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MAXIMIZING HYDROGEN SUPPLEMENTS—MEGAHYDRATE AND ACTIVE H2 ULTRA—WITH pH ADJUST ALKALINIZING FORMULA

Fred Liers PhD pH adjust hydrogen supplementsToday, I talk about hydrogen supplements with a twist. Specifically, I discovered that a unique combination of three products—MegahydrateActive H2 Ultra, and pH ADJUST Alkalinizing Formula—provides surprising benefits. I put this combination, or concoction, into water to produce a hydrogen-infused drink with potent antioxidant quenching capacity that also rapidly alkalinizes the body (increasing pH levels and buffering acids), and provides the important minerals potassium and magnesium.

Combining hydrogen supplements with pH ADJUST creates a hydrogen-infused drink giving you benefits from 1) Two types of hydrogen, hydride (H-) and molecular hydrogen (H2) with antioxidant and energizing properties, 2) Increased pH levels (greater alkalinity) to balance pH levels, 3) Bicarbonates helping buffer acids and replenish bicarbonate reserves in the body, and 4) Essential minerals (potassium, magnesium) in bio-available forms.

In practical terms, this drink is energizing, anti-aging (party due to free-radical quenching effects), hydrating, and powerfully alkaline-forming! What this means for you might be a revolutionary drink that by giving your body all the antioxidant benefits of hydrogen plus increasing your pH levels turns can significantly improve multiple aspects of health.

By buffering acidity and making you alkaline, this drink can improve things like the strength of bones and teeth (via buffering and remineralization), supports kidney health (as kidneys are responsible for your bicarbonate reserves), boosts oxygenation (and thereby supports easier breathing) because alkaline cells hold more oxygen, and stops or reduces acid indigestion, acid reflux, and other acid-related problems. That could be just the beginning of the benefits you might receive because increasing your pH levels and normalizing alkaline conditions (i.e., pH 7.35–7.45) positively impacts many systems in the body.

WHY COMBINE pH ADJUST AND HYDROGEN SUPPLEMENTS?

pH Adjust, Megahydrate, and Active H2 Ultra are good supplements when used by themselves. That is, they work well as stand alone supplements. But I have found the combination of all three offers maximum antioxidant, alkalization, buffering, and mineralization benefits.

pH Adjust maximizes the effects of hydrogen supplements by boosting alkalinity and buffering capacity through the inclusion of effective, natural forms of important minerals and bicarbonates, including: potassium bicarbonate, magnesium carbonate, potassium glycinate, and sodium bicarbonate.

SYNERGY: HOW EACH PRODUCT CONTRIBUTES TO THE DRINK

There are potent synergistic effects to the combination of all three products. In particular, using both hydrogen negative ions (H-) or hydride and molecular hydrogen (H2) creates cascade effects in which hydrogen ions “recycle” themselves as antioxidants. The addition of pH Adjust brings its own set of benefits.

MEGAHYDRATE provides hydride or hydrogen negative ions (H-), also known as anions, that act significantly as antioxidants. These hydrogen ions can last up to three weeks in water. In the body, after the H- has donated its electron, it becomes simply “H” and proceeds to pair with another hydrogen atom to form H2 (molecular hydrogen), thereby continuing to exert free-radical quenching action. This is a major benefit of consuming H- in the quantities provided by Megahydrate.

ACTIVE H2 ULTRA provides molecular hydrogen (H2) directly into the body in significant amounts. Molecular hydrogen offers many benefits to the body, especially antioxidant benefits. Being an extremely small molecule, molecular hydrogen can enter into the smallest cellular compartments, including the nucleus of the cell, a place where most antioxidants are too large to enter) where it can exert its antioxidant capabilities. Molecular hydrogen actually provides a wide range of health benefits. (See the Molecular Hydrogen Institute (MHI) website for more information.)

pH ADJUST Alkalinizing Formula provides effective alkalinizing and buffering functions, as well as minerals (like potassium and magnesium) and bicarbonates needed for health. It is a fluffy, white powder that mixes easily in water, teas, coffee, and other liquids. It is formulated to rapidly increase pH levels, and acts as a buffering agent to balance pH in the body.

pH Adjust was created by my father, Dr. Hank Liers, HPDI’s founder and formulator of all “Dr. Liers Original” supplements. Dr. Hank been designing effective nutritional supplements since before 1988, the year he founded HPDI.

ph adjust hydrogen supplements active h2 ultra

ACID-BASE BALANCE CRITICAL FOR HEALTH

Acid-base balance is critical in the body, where a pH level of 7.35–7.45 must be maintained. Modern diets and lifestyles tend to be acidifying for the body. Diets high in animal foods that are not adequately balanced with vegetable foods lead to acidity. Other factors include overconsumption of grains, alcohol, and other acid-forming foods. Stress can also play a role due too the acidifying effects of stress hormones like cortisol.

