted nerve cell communication, and heart-related problems.

• Blood Brain Barrier – EMF can open the blood-brain barrier causing toxins or other harmful substances to enter the brain, and for the brain to leak” substances it requires, such as nutrients or neurotransmitters.

• Melatonin Hormone Reduction – EMF suppresses the production of melatonin, which is the antioxidant hormone responsible for repairing the body during sleep. When the body does not properly repair itself at night, problems can arise from immune-related conditions to premature aging.

• Microbiome Disruption – Just as all cells—including those in our body, are electrical, the organisms in our microbiome are electrical, too. There is evidence to show that our microbiome is harmed by EMF.

These are some of the ways that EMF can harm health. When you add them together, you begin to get a picture showing that EMF can cause significant harm to biological systems. Many scientists have suggested how EMF can contribute to almost any health condition from autism to Alzheimer’s disease.

Certain people, myself included, can immediately feel the effects of EMF exposure. Immediate or short-term effects can vary from fatigue, low-energy, and mental fogginess to head and body pains, and ringing in the ears (tinnitus). Terms used to describe the state of being sensitive to EMF are “Electromagnetic Sensitivity” and “Electromagnetic Hypersensitivity” (EHS).

Persons who suffer from EHS may range from 2% to 7% of the population or higher. Yet, whether or not you are “EHS” or feel effects from EMF exposure, science shows your body remains subject to adverse effects, including oxidative damage. That is, just because you do not feel it, does not mean it is not harmful.

Note: there is evidence that certain frequencies of EMF can support health. These often fall into the category of PEMF or “pulsed electromagnetic fields.” Another example: the Schumann resonances (7.82 Hz – 33.8 Hz), which are natural electromagnetic resonances created by lightning discharges from the ionosphere and the surface of the earth. The Schumann resonances are natural earth frequencies to which humans and all life has been exposed for millions of years.

MY EMF STORY

In my case, I never really noticed any problems until I had a solar panel power system installed on my roof-—on two different homes, one in 2014 and the other in 2017. In both cases, I was exposed for relatively long periods at short distances to smart meters and solar inverters, as well as solar-related Wi-Fi equipment.

Shortly after the first installation, I noticed fatigue, inability to concentrate, and pressure in my head. I did not initially make the connection between how I was feeling and the solar installation, which included a DC to AC inverter and two smart meters. I tried to keep my analog electric meter, but the solar company told me only digital smart meters are compatible with the solar power system.

My symptoms improved when I moved my desk away from the wall on whose opposite side the solar equipment was located. Shortly thereafter, we moved to a different home in our metropolitan area. A few years later, we had solar panels installed on our new house. I hoped to avoid symptoms similar to what I had experience previously. No such luck.

After the second solar installation in 2017, I again experienced fatigue, inability to concentrate, as well as pain in my head. I moved my desk and unplugged the solar company’s dedicated Wi-Fi unit that measures solar power generation. I felt better. But over a period of months I developed increasing low-tone tinnitus (ringing in the ears). At first it sounded like a small plane or a truck engine in the distance. The noise grew louder. Then it rumbled night and day. I realized it wasn’t an engine when I discovered the noise was significantly louder in my right ear. Alarmed, I began the process of eliminating possible causes. I finally eliminated all causes—except for EMF.

I read every book I could find about EMF. I read dozens of books, watched videos on the topic, and spoke to EMF experts. During this period my son chose to research EMF for science fair project. His initial idea was to build something for me (like a tinfoil helmet) to reduce my exposure. That idea evolved into measuring the EMF levels emitted by all electronics in our house.

My son’s science project would go on to regionals in our state. Yet for me, the most important thing was how it contributed to our understanding of EMF. It was a launch pad driving us deeper into research, and led to the implementation of many EMF mitigation strategies. Our entire family benefited from it.

EMF science fair project

My son’s 4th-grade science fair project on EMF at Southern Arizona regionals.

EMF electromagnetic fields project

Olin in front of his project board.

It took months, but what we learned helped us take actions to mitigate EMF exposure. My tinnitus began fading and then diminished significantly so that it is not a daily issue for me. This was empowering for me because I took positive actions that made a difference in my health. The process continues because EMF is not going away. I remain vigilant. Yet, I hope my experience can help you reduce your EMF exposure, or avoid developing EMF sensitivity.

I still use cell phones and other digital devices. But I use them less and in much smarter ways. Ways that reduce my EMF exposure. Due to my research and experience with EMF, my awareness of its dangers is such that my thinking on the topic is forever changed. I can never take EMF safety for granted. That is a good thing.

EMF FROM SMART METERS, CELL PHONES, SOLAR INVERTERS, ETC.

Smart meters and DC-to-AC solar inverters can produce high levels of electromagnetic interference (EMI), which is one form of EMF. For more information on EMI, read Samuel Milham’s Dirty Electricity (see resources section below). After reading that book, I considered the possibility that EMI could be contributing to my problems with EMF.

I learned that any device (like an inverter) that converts DC power (say from solar panels) into AC power (home outlets) can add unwanted forms of electricity into the AC power. Clean (60 Hz) electricity becomes polluted by electromagnetic interference. The higher the levels of this EMI or “dirty” electricity, the greater the amount of health effects.

I obtained a broadband EMI meter from Greenwave to measure dirty electricity in my home. I measured EMI levels with the solar system running at midday. Recommended EMI levels are 25–50 millivolts. Yet, every outlet in the house measured almost 2,000 millivolts (1,986  millivolts to be precise!).

I shut off the solar inverter (disabling it and two smart meters) to measure baseline dirty electricity. EMI levels dropped to less than 200 millivolts! This meant one thing: components of our solar system causing high levels (1700+ millivolts) of dirty electricity.

Greenwave EMI EMF meter

Greenwave meter measures dirty electricity in home electrical systems.

My first solution was to purchase multiple plug-in Greenwave EMI filters. I installed them in about 25 outlets throughout my home. They reduced EMI significantly, but they did not reduce it much in the outlets nearest to area that houses the breaker box, solar inverter, and smart meters. A few outlets away from that area exhibited stubbornly high EMI (1,500+ millivolts).

After further research, I called Satic USA. Satic is a solar company that understands that EMI can affect people. They have products designed to condition an electrical system to remove dirty electricity. I  purchased a line conditioner (Super Duty Power Perfect Box) from Satic specifically created to clean EMI from photovoltaic (PV) solar systems.

Note: Satic describes its line conditioners primarily as energy saving devices and protectors of electrical equipment. Clean power is more efficient. Yet, clean, conditioned AC power means reduced EMI. Thus, there is a human health component built-in, if you will.

The Power Perfect Box was installed by an electrician near our breaker box. This line conditioner (containing two harmonic rectifiers) removed many unwanted harmonics and transients induced into our homes’ electrical system by the solar inverter and smart meters.

Above all, I felt better. I could focus better. I slept better. So did everyone else in the house. And my tinnitus began to diminish.

Satic USA EMF EMI dirty electricity

Satic USA’s “Power Perfect Box” is a line conditioner that directly connects to the breaker box where it “cleans” your AC power using two harmonic rectifiers.

I highly recommend obtaining a Power Perfect Box if you have a smart meter, solar power inverter, or dirty electricity (EMI) coming from your utility. Measure baseline dirty electricity in AC outlets using a broadband EMI meter (like Greenwave) after turning off your solar inverter and and smart meters.

Satic makes several types of Power Perfect Box. Which one you need depends on how many harmonic rectifiers your electrical system requires. They also make smaller, lower-cost in-line and plug-in EMF Eliminator devices, which act as high-capacity EMI filters. These provide less protection than a Power Perfect Box, but more than a Greenwave filter. Satic will recommend products based on your unique needs. If you contact Satic to order, speak to Alden, mention my name, and he may offer you a discount.

At Satic’s recommendation, I kept the plug-in Greenwave filters in power outlets throughout my home. Between the line conditioner and the Greenwave filters, EMI now ranges from 15 millivolts to 300 millivolts in most outlets during the day. It is lowest (10–50 millivolts) at night when the solar system is not running.

Note: Many homes only require Greenwave plug-in filters because EMI (dirty electricity) levels are already low to moderate (100-300 millivolts), as measured by a Greenwave meter. However, a residence or office with a typical solar panel installation peaks at about 2,000 millivolts. Thus, a solar-powered home, office, or school may require a dedicated line conditioner to reduce EMI below reductions obtained by plug-in filters.

Multiple Greenwave filters plugged into AC outlets can further reduce EMI. The combination of a line conditioner (like Satic USA’s Power Perfect Box) and plug-in Greenwave filters works well to bring EMI down to safer levels.

Greenwave EMI filters EMF

Greenwave EMI filters plug into household outlets to reduce dirty electricity.

NOT DONE WITH EMF YET

Another EMF issue arose. It seems my exposure to EMF from the home solar system prior to mitigation had led to a general sensitivity to EMF from other sources. That is, even though I had reduced my exposure to fields relating to the solar panel system and its parts (smart meters, solar inverter, solar-related Wi-Fi equipment), I had nevertheless become more sensitive to EMF from cell phones, cellular phone data, Wi-Fi, Bluetooth, vehicle electronics, and other sources.

This sensitivity meant that mitigating dirty electricity (EMI) and reducing the tinnitus, while helpful, would not be sufficient to stop my suffering related to other EMF sources. It would take effort to identify the sources, and then remove or mitigate them.

EMF METERS

Meters are your best friend when it comes to measuring EMF. About the same time I found the Greenwave EMI meter—EMI is just one type of EMF—I obtained three or four meters designed to measure other types of electromagnetic fields.

Some of my favorite meters are the Acoustimeter AM-10 (from EMFields), the Trifield 100XE (from Alpha Labs), and the ME3030B (from Gigahertz Solutions). Each meter can provide different insights into how much EMF exposure you receive from various sources

EMF Acoustimeter AM-10

EMFields AM-10 Acoustimeter is versatile and easy to use.

I began the process of measuring every type of device from iPads to cell phone chargers. I carried meters with me everywhere I went. During his science fair project, I helped my son measure and document readings from EMF sources at multiple distances. This data would be invaluable for my own mitigation efforts.

Overall, EMF levels were far greater than I expected, and from a wider variety of sources not just mobile phones or Wi-Fi routers. For example, wireless toys and cordless phones can be among the worst offenders in the RF frequencies. Even indoor hydroponic systems can generate high levels of dirty electricity.

Trifield 100XE meter EMF

The TriField Meter 100XE is cost-effective.

Using my meters to obtain accurate measurements, I began reducing my exposure to all sources of EMF. The more I reduced EMF exposures, the better I felt. I noticed—and continue to notice—improvements in focus, mental energy, and overall well being.

EMF MITIGATION SOLUTIONS

If my EMF problems are a challenge to solve, then at least there are some upsides. My research has led me to solutions that allow me to heal and avoid symptoms. I am empowered to act upon my knowledge, and to share it.

In many ways, my experience has been a blessing. I am now aware of EMF dangers. While I would not wish anyone to have my experience, I hope that sharing my experience can help even a few people to avoid adverse health effects of EMF.

Here are some actions you can take that have helped me. I recommend you take these actions whether or not you feel symptoms or believe you are not affected by EMF.

• Create a wired Internet network in the home. Computers, laptops, and HDTVs can run on hardwired Ethernet connections. Smart phones and tablets can be hardwired using Ethernet adaptor cords. Use Wi-fi routers infrequently (minimize use), or not at all. Keep routers as far away from living areas as possible.

• Keep smart phones in airplane mode whenever possible. Minimize use of cell phones for calls. Use Air tube headsets and speaker phones whenever possible to provide distance from the device.

• Use an anti-radiation mobile phone case (like SafeSleeve). Avoid using mobile phones in a vehicles like cars and buses (as vehicles act as Faraday cages in which signals just bounce around). Keep away from phone or tablet when downloading data. Turn off Wi-Fi and cellular data on the phone most of the time.

• Never keep mobile phones in pockets or close to the body. Turn phone off or use airplane mode if phone must be kept in proximity to the body.

• Turn off electronics (phones, routers, Bluetooth devices) at night. Keep cell phones and other electronics out of your bedroom. Put your router on timer switch to shut off automatically at 9 or 10 pm.

• Use a landline phone. Yes, landline phone service still exists in most places.

• Obtain a good general EMF meter or two, such as a Trifield, Acoustimer, Cornet, or ME3030B (Gigahertz Solutions). Test your house and your devices.

• Test for electromagnetic interference (EMI) in household outlets using a EMI meter. Install a line conditioner and/or EMI filters (to reduce “dirty electricity”). You can obtain EMI meters and filters from Greenwave or Stetzer.

• Shield smart meters using “radiant barrier” anti-radiation materials, like Satic Shield (from Satic USA) or Reflectix (available at Home Depot). Place shielding on the interior wall opposite the meter. There are also metal meter cages for blocking fields coming from the face and sides of smart meter.

• Consider an in-line conditioner for your electrical system, especially if you have a smart meter or solar panels—or measure significant amounts (300+ millivolts) of dirty electricity on your wiring. I am pleased with Satic USA’s line conditioner (Power Perfect Box) that attaches to my electrical breaker box. If you contact Satic to order a line conditioner, ask to speak to Alden. Mention my name, and he may give you a discount.

