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HPDI FOUNDATIONAL SUPPLEMENTS – VIDEO

Fred Liers PhD foundational supplements nutritionDo you know HPDI has a foundational supplements system? And that HPDI’s system of Foundational Supplements is part of the comprehensive HPDI supplements system?

Foundational supplements are basic supplements providing essential nutrients that should be the “foundation” of everyone’s daily regimen. They are the foundation of a complete nutritional supplement program. They are the like the base of a pyramid in a complete nutritional supplement program.

All six HPDI foundational supplements are designed to provide a complete range of essential nutrients to complement a healthy diet and lifestyle. They help ensure sufficient levels of nutrients necessary for good health. And they are the first supplements we recommend taking as part of a complete nutritional supplement regimen.

Foundational supplements are the cornerstone in the HPDI supplement system. That is, HPDI offers a three-tiered system of nutritional supplements: Foundational Supplements, Enhancement Formulas, and Specific-Condition Formulas. The three “tiers” combined represent a complete nutritional supplement program. When customized appropriately to meet the needs of individuals, the three tiers of nutritional supplements help create optimal health.

You can visualize the HPDI supplement system as a cone or pyramid having a base of Foundational Supplements ascending toward an apex of Enhancement Formulas and Specific Condition Formulas.

foundational supplements HPDI system

The HPDI Supplement System includes six Foundational Supplements—four primary and two secondary—including multivitamins, vitamin C/antioxidants, essential fats, and Rejuvenate! superfoods.

HPDI FOUNDATIONAL SUPPLEMENTS

We recommend six basic types of foundational supplements. The six categories are: 1) multivitamin formulas, 2) vitamin C / antioxidant formulas, 3) essential fats, 4) high-RNA foods (Rejuvenate! superfoods), 5) gut health formulas, and 6) hydrogen formulas.

We further break down the six foundational supplements into “primary” and “secondary” foundational supplements. The first four (listed above) being primary and the last two (gut health and hydrogen formulas) being secondary. This doesn’t mean that gut health or hydrogen formulas are less essential, depending on the person. But typically we recommend the first four in order.

We established the original three types of foundational supplements about 1988. We have always recommended multivitamins, vitamin C and antioxidants, and essential fats, as being the most important nutritional supplements for establishing and maintaining general health.

We later added high-RNA foods (like Rejuvenate! superfoods) as a fourth type of foundational supplement because research indicates dietary nucleic acids are essential nutrients—see our many articles on dietary nucleic acids, Dr. Benjamin S. Frank, and about Rejuvenate! superfoods (Original Greens, PLUS, and Berries & Herbs).

Two categories of foundational supplements were added more recently: gut health formulas (especially Restore) and hydrogen formulas. Hank wrote an article (Amending the HPDI Foundational Program) about these changes in April 2016. We added these two categories after much consideration regarding their benefits, and have written extensively about them (see Resources below).

The entire HPDI supplement system is depicted (above) as a cone. The six types of foundational supplements form the base of the cone. Enhancement Formulas and Specific-Condition formulas sit above toward the apex.

ultimate protector foundational supplements

Ultimate Protector Nrf2 formula is a foundational supplement in the vitamin C / antioxidant category.

FOUNDATIONAL SUPPLEMENTS: BEST PRACTICES

I recommend using all six types of HPDI foundational supplements. I personally take the following supplements (below) and present them here as an example of how they can be integrated into a complete supplement regimen. Foundational Supplements I take:

1. Multivitamin: Hank & Brian’s Mighty Multi-Vite! (4 per day in divided doses)

2. Vitamin C / antioxidants: PRO-C (6–8 per day) and Ultimate Protector Nrf2 activator (8–12 per day)

3. Essential Fats: Essential Fats Plus E (4 per day)

4. Rejuvenate!™ superfood: All three Rejuvenate! superfoods (2–8 scoops per day)

5. Gut Health: RESTORE For Gut Health (1–2 ounces per day) and/or a soil-based probiotic (1–3 per week)

6. Hydrogen: Megahydrate (2–6 per day) and/or VR Tablets

Taking one supplement from each of the six foundational supplement categories helps build, support, and maintain optimal health.

We at HPDI recommend everyone take one of each type of foundational supplement. That is, we suggest an individual select for personal use a multivitamin, vitamin C/antioxidant formula, essential fats formula, Rejuvenate!™ superfood (or other high-RNA superfood), hydrogen product, and at least one gut health product (typically RESTORE) depending on their gut-health needs).

Likewise, we suggest health care professionals recommend for their clients one of each of the six types of foundational supplements.

The other two categories in the HPDI nutritional supplement system are Enhancement Formulas and Specific-Condition Formulas (see cone diagram). These are not foundational supplements. However, I include the supplements I take in these categories to show how Enhancement and Specific-Condition Formulas fully integrate with Foundational Supplements to form a complete supplement program providing not only essential nutrients required for health, but also particular nutrients required by me. This makes the system fully “customizable” to individual needs.

Enhancement Formulas I take include: B-Complex-50 (B complex), Myo-Mag (magnesium/malic acid), Ubiquinol-50, Bone Guardian, and Vitamin D3 Plus.

Specific Condition Formulas I take include: Joint Health Formula, Allergy Support Formula, Eye & Vision Formula, Intestinal Rejuvenation Formula, and Warrior Mist (pain topical), and Warrior Sleep (sleep topical).

Thus, I take supplements from all three categories (Foundationals, Enhancements, and Specific-Condition) in the HPDI supplement system. However, I always prioritize foundational supplements—I take them first—because they are the all-important “base” on which my personal supplement program rests.

Foundational supplements ideally are the base on which your supplement program—or those of your clients—rests, as well.

We have seen the results of taking a complete set of foundational supplements. They work because the nutrients they provide are needed by everyone.

foundational supplements multivitamin

Muti Two Caps is a high-potency multivitamin with advanced forms for optimal utilization in the body.

SYNERGY OF FOUNDATIONAL SUPPLEMENTS

Individuals who use all six types of foundational supplements do best in terms of optimizing health. The reason is that all six foundational supplements provide nutrients required for good health.

All six types of foundational supplement provide unique benefits. Yet, each performs functions required by the human body for good health. That is one reason when they are combined they exert synergistic effects for health going far beyond the benefits just using a few types of foundational supplements, depending on individual needs, of course.

A SYSTEM OF FOUNDATIONAL SUPPLEMENTS IS NECESSARY

Individuals benefit from a structured system of supplements that can be tailored to their needs. Otherwise basic nutrients may be left out from daily intake.

For example, I know people who may or may not take a multivitamin. And they may or may not take vitamin C. Yet, they may take calcium for their bones, glucosamine for their joints, and lutein for their eyes. Or they may take a low-potency multivitamin providing merely the RDA for all nutrients.

It is fine that individuals take supplements they regard as important or useful. But that does not guarantee that a wide range—and sufficient levels—of nutrients necessary for health are available to the body on a regular basis.

In fact, I regard the supplement intake programs of most persons to be “hit-or-miss.” They may consume nutrients important for a few functions in the body, yet fail to obtain other essential nutrients required for the nutrients they take to work most effectively. We have written extensively on this topic on our website and in blog articles (see below).

Not taking regularly a complete set of foundational supplements likely means key nutrients (and key levels of nutrients) go missing. Over time, this means fewer and lower levels of nutrients available to support the body’s needs for them at levels known to sustain the good health.

The best way to ensure a sufficient range of nutrients at plentiful levels is to take foundational supplements. After a baseline of nutrients is established by taking foundational supplements, additional supplements can be added, as necessary. Following such a system and using it to customize a personal supplement regimen means there is a far better opportunity to obtain essential nutrients on a daily basis. And not to miss nutrients that help create optimal health.

rejuvenate superfood foundational supplements

High-RNA foods like Rejuvenate! PLUS superfood provide dietary nucleic acids important for health.

A COMPLETE SUPPLEMENT SYSTEM INCLUDES FOUNDATIONAL SUPPLEMENTS

After obtaining sufficient levels of basic nutrients required for health, then a person can add (or you can recommend) specific nutrients or formulas that target certain problems or issues. This is the basis for HPDI’s creation of Enhancement Formulas and Specific-Condition Formulas.

Nutritional supplements in the categories of Enhancement Formulas and Specific-Condition Formulas “stack” on top of HPDI’s Foundational Supplements (see cone diagram above). In this way, a complete nutritional supplement program begins with the most essential nutrients and continues with customizations based on the unique needs of an individual.

ENHANCEMENT FORMULAS

Enhancement Formulas in the HPDI system are supplements we regard as falling into the next tier in terms of importance, at least for most people. They do not necessarily provide essential nutrients, and yet many people (including myself) benefit significantly from them.

Enhancement Formulas include: magnesium formulas (topical and capsule), Vitamin D3 Plus, Nascent Iodine, Vitamin B12 (methylcobalamin), mushroom-based products (like Immune-Assist™), Prolyt (proteolytic enzymes), Digase (plant-based enzymes), and Warrior Mist (topical pain reliever), and many other formulas.

SPECIFIC-CONDITION FORMULAS

In the HPDI system, individuals can add (in a modular way) various formulas and single nutrients designed to support a particular set of needs or a target a specific condition.

We offer a complete range of supplements (almost 100) including a range of supplements formulated to address specific conditions. These include Joint Health Formula, Eye & Vision Formula, Blood Sugar Support, Allergy Support, Prosta Plus, Intestinal Rejuvenation Formula, and many other formulas.

ONE SYSTEM. THREE TIERS. HPDI NUTRITIONAL SUPPLEMENTS.

HPDI Foundational Supplements collectively form the base tier of a complete nutritional supplement system comprised of three tiers: 1) Foundational Supplements (six types), 2) Enhancement Formulas (or simply “Enhancements”), and 3) Specific-Condition Formulas.

Foundational Supplements are necessary because they provide nutrients foundational to health. Taking them daily or recommending your clients take them daily can help mean big differences in health, nutrition, and quality of life.

We at HPDI design our nutritional supplements to be the most effective dietary supplements available. HPDI products are known for: 1) Advanced Formulation (including use of superior forms of nutrients), 2) Ultra-High Purity, 3) Avoidance of Harmful Ingredients, and 4) being made with Good Manufacturing Practices (GMP). For more details, please see The HPDI Difference and our Statement on Additives (Excipients).

