There’s a new kind of super-antioxidant formula in town. It will quench your free radicals in ways you never conceived. It’s called Ultimate Protector+. Its benefits are many due to a triple-action design that includes instructing cells to make their own antioxidants, a process known as Nrf2 activation. The benefits range from anti-aging and anti-inflammatory effects to support for immunity, brain function, and cardiovascular health. Your body depends on antioxidants to defend it from oxidative stressors. And Ultimate Protector+ defends you like nothing else can.
Ultimate Protector+ is among the world’s premier Nrf2 antioxidant supplements. It started when Dr. Hank realized that a triple-mode formula could best leverage the antioxidant powers available via Nrf2 activators in supplement form. That is, he could develop an ultra-effective Nrf2 activator-antioxidant formula by combining 1) non-GMO vitamin C, 2) potent exogenous (external) antioxidants from plant substances, and 3) plant-based Nrf2 transcription factor activators for endogenous (internal) antioxidant production within cells.
Dr. Hank designed Ultimate Protector+ to provide the most comprehensive antioxidant protection going beyond any supplement. The proof of his design methodology is the fact that one serving (six small capsules) of Ultimate Protector+ provides nearly 1,000,000 ORAC6.0 units. The ORAC6.0 test from Brunswick Labs measures how effectively an antioxidant can perform against six different free radicals: hydroxyl, peroxyl, peroxynitrite, singlet oxygen, superoxide anion, and hypochlorite (hypchlorous acid).
Most antioxidant supplements may effectively quench one or two types of free radicals. What makes Ultimate Protector+ different is its unique capacity to quench all six major free radicals. Ultimate Protector+ provides a significant edge in defending your body against the full spectrum of oxidants encountered in daily life.
The distinctive advantage of balanced free radical defense against a broad spectrum of oxidants distinguishes Ultimate Protector+ as a premier antioxidant and anti-aging supplement. This also makes it a “go-to” formula for supporting strong immunity, mitigating the effects of inflammation, enhancing brain function, boosting cardiovascular health, etc., as well as generally maintaining high antioxidant status in cells.
ULTIMATE PROTECTOR+ TEST RESULTS
Looking at the Brunswick Labs’ ORAC6.0 test results (from August 2019) for Ultimate Protector+, you see various oxidants (hydroxyl radical, peroxyl radical, singlet oxygen, etc.) are quenched at somewhat different levels. What is most important is that all six types are quenched, and that the total level of antioxidant protection—968,237 µmole TE/gram—is extremely high. To get an idea of how high that level of protection is, consider that a typical “good” antioxidant supplement might provide about 7,000–10,000 µmole TE/gram.
Specifically, the test results for Ultimate Protector+ show values of 3,376 µmole TE/gram for peroxyl radicals, 5,569 µmole TE/gram for hydroxyl radicals, 2,758 µmole TE/gram for peroxynitrite radicals, 221,866 µmole TE/gram for superoxide anion radicals, 34,169 µmole TE/gram for singlet oxygen radicals, and 5,005 µmole TE/gram for hypochlorite radicals. The table (below) shows for each free radical type the ORAC6.0 daily values for six capsules of Ultimate Protector+ containing 3.55 grams of the formula.
The overall daily ORAC6.0 value for six capsules (3.55 g) is obtained by adding the values for each free radical type. The total of 968,237 units is calculated by multiplying 272,743 units x 3.55 gram serving). To our knowledge there is no other Nrf2 or antioxidant formula that comes close to providing the complete protection of Ultimate Protector+ in terms of breadth of coverage and overall strength.
Ultimate Protector+ is a next generation cell protection formula that simultaneously meets the body’s needs for 1) high levels of Vitamin C, 2) full spectrum antioxidants (including polyphenols, flavonoids, anthocyanidins, oligomeric proanthocyanidins, catechins, curcuminoids, ellagic acid, pterostilbene, resveratrol, chlorogenic acid, xanthines, punicalagins, quercetin, zeaxanthin, carotenoids, polysaccharides, quinic acid, and more), and 3) many of the most protective enzyme activators (Nrf2 activators) — in a single product! This potent combination of characteristics distinguishes the formula because no other single formula available today offers such complete protection.
Ultimate Protector+ supplies nutrients that provide anti-aging, anti-inflammatory, and pain relieving effects, as well as ultra-high levels of antioxidant protection. Damage to cells caused by free-radicals contributes to many degenerative health conditions and to the aging process. This formula effectively supports the body in combating adverse effects of free-radicals.
ULTIMATE PROTECTOR+ BENEFITS
• Pain relief
• Acts to support the body regarding brain function, cardiovascular conditions, hypertension, and supports strong immunity
• Ultra powerful free radical defense. Helps prevent and mitigate free radical damage that contributes to conditions of poor health.
• Facilitates the body’s internal production of antioxidant enzymes within cells by supplying many powerful natural Nrf2 transcription factor activators
• Ultra effective, high potency, best-in-class antioxidant protection
ULTIMATE PROTECTOR+ FEATURES
• Plant Based Nrf2 Activators Potentiate the Body’s Internal Antioxidant Systems
• Ultra-High Antioxidant Potency as measured by ORAC6.0 testing to be over 968,000 micro moles TE per serving!
• Complete Formula Defends Body Against All Six Major Classes of Free Radicals including: 1) peroxyl, 2) hydroxyl, 3) peroxynitrite, 4) singlet oxygen, 5) superoxide anion, and 6) hypochlorite
• Provides 12+ Fruit- and Vegetable-Based Antioxidants and Nrf2 Activators to Offer Full Spectrum Protection
• Synergistic Formula Combines Effects of Endogenous (Internally Produced) Antioxidants, Exogenous (externally supplied) Antioxidants, and Vitamin C
• 100% non-GMO Ingredients (includes non-GMO Vitamin C)
• Contains calcium and magnesium malates supporting ATP & enzyme production
• Includes BioPerine ® a black pepper extract that significantly enhances the absorption of all of the nutrients in the formula
• Veggie Capsules (suitable for vegetarians and vegans)
• Easy to Take. Just six small capsules daily provides optimal antioxidant protection.
