Today I talk about my REJUVENATE!™ BERRIES & HERBS high-RNA superfood. I designed it to be a super-delicious, intensely berry flavored superfood with no greens. I put in real organic berries—BLUEBERRY, STRAWBERRY, RASPBERRY, and CRANBERRY—so it bursts with true berry flavors! I recently updated the formula, so it is is more delicious and nutritious than ever.
REJUVENATE! BERRIES & HERBS – A COMPLETE SUPERFOOD
Rejuvenate! Berries & Herbs is a delicious high-RNA (390 mg), high-protein (14.6 g) (organic pea and organic rice), high-antioxidant (ORAC value of 14,000+), high fiber (13 g) superfood with a creamy smoothness and rich berry flavor that tastes beyond great! It also boosts health with a complete multivitamin-multimineral sub-formula and important cell-protective herbs (herbal complex) that includes ginger, dandelion, burdock, turmeric, green tea extract, astragalus, and many other health-building herbs.
How to use Rejuvenate! Berries & Herbs? Just mix in water, juices, nut milks, or smoothies to create a drink with superb health benefits. Or use it creatively in foods, such as nut butters, salads, fruits, sauce/dressings, or desserts. It tastes so good, some people like to eat it by itself—or mixed in a little purified water.
HEALTHY AND HIGH-RNA BY DESIGN
Rejuvenate! Berries & Herbs is among HPDI’s premier high-RNA superfoods. That is, Rejuvenate! Berries & Herbs is one of three Rejuvenate! superfoods, which are the world’s first—and only—dedicated high-RNA superfoods. High-RNA nutrition means high in dietary nucleic acids, which Dr. Benjamin S. Frank considers to be essential nutrients, like vitamins and minerals (Dietary Nucleic Acid Nutrition & Therapy). Dr. Frank’s studies demonstrate many benefits of nucleic acids, including: greater energy, endurance, functional strength, easier breathing (anti-anoxic effect), as well as cardiovascular benefits and cosmetic benefits (smoother skin and a more youthful appearance).
• Delicious Berry Flavor Bursts with Real Organic Berries! • Powerful Organic and Wildcrafted Cell-Protective Herbs • High ORAC Value (~14,270 units)
• 390 mg Dietary Nucleic Acids (RNA/DNA) from Vegetarian Sources • Multiple Prebiotics Supporting your Microbiome • Gluten Free, Vegan/Vegetarian, No Artificial Ingredients • Mixes Well with other Rejuvenate!™ Superfoods
My updated formula (as of 12/2018) features, per serving:
– 2.6 g more protein (14.6 g total) – Very little sugar (1.2 g total) – 7.0 g more fiber (13 g total) – 100 mg of organic BiAloe® aloe vera gel powder with over 18% acemannan – 700 mcg of folate as 5-MTHF (natural, coenzyme folate) – A smooth & delicious taste (even better than before!)
Given all the upgrades I recently made to the formula, I certainly hope you will give it a try. I’m so happy with it, and I use it daily. Berries & Herbs hardly feels (or tastes!) like a nutritional supplement. But believe me, there are few superfoods anywhere that provide as much nutrition—or nutrient density!
HIGHEST QUALITY INGREDIENTS – INCLUDING ORGANIC AND WILDCRAFTED
To give you a better idea of the high-quality ingredients I put into Rejuvenate! Berries & Herbs, check out this complete list of ingredients:
Today I make a tasty smoothie with the new, improved REJUVENATE!™ BERRIES & HERBS superfood. In fact, Rejuvenate! Berries & Herbs is likely the most delicious among HPDI’s Rejuvenate! superfoods, as it contains for types of real organic berries: Blueberries, Strawberries, Raspberries, and Cranberries. This uber-berry superfood was born for smoothies.
Rejuvenate! Berries & Herbs is a uniquely healthy superfood that not only tastes amazingly good, but its high berry content gives it an ultra-high antioxidant value (ORAC) of 14,270 units per serving—an exceedingly high ORAC value compared to typical “superfood” formulas.