• Keep a Faraday bag available for times when you want to block all signals to or from your smart phone or other devices. They are available for less than $20.

The more simple actions I take to reduce EMF, the better I feel. The list of actions I take to reduce EMF exposure grows weekly, it seems. Most of my symptoms have gone away. However, I have no desire to risk them coming back. Whenever possible, I avoid other people using cell phones, reduce time spent in places with Wi-Fi routers, smart meters, cell phone towers, etc.

I have become more sensitive than some of my meters (at least sometimes), so I feel that I am nearly a kind of meter myself in terms detecting the presence and magnitude of electromagnetic fields. Even so, I am often surprised by high EMF readings using my meters. Takeaway: Relying solely on yourself (no matter how sensitive you think you are), is not the best idea.

The most important thing you can do is to obtain a good EMF meter. Measure around your house, your devices, and appliances. Unless you actually have a meter, you will not likely optimize EMF reduction—because you can’t see EMFs. If cost is an issue, certain online stores let you rent EMF meters. Get started today!

BEST SUPPLEMENTS FOR EMF

The first lines of defense against EMF should be increasing distance from EMF sources, and reducing duration of exposure. These make a huge difference for protecting health.

One cannot control all sources of exposure. Neighbors have routers, smart meters, antennas, and other sources of EMF generating electronic pollution (“electrosmog”). Wi-Fi is nearly everywhere these days.

A huge component in EMF defense is nutritional supplements. Why? Because levels of EMF to which we are commonly exposed result in oxidative stress requiring high levels of antioxidants to quench free radicals. Fortunately, HPDI produces some of the best nutritional supplements available for dealing with EMF.

I already had a good diet and took plenty of high-quality nutritional supplements when my problems with EMF started. What I began doing differently was 1) taking generally higher doses of antioxidants and 2) targeting my antioxidant defense systems with specific antioxidant supplements.

By focusing on meeting my higher needs for antioxidants, and by adding specific supplements known for their antioxidant capabilities, I believe I mitigate the worst adverse effects of EMF. Antioxidant supplements noticeably support my ability to function as normally as possible given both my past experiences with EMF, and the ongoing daily needs for antioxidant defense.

I will describe the supplements I believe are most important to take for EMF exposure. I take all these supplements. I include every one of these supplements because each offers a unique benefit. Together they are the most essential formulas to help both with routine, daily exposures to EMF (like Wi-Fi and cell phones), as well as other types of exposures, such as proximity to potent EMF sources from smart meters to cell phone towers.

ANTIOXIDANT & VITAMIN C FORMULAS

The primary type of damage caused by EMF is oxidative stress, the most important type of nutritional supplements to help with free-radical damage are antioxidant formulas, including vitamin C and Nrf2 activator supplements. HPDI offers a complete range of antioxidant and Nrf2 activator products.

PRO-C™ ANTIOXIDANT FORMULA

PRO-C™ is an advanced free-radical protection formula. It performs double-duty as both a potent vitamin C formula and an superb antioxidant formula. It therefore provides important benefits when used in applications requiring Vitamin C and/or free-radical defense, e.g., protocols for general health, anti-aging, rejuvenation, etc.

PRO-C™ contains 500 mg (833% RDA) of buffered non-GMO Vitamin C (in the form of powdered calcium, magnesium, and zinc ascorbates), as well as high-potency Grape Extract (from grape seeds, skins, and pulp), green tea extract, reduced glutathione, n-acetyl-l-cysteine (NAC), r-lipoic acid, coenzyme forms of Vitamin B2 and Vitamin B6, and selenium. Many of these ingredients are powerful Nrf2 activators.

PRO-C antioxidant EMF

PRO-C™ FEATURES

  • HIGHLY EFFECTIVE VITAMIN C FORMULA PLUS ANTIOXIDANTS. A Complete Vitamin C Formula and a Powerful Antioxidant Formula Combined in a Single Supplement!
  • SYNERGISTIC FREE-RADICAL QUENCHING FORMULA. PRO-C Components Work Together To Quench Free Radicals in Your Body. Vitamin C Enables Grape Extract to Function More Effectively, and Conversely Grape Extract Potentiates Vitamin C. Green Tea Extract Boosts ORAC (Oxygen Radical Absorbance Capacity) Value. Read More Below.
  • POWERFUL, NRF2 ACTIVATOR. PRO-C Components of Grape Extract, Green Tea Extract, R-Lipoic Acid, and NAC are all well known Nrf2 activators. These Nrf2 activators are able to stimulate the body’s endogenous production of enzymes such as superoxidedismutase, glutathione peroxidase, catalase, and hemeoxygenase.
  • SUPERIOR, BUFFERED (NON-ACIDIC) FORM OF VITAMIN C. Mineral Ascorbates Never Acidify Your Body, Keeping You pH Balanced. Staying Alkaline Is An Important Element in Maintaining a Healthy Body.
  • RAPID ASSIMILATION. Vegetarian Capsule Form Ensures Rapid Uptake and Assimilation in the Body. You May Also Empty Capsule Contents into Water, Food, or Directly Into Your Mouth, If Desired. Mildly Tart Taste!

If I were to take just one antioxidant/vitamn C formula, PRO-C™ would be it. However, I also take another antioxidant formula called Ultimate Protector. I believe the combination of the two superb formulas works even better for EMF exposure. That’s partly because Ultimate Protector activates Nrf2 in cells allowing them to generate their own antioxidants.

ULTIMATE PROTECTOR™
NRF2 ACTIVATOR FORMULA

ULTIMATE PROTECTOR™ is a next-generation cell protection formula providing Nrf2 protective enzyme activators, high levels of non-GMO Vitamin C, and a full spectrum of exceptionally high potency antioxidants (with an ORAC5.0™ value of 486,000 (per six capsules).

ULTIMATE PROTECTOR supplies nutrients that provide anti-aging, anti-inflammatory, and pain relieving effects, as well as ultra-high levels of antioxidant protection. Damage to cells caused by free-radicals contributes to many degenerative health conditions and to the aging process. This formula effectively supports the body in combating adverse effects of free-radicals.

Ultimate Protector antioxidant EMF

ULTIMATE PROTECTOR™ BENEFITS

  • Anti-aging
  • Anti-inflammatory
  • Pain relief
  • Acts to support the body in the prevention of cardiovascular conditions, hypertension, and support strong immunity.
  • Ultra powerful free radical defense. Helps prevent and mitigate free radical damage that contributes to conditions of poor health.
  • Facilitates the body’s internal production of antioxidant enzymes within cells by supplying natural NRF2 transcription factor activators
  • Ultra effective, high potency, best-in-class antioxidant protection

ULTIMATE PROTECTOR™ FEATURES

  • Plant Based Nrf2 Activators Potentiate the Body’s Internal Antioxidant Systems
  • Ultra-High Antioxidant Potency with an ORAC5.0™ of 486,000 (per six capsules)!
  • Complete Formula Defends Body Against All Five Major Classes of Free Radicals. Provides 30+ Fruit- and Vegetable-Based Antioxidants and Nrf2 Activators to Offer Full Spectrum Protection.
  • Synergistic Formula Combines Effects of Endogenous (Internally Produced) Antioxidants, Exogenous (externally supplied) Antioxidants, and Vitamin C
  • 100% non-GMO Ingredients (includes non-GMO Vitamin C)
  • Veggie Capsules (suitable for vegetarians and vegans)>
  • Six Capsules Daily Provides Optimal Antioxidant Protection

ULTIMATE PROTECTOR™ contains USP-grade non-GMO Vitamin C, AnthoComplete™ (high-ORAC powder: 3000 units/g from Wild Blueberry, Wild Bilberry, Acai, Black Currant Extract, Sweet Cherry, Raspberry, Elderberry, Blackberry, Aronia, Black Soybean Hull Extract, and Blue Corn), CoffeeBerry®Forte® (high-ORAC powder: 6,000 units/g from Coffee Berry), Curcumin (standardized extract with 95% curcuminoids), Trans-Resveratrol (98% from Giant Knotweed), VitaBerry®Plus® (high-ORAC powder: 12,000 units/g from freeze-dried Grape Seed, Wild Blueberry, Wild Bilberry, Cranberry, Tart Cherry, Prune, Raspberry Seed, Strawberry, Trans-Resveratrol, and Quercetin), VitaVeggie® (high-ORAC powder: 6,000 units/g from Broccoli, Broccoli Sprouts, Tomato, Kale, Carrot, Brussels Sprouts, Onion and Spinach), and Bioperine® (a patented black pepper extract that enhances absorption of all ingredients).

By taking Ultimate Protector along with PRO-C™ as my primary antioxidant defense formulas, I maximize my EMF protection by allowing their benefits to function synergistically for greater effect.

OTHER FOUNDATIONAL FORMULAS

I emphasize the importance of antioxidant formulas because they are most effective at quenching the free-radicals caused by exposure to electromagnetic fields. In reality, HPDI’s antioxidant and vitamin C formulas are part of a complete system of HPDI supplements. This three-tiered system includes foundational supplements, enhancement formulas, and condition-specific formulas.

While antioxidant supplements are most important EMF defense, the truth is that antioxidant supplements work far better when they are properly combined with other foundational supplements in the HPDI system. That is, a high-potency multivitamin, essential fatty acids, and a Rejuvenate!™ superfood.

The case for multivitamins is abundantly clear. If you look at the list of harmful effects of EMF (above), you will see that in addition to free-radical damage, EMF harms many essential biological functions in cells. Many of these functions cause cells to require additional vitamins and minerals. These nutrients can be provided by a high-potency multivitamin that provides both optimal amounts (versus minimal amounts) of nutrients, but also proper forms (like coenzyme vitamins) that are most readily assimilated and used by the body. Such forms are immediately used and do not require conversion to usable forms.

MULTIVITAMINS:
HIGH-POTENCY, HIGH-PURITY

HPDI Multivitamins include five different formulas, including a children’s chewable that scales up easily for adults. Two of the primary multivitamins are Multi Two Caps and Mighty Multi-Vite (caps).

Multi Two Caps – A comprehensive multivitamin providing optimal levels of key vitamins, minerals, and cofactors. Includes higher levels of B vitamins.

Mighty-Multi-Vite! – Similar to Multi Two Caps, but offers higher levels of key phytonutrients turmeric, grape extract, and broccoli sprouts powder.

HPDI’s high-potency multivitamins provide:

• B-Complex vitamins: B-Complex vitamins supports enzyme systems. Enzymes are required for all metabolic functions in the body. B vitamins are cofactors required for every enzymatic reaction.

• Minerals. HPDI multivitamins provide 10 or more key minerals. Like B vitamins, minerals support enzyme systems. At the center is every enzyme is an important mineral necessary for its function.

• NAC (N-Acetyl-Cysteine): NAC increases glutathione levels, which are important antioxidant defense in the body.

• Fat-soluble vitamins A, C, D, E, and K. Fat soluble vitamins perform many essential functions, including protection of cell membranes.

Multi Two Caps multivitamin EMF

HPDI MULTIVITAMINS FEATURES

  • COMPLETE, BALANCED CORE NUTRITION. Full-Spectrum of Nutrients Exceptionally Balanced for Supporting Your Health. Foundational Formula Ideal for Providing Essential Foundational  Nutrition. A high-quality multivitamin is the foundation (i.e., core) for a complete nutritional supplement program.
  • RAPID AND EFFECTIVE ASSIMILATION. Incorporates Bioavailable Vitamin and Mineral Carriers Your Body Recognizes and Can Assimilate Immediately. Plus, Multiple Carriers Ensure Assimilation. Tablet or Capsule Forms Rapidly Assimilated!
  • ENERGIZING: Includes Coenzyme Form Vitamins and Krebs Cycle Bionutrients that work with your body to create high energy levels. Full-Spectrum Essential Nutrients Needed For Building, Supporting, and Maintaining Excellent Health.
  • HIGH PURITY. Among the Purest Available Multivitamin supplements. Carefully Designed To Exclude Common Allergens, and Exclude or Minimize Excipients, Additives, and Fillers.

If I could only take a single supplement daily, it would be a multivitamin. I personally prefer HPDI’s Mighty Multi-Vite!. But Multi Two actually provides higher levels of important B vitamins.

Multivitamins are too vital not to take daily. Fortunately, you are not limited to taking a single supplement. That is why I put antioxidant and vitamin C formulas at the top of the list for protection against EMF. The truth is, however, that both a multivitamin and antioxidants are essential for foundational nutrition. You need both to ensure optimal protection from EMF. There are a few more critical nutrients you need, as well.

ESSENTIAL FATTY ACIDS (EFA)

Another important foundational supplement is essential fatty acids (EFA). Essential fats are critical for cellular function, cell membrane health, combating inflammatory processes, and overall health. Essential fats are necessary for cellular health. Yet, because EMF creates problems at the cellular level, it is even more vital to obtain essential fats to help cells function at their best.

People overlook the importance of essential fats. That is, I notice that multivitamins and antioxidants are far more likely to be prioritized, and therefore taken daily. Fair enough, because I prioritize those supplements too. Yet, we neglect essential fats at our peril. That is why I take EFAs daily, too.