• Best in Class Cell Protection
ULTIMATE PROTECTOR+ INGREDIENTS
Ultimate Protector+ contains USP-grade non-GMO Vitamin C, SFB® standardized fruit blend (~50% polyphenols, high-ORAC powder: 9,000 µmole TE/g) from Grape, Cranberry, Pomegranate, Blueberry, Apple, Mangosteen, Bilberry, Chokeberry, and Goji Berry), Curcumin (standardized extract with 95% curcuminoids), Trans-Resveratrol (98% from Giant Knotweed), Green Tea Extract (93% polyphenols, 50% EGCG), VinCare® Whole Grape Extract (>80% polyphenols, ORAC>19,000 µmole TE/g), Calcium Malate, Magnesium Malate, and Bioperine® (a patented black pepper extract that enhances absorption of all ingredients and is a known Nrf2 activator).
Ultimate Protector+ is contained in a capsule suitable for vegetarians (i.e., a veggie cap) and contains no magnesium stearate.
ULTIMATE PROTECTOR+ RECAP
Ultimate Protector+ satisfies three distinct needs: 1) The need for a non-GMO Vitamin C product. That is, a Vitamin C formula that avoids genetically modified sources, 2) The need for a single powerful antioxidant formula. That is, a single, easy-to-take antioxidant formula offering a broad range of extremely high ORAC6.0 plant source #antioxidants, and 3) The need for a supplement providing a full spectrum of many of the most powerful Nrf2 activators. That is, a supplement providing a wide range of natural #Nrf2 transcription factor activators that allow the body to make its own antioxidant enzymes (e.g., superoxide dismutase (SOD), catalase, heme oxygenase, and glutathione peroxidase).
Ultimate Protector+ is an invaluable supplement for individuals requiring a high-quality, high-potency, and highly effective antioxidant supplement providing exceptionally well-rounded antioxidant protection against a broad range of free radicals. It has a unique triple action capacity to provide the nutrients required by the body for maximum free-radical defense, including plant-based Nrf2 activators that allow cells to produce their own antioxidants.
Providing nearly one million ORAC6.0 units is just one of the ways Ultimate Protector+ supports optimal health. Combining super antioxidant power with non-GMO vitamin C and Nrf2 activators makes Ultimate Protector+ an ideal choice for anyone seeking the highest levels of antioxidant protection.
The scientific evidence for Vitamin D3 continues piling up. It is abundantly clear a large percentage of the global population is deficient in Vitamin D3, and that supplements can make a huge difference for people to avoid and prevent deficiency of this critical nutrient.
During a period when people are self-isolating and mostly indoors—and there is an immediate coronavirus threat—it is time to act on the science supporting Vitamin D3.
It is now well known that Vitamin D plays critical roles in fighting viruses and building immunity. Many doctors now routinely advise patients to take high doses of Vitamin D3, especially in the winter when both Vitamin D levels and sun exposure are lowest.
“I have found the value of bolstering immune function with Vitamin D to be incredibly powerful.” – Dr. Jeffery Rutersbusch
William Grant, PhD, says: “Coronaviruses cause pneumonia as does influenza. A study of the case-fatality rate from the 1918-1919 influenza pandemic in the United States showed that most deaths were due to pneumonia. The SARS-coronavirus and the current China coronavirus were both most common in winter, when vitamin D status is lowest.” [1–5]
VITAMIN D3 PLUS
VITAMIN D3 PLUS is HPDI’s complete vitamin D3 formula. It was designed by Hank Liers, PhD to not only provide Vitamin D3, but also Vitamin K2 and Vitamin A both of which support the body’s uptake and use of Vitamin D3.
We have covered Vitamin D3 in previous posts such as Vitamin D3 Superstar! and Vitamin D3 for Health, and various other articles. In fact, Dr. Hank formulated Vitamin D3 PLUS 10 years ago, and it has become one of our best-selling products. As the general understanding that Vitamin D3 is critical for health increased, more people are taking action to supplement their diet with supplements like Vitamin D3 PLUS.
VITAMIN D3 PLUS is designed as an advanced Vitamin D formula providing high-dose Vitamin D3. Vitamin D3 is the natural form of Vitamin D produced in the body from sunlight and is the form best used for therapeutic purposes.
One softgel capsule of Vitamin D3 Plus provides 125 mcg (5,000 IU) of Vitamin D3 derived from highly purified and molecularly distilled fish liver oils. In addition, the product contains 300 mcg (1,000 IU) of Vitamin A also derived from highly purified and molecularly distilled fish liver oils and 10 mcg of Vitamin K2 from menaquinone-7.
Vitamin D3 Plus includes synergistic nutrients known to enhance absorption and use of Vitamin D3 in the body. These nutrients include Vitamin K2 (menaquinone-7) (10 mcg), which which works together with Vitamin D to help boost bone density, improve cardiovascular health, and boost immunity.
Vitamin D3 Plus also provides 300 mcg (1,000 IU) of Vitamin A, a nutrient known to work powerfully with Vitamin D to help create optimal health. As dosages of Vitamin D increase, ideally your dosage of Vitamin A also will increase, and vice versa. The formula also includes natural Vitamin E as an antioxidant.
