Rejuvenation Program: Part Four


Fred Liers PhD rejuvenation programThe HPDI Rejuvenation Program provides practices, protocols, and recommendations proven over 31 years. It is a complete program to rejuvenate, regenerate, and boost vitality to body, mind, and spirit. It is especially helpful for those who want to restore health.

The program emphasizes establishing basic nutrition, foundational nutritional formulas, and high-RNA Rejuvenate!™ superfoods and other sources of dietary nucleic acids. The program rests on six elements: 1) Attitude/Commitment, 2) Detoxification, 3) Preventing Toxicity, 4) Health Building Nutrition, 5) Building Powerful Immunity, and 6) Supporting Protocols.

The six foundational elements remain powerful individually, but act synergistically when combined to support optimal health. The results are greatly improved capabilities for your body to heal, regenerate, rejuvenate, and restore its vitality.

As I stated in Part Three of the Rejuvenation Program series, health building nutrition plays a major role in the process of rejuvenation. We recommend emphasizing organic and/or wildcrafted foods, consuming more plant-based foods, raw foods, and generally consuming natural, whole foods (e.g., avoiding refined/processed foods).

I also discussed foods recommended in our Rejuvenation Program. Our recommendations include consuming foods high in nucleic acids (RNA and DNA). RNA-rich foods include chlorella and  Rejuvenate!™ superfoods. Rejuvenate! superfoods provide therapeutic levels of nucleic acids to support optimal rejuvenation, revitalization, and health. They also provide supporting nutrients (e.g., d-ribose, coenzyme B vitamins) that maximize utilization and healing effects of dietary nucleic acids in the body.

HPDI offers three versions of Rejuvenate!, including Rejuvenate! (original greens)Rejuvenate PLUS, and Rejuvenate! Berries & Herbs. Rejuvenate! PLUS and Rejuvenate Berries & Herbs are the most complete. Both provide delicious taste, therapeutic levels of dietary RNA, nutrients that support the body’s use of nucleic acids (e.g., d-ribose), a complete multivitamin, essential fats, and high levels of protein.


Last month, I discussed dietary/food aspects of nutrition. Today, I present key roles played by what we call “foundational” (or sometimes “core”) nutritional supplements. Foundational nutritional supplements are one of the critical means to success in creating powerful health by establishing optimal nutrient status in the body. Foundational supplements include: 1) multivitamins, 2) An antioxidant / Vitamin C formula, 3) essential fats, and 4) high-RNA superfoods.

We have found that proper nutritional supplementation provides important nutrients not always easily available in the diet. This partly relates to the fact that our needs for nutrients have never been greater. In addition, there are various reasons that most foods are deficient in nutrients, and therefore cannot or do not provide levels of nutrients required to sustain optimal health.

Some reasons dietary supplements are necessary include the fact that most crops are grown in nutrient-deficient or depleted soils; increased demands by the body due to greater needs for nutrients (relating to detoxification, stress, pollution, etc.); biochemical individuality resulting in greater needs for certain nutrients depending on the biochemistry unique to individuals. Biochemical individuality means that a person may require many times the US Daily Value of specific nutrients. In fact, one person may need hundreds of times the amount of a nutrient compared to a different person.

In addition, needs change during the year due to environmental circumstances. Changing seasons, environments, air/water supply, etc. mean that an individual’s need for nutrients typically changes during the year (e.g., more vitamin D needed in the winter, more nutrients needed to deal with pollution associated with urban environments or stress, etc.). Nutrient density of foods also varies by location, season, etc. The availability of nutrients in foods (even organically grown foods) can vary substantially due to season, geography, growing methods, etc.

All these factors add up to the fact that it is difficult to ensure optimal nutrient status without supplementation. Because the need for nutrients is greater than ever for most people, the need for nutritional supplementation is also greater than ever. Nutritional supplements provide an effective (and cost effective) means to ensure the high levels of nutrients required to build, sustain, and maintain optimal health.



Foundational formulas are the primary supplements we recommend for success not only in our Rejuvenation Program, but also for helping create better health generally. In fact, foundational supplement formulas are the basic building blocks for establishing and maintaining high nutritional status at all times in any program. (While foods are your primary source of nutrients, nutritional supplements are the best way to ensure intake of nutrients needed for good health.)

As noted above, the four foundational nutritional supplements we recommend are: 1) a high-potency multivitamin, 2) an essential fats formula (omega-3 and omega-6), and 3) Vitamin C (preferably buffered) with antioxidants (especially bioflavonoids), and 4) Rejuvenate!™ superfoods (and/or other high-RNA superfoods).

These four types of foundational formulas are the most important supplements and superfoods. Even if you take no other dietary supplements, these are the formulas that ensure you get basic nutrients required for good health. In fact, no diet or nutritional supplementation program is complete without them.

I will now consider the four types of foundational formulas, explain how they function, and reasons why they essential for good health.


A high-quality, high-potency multivitamin is the single most important supplement you can take. A good multivitamin ensures you receive important nutrients not always available in optimal amounts in foods. Taking a multivitamin helps guarantee uptake of nutrients that ar e not readily available because modern diets have strayed far from traditional diets. In addition, modern lifestyles create far greater demands for critical nutrients even as many nutrients are increasingly less available from foods. Multivitamins help break the cycle of deficiency and degeneration.

Critical nutrients provided by a good therapeutic multivitamin formula include a wide range of essential vitamins, minerals, and cofactors. Such a formula will usually include trace minerals, fat-soluble vitamins (A, E, D, & K), coenzyme B vitamins, magnesium, or other nutrients known to be deficient in the diets of most individuals.

Important factors to consider when looking for a good multivitamin, include high-potency, forms, completeness, balance, assimilability (e.g., ease of uptake and rapid assimilation), ease of use (convenience), etc.

High-potency is important because for most nutrients, the so-called “daily value” is simply inadequate for most people. Most individuals need many times the daily value of vitamins for good health. This is because daily values are established based on minimum amounts required for sustain life (e.g., survival) rather than the optimal amounts needed for good health.

As noted, studies of biochemical individuality show that individuals may require many times greater amounts of specific nutrients than are needed by the average person. Because most vitamins (especially water soluble ones) are essentially non-toxic even in relatively large doses (i.e., hundreds or sometimes thousands of times the daily value), it pays to provide your body with larger amounts of critical nutrients that it may require because you may not be an ‘average’ person.

Complicating this picture is the fact that individuals needs for specific nutrients vary widely. Thus, for example, one person’s need for vitamin C may be somewhat higher than average, yet the same person’s need for vitamin D may be significantly higher than average.

The proper forms of the nutrients are another critical factor. While forms have not always been a prime consideration (either of consumers or formulators), they are critically important. Forms are worthy of attention because we know that the form of a vitamin or mineral can make a major difference in terms of how it assimilated and used in the body.

For example, Krebs cycle bionutrients (i.e., mineral carriers, such as citrates, malates, alpha-ketoglutarates, succinates, or fumarates) are known to be superior precisely because they are the forms naturally recognized and utilized in the body. This is because these forms are used in the Krebs cycle (or citric acid cycle) that is part of the metabolic pathway used to generate energy (ATP) from nutrients in foods. In contrast, elemental forms of minerals and/or forms that are not part of the Krebs cycle may be more difficult to assimilate because they must be converted into forms the body can use. The biological cost is reduced bioavailability, as well as cellular energy expense and time required for metabolic conversion. As you can see, forms matter for health!