Rejuvenate! Berries & Herbs provides 14.6 gm of organic protein (including organic pea and organic rice). It includes a potent cell-protective herbal complex (including green tea extract, ginger, turmeric, astragalus, burdock, dandelion, and rhodiola). In addition, it contains a built-in multivitamin sub-formula including coenzyme vitamins and other highly assimilable forms of important micronutrients.
I especially love Rejuvenate! Berries & Herbs because my father Dr. Hank Liers formulated it to provide the most dietary nucleic acids per serving—390 mg (dietary RNA/DNA)—the most per serving in any Rejuvenate! superfood. Sources of dietary nucleic acids in Rejuvenate! Berries & Herbs include nutritional yeast, yeast extracts, and CGF (chlorella growth factor).
Dietary nucleic acids are proven to provide significant benefits for health. Studies by pioneering nucleic acid researcher Benjamin S. Frank, MD, PhD indicate effects such as greater endurance, easier breathing (anti-anoxic effect), increased energy (ATP production), improved functional strength, warmer body temperature (e.g., cold resistance), and other effects. Dr. Frank asserts that dietary nucleic acids are essential nutrients, not unlike vitamins and minerals (Dietary Nucleic Acid Nutrition & Therapy).
Considering all the benefits conferred by dietary nucleic acids, you really cannot go wrong by consuming more of them daily. And Rejuvenate! Berries & Herbs helps you do that by providing nearly 400 mg of dietary RNA/DNA per serving. That is a therapeutic dose which means you stand to gain all the benefits they confer. Depending on who you are and your health status, that could mean a lot in terms of helping you be healthier.
In sum, Rejuvenate! Berries & Herbs uniquely offers: 1) High RNA (dietary nucleic acids), 2) High Antioxidant Levels, 3) Herbal Sub-Formula, 4) High Protein, 5) Built-in Multivitamin, and 6) SUPER TASTE—that is super delicious in your superfood smoothies.
You just cannot get all these benefits in ANY other superfood, including other Rejuvenate! superfoods, each of which is formulated with a specific purpose. For example, Rejuvenate! PLUS is designed to provide significant levels of greens (think chlorella and spirulina), but lacks berries. Within its berry bailiwick, Rejuvenate! Berries & Herbs truly stands alone as one-of-a-kind.
REJUVENATE! BERRIES & HERBS highlights:
• Delicious Berry Flavor Bursts with Real Organic Berries (blueberries, strawberries, raspberries, cranberries)! • Powerful Organic and Wildcrafted Cell-Protective Herbs • High Antioxidant (ORAC) Value of 14,270 units per serving! • Contains Multiple Prebiotics Supporting Your Microbiome • Suitable for Vegetarians and Vegans & Gluten Free • Mixes Well with other Rejuvenate!™ superfoods (like Rejuvenate! PLUS and Rejuvenate! Original Greens) and smoothie ingredients.
New, improved REJUVENATE! Berries & Herbs features (per serving): • 14.6 g protein • Very little sugar (1.2 g total) • 7.0 g more fiber (13 g total) • 100 mg of organic BiAloe® aloe vera gel powder with over 18% acemannan • 700 mcg of folate as 5-MTHF • Smooth texture & delicious taste!
There you have it. If you’re anything like me—and you love the taste of real, organic berries—consider Rejuvenate! Berries & Herbs to be your greatest ally when it comes it to tasty and healthy superfood nutrition. Make yourself a Berries & Herbs smoothie, and start creating health naturally today! ~
I previously published “Homocysteine Genetics – Coenzyme B Vitamins” in which I considered in-depth how homocysteine (an intermediate chemical in the Methylation Cycle) is formed from methionine, how genetics affects the metabolic pathways, and how B vitamins are used in metabolic pathways. I also wrote “Folate Ingredients – Folinic Acid & 5-MTHF” which discussed how coenzyme folate vitamins are far superior to the synthetic folic acid form. In today’s article, I take a broader view of the topic that encompasses the Methylation Cycle, genetics, and B vitamins.