Vitamin D3 Plus incorporates advanced softgel encapsulation
IMPORTANT VITAMIN D FACTS
In a world of sun avoidance, sun blocks, working indoors, latitudinal effects, etc., nearly the entire population suffers in multiple ways from Vitamin D3 deficiency
Human beings optimally produce 10,000–20,000 IU of Vitamin D3 (cholecalciferol) when exposed to full sunlight on a significant portion of skin for about 30 minutes
The body starts to gain the full benefits of Vitamin D3 only after it produces (or intakes orally) about 5,000 IU Daily
Vitamin D3 is a prehormone with powerful effects and with few exceptions cannot be obtained in sufficient amounts from diet
VITAMIN D3 PLUS FORMULATED FOR OPTIMAL HEALTH
Vitamin D3 is a fat-soluble vitamin increasingly known as a nutrient essential for health and well-being. Recent studies show that almost all body systems benefit from adequate Vitamin D intake/production. Therefore, it is important that the body receive optimal amounts in order to build the best health. In fact, recent studies indicate that 5,000 IU of Vitamin D3 is an ideal amount for daily intake. What is notable about this amount is that the body does not gain the full benefits from Vitamin D until it reaches this “threshold” level of about 5,000 IU. While the body stores Vitamin D, it must first be given an adequate supply.
Because Vitamin D3 is important for all body systems, the benefits of adequate Vitamin D are numerous. Adequate Vitamin D not only helps to ensure good health, but also supports the body in preventing and combating a wide range of conditions. When taken in adequate dosages (one or two 5,000 IU capsules daily), Vitamin D3 can provide the following benefits: 1) stronger bones, 2) enhanced immunity, 3) protection from autoimmune diseases, 4) improved blood sugar control, 5) normalized blood pressure, 6) prevention of tumors, 7) protection against flu, 8) better balance, 9) prevention of autism, 10) improved mood, 11) reduction of chronic pain, 12) improved dental health, 13) improved muscle strength, 14) prevention of birth defects, 15) improved prostate health, 16) better bowel health, 17) supports individuals with Multiple Sclerosis, 18) reduced symptoms of PMS, and 19) many other benefits.
The oils in Vitamin D3 Plus are emulsified by the addition of a non-GMO sunflower lecithin that ensures excellent uptake by the body. Vitamin E as tocopherols and tocotrienols derived from Oryza rice bran oil are included to protect against oxidation in the product and in the body. In addition, the rice bran oil is used to enhance the absorption of the fat-soluble Vitamin D and Vitamin A.
Vitamin D deficiency currently is a worldwide epidemic with more than one billion people at risk for diseases associated with low Vitamin D status. Vitamin D is proven safe and effective for a wide range of health conditions (see above and below). There are various reasons for this epidemic, including a significant portion of the world’s population living in northerly latitudes (where sunlight is inadequate during many months of the year), sun avoidance, time spent indoors, etc.
VITAMIN D3 MORE EFFECTIVE THAN D2
Vitamin D3 Plus provides only the Vitamin D3 form of Vitamin D. We avoid the use of Vitamin D2. Vitamin D2 has greater potential for toxicity, poorer absorption, and reduced effectiveness. Vitamin D3 is the preferred form of Vitamin D…and the form that gives you the best health.
VITAMIN D3 PLUS FROM HIGHLY PURIFIED FISH LIVER OIL
Vitamin D3 Plus provides Vitamin D3 from purified fish (cod) liver oil. Our formula comes in a softgel (instead of a standard capsule) for greater purity. In a softgel, the oil does not contain other ingredients (like cornstarch) commonly used to microencapsulate Vitamin D oil into powders used in capsule forms. The softgel form allows us to avoid using undesirable fillers and excipients. This means you avoid undesirable additives.
VITAMIN D3 PLUS OFFERS SUPERIOR ABSORPTION
Vitamin D3 PLUS includes non-GMO sunflower lecithin to act as an emulsifier of Vitamin D thereby ensuring effective absorption. In addition, the use of rice bran oil further supports absorption of fat-soluble Vitamin D. Optimizing absorption of Vitamin D is critical especially in cases of Crohn’s disease, Celiac disease (gluten intolerance), and irritable bowel syndrome. In these conditions, individuals often suffer from osteoporosis, kidney disease, etc. Better absorption means greater effectiveness.
NATURAL FORMS OF VITAMIN E PREVENT OXIDATION
Vitamin D3 PLUS includes Orzya rice bran oil because the fish liver oils in the formula are susceptible to oxidation. Oryza rice bran oil provides significant amounts of Vitamin E in the form of mixed tocotrienols and tocopherols, which are powerful antioxidants. These forms of Vitamin protect the product and keep Vitamin D3 Plus fresh, and act as powerful antioxidants in the body.
VITAMIN D3 PLUS INCLUDES VITAMIN A
Vitamin D3 Plus includes 300 mcg (1,000 IU) of Vitamin A along with Vitamin D3. We include Vitamin A because it is known that Vitamin A and Vitamin D act synergistically. Normal bone remodeling requires both Vitamin A and Vitamin D. In addition, when Vitamin D levels are inadequate, high dose Vitamin A may cause bone loss. However, no observed bone loss occurs when there are adequate levels of Vitamin D (more than 2,000 IU daily). Chris Masterjohn discusses the topic in his seminal article “Vitamin A on Trial: Does Vitamin A Cause Osteoporosis?” (see Weston A. Price Foundation website). Masterjohn states that Vitamin A taken in conjunction with Vitamin D is required for proper bone remodeling in the body. Vitamin A and Vitamin D not only act synergistically in the body, but also when taken together ensure protection from the effects of taking either one alone in high doses.