At least 40 of HPDI’s products are formulated by Dr. Hank Liers. They fall in all categories in HPDI’s supplement system. They can be found under “Dr. Hank Liers original formulas.”

foundational supplement EFA

Essential Fats Plus E provides well-balanced omega-3 and omega-6 fatty acids.

ADDENDUM: THE BODYSYNC GENETIC TEST & ACTION PLAN

In recent years, genetic tests have become available that show gene variations can cause or predispose a person to serious conditions relating to important body functions such a lessened ability to process synthetic B vitamins (like folic acid), higher blood glucose levels, lower immune system function, and bone density problems relating to variants in the vitamin D receptor (VDR) gene, for example.

We recommend a genetic test to determine whether individuals have certain gene variations impacting health. HPDI has teamed with a genetic testing company (BodySync, Inc.) and sells BodySync test kits on our Reseller site. To read about the BodySync genetic test and test kits click here. Genes tested for in the Bodysync test include variations in genes impacting folate assimilation, cardiovascular health, detoxification, bone health, and more. Resellers can purchase the test kits directly from HPDI and retail customers can call us (800-228-4265) to find out how we can help them get a test kit and support them with any associated counseling regarding the results.

Genetic testing allows individuals to gain a clearer picture of where they may require additional or specific nutritional supplementation. In this respect, HPDI foundational supplements can play a significant role in providing the amounts and range of important nutrients that can help mitigate the adverse effects of certain gene variations in addition to diet, exercise, and lifestyle factors. After testing, you will receive a Bodysync Action Plan that makes recommendations for a healthy diet and lifestyle customized to your unique genetic profile.

FOUNDATIONAL SUPPLEMENTS: FREQUENTLY ASKED QUESTIONS (FAQ)

We frequently get questions from HPDI clients and resellers regarding foundational supplements. These questions include:

“Why did you add gut health and hydrogen products to your foundational supplements program?”
We found it necessary to add categories for gut health and hydrogen because they provide nutrients that are support the body and help ensure the foundational supplement system supports health most effectively. You can read more in previous blog articles (see below).

“Which is the better multivitamin: Multi Two or Mighty Multi-Vite!™?”
It depends on whether you need more B vitamins or antioxidants. Multi Two provides more B vitamins and Mighty Multi-Vite™ provides more antioxidants and cofactors. I take a separate HPDI B-Complex-50 formula, so I take Mighty Multi-Vite!™ as my primary multivitamin.

“What are the differences between Rejuvenate!™ Original, PLUS, and Berries & Herbs superfoods?”
They each provide about 340 mg of dietary nucleic acids. Original is the “greenest” with a large percentage of dietary nucleic acids coming from chlorella and spirunlina. PLUS is our most popular and 30% is identical to Original with more protein and a built-in multivitamin complex. Berries & Herbs contains no greens, yet more nucleic acids (390 mg), protein, and a built-in multivitamin. See our Rejuvenate! comparison page for more information.

“Should I take a vitamin C formula with antioxidants like PRO-C or one with Nrf2 activators like Ultimate Protector?”
Both provide vitamin C and Nrf2 activators, but Ultimate Protector provides more types of Nrf2 activators. Ultimate Protector capsules are smaller than PRO-C capsules, so a daily dose may require taking more capsules.

“How important are hydrogen supplements?”
Very important for energy production, recovery, antioxidant functions, and gut health. Hydrogen supplements like VR Tablets and Megahydrate ensure high levels of hydrogen are available in the body.

What are your best products for supporting gut health?
It depends on your needs: cleansing (Intestinal Rejuvenation Formula), probiotic/microbiome support, or tightening tight junctions in the gut (RESTORE)? We offer products for all these purposes. Typically, the first gut health formula we recommend is RESTORE because so many people require extra support for microbiome health and to restore gut integrity.

These are just a few questions frequently asked about HPDI foundational supplements. If you need more information about products, please contact the HPDI office (800-228-4265) or email support@healthproductsdistributors.com.

You can also contact Fred Liers, PhD or Hank Liers, PhD (formulator) with questions you may have regarding specific products, single nutrients, or formulation.

SOURCES AND RESOURCES

Foundational Supplements

HPDI Full Product Overview

The Need for Foundational Supplements (.pdf)

The HPDI Difference (4 Pillars of Formulation)

HPDI BLOG ARTICLES

Amending the HPDI Foundational Supplements Program

Foundational Supplements Remain Fundamental

Vitamin C / Antioxidants

PRO-C and Ultimate Protector Comparison

Questions and Answers about Ultimate Protector

The Amazing Healing Potential of Natural Nrf2 Activators

Ultimate Protector™: First Impressions

Ultimate Protector™ Brunswick Labs ORAC5.0™ Test Results

Preventing Free-Radical Damage Using Ultimate Protector™

Description and Comparison of ORAC Tests for Well Known Plant Ingredients and Ultimate Protector™

Ultimate Protector and the Role of Foundational Supplements for Health

Natural Phytochemical Nrf2 Activators for Chemoprevention

New Directions for Preventing Free Radical Damage

Review of Scientific Research on Oligomeric Proanthocyanidins (OPC)” by Dr. Hank Liers

“Vitamin C – An Amazing Nutrient” by Dr. Hank Liers

High-RNA Superfoods

Rejuvenate! Berries & Herbs: Ingredients for Optimal Nutrition

“9 Things to Know About Rejuvenate!™ Superfoods”

“High-RNA Rejuvenate!™ Superfood”

“Natural Phytochemical NRF2 Activators for Chemoprevention”

Review of Scientific Research on Oligomeric Proanthocyanidins (OPC)

DIETARY NUCLEIC ACIDS – DR. BENJAMIN S. FRANK, PART 1

DIETARY NUCLEIC ACIDS – DR. BENJAMIN S. FRANK, PART 2

Super-Tasty Morning Nutritional Drinks

Hydrogen

The Science Behind Megahydrate

Hydrogen for Optimal Health

Wonders of Molecular Hydrogen

Gut Health

Gut Health – Effects of Glyphosate and Antibiotics

Gut Health – Intestinal Rejuvenation Formula

PRODUCTS

Vitamin formulas, including multivitamins

Rejuvenate!™ Berries & Herbs

Rejuvenate!™ PLUS

Rejuvenate!™ (Original)

Rejuvenate! Superfoods: Product Comparison

Ultimate Protector™ Nrf2 Activator (vitamin C/antioxidant)

PRO-C™ (Vitamin C/Antioxidant formula)

Essential Fats Plus E

Intestinal Rejuvenation Formula (gut health)

Restore For Gut Health (lignite formula)

Active H2 (hydrogen)

Megahydrate (hydrogen)

VR Tablets (hydrogen)

Prescript-Assist™ (probiotic/prebiotic)

HPDI FOUNDATIONAL SUPPLEMENTS

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USING HPDI FOUNDATIONAL SUPPLEMENTS

Fred Liers PhD foundational supplements nutritionHPDI foundational supplements are designed to provide a complete range of essential nutrients that complement a healthy diet and lifestyle. They help ensure sufficient levels of nutrients required for good health.

We define foundational supplements as basic or “core” supplements that should be part of everyone’s daily regimen. They are the foundation of a complete nutritional supplement program.

HPDI has a three-tiered system of nutritional supplements: 1) Foundational Supplements, 2) Enhancement Formulas, and 3) Specific-Condition Formulas. All three tiers comprise a complete nutritional supplement program.

When properly combined, these three tiers of nutritional supplements help create optimal health. This month, I explain how to use HPDI foundational supplements, the base or bottom tier of the system (see cone diagram below).

The HPDI supplement system can be visualized as a cone having a base of Foundational Supplements ascending toward an apex of Enhancement Formulas and Specific Condition Formulas.

foundational supplements HPDI system

The HPDI Supplement System includes six types of Foundational Supplements forming its base.

USING HPDI FOUNDATIONAL SUPPLEMENTS

My intent is to guide consumers and health care professionals to decide the foundational supplements that are best for their purposes, and that provide the most effective results.

For anyone new to HPDI’s Foundational Supplements system, we recommend six basic types of supplements. The six categories are: 1) multivitamin formulas, 2) vitamin C / antioxidant formulas, 3) essential fats, 4) high-RNA foods (Rejuvenate! superfoods), 5) gut health formulas, and 6) hydrogen formulas.

We established the original three types of foundational supplements about 1988. We have always suggested that clients and health professionals take and/or recommend multivitamins, vitamin C and antioxidants, and essential fats.

About 10 years ago, we added high-RNA foods (like Rejuvenate! superfoods) as a fourth type of foundational supplement because research indicates dietary nucleic acids are essential nutrients—see our blog articles on nucleic acids, Benjamin S. Frank, MD, PhD, and about Rejuvenate! superfoods (Original, Plus, and Berries & Herbs).

Two categories of foundational supplements are new: gut health formulas and hydrogen formulas. Hank wrote an article (Amending the HPDI Foundational Program) about these changes in April. We added these two categories after much consideration regarding their benefits, and have written extensively about them in this blog (see resources section below).

The entire HPDI supplement system is depicted (above) as a cone. The six types of foundational supplements form the base of the cone. Enhancement Formulas and Specific-Condition formulas sit above toward the apex.

ultimate protector foundational supplements

Ultimate Protector Nrf2 formula is a foundational supplement in the vitamin C / antioxidant category.

HOW I USE HPDI FOUNDATIONAL SUPPLEMENTS

I use all six types of HPDI foundational supplements. I take the following supplements (below) and present them here as an example of how they can be integrated into a complete supplement regimen. Foundational Supplements I take:

1. Multivitamin: Hank & Brian’s Mighty Multi-Vite! (4 per day in divided doses)

2. Vitamin C / antioxidants: PRO-C (6-8 per day) and Ultimate Protector Nrf2 activator (8-12 per day)

3. Essential Fats: Essential Fats Plus E (4 per day)

4. Rejuvenate!™ superfood: All three Rejuvenate! superfoods (2-8 scoops per day)

5. Gut Health: RESTORE For Gut Health (1-2 ounces per day) and Prescript-Assist™ probiotic (soil-based organisms) (1-3 per week)

6. Hydrogen: Megahydrate (2-6 per day)

Taking one supplement from each of the six foundational supplement categories builds, supports, and maintains optimal health.

