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What I’d Really Love to Tell You About the Methylation Cycle

Dr. Hank Liers, PhD geneticsI previously published “Homocysteine Genetics – Coenzyme B Vitamins” in which I considered in-depth how homocysteine (an intermediate chemical in the Methylation Cycle) is formed from methionine, how genetics affects the metabolic pathways, and how B vitamins are used in metabolic pathways. I also wrote “Folate Ingredients – Folinic Acid & 5-MTHF” which discussed how coenzyme folate vitamins are far superior to the synthetic folic acid form. In today’s article, I take a broader view of the topic that encompasses the Methylation Cycle, genetics, and B vitamins.

THE METHYLATION CYCLE

The Methylation Cycle is considered to be one of the most important metabolic pathways in the human body. Its most important function is to provide methyl groups via SAM (S-adenosyl methionine) to hundreds of different body substrates. Methylation is continually occurring in the body, transforming many millions of molecules throughout the body every second. Molecules receive methyl groups, then separate and recombine continuously, transforming and reforming constantly in the ongoing process of life!

As a reminder of the pathways involved in the Methylation Cycle, the following figure provides a flow chart showing the details.

 

Methylation Cycle

Figure 1. Metabolic Pathways in Methylation Cycle

A key purpose of this cycle is to provide methyl groups (CH3) needed by a broad range of of body functions (over 200 different functions). Examples include:

  1. Influences the genetic expression that parents give their children and helps guide the development of the embryo.
  2. Is needed by the nervous system to produce neurotransmitters and maintain the nerves.
  3. Mobilizes fats and cholesterol so they do not accumulate where they are harmful, such as the arteries and liver.
  4. Regulates hormones, including, estrogen, adrenaline, and melatonin.
  5. Detoxifies harmful chemicals and histamine a prime substance involved in inflammation.
  6. Helps repair damaged proteins in the cells so they can function properly.
  7. Protects the DNA in the genome (genetic code) to reduce the chances of mutation.
  8. Creates antioxidants used in the antioxidant defense system.

DESCRIPTION OF PATHWAYS WITHIN THE METHYLATION CYCLE

The overall flow of the Methylation Cycle begins with dietary methionine (an essential amino acid) which combines with ATP (adenosine triphosphate – body energy) to form SAM (S-adenosyl methionine) – the common cosubstrate involved in methyl group transfers, transsulfuration, and aminopropylation. When SAM transfers a methyl group to a body chemical the residue from this reaction leads to the production of homocysteine.

Homocysteine can be converted in the transsulfuration pathway that requires coenzyme vitamin B6 to produce cysteine, glutathione, taurine, and sulfates. These sulfur containing substances provide important antioxidant protection and detoxification functions in the body.

Homocysteine can be converted back to methionine through the betaine (trimethyl glycine) pathway which requires zinc and magnesium. This pathway also requires dietary betaine or choline which the body can convert into betaine.

Also, homocysteine can be converted back to methionine via the remethylation pathway which requires 5-MTHF, coenzyme vitamin B2 and methylcobalamin (B12).

GENETICS

It is important to understand that each of the pathways described above are able to be executed only in the presence of enzymes (shown in blue boxes in the diagram) created by specific genes in your genetic code. For example, Betaine-Homocysteine S-Methyltransferase (BHMT) is the enzyme required in the betaine pathway, Cystathione Beta Synthase (CBS) is the enzyme required in the transsulfuration pathway, and Methylenetetrahydrofolate Reductase (MTHFR) and Methionine Synthase (MS) are enzymes required in the remethylation pathway.

Assuming that you have perfect genetics (no mutations, SNPs, free radical damage, insertions/deletions, etc.), the proper functioning of these pathways are still subjected to the fact that the required vitamins and minerals (vitamin B6, vitamin B2, Folate, vitamin B12, zinc, magnesium, and betaine) need to be provided by your diet or from supplements for the body to function correctly.

In addition, exposure to high levels of toxins from your environment and high levels of stress require that the nutritional needs will be even higher for the pathways to work properly. For example, exposure to high levels of toxins requires that the transsulfuration pathway be more active possibly reducing the amount of available methionine to support necessary methyl transfer reactions.