Other important factors include completeness and balance. Completeness is important in a multivitamin because the body requires a wide range of nutrients working together to create and sustain health. Many multivitamins are neither complete nor balanced. This relates partly to the fact that multivitamins are often not designed with an understanding of nutrients, forms, or amounts needed for health. Consequently, many commonly available multivitamins incorporate less effective forms, inadequate amounts, and improper ratios of nutrients. This reflects a general lack of understanding by formulators about how nutrients work together to build and sustain health. In contrast, supplements are available that provide completeness and balance.

HPDI offers several high-quality, balanced, and complete multivitamins providing easily assimilated forms of nutrients in optimal amounts. These include Hank & Brian’s Mighty Multi-Vite!, Multi Two caps or tabs, and Chewable Kids Mighty-Multi! (which is also designed for adults to enjoy, too). We recommend our capsule formulas because they are the easier to assimilate. However, our tablet formulas are both effective and cost-effective. Children benefit greatly from a multivitamin, and for them we offer our chewable Kids Mighty-Multi! multivitamin formula.


Vitamin C is legendary for its healing capacities. Yet, it is notable that despite numerous studies and accolades by nutritionists, it remains underutilized by mainstream medicine and is completely under-appreciated for the healing powerhouse it represents for human health.

We include Vitamin C as a foundational formula because we understand its role in creating and sustaining optimal health. Vitamin C not only is a potent antioxidant, but also a powerful immune builder/anti-viral, cholesterol controller, and connective tissue strengthener. In fact, no other vitamin or nutrient can take its place in terms of what it can contribute to human health, longevity, and well-being.

Ever since Linus Pauling wrote Vitamin C and the Common Cold, Vitamin C has held a place of esteem among nutritional scientists and consumers of Vitamin C products. Pauling went on to present further studies and to write his best-seller How to Live Longer and Feel Better (rev. 2006). Vitamin C plays a major role both in his discussion of vitamins and in the supplement regimens he recommends.

In nature, Vitamin C is always combined with bioflavanoids. Bioflavanoids (such as rutin, quercetin, catechins, anthocyandins, and oligomeric proanthocyanidins (OPCs)), work synergistically with Vitamin C to create powerful antioxidant effects, counteract inflammation, and strengthen connective tissues. In addition, Vitamin C and bioflavanoids combine with other antioxidants (including glutathione, lipoic acid, and selenium) in a process called “redox cycling.” In this process, antioxidants protect and “spare” each other, thereby allowing for significantly increased antioxidant protection in the body.

We offer a variety of Vitamin C products, including formulas with bioflavonoids. Our Vitamin C formulas include Ultimate Protector+™, PRO-C™, Buffered Vitamin C tabs, and Buffered Vitamin C powder. We typically recommend taking a buffered Vitamin C product to prevent acidosis and help maintain proper pH levels in the body.

We consistently find that one of greatest means for success in creating health using dietary supplements is to ensure you take all four types of foundational formulas. For example, many people take one or two foundational formulas: a multivitamin, essential fats, Vitamin C plus bioflavonoids, and/or high-RNA superfoods. But how many people take all four daily? Do you take all four daily? You might be surprised at the results if you took them all daily. This is because foundational formulas work together synergistically and leverage each other in ways that exceed the health-building effects that can be expected when foundational formulas are taken individually.


Many people understand the need to take supplemental multivitamins. The need for essential fatty acids (EFAs) has gained increased attention recently, and it is no less important. More people are consuming fish, fish oils, and vegetarian sources of essential fats, including chia seeds. However, the need for supplementing diet with essential fats to ensure adequate daily intake has never been greater than today.

There are two basic essential fats: alpha-linoleic acid (omega-3) and linolenic acid (omega-6). Other fats are sometimes included as being essential fats, including gamma-linolenic acid (GLA), an important omega-6 fatty acid, and eicosapentanoic acid (EPA) and docosahexanoic acid (DHA), important omega-3 fatty acids.

Essential fats are considered ‘essential’ because they are needed for biological processes (i.e., they are required to sustain life) rather than acting only as a food-based source of energy (as do many other non-essential fatty acids). Humans, therefore, must ingest essential fatty acids both for survival and for good health.

Essential fats play multiple roles in the body and serve many different functions. These functions include being modified to make eicosanoids (affecting pain and inflammatory processes); regulating steroid production and hormone synthesis; regulating pressure in the eyes, joints and blood vessels; mediating the immune response; regulating smooth muscle and autonomic reflexes; are needed for oxygen transport from red blood cells to tissues; are necessary for kidney function and fluid balance; preventing clumping of red blood cells; regulating mood and depression, and regulating nerve transmission.

Every cell and organelle within the cells are encased and protected by membrane made of phospholipids. A major component of these phospholipids are essential fatty acids that control membrane fluidity and the ability to pass important nutrients into the cells and toxins out of the cells. Without adequate essential fats the cell membranes can become rigid and dysfunctional.

We offer an essential fats product, called Hank & Brian’s Essential Fats Plus E. This product contains EPA and DHA from highly purified fish oils, GLA from cold-processed borage oil, and full spectrum Vitamin E consisting of all eight natural forms of tocotrienols and tocopherols. These mixed forms of Vitamin E perform many beneficial functions in the body (such as lowering cholesterol and clearing plague out of blood vessels) and also protect the essential fats from oxidizing in the capsule and in your body. The ratio of EPA to GLA in this products is 4:1, which is considered the ideal ratio for optimal effects in the body.


Our recommendations for foundational formulas now include high-RNA superfoods. We first recommend a multivitamin, an antioxidant / Vitamin C formula, and essential fatty acids. After these three foundational formulas are established in a daily regimen, the addition of a high-RNA superfood further contributes to excellent health.

We include high-RNA superfoods (and especially recommend Rejuvenate!™ superfoods) in our foundational supplements program after having studied the remarkable healing powers of chlorella and other high-RNA nutrients for six years. When taken in sufficient amounts, superfoods high in ribonucleic acid (RNA) show remarkable effects in the body. These effects include higher energy levels, greater endurance, better muscle strength, easier breathing, lower cholesterol levels, reductions in angina pains (and other positive cardiovascular effects), more stable blood sugar, better vision, and a more youthful appearance (smoother skin, fewer wrinkles, etc.), and many other benefits.

Our assessment of dietary nucleic acids being essential nutrients is shared by scientists on the cutting-edge of nutrition. In Nucleic Acid Nutrition and Therapy, Dr. Benjamin S. Frank asserts that dietary nucleic acids (RNA, DNA) are “essential nutrients of human beings” as distinct from non-essential, accessory nutrients. He considers nucleic acids and nucleotides an essential dietary category, i.e., as being nutrients “just as essential for humans as vitamins, minerals, proteins, carbohydrates, and lipids” (Frank).

After having studied the positive health effects of dietary RNA in the clinic for more than 20 years, Dr. Frank asserted:

“[N]ucleic acids are an essential nutrient in our daily diets, and […] optimal health and reduced aging are clearly related to their intake, more than to any other nutrient. Nucleic acids in our diets are of paramount importance for the repairing of molecular and gross tissue degeneration, and for combating the process of aging by simple, effective and essentially non-toxic, natural means.”