IMPORTANT FUNCTIONS OF ESSENTIAL FATTY ACIDS (EFA)

• Regulate steroid production and hormone synthesis
• Regulate pressure in the eyes, joints, and blood vessels
• Regulate response to pain, inflammation, and swelling
• Mediate Immune Response
• Regulate bodily secretions and their viscosity
• Dilate or constrict blood vessels
• Regulate smooth muscle and autonomic reflexes
• Are primary constituents of cellular membranes
• Regulate the rate at which cells divide
• Necessary for the transport of oxygen from the red blood cells to tissues
• Necessary for proper kidney function and fluid balance
• Prevent red blood cells from clumping together
• Regulate nerve transmission

When by diet or supplementation, you consume the correct ratios and amounts of essential fatty acids, then you allow the EFAs to act in ways critical for these functions. For more detailed information, see Dr. Hank’s article, “The Truth About Essential Fatty Acids” (December 2017).

HPDI’s essential fatty acids formula is Essential Fats Plus E. Essential Fats Plus E provides essential fasts in the proper amounts and ratios for good health.

Essential Fats Plus E EMF

Essential Fats Plus E contains eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) (important essential omega-3 fatty acids), gamma linolenic acid (GLA) (an important essential omega-6 fatty acid), and mixed tocotrienols and tocopherols (Vitamin E).

The EPA and DHA are in the form of triglycerides derived from marine lipids (using patented flash molecular distillation) and the GLA is from cold-pressed borage seed oil. The mixed tocotrienols and tocopherols derive from rice bran oil, and are included in the softgel capsules for antioxidant protection of the polyunsaturated oils.

Omega-3 and omega-6 fatty acids are known to play important roles in the formation of prostaglandins. The prostaglandins are important cellular regulators controlling inflammatory processes and pain in the body.

Fish oils may be useful adjuncts in protocols for 1) Cardiovascular disease, 2) Hypertension, 3) Arthritis and inflammatory disorders, 4) Psoriasis and skin problems, 5) Diabetes mellitus, 6) Depression, and 7) Kidney disease. GLA may be a useful adjunct in protocols for 1) Multiple Sclerosis and 2) Arthritis. Research indicates that in a balanced formula there are synergistic effects between EPA, DHA, and GLA. For example, it is known that EPA inhibits the conversion of GLA into pro-inflammatory (and pain-causing) arachidonic acid.

Research indicates that in a balanced formula there are synergistic effects between EPA, DHA, and GLA. For example, it is known that EPA inhibits the conversion of GLA into pro-inflammatory (and pain-causing) arachidonic acid.

Because these fatty acids have many double bonds that are prone to oxidation, Vitamin E is included in the forms of mixed tocotrienols and tocopherols. In addition, these forms of Vitamin E have been shown to reduce arterial plaques and enhance blood flow, inhibit thromboxane and platelet aggregation, protect serum lipids from oxidation (including LDL and HDL), reduce carotid stenosis (narrowing) and prevent stroke, trap harmful nitrogenous radicals, act as anti-proliferative agents, and provide powerful oxidative defense for the skin.

Essential fatty acids are considered “essential” for all the reasons described. They are so critical for proper cellular function that not having sufficient essential  fats  (or the proper ratios) can impair important processes in the body. I believe EMF exposure puts additional stress on cells such that essential fats are even more necessary. So take an EFA supplement like Essential Fasts Plus E every day.

HYDROGEN SUPPLEMENTS

Hydrogen supplements can be very helpful for preventing or mitigating oxidative damage by EMF. I have recently written about two hydrogen formulas that support antioxidant defenses: Megahydrate and Active H2 Ultra. (See “Hydrogen Supplements – Active H2 Ultra and Megahydrate“)

MEGAHYDRATE

Megahydrate (powder and capsules) provides H-, or the hydrogen anion, which provides lasting antioxidant protection. It this regard, it is highly effective at quenching free radical (even better than molecular hydrogen), greatly enhances the production of ATP (cellular energy) in the body, retains its antioxidant capacity for extended periods, and is the key unlocking the potential of water as the medium for nutrient replenishment and waste removal at the cellular level.

The active ingredient in Megahydrate is silica hydride. One very important characteristic of the antioxidant capacity of silica hydride is that it is the only antioxidant that does not turn into a free radical (i.e., oxidant) once it has neutralized a free radical by donating its electron. Negatively-charged hydrogen turns into molecular hydrogen gas and/or turns into water.

Megahydrate antioxidant EMF

One daily dose of Megahydrate has more antioxidant power than hundreds of glasses of fresh vegetable and fruit juices, broccoli, brussel sprouts, leafy greens, and other foods rich in antioxidants and prevents free radical damage.

Studies show that Megahydrate increases energy production (adenosine triphosphate or ATP) by up to four times.

BENEFITS OF MEGAHYDRATE

  • Contains Hydrating Silica Microclusters®
  • Extremely Powerful Antioxidant
  • Recycles other Key Antioxidants in the Body
  • Extremely Safe and Non-Toxic
  • Easily Accesses All Cells in the body
  • Increases Cellular ATP Production by up to a factor of 4 times
  • Readily Converts NAD+ to NADH
  • Reduces Pain & Inflammation
  • Exhibits Powerful Anti-Aging Properties
  • Protects and Repairs DNA
  • Neutralizes Harmful Toxins like Fluoride, Chlorine, etc.
  • Protects Against and Repairs Radiation Damage
  • Increases Absorption of other Supplements
  • Lowers surface tension of water you drink leading to improved detoxification
  • Removes Heavy Metals from the Body
  • Balances pH or Alkalizes the body
  • Increases Zeta Potential of Human Cells
  • Increases Cellular Hydration
  • Very Stable – Works Over Extensive Time Periods
  • Reduces Lactic Acid Buildup During Intense Workouts
  • Protects Telomeres by allowing cells to exceed the Hayflick limit by 4–5 times

I drink Megahydrate daily in water. I find it very energizing and it seems to potentiate the other antioxidant supplements. Usually I drink it mixed with Active H2 Ultra, which provides molecular hydrogen. But sometimes I drink Megahydrate all by itself, as it is an excellent standalone hydrogen formula.

ACTIVE H2 ULTRA

ACTIVE H2® ULTRA is my favorite molecular hydrogen formula. In fact, I almost always add this tablet into water that is already infused with Megahydrate. That is, I believe this formula works best when taken together with Megahydrate. I like this combination “fizzy” drink so much, I created a video showing how to make it.

Active H2 Ultra tablets provides abundant hydrogen molecules that are uniquely found in fresh, raw, living foods and are essential to any serious antioxidation program.

A unique and patent pending combination of magnesium and supporting nutrients are the only active substances in Active H2 Ultra. This distinguishes it from the existing synthetic chemical formulas as well as the use of electrolysis (as in water ionizers) to generate molecular hydrogen.

The natural, proven Active H2 Ultra formula consists of a proprietary blend of pure magnesium metal, malic acid, tartaric acid, stearic acid, and dextrose that act synergistically in water to generate Molecular Hydrogen and electron-rich potential (-ORP).

Active H2 Ultra EMF

BENEFITS OF ACTIVE H2 ULTRA

  • Unsurpassed antioxidizing effects indicated by strong negative-ORP
  • Scavenging of cytotoxic oxygen radicals and highly reactive hydroxyl radicals
  • Reduction of oxidative stress and inflammation
  • Regulation of various gene expressions and protein-phosphorylations
  • A synergistic complement to other cellular antioxidants like vitamin C, vitamin E, and glutathione
  • Enhanced endurance in daily activity and strenuous exercise
  • Clinically proven to reduce lactic acid levels during strenuous workouts
  • Reduced water cluster size for improved cellular hydration

    ACTIVE H2 ULTRA FEATURES

  • -700 mV ORP in 1 liter of pure water
  • Increases cellular hydration
  • Regular use heightens physical and mental energy
  • Supports mitochondrial ATP (energy) production
  • Alkalizing minerals (magnesium)
  • Quickly and cleanly dissolves in less than 1 minute – no waiting around for dissolution.
  • You can drink  as soon as the tablet dissolves – thereby getting greater amount of hydrogen than in tablets that take longer to dissolve.

Hydrogen is emerging among the top super-nutrition discoveries of the 21st century. I am not waiting to gain its benefits. Just as many athletes are using it to gain a competitive advantage, I take Active H2 Ultra and Megahydrate for their effective antioxidant benefits and much more, including EMF protection. And so should you.

RESTORE

RESTORE is one of those products that go beyond anything else I’ve seen in terms of what is can do and how it does it. In fact, I recently published an article devoted solely to Restore (see “Restore Gut Health Formula + Video”).

The reason I include RESTORE in my list of top formulas for EMF exposure is because it protects the integrity of the gut barrier or tight junctions, supports the communications system in the gut microbiome, and acts as a fertilizer for the microbiome itself. These are important effects because EMF breaks down tight junctions, interferes with microbiome communications (as gut bacteria use their own weak EMF signals to communicate), and reduces microbiome health.

restore gut health EMF

RESTORE is a soil-derived, scientifically backed mineral supplement that creates a firewall against toxins entering the gut wall. RESTORE helps create a biological environment for “good” gut bacteria to grow and flourish in order to support improvement of overall health.

RESTORE is not a probiotic. It is not a prebiotic. Rather, it is a carbon rich, alkaline liquid, with lignite derived trace organics and essential trace amino acids, that promotes an optimal environment in the gut. With 70% of the immune system located in the gut, this optimal gut environment leads to great gut health.

Research has shown RESTORE to be non-toxic and to support the tight junction cells of the gut lining. Additionally, RESTORE has been shown both in the laboratory and clinically to help support the functioning of the gut barrier and improve gut health. In experiments, toxins like herbicides and gluten have been shown to degrade the gut barrier. RESTORE has been shown to promote the strengthening of the tight junction gut barrier in small and large gut membrane cells for gut health.

One of the main elements in RESTORE is the lignite extract. Lignite comes from decomposed prehistoric matter. As plants decompose, they first form peat, which then turns into humate, then lignite, then leonardite and finally to coal. All of these are rich in carbon. One of the differences between all of these elements is the amount of time and pressure have been applied to them.

OTHER IMPORTANT SUPPLEMENTS MITIGATING EMF EFFECTS

My list of favorite supplements for EMF could be much longer. I will mention two other types of supplements I think can be useful for most people. One is magnesium and the other is C-60 (or Carbon-60).

MAGNESIUM

Magnesium is critical for supporting and enabling at least 400 enzymes in the body that are needed for the vital reactions in cells. EMF can damage or impair enzyme function. Therefore sufficient magnesium is essential for optimal cell function. One known problem is that most people are deficient in magnesium. When enzyme systems lack magnesium, they fail to properly function, resulting in many problems in the body, including lower energy production (ATP) and deficient metabolism.

Magnesium also balances calcium in cells. When EMF causes voltage gated calcium channels (VGCC) to open flooding cells with calcium, the presence of magnesium may help because one of the functions of magnesium is preventing cellular calcium imbalances. Not to mention the role of magnesium in energy production—as energy is required to pump excess calcium out of cells.

One of my favorite magnesium products is MYO-MAG. MYO-MAG is an advanced, synergistic magnesium formula that provides therapeutic levels of magnesium, plus nutrients that support the body’s utilization of magnesium.

MYO-MAG provides magnesium in the form of malate and diglycinate, as well as Vitamins B1, B2, and B6 (including coenzyme forms of these vitamins). The formula is buffered with a small amount of magnesium carbonate, and includes some manganese for mineral balance.

MYO-MAG therefore is a highly effective oral magnesium supplement with benefits that include less fatigue and greater energy, improved metabolic functions, cardiovascular support, nutrition for muscles, reduced spasms or cramps, help for migraine headaches, and many others.

The formula not only supports metabolism, but also cellular energy production (ATP) and optimal cellular function. It allows for rapid uptake and absorption of easily assimilated forms of magnesium. It also provides critical nutrients supporting energy production in the body.

Because MYO-MAG rapidly boosts magnesium levels, individuals usually notice greater physical and mental energy, reduced fatigue, and often a greater sense of overall well being.

Myo-Mag EMF

MYO-MAG provides magnesium important for cellular energy.

MYO-MAG contains ingredients participating in the production of ATP. One vegetarian capsule contains 100 mg of magnesium and 440 mg of l-malic acid. Vitamins B1 and B2 are included both in standard and phosphorylated forms. Also included are Vitamin B6 in its phosphorylated form only, manganese (because high levels of magnesium can deplete the body of it), magnesium carbonate (a malic acid buffer), and glycine as the carrier for a portion of the magnesium and for the manganese. MYO-MAG is contained in a vegetarian capsule to ensure rapid assimilation.

Supplementing the diet with magnesium and malic acid may reverse conditions of low energy. Suggested daily amounts include 300-600 mg of magnesium and 1200–2400 mg of malic acid. Taking 3 to 8 MYO-MAG capsules daily can provide these amounts. Beyond this formula, HPDI offers a complete range of magnesium formulas, including Ancient Minerals topical magnesium chloride products (oil, flakes, and gel).

CARBON-60

Carbon-60 or C-60 is an experimental supplement providing extremely high antioxidant capacities. Carbon-60 provides research grade Carbon-60 Fullerenes (0.8 mg/ml) in organic olive oil. While this formula is formulated for research, it is known to be among the most powerful antioxidants available. The structure of the Fullerene allows for a large number of electrons to be held and repeatedly donated for the purpose of quenching free radicals. It therefore offers unrivaled  antioxidant capacity in the body.