We at HPDI recommend everyone take one of each type of foundational supplement. That is, we suggest an individual select for personal use a multivitamin, vitamin C/antioxidant formula, essential fats formula, Rejuvenate!™ superfood (or other high-RNA superfood), hydrogen product, and at least one gut health product (depending on their gut-health needs).

Similarly we suggest health care professionals recommend for their clients one of each of the six types of foundational supplements.

The other two categories in the HPDI nutritional supplement system are Enhancement Formulas and Specific-Condition Formulas (see cone diagram). These are not foundational supplements. However, I include the supplements I take in these categories for the sake of completeness, as well as to show how Enhancement and Specific-Condition Formulas integrate with Foundational Supplements to form a complete supplement program providing a wide-range of essential nutrients required for health.

Enhancement Formulas I take include: B-Complex-50 (B complex), Myo-Mag (magnesium/malic acid), Ubiquinol-50, Bone Guardian, and Vitamin D3 Plus.

Specific Condition Formulas I take include: Joint Health Formula, Allergy Support Formula, Eye & Vision Formula, Intestinal Rejuvenation Formula, and Warrior Mist (pain topical), and Warrior Sleep (sleep topical).

While I take supplements from all three categories (Foundationals, Enhancements, and Specific-Condition) in the HPDI supplement system, I always prioritize foundational supplements—I take them first—because they are base on which my personal supplement program rests.

Foundational supplements should be the base on which your supplement program—or those of your clients—rests, as well.

We have seen the results of taking a complete set of foundational supplements. They work because the nutrients they provide are needed by everyone.

HPDI foundational supplements multivitamin

Muti Two Caps is a high-potency multi with coenzyme forms for optimal utilization in the body.

FOUNDATIONAL SUPPLEMENTS: RESULTS

Individuals who take all types of foundational supplements do best in terms of optimizing health. The reason is that all six types provide nutrients required for good health.

I can attest that HPDI Foundational Supplements are effective for improving or maintaining good health. In addition, I have witnessed numerous instances where individuals benefit most greatly when taking all four–and now all six–types of foundational supplements.

Each of the six categories of foundational supplement provide unique benefits. Yet, each performs functions required by the human body for good health. That is one reason when they are combined they exert synergistic effects for health going far beyond the benefits of using, one, two, or three of the types of foundational supplements.

WHEN FOUNDATIONAL SUPPLEMENTS ARE NOT PRIORITIZED

I talk to people who may or may not take a multivitamin. And they may or may not take vitamin C. Yet, they may take calcium for their bones, glucosamine for their joints, and lutein for their eyes. Or they may take a low-potency, off-the-shelf multivitamin providing merely the RDA for all nutrients.

There is nothing wrong with individuals taking supplements they regard as important or useful. But that cannot guarantee that a wide range—and sufficient levels—of nutrients necessary for health are available to the body on a regular basis.

In fact, I regard the supplement intake programs of most persons to be “hit-or-miss.” They may consume nutrients important for a few functions in the body, yet fail to obtain other essential nutrients required for the nutrients they take to work most effectively. We have written extensively on this topic on our website and in blog articles (see below).

Not taking regularly a complete set of foundational supplements likely means key nutrients (and key levels of nutrients) go missing. Over time, this means fewer and lower levels of nutrients available to support the body’s needs for them at levels known to sustain the good health.

The best way to ensure a sufficient range of nutrients at plentiful levels is to take foundational supplements. After a baseline of nutrients is established by taking foundational supplements, additional supplements can be added, as necessary.

rejuvenate superfood foundational supplements

High-RNA foods like Rejuvenate! PLUS superfood provide dietary nucleic acids important for health.

A COMPLETE SYSTEM OF SUPPLEMENTS, INCLUDING FOUNDATIONALS

After obtaining sufficient levels of basic nutrients required for health, then a person can add (or you can recommend) specific nutrients or formulas that target certain problems or issues. This is the basis for HPDI development of Enhancement Formulas and Specific-Condition Formulas.

Nutritional supplements in the categories of Enhancement Formulas and Specific-Condition Formulas therefore “stack” on top of HPDI’s Foundational Supplements (see cone diagram above). In this way, a complete nutritional supplement program begins with the most essential nutrients and continues with customizations based on the unique needs of an individual.

ENHANCEMENT FORMULAS

Enhancement Formulas in the HPDI system are supplements we regard as falling into the next tier in terms of importance, at least for most people. They do not necessarily provide essential nutrients, and yet many people (including myself) benefit significantly from them.

Enhancement Formulas include: magnesium formulas (topical and capsule), Vitamin D3 Plus, Nascent Iodine, Vitamin B12 (methylcobalamin), mushroom-based products (like Immune-Assist™), Prolyt (proteolytic enzymes), Digase (plant-based enzymes), and Warrior Mist (topical pain reliever), and many other formulas.

SPECIFIC-CONDITION FORMULAS

In the HPDI system, individuals can add (in a modular way) various formulas and single nutrients designed to support a particular set of needs or a target a specific condition.

We offer a complete range of supplements (almost 100) including a range of supplements formulated to address specific conditions. These include Joint Health Formula, Eye & Vision Formula, Blood Sugar Support, Allergy Support Plus, Prosta Plus, and many other formulas.

ONE SYSTEM. THREE TIERS. HPDI SUPPLEMENTS.

HPDI Foundational Supplements collectively form the base tier of a complete nutritional supplement system comprised of three tiers: 1) Foundational Supplements (six types), 2) Enhancement Formulas (or simply “Enhancements”), and 3) Specific-Condition Formulas.

Foundational Supplements are necessary because they provide nutrients foundational to health. Taking them daily or recommending your clients take them daily can help mean big differences in health, nutrition, and quality of life.

We at HPDI design our nutritional supplements to be the most effective dietary supplements available. HPDI products are known for: 1) Advanced Formulation (including use of superior forms of nutrients), 2) Ultra-High Purity, 3) Avoidance of Harmful Ingredients, and 4) being made with Good Manufacturing Practices (GMP). For more details, please see The HPDI Difference and our Statement on Additives (Excipients).

At least 40 of HPDI’s products are formulated by Dr. Hank Liers. They fall in all categories in HPDI’s supplement system. They can be found under “Dr. Hank Liers original formulas.”

omega plus foundational supplement

Omega Plus provides exceptionally well-balanced omega-3 and omega-6 fatty acids.

FOUNDATIONAL SUPPLEMENTS: FREQUENTLY ASKED QUESTIONS (FAQ)

We frequently get questions from HPDI clients and resellers regarding foundational supplements. These questions include:

“Why did you add gut health and hydrogen products to your foundational supplements program?”
We found it necessary to add categories for gut health and hydrogen because they provide nutrients that are support the body and help ensure the foundational supplement system supports health most effectively. You can read more in previous blog articles (see below).

“Which is the better multivitamin: Multi Two or Mighty Multi-Vite!™?”
It depends on whether you need more B vitamins or antioxidants. Multi Two provides more B vitamins and Mighty Multi-Vite™ provides more antioxidants and cofactors. I take a separate HPDI B-Complex-50 formula, so I take Mighty Multi-Vite!™ as my primary multivitamin.

“What are the differences between Rejuvenate!™ Original, PLUS, and Berries & Herbs superfoods?”
They each provide about 340 mg of dietary nucleic acids. Original is the “greenest” with a large percentage of dietary nucleic acids coming from chlorella and spirunlina. PLUS is our most popular and 30% is identical to Original with more protein and a built-in multivitamin complex. Berries & Herbs contains no greens, yet more nucleic acids (390 mg), protein, and a built-in multivitamin. See our Rejuvenate! comparison page for more information.

“Should I take a vitamin C formula with antioxidants like PRO-C or one with Nrf2 activators like Ultimate Protector?”
Both provide vitamin C and Nrf2 activators, but Ultimate Protector provides more types of Nrf2 activators. Ultimate Protector capsules are smaller than PRO-C capsules, so a daily dose may require taking more capsules.

“How important are hydrogen supplements?”
Very important for energy production, recovery, antioxidant functions, and gut health. Hydrogen supplements like Active H2 and Megahydrate ensure high levels of hydrogen are available in the body.

What are your best products for supporting gut health?
It depends on your needs: cleansing (Intestinal Rejuvenation Formula), probiotic/microbiome support (Prescript-Assist™), or tightening tight junctions in the gut (RESTORE)? We offer products for all these purposes.

These are just a few questions frequently asked about HPDI foundational supplements. If you need more information about products, please contact the HPDI office (800-228-4265) or email support@healthproductsdistributors.com.

You can also contact Fred Liers, PhD (520-400-0155) or Hank Liers, PhD (formulator) with questions you may have regarding products, ingredients, or formulation.

SOURCES AND RESOURCES

Foundational Supplements

HPDI Full Product Overview

The Need for Foundational Supplements (.pdf)

The HPDI Difference (4 Pillars of Formulation)

HPDI BLOG ARTICLES

Amending the HPDI Foundational Supplements Program

Foundational Supplements Remain Fundamental

Vitamin C / Antioxidants

PRO-C and Ultimate Protector Comparison

Questions and Answers about Ultimate Protector

The Amazing Healing Potential of Natural Nrf2 Activators

Ultimate Protector™: First Impressions

Ultimate Protector™ Brunswick Labs ORAC5.0™ Test Results

Preventing Free-Radical Damage Using Ultimate Protector™

Description and Comparison of ORAC Tests for Well Known Plant Ingredients and Ultimate Protector™

Ultimate Protector and the Role of Foundational Supplements for Health

Natural Phytochemical Nrf2 Activators for Chemoprevention

New Directions for Preventing Free Radical Damage

Review of Scientific Research on Oligomeric Proanthocyanidins (OPC)” by Dr. Hank Liers

“Vitamin C – An Amazing Nutrient” by Dr. Hank Liers

Rejuvenate! Superfoods

Rejuvenate! Berries & Herbs: Ingredients for Optimal Nutrition

9 Things to Know About Rejuvenate!™ Superfoods

High-RNA Rejuvenate!™ Superfood

Get Results with Rejuvenate! Superfoods

Dietary RNA for Athletic Performance

DIETARY NUCLEIC ACIDS – DR. BENJAMIN S. FRANK, PART 1

DIETARY NUCLEIC ACIDS – DR. BENJAMIN S. FRANK, PART 2

Super-Tasty Morning Nutritional Drinks

Hydrogen

The Science Behind Megahydrate

Hydrogen for Optimal Health

Wonders of Molecular Hydrogen

Gut Health

Gut Health – Effects of Glyphosate and Antibiotics

Gut Health – Intestinal Rejuvenation Formula

PRODUCTS

Vitamin formulas, including multivitamins

Mighty Multi-Vite!