Dr. Frank’s conclusion that RNA is more essential to health than any other single nutrient underscores the central role of nucleic acids for human health.

We share Dr. Frank’s conclusions regarding the “essential” nature of nucleic acids and nucleotides, and their central role in human health. In fact, it is our direct experience with the health-building effects of dietary nucleic acids (e.g., in chlorella and other foods) that led to further our knowledge of nucleic acid nutrition and therapy, and develop our line of high-RNA Rejuvenate!™ superfoods. Rejuvenate!™ superfoods both provide optimal levels of nucleic acids and include supporting nutrients (e.g., d-ribose, coenzyme B vitamins), which maximize the beneficial effects of dietary RNA for health.

The nucleic acids in Rejuvenate!™ superfoods work directly with HPDI’s other foundational nutritional supplements to create, sustain, and support optimal nutrition for health and healing. We recommend Rejuvenate!™ and/or other high-RNA superfoods as part of program of foundational nutritional supplements that work together to provide full spectrum nutrition. It is because foundational formulas provides a full spectrum of essential nutrients that it is critical to success in our Rejuvenation Program, and to create, maintain, and/or rebuild health.


The best news with respect to dietary nucleic acids is that while they are essential nutrients, their inclusion in our foundational supplement program powerfully leverages their effects by facilitating greater synergy among all nutrients available to the body via foundational supplements. This synergy means the total package of nutrients delivered by all four types of foundational supplements combined delivers far more health-building nutrition than any single foundational formula delivers individually. That’s synergy in action.

The means by which all four foundational supplements succeed in creating and contributing to powerful health relates less to the fact that each singly provides an ‘essential’ piece of the nutrition puzzle. Success relates instead to the fact that when all foundational formulas are taken together, their healthy benefits multiply and greatly exceed the sum of benefits provided by individual foundational formulas. This is a primary reason we emphasize establishing foundational nutrition both within our Rejuvenation Program, and more generally as a starting point for the creation of powerful health.



Dr. Hank Liers PhD supplement quality

The issue of nutritional supplement quality and purity has always been of great importance to Health Products Distributors, Inc. (HPDI). We entered the nutritional supplement industry in 1988 with the intention of providing the most pure and effective products possible and engaged in practices that ensured that our intentions for the highest quality and purity have been met (see below).

This issue is very important to me because on a daily basis I am dealing with the selection of ingredients, the selection and performance of our manufacturers, and the monitoring of product quality and testing.

vitamins quality purity safety

The HPDI approach emphasizes quality, minimal fillers, and good manufacturing practices (GMP).


Unfortunately, not everyone in the nutritional supplement industry did the same thing as HPDI. This has led to the industry organizations such as NPA and the FDA strengthening the good manufacturing practices (GMP) requirements and ensuring that the companies responsible for producing nutritional supplements were following the GMPs.

The issue of compliance with these GMPs is an ongoing concern. For example, in early February, the Office of the Attorney General for the state of New York sent cease and desist letters to four major US nutritional supplement retailers ordering them to stop selling seven herbal dietary supplements in their store brands.

The stores are GNC, Target, Walgreens, and Wal-Mart. The products are echinacea, garlic, ginkgo biloba, ginseng, saw palmetto, St. John’s Wort, and valerian root. An investigation of these products implied that several or all of the seven products tested are “either unrecognizable or a substance other than what they claimed to be, and therefore constitute contaminated or substituted products.”

The Natural Products Association (NPA) responded by letter to the Office of the Attorney General for the state of New York questioning the methodology for testing of the herbal ingredients and clearly state that federal regulations protect consumers. The link to the NPA’s letter is here.


For the record, we provide below practices that HPDI follows to ensure that our customers are getting the most effective supplements available. To accomplish this goal, we focus our expertise on the following areas:

Building a Line of Supplements Based on Strong Basic Research and Clinical Studies

  1. Formulas carefully designed to include ingredients demonstrated to be effective in clinical trials and research studies.
  2. Formulas balanced across the product line, so that consumers do not get either an excessive amount of any ingredient or an inadequate amount of important substances known to be important for balance in the body.
  3. Avoidance of a “shotgun” approach in formulation in which every possible ingredient known to be useful for a condition is included in a product. This approach often leads to imbalances in an overall supplement program.
  4. We maintain knowledge of latest nutritional research and clinical studies, and also maintain strong personal contacts with knowledgeable authorities in the field. We improve our formulas whenever possible.

The Highest-Purity, Highest-Quality Ingredients

  1. HPDI uses only the purest ingredients available (often USP or Pharmaceutical grades) and we specify a guaranteed or standardized potency whenever possible.
  2. Raw materials are obtained from reliable suppliers dedicated to providing the highest-quality ingredients.
  3. Our products are designed not to target price points, but to achieve the best results. For example, we choose whenever possible to use coenzyme forms of vitamins in our formulas that may cost ten times more than the usual forms used by vitamin manufacturers. Coenzyme forms of vitamins are the forms that are used in the body and are usually found in food.
  4. Use of the nutrient carriers best recognized and utilized in the body. We avoid sulfates, chlorides, carbonates, and oxides. As appropriate, we use Krebs cycle bionutrients (citrates, alpha ketoglutarates, succinates, fumarates, and malates), amino acid chelates (arginates, glycinates, aspartates, lysinates, etc.), and body-specific carriers (picolinates, polynicotinates, etc.).
  5. Giving the body options by providing multiple mineral carriers. For example, we often use both Krebs cycle and amino acid carriers.
  6. Formulating and packaging products that contain fatty acids to best protect them from oxidation both in the bottle and in the body. This may include the use of a gelcap, Vitamin E, ascorbyl palmitate (fat-soluble Vitamin C), rosemary, or a coated tablet to keep out moisture and oxygen.
  7. Our manufacturers generally include desiccants in the bottles of capsules and tablets in order to retain freshness.

Minimizing or Eliminating Unnecessary Fillers, Carriers, Excipients, Food Antigens, Preservatives, Coloring Agents, and Other Additives.

  1. Exclusion of wheat, gluten, corn, dairy, eggs, yeast, simple sugars, preservatives, artificial colorings, and artificial flavorings in our products.
  2. Exclusion (with just a few necessary exceptions) of rice, rye, barley, oats, soy, tomatoes, wax, and salicylates.
  3. Exclusion of dicalcium phosphate, rice powder, or synthetic fillers such as povidone. When absolutely necessary, we only allow USP grade microcrystalline cellulose as a filler.
  4. Avoidance of all lubricants with the exception of magnesium stearate, stearic acid or ascorbic palmitate in small amounts (less than 2%) when necessary for successful manufacturing of tablets or in some cases capsules.

The following link provides additional information on our approach to the excipients we allow in the HPDI products – HPDI Statement on Excipients

Working with Experienced and Trustworthy Manufacturers and Suppliers

  1. We conduct business only with manufacturing companies that are trustworthy, understand HPDI’s philosophy and approach to product formulation, pay close attention to our guidelines, and have excellent reputations for using “good manufacturing practices” (GMPs).
  2. We have worked with many of our manufacturers for over 10 years. For any new manufacturers we work with, an intense education program is engaged in that quickly brings them up to date concerning our demands for high-quality products.
  3. HPDI products are produced by manufacturers of superior-quality supplements following FDA manufacturing guidelines and who have cGMP certifications from the most demanding certifiers such as NSF and NPA.