For these reasons alone the consensus of knowledgeable practitioners is that you should be eating an organic whole foods diet, taking appropriate nutritional supplements, avoiding and eliminating toxins from food, water, and air (living in a clean environment), and avoiding an unduly stressful life. All of these actions fall into the category of Epigenetics which you generally have control over!! Doing these things alone could significantly balance the functioning of your Methylation Cycle and improve your health.

Unfortunately, few people have perfect genetics which often causes the various pathways in the Methylation Cycle to become imbalanced and unable to correct the dysregulation imposed upon the body. For example, the enzyme MTHFR can have heterozygous (single chromosome) genetic variations in up to 50% of certain populations and homozygous genetic variations (both chromosomes) in 10% or more of certain populations.

Some disorders that researchers have associated with MTHFR genetic variations include:

  • Alzheimer’s disease
  • Asthma
  • Atherosclerosis
  • Autism
  • Bipolar disorder
  • Bladder issues
  • Blood clots
  • Breast problems
  • Chemical sensitivity
  • Chronic fatigue syndrome
  • Down syndrome
  • Epilepsy
  • Fibromyalgia
  • Gastric problems
  • Glaucoma
  • Heart murmurs
  • High blood pressure
  • Irritable bowel syndrome
  • Leukemia
  • Male infertility
  • Methotrexate toxicity
  • Migraines with aura
  • Multiple sclerosis
  • Myocardial infarction
  • Nitrous oxide toxicity
  • Parkinson’s disease
  • Pulmonary embolisms
  • Schizophrenia
  • Stroke
  • Thyroid issues
  • Unexplained neurologic disease
  • Vascular dementia

This extensive list is highly significant and tells us that it is very important to have genetic testing done for the genes/enzymes in the Methylation Cycle pathway. I prefer the BodySync genetic test which evaluates the key Methylation Cycle genes plus many other important genes in a single test.

B VITAMINS AND MINERALS

We are strong believers that everyone should start their nutritional program by eating a balanced, organic, whole foods diet. We have been doing this ourselves for the past 30 years. Unfortunately, only a small percentage of people follow this advice and in most cases this leads to poor nutritional status that does not adequately support the body’s needs. This is especially true with respect to obtaining the nutrients needed to support the Methylation Cycle.

Nine of our family members and associates have taken the BodySync genetic test which evaluates the condition of 45 different enzymes including CBS, MTHFR (2 variations), MTR (related to B12 and 5-MTHF as they relate to methionine synthase – MS), and MTRR (related to maintaining B12 levels needed by the MTR enzyme). In every case the results showed at least 2 and up to 4 enzymes had genetic variations. These results indicate that the nutritional requirements for folate as 5-MTHF, vitamin B12 as methylcobalamin, vitamin B6, vitamin B2, magnesium and zinc will likely be significantly greater than normal.

Given the above information, it seems essential for good health to take nutritional supplements that provide the important nutrients. Below I will discuss various formulas that I have developed and refined over many years that are useful especially for the Methylation Cycle.

Please note that Health Products Distributors, Inc. (HPDI) is the preferred supplier of nutritional supplements by the BodySync genetic testing company.

MULTIVITAMINS

When looking at the total needs the body has for nutrients that the body does not produce, including fat soluble vitamins (A, D (some), E, K1 and K2), vitamin C, B vitamins (B1, B2, B3, B5, B6, folate, B12, biotin, choline, and inositol), minerals (Ca, Mg, Zn, Se, Cu, Mn, Cr, Mo, K, boron, and vanadium), and betaine it only seems wise to include as a top priority a Multivitamin that includes all of these in what I term therapeutic amounts (carefully selected after evaluating thousands of research studies carried out over many years.)

In this context, it is important to recognize that every enzymatic reaction in the body requires mineral cofactors in order to carry out its function. A good multivitamin provides many of these required minerals.

Additionally, the multivitamin should contain ingredient forms that research has confirmed to be the most absorbable and usable by the body. These include coenzyme B vitamins, Krebs cycle (citrate, alpha-ketoglutarate, succinate, fumarate, & malate) minerals, and amino acid chelates.

