Fred Liers PhD hydrogen supplements drinks H2I love hydrogen supplements. So should you. Since starting my morning—and often afternoon—routine of making hydrogen drinks in the kitchen, I have come to appreciate the surge of energy lasting many hours, as well as a host of other benefits.

Most of all, I am amazed how easy hydrogen supplements are to use considering how much they do for you, and how well they complement the supplements I already take—seeming to make them all more effective.

I typically use one or two effervescing Active H2 Ultra tablets or Vital Reaction tablets in 8–16 ounces of water. Then I like to open one Megahydrate capsule directly in the effervescing water. I wait about 90 seconds to let the tablets stop “fizzing” and then I drink immediately. Allowing the drink to sit for a few minutes is okay, but the sooner you drink it, the higher the concentration of hydrogen.


Hydrogen supplements are among the newer, cutting-edge nutritional formulas available to support optimal health. More than 500 scientific articles now support the therapeutic potential hydrogen for essentially every organ system and in 150 human disease models, according to the non-profit Molecular Hydrogen Foundation. In fact, hydrogen is rapidly incorporated into medicine, sports medicine, peak performance, elite fitness, and more.

Hydrogen is an antioxidant. It is also an extremely small molecule that can penetrate even the tiniest cellular compartments. This helps explain how hydrogen works to offer free-radical defense throughout the entire body.

The medical and scientific literature is clear. Hydrogen’s modes of action:

  • H2 reduces oxidative stress as a selective antioxidant and by maintaining homeostatic levels of glutathione, superoxide dismutase, catalase, etc.
  • H2, like other gaseous signaling molecules (i.e. NO, CO, H2S), appears to have cell signal-modulating activity affording it with anti-inflammatory, anti-obesity, and anti-allergy benefits.

We include hydrogen supplements in HPDI’s system of Foundational Supplements. In fact, hydrogen formulas as just one of six foundational supplements. We consider hydrogen a “secondary” foundational supplement usually to be added to a supplement regimen after the four primary ones: multivitamins, antioxidant & vitamin C formulas, essential fatty acids, and superfoods high in dietary nucleic acids (i.e., Rejuvenate! superfoods).


The scientific literature discusses the use of molecular hydrogen for many clinical applications, including:

• Metabolic Syndrome including diabetes, hyperlipidemia, arteriosclerosis, hypertension, and obesity

• Ischemia/reperfusion injuries, including cerebral and myocardial infarctions, organ transplants, post-cardiac arrest

• Neuroprotection, including applications for dementia, Parkinson’s disease, depression, and anesthesia

• Inflammation, including applications for polymicrobial sepsis, rheumatoid arthritis, wound healing, and bowel diseases

• Mitochondrial diseases

• Hemodialysis and ventilation

• Aging, including cognitive decline

• Exercise, including applications for fatigue, lactic acid, recovery, and oxidative stress related to heavy exercise

Side effects of cancer therapies, including radiotherapy and chemotherapy

• Many other benefits

(Source: Molecular Hydrogen Foundation)


According to the Molecular Hydrogen Foundation, there are three ways molecular hydrogen exerts positive health effects.

1. Molecular hydrogen easily diffuses into subcellular compartments where it scavenges cytotoxic oxygen radicals, thereby protecting DNA, RNA, and proteins against oxidative stress.

2. Molecular hydrogen triggers activation or upregulation of additional antioxidant enzymes (e.g., glutathione, superoxide dismutase, catalase, and others) and/or cytoprotective proteins of the body.

3. Molecular hydrogen may be a novel signaling molecule that alters cell signaling, cell metabolism, and gene expression. This may explain its apparent anti-inflammatory, anti-allergic, and anti-apoptotic (or anti-cell death) effects.

hydrogen supplements Active H2 Ultra tablets

Active H2 Ultra hydrogen supplement (60 tablets).


Molecular hydrogen exhibits great safety, and it is regarded as safe for use in the body. It is shown no toxicity even in high concentrations.

Safety standards have long been established for high concentrations of hydrogen for inhalation largely because of the history of high-pressure H2 gas used in deep-water diving gas mixtures for preventing decompression sickness.

Notably, H2 gas combusts only at temperatures higher than 527 °C, and it explodes by chain reaction with oxygen (O2) only in the range of H2 concentration (4–75%, vol/vol).

Molecular hydrogen is used for medical applications safely by several ingestion methods including inhalation of 1–4% hydrogen gas, for example, which exhibits great effectiveness. All these factors mean that hydrogen is safe, easy-to-use, and effective for therapeutic purposes.

vital reaction hydrogen supplements

Vital Reaction hydrogen supplement (60 tablets).


According to the Molecular Hydrogen Foundation, drinking H2-rich water is the easiest, and often the most effective, method for obtaining hydrogen.