Moreover, the aging process itself depletes bicarbonate reserves. As noted, pH Adjust contains bicarbonates that help replenish bicarbonate reserves necessary for buffering acids. Finally, a significant portion of the population has low intake of potassium and magnesium, which pH Adjust includes as part of its design.

pH Adjust also includes sodium bicarbonate (baking soda), which is a well known acidity buffer and alkalinizer. For users, advantages of pH Adjust over pure sodium bicarbonate include reduced sodium intake, improved taste, and the provision of potassium and magnesium.

POTASSIUM & MAGNESIUM FOR HEALTH

Potassium is critical in the body not only for alkalinity, but also for its role in the sodium-potassium pump which is important in the production of cellular energy (ATP) and for preventing too high levels of sodium from entering cells.

Magnesium is essential in the body and plays a role in wide range of functions, including cellular energy production, immune function, muscle and connective tissue health, and more than 400 enzyme reactions.

pH ADJUST is a highly effective buffering formula, which tends to bring pH levels (low or high) back into the optimal range (7.35-7.45). This buffering capacity means users can both avoid acidosis (high acidity) and alkalosis (high alkalinity).

MAKE THE DRINK

OPTIMIZE MEGAHYDRATE & ACTIVE H2 ULTRA BY ADDING pH ADJUST

Start with 8–16 ounces of fresh, purified water. Add 1–2 scoops of pH ADJUST, 1–2 capsules (or 1-2 scoops) of MEGAHYDRATE, and 1–2 ACTIVE H2 ULTRA tablets. Add the Active H2 Ultra tablets last, and let them effervesce completely (about 1 minute) before drinking.

This alkaline-forming, hydrogen-infused water is best taken on an empty stomach. It is ideal to drink in the morning or the afternoon (away from food). Allow at least 15–30 minutes before eating, or see what works for you. I sometimes eat light foods 10 minutes after taking this drink.

I recommend testing your pH levels (salivary and/or urinary) using pH test paper (litmus paper). pH test paper gives you a way to accurately track your pH levels. You can also use it to measure the pH of foods you consume, such as hydrogen-infused water and drinks containing pH Adjust.

Note: Many HPDI customers use pH Adjust in other drinks, including tea, coffee, and ketogenic coffee. Coffee can be acidic and acid-forming beverage, so adding pH Adjust helps buffer the acidity. Many users say pH Adjust tastes mild or good in coffee, and some say it adds a certain creaminess to it.

USE THIS ALKALINIZING HYDROGEN DRINK!

The only way you will know how beneficial hydrogen-infused water with pH Adjust can be—or how well it works for you—is to make it and use it! You will likely find yourself surprised by how energizing, alkalinizing, and mineralizing it truly is for you. And how good you feel when you drink it!

Consider testing the pH of your water first using pH test paper. Many people drink highly acidic water (pH 6 or less) without realizing it. Just because your water is filtered or purified does not necessarily mean it is alkaline. pH Adjust can “fix” this problem. Other people report that their water is highly alkaline (8.0+). Either way, pH Adjust can buffer the water to put it into the range slightly alkaline range of about 7.35–7.45. If you have extremely acidic water, you might need to use two servings of pH Adjust in 8–16 ounces of water. Play with it.

Let us know how this works out for you. We welcome your feedback and success stories!

MANY OTHER WAYS TO USE pH ADJUST

Hydrogen supplements and pH Adjust are made for each other, and create wonderfully alkalinizing hydrogen-infused water. But there are other ways to use pH Adjust. As I mentioned, you might like to read about making pH Adjust Coffee or Ketogenic Coffee using pH Adjust. Or watch my videos below. Also, did you know you can use pH Adjust in lemonade and other juices?

MY YOUTUBE VIDEOS

pH ADJUST COFFEE: https://youtu.be/72fAz9ob3bo
“How to use pH Adjust Alkalinizing Formula in Coffee”

KETOGENIC COFFEE VIDEO: https://youtu.be/yzyVbFD_JVA
“How to Make Keto Coffee with pH Adjust – Alkalinizing Coffee”

HOW TO USE PH ADJUST ALKALINIZING FORMULA: https://youtu.be/kuP2BuvMSXA

HOW TO MAKE LEMONADE AND USE pH ADJUST: https://youtu.be/deF7BZcFtEs

HYDROGEN SUPPLEMENTS IN DEPTH: ACTIVE H2 ULTRA and MEGAHYDRATE: https://youtu.be/gwFLv6M4uMo

PRODUCTS: pH ADJUST AND HYDROGEN

pH Adjust, Megahydrate, and Active H2 Ultra are available from Health Products Distributors, Inc. (HPDI):

pH ADJUST: http://www.integratedhealth.com/ph-adjust.html

MEGAHYDRATE: http://www.integratedhealth.com/megahydrate-60-caps.html

ACTIVE H2 ULTRA: http://www.integratedhealth.com/hydrogen-tablets.html

PH TEST PAPER (Hydrion brand): http://www.integratedhealth.com/ph-paper.html

HPDI RESOURCES

HPDI WEBSITE: http://www.IntegratedHealth.com
RESELLER SITE: http://www.HealthProductsDistributors.com