Multi Two Caps

Rejuvenate!™ Berries & Herbs

Rejuvenate!™ PLUS

Rejuvenate!™ (Original)

Rejuvenate! Superfoods: Product Comparison

Ultimate Protector™ Nrf2 Activator (vitamin C/antioxidant)

PRO-C (Vitamin C/Antioxidant formula)

Intestinal Rejuvenation Formula (gut health)

Restore For Gut Health (lignite formula)

Active H2 (hydrogen)

Megahydrate (hydrogen)

Prescript-Assist™ (probiotic/prebiotic)

HPDI FOUNDATIONAL SUPPLEMENTS

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FOUNDATIONAL SUPPLEMENTS REMAIN FUNDAMENTAL

Fred Liers PhD foundational supplements remain fundamentalI spoke with an old friend recently. I will call him Joe.

Joe has digestive tract issues, including extreme diverticulosis. While I have provided him with suggestions for improved nutrition and supplement use in recent years, he hasn’t followed any of my recommendations seriously.

Instead Joe opted for a more conventional route. Now his situation has worsened dramatically, and he says he’s ready to start a program of improved nutrition and supplements. That’s good, even though it would be easier had he started sooner. Like I said, Joe is a good friend. I wish him health and happiness.

My initial advice to Joe remains the same as it would be for everyone. He should start with a dietary changes and a solid program of foundational supplements like those in the HPDI Foundational Supplements Program. He can later add enhancements and condition-specific formulas addressing his unique needs.

WHY FOUNDATIONAL SUPPLEMENTS?

The HPDI Foundational Supplements program was developed by Hank Liers, PhD to provide optimal levels of basic nutrients important for good health. In our experience, the HPDI program works to support vibrant health. It also helps cover gaps left by poor diet, incomplete nutritional supplementation, and imbalances due to genetic factors. It helps to compensate for lower nutrients levels found in many modern foods both processed and/or produced by modern industrial agricultural methods (i.e., that deplete soils or block nutrient uptake).

Read more the HPDI Foundational Supplements Program.

6-types-supplements-foundation

HPDI’s foundational supplements program includes six categories of dietary supplements.

JOE’S DIET IS NOT SO GOOD

I don’t like to be overly prescriptive about food. But Joe is a “carb” lover and with a history of consuming processed, high-sugar foods, and junk foods. For example, processed breads, donuts, candy bars, and soda have been staples for years. It doesn’t help many of these foods either are GMO or high in glyphosate (the main ingredient in the herbicide RoundUp), which is known to produce adverse gastrointestinal (and other harmful) effects.

He has reduced his intake of high-carb, sugary foods in recent years. In fact, he has significantly cut back on simple sugars because he finds they drain his energy and don’t help his digestion.

I suggested he continue cutting back on simple carbs and sugars, and that he add more fresh vegetables and high-quality proteins to his diet. I recommend organically grown and non-GMO foods.

I can’t say what caused Joe’s diverticulosis. But I can say that changes in his diet are necessary to support optimal health, as well as healing of damage to his digestive tract.

It doesn’t help that Joe takes several drugs, including a long-term antibiotic for a stubborn urinary tract infection, and a laxative (containing polyethylene glycol) for his constipation and diverticulosis. These drugs may help in the short term, but they far from ideal for long-term use.

Joe himself isn’t pleased with his need for drugs. He intends ultimately to stop them when possible.

He has been having trouble sleeping in recent years. I suspect this may be related to his troubles with his intestinal tract, dysbiosis, and possibly issues with his microbiome.

SUPPLEMENTATION

Joe sent me his supplement schedule and results from a few health tests to review. He has “nutrition-oriented” doctors whose advice he follows quite rigorously.

I reviewed his supplement schedule and health test results. His results include some in-depth genetic tests, which provide insights into potential health concerns, and practical advice for nutritional supplementation.

IMBALANCES CALL FOR FOUNDATIONAL NUTRITION

I saw glaring gaps in Joe’s supplement schedule. There are major imbalances in his supplement program. For example, I see no multivitamins or vitamin C/antioxidant formula, which are basic to the HPDI foundational program.

Indeed, for all the good elements, his program unfortunately is hit-or-miss in terms of providing a complete spectrum of essential nutrients.

On the upside, he’s been taking a few specific-nutrient supplements daily:

5,000 mg of vitamin D (25-hydroxy).

3,000 mg of Omega-3 (EPA/DHA) and 1,000 mg of flax seed oil.

He gets some coenzyme B vitamins:

2,000 mcg of a methyl folate (MTHF)

1,000 mcg of B12 as methylcobalamin daily.

Taking these standalone coenzyme B vitamins is good because test results indicate he has the heterozygous genotype for the MTHFR C677T (C/T) and MTHFR A1298C (A/C). The presence of both polymorphisms can result in significantly reduced activity of MTHFR potentially leading to reduced production of the active form of folate (L-methylfolate).

As his test results stated: “Reduced levels of L-methylfolate lead to decreased production of neurotransmitters, reduced conversion of homocysteine to methionine, and reduced s-adenosylmethionie (SAMe) concentrations.”

GAPS: HIT OR MISS ON FOUNDATIONALS

I asked about his multivitamin and vitamin C intake. He said he takes them despite the fact they are absent from his supplement schedule. I supposed they were absent from his schedule because his doctors want to make sure he gets his vitamin D, folate, methylcobalamin, and essential fats, but aren’t too concerned about whether or not he takes a complete multivitamin, vitamin C/antioxidant formula, or complete B-complex vitamins.

Joe told me he takes a multivitamin, B-complex, and vitamin C supplement. But didn’t take all of them daily.  All three products came from a “big-box” store known for low prices.

Joe therefore consumed a few specific, advanced, medical-quality formulas at the direction of his doctors. Yet, he purchased low-end multivitamin, vitamin C, and B-complex products that can or should be the foundation of his supplement program.

His multivitamin was a low-potency formula providing only 3–500% of the daily value for most nutrients with many at exactly 100%. Not only is this multivitamin low-potency, but its forms are conventional (no coenzyme vitamins or advanced forms). Moreover, it is full of unnecessary additives and fillers like polyethylene glycol, polyvinylpyrrolidone, and sodium benzoate.

His vitamin C was 500 mg. He didn’t take it every day and when he did, he took only one or two.

WHAT I DID FOR JOE

Joe and I talked about his situation. He agreed to receive a package of supplements. Actually, I attempted several years ago to help him get onto a foundational supplements program. He took some supplements and he definitely noticed a difference in how he felt. Yet, he wasn’t ready to take a complete system of high-quality supplements. He finally agreed to try the program.

I sent him a package of HPDI supplements. It included two foundational supplements: Hank & Brian’s Mighty Multi-Vite! (multivitamin) and PRO-C (vitamin C/antioxidant formula). I did not include essential fats because he already takes them. I will send Rejuvenate! PLUS superfood and Intestinal Rejuvenation Formula in a separate shipment.

Joe now takes the Mighty Multi-Vite! and PRO-C, as well as Myo-Mag (magnesium) daily. He is already noticing he needs less of his laxative, and has scaled back his dosage. He can see the day is coming when he can wean himself entirely of it. He has updated his supplement schedule to include all of his supplements, so he can better track his supplement intake and ensure consistency.

I also sent him a Warrior Sleep for his sleeping troubles, and a bottle of Restore, which may help his intestinal tract and problems related to it.

PRO-C foundational supplements vitamin c

PRO-C is one of HPDI’s premier vitamin C / antioxidant formulas.

In forthcoming blog posts I plan to document the status of Joe’s health, including his energy levels and subjective feelings about his health. We will see how foundational supplements help him.

Not everyone is as fortunate as as Joe to have a friend who will send supplements and more importantly, talk to him in depth about nutrition and the need for foundational supplements.

WHAT JOE CAN DO FOR HIMSELF

It is my hope that Joe will follow the foundational supplements program, regain some health, and continue to improve by remaining on the program with HPDI supplements. He can take on his foundational supplements program as a mission for his own long-term health.

I also hope Joe’s experience with HPDI supplements will be an example to others who may be in similar situations. This includes individuals who don’t know where to begin, and those who take a variety of supplements yet aren’t receiving a full complement of essential nutrients.

Others who may be in similar situations to Joe’s include those who take supplements as directed by their doctor, but whose supplement schedule is “hit-or-miss,” which I suspect is a lot of people. Or those taking low-potency multivitamins or B-complex vitamins or just 500 mg of vitamin C daily. Also those taking basic supplements sporadically or whenever they “feel like it.”

Joe is far from being alone in having significant gaps in his foundation of essential nutrients that support good health. His doctors missed those gaps despite their best intentions to provide him with advanced nutrients based on genetic testing to assess potential deficiencies. “Losing sight of the forest for the trees” can happen to the best of us. In fact, the average person’s nutrient profile is not unlike Joe’s in many respects. And like Joe’s situation, foundational supplements can help close the gaps.

FOUNDATIONAL SUPPLEMENTS CAN LEAD TO BETTER HEALTH

There are many reasons I feel confident that HPDI foundational supplements will continue helping Joe. Not only am I not surprised he is noticing results, but also I’ve seen health improve in many (perhaps hundreds of) individuals when they begin a complete foundational supplements program, and then especially when they maintain it.

Good results are not surprising when the levels of nutrients increase from just 100% of the daily value for most nutrients to much higher levels.