In conclusion, I want to assure you that HPDI is continually monitoring the quality of the products we provide to our customers and improving them in any way possible!!


Congressional Research Supporting the Dietary Supplement Health and Education Act (DSHEA)

Dr. Hank Liers, PhD dietary supplementFred Liers PhD dietary supplement dsheaMore than 20 years after the United States Congress passed the Dietary Supplement Health and Education Act of 1994 (DSHEA), the text and the details of this statute of Federal legislation are not often discussed.

As a reminder to our readers (and ourselves), we present details in the form of the congressional findings (Section 2) that provide the logical underpinning of the Act.

We also include the title and Table of Contents of the Act (Section 1) for informational purposes, including links to the full text (of all 13 sections) hosted on the website of the Office of Dietary Supplements (ODS) of the National Institutes of Health (NIH).

United States Capitol Building with flag dietary supplement education dshea

The 103rd US Congress passed the Dietary Supplement Health and Education Act of 1994 (DSHEA) on October 25th, 1994.

The congressional findings (below) are part of the Act itself. They provide insights into the legislative intent of the law. That is, its reason for being (raison d’être) and the purposes for which it was passed by Congress. ~

Dietary Supplement Health and Education Act of 1994
Public Law 103-417
103rd Congress

An Act

To amend the Federal Food, Drug, and Cosmetic Act to establish standards with respect to dietary supplements, and for other purposes.

Be it enacted by the Senate and House of Representatives of the United States of America in Congress assembled,

§1. Short Title; Reference; Table Of Contents.

  • (a) Short Title.

This Act may be cited as the “Dietary Supplement Health and Education Act of 1994”.

  • (b) Reference.

Whenever in this Act an amendment or repeal is expressed in terms of an amendment to, or repeal of, a section or other provision, the reference shall be considered to be made to a section or other provision of the Federal Food, Drug, and Cosmetic Act.

  • (c) Table of Contents.

The table of contents of this Act is as follows:

Sec. 1. Short title; reference; table of contents.
Sec. 2. Findings.
Sec. 3. Definitions.
Sec. 4. Safety of dietary supplements and burden of proof on FDA.
Sec. 5. Dietary supplement claims.
Sec. 6. Statements of nutritional support.
Sec. 7. Dietary supplement ingredient labeling and nutrition information labeling.
Sec. 8. New dietary ingredients.
Sec. 9. Good manufacturing practices.
Sec. 10. Conforming amendments.
Sec. 11. Withdrawal of the regulations and notice.
Sec. 12. Commission on dietary supplement labels.
Sec. 13. Office of dietary supplements.

§2. Findings.

Congress finds that –

(1) improving the health status of United States citizens ranks at the top of the national priorities of the Federal Government;

(2) the importance of nutrition and the benefits of dietary supplements to health promotion and disease prevention have been documented increasingly in scientific studies;

(3)(A) there is a link between the ingestion of certain nutrients or dietary supplements and the prevention of chronic diseases such as cancer, heart disease, and osteoporosis; and

(B) clinical research has shown that several chronic diseases can be prevented simply with a healthful diet, such as a diet that is low in fat, saturated fat, cholesterol, and sodium, with a high proportion of plant-based foods;

(4) healthful diets may mitigate the need for expensive medical procedures, such as coronary bypass surgery or angioplasty;

(5) preventive health measures, including education, good nutrition, and appropriate use of safe nutritional supplements will limit the incidence of chronic diseases, and reduce long-term health care expenditures;

(6)(A) promotion of good health and healthy lifestyles improves and extends lives while reducing health care expenditures; and

(B) reduction in health care expenditures is of paramount importance to the future of the country and the economic well-being of the country;

(7) there is a growing need for emphasis on the dissemination of information linking nutrition and long-term good health;

(8) consumers should be empowered to make choices about preventive health care programs based on data from scientific studies of health benefits related to particular dietary supplements;

(9) national surveys have revealed that almost 50 percent of the 260,000,000 Americans regularly consume dietary supplements of vitamins, minerals, or herbs as a means of improving their nutrition;

(10) studies indicate that consumers are placing increased reliance on the use of nontraditional health care providers to avoid the excessive costs of traditional medical services and to obtain more holistic consideration of their needs;

(11) the United States will spend over $1,000,000,000,000 on health care in 1994, which is about 12 percent of the Gross National Product of the United States, and this amount and percentage will continue to increase unless significant efforts are undertaken to reverse the increase;

(12)(A) the nutritional supplement industry is an integral part of the economy of the United States;

(B) the industry consistently projects a positive trade balance; and

(C) the estimated 600 dietary supplement manufacturers in the United States produce approximately 4,000 products, with total annual sales of such products alone reaching at least $4,000,000,000;

(13) although the Federal Government should take swift action against products that are unsafe or adulterated, the Federal Government should not take any actions to impose unreasonable regulatory barriers limiting or slowing the flow of safe products and accurate information to consumers;

(14) dietary supplements are safe within a broad range of intake, and safety problems with the supplements are relatively rare; and

(15)(A) legislative action that protects the right of access of consumers to safe dietary supplements is necessary in order to promote wellness; and

(B) a rational Federal framework must be established to supersede the current ad hoc, patchwork regulatory policy on dietary supplements.


As we head into the 21st year since passage of DSHEA, we submit the text of the Act as a milestone in the history of US law. We look forward to a time when the sentiments expressed in the 1994 congressional findings may lead to revisions to the law and new laws that expand and support individuals’ proper use of dietary supplements.

For further details about DSHEA visit ODS (NIH) website (http://ods.od.nih.gov/About/DSHEA_Wording.aspx)


High-RNA Rejuvenate! Superfood

Dr. Hank Liers, PhDIn this article I will provide a bit of history and my excitement concerning the development of our high-RNA Rejuvenate! superfood. Over the past 25 years I have formulated hundreds of nutritional supplement products. As you may know, I first entered into the business of formulating and selling nutritional products because of my wife Joanne’s extreme multiple chemical sensitivities. The challenge to me always was to design products that even the most sensitive person could tolerate, and to create products that would provide significant benefit to individuals taking them.

I spent a great deal of my time reading scientific and clinical studies that showed the most effective forms and amounts of the ingredients. In addition, I read books on physiology, endocrinology, immunology, and biochemistry in order to understand how certain nutrients would be used in and affect the body. On occasions when I saw new possibilities for products with great potential I would take extra time with my research in order to ensure that I produced a groundbreaking product. This is the case with Rejuvenate!™.

Rejuvenate! High RNA Superfood rejuvenate


In 2004, I first learned about the benefits of ribonucleic acids (RNA) as nutritional supplements. Initially, I discovered the idea of consuming dietary nucleic acids from several books by Dr. Bernard Jensen that my son, Fred, was reading at the time. These books included Food Healing for Man (1983) and Chlorella: Jewel of the Far East (1992).

Dr. Jensen told the story of a man named Charlie Smith. According to Dr. Jensen, this man had received a honorary high school degree at the age of 133. When Dr. Jensen visited Charlie Smith, the oldest living American at the age of 135, he was healthy, clear-minded, and had a wonderful memory.