HPDI BLOG: http://www.integratedhealthblog.com
RESELLER BLOG: http://www.healthproductsdistributors.com/blog (a blog just for HPDI resellers)

HPDI NEWSLETTER: http://www.integratedhealth.com/newsletter.html

HPDI OFFICE (Oracle, AZ): 1-800-228-4265 (M-F 8–3:45 pm Arizona Time)

FACEBOOK: https://www.facebook.com/healthproductsdistributors
FACEBOOK GROUP (Creating Health Naturally): https://www.facebook.com/groups/creatinghealthnaturally

TWITTER: http://www.twitter.com/HPDIHealth

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pH ADJUST COFFEE – MAKE ALKALINE COFFEE

Fred Liers PhD pH Adjust coffeeToday I show how to use pH ADJUST Alkalinizing Formula to make coffee alkaline. When pH Adjust is added to coffee, it rapidly changes from an acidic pH level to an alkaline pH level.

When you drink alkaline coffee, you are helping your body keep the healthy pH level of 7.34–7.45 it strives to maintain. Moreover, by changing to an alkaline state from an acidic state, you avoid health issues known to be associated with acidosis or ongoing, highly acidic pH levels.

pH ADJUST makes an already health-giving beverage into an alkaline-forming powerhouse supporting your best heath and brain performance. pH Adjust also effectively increases pH when used in water, juices, smoothies, or your favorite beverage.

pH ADJUST works by providing key minerals potassium (bicarbonate and glycinate) and magnesium (carbonate), as well as some sodium bicarbonate (baking soda) that act synergistically to boost pH levels in the body. HPDI recommends users measure pH using litmus paper to accurately test their pH levels.

Ideally your body pH is 7.35–7.45. Coffee itself is typically acidic with pH levels of about 5.0 to 6.0. pH Adjust therefore is an ideal supplement for adding into coffee to increase the pH of the coffee you drink and thereby increase your pH levels.

WHAT IS pH ADJUST?

pH ADJUST is an alkalinizing formula (powder) that is designed to increase pH levels in the body rapidly and effectively for good health.

Here is how we describe pH ADJUST on the label: “Alkalinizing Formula, 250 gm – Alkalinize with Potassium Bicarbonate, Magnesium Carbonate, Potassium Glycinate, and Sodium Bicarbonate”

pH ADJUST Features and Benefits

• Alkalinize with Potassium and Sodium Bicarbonate and Magnesium Carbonate

• Helps Counteract Overly Acidic Conditions; Increases pH Levels in the Body

• Balanced Supplemental Minerals; Unique 3:1 Potassium to Sodium Ratio Improves Taste and Reduces Salt Intake

• Tastes Good – Easy to Use Fluffy Powder

• 250 One-Gram Servings Per Container (250 grams)

• Suitable for Vegetarians & Vegans; Gluten-Free

pH ADJUST may be used to assist in overly acidic conditions in the digestive tract, blood, and kidneys; increase salivary and urinary pH to healthy levels; and to supplement the body with the minerals potassium, magnesium, and sodium.

INGREDIENTS: pH ADJUST contains (in powder form): potassium bicarbonate, magnesium carbonate, potassium glycinate, and sodium bicarbonate.

Each one gram serving (about ¼ tsp) contains about 300 mg of bicarbonate, 260 mg of carbonate, 133.4 mg of potassium ((from KHCO3 & glycinate), 99.1 mg of magnesium (from MgCO3), 48.1 mg of sodium (from NaHCO3) and 100 mg of glycine.

DIRECTIONS: As a dietary supplement, take ¼ tsp in 4–8 ounces of purified water preferably away from food, or as directed by a health care professional. For extremely acidic conditions, try 4–10 doses per day, depending on acidity level. Use pH paper to ensure pH levels remain balanced, and do not become too alkaline (alkalosis may occur above pH 8.2).

TEST pH LEVELS: The best way to test pH levels is to use litmus paper, which HPDI offers in rolls (Hydrion brand) for this purpose. You can test both salivary and urinary pH. Advantages of pH paper include rapid results, ease of use, and cost effectiveness.

MORE INFORMATION ABOUT pH ADJUST

pH ADJUST is fluffy white powder that mixes into water, juices, other liquids, and foods. It acts rapidly to raise pH levels in the body. It is easy to use, mild-tasting, and highly effective for balancing pH levels. It is gluten-free, non-GMO, vegan/vegetarian, and contains no artificial ingredients.