In the context of supporting the Methylation Cycle we are looking for specific forms and amounts of B vitamins that can adequately provide the body’s needs. The means that there should be coenzyme folate as 5-MTHF of at least 400 mcg, coenzyme vitamin B-12 as methylcobalamin of at least 200 mcg, Vitamin B6 (including significant amounts of pyridoxal 5′ phosphate) of at least 40 mg, and Vitamin B2 (including significant amounts of riboflavin 5′ phosphate) of at least 25 mg. In addition, magnesium (100 mg) and zinc (at least 20 mg) should be provided.

Please note that the body’s requirements for magnesium is generally accepted by nutritional experts to be higher than 400 mg daily (and as high as 1,000 mg daily). For this reason we generally recommend that a person take supplemental magnesium (such as HPDI’s MYO-MAG) at levels over 400 mg daily.

The two multivitamin formulas Health Products Distributors provides for adults that meet these requirements (and more) are the Hank & Brian’s Mighty Multi-Vite and Multi Two (in both capsule and tablet forms). Click on the bottles below for technical details.

Hank & Brian's Mighty Multi-Vite multivitamin methylation cycle

Multi Two Caps or Tablets methylation cycle

B COMPLEX

In situations where significant genetic variations are present it may be wise to add a B COMPLEX supplement to the MULTIVITAMIN to provide even larger amounts of the needed B vitamins. HPDI provides a B-Complex-50 product that includes significant amounts of coenzyme forms and contains 50 mg of Vitamin B1, 50 mg of Vitamin B2, 100 mg of Vitamin B3, 50 mg of Vitamin B6, 500 mcg of coenzyme folate (both folinic acid and 5-MTHF), 100 mcg of B12 (both methylcobalamin and hydroxocobalmin), 50 mg of Vitamin B5 (pantothenic acid), 500 mg of Biotin, 50 mg of choline, and 50 mg of inositol. Click on the bottle below for technical details.

B-Complex-50 full spectrum B vitamins with coenzyme forms methylation cycle

FOLATE AS 5-MTHF

In situations where an inadequate diet is present and genetic testing indicates an MTHFR variation (especially a homozygous variation) Health Products Distributors provides a 5-MTHF folate supplement that easily absorbs into the body and can be directly used in combination with Vitamin B12 to convert homocysteine to methionine. Click on the bottle below for technical details.

5-MTHF 1 mg in veggie cap methylation cycle

5-MTHF 1 mg in veggie cap

B-12 as METHYLCOBALAMIN

It is often the case for older patients and vegetarians that Vitamin B12 is deficient. In these cases it is wise to supplement with a significant amount of methylcobalamin to ensure that the Methylation Cycle has sufficient to effectively convert homocysteine into methionine. Health Products Distributors Vitamin B12 contains 5 mg of methylcobalamin in sublingual lozenge form that supports excellent absorption even if swallowed and absorbed by diffusion. Click on the bottle below for technical details.

Vitamin B-12 5 mg methylcobalamin sublingual lozenge methylation cycle

Vitamin B-12 – 5 mg Methylcobalamin sublingual lozenge.

MINERALS

Magnesium and zinc are two important minerals used in the betaine pathway of the Methylation Cycle in which homocysteine is converted back to methionine.

In the body magnesium is involved in more than 400 essential metabolic reactions and is required by the adenosine triphosphate (ATP)-synthesizing protein in mitochondria. ATP, the molecule that provides energy for almost all metabolic processes, exists primarily as a complex with magnesium (MgATP). Therefore, it also is involved in converting methionine to SAM.

Over 300 different enzymes depend on zinc for their ability to catalyze vital chemical reactions. Zinc-dependent enzymes can be found in all known classes of enzymes.

Health Products Distributors provides 100 mg magnesium/vcap in its MYO-MAG supplement which is especially important in increasing ATP in the Krebs Cycle. This product also contains vitamin B1, vitamin B2, and vitamin B6 with substantial amounts of coenzyme forms and manganese. Click on the bottle below for technical details.