THE METHYLATION CYCLE
The Methylation Cycle is considered to be one of the most important metabolic pathways in the human body. Its most important function is to provide methyl groups via SAM (S-adenosyl methionine) to hundreds of different body substrates. Methylation is continually occurring in the body, transforming many millions of molecules throughout the body every second. Molecules receive methyl groups, then separate and recombine continuously, transforming and reforming constantly in the ongoing process of life!
As a reminder of the pathways involved in the Methylation Cycle, the following figure provides a flow chart showing the details.
Figure 1. Metabolic Pathways in Methylation Cycle
A key purpose of this cycle is to provide methyl groups (CH3) needed by a broad range of of body functions (over 200 different functions). Examples include:
Influences the genetic expression that parents give their children and helps guide the development of the embryo.
Is needed by the nervous system to produce neurotransmitters and maintain the nerves.
Mobilizes fats and cholesterol so they do not accumulate where they are harmful, such as the arteries and liver.
Regulates hormones, including, estrogen, adrenaline, and melatonin.
Detoxifies harmful chemicals and histamine a prime substance involved in inflammation.
Helps repair damaged proteins in the cells so they can function properly.
Protects the DNA in the genome (genetic code) to reduce the chances of mutation.
Creates antioxidants used in the antioxidant defense system.
DESCRIPTION OF PATHWAYS WITHIN THE METHYLATION CYCLE
The overall flow of the Methylation Cycle begins with dietary methionine (an essential amino acid) which combines with ATP (adenosine triphosphate – body energy) to form SAM (S-adenosyl methionine) – the common cosubstrate involved in methyl group transfers, transsulfuration, and aminopropylation. When SAM transfers a methyl group to a body chemical the residue from this reaction leads to the production of homocysteine.
Homocysteine can be converted in the transsulfuration pathway that requires coenzyme vitamin B6 to produce cysteine, glutathione, taurine, and sulfates. These sulfur containing substances provide important antioxidant protection and detoxification functions in the body.
Homocysteine can be converted back to methionine through the betaine (trimethyl glycine) pathway which requires zinc and magnesium. This pathway also requires dietary betaine or choline which the body can convert into betaine.
Also, homocysteine can be converted back to methionine via the remethylation pathway which requires 5-MTHF, coenzyme vitamin B2 and methylcobalamin (B12).
It is important to understand that each of the pathways described above are able to be executed only in the presence of enzymes (shown in blue boxes in the diagram) created by specific genes in your genetic code. For example, Betaine-Homocysteine S-Methyltransferase (BHMT) is the enzyme required in the betaine pathway, Cystathione Beta Synthase (CBS) is the enzyme required in the transsulfuration pathway, and Methylenetetrahydrofolate Reductase (MTHFR) and Methionine Synthase (MS) are enzymes required in the remethylation pathway.
Assuming that you have perfect genetics (no mutations, SNPs, free radical damage, insertions/deletions, etc.), the proper functioning of these pathways are still subjected to the fact that the required vitamins and minerals (vitamin B6, vitamin B2, Folate, vitamin B12, zinc, magnesium, and betaine) need to be provided by your diet or from supplements for the body to function correctly.
In addition, exposure to high levels of toxins from your environment and high levels of stress require that the nutritional needs will be even higher for the pathways to work properly. For example, exposure to high levels of toxins requires that the transsulfuration pathway be more active possibly reducing the amount of available methionine to support necessary methyl transfer reactions.
For these reasons alone the consensus of knowledgeable practitioners is that you should be eating an organic whole foods diet, taking appropriate nutritional supplements, avoiding and eliminating toxins from food, water, and air (living in a clean environment), and avoiding an unduly stressful life. All of these actions fall into the category of Epigenetics which you generally have control over!! Doing these things alone could significantly balance the functioning of your Methylation Cycle and improve your health.
Unfortunately, few people have perfect genetics which often causes the various pathways in the Methylation Cycle to become imbalanced and unable to correct the dysregulation imposed upon the body. For example, the enzyme MTHFR can have heterozygous (single chromosome) genetic variations in up to 50% of certain populations and homozygous genetic variations (both chromosomes) in 10% or more of certain populations.