Dr. Jensen’s first question for Charlie was, “What have you been eating for the last 30 years?” Charlie’s reply was that he ate canned sardines and crackers. Dr. Jensen couldn’t believe it. But after some investigation, he found out that canned sardines were the highest-known food in RNA.

We soon discovered references in Dr. Jensen’s books to the works of Dr. Benjamin S. Frank. Among Dr. Frank’s writings is Dr. Frank’s No-Aging Diet (1976). As presented in his bestselling book, the main components of Dr. Frank’s diet are: 1) one three-to-four ounce can of sardines at least four days per week, and some fish including salmon and other seafood on the other days, 2) calf liver once per week, and 3) beans or lentils once or twice weekly.

Dr. Frank had done extensive research on both humans and animals using his diet. In his books, he recommends a diet high in nucleic acids to counter the aging process and essentially to rejuvenate the body. We were astonished at the health benefits (see list below) reported by Dr. Frank. Benefits he found not only include improved tissue oxygenation and cellular energy production, but also smoother skin and a more youthful appearance. It was an exciting time for us. We could hardly wait to try Dr. Frank’s “no-aging” diet for ourselves!














After learning about the many health benefits of dietary nucleic acids, my family immediately began consuming sardines on a daily basis. We felt and saw the difference! We noticed we had greater energy levels, breathed easier (especially noticeable when exercising), greater tolerance to cold temperatures, and even smoother skin. Even our dogs gained these benefits!

I was somewhat surprised at these noticeable effects on health since for many years we had already been consuming a healthy diet of organic foods, taking high-quality nutritional supplements, and getting plenty of exercise.

In another book written by Dr. Frank, Nucleic Acid Nutrition and Therapy (1977), he notably states that nucleic acids [RNA and DNA] are “essential nutrients of human beings,” as distinct from non-essential, accessory nutrients. He considered nucleic acids and nucleotides an essential dietary category, i.e., as being nutrients just as essential for humans as vitamins, minerals, proteins, carbohydrates, and lipids.

Dr. Frank acknowledged the body’s capacity to synthesize some nucleic acids, yet cited the marked improvements in degenerative conditions as the clearest evidence for nucleic acids as essential nutrients. In particular, he noted the health effects resulting from even relatively small intakes of nucleic acids (e.g., energizing effects, anti-anoxia effects, rejuvenation, greater vitality, etc). Dr. Frank found he could not obtain such improvements in his subjects by increasing only the intake of vitamins, minerals, proteins, or other essential nutrients.

Dr. Frank asserts: “Nucleic acids are an essential nutrient in our daily diets, and…optimal health and reduced aging are clearly related to their intake, more than to any other nutrient. Nucleic acids in our diets are of paramount importance for the repairing of molecular and gross tissue degeneration, and for combatting the process of aging by simple, effective and essentially non-toxic, natural means.”


I was absolutely impressed by the results we were observing, and by what Dr. Frank had discovered in his many experiments on humans and animals. But then things got more interesting! Because shortly thereafter, I read another book on chlorella by Dr. Jensen, Chlorella: Gem of the Orient (1987). Chlorella is single-cell freshwater algae with an RNA content in the range of 5–15%. Chlorella was being used extensively in Japan as a cure for virtually any illness.

My thoughts soon turned to developing a vegetable-based nutritional product that was a high-RNA superfood with nutrients that would support the body’s use of and production of  nucleic acids. Soon, I was reading every book written by Dr. Frank (a great challenge and learning experience in itself!) in order to gain a deeper understanding of what was required by the body in order to produce and utilize RNA. Piece by piece, the the elements of the formula fell into place. In January 2007, Rejuvenate!™ was ready. Here’s what Rejuvenate!™ contains:


  • Chlorella (Chlorella pyrenoidosa) . . . . . . . . .      5,000 mg
  • Nutritional Yeast (no added ingredients) . . . .      1,500 mg
  • D-Ribose . . . . . . . . . . . . . . . . . . . . . . . . . . . . .       1,500 mg
  • Chia Seeds (Organically Grown) . . . . . . . . . . .     1,000 mg
  • Rice Bran Solubles . . . . . . . . . . . . . . . . . . . . .        1,000 mg
  • Spirulina Pacifica® . . . . . . . . . . . . . . . . . . . .        1,000 mg
  • Magnesium Malate . . . . . . . . . . . . . . . . . . . . . .        300 mg
  • Magnesium Ascorbate . . . . . . . . . . . . . . . . . . . .       290 mg
  • Chlorella Growth Factor (CGF) . . . . . . . . . . . . . .     150 mg
  • Organic Dulse. . . . . . . . . . . . . . . . . . . . . . . . . .            75 mg
  • Organic Kelp . . . . . . . . . . . . . . . . . . . . . . . . . .             75 mg
  • Yeast Ribonucleic Acid (RNA) . . . . . . . . . . . . . . . .    40 mg
  • Calcium Folinate. . . . . . . . . . . . . . . . . . . . . . .         260 mcg
  • Methylcobalamin (Vitamin B12). . . . . . . . . . . . .   100 mcg

For an in-depth discussion of Rejuvenate! (original) please visit the HPDI website.

We have been extremely pleased with this product and the results gained by the individuals who consume Rejuvenate!™. Below are some of the testimonials we have received from satisfied customers.


“…My Skin Has Never Looked Better!”
– Stefanie L, Tucson, Arizona

“…a real energy booster! I’ve been surprised to feel increased vitality right away when drinking even a half dose!”
– Susanne L., Salisbury, Maryland

“I want to run a marathon! I wouldn’t be without this product for a day…”
– Karen W., Kirkcaldy, Scotland, UK

“I used to fight daily to not fall asleep in the afternoon, but now I have so much more energy…I go running in the afternoon even after surfing in the morning and waking up at 4:45 am!”

– Ariana H., Santa Cruz, California

“Best tasting green food I have tried out of many, congratulations!”

– Richard F., Virginia Beach, Virginia

“REJUVENATE! has been like a gift from God for my condition…thank you so much, more than words can ever say.”

– Jason W., Lake Arrowhead, California

“I am feeling better than I have in 30 years. (I am 63 years old.)…You can bet you have a repeat customer here. I will surely recommend this product to others.”
– D. Engel, Sibley, Iowa


After formulating Rejuvenate! (original greens), I created a complete line of high-RNA Rejuvenate! superfoods that provide a broad range of additional benefits. These include Rejuvenate! PLUS and Rejuvenate! Berries & Herbs.

Original Rejuvenate!™ remains our “greenest” superfood formula and contains the most chlorella per serving. Rejuvenate!™ PLUS is a lighter green, slightly sweet tasting superfood with an added multivitamin complex, and it provides the same total amount of dietary nucleic acids. Rejuvenate!™ Berries & Herbs offers an amazing berry taste, contains no greens, and not only provides the same amount of dietary nucleic acids, but also a built-in multivitamin complex and a cell-protecting herbal complex.

We know how effective Rejuvenate!™ superfoods are for total body rejuvenation, boosting health, supporting recovery and healing, boosting exercise performance, and improving personal appearance. We’d like you to experience these benefits, too.

Try any one of the Rejuvenate!™ superfoods for yourself, so you can start gaining all the benefits of dietary nucleic acids today! See our Rejuvenate!™ comparison page for more details about HPDI’s complete line of Rejuvenate! superfoods.