NUTRITIONAL CONSIDERATIONS AND APPLICATIONS

The minerals potassium, sodium, and magnesium are key substances that are involved in many important functions in the body. When combined in bicarbonates (potassium & sodium), carbonates (magnesium), and glycinate (potassium) these chemicals can help to adjust and balance pH levels that are crucial to body function.

pH ADJUST provides a 3:1 ratio of potassium to sodium. This ratio keeps potassium levels relatively high with respect to sodium. The processed food diets with a high protein and low vegetable content consumed by many people in the US and elsewhere produce conditions in the body of acidity. This in turn leads to decreased oxygenation of our cells and a greater amount of anaerobic processes in metabolism. This, in turn, leads in inadequate ATP (energy) production and the presence of unwelcome anaerobic cells and organisms.

BICARBONATE

Bicarbonate is a major element in our body. Secreted by the stomach, it is necessary for digestion. When ingested, for example, with mineral water, it helps buffer lactic acid generated during exercise and additionally reduces the acidity of dietary components. Additionally, it has a preventive effect on dental cavities. Each ¼ tsp of pH ADJUST contains about 300 mg of bicarbonate.

Bicarbonate is present in all body fluids and organs and plays a major role in the acid-base balances in the human body. The first organ where food, beverages and water stay in our body is the stomach. The mucus membrane of the human stomach has 30 million glands which produce gastric juice containing not only acids, but also bicarbonate. The flow of bicarbonate in the stomach amounts from about 24 mg/hr for a basal output to about 73 mg/hr for a maximal output.

Thus, at least half a gram of bicarbonate is secreted daily in our stomach. This rate of gastric bicarbonate secretion is 2–10% of the maximum rate of acid secretion. In the stomach, bicarbonate participates in a mucus-bicarbonate barrier regarded as the first line of the protective and repair mechanisms. On neutralization by acid, carbon dioxide is produced from bicarbonate.

One serving (about ¼ tsp) of pH ADJUST contains about 300 mg of bicarbonate.

CARBONATE

pH ADJUST contains about 260 mg of carbonate (and 99 mg of Mg) in the form of magnesium carbonate. Magnesium carbonate is used as an antacid that gets converted to Magnesium Chloride (MgCl) and CO2 by stomach acid. MgCl is a well absorbed form of magnesium.

TRY pH ADJUST IN YOUR COFFEE

We strongly recommend trying pH Adjust in your coffee (or ketogenic coffee) to help alkalinize the body rapidly. Many people gain major benefits from drinking this simple, easy-to-use formula that is highly effective for raising pH levels. Beyond coffee, it works well in other drinks! Like water, teas, juices, or smoothies. Try pH Adjust and see how effectively it can alkalinize you.

ADDITIONAL RESOURCES

BUY pH ADJUST: http://www.integratedhealth.com/ph-adjust.html

pH Test Paper (Hydrion): http://www.integratedhealth.com/ph-paper.html

YOUTUBE VIDEOS

KETO COFFEE VIDEO: https://youtu.be/yzyVbFD_JVA
“How to Make Keto Coffee with pH Adjust – Alkalinizing Coffee”

HOW TO USE PH ADJUST ALKALINIZING FORMULA: https://youtu.be/kuP2BuvMSXA

HOW TO MAKE LEMONADE AND USE pH ADJUST: https://youtu.be/deF7BZcFtEs

BLOG ARTICLES

Alkalizine with Lemonade Diet and pH Adjust

Got Potassium?

Racing and Recovery with pH Adjust Alkalinizing Formula

Alkalinize Rapidly Using pH Adjust

pH Adjust Alkalinizing Formula – New Product!

BOOKS & ARTICLES

Acid-alkaline balance: role in chronic disease and detoxification
(Altern Ther Health Med, 13(4):62-5)

Acid & Alkaline by Herman Aihara

Bicarb Magical Mineral Supplement by Dr. Mark Sircus, Ac, OMD

REFERENCE

The Acid Alkaline Food Guide
by Dr. Susan Brown and Larry Trieviei, Jr.

Potassium Intake of the US Population (PDF)
(NHANES Food Surveys Research Group, USDA)

Potassium: Health Benefits, Recommended Intake

List of acid-forming and alkaline forming foods

ALKALINIZE WITH LEMONADE DIET & PH ADJUST

Fred Liers PhD lemonade pH Adjust alkalinizing formulaSummer is here. That means lemonade! As in the “Lemonade Diet” or “Master Cleanse.” The lemonade diet is famous since Stanley Burroughs wrote his classic, The Master Cleanser. Hollywood has used his lemonade diet for decades—for health and weight loss. In recent years, the lemonade diet has gone mainstream.

While safe, effective weight loss may be its “claim-to-fame,” the lemonade diet is useful as a kidney cleanser promoting the health of the kidneys and bladder system, including the entire urinary tract. The lemonade diet cleanses kidneys best when combined with kidney-specific herbs like Uva ursi, parsley, cornsilk, and juniper berry.