MYO-MAG with 100 mg magnesium per serving key B vitamins methylation cycle

MYO-MAG with 100 mg magnesium per serving and key B vitamins.

Health Products Distributors provides 25 mg zinc/serving in its Double Zinc Plus supplement. This formula provides zinc in the picolinate and citrate forms as well as 3 mg of P5P (coenzyme B6). Click on the bottle below for technical details.

Double Zinc Plus supplement with P5P and 25 mg zinc methylation cycle

Double Zinc Plus supplement with P5P and 25 mg zinc

SUMMARY

The Methylation Cycle is recognized as one of the most important metabolic pathways in the human body. When not properly supported by key B vitamins and minerals, the Methylation Cycle can become severely imbalanced which can lead to a very wide range of poor health conditions. Furthermore, genetic variations in the genes that produce important enzymes allowing the Methylation Cycle to function correctly lead to even further imbalances and greater possibility for conditions of poor health.

In this article, I have provided insight into how the Methylation Cycle works and how it can be significantly supported by lifestyle changes regarding diet and environment (Epigenetics) and by specific B vitamins and mineral supplements that I have developed over many years. In addition, we have shown that knowledge gained from genetic testing can further provide a critical understanding of your specific needs so that your health can be optimized.

RELATED HPDI BLOG ARTICLES

Homocysteine Genetics – Coenzyme B Vitamins

 

MULTIVITAMINS – WHY YOU NEED THEM

Fred Liers PhD multivitaminsMultivitamins are the most important of the basic or foundational supplements providing nutrients essential for health and wellness. Because if there is a single nutritional supplement everyone should take, a multivitamin is it.

But it can’t be just any multivitamin. The best multivitamins are complete, high-potency, high-quality, high-purity, provide a complete range of essential vitamins and minerals, and contain advanced forms—more about advanced forms later.

The purpose of taking a high-potency multivitamin not only is to provide the body with amounts and forms of nutrients meeting minimum requirements for avoiding deficiency conditions, but also sufficient levels of nutrients that can support optimal health. Because vitamins levels for optimal health are NOT the same as levels required to avoid deficiency conditions.

MORE THAN DAILY ALLOWANCES

While 40% of Americans say they take a multivitamin daily, how many actually obtain all the nutrients they need for optimal health from taking it? Practically no one. Why?

Because basic “recommended daily amounts” (100% of daily allowance) typically found in multivitamins are based on models for disease prevention. That is, these are minimum levels indicated to avoid conditions like Pellagra (caused by vitamin B3 deficiency), Beriberi (caused by vitamin B1 deficiency), or Rickets (caused by vitamin D deficiency), for example. Nutrient fortification of foods by law has mostly eradicated those conditions. But, as noted, minimum recommended amounts are not the amounts required for optimal health.

The best multivitamin supplements therefore do not provide just 100% of a recommended daily amount of a certain nutrient, but far higher amounts. That is for truly optimal health, high-potency is a must in multivitamins. One of the main reasons for this is “biochemical individuality.” While most people fall within a certain range in terms of their needs for a specific nutrient, the overall range (or bell curve) may be quite large. Your needs may be greater.

Another, related reason is genetics. If you are heterozygous for a gene that requires a specific nutrient, then you may already be at a disadvantage for assimilating or processing it. If you are homozygous, then not having sufficient amounts of a nutrient can have much larger, adverse consequences.

For any given nutrient, then, your needs may be higher or significantly higher than other people’s needs. The best way to guarantee your needs are met is to ensure you consume larger amounts. That is, a high-potency multivitamin providing levels of nutrients well above the minimum amounts established to avoid deficiency.

MULTIVITAMINS ARE SAFE, LOW COST,
AND EFFECTIVE

High-potency multivitamins work well because vitamins—at least at the levels we are talking about here—are non-toxic, safe, and well-tolerated. Add to the safety of vitamins their relatively low cost (especially compared to pharmaceuticals) that solidifies the case for high-potency multivitamins as a virtual “no-brainer” for supporting good health.