We also offer a pet version of Rejuvenate!™ known as Rejuvenate!™ For Pets. The ingredients in the pet Rejuvenate! formula are identical to the human version, but it comes packaged in a smaller container suitable for pets of all sizes and ideal for traveling.


  1. Chlorella: Jewel of Far East, Bernard Jensen, PhD, 1992.
  2. Chlorella: Gem of the Orient: The Dynamic Food Discovery for Health and Healing, Bernard Jensen, PhD, 1987.
  3. Dr. Frank’s No-Aging Diet, Dr. Benjamin Frank, 1976.
  4. Nucleic Acid Nutrition & Therapy, Benjamin S. Frank, MD, 1977.
  5.  Nucleic Acid Therapy in Aging and Degenerative Disease: A Metabolic Approach with DNA, RNA, and Related Metabolites, Benjamin S. Frank, 1969 (3rd ed.).
  6. A New Approach to Degenerative Disease and Aging: Effects of RNA, DNA with Other Metabolites. Dr. Benjamin S. Frank, 1964.
  7. Dr. Frank’s No-Aging Diet Cookbook, Barbara Friedlander Meyer, Marilyn Peterson, and Benjamin S. Frank, 1977.
  8. Food Healing for Man (vol. 1), Bernard Jensen, PhD, 1983.
  9. Chia: Rediscovering a Forgotten Crop of the Aztecs, Dr. Wayne Coates and Dr. Ricardo Ayerza, Jr., 2005.



Immune Strengthening using Medicinal Mushrooms

Dr. Hank Liers, PhDA healthy immune system is required for rejuvenation. Yet, often it is the immune system itself that requires rejuvenating to bring it to a level where it can better support rejuvenation of the entire body. Our Rejuvenation Program therefore builds the immune system and includes supplement recommendations and supporting protocols to accomplish that goal. The most important immune building supplement we recommend is Immune-Assist™, a mushroom complex of six medicinal mushrooms containing polysaccharides that provide a wide range of health benefits.

Other important immune building supplements included in HPDI’s Master Rejuvenation program are echinacea, garlic, olive leaf extract, and astragalus. We will discuss immune strengthening using medicinal mushrooms and Immune-Assist™ in this article. Additional articles (forthcoming) will be dedicated to the other immune-building supplements.

Medicinal Mushrooms Extracts: One of the Most Powerful Immune Modulators

Recent scientific research has shown that medicinal mushrooms grown on vegetable sources (such as millet, rice bran, buckwheat, barley, etc.) enzymatically activate a process whereby complex cross-linked polysaccharides from the vegetable sources are converted to biologically active immunomodulators (also known as biological response modifiers). As you will see from the discussion below, the polysaccharides produced by this process are effective and safe immune stimulants.



Medicinal mushroom research has focused on discovering compounds that can positively or negatively modulate the biological response of immune cells. Certain mushroom derived-glucans and polysaccharide-bound proteins have been shown to act as immunomodulators or biological response modifiers (BRMs). A variety of therapeutic effects often occur when these mushroom-derived polymers interact with the immune system to upregulate or downregulate specific aspects of the responses of the host. Whether certain compounds enhance or suppress immune responses can depend on a number of factors including dosage, route of administration, timing and frequency of administration, mechanism of action, or the site of activity.

Many mushroom-derived polysaccharides appear to fit the accepted criteria for BRM compounds. They cause no harm and place no additional stress on the body, they assist the body to adapt to the various environmental and psychological stresses, and they have a non-specific action on the body, supporting all the major systems, including nervous, hormonal, and immune systems, as well as regulatory functions.

The anti-tumor polysaccharides isolated from mushrooms (fruit-body, submerged, cultured mycelial biomass or liquid culture broth) are either water-soluble β-D-glucans, β-D-glucans with heterosaccharide chains of xylose, mannose, galactose, or uronic acid or β-D-glucan-protein complexes – proteoglycans.

While the role of medicinal mushrooms in immunomodulation and anti-cancer activities represents the central theme of much of the conducted research, it is pertinent to observe that many of the medicinal mushrooms have been highly valued for other medicinal properties including hypercholesterolemia, high blood pressure, diabetes, anti-viral, anti-bacteria, and antioxidant and free radical scavenging.

Mushroom-Derived β-glucans are Safe

The safety criteria for mushroom-derived β-glucans have been exhaustively carried out in pre-clinical experiments. Acute, subacute, and chronic toxicity tests have been carried out together with administration during pregnancy and lactation with no adverse effects. There were no anaphylactic reactions and no effects in mutagenicity and haemolysis tests, blood coagulation and a wide range of other regulatory tests.

There was no evidence of genotoxicity. Similar results have been obtained with other β-glucans. When applied to humans in Phase 1 clinical tests, the β-glucans demonstrate remarkably few adverse clinical reactions.

Therapeutic Properties of Medicinal Mushrooms

In the 2001 report Medicinal Mushrooms: Their Therapeutic Properties and Current Medical Usage with Special Emphasis on Cancer Treatments, a wide variety of mushroom polysaccharides, including Lentinan (from L. edodes), Schizophyllan (from S. commune), PSK and PSP (from Trametes versicolor), and Grifron-D (from the Maitake mushroom G. frondosa) and others are described, and their properties are shown to satisfy the criteria for BRMs.

Many of these mushroom-derived polymers potentiate the host’s innate (non-specific) and acquired (specific) immune responses in a similar manner, where they activate many kinds of immune cells that are vitally important for the maintenance of homeostasis. Key innate responses that are stimulated by these mushroom derived-β-glucans or polysaccharide-protein complexes include host T-cells (such as cytotoxic macrophages, monocytes, neutrophils, natural killer cells, and dendritic cells) and chemical messengers (cytokines such as interleukins, interferon and colony stimulating factors) that trigger complement and acute phase responses.

Moreover, mushroom polysaccharides or polysaccharide-protein complexes are considered as multi-cytokine inducers that are able to induce gene expression of various immunomodulatory cytokines and cytokine receptors. In addition, acquired responses are also enlisted, where lymphocytes that govern antibody production (B cells) and cell-mediated cytotoxicity (T-cells) are stimulated. While the immune system is shrouded in tremendous complexity, our current understanding shows that it is regulated in an orchestrated dynamic manner.

Mushroom-derived polysaccharides have shown anti-tumour activities in both pre-clinical models and in clinical trials. Although the mechanism of their anti-tumour action is still not completely clear, Lentinan, Schizophyllan, PSP, PSK and other mushroom polysaccharides appear to mediate their anti-tumour activity by activation or augmentation of the host’s immune system (via stimulated cytotoxic macrophages, cytotoxic T-cells and antibody-mediated cytoxicity of targeted cancer cells), rather than direct cytotoxicity.

Thus, both cell-mediated immune responses against the target T-cells initiated by macrophage-lymphocyte interactions and cytoxicity induced by antibodies to target T-cells are believed to contribute to the elimination of targeted tumour cells. Recent evidence suggests that several mushroom polysaccharides may also possess cytotoxic properties. Grifron-D from G.fondosa mushroom was reported to induce apoptosis (programmed cell death) in human prostate cancer cell-lines.