A major reason lemonade is beneficial for health is that it’s highly alkalinizing in the body. Lemonade itself is acidic on the pH scale. Yet, after it is in the body it acts as an alkalinizer! That might seem counterintuitive. But your health—and alkalinity—can count on lemonade to increase your pH levels.

Acid-alkaline balance is critical for health. Your body must maintain a pH of about 7.35–7.45. If you’re too acidic, then your body will find ways (even robbing your bones for minerals) to buffer acidity. Diets high in fruits and vegetables are more alkaline-forming, at least partly due to high potassium levels. High potassium levels drive higher alkalinity.

You can—and should—measure your pH using litmus paper. Once you’ve got a baseline of your pH levels, you can see for yourself how dietary changes—like the lemonade diet—help move your pH toward greater alkalinity and improved acid-alkaline balance.

Given that modern, Western diets high in meats and simple carbohydrates are acid-forming—often in the extreme—it makes sense that lemonade benefits anyone who needs to be more alkaline. Of course, I’m not talking about sugar-laden, or pre-mixed, artificially sweetened, fake lemonade drinks. I mean real lemonade—which is the only kind that works as a “master cleanser.”

I have written about the lemonade diet, as well about kidney & bladder cleansing. I often perform a 3–7 day summer kidney cleanse using kidney herbs—including tinctures and teas—and follow it with a few days of the lemonade diet.

lemonade diet

Make lemonade: squeeze fresh lemons, add maple syrup and cayenne pepper

This summer, I totally reversed order. I started with a 15-day lemonade diet and followed it with a three-day kidney cleanse. You can gain huge alkalinizing (and kidney cleansing) benefits from lemonade alone.

The original recipe for the Lemonade Diet:*

2 Tbsp organic Lemon or Lime Juice
2 Tbsp organic Maple Syrup (dark color/robust taste) (Grade A)
8 ounces fresh water
1/4 tsp organic Cayenne Pepper (optional)

(* from The Complete Master Cleanse)

Modify the recipe to suit your taste. The original recipe can be strong and sweet. However, it provides sufficient calories (from maple syrup) to live on for days, weeks, or longer. Try using lime juice for a different flavor. I often use more water—up to 16 ounces or more—for this amount of ingredients.

Among the nutritional supplements that helps me while lemonade fasting—and especially on the longer fasts—is Rejuvenate! Original Greens superfood. It is highly energizing and nourishing. I recommend using a green superfood like Rejuvenate! Original Greens because it is highly energizing and nutritious, yet light in the body and supports detoxification. You can put it directly into your lemonade or take it separately. I prefer to stir it into my second or third serving of lemonade—so early in the day—but not in my first dose of lemonade.

Not only does Rejuvenate! Original Greens provide powerfully nutrition, including important vitamins and minerals, it also supports detoxification processes as it contains chlorella (40%) and dietary nucleic acids (dietary RNA and DNA). The cell wall of chlorella uniquely has the capacity to grab onto heavy metals, chemical contaminants, and toxins—and sequester them for removal from the body. Dietary nucleic acids are energizing and support detoxification processes.

I have used the “Lemonade Diet” for 20 years—in all seasons—at home and “on the road.” I typically go for one to three weeks. I have successfully completed longer lemonade diets, including several for six weeks and at least one for two months. I may not take Rejuvenate! every day during a lemonade diet, but this superfood provides benefits that help turn a “good” master cleanse in a “great” one.

MY LEMONADE DIET—AND A TWIST

After 15 days of lemonade, I feel lighter, leaner, and totally alkaline. In fact, I am more alkaline after this lemonade diet than ever before. Why? Because I did something different this year—I added a twist to my routine.

Instead of following my usual lemonade diet, I added a new alkalinizing supplement called pH Adjust. It is a pure, white powder that you can add to water or lemonade (or other liquid drinks) providing minerals formulated to boost alkalinity: potassium bicarbonate and glycinate, magnesium carbonate, and sodium bicarbonate.

I sometimes added pH Adjust to my lemonade. Other times I took it by itself in water. I started at one-quarter teaspoon (1/4 tsp) daily, and worked up to one teaspoon (1 tsp) daily over the course of my lemonade diet. Adding pH Adjust to my regimen made a significant difference in my overall alkalinity by increasing my pH levels. And I could feel the difference.

pH ADJUST

pH Adjust is formulated specifically to alkalinize your body. I believe it can be more alkalinizing than lemonade itself. Yet, lemonade and pH Adjust work well together to increase pH levels.

I test my pH levels daily using pH paper. I find that when compared to lemonade alone, adding pH Adjust boosts my alkalinity noticeably. I easily maintained an alkalinity between 7.4 and 8.0 for my entire 15-day lemonade diet. That is, I could more easily maintain a higher alkalinity than with lemonade alone.