Drinking hydrogen-infused water is easy to do, and convenient as you can drink it at home or while traveling. Effective hydrogen products HPDI carries include Vital Reaction tablets, Active H2 tablets, and Megahydrate capsules.

As noted, I make one or two hydrogen drinks daily, first in the morning and then often again in the afternoon. I drink them on an empty stomach. I enjoy a significant energy boost, which helps power me through my day. I gain other benefits, including improved athletic performance, noticeably faster recovery from exercise, and an overall greater sense of well-being.

I highly recommend you try hydrogen supplements for yourself, and then consider them for your clients or patients. Our experience is that most people are pleasantly surprised by the results they get from hydrogen supplements, especially if they have a need for exceptional free-radical defense, or stand to benefit from the proven effects hydrogen uniquely provides (see list above).

Once you try hydrogen, you will want to continue taking it because the benefits are so significant. Let the power of hydrogen starting working for you on a daily basis!

hydrogen supplements Megahydrate

Dr. G. Patrick Flanagan’s Megahydrate (60 capsules).


Hydrogen Articles

Hydrogen for Optimal Health

Wonders of Molecular Hydrogen

Molecular Hydrogen (H2) at the Forefront of Health Research

The Science Behind MegaHydrate by Hank Liers, PhD

Hydrogen Products

Active H2 Ultra tablets

Vital Reaction tablets

Megahydrate capsules

Other Hydrogen Resources

Molecular Hydrogen Foundation

hydrogen supplements megahydrate active H2

Hydrogen supplements like Megahydrate and Active H2 are foundational in the HPDI supplement system.



Dr. Hank Liers, PhD H2 molecular hydrogen H2I have recently researched the healing potential and benefits of molecular hydrogen (H2). I am quite surprised to see many studies in the last 10 years regarding the healing abilities of H2. Below is an abstract of an article summarizing much of the research that has been carried out. The entire article is available when you click the link.

Molecular Hydrogen H2 water infusion


From: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3660246/

“Studies on molecular hydrogen have evolved tremendously from its humble beginnings and have continued to change throughout the years. Hydrogen is extremely unique since it has the capability to act at the cellular level. Hydrogen is qualified to cross the blood brain barrier, to enter the mitochondria, and even has the ability to translocate to the nucleus under certain conditions. Once in these ideal locations of the cell, previous studies have shown that hydrogen exerts antioxidant, anti-apoptotic, anti-inflammatory, and cytoprotective properties that are beneficial to the cell. Hydrogen is most commonly applied as a gas, water, saline, and can be applied in a variety of other mediums. There are also few side effects involving hydrogen, thus making hydrogen a perfect medical gas candidate for the convention of novel therapeutic strategies against cardiovascular, cerebrovascular, cancer, metabolic, and respiratory diseases and disorders. Although hydrogen appears to be faultless at times, there still are several deficiencies or snares that need to be investigated by future studies. This review article seeks to delve and comprehensively analyze the research and experiments that alludes to molecular hydrogen being a novel therapeutic treatment that medicine desperately needs.”


Also, I have recently become aware of the testimonials of people consuming H2 infused water with powerful results. Several people have reported a great diminution of joint pains, improved breathing, clearer thinking, and better sleep shortly after consuming the water.


I have been investigating products on the market that contain H2 and these include 1) Tablets producing H2 when dropped into water, 2) Bottles of water that contain H2, and 3) Water ionizers that produce considerable amounts of H2. One of the advantages of molecular hydrogen-infused water is that it is easy to consume it, and convenient to make it wherever and whenever you like.

HPDI now sells a tablet hydrogen product from Purative known as Active H2.

Active H2 is a unique, patent-pending combination of all-natural minerals used to generate molecular hydrogen and electron-rich potential (-ORP). This distinguishes it from existing hydrogen formulas and electrolysis (water ionizers).

Active H2 is easy to use. Simply place one tablet of in a 1/2 liter (16 oz) container of pure water (filled to the top) and close tightly. Wait at least 5–10 minutes for it to completely disintegrate (fizz), and then drink.

A one pint glass mason jar works well as a container for this purpose. However, you can use up to one liter (about 32 ounces) of water in a container, so a quart mason jar also works well. Consume the hydrogen-infused water preferably at least 30 minutes before food.

Active H2 formula consists of a proprietary blend of pure magnesium, malic acid, fumaric acid, and maltose that synergistically act to generate molecular hydrogen and electron-rich potential (-ORP).

Active H2 is the only all-natural add-in tablet providing molecular hydrogen in the amount of greater than 1.8 ppm, That is, one tablet typically generates molecular hydrogen in the concentration of about 2 ppm.

Please look for additional information about molecular hydrogen and Active H2 tablets in forthcoming HPDI blog articles.


by Fred Liers, PhD (from the HPDI Blog)

ACTIVE H2 (tablet product)

Molecular Hydrogen Foundation (MHF)


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