Some disorders that researchers have associated with MTHFR genetic variations include:
Chronic fatigue syndrome
High blood pressure
Irritable bowel syndrome
Migraines with aura
Nitrous oxide toxicity
Unexplained neurologic disease
This extensive list is highly significant and tells us that it is very important to have genetic testing done for the genes/enzymes in the Methylation Cycle pathway. I prefer the BodySync genetic test which evaluates the key Methylation Cycle genes plus many other important genes in a single test.
B VITAMINS AND MINERALS
We are strong believers that everyone should start their nutritional program by eating a balanced, organic, whole foods diet. We have been doing this ourselves for the past 30 years. Unfortunately, only a small percentage of people follow this advice and in most cases this leads to poor nutritional status that does not adequately support the body’s needs. This is especially true with respect to obtaining the nutrients needed to support the Methylation Cycle.
Nine of our family members and associates have taken the BodySync genetic test which evaluates the condition of 45 different enzymes including CBS, MTHFR (2 variations), MTR (related to B12 and 5-MTHF as they relate to methionine synthase – MS), and MTRR (related to maintaining B12 levels needed by the MTR enzyme). In every case the results showed at least 2 and up to 4 enzymes had genetic variations. These results indicate that the nutritional requirements for folate as 5-MTHF, vitamin B12 as methylcobalamin, vitamin B6, vitamin B2, magnesium and zinc will likely be significantly greater than normal.
Given the above information, it seems essential for good health to take nutritional supplements that provide the important nutrients. Below I will discuss various formulas that I have developed and refined over many years that are useful especially for the Methylation Cycle.
Please note that Health Products Distributors, Inc. (HPDI) is the preferred supplier of nutritional supplements by the BodySync genetic testing company.
When looking at the total needs the body has for nutrients that the body does not produce, including fat soluble vitamins (A, D (some), E, K1 and K2), vitamin C, B vitamins (B1, B2, B3, B5, B6, folate, B12, biotin, choline, and inositol), minerals (Ca, Mg, Zn, Se, Cu, Mn, Cr, Mo, K, boron, and vanadium), and betaine it only seems wise to include as a top priority a Multivitamin that includes all of these in what I term therapeutic amounts (carefully selected after evaluating thousands of research studies carried out over many years.)
In this context, it is important to recognize that every enzymatic reaction in the body requires mineral cofactors in order to carry out its function. A good multivitamin provides many of these required minerals.
Additionally, the multivitamin should contain ingredient forms that research has confirmed to be the most absorbable and usable by the body. These include coenzyme B vitamins, Krebs cycle (citrate, alpha-ketoglutarate, succinate, fumarate, & malate) minerals, and amino acid chelates.
In the context of supporting the Methylation Cycle we are looking for specific forms and amounts of B vitamins that can adequately provide the body’s needs. The means that there should be coenzyme folate as 5-MTHF of at least 400 mcg, coenzyme vitamin B-12 as methylcobalamin of at least 200 mcg, Vitamin B6 (including significant amounts of pyridoxal 5′ phosphate) of at least 40 mg, and Vitamin B2 (including significant amounts of riboflavin 5′ phosphate) of at least 25 mg. In addition, magnesium (100 mg) and zinc (at least 20 mg) should be provided.
Please note that the body’s requirements for magnesium is generally accepted by nutritional experts to be higher than 400 mg daily (and as high as 1,000 mg daily). For this reason we generally recommend that a person take supplemental magnesium (such as HPDI’s MYO-MAG) at levels over 400 mg daily.
The two multivitamin formulas Health Products Distributors provides for adults that meet these requirements (and more) are the Hank & Brian’s Mighty Multi-Vite and Multi Two (in both capsule and tablet forms). Click on the bottles below for technical details.
In situations where significant genetic variations are present it may be wise to add a B COMPLEX supplement to the MULTIVITAMIN to provide even larger amounts of the needed B vitamins. HPDI provides a B-Complex-50 product that includes significant amounts of coenzyme forms and contains 50 mg of Vitamin B1, 50 mg of Vitamin B2, 100 mg of Vitamin B3, 50 mg of Vitamin B6, 500 mcg of coenzyme folate (both folinic acid and 5-MTHF), 100 mcg of B12 (both methylcobalamin and hydroxocobalmin), 50 mg of Vitamin B5 (pantothenic acid), 500 mg of Biotin, 50 mg of choline, and 50 mg of inositol. Click on the bottle below for technical details.