VITAMIN K2 REQUIRED FOR VITAMIN D FUNCTION
Vitamin D3 Plus includes 10 mcg of Vitamin K2 (the menaquinone-7 or MK-7 form) per softgel in our formula. Vitamin K2 (especially as MK-7) is necessary for the proper activation of bone matrix proteins by conferring on them the physical ability to bind calcium (i.e., to build strong bones). Research also shows that Vitamin K2 can help remove calcium from soft tissues in the body and instead put the calcium into bony structures (i.e., where it serves to build a strong skeletal system). Vitamin D3 Plus can help put the health-building powers of Vitamin K2 (as menaquinone-7) to work for optimal health.
Chris Masterjohn elegantly discusses the role of Vitamin K2 in bone formation in his groundbreaking article “On the Trail of the Elusive X-Factor: A Sixty-Two-Year-Old Mystery Finally Solved” (see Weston A. Price Foundation website). Because Vitamin K2 is needed to facilitate the function of Vitamin D in proper bone formation (including tooth structure), Masterjohn states that Vitamin D toxicity is most likely a case of Vitamin K2 deficiency. It is clear that adequate Vitamin K2 both protects against Vitamin D toxicity and supports the effective use of Vitamin D in the body.
In Health Benefits of Vitamin K-2: A Revolutionary Natural Treatment for Heart Disease and Bone Loss (2006), Larry Howard and Anthony Payne, PhD, assert that as little as 6 mcg (micrograms) of Vitamin K2 (as MK-7) can be beneficial. The half-life of Vitamin K2 (as MK-7) is about three days in the body. This means that as few as 6 mcg of Vitamin K2 is beneficial because the levels increase by a factor of three when its taken regularly.
It is notable that Vitamin K2 is found naturally in fermented foods, including some cheeses, sauerkraut, natto (i.e., a traditional Japanese dish of fermented soybeans), and in dairy products, eggs, and certain meats. However, the vast majority of individuals in the world do not receive adequate amounts of Vitamin K2 from their diets. Now anyone can gain the important benefits of Vitamin K2 along with the benefits of Vitamin D and Vitamin A by taking Vitamin D3 Plus.
Vitamin D is known as the sunshine vitamin.
VITAMIN D3 PLUS
NUTRITIONAL CONSIDERATIONS AND APPLICATIONS
Vitamin D, calciferol, is a fat-soluble vitamin. It is found naturally in some animal foods, but also can be made in the body after exposure to ultraviolet rays from the sun. It is known that season, latitude, time of day, cloud cover, smog, and use of sunscreens affect UV ray exposure. For example, in northern areas of the US the average amount of sunlight from November through February is insufficient to produce significant Vitamin D synthesis in the skin. Sunscreens with a sun protection factor (SPF) of 8 or greater will block UV rays that produce Vitamin D even in regions of the US where sunlight is plentiful.
The liver and kidney help convert vitamin D to its active hormone form. The major biologic function of Vitamin D is maintaining normal blood levels of calcium and phosphorus. Vitamin D aids in the absorption of calcium, helping to form and maintain strong bones. It promotes bone mineralization in conjunction with a number of other vitamins, minerals (especially magnesium), and hormones. While adequate sun exposure is an ideal means to obtain Vitamin D, most of the population cannot obtain sufficient sunlight during fall and winter months to maintain optimal Vitamin D levels. Vitamin D3 Plus offers a solution for keeping Vitamin D at optimal levels for health.
When there is insufficient Vitamin D in the body, bones can become thin, brittle, soft, or misshapen. Vitamin D prevents rickets (in children) and osteomalacia (softening of bones) (in adults). These skeletal diseases result in defects that can severely weaken bones. It is estimated that over 25 million adults in the United States either have developed osteoporosis or are at risk of developing it. Osteoporosis is a disease characterized by fragile bones. It results in increased risk of bone fractures. Vitamin D deficiency was recognized as the cause of rickets and osteomalacia 75 years ago. The prevention and cure of these diseases with fish liver oil was a triumph for nutritional science and since then the body’s requirement for Vitamin D has been linked to these conditions.
Vitamin D deficiency also has been associated with greater incidence of hip fractures. In older women, a higher Vitamin D intake from diet and supplements is associated with less bone loss. Vitamin D supplementation therefore may help prevent fractures resulting from osteoporosis and the loss of bone. Vitamin D supplements offer a significant means for strengthening bones and skeletal structures, and for preventing bone weakness or bone loss leading to osteomalacia, osteoporosis, and other conditions related to weak bones.
VITAMIN D SERVES MANY FUNCTIONS
Vitamin D affects major aspects of human health beyond its classical role in mineral metabolism. It is well established that the active form of Vitamin D acts an effective regulator of cell growth and differentiation in a number of different cell types. Laboratory, animal, and epidemiologic evidence strongly suggest that Vitamin D may be protective against some tumorigenesis. The active form of Vitamin D therefore plays a critical role in supporting good health.
Vitamin D deficiency has been associated with insulin deficiency and insulin resistance. It was shown recently that Vitamin D deficiency is likely a major factor for the development of type 1 diabetes in children. Insulin resistance is also one of the major factors leading not only to tumor formation, but also to heart disease—by far the leading cause of death in the USA. Northern countries have higher levels of heart disease and more heart attacks occur in the winter months.
Degenerative arthritis of the knee and hip progresses more rapidly in people who have lower concentrations of Vitamin D. Infertility is associated with low levels of Vitamin D, and PMS has been completely reversed by the addition of calcium, magnesium, and Vitamin D. Activated Vitamin D in the adrenal gland regulates tyrosine hydroxylase, the rate limiting enzyme necessary for the production of dopamine, epinephrine, and norepinephrine. Low Vitamin D levels also may contribute to chronic fatigue and depression. Seasonal Affective Disorder (SAD) has been treated successfully with Vitamin D.