I will be talking a lot more about Carbon-60 in coming months. Suffice it to say that the research is showing that C-60 may be the future of antioxidant nutrition.

CONCLUSION

Few people have paid much attention to the dangers of EMF until recently. There is growing awareness that EMF contributes to health problems, as well as the mechanisms by which EMF damages the body. Given the rise in health conditions likely to be related to EMF exposure, it makes sense to take action now, rather than unnecessarily risking harmful effects of exposures.

There are many actions you take to protect yourself and your family. These include turning off Wi-Fi, putting cell phones on airplane mode, shielding smart meters (or keeping your analog meters), increasing distance from EMF sources, and reducing duration of exposure.

Taking nutritional supplements providing good levels of antioxidant nutrients and supporting metabolic functions makes a lot of sense, too. Supplements have helped me be healthier and recover faster from EMF exposures. They likely can help you and yours do the same.

EMF damages your cells daily. Take action to protect yourself!

RESOURCES

Blog Articles

HYDROGEN SUPPLEMENTS – ACTIVE H2 ULTRA AND MEGAHYDRATE

HYDROGEN SUPPLEMENTS – MAKE HYDROGEN DRINKS

RESTORE GUT HEALTH FORMULA + VIDEO

THE TRUTH ABOUT ESSENTIAL FATTY ACIDS

Products

Foundational Supplements

HPDI antioxidant & vitamin C formulas

PRO-C™

Ultimate Protector

HPDI Multivitamins

Multi Two

Mighty Multi-Vite!

Essential Fats Plus E

Hydrogen Supplements

Megahydrate

Active H2 Ultra

Gut Health Formulas

Restore

Myo-Mag (magnesium)

Ancient Minerals topical magnesium

Carbon-60

Scientific Articles, Books, and Video

Allen, Russ. Electrocution of America: Is Your Utility Company Out to Kill You? Kindle Edition. Glenmore Books, 2008.

Austrian Medical Association EMF Working Group (AG-EMF). Guideline of the Austrian Medical Association for the Diagnosis and Treatment of EMF-Related Health Problems and Illnesses (EMF Syndrome). 2012. Web. Feb. 2018. <http://www.vagbrytaren.org/Guideline%20%20AG-EMF.pdf >

Bawden-Smith, Jason. In the Dark: New Ways to Avoid the Harmful Effects of Living in a Technologically Connected World. Australia: Major Street Publishing Pty Ltd, 2016.

Belyaev, Igor, et al. “EUROPAEN EMF Guideline 2016 for the Prevention, Diagnosis, and Treatment of EMF-Related Problems and Illnesses.” Reviews on Environmental Health, vol. 31, no. 3, 2016, pp. 363-97.

BioInitiative Report: A Rationale for a Biologically Based Public Exposure Standard for Electromagnetic Radiation. Cindy Sage and David O. Carpenter, eds. The BioInitiative Working Group. Sage Associates, 2012. <www.bioinitiative.org>

Blank, Martin, PhD. Overpowered: What Science Tells Us About the Dangers of Cell Phones and Other Wi-Fi Age Devices. New York: Seven Stories Press, 2015.

Burrell, Lloyd. EMF Protection Free Report. eBook. ElectricSense: 2015.

Burrell, Lloyd. Long Term EMF Protection: Start Feeling Better Today. eBook. ElectricSense, 2013.

Calvente, Irene, et al. “Characterization of Indoor Extremely Low Frequency and Low Frequency Electromagnetic Fields in the INMA-Granada Cohort.” PLoS One, 2014, vol. 9, no. 9, e106666. Web. Feb 2018. <http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0106666>

Davis, Devra, PhD, MPH. Disconnect: The Truth About Cell Phone Radiation. New York: Environmental Health Trust, 2013.

Federal Communications Commission. Radio Frequency Safety: FCC Policy on Human Exposure to Radio Frequency Electromagnetic Fields. Web. Feb. 2018. <https://www.fcc.gov/general/radio-frequency-safety-0>

Full Signal: The Hidden Cost of Cell Phones. DVD. Directed by Talal Jabari. Capture Productions, 2009.

Generation Zapped. DVD. Directed by Sabine El Gemayel. Zapped Productions, 2017. <www.generationzapped.com>

Gittleman, Ann Louise. Zapped: Why Your Cell Phone Shouldn’t be Your Alarm Clock and 1,268 Ways to Outsmart the Hazards of Electromagnetic Pollution. New York: Harper Collins, 2010.

Halpern, Dr. Jonathan, PhD. Electromagnetic Radiation Survival Guide: Step-by-Step Solutions. Kindle Edition. CreateSpace Independent Publishing, 2014.

Hardell, L. and C. Sage. “Biological Effects from Electromagnetic Field Exposure and Public Exposure Standards.” Biomedicine & Pharmacotherapy, vol. 62, no. 2, 2008, pp. 104-109.

Hardell, Lennart. “World Health Organization, Radiofrequency Radiation and Health – A Hard Nut to Crack (Review).” International Journal of Oncology, vol. 51, no. 2, 2017, pp. 405-413.

International Commission on Non-Ionizing Radiation Protection (ICNIRP). “ICNIRP Guidelines for Limiting Exposure to Time-Varying Electric, Magnetic, and Electromagnetic Fields (Up to 300 GHz).” Health Physics, vol. 74, no. 4, 1998, pp. 494-522.

International Institute for Building Biology. Standard of Building Biology Testing Methods. IBE SBM-2008C V3.6. 2008. Web. Feb. 2018. <http://hbelc.org/pdf/standards/SBM-2008C-v3.6.pdf>

INTERPHONE Study Group. “Brain Tumor Risk in Relation to Mobile Telephone Use: Results of the INTERPHONE International Case-Control Study.” International Journal of Epidemiology, vol. 39, no. 3, 2010, pp. 675-94.

Johnson, Jeromy. Wireless Wake-Up Call. TEDxBerkeley. 2016.

Kundi, M., L. Hardell, C. Sage, and E. Sobel. “Electromagnetic Fields and the Precautionary Principle.” Environmental Health Perspectives, vol. 117, no. 11, 2009, pp. A484-5.

Michigan State University. “Electromagnetic Fields Affect Human Cells.” ScienceDaily. ScienceDaily, 16 October 2000. Web. Feb. 2018.
>www.sciencedaily.com/releases/2000/10/001016073704.htm>

Mild, K.H., M. Repacholi, E. Deventer, and P. Ravazzani, eds. International Workshop on EMF Hypersensitivity Conference Proceedings: Electromagnetic Hypersensitivity, 25-27 Oct. 2004, Prague, Czech Republic. Geneva, Switzerland: World Health Organization Press, 2006.

Milham, Samuel, MD, MPH. Dirty Electricity: Electrification and the Diseases of Civilization. Second Edition. Bloomington, Indiana: iUniverse, 2012.

Mobilize: A Film About Cell Phone Radiation. DVD. Directed by Kevin Kunze, performances by Gavin Newsom and Steve Wozniak. Dreamscape Media, 2016.

Ober, Clinton, Steven T. Sinatra, and Martin Zucker. Earthing: The Most Important Health Discovery Ever. Colorado Springs, CO: Basic Health Publications, 2014.

Phillips, J.L., N. P. Singh, and H. Lai. “Electromagnetic Fields and DNA Damage.” Pathophysiology, vol. 16, nos. 2-3, 2009, pp. 79-88.

Pineault, Nicolas. The Non-Tinfoil Guide to EMFs: How to Fix Our Stupid Use of Technology. Montreal, Canada: N&G Media, Inc., 2017.

Pinsky, Mark. The EMF Book: What You Should Know About Electromagnetic Fields, Electromagnetic Radiation, and Your Health. New York: Warner Books Incorporated, 1995.

Plourde, Elizabeth PhD and Marcus Plourde PhD. EMF Freedom: Solutions for the 21st Century Pollution. 3rd Ed. Irvine, California: New Voice Publications, 2016.

Resonance: Beings of Frequency. DVD. Directed by James Russell. Jansen Media, 2016.

Simkó, M., and MO Mattisson. “Extremely Low Frequency Electromagnetic Fields as Effectors of Cellular Responses in Vitro: Possible Immune Cell Activation.” Journal of Cell Biochemistry, vol. 93, no. 1, 2004, pp. 83-92.

Starkey, S.J. “Inaccurate Official Assessment of Radiofrequency Safety by the Advisory Group on Non-Ionising Radiation.” Reviews on Environmental Health, vol. 31, no. 1, 2016, pp. 493-503.

Take Back Your Power: Investigating the Smart Grid. DVD. Directed by Josh del Sol. BigPitcher Films (Canada), 2013.

Waugh, Jim. Living Safely with Electromagnetic Radiation: A Complete Guide for Protecting Your Health. Richmond Hill, Canada: Firefly Books, 2010.

World Health Organization (WHO). Electromagnetic Fields and Public Health: Electromagnetic Hypersensitivity (EHS). Fact Sheet no. 296. 2005. <http://www.who.int/peh-emf/publications/facts/fs296/en/>

World Health Organization (WHO). International Agency for Research on Cancer (IARC). IARC Classifies Radiofrequency Electromagnetic Fields as Possibly Carcinogenic to Humans. Press Release. 31 May 2011. <http://www.iarc.fr/en/media-centre/pr/2011/pdfs/pr208_E.pdf>

 

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PRO-C ANTIOXIDANT FORMULA UPDATE + VIDEO

Dr. Hank Liers, PhD pro-c™ pro-c super antioxidant formulaFred Liers PhD pro-c antioxidant vitamin c nrf2 formulaLooking for an advanced antioxidant formula? Already using or recommending vitamin C? Curious about cellular Nrf2 activation? Look no further than PRO-C™.

PRO-C™ is among the most effective antioxidant formulas available. It is an HPDI foundational supplement that works most effectively when used with multivitamins, essential fats, and superfoods. However, it is also an excellent standalone formula that can rapidly provide the body with extremely high protection from free radicals.

We ourselves have taken PRO-C daily for many years with excellent results. Our personal experience together with detailed feedback from health professionals and end-users affirms the effectiveness of PRO-C as a super-antioxidant–vitamin C-Nrf2 activator formula.

PRO-C provides 500 mg of buffered vitamin C per capsule (buffered with calcium, magnesium, and zinc) along with grape extract (seed, skin, pulp) and green tea extract (95% polyphenols). In addition, we include a special combination of the “network antioxidants” l-glutathione (reduced), n-acetyl-l-cysteine (NAC), r-lipoic acid, and selenium. Vitamin B2 and Vitamin B6 in coenzyme forms support the enzymatic effectiveness of the “network antioxidants”. The formula works so well because this combination of ingredients leverages the antioxidant power of vitamin C, grape extract, green tea extract, and the other nutrients to act synergistically in order to maximize effectiveness.

FORMULATION HISTORY AND THE SCIENCE BEHIND PRO-C™

What you may not know is the history of the development PRO-C and the scientific knowledge on which Dr. Hank Liers based his formulation of it.

Dr. Hank formulated his first product in 1989. It was a potent antioxidant formula he called PYC-C™ (sounds like “pixie”). PYC-C consisted of a combination of buffered Vitamin C (including magnesium, calcium, and zinc ascorbates) and pycnogenols from pine bark.

Much of the scientific research data Dr. Hank collected during the development of PYC-C regarding oligomeric proanthocyanidins (OPC) he later incorporated into an article (currently published on this blog) titled “Review of Scientific Research on Oligomeric Proanthocyanidins (OPC)” (rev. 2017)

By 1997 Dr. Hank had gathered a great deal of new scientific information regarding green tea catechins and the nutrients termed “network antioxidants” by Dr. Lester Packer, director of Packer Lab at University of California, Berkeley. Beyond this information, Dr. Hank studied additional research regarding how various nutrients worked together synergistically. At that point, he was ready to formulate the new, improved PRO-C™ super antioxidant formula.

PRO-C combines the ingredients of PYC-C (now known as OPC-C™) and uses grape pulp, skin, and seed extract with green tea extract (with high polyphenols >95% and EpiGalloCatechinGalate (EGCG) >45%), n-acetyl-l-cysteine (NAC), reduced glutathione (GSH), R-lipoic acid, selenium, and coenzyme Vitamins B2 and B6.

PRO-C super antioxidant formula 180 cap 90 cap

HPDI launched PRO-C™ in late 1997. It rapidly became one of our best-selling products. Our customers raved about how effective it was for them if they felt like they were “coming down with something” (like a cold, flu, virus, infection, etc.). Greater skin elasticity greatly helped pregnant women avoid stretch marks and episiotomies. Today, we highly recommend its use together with our other Foundational Supplements to ensure optimal health and anti-aging effects.

THE PRO-C™ SUPER ANTIOXIDANT FORMULA

PRO-C™ super antioxidant formula is extremely synergistic, especially in so far as it increases the body’s ability to quench free radicals in its aqueous (i.e., water-based) compartments. Because antioxidants may become free radicals themselves after they have done their job, the body has developed an elaborate system for recovery of oxidized antioxidants.