That is the basic rationale for why you need a high-quality, high-potency multivitamin. There are many other reasons. Such reasons include the fact that diet alone is usually not enough to provide the levels of basic nutrients you need.

DIET ALONE IS USUALLY INSUFFICIENT FOR OPTIMAL LEVELS OF NUTRIENTS

Diet alone could perhaps be sufficient if foods were nutrient-dense and you consumed enough of them. But foods today are typically not nutrient-dense given how modern agriculture has stripped the soils of essential nutrients. Herbicides and pesticides then poison foods. And the widely used glyphosate herbicide (RoundUp) actually depletes nutrients in foods by blocking their uptake in plants leading to further depletion in crop foods. Food processing then strips out additional nutrients. Get the picture?

On top of all this, your requirements for nutrients are increased by factors such as pollution and chemical exposures (and greater stress on detoxification organs), emotional stress, immune stresses (like fighting off colds or flu), and even free-radical stress caused by electromagnetic fields (EMFs) such as mobile phone and Wi-Fi exposures. In many cases, various stresses and environmental exposures put a greater burden on your antioxidant defense systems by subjecting you to free-radical attack. This is just the beginning.

Assuming your diet were “perfect” (which most likely it is not), your needs for various nutrients will vary depending on your levels of exposure to stresses (emotional, chemical, electromagnetic, etc.). This means that as your needs for extra nutrients rise to combat these stresses, the simplest and best way to meet those needs is through consuming additional, supplemental amounts of nutrients—to successfully meet those needs. Otherwise, having only minimal amounts (i.e., daily values created to avoid deficiency diseases) means your need for higher amounts will not be met.

IF YOU DO NOTHING ELSE, TAKE A HIGH-QUALITY MULTIVITAMIN

A multivitamin can meet those additional needs, or at least start meeting them. In fact, a multivitamin is the best “first line of defense.” In the HPDI system, a multivitamin is just one of six foundational supplements—but it “first among equals” and therefore the very first supplement we recommend. This means that if you do nothing else, then take a multivitamin.

Need another good reason to make a multivitamin? Again, genetics. HPDI has teamed up with Bodysync, the developer of Nutrisync genetic tests (available to HPDI resellers on the reseller website and to retail customers by phone) that offers testing for health-related genetic variations in your DNA.

Among the first things we realized after analyzing Nutrsync genetic test results is that many genetic variants that may cause problems with uptake of certain nutrients—or that require additional amounts of nutrients—can be partly or wholly mitigated by taking a high-potency multivitamin. This is not true in every case, but surprisingly the nutrients provided in a quality multivitamin can be a strong defense in this regard.

Another thing we noticed is that the results of almost everyone taking the Nutrisync test exhibit certain genetic weaknesses that would benefit from a multivitamin. Another “no brainer” observation that may not have been so obvious beforehand, yet which corresponds with what we have been recommending to clients for decades: Take a multivitamin!

People may not realize that optimal health is within reach. Taking a high-potency multivitamin daily is a major first step toward achieving it.

BENEFITS OF A HIGH-QUALITY, HIGH-POTENCY MULTIVITAMIN

Considering all the factors involved in optimal nutrition—and how important nutrition is to health—it is remarkable to think that your health can be well maintained or dramatically improved simply by taking a high-potency multivitamin. Yet, that is a fact. And

• Ensures complete nutrition by providing a wide-range of nutrients to supplement those obtainable by diet
• Provides optimal levels of nutrients in a balanced way
• Guards against deficiencies of particular nutrients
• Protects against nutrient depletion caused by increased needs for nutrients (e.g., various stresses or periods of inadequate intake).
• Helps you fulfill genetic potential by supplying nutrients required for optimal genetic expression and for overcoming adverse genetic factors
• Safe, low cost, and effective means to support good health

BENEFITS OF HPDI MULTIVITAMINS

HPDI formulates and sells some of the highest-quality, high-potency multivitamins available. Many of our customers are health professionals who supply their clients with our multivitamins—because health professionals demand supplements proven to be effective. And they know the difference!