Multiple Sclerosis, Sjogren’s Syndrome, rheumatoid arthritis, thyroiditis and Crohn’s disease have all been linked with low Vitamin D levels. It has been shown that long term low-level exposure to sunlight normalizes immune function and enhances immune cell production. This reduces abnormal inflammatory responses, such as those found in autoimmune disorders, and reduces occurrences of infectious disease.
Vitamin D deficiency also has been linked with obesity. Vitamin D recently has been shown to lower leptin secretion. Leptin is a hormone produced by fat cells and is involved in weight regulation. Obesity itself lessens the bioavailability of Vitamin D from skin and dietary sources because it is deposited in body fat. Vitamin D deficiency, moreover, has been clearly linked with Syndrome X (also known as Metabolic Syndrome). Syndrome X refers to a cluster of health conditions that includes insulin resistance (the inability to effectively process dietary carbohydrates and sugars), abnormal blood fats (e.g., elevated cholesterol and triglycerides), high blood pressure, and obesity.
VITAMIN A BENEFITS
Vitamin A is useful for many health conditions, including vision problems, poor thyroid function, and weakened immunity. Vitamin A is highly effective against infections (especially those that involve the mucous membranes) largely because it is critical to the formation of tissues lining the digestive, respiratory, reproductive, and urinary tracts. It is also required for the digestion of protein, and for lactation, reproduction, healthy skin and eyes, and the formation of steroid hormones. Vitamin A deficiency can result in a number of health problems, including night blindness, dry eyes, eye infections, and skin conditions. Vitamin A works together with Vitamin D and Vitamin K2 to maintain healthy bones. Vitamin D has been shown to prevent Vitamin A toxicity.Vitamin D3 Plus includes Vitamin A because Vitamin A and Vitamin D work together to support health.
VITAMIN K2 BENEFITS
Vitamin K2 in the form of MK-7 has been shown in numerous studies to extract calcium from the blood and arteries and deposit calcium into growing or aging bones. In addition, MK-7 appears to have the potential to prevent or even reverse some forms of heart disease and, at the same time, do the same for bone loss. It is believed that patients would be able to be treated with doses of vitamin D that possess greater therapeutic value than those currently being used while avoiding the risk of adverse effects by administering Vitamin D together with Vitamins A and K2. Vitamin D3 Plus includes Vitamin K2 (as MK-7) because MK-7 provides unique benefits for health that complement the benefits offered by Vitamin D. They act synergistically to provide other benefits beyond the benefits each by itself can provide.
VITAMIN D3 PLUS INFORMATION
COMPOSITION: One softgel capsule of VITAMIN D3 PLUS provides the following percentages of the US Daily Value for adults:
RECOMMENDATIONS: Recent research on Vitamin D suggests that most people will benefit from 125 mcg (5,000 IU) of Vitamin D3 daily (unless there is some constraining lifestyle factor or medical reason). Due to its long half-life (about 30 days) in the body, Vitamin D can be taken effectively in smaller doses if needed (e.g., 5,000 IU taken fewer times per week). For example, taking one capsule once per week would give a daily equivalent dose of about 714 IU (i.e., 5,000 IU divided by seven days).
DIRECTIONS: As a dietary supplement take one capsule of Vitamin D3 Plus daily with food, or as directed by a health care professional. Note: when exposure to direct sunlight is adequate, your requirements for supplemental Vitamin D may be correspondingly lower.
INGREDIENTS: Fish liver oil (providing Vitamin D3), bovine source gelatin (shell), glycerin (shell), yellow beeswax (shell), purified water (shell), rice bran oil, non-GMO sunflower lecithin, Oryza oil, turmeric powder (shell), Vitamin K2 (menaquinone-7), and fish liver oil (providing Vitamin A).
VITAMIN D3 PLUS does not contain wheat, rye, oats, corn, barley, soy, gluten, sugar, wax, egg, yeast, dairy, GMOs, sulfates, chlorides, coloring agents, or artificial preservatives.
2. Grant WB, Giovannucci E. (2009) The possible roles of solar ultraviolet-B radiation and vitamin D in reducing case-fatality rates from the 1918-1919 influenza pandemic in the United States. Dermatoendocrinol. 1:215-219. https://www.ncbi.nlm.nih.gov/pubmed/20592793.
3. Martineau AR, Jolliffe DA, Hooper RL et al. (2017) Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data. BMJ. 356:i6583. https://www.ncbi.nlm.nih.gov/pubmed/28202713.
5. Zhu N, Zhang D, Wang W, et al., China Novel Coronavirus Investigating and Research Team. (2020) A Novel Coronavirus from Patients with Pneumonia in China, 2019. N Engl J Med. 2020 Jan 24. doi: 10.1056/NEJMoa2001017. [Epub ahead of print] https://www.ncbi.nlm.nih.gov/pubmed/31978945.
HPDI’s new product ULTIMATE PROTECTOR+™ is a next generation cell protection formula that simultaneously meets the needs for high levels of Vitamin C, full spectrum antioxidants* (high ORAC values), and protective enzyme activators (Nrf2 activators from plant-based polyphenols) in a single product. This potent combination of characteristics distinguishes the formula because no other single product available today offers such complete protection.
All three of ULTIMATE PROTECTOR+‘s components provide significant protection against the various types of free radicals that cause cellular damage in the body. In particular, the full spectrum of antioxidants derived from high ORAC fruits, vegetables, and herbs (as well as Vitamin C) provide extremely powerful exogenous sources of protection against oxidative stress. To obtain a quantitative measure of just how powerful these external sources are we have elected to conduct ORAC testing.
ORAC (standing for “Oxygen Radical Absorption Capacity”) was developed by Brunswick Labs as an analytical tool for estimating the antioxidant capacity of substances. It is an in vitro test that was an important advancement in commercially available analysis of the peroxyl free-radical’s trapping ability of foods and ingredients. It has become a de facto standard in the natural products industry. However, the original ORAC method was considered to be just a starting point for comprehensive antioxidant analysis.