 

Dr. Lester Packer was the primary researcher investigating the synergistic character of antioxidants. He made this statement in his interview with Dr. Richard Passwater after publication of Packer’s The Antioxidant Miracle (1999):

[The major theme of] The Antioxidant Miracle is that antioxidants work in a coordinated manner. They interact with one another, and this interaction, which we like to call the antioxidant network, is very important to the overall antioxidant defense that we possess. The key members of the antioxidant network are vitamin E and vitamin C, but there are other participants in this network. These are thiol antioxidants, antioxidants that contain sulfur groups in the body. Glutathione perhaps is the best known of these, but there are other sulfur-containing antioxidants that also are very important.”

Dr. Packer continues:

“This whole antioxidant network works like an orchestra depending on individuals who have, of course, different complements of antioxidants depending upon their nutritional regimens and the individuality of their own body metabolisms. The idea behind having a network of antioxidants is that if one antioxidant happens to be deficient the others can compensate and still keep the antioxidant defense system strong.”

The following diagram shows some of the relationships in the antioxidant network and how they support each other.

Lester Packer antioxidant network diagram Figure 1 – Dr. Packer’s Antioxidant Network

We see, for example, reduced glutathione (GSH) has the ability to reduce oxidized Vitamin C back to its unoxidized state. Vitamin C reduces oxidized Vitamin E back to its unoxidized state, and both reduces glutathione and spares it for other important functions, including detoxification and immune enhancement.

Many polyphenols (e.g., oligomeric proanthocyanidins (OPCs), anthocyanidins and catechins) found in red grape and green tea extracts spare Vitamin C and glutathione in the body, as well as operate as powerful antioxidants, anti-inflammatories, and connective tissue strengtheners.

grapes grape extract antioxidant

Grapes provide antioxidant nutrients such as polyphenols, OPCs, anthocyans, and resveratrol.

R-Lipoic Acid (see abstracts below) operates as an antioxidant both in its oxidized and reduced states, reduces the oxidized forms of both Vitamin E and Vitamin C, and and has been shown to enhance glutathione levels. Because several of these substances are able to protect Vitamin E contained in cell membranes, this combination also has a significant beneficial effect on the fat soluble antioxidant status of the body!

The nutrients in PRO-C have been carefully selected and balanced to provide optimal effects, especially as related to free radical protection, detoxification, immune system enhancement, connective tissue strengthening, and reduction of inflammation. PRO-C therefore provides outstanding nutritional support in a wide variety of conditions of poor health, as well as acts to support and maintain a state of health and well-being.

It the last several years the research results on Nrf2 activators have become well known and products developed that take advantage of these nutrients. For details see our blog article Natural Phytochemical Nrf2 Activators for Chemoprevention. Researchers have been studying specifically how enzyme-activating substances such as OPCs and anthocyans activate a transcription factor known as Nrf2 that causes the body to endogenously produce higher levels of a wide variety of protective enzymes including superoxide dismutase (SOD), catalase, and glutathione peroxidase.

Although we did not know about Nrf2 activators in 1997 when we formulated PRO-C, we have subsequently learned that four of the ingredients in the formula have powerful Nrf2 activity. These include grape seed extract, green tea extract, NAC, and r-lipoic acid. With this knowledge, we now understand that PRO-C provides both powerful external antioxidants (with extremely high ORAC5.0 values) that support redox cycles within the body, but also provides ingredients that allow the body to endogenously produce powerful protective enzymes for even greater free-radical protection and health.

PRO-C™ ANTIOXIDANT FORMULA INGREDIENTS

PRO-C contains buffered vitamin C (in the form of powdered calcium, magnesium, and zinc ascorbates), high-potency grape extract (from grape pulp, skins, and seeds), green tea extract (with>95% polyphenols and >45% EGCG), reduced glutathione, N-Acetyl-L-Cysteine (NAC), R-lipoic acid, coenzyme forms of vitamin B2 (R5P) and vitamin B6 (P5P), and selenium.

Below we will discuss each ingredient and show some of the research that confirms its effectiveness.

VITAMIN C

Vitamin C typically is called l-ascorbic acid or ascorbate and is an essential nutrient for humans and other animal species. The term “vitamin C” refers to a number of vitamins that have vitamin C activity in animals, including ascorbic acid and its salts (e.g., magnesium ascorbate, calcium ascorbate, sodium ascorbate, etc.), and some oxidized forms such as dehydroascorbate and semidehydroascorbate.

Vitamin C is known to perform many critical functions within the body involving detoxification, tissue building, immune enhancement, pain control, and controlling or killing pathogenic organisms. It is also known to be helpful for wound and bone healing, healthy skin and eyes, fighting infections, stress control, toxic exposure, and repairing damaged tissue of all types. For much more information on the many benefits of Vitamin C see our blog article Vitamin C – An Amazing Nutrient.

Below are two abstracts that show some of the beneficial effects of Vitamin C when used with other network antioxidants:

ABSTRACT 1:
Exhaustive physical exercise causes oxidation of glutathione status in blood: prevention by antioxidant administration.
Sastre J, Asensi M, Gasco E, Pallardo FV, Ferrero JA, Furukawa T, Vina J
In: Am J Physiol (1992 Nov) 263(5 Pt 2):R992-5

We have studied the effect of exhaustive concentric physical exercise on glutathione redox status and the possible relationship between blood glutathione oxidation and blood lactate and pyruvate levels. Levels of oxidized glutathione (GSSG) in blood increase after exhaustive concentric physical exercise in trained humans. GSSG levels were 72% higher immediately after exercise than at rest. They returned to normal values 1 h after exercise. Blood reduced glutathione (GSH) levels did not change significantly after the exercise. We have found a linear relationship between GSSG-to-GSH and lactate-to-pyruvate ratios in human blood before, during, and after exhaustive exercise. In rats, physical exercise also caused an increase in blood GSSG levels that were 200% higher after physical exercise than at rest. GSH levels did not change significantly. Thus, both in rats and humans, exhaustive physical exercise causes a change in glutathione redox status in blood. We have also found that antioxidant administration, i.e., oral vitamin C, N-acetyl-L- cysteine, or glutathione, is effective in preventing oxidation of the blood glutathione pool after physical exercise in rats.

ABSTRACT 2:
The effect of glutathione and vitamins A, C, and E on acute skin flap survival.

Hayden RE, Paniello RC, Yeung CS, Bello SL, Dawson SM
In: Laryngoscope (1987 Oct) 97(10):1176-9

Vitamins A, C, and E act as antioxidants and as free radical scavengers in biological systems. Glutathione is involved in several reactions in vitamin metabolism and also plays an important role in cell membrane protection against lipid peroxidation by free radicals. We sought to use these natural defense mechanisms against oxygen free radicals formed during reperfusion of ischemic skin flaps. An acute axial random skin flap model was utilized in the rat. Vitamins or glutathione were administered by oral gastric tube or intravenously in the perioperative period, and survival of the flap was measured at 1 week. Glutathione, beta-carotene, ascorbic acid and alpha-D- tocopherol showed mean flap survival of 84% to 89%, each of which was significantly improved over saline controls (67% p less than .0005). The mechanisms and biochemistry of these vitamins, and their interactions with other vitamins and with glutathione, are discussed, along with clinical implications of free radical scavenging and skin flap survival.

GRAPE EXTRACT

Grape extract (seeds, skin, pulp) contain highly bioavailable bioflavonoid complexes that in research studies have been shown to have powerful antioxidant capability. The Oligomeric Proanthocyanidins (OPCs) in grape seed extract are able to strengthen collagen fibers in aging or damaged connective tissue and can act as a preventative against connective tissue degradation.

Some research indicates that anthocyans, which are found in extracts of grape skin and stems (but not in grape seed extract), can reduce oxidized glutathione while at the same time become reduced themselves. In addition, extracts of grape skin and stems (but not those of grape seed extract) contain a material called trans-resveratrol that has been shown to have chemopreventive effects.

Below we have provided some of the abstracts that are included in our broad list of relevant abstracts for PRO-C.

ABSTRACT 3:
Protective effects of grape seed proanthocyanidins and selected antioxidants against TPA-induced hepatic and brain lipid peroxidation and DNA fragmentation, and peritoneal macrophage activation in mice.
Bagchi D, Garg A, Krohn RL, Bagchi M, Bagchi DJ, Balmoori J, Stohs SJ
In: Gen Pharmacol (1998 May) 30(5):771-6

1. The comparative protective abilities of a grape seed proanthocyanidin extract (GSPE) (25-100 mg/kg), vitamin C (100 mg/kg), vitamin E succinate (VES) (100 mg/kg) and beta-carotene (50 mg/kg) on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced lipid peroxidation and DNA fragmentation in the hepatic and brain tissues, as well as production of reactive oxygen species by peritoneal macrophages, were assessed. 2. Treatment of mice with GSPE (100 mg/kg), vitamin C, VES and beta-carotene decreased TPA-induced production of reactive oxygen species, as evidenced by decreases in the chemiluminescence response in peritoneal macrophages by approximately 70%, 18%, 47% and 16%, respectively, and cytochrome c reduction by approximately 65%, 15%, 37% and 19%, respectively, compared with controls. 3. GSPE, vitamin C, VES and beta-carotene decreased TPA-induced DNA fragmentation by approximately 47%, 10%, 30% and 11%, respectively, in the hepatic tissues, and 50%, 14%, 31% and 11%, respectively, in the brain tissues, at the doses that were used. Similar results were observed with respect to lipid peroxidation in hepatic mitochondria and microsomes and in brain homogenates. 4. GSPE exhibited a dose-dependent inhibition of TPA- induced lipid peroxidation and DNA fragmentation in liver and brain, as well as a dose-dependent inhibition of TPA-induced reactive oxygen species production in peritoneal macrophages. 5. GSPE and other antioxidants provided significant protection against TPA-induced oxidative damage, with GSPE providing better protection than did other antioxidants at the doses that were employed.

ABSTRACT 4:
Clinical and capillaroscopic evaluation of chronic uncomplicated venous insufficiency with procyanidins extracted from vitis vinifera
Costantini A, De Bernardi T, Gotti A
In: Minerva Cardioangiol (1999 Jan-Feb) 47(1-2):39-46

BACKGROUND: The pharmacological treatment of non-complicated chronic venous insufficiency is a current and well-debated topic. The introduction of new products with action on the venous system, improved knowledge on the physiopathology of venous insufficiency and the possibility provided by new analytical instruments, have given new impulse to the consolidation of the clinical value of phlebotonics in this indication. METHODS: In light of this, 24 patients with non-complicated chronic venous insufficiency were treated with oral administration of Oligomeric Proanthocyanidins (Pycnogenols-OPC) 100 mg/day. To evaluate the therapeutic efficacy of the treatment, an instrumental evaluation by optical probe capillaroscope was employed in addition to the traditional subjective clinical parameters: swelling, itching, heaviness and pain. The videocapillaroscope examination was performed at the lower third of the leg and the first toe. Edema in the capillaroscopic field, the number of observable capillaries and the capillary dilatation were the parameter chosen to evaluate the efficacy of treatment. All patients completed the study with no reports of adverse events during the period of observation. RESULTS: The results obtained show a positive clinical response (improved or absent symptoms) in over 80% of patients, with significant improvement of symptoms already evident after the first 10 days of treatment. The mechanism of action of the OPCs explains the rapid reduction of the swelling of the lower limbs and correlated with this are the other evaluable symptoms: heaviness and itching. Particularly striking results were observed for itching and pain which completely disappeared during the course of therapy in 80% and 53% of the patients respectively. Noteworthy is the good correlation between the clinical and instrumental data, with improvement in a total of 70% of patients. CONCLUSIONS: The results obtained in the course of this clinical experience, with evident improvement already during the first weeks of treatment, the absence of adverse events added to the benefit of a once-a-day administration, justify the use of OPC in the treatment of non-complicated chronic venous insufficiency.

ABSTRACT 5:
Polymeric procyanidin fraction from defatted grape seeds protects HepG2 cells against oxidative stress by inducing phase II enzymes via Nrf2 activation.
Younghwa Kim, Youngmin Choi, Hyeonmi Ham, Heon-Sang Jeong, Junsoo Lee
Kim, Y., Choi, Y., Ham, H. et al. Food Sci Biotechnol (2013) 22: 485. https://doi.org/10.1007/s10068-013-0105-x

Nuclear factor erythroid 2-related factor 2 (Nrf2) is an important transcription factor that regulates antioxidant response element (ARE)-driven phase II detoxification enzymes. In this study, induction of phase II enzymes via Nrf2/ARE activation in the cytoprotective effect of crude polyphenol extract (CPE), oligomeric procyanidin fraction (OPF), and polymeric procyanidin fraction (PPF) from defatted grape seeds in HepG2 cells was evaluated. Among these treatments, the treatment with PPF significantly increased Nrf2 protein expression in the nuclear fraction. Treating the samples increased heme oxygenase-1 (HO-1) and NAD(P)H:quinone oxidoreductase 1 (NQO1) protein expression in a dose-dependent manner, and PPF significantly increased the levels of phase II enzymes. Cellular generation of reactive oxygen species (ROS) were effectively reduced by PPF. These results suggest that pretreatment with PPF shows a cytoprotective effect by inhibiting ROS production and inducing HO-1 and NQO1 expression via Nrf2 activation in HepG2 cells.

GREEN TEA EXTRACT

Green tea extract is obtained from the unfermented leaves of Camellia sinensis for which numerous biological activities have been reported including: antimutagenic, antibacterial, hypocholesterolemic, antioxidant, and protective against tumorigenesis. Below we have selected a few of the many abstracts we have on file showing the benefit of green tea extract.