Note: If I were to continue the lemonade diet longer than two or three weeks, I would recommend reducing or stopping use of pH Adjust. That’s because while you most likely want maintain a relatively higher pH level than you had before you started the lemonade diet, it is best not to maintain a pH of 8.0 for extended periods as you run the risk of too high pH. That won’t be a problem for most people, but testing your pH levels using litmus paper is important. Then you will know your pH levels—and can more readily balance your pH.

After you complete the lemonade diet and return to consuming solid foods, then it is advisable to use pH Adjust to maintain a balanced, but relatively alkaline pH of about 7.45—which is actually an optimal pH for health.

Keeping you alkaline is what pH Adjust is formulated to do…and it fulfills that promise—easily! Now it’s up to you to test your pH, get started on a more alkaline-forming diet, and feel the difference for yourself. Once you’re in the proper alkaline range, you won’t want to go back. And you’ll be better for it!

SOURCES & RESOURCES

BOOKS & SCIENTIFIC ARTICLES

The Master Cleanser by Stanley Burroughs

The Complete Master Cleanse by Tom Woloshyn

Acid & Alkaline by Herman Aihara

Acid-alkaline balance: role in chronic disease and detoxification
(Altern Ther Health Med, 13(4):62-5)

Potassium Intake of the US Population (PDF)
(NHANES Food Surveys Research Group, USDA)

BLOG ARTICLES

Got Potassium?

Alkalinize Rapidly Using pH Adjust

pH Adjust Alkalinizing Formula – New Product!

Racing and Recovery with pH Adjust Alkalinizing Formula

PRODUCTS

pH Adjust
(alkalinizing formula)

pH paper
(Hydrion litmus paper)

Rejuvenate! (Original Greens) superfood

Rejuvenate! product comparison chart

HOMOCYSTEINE GENETICS – COENZYME B VITAMINS

Dr. Hank Liers, PhD homocysteine coenzyme B vitaminsWe previously published an article titled FOLATE INGREDIENTS – FOLINIC ACID & 5-MTHF in which we discuss how coenzyme folate vitamins are far superior to the synthetic folic acid form. In today’s article, I take a more in-depth look at how homocysteine is formed from methionine, how genetics affects the metabolic pathways, and how B vitamins are used in metabolic pathways.

One way to look at the metabolic pathways of methionine (an essential amino acid) is that it provides a way for the body to convert this sulfur containing amino acid either to cysteine and its key by-products glutathione, taurine, and sulfates or allows remethylation back to methionine to occur using either the Folate Cycle or the Trimethyl glycine (betaine) pathways.

Figure 1 shows these metabolic pathways including the vitamins required at each step including vitamin B6 (as P-5-P), methylcobalamin, and 5-methyltetrahydrofolate (5-MTHF). In addition, it shows the key enzymes produced by the body at each step. These enzymes include CBS (cystathione beta synthase), BHMT (betaine homocysteine methyltransferase), MS (methionine synthase), and MTHFR (methylene tetrahydrofolate reductase).

homocysteine metabolism diagram

Figure 1. Metabolic Pathways in Methionine and Homocysteine Metabolism

HEALTH ISSUES ASSOCIATED WITH HIGH HOMOCYSTEINE LEVELS

It is highly important that the various metabolic pathways function correctly to keep homocysteine at healthy levels (6–8 µmol/L). Unfortunately, high levels of homocysteine in the body (10–20 µmol/L) are a factor in a wide range of health issues, including:

  • Greater risk for heart problems, including coronary artery disease, heart attacks, stroke, high blood pressure, congestive heart failure, and abnormal cholesterol levels. This is due to increased inflammation, sometimes due to blood clotting spontaneously, and because of blockages of the major arteries.
  • Mental abnormalities such as depression, anxiety, bipolar disorder, and other mental problems are more common among people with high homocysteine
  • Migraines and headaches in a significant percentage of the population
  • In those who suffer from high homocysteine due to having nutritional deficiencies anemia, aches and pains, hearing loss, age-related macular degeneration (ARMD), slowed development, and birth defects might also be possible
  • Greater risk for dementia, Alzheimer’s disease, brain atrophy, and other cognitive problems
  • In children, skeletal and developmental abnormalities including having a curved spine or protruding chest and rib cage. Some patients appear very tall and thin, and some might also have very long, thin “spider-like” toes and fingers.
  • Behavioral problems, including ADHD, autism and other learning disabilities

ROLE OF GENETICS IN HOMOCYSTEINE METABOLISM

Ten or more years ago, questions of how genetics enters into homocysteine metabolism were unlikely to be asked. However, in recent years DNA testing has advanced and is now available to everyone (for example, see my article about Bodysync’s genetic test, DISCOVERING NUTRITIONAL NEEDS THROUGH ADVANCED GENETIC TESTING.