IMMUNE-ASSIST™ Incorporates Polysaccharide Extracts from Six Organically Grown Medicinal Mushrooms

In China, Japan, Korea, and more recently in the US, hundreds of mushroom species have been studied during the past 20 years. Extracts from most of the medicinal mushrooms show a common property of enhancing immune function by modulating cell-mediated immunity. Simply put, such mushroom extracts seem to turn on cells in the immune system, which appear to have significant disease-fighting properties. In fact, three different anticancer drugs extracted from mushrooms have been approved by the Japanese equivalent of FDA (that is, the Japanese Health and Welfare Ministry). These three are lentinan, derived from shiitake; PSK, derived from coriolus versicolor; and schizophyllan, derived from suehirotake.

Based upon a a large amount of research, a US-based company has formulated Immune-Assist™ , which includes a combination of more than 200 different polysaccharides, derived from the enzymatic breakdown of complex organic plant material from six different species of medicinal mushrooms. These include Agaricus blazei, Cordyceps sinensis hybrid, Lentinula edodes(shiitake), Grifola frondosa (maitake), Ganoderma lucidum (reshi), and Coriolus versicolor.

Immune-Assist™ contains simple polysaccharides similar to many other products on the market, but it also contains much more complex polysaccharides like the cross-linked beta mannans and beta-glucans, as well as hetero-polysaccharides which combine both alpha- and beta-bound monosaccharides into the same molecule. This is the reason that Immune-Assist™ shows such a greater range of immuno-modulation bioactivity than other bran-based supplements. Included among the important substances in Immune-Assist™ are Arabinoxylane, Lentinan, Grifolan (Dr. Nanba’s original Maitake D-Fraction), PSK and PSP, and Active Hemicellulose Correlated Compound (AHCC).

Below we provide a brief summary of the research and clinical studies for each of the mushrooms contained in Immune-Assist™:

Shiitake is now the most popular and most cultivated exotic mushroom in the world. In China, shiitake has a history that dates back to the Ming Dynasty (1368–1644 ACE). The mushroom was used not only as a food but was taken as a remedy for upper respiratory diseases, poor blood circulation, liver trouble, exhaustion and weakness, and to boost chi, or life energy.  It was also believed to prevent premature aging.  Today the shiitake is recognized for its antitumor action and has been extensively researched in regard to its immunologic activity. The initial antitumor research was performed in 1969 by Tetsuro Ikekawa at Purdue University, along with colleagues at the National Cancer Center Research Institute in Tokyo. The researchers found that water extracts of shiitake produced high rates of tumor inhibition in mice (72–92%). Ikekawa later identified a polysaccharide in shiitake called lentinan as having powerful antitumor activity.

Coriolus (or Trametesversicolor is the most thoroughly clinically researched mushroom. An extract of Coriolus versicolor known as PSK is sold in Europe and Japan. It is the best-selling cancer drug in the world and recently accounted for more than 25% of Japan’s total national expenditure for anticancer agents. In addition to possessing many different antitumor properties, it is also an immunostimulant; demonstrates anti-viral activity; enhances T-cell proliferation; and has been shown to improve both disease-free and survival rates in cancer patients. In an 8-year clinical test of breast cancer patients, and in another 5-year study, it was shown that the polysaccharide compounds contained within Coriolus versicolor work particularly well as an adjuvant for cancer therapies, exhibiting diverse biological activities.

Maitake may be even more potent than any of the other mushrooms previously studied. This legendary giant mushroom has been studied for its anticancer, anti-diabetic, anti-hypertensive and anti-hyperlipemic effects since the mid-1980s. Its anti-HIV activity in vitro was demonstrated in tests conducted by the Japan Institute of Health and the US National Cancer Institute in early 1992. Among various extracts obtained from the Maitake mushroom, a specific extracted fraction named Maitake D-fraction is the active constituent. This extract contains beta-1, 3-glucans and beta-1, 6-glucans protein-bound polysaccharides. It has demonstrated remarkable antitumor activity by activating the immune system through oral administration.

The Chinese people have long used Cordyceps sinensis to promote overall good health, and modern research indicates that it does indeed support liver, kidney, heart, and immune system function. Cordyceps sinensis has been used to protect the bone marrow and digestive systems of mice from whole body irradiation. One experiment noted that Cordyceps may protect the liver from damage. An experiment with mice indicated the mushroom may have an anti-depressant effect. Researchers have observed that Cordyceps has a hypoglycemic effect and may be beneficial for people with insulin resistance. Cordyceps mushroom extracts have been shown to stimulate the number of T helper cells, prolong the survival of lymphocytes, enhance TNF-alpha and interleukin 1 production, and increase the activity of natural killer cells. One study indicates that cordyceps can stimulate progesterone production in animal cells. Another study has shown that cordyceps may be effective against tumor cells by down-regulating MHC class II antigen expression. In addition, historical use data suggests that cordyceps can cause a reduction of cyclosporin and aminoglycoside-induced renal toxicity.

Reishi possess anti-tumor, immunomodulary, and immunotherapeutic activities, supported by studies on polysaccharides, terpene, and other bioactive compounds isolated from fruiting bodies and mycelia of this fungus. It has also been found to inhibit platelet aggregation, and to lower blood pressure (via inhibition of angiotensin-converting enzyme), cholesterol and blood sugar. Laboratory studies have shown anti-neoplastic effects of fungal extracts or isolated compounds against some types of cancer. In an animal model, Reishi has been reported to prevent cancer metastasis, with potency comparable to Lentinan from shiitake mushrooms. The mechanisms by which Reishi affect cancer may target different stages of cancer development include: 1) inhibition of angiogenesis (formation of new, tumor-induced blood vessels created to supply nutrients to the tumor) mediated by cytokines, 2) cytotoxicity, 3) inhibition of migration of the cancer cells and metastasis, and 4) inducing and enhancing apoptosis of tumor cells. Besides effects on mammalian physiology, Reishiis reported to have anti-bacterial and anti-viral activities. Reishi is reported to exhibit direct anti-viral effects with the following viruses: HSV-1, HSV-2, and influenza.

Agaricus blazei is an edible mushroom native to Brazil and cultivated in Japan and the USA for its medicinal uses. It has been used to treat arteriosclerosis, hepatitis, hyperlipidemia, diabetes, dermatitis, and cancer. In vitro experiments and studies done in mice have shown that Agaricus has immunomodulatory, antitumor, and antimutagenic properties. The polysaccharides and anti-angiogenic compounds present in Agaricus are thought to be responsible for its antitumor properties. Such effects are believed to be exerted by immunopotentiation or direct inhibition of angiogenesis. A recent randomized study showed that oral administration of Agaricus extract improved the natural killer cell activity and quality of life in gynecological cancer patients undergoing chemotherapy. Agaricus was also shown to have antidiabetic effects in vitro and in animal studies. In addition, results from a study done in human subjects with type 2 diabetes suggest benefits of Agaricus extract in improving insulin resistance, and a pilot study indicates that Agaricus extract may reduce weight, BMI, body fat, and serum glucose and cholesterol levels in healthy individuals.

AHCC as a Component of Immune-Assist™ Daily Formula

AHCC is produced by from the enzymatic action of vegetable sources with mycelial extracts from several different mushrooms. There is about four times more AHCC in each dose of Immune-Assist™ than there is in other AHCC products on the market.