Results improve over time when the body continues receiving high levels of essential nutrients.

Dietary supplements are generally non-toxic so there is little risk of problems when the body receives more than adequate nutrients to meet its needs.

And why take just the minimum? Minimum amounts of nutrients tend to perpetuate deficiencies when you consider factors like poor diet, increased oxidative stress, toxic exposures (leading to greater nutrient needs to support detoxification), and genetic factors (e.g., enzyme deficiencies).

multivitamins HPDI foundational supplements

HPDI Multivitamins include Mighty Multi-Vite!, Multi Two (caps and tabs), Mini Multi, and Chewable Kids Mighty-Multi!

HPDI FOUNDATIONAL SUPPLEMENTS PROGRAM

The HPDI Foundational Supplements Program until recently consisted of four types of supplement:

• High-Potency Multivitamin

• Vitamin C / Antioxidant Formulas

• Essential Fatty Acids

• High-RNA Superfoods (providing dietary nucleic acids)

Just last month, HPDI revised the Foundational Supplements Program to include two additional types of supplements:

• Gut Health formulas (such as Restore)

• Hydrogen products (such as Megahydrate and Active H2)

For more information on the revised system, see Amending the HPDI Foundational Supplements Program (blog post) by Hank Liers, PhD.

All six of these types of formulas comprise the HPDI Foundational Supplements Program. It is our belief that these six types of formulas are foundational to health regardless of whether you use HPDI’s supplements or those of another company (as long as they are high-quality, high-potency, provide the proper forms, and do not contain unnecessary excipients or toxic ingredients).

The HPDI foundational supplement program is the result of many years of product formulation, evaluating scientific research, following the experience of end-users, feedback from doctors and other clients, and staying on the cutting-edge of nutritional science. HPDI is known for updating its formulas as new information becomes available regarding better forms of nutrients, or means form improving nutrient uptake or utilization.

HPDI FOUNDATIONAL SUPPLEMENTS

HPDI formulates four of the six types of formulas in the Foundational Supplements Program.

HPDI Multivitamins include: Hank & Brian’s Mighty Multi-Vite!, Multi Two (caps or tabs), Mini Multi (for the chemically sensitive), and the Kid’s Mighty Multi!

HPDI Vitamin C / Antioxidant formulas include: PRO-C, Ultimate Protector Nrf2 formula, Buffered C (tabs), and Buffered C (powder)

HPDI Essential Fatty Acids: Essential Fats Plus E

HPDI’s Rejuvenate! Superfoods include: Rejuvenate! Original (densely green), Rejuvenate! PLUS (lightly green), and Rejuvenate! Berries & Herbs (no greens). See the Rejuvenate! side-by-side comparison.

HPDI foundational supplements are formulated by Dr. Hank Liers, PhD. Hank is known for formulas that utilize only the highest-purity and highest-quality ingredients, and for his emphasis on natural forms (e.g., coenzyme forms) best recognized and utilized by the body.

FOUNDATIONAL SUPPLEMENTS ARE FUNDAMENTAL

Foundational supplements are the foundation for good health. That is why we call them foundational. This is also why we believe so strongly in providing a strong foundation of nutrients before recommending what we call enhancement formulas, specific-condition formulas, or other add-ons (such as a soil-based probiotic formula).

That is to say, a given individual will possibly have many requirements for nutrients specific to their needs. Such formulas may include magnesium, iodine, certain B vitamins like coenzyme folate (5-MTHF). An individual may also require formulas specific to certain issues, concerns, or organ systems, such as formulas targeting joint health, bone health, allergies, blood sugar, liver health, and others. In fact, HPDI formulates formulas specific to these needs.

Yet, before specific needs are addressed, or at least concurrently, HPDI believes that foundational nutrients must provide the base or foundation upon which all other nutrients, condition-specific formulas, or enhancement formulas rest.

One danger, as we saw with Joe’s supplement schedule before he started taking HPDI foundational supplements, was putting the cart before the horse. That is, finding a person in a situation where there are several or numerous advanced nutrients being taken. Yet, where the “base” is relatively weak due to low-potency supplements and/or lack of basic nutrients. In this type of situation, it is less likely that the addition of several advanced nutrients can make as much of a difference for health because key nutrients are missing.

Missing key nutrients prevents certain advanced nutrients or even higher levels of specific nutrients from doing their job because major imbalances can render those nutrients useless, less bioavailable, or unable to contribute what they could were there a sufficiency of the basic nutrients required to support all biochemical processes in the body. We have written much on this topic—please see the resources section (below) for more information.

The point is that without a plentiful supply of basic nutrients in ideal forms, which is exactly what is provided by foundational supplements (and almost never by diet alone), a person will remain vulnerable to many nutrient deficiencies. Nutrient deficiencies (especially when they are prolonged over time) can result in less than optimal health.

By simply providing optimal levels of all basic nutrients, foundational supplements support the body by covering its nutritional needs, not unlike insurance. Moreover, they are generally inexpensive (relative to conventional health care costs) even for the highest-quality supplements, such as HPDI formulas.

CONCLUSION

Foundational supplements remain fundamental for health. Nothing can replace them. Before starting single nutrients or condition-specific formulas, it is important to obtain a full complement of basic nutrients that support bodily function.

After basic nutrition is attained through foundational supplements, diet, and appropriate lifestyle changes, then other types of nutritional supplements (such as enhancement formulas and specific-condition formulas) may be added to form a complete nutritional supplement system.

Key Takeaways:

• More people are getting advanced forms of specific vitamins and minerals in supplement form, usually at the direction of their doctor or nutritionist

• Few people obtain a complete, high-potency multivitamin

• Fewer still consume high-quality forms of all basic nutrients (provided by good diet and foundational supplements)

• Adding a complete set of high-potency, foundational supplements (multivitamin, Vitamin C / antioxidant formula, essential fats, high-RNA superfoods), hydrogen, and gut health formulas) supports basic good health

• Poor dietary choices increase the need for nutritional supplements that can provide high levels of a wide range of essential nutrients

• Taking foundational supplements sporadically is not a good way to ensure you obtain adequate levels of the important nutrients you require daily

SOURCES & RESOURCES

Foundational Supplements Program

The Need for Foundational Supplements (.pdf)

HPDI BLOG ARTICLES

Amending the HPDI Foundational Supplements Program

Vitamin C / Antioxidants

PRO-C and Ultimate Protector – Comparison of Antioxidant Formulas

Questions and Answers about Ultimate Protector

The Amazing Healing Potential of Natural Nrf2 Activators

Ultimate Protector™: First Impressions

Ultimate Protector™ Brunswick Labs ORAC5.0™ Test Results

Preventing Free-Radical Damage Using Ultimate Protector™

Description and Comparison of ORAC Tests for Well Known Plant Ingredients and Ultimate Protector™

Ultimate Protector and the Role of Foundational Supplements for Health

Natural Phytochemical Nrf2 Activators for Chemoprevention

New Directions for Preventing Free Radical Damage

Ultimate Protector flyer (.pdf)

Review of Scientific Research on Oligomeric  Proanthocyanidins (OPC) by Dr. Hank Liers

Vitamin C – An Amazing Nutrient by Dr. Hank Liers

High-RNA Superfoods

Rejuvenate! Berries & Herbs: Ingredients for Optimal Nutrition

9 Things to Know About Rejuvenate!™ Superfoods

High-RNA Rejuvenate!™ Superfood

Rejuvenate! – The Original, High-RNA Superfood

Natural Phytochemical NRF2 Activators for Chemoprevention

DIETARY NUCLEIC ACIDS – DR. BENJAMIN S. FRANK, PART 1

DIETARY NUCLEIC ACIDS – DR. BENJAMIN S. FRANK, PART 2

Super-Tasty Morning Nutritional Drinks

PRODUCTS / SUPPLEMENTS

Hank & Brian’s Mighty Multi-Vite!

Multi Two (caps and tabs)

PRO-C (vitamin C / antioxidant formula)

Ultimate Protector™ Nrf2 Activator

Essential Fats Plus E

Rejuvenate!™ PLUS

Rejuvenate!™ (Original)

Rejuvenate!™ Berries & Herbs

Rejuvenate! Superfoods: Product Comparison

Hydrogen products

RESTORE

HPDI FOUNDATIONAL SUPPLEMENTS

Vitamin D3 PLUS

MYO-MAG (magnesium)

Warrior Sleep & Warrior products

Intestinal Rejuvenation Formula

Prescript-Assist probiotic (soil-based organisms)

CONTACT US:

You can reach HPDI by calling 1-800-228-4265, email Support(at)IntegratedHealth.com, or visit the retail website: IntegratedHealth.com

Health care professionals and resellers can apply for wholesale account, which includes access to the HPDI reseller website: HealthProductsDistributors.com. Email: Support(at)HealthProductsDistributors.com.

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HYDROGEN FOR OPTIMAL HEALTH

Fred Liers PhD molecular hydrogen H2In recent months, I researched and sampled different hydrogen products, including molecular hydrogen and anionic hydrogen products. I posted an article titled Wonders of Molecular Hydrogen last month.

This month I continue writing about benefits of hydrogen for health. Yet, in today’s post I document my personal experience with it, as well as the experiences of a few other individuals who have benefitted from it.

For those who don’t know—and that included me not long ago—hydrogen is the subject of more than 500 peer-reviewed papers in the scientific literature. Hydrogen is rapidly becoming recognized as an important nutrient for health.

According the Molecular Hydrogen Foundation, studies show hydrogen to exhibit therapeutic potential in nearly every organ of the human body, and in 150 different human disease models.

As such, there is an explosion in the amount of research on hydrogen, and quantum leaps are being made in understanding its importance for health.

MY EXPERIENCE WITH HYDROGEN PRODUCTS

I began testing hydrogen products a few months ago. I began by drinking a pre-bottled hydrogen beverage known as H2Bev. Shortly thereafter, I sampled a tablet form that effervesces (fizzes) in water called Active H2.

MegaHydrate Active H2 molecular hydrogen

MegaHydrate and Active H2 are two products providing hydrogen I tested.

Since then I have tried other delivery methods, including a unique encapsulated product known as MegaHydrate, which provides hydrogen anions. I experience benefits from all of them. HPDI now carries all three products.