You may have heard a great deal about MTHFR (methylene tetrahydrofolate reductase). This gene is involved in folate metabolism and has a central role in methylation processes like repair of and building new DNA in dividing cells.

In the remethylation pathway for conversion of homocysteine to methionine, MTHFR plays a key role in converting folate into 5-MTHF which is needed along with B12 as methylcobalamin in order for the conversion to take place. Genetic variations in MTHFR have been studied in depth. Of the many variations studies the most significant ones appear to be variations of C677C such as C677T (referred to as heterozygous) or T677T (referred to as homozygous). The heterozygous variant appears in about 30–50% of the population and causes somewhat less efficiency in the conversion of folic acid to 5-MTHF. However, the homozygous variation occurs in about 10% of the population and can have serious effects due to converting little homocysteine back to methionine.

Another variation in MTHFR is called A1298A. These variations are A1298C and C1298C and will have similar effects to the C677C variations. It was interesting to me when I recently analyzed my Bodysync genetic test results showing I carry the variation A1298C (heterozygous), which indicates I may not be effectively converting homocysteine back to methionine.

Additionally, my Bodysync genetic test results also indicate that I have heterozygous variations in the CBS enzyme shown in Figure 1, as well as heterozygous variations in MTR and MTRR enzymes, which are involved with B12 levels in the remethylation pathway. These results indicate that I need to take higher levels of methylcobalamin and 5-MTHF.

IMPORTANCE OF COENZYME FORMS AND PROPER AMOUNTS OF B VITAMINS

Many of the B vitamins on the market today unfortunately are in synthetic form. The body can only use the natural coenzyme forms effectively. For example, the body needs vitamin B6 in the form of P-5-P (pyridoxal-5-phosphate), folate in the form of L-5-MTHF, and B12 in the form of methylcobalamin for proper metabolism of methionine. In some cases the body can use the synthetic forms of pyridoxine HCl, folic acid, and cyanocobalamin but pays a cost (e.g., in time and energy) by having to convert synthetic forms to coenzyme forms.

Add to the prevalence of synthetic B vitamins, the fact that genetic deficiencies are more common than previously assumed, and it becomes clear that the coenzyme forms of B vitamins in the proper amounts are extremely important.

Fortunately, I have always believed it best to include as many coenzyme forms as possible in the nutritional supplements I formulate (over the past 27 years). For example, all HPDI multivitamins include coenzymes of B1, B2, B6, B12, and folate (as 5-MTHF and folinic acid). This is uncommon in most multivitamin formulas on the market. For this reason our supplements are ideally suited to the prevention or resolution of most genetic problems regarding homocysteine.

In addition, I have always chosen to include higher amounts than most multivitamins on the market. We also make available 5-MTHF one milligram (1 mg) capsules and methylcobalamin five milligram (5 mg) sublingual tablets. When genetic variations are in play as discussed above, then providing relatively higher amounts of coenzyme B vitamins that support important requirements in the body seems necessary.

Interestingly, several other nutrients are involved in the pathways involving methionine and homocysteine. These include zinc, magnesium, and Vitamin B2. Our multivitamin formulas and magnesium formulas, especially Myo-Mag with its coenzyme B1, B2, and B6, are recommended to support these nutrient needs. Finally, it has been found that N-Acetyl-L-Cysteine (NAC) can significantly lower homocysteine (by up to 50%), most likely because its gives the body an excellent source of cysteine without have to use methionine.

SUMMARY

In this article, I have shown the value of the use of genetic testing and high-quality coenzyme B vitamins in resolving health issues associated with high values of homocysteine in the body.

 

SOURCES & RESOURCES

DISCOVERING NUTRITIONAL NEEDS THROUGH ADVANCED GENETIC TESTING.

FOLATE INGREDIENTS – FOLINIC ACID & 5-MTHF

The Homocysteine Revolution by Kilmer S. McCully, MD

Role of hyperhomocysteinemia in endothelial dysfunction and atherothrombotic disease
(Cell Death and Differentiation 11, S56–S64)

PRODUCTS

5-MTHF
(coenzyme folate)

Methylcobalamin
(vitamin B12)

B-Complex-50

HPDI Multivitamins

0

NO DEATHS FROM ANY DIETARY SUPPLEMENT: US POISON DATA SYSTEM

Dr. Hank Liers, PhD dietary supplementFred Liers PhD dietary supplement dshea

The recently published annual report of the American Association of Poison Control Centers indicates no deaths from dietary supplements in 2013. The annual report was published in the journal Clinical Toxicology and was based on information collected by the US National Poison Data System (NPDS).

The report also indicated no deaths from any amino acid product or herbal product.

vitamin dietary supplement safety

No deaths were caused by any dietary supplement in 2013 according to US NPDS data.