Green tea antioxidant polyphenols catechins

Green tea leaves are high in antioxidant polyphenols and catechins.

ABSTRACT 6:
Enhancement of antioxidant and phase II enzymes by oral feeding of green tea polyphenols in drinking water to SKH-1 hairless mice: possible role in cancer chemoprevention.
Khan SG, Katiyar SK, Agarwal R, Mukhtar H
In: Cancer Res (1992 Jul 15) 52(14):4050-2

Following the oral feeding of a polyphenolic fraction isolated from green tea (GTP) in drinking water, an increase in the activities of antioxidant and phase II enzymes in skin, small bowel, liver, and lung of female SKH-1 hairless mice was observed. GTP feeding (0.2%, w/v) to mice for 30 days significantly increased the activities of glutathione peroxidase, catalase, and quinone reductase in small bowel, liver, and lungs, and glutathione S-transferase in small bowel and liver. GTP feeding to mice also resulted in considerable enhancement of glutathione reductase activity in liver. In general, the increase in antioxidant and phase II enzyme activities was more pronounced in lung and small bowel as compared to liver and skin. The significance of these results can be implicated in relation to the cancer chemopreventive effects of GTP against the induction of tumors in various target organs.

ABSTRACT 7:
INHIBITORY EFFECT OF SIX GREEN TEA CATECHINS AND CAFFEINE ON THE GROWTH OF FOUR SELECTED HUMAN TUMOR CELL LINES.
In: Anticancer Drugs (1996 Jun) 7(4):461-8
Institutional address: Department of Pharmacology and Toxicology College of Pharmacy University of Arizona Tucson 85721 USA.

Green tea is an aqueous infusion of dried unfermented leaves of Camellia sinensis (family Theaceae) from which numerous biological activities have been reported including antimutagenic, antibacterial, hypocholesterolemic, antioxidant, antitumor and cancer preventive activities. From the aqueous-alcoholic extract of green tea leaves, six compounds (+)-gallocatechin (GC), (-)-epicatechin (EC), (-)- epigallocatechin (EGC), (-)-epicatechin gallate (ECG), (-)- epigallocatechin gallate (EGCG) and caffeine, were isolated and purified. Together with (+)-catechin, these compounds were tested against each of four human tumor cells lines (MCF-7 breast carcinoma, HT-29 colon carcinoma, A-427 lung carcinoma and UACC-375 melanoma). The three most potent green tea components against all four tumor cell lines were EGCG, GC and EGC. EGCG was the most potent of the seven green tea components against three out of the four cell lines (i.e. MCF-7 breast cancer, HT-29 colon cancer and UACC-375 melanoma). On the basis of these extensive in vitro studies, it would be of considerable interest to evaluate all three of these components in comparative preclinical in vivo animal tumor model systems before final decisions are made concerning which of these potential chemopreventive drugs should be taken into broad clinical trials.

GLUTATHIONE AND N-ACETYL-L-CYSTEINE (NAC)

Glutathione and NAC (a major precursor of glutathione) both provide important protection against toxins and free radicals, and can strengthen the immune system. Glutathione is considered to be one of the most important protective substances in the human body with almost 60% of liver detoxification accounted for by this key substance. In addition, glutathione is one of the most potent anti-viral substances known.

Some research has indicated that glutathione may not be able to enter easily into certain types of cells, but NAC is able to enter these cells and be converted into glutathione once inside the cell. Thus, the combination of glutathione and NAC appear to be more potent than either alone.

Below we provide some of the key abstracts we have on file regarding NAC and glutathione.

ABSTRACT 8
GSH rescue by N-acetylcysteine.
Ruffmann R Wendel A
In: Klin Wochenschr (1991 Nov 15) 69(18):857-62

Reduced glutathione (GSH) is the main intracellular low molecular weight thiol. GSH acts as a nucleophilic scavenger and as an enzyme-catalyzed antioxidant in the event of electrophilic/oxidative tissue injury. Therefore, GSH has a major role as a protector of biological structures and functions. GSH depletion has been recognized as a hazardous condition during paracetamol intoxication. Conversely, GSH rescue, meaning recovery of the protective potential of GSH by early administration of N-acetylcysteine (NAC), has been found to be life-saving. Lack of GSH and electrophilic/oxidative injury have been identified among the causes of the adult respiratory distress syndrome (ARDS), idiopathic pulmonary fibrosis (IPF), and the acquired immunodeficiency syndrome (AIDS). Experimental and early clinical data (in ARDS) point to the role of NAC in the treatment of these conditions. Recently, orally given NAC has been shown to enhance the levels of GSH in the liver, in plasma, and notably in the bronchoalveolar lavage fluid. Rescue of GSH through NAC needs to be appreciated as an independent treatment modality for an array of different disease, all of which have one feature in common: pathogenetically relevant loss of GSH.

ABSTRACT 9
Cysteine and glutathione concentrations in plasma and bronchoalveolar lavage fluid after treatment with N-acetylcysteine.
Bridgeman MM Marsden M MacNee W Flenley DC Ryle AP
In: Thorax (1991 Jan) 46(1):39-42

N-acetylcysteine (600 mg/day) was given to patients by mouth for five days before bronchoscopy and bronchoalveolar lavage to determine whether N-acetylcysteine could increase the concentrations of the antioxidant reduced glutathione in plasma and bronchoalveolar lavage fluid. Bronchoalveolar lavage was performed 1-3 hours (group 2, n = 9) and 16-20 hours (group 3, n = 10) after the last dose of N-acetylcysteine and the values were compared with those in a control group receiving no N-acetylcysteine (group 1, n = 8). N-Acetylcysteine was not detected in plasma or lavage fluid. Plasma concentrations of cysteine, the main metabolite of N-acetylcysteine and a precursor of reduced glutathione, were greater in the groups receiving treatment (groups 2 and 3) than in group 1. Cysteine concentrations in lavage fluid were similar in the three groups. Concentrations of reduced glutathione were greater in both plasma and lavage fluid in group 2 than in group 1. These data suggest that N-acetylcysteine given by mouth is rapidly deacetylated to cysteine, with resulting increases in the concentrations of cysteine in plasma and of reduced glutathione in plasma and the airways, which thus temporarily increase the antioxidant capacity of the lung.

R-LIPOIC ACID / ALPHA-LIPOIC ACID

R-Lipoic Acid is normally made at low levels in the human body, where it functions primarily as an important metabolic nutrient in the conversion of pyruvic acid into acetyl coenzyme A. As such, it plays a crucial role in the metabolism of both fats and carbohydrates into energy. In addition, r-lipoic acid functions as an extremely powerful antioxidant capable of trapping many different types of free radicals in the body.

Because it is both water and fat soluble, lipoic acid is able to operate in a broader range of body tissues than most other antioxidants. Its small size allows lipoic acid to enter areas of the body not easily accessible to many other substances; this allows lipoic acid, for example, to enter the cell nucleus and prevent free-radical damage to DNA.

Because it is such a powerful antioxidant and can easily function as such in both a reduced and oxidized state, lipoic acid is able to protect other important antioxidants such as glutathione, Vitamin E, and Vitamin C. R-lipoic acid is also able to chelate heavy metals such as lead, cadmium, mercury, free iron, and free copper out of the body.

Below we provide relevant scientific abstracts from our database regarding R-Lipoic acid.

ABSTRACT 10:
Alpha-Lipoic acid as a biological antioxidant.
Packer L Witt EH Tritschler HJ
In: Free Radic Biol Med (1995 Aug) 19(2):227-50

alpha-Lipoic acid, which plays an essential role in mitochondrial dehydrogenase reactions, has recently gained considerable attention as an antioxidant. Lipoate, or its reduced form, dihydrolipoate, reacts with reactive oxygen species such as superoxide radicals, hydroxyl radicals, hypochlorous acid, peroxyl radicals, and singlet oxygen. It also protects membranes by interacting with vitamin C and glutathione, which may in turn recycle vitamin E. In addition to its antioxidant activities, dihydrolipoate may exert prooxidant actions through reduction of iron. alpha-Lipoic acid administration has been shown to be beneficial in a number of oxidative stress models such as ischemia-reperfusion injury, diabetes (both alpha-lipoic acid and dihydrolipoic acid exhibit hydrophobic binding to proteins such as albumin, which can prevent glycation reactions), cataract formation, HIV activation, neurodegeneration, and radiation injury. Furthermore, lipoate can function as a redox regulator of proteins such as myoglobin, prolactin, thioredoxin and NF-kappa B transcription factor. We review the properties of lipoate in terms of (1) reactions with reactive oxygen species; (2) interactions with other antioxidants; (3) beneficial effects in oxidative stress models or clinical conditions.

ABSTRACT 11:
Regeneration of glutathione by α-lipoic acid via Nrf2/ARE signaling pathway alleviates cadmium-induced HepG2 cell toxicity.
Zhang J, Zhou X, Wu W, Wang J, Xie H, Wu Z.
In: Environ Toxicol Pharmacol. 2017 Apr;51:30-37. doi: 10.1016/j.etap.2017.02.022. Epub 2017 Feb 27.

Alpha-lipoic acid (α-LA) is an important antioxidant that is capable of regenerating other antioxidants, such as glutathione (GSH). However, the underlying molecular mechanism by which α-LA regenerates GSH remains poorly understood. The current study aimed to investigate whether α-LA regenerates GSH by activation of Nrf2 to alleviate cadmium-induced cytotoxicity in HepG2 cells. In the present study, we found that cadmium induced cell death by depletion of GSH through inactivation of Nrf2. Addition of α-LA to cadmium-treated cells reactivated Nrf2 and regenerated GSH through elevating the Nrf2-downstream genes γ-glutamate-cysteine ligase (γ-GCL) and GR, both of which are key enzymes for GSH synthesis. However, blocking Nrf2 with brusatol in the cells co-treated with α-LA and cadmium reduced the mRNA and the protein levels of γ-GCL and GR, thus suppressed GSH regeneration by α-LA. Our results indicated that α-LA activated Nrf2 signaling pathway, which upregulated the transcription of the enzymes for GSH synthesis and therefore GSH contents to alleviate cadmium-induced cytotoxicity in HepG2 cells.

SELENIUM

Selenium has been shown by clinical research to be a key mineral in the body’s defenses against free radicals and has been shown to be a major factor in reducing the symptoms of HIV infections and in the prevention of tumors. Selenium is used in conjunction with glutathione to form the powerful enzyme glutathione peroxidase that is responsible for detoxification of peroxides formed during the process of aerobic metabolism in humans and other animals.

ABSTRACT 12
Serum selenium concentrations in rheumatoid arthritis.
In: Ann Rheum Dis (1991 Jun) 50(6):376-8

O’Dell JR, Lemley-Gillespie S, Palmer WR, Weaver AL, Moore GF, Klassen LW

Selenium is a trace element and an essential part of the enzyme glutathione peroxidase, which protects cells from oxidative damage. Selenium has been shown to have antiproliferative, anti-inflammatory, antiviral, and immune altering effects. Serum selenium concentrations in 101 patients with seropositive rheumatoid arthritis were found to be significantly lower than those in 29 normal, healthy controls (mean (SD) 148 (42) v 160 (25) micrograms/l) and also lower than those in eight patients with fibrositis (148 (42) v 166 (25) micrograms/l). It is speculated that serum selenium concentrations may modulate the effect of viral or other infections in subjects with the appropriate genetic background and in this way enhance the development or progression of rheumatoid arthritis.

ABSTRACT 13
Studies on selenium in top athletes.
Dragan I, Ploesteanu E, Cristea E, Mohora M, Dinu V, Troescu VS
In: Physiologie (1988 Oct-Dec) 25(4):187-90

The authors performed a controlled trial in 18 top athletes (9 weight lifters and 9 rowers, girls) in order to make evident some chronic and acute effects (antioxidant) of selenium. Nonprotein–SH (essential glutathione), lipid peroxides (MDA-malondialdehyde), glucose-6-phosphate dehydrogenases (G-6-PDH) and fructose-1,6- diphosphate aldolase in serum, have been recorded initially on basal conditions, after 3 weeks of treatment (100 micrograms/day selenium or placebo) and again after 3 weeks of treatment, also on basal conditions, when crossing over the groups (between a free interval of 10 days). In another trial we registered these parameters on basal conditions and after two hours of hard training accompanied by a per oral administration of 150 micrograms selenium (respectively placebo). The results show significant changes under selenium treatment of the peroxides, G-6-PDH and light changes, not significant of the nonprotein–SH, changes which could suggest an antioxidant effect of this element.

VITAMINS B2 and B6 IN COENZYME FORMS

Vitamin B2 as coenzyme riboflavin-5-phosphate is a key vitamin that supports the regeneration of glutathione (via glutathione reductase). Vitamin B6 as coenzyme pyridoxal-5-phosphate is a key vitamin that supports the ability of glutathione to combine with toxic substances (via glutathione transferase) in the process of eliminating them from the body. They are especially effective in their coenzyme forms which allows them to be directly utilized by the body starting in the intestinal tract.