Here are benefits I notice after using all three products providing hydrogen:

• Greater Physical and Mental Energy. The first benefit I noticed was a increased physical energy closely followed by greater mental energy. This helps me throughout my day, especially in the later afternoons. If I experience a lull in energy, I can take an Active H2 tablet in water or a MegaHydrate and feel an immediate lift.

• Faster Recovery after Exercise. I frequently hike, as well as participate in aikido, yoga, and sometimes run. In each case, I notice decreased recovery times.

• Increased Clarity and Focus. This benefit perhaps relates to increased mental energy. However, beyond mental every itself, I experience clearer thinking and a better ability to focus.

• Less Need for Sleep. I can fall asleep later or wake earlier, with less tiredness during the day. I am not prevented from sleeping. I can just get by with less when necessary, it seems.

• Improved Mood. Maybe this benefit relates to increased physical and/or mental energy. However, for me it means going through the day on an even keel. My mood is pretty good to begin with. I feel this benefit could relate to general feeling of well being I seem to gain when using the hydrogen products.

I experienced these benefits immediately after I began consuming hydrogen-infused water and the MegaHydrate (capsules). I continue seeing these benefits as I have keep taking hydrogen, and have increase my intake. In fact, it feels as if these benefits may accrue over time, so I will continue taking hydrogen over the course of weeks and months ahead.

OTHERS’ EXPERIENCE WITH HYDROGEN

Besides myself, I recently spoke to a few friends and family members, some of whom I gave samples of hydrogen products to try. Here are benefits they report:

• Increased Energy

Nearly everyone I speak to reports increased energy. This may be among the most important benefits because not only because we can all use greater energy, but also because it shows how rapidly and effectively hydrogen works in the body.

• Easier Breathing

Almost everyone who I spoke to who has tried one or more hydrogen products say they breathe easier because of it. One person said it really helped their exercise performance. Another person said that since allergy season has started, this benefit is major for them because usually early spring is a time of difficult breathing for them due to the prevalence of pollens and other plant allergens.

• Sounder Sleep

I personally have noticed I need less sleep. However, others report to me they sleep more soundly. It may be that improved breathing is the reason for sounder sleep. But it may also be they are simply sleeping more soundly as a result of taking the hydrogen. In either case, they enjoy sleeping more soundly.

H2Bev molecular hydrogen H2 product bottle

H2Bev hydrogen-enriched water is pre-bottled, ready to drink.

I WILL ALWAYS TAKE HYDROGEN

Now that I’m testing three hydrogen products and receiving their benefits, I don’t want to be without them. Who wouldn’t want increased physical energy or mental energy or improved breathing? And as much as I gain from a full night’s sleep, the benefit of being able to get by with a little less when necessary is nice.

I have noticed a few other benefits:

• The need for less nutritional supplementation. I will always take nutritional supplements, but I have reduced the amounts I take of certain supplements. This may be due to increased absorption relating to the hydrogen.

• Eating less. I am not sure whether this directly relates to consuming hydrogen. It may be more related to how the body assimilates nutrients when hydrogen is present in my body. In any event, I am eating less and I am less hungry. I’m not depriving myself, I just feel more satisfied from the foods I eat. I have also heard this from others using hydrogen. I’m not sure whether they consider it a benefit or a side-effect. For now, I’m just making observations.

WHAT HYDROGEN PRODUCTS DO I LIKE BEST?

It’s difficult to say which of the three products I’ve tested that I like best. Each appears to have its place in my life.

I enjoy the convenience of H2 Bev when I’m traveling or even just taking a day trip. I can grab a bottle or two and go. I don’t have to worry about mixing tablets with water or taking an extra container with me, or remember to take a capsule.

Active H2 is great, too. It only takes a few minutes for the tablets to fizz. I use a glass or metal container. I would say that ounce-for-ounce Active H2 provides more hydrogen than H2Bev, so this is an advantage to me. Both of these products ensure hydration because you’re drinking water infused with hydrogen.

Megahydrate is the easiest to take due to its capsule form. I feel it offers more noticeable effects (and maybe 2–3 times as much hydrogen per dose as other products) and they last a long time. I don’t necessarily drink much water when taking Megahydrate, but it helps when I do. I need to remember to drink it with sufficient water, perhaps six to twelve ounces.

I really like Megahydrate, and it offers certain advantages. It has broad applicability like other hydrogen products. But it is unique because it has different modes of action containing an abundance of negative hydrogen ions within a colloidal silica matrix.

In fact, Megahydrate may be the ultimate hydrogen product (even better than molecular hydrogen). This is because it not only greatly enhances the production of ATP (cellular energy) in the body and the hydrogen it provides acts as a powerful antioxidant, but also because it can unlock the potential of water as a medium for nutrient replenishment and waste removal at the cellular level. This makes it a uniquely different product.

SUMMARY

Hydrogen is a worthy supplement with much scientific literature behind it. The fact that I receive similar benefits from three different products speaks well for the science. Regardless of which hydrogen products I use on a given day, what I gain from them is what matters most.

I will continue testing products providing hydrogen. I will write additional blog articles and perhaps update this post, as well. I recommend individuals try molecular hydrogen products for themselves because I believe most people will benefit significantly from them.

We also recommend checking out the website of the Molecular Hydrogen Foundation (www.molecularhydrogenfoundation.org), which provides scientific studies and technical information about hydrogen.

ADDITIONAL RESOURCES

Molecular Hydrogen Foundation (MHF)

Wonders of Molecular Hydrogen
by Fred Liers, PhD (from the HPDI blog)

Molecular Hydrogen (H2) at the Forefront of Health Research
by Hank Liers, PhD (from the HPDI blog)

ACTIVE H2 (tablet)

H2BEV (bottle)

MegaHydrate™ (capsule)

Contact Us:

You can reach HPDI by calling 1-800-228-4265, email support(at)IntegratedHealth.com, or visit the retail website: www.IntegratedHealth.com

Health care professionals and retailers can apply for wholesale account, which includes access to the HPDI reseller website: www.HealthProductsDistributors.com

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WONDERS OF MOLECULAR HYDROGEN

Fred Liers PhD molecular hydrogen H2I drink hydrogen-infused water. You should, too. Why? Because the age of hydrogen is here. Molecular hydrogen, that is. We now know that molecular hydrogen has therapeutic potential for nearly every organ in the human body, as well as for 150 different human disease models! And it’s extremely safe.

MOLECULAR HYDROGEN: BACKGROUND

Molecular hydrogen, also known as “diatomic hydrogen,” is a colorless, tasteless, and odorless gas.

Elemental hydrogen (H) is the most abundant element in the universe constituting 75% of its mass. Yet, it is absent on earth in its monoatomic form, being present in water, and inorganic and organic compounds. Molecular hydrogen is found in the earth’s atmosphere at less than one part per million.

molecular hydrogen H2 water

Hydrogen-infused water is a simple means to consume molecular hydrogen.

The science regarding benefits to health of molecular hydrogen (H2) has advanced rapidly in recent years thanks to the pioneering efforts of research scientists around the globe.

Now hydrogen science is moving quickly beyond theory to practical applications. Moreover, new products exist allowing medical professionals and consumers to leverage the health benefits of hydrogen.

For decades, diatomic molecular hydrogen was generally considered an “inert” gas. That is perhaps the primary reason that molecular hydrogen has been recognized as a therapeutic molecule only recently.

Indeed, science has known about the health benefits of molecular hydrogen as early as 1798. Yet, as noted, for most of modern history the belief persisted that hydrogen was inert in the body. It was only in the late 20th century (ca. 1975) that it gained the attention of medical researchers, and only in the past 10 years has evidence for the health effects of molecular hydrogen gained critical mass in the scientific literature.

There are now more than 500 peer-reviewed articles demonstrating the therapeutic potential of hydrogen for nearly every organ in the human body, as well as in 150 different human disease models, according to the Molecular Hydrogen Foundation.

HEALTH BENEFITS OF MOLECULAR HYDROGEN (H2)

• Molecular hydrogen reduces oxidative stress as a selective antioxidant and by maintaining homeostatic levels of glutathione, superoxide dismutase, catalase,  and other free-radical scavenging nutrients.

• The antioxidant capacities of molecular hydrogen are such that it is beneficial for persistent and acute oxidative stress.

• Acute oxidative stress arises from a multitude of causes, including inflammation, cardiac or cerebral infarction, organ transplantation, heavy exercise, cessation of operative bleeding, and many other causes.

• Persistent oxidative stress relates to reactive oxygen species (ROS) generated in the body throughout life. For example, during exercise, exposure to pollutants and toxins or UV light, as well as physical and psychological stresses, and the aging process itself. As aerobic organisms, we generate ROS when breathing consumes oxygen.

• Molecular hydrogen is effective against hydroxyl radicals (OH). The hydroxyl radical is the radical species that causes much of the oxidative damage in the body. While vitamin C, glutathione, and certain plant-based antioxidants are somewhat effective against this radical, there is no Nrf2-induced enzyme that effectively quenches the hydroxl radical.

• This positions molecular hydrogen as a uniquely effective antioxidant against the hydroxyl radical. Notably, when molecular hydrogen quenches the hydroxyl radical, it produces water, which is non-toxic in the body.

• Beyond this, molecular hydrogen, like other gaseous signaling molecules such as NO, CO, H2S, appears to exhibit cell signal-modulating activity that confers it with anti-inflammatory, anti-obesity, anti-allergy, and many other benefits.

MOLECULAR HYDROGEN MEDICINE

The scientific literature discusses the use of molecular hydrogen for many clinical applications, including the following:

• METABOLIC SYNDROME including diabetes, hyperlipidemia, arteriosclerosis, hypertension, and obesity

• ISCHEMIA / REPERFUSION injuries including cerebral and myocardial infarctions, organ transplants, post-cardiac arrest

• NEUROPROTECTION including applications for dementia, Parkinson’s disease, depression, and anesthesia

• INFLAMMATION including applications for polymicrobial sepsis, rheumatoid arthritis, wound healing, and bowel diseases

• MITOCHONDRIAL DISEASES

• HEMODIALYSIS / VENTILATION

• AGING including cognitive decline

• EXERCISE including applications for fatigue, lactic acid, recovery, and oxidative stress related to heavy exercise

SIDE EFFECTS OF CANCER THERAPIES including radiotherapy and chemotherapy

• MANY OTHER BENEFITS

athlete molecular hydrogen performance race

Athletes benefit from molecular hydrogen. You can, too.