The full text of the January 16, 2015 press release obtained from the Orthomolecular Medicine News Service (OMNS) follows. ~

 

FOR IMMEDIATE RELEASE
Orthomolecular Medicine News Service, January 16, 2015

No Deaths from ANY Dietary Supplement

Zero Fatalities from Minerals, Vitamins, Amino Acids, Herbs, Homeopathic Remedies

by Andrew W. Saul, Editor

(OMNS Jan 16, 2015) There was not even one death caused by any dietary supplement in 2013, according to the most recent information collected by the US National Poison Data System. The new 251-page annual report of the American Association of Poison Control Centers, published in the journal Clinical Toxicology (1), shows no deaths whatsoever from any dietary supplement.

Additionally, there were zero deaths from any amino acid or herbal product. This means no deaths at all from blue cohosh, echinacea, ginkgo biloba, ginseng, kava kava, St. John’s wort, valerian, yohimbe, Asian medicines, ayurvedic medicines, or any other botanical. There were zero deaths from creatine, blue-green algae, glucosamine, chondroitin, melatonin, or any homeopathic remedy.

Furthermore, there were zero deaths from any dietary mineral supplement. This means there were no fatalities from calcium, magnesium, chromium, zinc, colloidal silver, selenium, iron, or multimineral supplements. Reported in the “Electrolyte and Mineral” category were two fatalities from the medical use of “Sodium and sodium salts.” These are not dietary supplements.

The US National Poison Data System is “the only comprehensive, near real-time, poisoning surveillance database in the United States. In 2013, poison professionals at the nation’s 55 poison centers managed about 2.2 million human poison exposures, with children younger than 6 accounting for about half of all poison exposure cases.”

No man, woman or child died from any nutritional supplement. Period.

If nutritional supplements are allegedly so “dangerous,” as the FDA, the news media, and even some physicians still claim, then where are the bodies?

 

References:

1. Mowry JB, Spyker DA, Cantilena LR Jr, McMillan N, Ford M. 2013 Annual Report of the American Association of Poison Control Centers’ National Poison Data System (NPDS): 31st Annual Report. Clinical Toxicology (2014), 52, p 1032-1283. ISSN: 1556-3650 print / 1556-9519 online. DOI: 10.3109/15563650.2014.987397.

The full text article is available for free download at http://www.aapcc.org/annual-reports/ . Minerals, herbs, amino acids and other supplements are in table 22B, pages 1247-1249.

2. http://www.aapcc.org/press/38/

 

Nutritional Medicine is Orthomolecular Medicine

Orthomolecular medicine uses safe, effective nutritional therapy to fight illness. For more information: http://www.orthomolecular.org

Find a Doctor

To locate an orthomolecular physician near you: http://orthomolecular.org/resources/omns/v06n09.shtml

The peer-reviewed Orthomolecular Medicine News Service is a non-profit and non-commercial informational resource.

Editorial Review Board:

Ian Brighthope, M.D. (Australia)
Ralph K. Campbell, M.D. (USA)
Carolyn Dean, M.D., N.D. (USA)
Damien Downing, M.D. (United Kingdom)
Michael Ellis, M.D. (Australia)
Martin P. Gallagher, M.D., D.C. (USA)
Michael Gonzalez, D.Sc., Ph.D. (Puerto Rico)
William B. Grant, Ph.D. (USA)
Michael Janson, M.D. (USA)
Robert E. Jenkins, D.C. (USA)
Bo H. Jonsson, M.D., Ph.D. (Sweden)
Peter H. Lauda, M.D. (Austria)
Thomas Levy, M.D., J.D. (USA)
Stuart Lindsey, Pharm.D. (USA)
Jorge R. Miranda-Massari, Pharm.D. (Puerto Rico)
Karin Munsterhjelm-Ahumada, M.D. (Finland)
Erik Paterson, M.D. (Canada)
W. Todd Penberthy, Ph.D. (USA)
Gert E. Schuitemaker, Ph.D. (Netherlands)
Robert G. Smith, Ph.D. (USA)
Jagan Nathan Vamanan, M.D. (India)
Atsuo Yanagisawa, M.D., Ph.D. (Japan)

Andrew W. Saul, Ph.D. (USA), Editor and contact person. Email: omns@orthomolecular.org. This is a comments-only address; OMNS is unable to respond to individual reader emails. However, readers are encouraged to write in with their viewpoints. Reader comments become the property of OMNS and may or may not be used for publication.

To Subscribe at no charge: http://www.orthomolecular.org/subscribe.html

OMNS archivehttp://orthomolecular.org/resources/omns/index.shtml

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Read this press release on supplement safety on the OMNS website: http://www.orthomolecular.org/resources/omns/v11n02.shtml

US National Poison Data System (NPDS): http://www.aapcc.org/data-system/

Annual Reports of the American Association of Poison Control Centers (AAPCC): http://www.aapcc.org/annual-reports/

Journal of Clinical Toxicology: http://omicsonline.org/clinical-toxicology.php