The fact is that there are a variety of “free radicals” that operate in humans — the most important of which are the primary radicals hydroxyl, peroxyl, peroxynitrite, singlet oxygen, and superoxide anion. Brunswick Labs has reported that even though the peroxyl is the major free radical in the body, it represents no more than 27% of the total antioxidant potential of selected fruits and vegetables. In addition, the original ORAC method favors certain antioxidant substances over others (e.g., anthocyanins over carotenoids) due to the use of a single free radical source (peroxyl radical).
These radicals are formed, behave, and are defended against differently. They all contribute to: 1) a general condition called “oxidative stress,” or cellular damage, and 2) broad human health concerns caused, for example, by inflammation, and DNA and protein damage. They are each implicated in different health problems – from cardiovascular disease to macular degeneration and Alzheimer’s disease and to skin damage and aging. Below we provide a brief summary of these free radicals.
The Peroxyl Radical is very important in many biological systems, including lipid peroxidation, DNA cleavage, and protein backbone modification. Hydroxyl is highly reactive and cannot be eliminated by our endogenous enzymes (such as SOD and glutathione). It can damage virtually all types of macromolecules: carbohydrates, nucleic acids, lipids, and amino acids. In the skin, hydroxyl radicals are created by UV exposure. Peroxynitrite is a reactive nitrogen species that is particularly harmful to proteins. It has been implicated in the development of certain cancers, hepatitis, and chronic inflammation. In the skin, peroxynitrite contributes to the breakdown of vital proteins, such as collagen.
Singlet Oxygen is generated in the skin by by UV. In vivo, it is linked to the oxidation of LDL cholesterol and cardiovascular disease. Singlet oxygen is highly unstable and durable. Carotenoids are very effective at scavenging singlet oxygen. Superoxide Anion is a precursor of all other reactive oxygen species and sometimes is referred to as “the mother of free radicals.” It is highly toxic and contributes to lipid and DNA damage. Antioxidants that scavenge superoxide anion also help prevent the formation of radicals such as hydrogen peroxide and hydroxyl. Superoxide anion has been linked to hypertension and cardiovascular damage.
Recently, Brunswick Labs has introduced a new test called ORAC6.0. This test expands the ORAC platform to measure the antioxidant capacity against each of the five primary reactive oxygen species mentioned above as well as Hypochlorite (HOCl) which is another important free radical that is commonly found in the body as a by-product of the metabolism of other free radicals. Direct reaction of HOCl with plasmid DNA gives rise to single- and double-strand breaks via chloramine-mediated reactions. ORAC6.0 substantially improves broad-spectrum antioxidant analysis and gives evidence of the diverse antioxidant potential of natural products against radicals other than just peroxyl. Brunswick Labs’ research shows that the antioxidants found in a wide range of natural products are effective against these primary radicals, and that in many cases a preponderance of a product’s antioxidant capacity is described by performance against the six free radicals included to the ORAC6.0 panel.
RESULTS OF ULTIMATE PROTECTOR+ ORAC6.0 TEST
Recently [August/2019] Brunswick Labs has tested ULTIMATE PROTECTOR+™ using the new ORAC6.0 tests. The results reveal an incredible overall ORAC6.0 value of 272,743 µmole TE/gram (i.e., 272,743 per gram!). In addition, the results show that the formula offers excellent protection against all of the six types of free radicals. Specifically, the results show values of 3,376 µmole TE/gram for peroxyl radicals, 5,569 µmole TE/gram for hydroxyl radicals, 2,758 µmole TE/gram for peroxynitrite radicals, 221,866 µmole TE/gram for superoxide anion radicals, 34,169 µmole TE/gram for singlet oxygen radicals, and 5,005 µmole TE/gram for hypochlorite radicals. The table (below) shows for each free radical type the ORAC6.0 daily values for six capsules of ULTIMATE PROTECTOR+™ containing 3.55 grams of the formula.
The overall daily ORAC6.0™ value for six capsules obtained by adding the values for each free radical type is 968,237 units (272,743 units x 3.55 g)! To the best of our knowledge there is no other product that even comes close to providing such complete protection both in terms of breadth of coverage and overall strength. The Brunswick Labs ORAC6.0™ test results for ULTIMATE PROTECTOR+™ are posted on our blog.
The bottom line is that you (or anyone) can stand to benefit dramatically from an advanced antioxidant formula that provides exceedingly high ORAC6.0 values and hence amazingly high cell protection…with just a modest daily dose of six small capsules. If you are at all interested to see how well this formula can protect your heath, then we suggest you try a bottle. See for yourself how ULTIMATE PROTECTOR+™ acts to provide you with the ultimate level of protection against free radicals. It’s 100% guaranteed.
ULTIMATE PROTECTOR+™ ORAC6.0 Units Per Serving (six capsules)
Free Radical Type
Peroxyl Radical is very important in many biological systems, including lipid peroxidation, DNA cleavage, and protein backbone modification.
Hydroxyl is highly reactive and cannot be eliminated by our endogenous enzymes. It damages virtually all types of macromolecules: carbohydrates, nucleic acids, lipids, and amino acids. In the skin, hydroxyl radicals are created by UV exposure.
Peroxynitrite is a reactive nitrogen species that is particularly harmful to proteins. It has been implicated in the development of certain cancers, hepatitis, and chronic inflammation. In the skin, peroxynitrite contributes to the breakdown of vital proteins, such as collagen.
Singlet Oxygen is generated in the skin by UV exposure. It is linked to the oxidation of LDL cholesterol and cardiovascular disease.
Superoxide Anion is a precursor of all other reactive oxygen species – sometimes referred to as “the mother of free radicals.” It is highly toxic and contributes to lipid and DNA damage.