HOW MOLECULAR HYDROGEN WORKS

According to the Molecular Hydrogen Foundation, there are three ways molecular hydrogen exerts positive health effects.

1.  Molecular hydrogen easily diffuses into subcellular compartments where it scavenges cytotoxic oxygen radicals, thereby protecting DNA, RNA, and proteins against oxidative stress.

2.  Molecular hydrogen triggers activation or upregulation of additional antioxidant enzymes (e.g., glutathione, superoxide dismutase, catalase, and others) and/or cytoprotective proteins of the body.

3.  Molecular hydrogen may be a novel signaling molecule that alters cell signaling, cell metabolism, and gene expression. This may explain its apparent anti-inflammatory, anti-allergic, and anti-apoptotic (or anti-cell death) effects.

MOLECULAR HYDROGEN IS SAFE

Molecular hydrogen exhibits great safety, and it is regarded as safe for use in the body. It is shown no toxicity even in high concentrations.

Safety standards are already established for high concentrations of molecular hydrogen for inhalation because high-pressure H2 gas is used in deep-water diving gas mixtures to prevent decompression sickness.

Notably, H2 gas combusts only at temperatures higher than 527 °C, and it explodes by chain reaction with oxygen (O2) only in the range of Hconcentration (4–75%, vol/vol).

Molecular hydrogen can be used for medical applications safely by several ingestion methods including inhalation of 1–4% hydrogen gas, which exhibits great effectiveness.

All these factors mean that molecular hydrogen is safe, easy-to-use, and effective for therapeutic purposes.

molecular hydrogen H2 water

Hydrogen-infused water is safe, easy-to-consume, and cost effective.

USING MOLECULAR HYDROGEN

Methods for consuming molecular hydrogen include inhalation, oral ingestion of hydrogen-infused water, injection of hydrogen saline, and direct diffusion (eye drops, baths, cosmetics, etc.).

An advantage of inhaled H2 gas is that is acts rapidly. In this respect, may be suitable for defense against acute oxidative stress.

It has been shown that inhalation of 3–4% hydrogen (H2) gas reaches a plateau at approximately 10–20 μM in the arterial and venous blood in about 20 minutes. This is shown not to affect any physiological parameters (e.g., blood pressure), suggesting no adverse effects.

According to the Molecular Hydrogen Foundation, the consensus is that drinking H2-rich water is the easiest, and often the most effective, method for obtaining molecular hydrogen although it does not provide as many hydrogen molecules to the body as other methods.

Some studies show consuming H2-infused water to be more effective than inhalation or increasing intestinal H2 production via lactulose administration.

Another advantage of drinking hydrogen infused water is that it allows gastric induction of ghrelin, which is mediated via activation of beta 1 adrenergic receptors.

Above all, drinking hydrogen-infused water is easy to do, and convenient as you can drink it at home or while traveling.

HYDROGEN-INFUSED WATER

Inhalation of molecular hydrogen gas may be impractical for continuous H2 consumption in daily life. In contrast, solubilized H2 (hydrogen-infused water) is a portable, easily administered, and safe means to ingest H2.

H2 can be dissolved in water up to 0.8 mM (1.6 mg/L) under atmospheric pressure at room temperature without changing pH.

Hwater can be made by several methods: infusing H2 gas into water under pressure, electrolyzing water to producing H2, and reacting magnesium metal or its hydride with water.

Notably, H2 penetrates glass or plastic walls of vessels in a short time, yet aluminum containers retain hydrogen gas for a long time.

Water ionizers produce hydrogen gas via electrolysis. This method produces hydrogen concentrations from less than 0.05 ppm to more than 2.5 ppm. Typically 0.1 to 0.7 ppm hydrogen is produced, yet most companies manufacturing water ionizers neither know the concentration produced nor understand the significance of hydrogen for health.

In this regard, depending upon the production method much of the water containing molecular hydrogen exhibits a negative oxygen reduction potential (ORP). Yet, ORP is only a general indication of hydrogen production and is not a measurement of its concentration.

A second method of producing hydrogen-rich water by electrolysis is by infusion. In this method, hydrogen is directly infused into filtered water within a machine.

Another convenient method to generate molecular hydrogen is to add alkali-earth metals to water. Magnesium metal in commonly used for this purpose. This method allows for the production of high concentrations of molecular hydrogen that are generally near saturation (1.6 ppm), and therefore less water needs to be consumed by individuals drinking it.

Magnesium sticks and tablets/capsules are available (some of which are placed in water and others that can be consumed directly) that rapidly produce 2–4 ppm molecular hydrogen concentration. Like electrolysis, adding metals to water also increased the pH of water because they reduce the concentration of H+ ions.

Other methods exist that can produce supersaturated concentrations of molecular hydrogen with or without alteration of water pH. Advantages of these methods include having to drink a fraction of the amount of water in order to obtain an equal amount of molecular hydrogen.

Drinking water containing molecular hydrogen is probably the easiest and most cost-effective means for most persons to obtain hydrogen.

man drinks water infused with molecular hydrogen

Hydrogen-infused water can be consumed using tablets, prepared H2 beverages, or ionized water.

MOLECULAR HYDROGEN FROM YOUR MICROBIOME

Certain types bacteria in the intestinal tract produce hydrogen gas from non-digestible fibers, which may explain how fiber-rich diets reduce inflammation, and exert cardiovascular and other health benefits.

Diets low in dietary fiber from fruits and vegetables, or a decrease in microbiome diversity could potentially reduce production of molecular hydrogen. This could exert adverse effects on health.

The presence (or absence) of a diverse and robust microbiome may be one of the most significant factors in terms of how much hydrogen can be generated in the body. Most people today do not create the levels of molecular hydrogen in their digestive tracts that humans in earlier time periods generated largely because due to modern diets and less than optimal microbiome health.

Factors that influence or reduce microbiome health and diversity include antibiotic use, imbalanced diet, lack of certain fiber-rich vegetables in the diet, and consumption of herbicides, pesticides, and GMOs (that include glyphosate) that harm microbial populations and cause “leaky gut”.

As knowledge increases regarding ways we can support a healthy microbiome, the biological significance of hydrogen historically produced in our digestive tracts will be better understood.

BENEFIT TODAY FROM MOLECULAR HYDROGEN

The clinical applications of molecular hydrogen are impressive. One of the great advantages of molecular hydrogen infused water is that  it is easy to consume it, or make it in your own home or wherever you happen to be.

HPDI now sells a tablet hydrogen product from Purative known as Active H2.

Active H2 is a unique, patent-pending combination of all-natural minerals used to generate molecular hydrogen and electron-rich potential (-ORP). This distinguishes it from existing hydrogen formulas and electrolysis (water ionizers).

Active H2 is easy to use.  Simply place one tablet of in a 1/2 liter (16 oz) container of pure water (filled to the top) and close tightly. Wait at least 5–10 minutes for it to completely disintegrate (fizz), and then drink.

A one pint glass mason jar works well as a container for this purpose. However, you can use up to one liter (about 32 ounces) of water in a container, so a quart mason jar also works well. Consume the hydrogen-infused water ideally at least 30 minutes before food.

Active H2 formula consists of a proprietary blend of pure magnesium, malic acid, fumaric acid, and maltose that synergistically act to generate molecular hydrogen and electron-rich potential (-ORP).

Active H2 is the only all-natural add-in tablet providing molecular hydrogen in the amount of greater than 1.8 ppm, That is, one tablet typically generates molecular hydrogen in the concentration of about 2 ppm.

There are other molecular hydrogen products, including tablets, sticks, and pre-infused bottled products like H2Bev. H2Bev provides about 1.2–1.5 ppm of molecular hydrogen and comes in a 12 oz coated aluminum container for excellent H2 retention.

MOLECULAR HYDROGEN SUMMARY

Molecular hydrogen sits in the unique position of providing significant, wide-ranging benefits for health with an unmatched ease-of-use, and at relatively low cost for what it delivers.

We highly recommend the use of molecular hydrogen for its health benefits and for therapeutic applications. This includes the consumption of hydrogen-infused water whether from prepared H2 beverages, water ionizers, or highly effective Active H2 tablets.

Below we include important scientific abstracts you may find helpful in understanding the benefits and applications of molecular hydrogen.

 

SCIENTIFIC STUDIES ON MOLECULAR HYDROGEN

Beneficial biological effects and the underlying mechanisms of molecular hydrogen – comprehensive review of 321 original articles

From: http://www.ncbi.nlm.nih.gov/pubmed/26483953

Abstract
Therapeutic effects of molecular hydrogen for a wide range of disease models and human diseases have been investigated since 2007. A total of 321 original articles have been published from 2007 to June 2015. Most studies have been conducted in Japan, China, and the USA. About three-quarters of the articles show the effects in mice and rats. The number of clinical trials is increasing every year. In most diseases, the effect of hydrogen has been reported with hydrogen water or hydrogen gas, which was followed by confirmation of the effect with hydrogen-rich saline. Hydrogen water is mostly given ad libitum. Hydrogen gas of less than 4% is given by inhalation. The effects have been reported in essentially all organs covering 31 disease categories that can be subdivided into 166 disease models, human diseases, treatment-associated pathologies, and pathophysiological conditions of plants with a predominance of oxidative stress-mediated diseases and inflammatory diseases. Specific extinctions of hydroxyl radical and peroxynitrite were initially presented, but the radical-scavenging effect of hydrogen cannot be held solely accountable for its drastic effects. We and others have shown that the effects can be mediated by modulating activities and expressions of various molecules such as Lyn, ERK, p38, JNK, ASK1, Akt, GTP-Rac1, iNOS, Nox1, NF-κB p65, IκBα, STAT3, NFATc1, c-Fos, and ghrelin. Master regulator(s) that drive these modifications, however, remain to be elucidated and are currently being extensively investigated.