MAGNESIUM, CALCIUM, AND ZINC

Magnesium, zinc, and calcium synergistically work with (and enhance the effects of) the other ingredients in PRO-C. Minerals are especially needed as active components of enzymes that drive metabolic activity. For example, magnesium is required in the functioning of more than 325 types of enzymes.

PRO-C™ SUPER ANTIOXIDANT FORMULA BENEFITS

HIGHLY EFFECTIVE VITAMIN C FORMULA PLUS ANTIOXIDANTS. A complete vitamin C formula, a powerful antioxidant Formula, and Nrf2 activator combined in a single advanced supplement!

POWERFUL, SYNERGISTIC FREE-RADICAL QUENCHING FORMULA. PRO-C™ components work together to quench free radicals in your body. Vitamin C enables grape seed extract to function more effectively, and conversely grape seed extract potentiates vitamin C. Green tea extract boosts ORAC (Oxygen Radical Absorbance Capacity) value.

PROVIDES SIGNIFICANT AMOUNTS OF POWERFUL NRF2 ACTIVATORS (from Grape Extract, Green Tea Extract, NAC, and R-Lipoic Acid) that stimulate the production of the body’s own protective antioxidants including superoxide dismutase, catalase, glutathione peroxidase, and heme oxygenase.

SUPERIOR, BUFFERED (NON-ACIDIC) FORM OF VITAMIN C. Mineral Ascorbates never acidify your body, keeping you pH balanced. Staying alkaline is an important element in maintaining a healthy body.

RAPID ASSIMILATION. Capsule form ensures rapid uptake and assimilation in the body. You may also empty capsule contents into water, food, or directly Into mouth, if desired. Good, mildly tart taste!

COMPOSITION OF PRO-C™ SUPER ANTIOXIDANT FORMULA

One (1) vegetarian capsule of PRO-C provides the following percentages of the Daily Value:

NUTRIENT AMOUNT % Daily Value
Vitamin C (from mineral ascorbates) 500 mg 833%
BioVin® Grape Extract 30 mg *
Green Tea Extract 30 mg *
Calcium (from calcium ascorbate) 23 mg 2.3%
Magnesium (from magnesium ascorbate) 23 mg 5.7%
L-Glutathione (reduced) 20 mg *
N-Acetyl-L-Cysteine (NAC) 15 mg *
R-Lipoic Acid 5 mg *
Zinc (from zinc ascorbate) 2 mg 13%
Vitamin B2 (from riboflavin-5′-phosphate) 1 mg 118%
Vitamin B6 (from pyridoxal-5′-phosphate) 1 mg 50%
Selenium (from l-selenomethionine) 10 mcg *

* No established Daily Value

DIRECTIONS: As a dietary supplement take 1–3 capsules or more daily in divided doses (i.e., spread out over the day), or as recommended by a health care professional. It initially may be useful to take up to 6 capsules per day in divided doses for one week. The contents of the capsule may be emptied into juice or food, as needed.

INGREDIENTS: PRO-C™ SUPER ANTIOXIDANT FORMULA contains only the highest-quality USP grade magnesium ascorbate, USP grade calcium ascorbate, BioVin® grape extract (greater than 75% polyphenols, 93% OPC, greater than 3.5% anthocyanidins from grape pulp, skins, and seeds, and a small amount of trans resveratrol), green tea extract (95% min. polyphenols and 45% min. EGCG), l-glutathione (reduced), USP grade n-acetyl-l-cysteine, USP grade zinc ascorbate, r-(+)-lipoic acid, riboflavin-5′-phosphate, pyridoxal-5′-phosphate, l-selenomethionine, the smallest amounts of microcrystalline cellulose and silica in a vegetarian capsule.

PRO-C™ does not contain wheat, rye, oats, corn antigen, barley, gluten, soy, egg, dairy, yeast, sugar, sulfates, phosphates (other than coenzyme forms), fats, chlorides, GMOs, wax, preservatives, colorings, or artificial flavorings.

Click here to order PRO-C™.

SOURCES & RESOURCES

BOOKS

The Antioxidant Miracle. Lester Packer, PhD, and Carol Coleman. New York: John Wiley and Sons, 1999.

How to Live Longer and Feel Better. Dr. Linus Pauling. Corvallis, OR: Oregon State University Press, 2006.

ARTICLES

Review of Scientific Research on Oligomeric Proanthocyanidins (OPC)” (rev. 2017) by Hank Liers, PhD

“Vitamin C – An Amazing Nutrient” by Hank Liers, PhD

PRO-C™ and Ultimate Protector™ – Comparison by Hank Liers, PhD

“Antioxidant Cocktail Update: Part 1: The Take Home Message is to Use Antioxidant Supplements”
(An interview of Dr. Lester Packer by Richard A. Passwater, PhD, Whole Foods Magazine 1999)

ABSTRACTS

PRO-C™ / Vitamin C Abstracts

Catechin Abstracts

N-Acetyl-L-Cysteine (NAC) Abstracts

Lipoic Acid Abstracts

WEBSITES

Orthomolecular.org
(Therapeutic Nutrition Based Upon Biochemical Individuality)

PRODUCTS

PRO-C™Super Antioxidant Formula

Ultimate Protector™Nrf2 Activator Formula

OPC-C™

HPDI Vitamin C Products

2

THE NEED FOR IODINE SUPPLEMENTATION

Dr. Hank Liers PhD iodine supplementationFred Liers PhD iodine supplementationThe Orthomolecular Medicine News Service (OMNS) published on June 12 “The Need for Iodine Supplementation.” We believe strongly in the need for iodine supplementation, especially given the fact that more than 90% of the US population is iodine deficient. For this reason we make available both Nascent Iodine and Lugol’s Iodine Solution 2 to our customers.

We present the full OMNS article (below), as a source of valuable information to our resellers and Creating Health Naturally readers. The factors contributing to massive-scale iodine deficiency remain virtually unchanged over decades. This has led to a greater need for educating health professionals and individuals about the critical importance of iodine supplementation.

Another useful article discussing the benefits of iodine supplementation was published August 2 by Dr. Mark Sircus, OMD: “Iodine, Thyroid and Low Body Temperature.” ~

The Need for Iodine Supplementation

by Wojciech Rychlik, PhD

(OMNS, June 12, 2017) Feeling tired, having low energy or depression, gaining weight, memory problems, having dry skin, dry mouth, or immune system issues? There is good chance your body needs iodine supplementation. Why iodine? Because this essential to human health element has been singled out as dangerous, for several obscure reasons, and it has been gradually eliminated from our diet, and even worse, replaced by its antagonist, bromine. This trend has been termed, iodophobia (1). It is a cause of widely occurring hypothyroidism in many developed countries.

Iodine: How Much?

Iodine deficiency is associated with (2, 3, 4):

  • Fibrocystic breast disease leading to breast cancer and stomach cancer
  • Goiter (enlarged thyroid)
  • Mental issues from reduced alertness, lowered IQ, autism to cretinism, lack of iodine for the fetus leads to cretinism, and in milder cases to autism and ADHD
  • Slow metabolism, leading to tiredness, sluggishness, fatigue, apathy, depression, and insomnia
  • Inability to produce saliva, dry skin, and lack of sweating
  • Lack of optimal detoxification, especially of bromides, fluorides, and heavy metals
  • Sensitivity to temperature changes, and cold hands and feet
  • Muscle pain, fibrosis, and fibromyalgia
  • Erectile dysfunction, infertility and miscarriages, and low sex drive
  • Overweight
  • High blood pressure, and increased incidence of heart attacks and strokes

The Food and Agriculture Organization (FAO) of the United Nations has published probable safe upper limits for dietary intake of iodine (5). They range from 150 micrograms (mcg) per kilogram (kg) per day in newborn infants to 30mcg/kg/day in adults. That is 2 milligrams (2,000 micrograms) daily for a 146-pound adult. The safe upper limit is higher during pregnancy and lactation (40 mcg/kg/day).

Treatments for Hypothyroidism

The simplest method to deal with an underactive thyroid is proper supplementation with iodine, called orthoiodosupplementation. If the thyroid is damaged, then supplementation with thyroid hormones, thyroxine (T4) and triiodothyronine (T3, the main biologically active hormone) may be necessary. Supplementation (6). with these hormones should be done under close supervision of a medical professional. However, supplementation with inorganic iodine is generally much safer, as the body “knows” how much T4 and T3 need to make. There are also drugs that change physiology of iodine metabolism, but this subject is beyond the scope of this article. Pharmaceutical companies pressure doctors to avoid inexpensive orthoiodosupplementation, so you won’t likely get a prescription for inexpensive Lugol’s solution from a mainstream practitioner.

One caveat to supplementation with iodine is the autoimmune illness called Hashimoto’s disease, or chronic lymphocytic thyroiditis, which is one of the potential causes of hypothyroidism. Unfortunately, when hypothyroidism is diagnosed, the possibility that Hashimoto’s disease underlies this condition has not always been properly tested. Therefore, Hashimoto’s disease has often been misdiagnosed. Doctors usually treat this condition with hormone replacement therapy, and some believe that excessive iodine intake may trigger it in susceptible people (7). Always ask your doctor if iodine supplements are right for you.

History of Iodine Usage and “Iodophobia”

This subject has been covered in detail by Dr. Guy E. Abraham (8,9,10). The iodine element was discovered in 1811 by B. Courtois. In 1850–1853 A. Chatin noted that goiter and cretinism are rare in geological zones rich in iodine and frequent where iodine is in short supply, and that goiter can be prevented by iodine supplementation. In 1895 E. Baumann proposed that iodine is the active element in the thyroid gland.

By the time Bauman identified large concentrations of iodine in the thyroid gland in 1895, pharmaceutical and apothecary preparations containing iodine, excluding thyroid extracts, were widely used as a panacea.

To quote Kelley: (11) “The variety of diseases for which iodine was prescribed in the early years is astonishing – paralysis, chorea, scrofula, lacrimal fistula, deafness, distortions of the spine, hip-joint disease, syphilis, acute inflammation, gout, gangrene, dropsy, carbuncles, whitlow, chilblains, burns, scalds, lupus, croup, catarrh, asthma, ulcers, and bronchitis – to mention only a few. Indeed, tincture of iodine, iodoform, or one of the iodides, was applied to almost every case that resisted the ordinary routine of practice; and between 1820 and 1840 there appeared a remarkable series of essays and monographs testifying to the extraordinary benefits to be achieved by this new and potent remedy.”

Unfortunately, these monographs have virtually disappeared from US medical libraries. In the mid-1800s, iodine treatments of some diseases called for ingestion of gram (1,000 mg) amounts per day. However, most treatments were from 5 to 50 mg daily. The recommended daily amount of iodine by Dr. G. E. Abraham is 0.1-0.3 ml Lugol containing 12.5-37.5 mg elemental iodine. This is the amount of iodine needed for whole body sufficiency, based on a recently reported iodine/iodide-loading test (12). Thyroid gland sufficiency for iodide is achieved with a lower dose.

Lugol's iodine supplementation

The first iodophobic authority emerged in early 1900s. Prof. T. Kochler reported that he suffered from overactive thyroid following ingestion of iodide (just a single individual case, not a statistical research study!) Despite this, the number of applications grew. In an International Index published in 1956, and devoted exclusively to iodine pharmaceuticals, no less than 1,700 approved iodine-containing products were listed. In 1948 Wolff and Chaikoff published that a serum inorganic iodide level at a concentration of 1 µM blocks (one micromolar) the synthesis of thyroid hormones, resulting in hypothyroidism and goiter in rats. But this conclusion was erroneous as they even did not measure thyroid hormones in the rats studied, and of course, hypothyroidism and goiter were not observed in those rats. Many organic forms of iodinated drugs were quite poisonous. Unfortunately, medical establishment did not make a distinction between organic and inorganic forms of iodine, and iodophobia became more popular.

Decades ago, iodine was added to bread so that one slice contained 150 mcg of iodine (the current recommended daily allowance). In the 1980s, bromine replaced iodine in bread. Since bromide is an antagonist to iodine (it is goitrogenic), it worsened iodine deficiency in the US. Moreover, a big push to remove salt from our diet (the only grocery item still supplemented with iodine) exacerbated the problem. The only developed nation that resisted iodophobia is Japan, statistically the healthiest and longest living nation on the planet. Their average daily consumption of iodine is around 5 mg, with various reports ranging from 1 mg to 18 mg. In a study of reported daily iodine intake versus total number of clinical symptoms, an intake of approximately 1 mg per day correlated with the lowest number of reported symptoms, that is, the highest level of health (13). Recent popularization of bromides in our food supplies likely increased this amount.

According to Dr. Abraham, (14) “proper amounts of iodine in the food supply should be considered one of a nation’s greatest assets. Removing iodine from the food supply is a major mistake. Supplying a daily intake of iodine sufficient for the whole body (100-400 times the RDA) gives protection against goitrogens and radioactive iodine/iodide fallout; improves immune functions, resulting in an adequate defense system against infection; decreases singlet oxygen formation which is the major cause of oxidative damage to DNA and macromolecules, resulting in an anticarcinogenic effect in every organ; results in a detoxifying effect by increasing urinary excretion of the toxic metals lead, mercury, cadmium, and aluminum, as well as the goitrogens fluoride and bromide; normalizes hormone receptor functions resulting in improved response to thyroid hormones both endogenous and exogenous; and results in better control of blood sugar in diabetic patients; stabilizes cardiac rhythm, obviating the need for the toxic sustained release form of iodine, amiodarone; and normalizes blood pressure without medication in hypertensive patients. Iodine deficiency is the major cause of cognitive impairment, worldwide.”