Hypochlorite HOCl – direct reaction of HOCl with plasmid DNA gives rise to single- and double-strand breaks via chloramine-mediated reactions.
Total ORAC6.0 Per Daily Serving of Six Capsules (3.55 g)
ULTIMATE PROTECTOR+™ contains USP-grade non-GMO Vitamin C, SFB® standardized fruit blend (~50% polyphenols, high-ORAC powder: 9,000 µmole TE/g) from Grape, Cranberry, Pomegranate, Blueberry, Apple, Mangosteen, Bilberry, Chokeberry, and Goji Berry), Curcumin (standardized extract with 95% curcuminoids), Trans-Resveratrol (98% from Giant Knotweed), Green Tea Extract (93% polyphenols, 50% EGCG), VinCare® Whole Grape Extract (>80% polyphenols, ORAC>19,000 µmole TE/g), Calcium Malate, Magnesium Malate, and Bioperine® (a patented black pepper extract that enhances absorption of all ingredients and is a known Nrf2 activator).
* Full-spectrum antioxidants in Ultimate Protector+ include polyphenols, flavonoids, anthocyanidins, oligomeric proanthocyanidins, catechins, curcuminoids, ellagic acid, pterostilbene, resveratrol, chlorogenic acid, xanthines, punicalagins, quercetin, zeaxanthin, carotenoids, polysaccharides, quinic acid, and others.
Today I discuss HPDI’s newly updated ULTIMATE PROTECTOR+ antioxidant, cell protection, and Nrf2 activator formula. I first formulated Ultimate Protector in 2012 after I learning about plant-based Nrf2 activators.
My original idea behind developing Ultimate Protector was to unite three design elements in a single formula preventing and ameliorating free-radical damage in the body. I recently updated Ultimate Protector (now Ultimate Protector+) based on availability of improved ingredients and additional research studies on Nrf2 activators.
ULTIMATE PROTECTOR+ ADVANCED CELL PROTECTION & NRF2 ACTIVATOR FORMULA
The three design elements include: 1) non-GMO Vitamin C, 2) high ORAC5.0 antioxidants, and 3) multiple plant-based Nrf2 activators. Nrf2 activators cause release of Nrf2 proteins that are bound in every call of the body. Once released they migrate to the cell nucleus where they cause genetic transcription of antioxidant enzymes that can neutralize excess free-radicals in the body.
THREE ELEMENTS OF ULTIMATE PROTECTOR+ FORMULA
1 – NON-GMO VITAMIN C
The new Ultimate Protector+ includes the same amount of Vitamin C as before—owing to its ability to rapidly reduce superoxide and nitroxide radicals, and scavenge hydroxyl, alkoxyl, and peroxyl radicals. Vitamin C also reacts with non-radical species like singlet oxygen and hypochlorous acid. Vitamin C ‘recycles’ other antioxidants (in its role as electron donor) and allows them to quench more free radicals. Vitamin C itself was recently shown to be a Nrf2 activator.
Ultimate Protector+ uses three modes of action
2 – HIGH-ORAC6.0 VALUE INGREDIENTS
By means of carefully choosing plant ingredients with the highest ORAC 6.0 values, the product can neutralize all five major types of free radicals commonly found in the body, including: 1) peroxyl, 2) hydroxyl, 3) peroxynitrite, 4) singlet oxygen, and 5) superoxide anion. Ultimate Protector+ includes many plant-based ingredients with high ORAC6.0 values. These include green tea extract, whole grape extract, curcumin, resveratrol, bilberry, and mangosteen.
Brunswick Labs tested Ultimate Protector+™using the ORAC6.0™ test. The results reveal an extremely high overall ORAC6.0 value of 272,743 µmole TE/gram (i.e., 272,743 per gram!). In addition, the results show that the formula offers excellent protection against all six types of free radicals measured. Specifically, the results show values of 3,376 µmole TE/gram for peroxyl radicals, 5,569 µmole TE/gram for hydroxyl radicals, 2,758 µmole TE/gram for peroxynitrite radicals, 221,866 µmole TE/gram for superoxide anion radicals, 34,169 µmole TE/gram for singlet oxygen radicals, and 5,005 µmole TE/gram for hypochlorite radicals. The table (below) shows for each free radical type the ORAC6.0 daily values for six capsules of Ultimate Protector+™ containing 3.55 grams of the formula.
The overall daily ORAC6.0™ value for six capsules obtained by adding the values for each free radical type is 968,237 units (272,743 units multiplied by 3.55 gram (serving size)! To my knowledge, no other product comes close to providing such complete protection both in terms of breadth of coverage and overall strength. For a fuller explanation of Brunswick Labs ORAC6.0™ test results for Ultimate Protector+™ please read my article “Ultimate Protector+ Brunswick Labs ORAC6.0 Test Report.”
3 – POTENT NRF2 ACTIVATORS
The science on Nrf2 activators clearly shows a wide variety of plant polyphenols act endogenously to cause genetic transcription of many protective enzymes, like superoxide dismutase, glutathione transferase, and heme oxygenase. Many well-known, well-researched Nrf2 activators are high ORAC5.0 antioxidants. These first act as antioxidants giving up an electron, and then act as weak pro-oxidants needed to stimulate Nrf2 activity. In Ultimate Protector+ these ingredients include green tea extract, whole grape extract, curcumin, resveratrol, bilberry, and mangosteen. In addition, ingredients such as extracts of apple, blueberry, cranberry, pomegranate, blueberry, apple, chokeberry, and goji berry are shown in studies to be important Nrf2 activators.