Molecular hydrogen as a preventive and therapeutic medical gas: initiation, development and potential of hydrogen medicine

From: http://www.ncbi.nlm.nih.gov/pubmed/24769081

Abstract
Molecular hydrogen (H2) has been accepted to be an inert and nonfunctional molecule in our body. We have turned this concept by demonstrating that H2 reacts with strong oxidants such as hydroxyl radical in cells, and proposed its potential for preventive and therapeutic applications. H2 has a number of advantages exhibiting extensive effects: H2 rapidly diffuses into tissues and cells, and it is mild enough neither to disturb metabolic redox reactions nor to affect signaling reactive oxygen species; therefore, there should be no or little adverse effects of H2. There are several methods to ingest or consume H2; inhaling H2 gas, drinking H2-dissolved water (H2-water), injecting H2-dissolved saline (H2-saline), taking an H2 bath, or dropping H2-saline into the eyes. The numerous publications on its biological and medical benefits revealed that H2 reduces oxidative stress not only by direct reactions with strong oxidants, but also indirectly by regulating various gene expressions. Moreover, by regulating the gene expressions, H2 functions as an anti-inflammatory and anti-apoptotic, and stimulates energy metabolism. In addition to growing evidence obtained by model animal experiments, extensive clinical examinations were performed or are under investigation. Since most drugs specifically act to their targets, H2 seems to differ from conventional pharmaceutical drugs. Owing to its great efficacy and lack of adverse effects, H2 has promising potential for clinical use against many diseases.

Molecular hydrogen in drinking water protects against neurodegenerative changes induced by traumatic brain injury.

From: http://www.ncbi.nlm.nih.gov/pubmed/25251220

Abstract
Traumatic brain injury (TBI) in its various forms has emerged as a major problem for modern society. Acute TBI can transform into a chronic condition and be a risk factor for neurodegenerative diseases such as Alzheimer’s and Parkinson’s diseases, probably through induction of oxidative stress and neuroinflammation. Here, we examined the ability of the antioxidant molecular hydrogen given in drinking water (molecular hydrogen water; mHW) to alter the acute changes induced by controlled cortical impact (CCI), a commonly used experimental model of TBI. We found that mHW reversed CCI-induced edema by about half, completely blocked pathological tau expression, accentuated an early increase seen in several cytokines but attenuated that increase by day 7, reversed changes seen in the protein levels of aquaporin-4, HIF-1, MMP-2, and MMP-9, but not for amyloid beta peptide 1-40 or 1-42. Treatment with mHW also reversed the increase seen 4 h after CCI in gene expression related to oxidation/carbohydrate metabolism, cytokine release, leukocyte or cell migration, cytokine transport, ATP and nucleotide binding. Finally, we found that mHW preserved or increased ATP levels and propose a new mechanism for mHW, that of ATP production through the Jagendorf reaction. These results show that molecular hydrogen given in drinking water reverses many of the sequelae of CCI and suggests that it could be an easily administered, highly effective treatment for TBI.

The evolution of molecular hydrogen: a noteworthy potential therapy with clinical significance

From: http://www.ncbi.nlm.nih.gov/pubmed/23680032

Abstract
Studies on molecular hydrogen have evolved tremendously from its humble beginnings and have continued to change throughout the years. Hydrogen is extremely unique since it has the capability to act at the cellular level. Hydrogen is qualified to cross the blood brain barrier, to enter the mitochondria, and even has the ability to translocate to the nucleus under certain conditions. Once in these ideal locations of the cell, previous studies have shown that hydrogen exerts antioxidant, anti-apoptotic, anti-inflammatory, and cytoprotective properties that are beneficial to the cell. Hydrogen is most commonly applied as a gas, water, saline, and can be applied in a variety of other mediums. There are also few side effects involving hydrogen, thus making hydrogen a perfect medical gas candidate for the convention of novel therapeutic strategies against cardiovascular, cerebrovascular, cancer, metabolic, and respiratory diseases and disorders. Although hydrogen appears to be faultless at times, there still are several deficiencies or snares that need to be investigated by future studies. This review article seeks to delve and comprehensively analyze the research and experiments that alludes to molecular hydrogen being a novel therapeutic treatment that medicine desperately needs.

Molecular hydrogen as an emerging therapeutic medical gas for neurodegenerative and other diseases

From: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377272/

Abstract
Effects of molecular hydrogen on various diseases have been documented for 63 disease models and human diseases in the past four and a half years. Most studies have been performed on rodents including two models of Parkinson’s disease and three models of Alzheimer’s disease. Prominent effects are observed especially in oxidative stress-mediated diseases including neonatal cerebral hypoxia; Parkinson’s disease; ischemia/reperfusion of spinal cord, heart, lung, liver, kidney, and intestine; transplantation of lung, heart, kidney, and intestine. Six human diseases have been studied to date: diabetes mellitus type 2, metabolic syndrome, hemodialysis, inflammatory and mitochondrial myopathies, brain stem infarction, and radiation-induced adverse effects. Two enigmas, however, remain to be solved. First, no dose-response effect is observed. Rodents and humans are able to take a small amount of hydrogen by drinking hydrogen-rich water, but marked effects are observed. Second, intestinal bacteria in humans and rodents produce a large amount of hydrogen, but an addition of a small amount of hydrogen exhibits marked effects. Further studies are required to elucidate molecular bases of prominent hydrogen effects and to determine the optimal frequency, amount, and method of hydrogen administration for each human disease.

Molecular hydrogen is a novel antioxidant to efficiently reduce oxidative stress with potential for the improvement of mitochondrial diseases

From: http://www.ncbi.nlm.nih.gov/pubmed/21621588

Abstract

BACKGROUND:
Mitochondria are the major source of oxidative stress. Acute oxidative stress causes serious damage to tissues, and persistent oxidative stress is one of the causes of many common diseases, cancer and the aging process; however, there has been little success in developing an effective antioxidant with no side effect. We have reported that molecular hydrogen has potential as an effective antioxidant for medical applications [Ohsawa et al., Nat. Med. 13 (2007) 688-694].

SCOPE OF REVIEW:
We review the recent progress toward therapeutic and preventive applications of hydrogen. Since we published the first paper in Nature Medicine, effects of hydrogen have been reported in more than 38 diseases, physiological states and clinical tests in leading biological/medical journals. Based on this cumulative knowledge, the beneficial biological effects of hydrogen have been confirmed. There are several ways to intake or consume hydrogen, including inhaling hydrogen gas, drinking hydrogen-dissolved water, taking a hydrogen bath, injecting hydrogen-dissolved saline, dropping hydrogen-dissolved saline into the eyes, and increasing the production of intestinal hydrogen by bacteria. Hydrogen has many advantages for therapeutic and preventive applications, and shows not only anti-oxidative stress effects, but also has various anti-inflammatory and anti-allergic effects. Preliminary clinical trials show that drinking hydrogen-dissolved water seems to improve the pathology of mitochondrial disorders.

MAJOR CONCLUSIONS:
Hydrogen has biological benefits toward preventive and therapeutic applications; however, the molecular mechanisms underlying the marked effects of small amounts of hydrogen remain elusive.

GENERAL SIGNIFICANCE:
Hydrogen is a novel antioxidant with great potential for actual medical applications. This article is part of a Special Issue entitled Biochemistry of Mitochondria.

Recent progress toward hydrogen medicine: potential of molecular hydrogen for preventive and therapeutic applications

From: http://www.ncbi.nlm.nih.gov/pubmed/21736547

Abstract
Persistent oxidative stress is one of the major causes of most lifestyle-related diseases, cancer and the aging process. Acute oxidative stress directly causes serious damage to tissues. Despite the clinical importance of oxidative damage, antioxidants have been of limited therapeutic success. We have proposed that molecular hydrogen (H(2)) has potential as a “novel” antioxidant in preventive and therapeutic applications [Ohsawa et al., Nat Med. 2007: 13; 688-94]. H(2) has a number of advantages as a potential antioxidant: H(2) rapidly diffuses into tissues and cells, and it is mild enough neither to disturb metabolic redox reactions nor to affect reactive oxygen species (ROS) that function in cell signaling, thereby, there should be little adverse effects of consuming H(2). There are several methods to ingest or consume H(2), including inhaling hydrogen gas, drinking H(2)-dissolved water (hydrogen water), taking a hydrogen bath, injecting H(2)- dissolved saline (hydrogen saline), dropping hydrogen saline onto the eye, and increasing the production of intestinal H(2) by bacteria. Since the publication of the first H(2) paper in Nature Medicine in 2007, the biological effects of H(2) have been confirmed by the publication of more than 38 diseases, physiological states and clinical tests in leading biological/medical journals, and several groups have started clinical examinations. Moreover, H(2) shows not only effects against oxidative stress, but also various anti-inflammatory and antiallergic effects. H(2) regulates various gene expressions and protein-phosphorylations, though the molecular mechanisms underlying the marked effects of very small amounts of H(2) remain elusive.

Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals

From: http://www.ncbi.nlm.nih.gov/pubmed/17486089

Abstract
Acute oxidative stress induced by ischemia-reperfusion or inflammation causes serious damage to tissues, and persistent oxidative stress is accepted as one of the causes of many common diseases including cancer. We show here that hydrogen (H(2)) has potential as an antioxidant in preventive and therapeutic applications. We induced acute oxidative stress in cultured cells by three independent methods. H(2) selectively reduced the hydroxyl radical, the most cytotoxic of reactive oxygen species (ROS), and effectively protected cells; however, H(2) did not react with other ROS, which possess physiological roles. We used an acute rat model in which oxidative stress damage was induced in the brain by focal ischemia and reperfusion. The inhalation of H(2) gas markedly suppressed brain injury by buffering the effects of oxidative stress. Thus H(2) can be used as an effective antioxidant therapy; owing to its ability to rapidly diffuse across membranes, it can reach and react with cytotoxic ROS and thus protect against oxidative damage.

ADDITIONAL RESOURCES

MOLECULAR HYDROGEN (H2) AT FOREFRONT OF HEALTH RESEARCH
by Hank Liers, PhD (from the HPDI blog)

ACTIVE H2 (tablet product)

Molecular Hydrogen Foundation (MHF)

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