The Iodine-Cancer Connection

The body requires iodine to metabolize both omega-3 and omega-6 fatty acids. A substance called delta-iodolactone, a derivative of arachidonic acid, which is produced in the thyroid gland and breast tissue, prostate, colon, and the nervous system, is a regulator of a process called cellular apoptosis (“cell death”). Ascorbic acid is required to stimulate intracellular hydrogen peroxide synthesis that, in turn, provides the energy to make iodine free radicals necessary for this reaction. When the level of delta-iodolactone is high enough, the process of apoptosis can then kill cancer cells. (15)

Unfortunately, the recommended daily allowance (RDA) for iodine — about 150 mcg per day — will not allow delta-iodolactone to be efficiently formed in the thyroid gland. The thyroid requires higher iodine concentrations to efficiently produce it. Researchers have found that 100 times the RDA amount of iodine is optimal to produce delta-iodolactone. That equates to taking about 15 mg of iodine per day (15,16). These findings are important because they imply that there are some biochemical reactions that require much larger amounts of iodine than the current RDA. The mechanism by which delta-iodolactone induces cell death may be an important pathway for curing some types of cancer.

Forms of Iodine

Inorganic iodine exists in 6 oxidative states, from -1 to +7. The most reduced form (with most electrons) is iodide (I); an example is potassium iodide. The diatomic form of elemental iodine I2, has no electrical charge. Monoatomic iodine also has no electrical charge, but is unstable and highly reactive (free radical, labeled as an I with a dot, I* ). It can be produced by exposing I2 to ultraviolet light. Electric and magnetic fields won’t do it, as is sometimes incorrectly suggested. More oxidized forms of iodine are: hypoiodite (I+1), iodite (I+3), iodate (I+5), and periodate (I+7). The body’s metabolism may convert (reduce) these forms to biochemically available iodide, but at the cost of depleting its antioxidants. All forms of positively charged iodine are relatively poisonous, with established lethal doses (LD50) in the range of 35 to 2100 mg/kg. Elemental iodine (I2) and iodides (I) are non-poisonous. However, a bad “antiseptic” non-culinary taste of iodine (I2) suggests to our senses that this is not so good choice for supplementation.Nascent iodine supplementation

Despite that adverse taste, almost all the research on iodine supplementation has been done using Lugol’s Solution (17). The original solution is called 5% Lugol’s Iodine, but in reality it consists of 12.5% iodide/iodine or (I/[I3]) ions. Two drops of Lugol’s Solution (0.1 ml) contain 12.5 mg iodine/iodide mix. Iodine tablets that are a solid form of Lugol’s solution, were created to mask the taste and make the doses more precise for dietary supplementation.

I should mention a few points about Edgar Cayce’s atomidine. This famous visionary wrote several articles about the best form of iodine supplement (18). Some claim that this was iodine trichloride, but that cannot be true as this compound is toxic by ingestion and damaging to mucous membranes. It decomposes to ICl and poisonous gas Cl2 at 77 degrees C and also in water at room temperature (19). Most likely Cayce’s atomidine was simply a 1% iodine solution (I2) in 95% ethanol. I am surprised that there are educated people, even medical doctors who claim that “elemental monoatomic iodine” preparations (Atomidine, Nascent Iodine etc.) are the best forms of iodine supplements. May be it has something to do with efficient marketing? Elemental Iodine (I2) is soluble in glycerin. Replacement of ethanol with glycerol indeed makes these supplements more consumption-friendly, so they are sold by some vendors as superior products to Cayce’s ethanol-formulated one. Personally, I think glycerol-based I2 supplements are inferior to iodides; however, they are excellent antiseptics.

To defend the validity of Cayce’s vision, in thyroid, I ion and amino acid tyrosine react through a short intermediate step by forming monoatomic I* free radical (selenium and hydrogen peroxide are involved) to make monoiodotyrosine. Diiodotyrosine is formed analogical way, and finally, two of these molecules combine to produce thyroxine. All those steps are carried by the enzyme thyroid peroxidase, which is normally attached to the protein thyroglobulin. So, yes, monoatomic iodine I* exists in human bodies, and it directly reacts with tyrosine, but no, it wouldn’t be healthy to consume iodine free radicals as their high reactivity would prevent safe transport throughout the body.

In the mid-1930s the thyroid hormone thyroxine became available on the market. This was a blessing for people who had damaged their thyroid. Unfortunately, doctors started to prescribe this hormone to just about anybody with hypothyroidism, thinking that they can control better thyroid hormone levels than our bodies can. And, the “iodine is iodine, no matter what form” mentality became a dangerous trend, because most medical professionals do not fully appreciate the difference between the raw nutrient (iodine) and its product (hormone).

The pharmaceutical industry came up with lots of organic forms of iodine (NB: organic, meaning that iodine is bound to a carbon-atom-containing molecule and NOT meaning it’s grown in a pesticide-free environment), all relatively toxic and certainly not to be used without strict medical supervision. Only inorganic forms of iodine, I and I2, are safe for supplementation (20,21). Further, high doses of these supplements should still be supervised by your doctor.

Iodine Uses

Iodine plays critical role in human metabolism. Many researchers believe the RDA value of 150 mcg for iodine is too low, especially when this element is commonly substituted with competing element bromine. Therefore, the main use of iodine in dietary supplementation is to enable optimal thyroid function. There are a number of medical conditions where iodine is either essential or helpful. For best results, iodine/iodide should be supplemented with selenium, magnesium, copper (there is usually enough of it in tap water as copper is widely used in plumbing), vitamin B2 (riboflavin) and B3 (niacin). Ask your doctor before taking any iodine supplements, especially if you are on medications.

Elemental iodine (I2) is antibacterial and antifungal, so iodine or iodine/iodide solutions are commonly used topically to sterilize wounds, or internally to fight infections, such as vaginitis and sore throat, and also to sanitize drinking water. Because iodine is antibacterial, drinking it may cause friendly bacterial flora to suffer and result in diarrhea and stomach cramps (the same applies to Lugol’s solution, but to a lesser extent as it contains iodides as well).

Ingestion of iodides prevents the incorporation of destructive radioactive iodine into the body (mainly by the thyroid) in case of nuclear accidents. It also may help flushing already incorporated radioactive iodine from the thyroid, although too much iodine inhibits secretion of T4/T3 from the gland.

Common-Sense Cautions

Overdosing any of the iodine supplements can lead to swollen salivary glands, metallic aftertaste and skin rash and itching (that are usually due to rapid process of detoxification from heavy metals fluorides and bromides), faster heartbeat or palpitations and diarrhea. When supplementation is stopped, these symptoms will usually disappear quickly, often within one day. Iodine stabilizes thyroid hormone production, so it is an adaptogen, but in rare cases, such as acquired allergy to iodine (Hashimoto’s disease), it may actually misbalance it. In some cases, iodine supplementation can cause hypothyroidism, so it’s important to get checked by your doctor to make sure that your thyroid function is not worsened by supplementation. Some authors advising caution are Alan Christianson (22), Jeffrey Dach, (23) and Alan Gaby (24). Testing of levels of thyroid hormones along with testing and supplementation of mineral nutrients such as selenium, zinc, copper, magnesium calcium, and other trace minerals may prevent problems in cases where high doses of iodine/iodide might tend to cause Hashimoto’s disease. (23)

Inorganic Iodine Availability

The most common form of iodine supplement is Lugol’s solution (17). The original solution contains 5% of iodine and 10% iodide. Solid pill forms of Lugol’s solution are sold under several brand names. Potassium iodide (KI), my favorite iodine supplement, is available as tablets as well. Various products with kelp or other seaweed extracts contain iodides as well. Check the label when you buy as some of them are very diluted.

It is difficult to find inexpensive elemental iodine (I2) solution in alcohol. You can buy iodine crystals online and make the proper solution by yourself very easily (using either alcohol or glycerol). The monoatomic iodine concept is simply a marketing gimmick that has been created to inflate the price several fold. Note that if the monoatomic claims were really true, few would really want to drink free radicals, the only monoatomic form that exists. Iodine free radicals are not transported freely in our bodies because they are too reactive. Elemental iodine preparations, including iodine dissolved in glycerol, may be helpful products for external antiseptic use rather than a supplement.

Another form of iodine supplement includes a mixture of algae and thyroid extract in glycerin, water and ethanol. This is likely not harmful because it contains T3 and T4 only in very small amounts, and the recommended serving size is also small. Other complex formulae that contain elemental iodine are a useful antiseptic, but not a good supplement. Iodine trichloride should be avoided as a supplement because it is too toxic.(19)

Summary

The established RDA allowance for iodine (150 mcg/day) is inadequate for many individuals. In order to maintain optimum health, adults need 2-5 mg of iodide daily. Actually, this is in line with the upper safe limit of dietary intake of iodine established by FAO (30 mcg/kg/day). In case of a dysfunctional thyroid or other illnesses, such as fibrocystic breast disease or cancer, 15-50 mg daily may be needed. Ask your doctor about the alternatives to hormone therapy or taking iodine-containing organic drugs, because inexpensive orthoiodosupplementation would usually not be his/her first choice.

The best and safest form of iodine supplementation for a healthy adult is iodide. Iodides are naturally produced in larger quantities by various seaweeds.

Please consult your doctor about iodine supplementation, as in your particular case it may be contraindicated.

References:

1. Abraham GE. The History of Iodine in Medicine Part III: Thyroid Fixation and Medical Iodophobia. http://optimox.com/pics/Iodine/IOD-16/PUB_16.htm

2. Dommisse J. MD Best Kept Secret (2009) http://www.westonaprice.org/modern-diseases/best-kept-secret/#sthash.vdrKPaJw.dpuf

3. http://theiodineproject.webs.com/addadhdautism.htm

4. Hamza RT1, Hewedi DH, Sallam MT. (2013) Iodine deficiency in Egyptian autistic children and their mothers: relation to disease severity. Arch Med Res. 44(7):555-61. http://www.ncbi.nlm.nih.gov/pubmed/24120386

5. http://www.fao.org/docrep/004/y2809e/y2809e0i.htm

6. Abraham GE. The Concept of Orthoiodosupplementation and Its Clinical Implications. https://www.optimox.com/pics/Iodine/IOD-06/IOD_06.htm

7. http://www.webmd.com/women/hashimotos-thyroiditis-symptoms-causes-treatments#1

8. Abraham GE. The History of Iodine in Medicine Part I: From Discovery to Essentiality. http://optimox.com/pics/Iodine/IOD-14/PUB_14.htm

9. Abraham GE. The historical background of the Iodine Project. http://www.optimox.com/pics/Iodine/IOD-08/IOD_08.htm

10. Abraham GE. The History of Iodine in Medicine Part II: The Search for and the Discovery of Thyroid Hormones. http://optimox.com/pics/Iodine/IOD-15/PUB_15.htm

11. Kelly FC. “Iodine in medicine and pharmacy since its discovery , 1811-1961.” Proc R Soc Med, 1961; 54:831-836. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1869599/

12. Abraham GE. “The safe and effective implementation of orthoiodosupplementation in medical practice.” The Original Internist, 2004; 11(1):17-36. http://www.hakalalabs.com/Research/Abraham_OI_Mar04.pdf

13. Fallon Morell S. The Great Iodine Debate (2009) The WestonA. Price Foundation, http://www.westonaprice.org/modern-diseases/the-great-iodine-debate/

14. Abraham GE. The Wolff-Chaikoff Effect: Crying Wolf? https://www.optimox.com/pics/Iodine/IOD-04/IOD_04.html

15. Brownstein D. The Cancer-Iodine Connection, (2015) http://www.newsmax.com/Health/Dr-Brownstein/iodine-cancer-cell-death-fish-oil/2015/06/10/id/649877/

16. 6-Iodolactone, key mediator of antitumoral properties of iodine, M. Nava-Villalba, C. Aceves, (2014) Prostaglandins & Other Lipid Mediators 112, 27-33. https://www.researchgate.net/publication/263856609_6-Iodolactone_key_mediator_of_antitumoral_properties_of_iodine

17. Bacteriological Analytical Manual, R40 Lugol’s Iodine Solution (2001), http://www.fda.gov/Food/FoodScienceResearch/LaboratoryMethods/ucm062245.htm

18. Review of Atomidine, International Wellness Directory, http://www.mnwelldir.org/docs/reviews/atomidine.htm

19. Material safety data sheet, http://www.mnwelldir.org/docs/history/Iodine_Trichloride.pdf

20. Abraham GE. The historical background of the Iodine Project http://www.optimox.com/pics/Iodine/IOD-08/IOD_08.htm

21. Abraham GE and Brownstein D. A Rebuttal of Dr. Gaby’s Editorial on Iodine. (2005) Townsend Letter, The Examiner of Alternative Medicine, http://www.townsendletter.com/Oct2005/gabyrebuttal1005.htm

22. Christianson A. http://www.integrativehealthcare.com/why-i-discourage-high-dose-iodine/

23. Dach J. http://jeffreydachmd.com/iodine_is_safe

24. Gaby A. http://www.townsendletter.com/AugSept2005/gabyiodine0805.htm

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