FOLATE AS 5-MTHF
In situations where an inadequate diet is present and genetic testing indicates an MTHFR variation (especially a homozygous variation) Health Products Distributors provides a 5-MTHF folate supplement that easily absorbs into the body and can be directly used in combination with Vitamin B12 to convert homocysteine to methionine. Click on the bottle below for technical details.
5-MTHF 1 mg in veggie cap
B-12 as METHYLCOBALAMIN
It is often the case for older patients and vegetarians that Vitamin B12 is deficient. In these cases it is wise to supplement with a significant amount of methylcobalamin to ensure that the Methylation Cycle has sufficient to effectively convert homocysteine into methionine. Health Products Distributors Vitamin B12 contains 5 mg of methylcobalamin in sublingual lozenge form that supports excellent absorption even if swallowed and absorbed by diffusion. Click on the bottle below for technical details.
Magnesium and zinc are two important minerals used in the betaine pathway of the Methylation Cycle in which homocysteine is converted back to methionine.
In the body magnesium is involved in more than 400 essential metabolic reactions and is required by the adenosine triphosphate (ATP)-synthesizing protein in mitochondria. ATP, the molecule that provides energy for almost all metabolic processes, exists primarily as a complex with magnesium (MgATP). Therefore, it also is involved in converting methionine to SAM.
Over 300 different enzymes depend on zinc for their ability to catalyze vital chemical reactions. Zinc-dependent enzymes can be found in all known classes of enzymes.
Health Products Distributors provides 100 mg magnesium/vcap in its MYO-MAG supplement which is especially important in increasing ATP in the Krebs Cycle. This product also contains vitamin B1, vitamin B2, and vitamin B6 with substantial amounts of coenzyme forms and manganese. Click on the bottle below for technical details.
MYO-MAG with 100 mg magnesium per serving and key B vitamins.
Health Products Distributors provides 25 mg zinc/serving in its Double Zinc Plussupplement. This formula provides zinc in the picolinate and citrate forms as well as 3 mg of P5P (coenzyme B6). Click on the bottle below for technical details.
Double Zinc Plus supplement with P5P and 25 mg zinc
The Methylation Cycle is recognized as one of the most important metabolic pathways in the human body. When not properly supported by key B vitamins and minerals, the Methylation Cycle can become severely imbalanced which can lead to a very wide range of poor health conditions. Furthermore, genetic variations in the genes that produce important enzymes allowing the Methylation Cycle to function correctly lead to even further imbalances and greater possibility for conditions of poor health.
In this article, I have provided insight into how the Methylation Cycle works and how it can be significantly supported by lifestyle changes regarding diet and environment (Epigenetics) and by specific B vitamins and mineral supplements that I have developed over many years. In addition, we have shown that knowledge gained from genetic testing can further provide a critical understanding of your specific needs so that your health can be optimized.
As if Rejuvenate! PLUS weren’t already the delicious, nutritious superfood you know and love. Now, Dr. Hank Liers, HPDI’s formulator, has enhanced the formula for a truly remarkable taste and nutrition experience, you must try for yourself to believe!
The name Rejuvenate! Plus remains, but think of it as “version 2.0” because the nutritional upgrades and taste improvements are striking.
By the way, the “new” Rejuvenate! Plus is available now, so you can look forward to a truly remarkable user experience. We are confident you will be more than pleasantly surprised.
You will not believe your tastebuds when you try the new Rejuvenate! Plus. My humble opinion? Dr. Hank (my father and HPDI’s formulator) has knocked it out of the park in his revised formula.
Reports from sample testers have been overwhelmingly positive! Individuals who loved Rejuvenate! Plus unanimously love the new formula even more. That says a lot about this reformulation.
Rejuvenate! Plus 2.0 – healthy ingredients and taste at whole new level!