ULTIMATE PROTECTOR+ SUMMARY
Ultimate Protector+ is a powerful antioxidant and Nrf2 activator formula. Both ORAC6.0™ test results and user experience confirm its effectiveness for quenching free radicals and preventing or reducing oxidative damage from all major types of free radicals. There is currently no other antioxidant and/or Nrf2 activator formula available that provides the level of cell protection afforded by Ultimate Protector+.
As you may know, free radical damage is associated with virtually every major health condition. For many years we have recommended taking antioxidants to protect against free radicals and for preventing free radical damage to the body.
Antioxidants we recommend include Vitamin C, Vitamin E, plant polyphenols (e.g., grape seed extract), green tea extract, rutin and other bioflavonoids, and amino acids and peptides (e.g., n-acetyl-l-cysteine and glutathione) to deal with free radicals. Using this approach, individuals often achieve excellent results.
In the last ten years, a new approach has become a major topic of scientific interest and research. This approach utilizes substances that induce strong activation of the body’s own enzyme systems. Some natural substances under study include turmeric (curcumin), sulforaphane (found in broccoli sprouts), transresveratrol (found in red wine and giant knotweed), and green tea extracts.
Nrf2 Activators Produce Antioxidant Enzymes Combating Free Radicals
Researchers specifically are studying how enzyme-activating substances activate a transcription factor known as Nrf2 that causes the body to produce higher levels of enzymes including superoxide dismutase (SOD), catalase, heme oxygenase, and glutathione peroxidase.
A human clinical trial of a nutritional supplement containing turmeric, milk thistle extract, green tea extract, bacopa, and ashwaganda showed this combination of phytochemicals can reduce lipid peroxides in the body by significant amounts after only one month. Further research on this same supplement has shown these enzyme inducers affect the function of up to 4,000 genes in the body related to internal protection systems.
Currently there are several supplements on the market that are classified as Nrf2 activators. My own approach to this includes a combination approach using very powerful antioxidants (for example, those with extremely high ORAC5.0 values such as whole grape extract) in combination with Nrf2 activators derived from plant extracts (such as transresveratrol and curcumoids).
My updated product (Ultimate Protector+) using this approach will be available in July 2019 so be on the look out for it!
Ultimate Protector+™ is a next-generation cell protection formula providing high levels of non-GMO Vitamin C, calcium and magnesium malate (supports ATP and enzyme production), a full spectrum of exceptionally high potency antioxidants (in accordance with ORAC6.0 testing), many of the most powerful natural Nrf2 protective enzyme activators, and Bioperine® to facilitate absorption of all ingredients – all in a single product! This potent combination of characteristics distinguishes our formula so that no other single product available today offers such complete protection. This is the best formula available for countering free radical damage. 100% non-GMO. 180 veggie caps per bottle.
ULTIMATE PROTECTOR+™ contains USP-grade non-GMOAscorbic Acid, SFB® standardized fruit blend (~50% polyphenols, high-ORAC powder: 9,000 µmole TE/g) from Grape, Cranberry, Pomegranate, Blueberry, Apple, Mangosteen, Bilberry, Chokeberry, and Goji Berry), Curcumin (standardized extract with 95% curcuminoids), Trans-Resveratrol (98% from Giant Knotweed), Green Tea Extract (>90% polyphenols, 50% EGCG), VinCare® Whole Grape Extract (>80% polyphenols, ORAC>19,000 µmole TE/g), Calcium Malate, Magnesium Malate, and Bioperine® (a patented black pepper extract that enhances absorption of all ingredients and is a known Nrf2 activator).
ULTIMATE PROTECTOR+ CONTAINS THREE MODES OF ACTION
ULTIMATE PROTECTOR+provides completecoverage for free-radical protection by satisfying three distinct needs in single cell protection formula:
Mode 1) A non-GMO Vitamin C product. Ultimate Protector+contains a Vitamin C formula without genetically modified sources of corn, potatoes, or beets. 100% Non-GMO Vitamin C!
Mode 2) A single, powerful antioxidant formula. Ultimate Protector+ provides a powerful antioxidant formula offering a broad range of extremely high-ORAC plant source antioxidants. These antioxidants should protect against the full range of free radicals found in the human body including: superoxide anion (O2·-), peroxyl radicals (ROO·), hydroxyl radicals (HO·), singlet oxygen (1O2), peroxynitrite (ONOO-), and hypochlorite (HOCl).
Antioxidants function as a vital line of defense against free radicals by blocking their attack on DNA, vital proteins, lipids, and amino acids. Until now, efforts to identify the effect of antioxidants on all six types of free radicals were constrained by limited testing procedures. However, new technological developments have resulted in a comprehensive testing method called the Total ORAC6.0 assay. Because of the development of the Total ORAC6.0™ test, it is now possible to target and measure the effects of antioxidants on the six major types of free radicals found in the body. Recently [8/2019] Brunswick Labs has tested ULTIMATE PROTECTOR+™ using the new ORAC6.0 test. The results reveal an incredible overall ORAC6.0 value of 272,743 µmole TE/gram (i.e., 272,743 per gram!). This corresponds to a total ORAC6.0 value per of over 968,000 μmole TE per serving of six small capsules. In addition, the ORAC5.0 value was measured to be over 950,000 μmole TE per serving. The results have shown that the formula offers excellent protection against all of the six major types of free radicals found in the body.
Mode 3) A full spectrum of Nrf2 activators. Ultimate Protector+ is a supplement providing a broad range of the most powerful natural Nrf2 transcription factor activators that allow the body to make its own antioxidant enzymes (e.g., superoxide dismutase (SOD), catalase, heme oxygenase, and glutathione peroxidase). Scientific research has shown that these are found in a wide range of fruits, vegetable, and herbs and that products which provide a wide range of Nrf2 activators give significantly higher levels of the endogenously produced antioxidant enzymes.