AHCC is a food substance that contains a broad range of polysaccharides. It is believed that a special polysaccharide with a molecular weight of about 5,000 and an alpha 1,4 glucan linkage in this mushroom extract is primarily responsible for the powerful immune enhancing effects on natural killer cells. A heavier polysaccharide in the extract appears to have a powerful stimulating effect on macrophages which, in turn, further stimulates the immune system including a number of cytokines (Interleukin-2, Interleukin-12, Tumor Necrosis Factor [TNF], and Interferon).  Furthermore, some research has indicated that components of AHCC may have direct cytotoxic effects on cancer cells and prevent metastases from occurring.

Natural Killer Cells

The human immune system is comprised of more than 130 subsets of white blood cells. Natural Killer (NK) cells make up roughly 15% of all human white blood cells. They provide the first line of defense for dealing with any form of invasion to the body. Each NK cell contains several small granules that act as chemical destroyers. Once an NK cell has recognized a cancer cell, for example, it attaches itself to the cell’s outer membrane and injects these granules directly into the interior of the cell. The granules then destroy the cancer cell within five minutes. The undamaged NK cell then moves on to other cancer cells and repeats the process. When the immune system is particularly strong, active NK cells will often take on more than one cancer cells or other infected cells at the same time.

NK Cell Activity, Not Number, Determines Immune System Strength

Unlike other white blood cells, inadequate numbers of NK cells are very rarely a problem. Instead, it is the activity of the cells that generally determines whether one is sick or healthy. As long as the NK cells are active, everything remains under control. If NK cells lose their ability to either recognize or destroy the invader, however, the situation can deteriorate rapidly. In AIDS and cancer patients, NK cell activity is probably the primary criteria for estimating the chances of survival. It’s commonly accepted that when NK cells cease to function, the end is near.

In addition, research has now confirmed that individuals with low NK cell activity are significantly more susceptible to autoimmune diseases, chronic fatigue syndrome, viral infections and the development of cancerous tumors.

Doctors can test NK cell activity with a test called the NK cell function test. Basically, a blood sample is taken from the patient and placed in a vial containing live tumor cells. After four hours, a count is taken to determine what percentage of the cancer cells have been destroyed by the NK cells. The higher the percentage, the more active the cells. This test is referred to as the 4 hour Chromium-release assay. Your doctor can order the test from Immune Sciences Lab in Beverly Hills, CA at 310-657-1077.

How IMMUNE-ASSIST™ Increases NK Cell Activity and Immunity

The capacity of Immune-Assist™ to boost NK activity and overall immunity appears to stem from the following:

1) Immune-Assist™ increases the number of explosive granules in NK cells. The more granules an NK cell carries, the more cancer and virus-infected cells it can destroy,

2) Oral ingestion of Immune-Assist™ can increase NK activity as much as 300% (or even higher),

3) It increases interferon (IFN) levels. Interferon is another potent compound produced by the body that both inhibits the replication of viruses and other parasites and increases NK cell activity,

4) Immune-Assist™ increases the formation of Tumor Necrosis Factors (TNFs). TNFs are a group of proteins that help destroy cancer cells,

5) It increases number and the activity of other lymphocytes, especially T-cells (up to 200%) and macrophages,

6) It stimulates cytokine (IL-2, IL-12, TNF, and IFN) production, which stimulates immune function.

Applications for Immune-Assist™

Applications for Immune Assist™ include: 1) recurrent infections, such as colds, flu, and parasites, 2) gum disease, 3) heart disease, 4) peptic ulcer, 5) cancers, 6) slow healing wounds, 7) digestive problems, 8) AIDS, 9) hepatitis, 10) multiple sclerosis, and 11) autoimmune illnesses. Immune Assist™ has not exhibited side effects and is completely non-toxic even after years of use at therapeutic levels.

Owing to its tremendous immune enhancing effects, Immune-Assist™ is likely to be of significant benefit to individuals suffering from a wide range of conditions. Impaired immunity is a result of a wide range of poor lifestyle habits including high stress levels, exposure to high levels of toxins, and poor nutritional status.  As such individuals in the following categories could also benefit from Immune Assist™:

  • Individuals who constantly work with paint (artists, house painters, etc)
  • Chemical and refinery workers and others exposed to heavy doses of toxic chemicals
  • Heavy smokers
  • Heavy drinkers
  • Individuals with gum disease
  • Individuals with peptic ulcers
  • Individuals with prostate infections
  • Individuals with chronic fatigue syndrome
  • Individuals with diabetes
  • Individuals with heart disease
  • Individuals experiencing autoimmune deficiencies (multiple sclerosis, lupus, rheumatoid arthritis)
  • Individuals with recurrent infections, such as colds, flu, yeast, and parasites
  • Individuals whose families exhibit a significant history of cancer
  • Individuals with slow healing wounds

Immune-Assist™ Dosages

Immune AssistThe dosages used in studies are scientifically based on repeated NK cell activity tests. As such, they are consistent and easy to follow. They fall into two types:

1) For cancer, HIV or other life-threatening condition, take three grams per day for two-to-four weeks, then one gram per day until the problem is resolved. Some people continue to take the maintenance dosage even after the problem has been resolved, while others stop taking it and resume if the problem returns. In rare cases taking as much as six grams daily was necessary.

2) As a form of prevention take one gram per day.

In all of the studies, it has been found that taking 3 grams a day resulted in a dramatic increase in NK cell activity within one to two weeks. At the lower dosage of only one gram per day, the same activity wasn’t reached until about four weeks. Thus, the initial heavy doses of three grams per day.  Even after the dosage is dropped back to one gram per day, NK cell activity will continue to increase.  It is best to take the Immune-Assist™ capsules with meals in divided doses.  For example, when taking three grams per day (which works out to six 500 mg capsules), two capsules can be taken with each meal. When you reduce the dosage down to one gram a day (two capsules), you can take one capsule at breakfast and one at dinner.


The importance of a strong, adaptable immune system cannot be underestimated, especially in the context of building (or rebuilding) health and for successful rejuvenation. While there are other useful immune building supplements (e.g., echinacea, garlic, olive leaf extract), Immune Assist™ is highly effective for boosting immunity as part of a complete program for rejuvenation.

Learn more about Immune-Assist™ on the HPDI website.


1) Healing Mushrooms by Dr. Georges Halpern, MD, PhD., 2007, https://www.academia.edu/20332538/Healing_Mushrooms_by_Georges_Halpern

2) Medicinal Mushrooms: their Therapeutic Properties and Current Medical Usage with Special Emphasis on Cancer Treatments. 2001

Authors: JOHN E SMITH BSc MSc PhD DSc FIBiol FRSE Emeritus Professor of Applied Microbiology, University of Strathclyde Chief Scientific Officer, MycoBiotech Ltd, Singapore. NEIL J ROWAN BSc MSc PhD MIBiol MIFST Lecturer, Department of Bioscience, University of Strathclyde, RICHARD SULLIVAN BSc MD PhD Head of Clinical Programmes, Cancer Research UK.

To download this book go here:

3) Anti-Cancer Properties: A peer-reviewed article by Dr. Solomon Wasser of University of Haifa, Israel: Medicinal mushrooms as a source of antitumor and immunomodulating polysaccharides