Other testers, who preferred our Rejuvenate! Berries & Herbs or Original Greens formulas either say they will now add Rejuvenate! Plus to their regimen, or will mix it in with their current favorite Rejuvenate! superfood.
Some individuals sampling the new formula who had never tried it before or previously did not often use Rejuvenate! Plus have decided to use it as their primary superfood—or take it daily.
We couldn’t be happier because these reports confirm the new Rejuvenate! Plus is a significant improvement over previous versions, and make our year-long effort to reformulate the product worth it. These early reports based on product samples show we have succeeded!
Some things haven’t changed: Rejuvenate! Plus remains the most popular and best-selling of all HPDI Rejuvenate superfoods. As always, it provide therapeutic levels (at least 340 mg) of dietary nucleic acids (RNA, DNA), greens (chlorella and spirulina) as in the lighter, sweeter greens (as compared to dark intense green-ness of Rejuvenate! Original greens) that both leads to slower, yet effective detoxification, and is powerfully energizing and cleansing. Rejuvenate! Plus also remains a foundational supplement that retains a complete built-in multivitamin sub-formula.
What then has changed? In short, we have changed a few ingredients, added or upgraded other ingredients, increased protein and nucleic acids (RNA) content, and created better tasting product overall. Here is a brief summary:
The “new” Rejuvenate! PLUS features (per serving):
1) 500 mg more spirulina (1,900 mg total), which actually increases the RNA content by about 15 mg
2) 2.3 grams more protein for a total of 13.9 grams
3) Almost no sugar (just 0.6 g total)
4) 2.3 g of powerful broccoli and alfalfa sprout extract powders
5) 200 mg of organic BiAloe® aloe vera powder with over 18% acemannan
6) 5-MTHF (500 mcg) — a better form of folate
6) An extremely smooth texture, and even more delicious taste—users rate as significantly better than prior versions—which says a lot because Rejuvenate! Plus already tasted great.
In short, these are the changes that make the new, improved Rejuvenate! Plus a significantly better product. Now I will delve a bit deeper into each of these changes, as well as specific changes to ingredients.
The new Rejuvenate! PLUS offers major improvements for optimal health.
REJUVENATE! PLUS IS A UNIQUE, HIGH-RNA SUPERFOOD
Rejuvenate! Plus is one three high-RNA superfoods Hank Liers of HPDI intentionally formulated to provide therapeutic levels of dietary nucleic acids. In this case, that means about 340 mg of nucleic acids per serving, and that has now been increased to at least 355 mg. The fact that Rejuvenate! Plus provides such high levels of dietary nucleic acids makes it—and the entire line of Rejuvenate! superfoods—unique!
A short history lesson: Benjamin S. Frank, MD, PhD discovered the benefits of dietary nucleic acids in the 1960s and 1970s. He performed various studies on humans and animals using various intakes of dietary RNA. He concluded that nucleic acids are essential nutrients like vitamins and minerals. Nucleic acids provide a host of unique health benefits that make getting RNA in your diet important.
After reading of Dr. Benjamin S. Frank’s works (including Dietary Nucleic Acid Nutrition and Therapy and The No-Aging Diet), my father Hank Liers and I decided to formulate a line of superfoods based on the idea of providing high levels of dietary nucleic acids for optimal health. That was 10 years ago.
Rejuvenate! Original Greens launched in 2007. Rejuvenate! Plus came two years later in 2009. Then Rejuvenate! Berries & Herbs in 2010. To this day, no other company has created dedicated high-RNA superfoods like HPDI’s Rejuvenate line.
DIETARY NUCLEIC ACIDS IN REJUVENATE! PLUS
What makes Rejuvenate! PLUS—and in fact the entire Rejuvenate! line of superfoods—unique? A single serving provides therapeutic levels (340+ mg) of dietary nucleic acids (RNA, DNA, nucleotides, and nucleosides). Here are a few of the benefits and effects of nucleic acids in the body:
HIGHER ENERGY (ATP) PRODUCTION
GREATER MUSCLE MASS / STRENGTH / ENDURANCE
SMOOTHER SKIN / MORE YOUTHFUL APPEARANCE
EASIER BREATHING / “ANTI-ANOXIA” EFFECT
ELEVATES TISSUE OXYGENATION
BENEFICIAL CARDIOVASCULAR EFFECTS
LOWER CHOLESTEROL LEVELS
OVERALL PHYSICAL REJUVENATION
TEMPERATURE TOLERANCE (COLD/HEAT)
IMPROVES LONGEVITY / QUALITY OF LIFE
FAR GREATER SUBJECTIVE WELL-BEING
Source: Nucleic Acid Nutrition and Therapy
Nucleic acids perform so many important functions in the body that getting sufficient amounts in the your diet is probably essential, just as Dr. Benjamin S. Frank asserts. That can be difficult since historically they were obtained from fish, organ meats—foods that people today may not consume in sufficiently high amounts for a variety of reasons. These reasons may include issues of taste, emphasis on vegetarian foods, concern about heavy metals or radiation, or lack of availability.
Rejuvenate! Plus in many ways helps take the guesswork from obtaining “essential” dietary nucleic acids by providing a vegetarian, gluten free, and non-GMO source of dietary RNA—along with protein, vitamins, minerals, cofactors, and other important nutrients—in a tasty, easy-to-take powder that stays fresh for months, travels well, and can be taken in a variety of ways from smoothies to plain water!
TRY REJUVENATE! PLUS
You (or your clients) have everything to gain by trying Rejuvenate! PLUS. As you can see, the updated superfood is carefully formulated to help create and maintain optimal health.
When used together with other HPDI foundational supplements and the HPDI supplement system, Rejuvenate! Plus is another “brick in your wall” of good health and can make a huge difference in terms of how you feel, perform, and function in life.
Try the new, improved Rejuvenate! PLUS “2.0” superfood. See for yourself not only how good it tastes, but how good it can help make you feel. That’s goodness all around!
We previously published an article titled FOLATE INGREDIENTS – FOLINIC ACID & 5-MTHF in which we discuss how coenzyme folate vitamins are far superior to the synthetic folic acid form. In today’s article, I take a more in-depth look at how homocysteine is formed from methionine, how genetics affects the metabolic pathways, and how B vitamins are used in metabolic pathways.
One way to look at the metabolic pathways of methionine (an essential amino acid) is that it provides a way for the body to convert this sulfur containing amino acid either to cysteine and its key by-products glutathione, taurine, and sulfates or allows remethylation back to methionine to occur using either the Folate Cycle or the Trimethyl glycine (betaine) pathways.
Figure 1 shows these metabolic pathways including the vitamins required at each step including vitamin B6 (as P-5-P), methylcobalamin, and 5-methyltetrahydrofolate (5-MTHF). In addition, it shows the key enzymes produced by the body at each step. These enzymes include CBS (cystathione beta synthase), BHMT (betaine homocysteine methyltransferase), MS (methionine synthase), and MTHFR (methylene tetrahydrofolate reductase).
Figure 1. Metabolic Pathways in Methionine and Homocysteine Metabolism
HEALTH ISSUES ASSOCIATED WITH HIGH HOMOCYSTEINE LEVELS
It is highly important that the various metabolic pathways function correctly to keep homocysteine at healthy levels (6–8 µmol/L). Unfortunately, high levels of homocysteine in the body (10–20 µmol/L) are a factor in a wide range of health issues, including:
Greater risk for heart problems, including coronary artery disease, heart attacks, stroke, high blood pressure, congestive heart failure, and abnormal cholesterol levels. This is due to increased inflammation, sometimes due to blood clotting spontaneously, and because of blockages of the major arteries.
Mental abnormalities such as depression, anxiety, bipolar disorder, and other mental problems are more common among people with high homocysteine
Migraines and headaches in a significant percentage of the population
In those who suffer from high homocysteine due to having nutritional deficiencies anemia, aches and pains, hearing loss, age-related macular degeneration (ARMD), slowed development, and birth defects might also be possible
Greater risk for dementia, Alzheimer’s disease, brain atrophy, and other cognitive problems
In children, skeletal and developmental abnormalities including having a curved spine or protruding chest and rib cage. Some patients appear very tall and thin, and some might also have very long, thin “spider-like” toes and fingers.
Behavioral problems, including ADHD, autism and other learning disabilities
ROLE OF GENETICS IN HOMOCYSTEINE METABOLISM
Ten or more years ago, questions of how genetics enters into homocysteine metabolism were unlikely to be asked. However, in recent years DNA testing has advanced and is now available to everyone (for example, see my article about Bodysync’s genetic test, DISCOVERING NUTRITIONAL NEEDS THROUGH ADVANCED GENETIC TESTING.
You may have heard a great deal about MTHFR (methylene tetrahydrofolate reductase). This gene is involved in folate metabolism and has a central role in methylation processes like repair of and building new DNA in dividing cells.
In the remethylation pathway for conversion of homocysteine to methionine, MTHFR plays a key role in converting folate into 5-MTHF which is needed along with B12 as methylcobalamin in order for the conversion to take place. Genetic variations in MTHFR have been studied in depth. Of the many variations studies the most significant ones appear to be variations of C677C such as C677T (referred to as heterozygous) or T677T (referred to as homozygous). The heterozygous variant appears in about 30–50% of the population and causes somewhat less efficiency in the conversion of folic acid to 5-MTHF. However, the homozygous variation occurs in about 10% of the population and can have serious effects due to converting little homocysteine back to methionine.
Another variation in MTHFR is called A1298A. These variations are A1298C and C1298C and will have similar effects to the C677C variations. It was interesting to me when I recently analyzed my Bodysync genetic test results showing I carry the variation A1298C (heterozygous), which indicates I may not be effectively converting homocysteine back to methionine.
Additionally, my Bodysync genetic test results also indicate that I have heterozygous variations in the CBS enzyme shown in Figure 1, as well as heterozygous variations in MTR and MTRR enzymes, which are involved with B12 levels in the remethylation pathway. These results indicate that I need to take higher levels of methylcobalamin and 5-MTHF.
IMPORTANCE OF COENZYME FORMS AND PROPER AMOUNTS OF B VITAMINS
Many of the B vitamins on the market today unfortunately are in synthetic form. The body can only use the natural coenzyme forms effectively. For example, the body needs vitamin B6 in the form of P-5-P (pyridoxal-5-phosphate), folate in the form of L-5-MTHF, and B12 in the form of methylcobalamin for proper metabolism of methionine. In some cases the body can use the synthetic forms of pyridoxine HCl, folic acid, and cyanocobalamin but pays a cost (e.g., in time and energy) by having to convert synthetic forms to coenzyme forms.
Add to the prevalence of synthetic B vitamins, the fact that genetic deficiencies are more common than previously assumed, and it becomes clear that the coenzyme forms of B vitamins in the proper amounts are extremely important.
Fortunately, I have always believed it best to include as many coenzyme forms as possible in the nutritional supplements I formulate (over the past 27 years). For example, all HPDI multivitamins include coenzymes of B1, B2, B6, B12, and folate (as 5-MTHF and folinic acid). This is uncommon in most multivitamin formulas on the market. For this reason our supplements are ideally suited to the prevention or resolution of most genetic problems regarding homocysteine.
In addition, I have always chosen to include higher amounts than most multivitamins on the market. We also make available 5-MTHF one milligram (1 mg) capsules and methylcobalamin five milligram (5 mg) sublingual tablets. When genetic variations are in play as discussed above, then providing relatively higher amounts of coenzyme B vitamins that support important requirements in the body seems necessary.
Interestingly, several other nutrients are involved in the pathways involving methionine and homocysteine. These include zinc, magnesium, and Vitamin B2. Our multivitamin formulas and magnesium formulas, especially Myo-Mag with its coenzyme B1, B2, and B6, are recommended to support these nutrient needs. Finally, it has been found that N-Acetyl-L-Cysteine (NAC) can significantly lower homocysteine (by up to 50%), most likely because its gives the body an excellent source of cysteine without have to use methionine.
In this article, I have shown the value of the use of genetic testing and high-quality coenzyme B vitamins in resolving health issues associated with high values of homocysteine in the body.