• HPDI multivitamins provide a complete range of nutrients, including vitamins, minerals, cofactors, and phytonutrients
• Therapeutic levels of nutrients in amounts necessary for health—typically greater than daily values
• Nutrients balanced so as not to provide too little or too much of any given nutrient
• High-purity with minimal excipients, and avoidance of harmful excipients
• Advanced forms (including coenzyme vitamins) for optimal uptake, transport, and utilization
• Inclusion of coenzyme form B vitamins
• Inclusion of potent antioxidants and Nrf2 activators
• Formulated by Hank Liers, PhD, designer of supplements for 30 years
• Vegetarian capsules

HPDI MULTIVITAMINS

Health Products Distributors, Inc. (HPDI) currently offers five multivitamins, including Mighty Multi-Vite!, Multi Two (tabs and caps), Mini Multi, and Chewable Kids Mighty-Multi. Each multivitamin is formulated for a specific purpose:

Multi Two and Mighty Multi-Vite! are flagship multivitamins with advanced forms. Multi Two offers higher levels of B vitamins, whereas Mighty Multi-Vite! provides relatively more antioxidants and phytonutrients.

Mini Multi is formulated for chemically and environmentally sensitive individuals or those who seek ultra-high purity. Mini Multi contains no excipients (i.e., additives or fillers), and provides 100% coenzyme vitamins.

Chewable Kids Mighty-Multi! tastes great and includes xylitol to prevent cavities. Kids love this chewable formula, but it is also scalable for adults. This formula is most similar to Mighty Multi-Vite! in terms its nutrient content.

HPDI multivitamins

HPDI multivitamins: Multi Two (caps and tabs), Mighty Multi-Vite!, Mini Multi, and Chewable Kids Mighty-Multi.

HPDI MULTIVITAMINS IN DEPTH

1. MIGHTY MULTI-VITE!

HANK & BRIAN’S™ MIGHTY MULTI-VITE! (or as we often call it, the “Mighty Multi”) is perhaps the premier HPDI multivitamin, and definitely among the flagship multivitamins we offer. I personally take this one most of the time. It is in the “Hank & Brian’s” line, which generally are among our best products.

Mighty Multi incorporates the latest nutritional research in a complete formula that combines the highest-quality, most assimilable forms of vitamins and minerals along with advanced herbal nutrition.

Mighty Multi-Vite! is an advanced, cutting-edge multivitamin that is a leader within HPDI’s line of foundational supplements. This formula exhibits superior performance with respect to supporting optimal health, and is among the world’s most sophisticated multivitamins. Mighty Multi-Vite! works synergistically with other foundational supplements to help sustain maximum health, vitality, and promote longevity.

Now with these 7 absolutely essential improvements:

  • Now in an ultra-pure vegetarian capsule
  • Vitamin B12 is now in the methylcobalamin coenzyme form
  • Turmeric is now in an extract form with 95% curcuminoids – a powerful Nrf2 activator
  • Now uses broccoli sprouts powder containing sulforaphane – another powerful Nrf2 activator
  • Contains both Vitamin K1 and Vitamin K2 (as MK-7)
  • Contains the best coenzyme form of folate – L-5-MTHF
  • Contains no magnesium stearate
Mighty Multi multivitamins

Mighty Multi-Vite! is an HPDI flagship multivitamin offering special nutrients for antioxidant protection.

MIGHTY MULTI-VITE! BENEFITS

COMPLETE, BALANCED ESSENTIAL NUTRITION – Provides a full spectrum of nutrients exceptionally well balanced for creating and maintaining optimal health. Mighty Multi-Vite! offers all the most important vitamins along with minerals, cofactors, antioxidants, and herbs.

RAPID, EASY ASSIMILATION – Incorporates the most bioavailable vitamin and mineral carriers most easily recognized and rapidly assimilated by your body. In addition, the formula uses multiple forms of mineral carriers to ensure assimilation. In addition, the capsule form speeds uptake because it does not require time for the body to break it down (unlike tablets).

ENERGIZING – Includes coenzyme form vitamins and Krebs Cycle bionutrients that work with your body to create super high energy levels. Provides significant levels of B vitamins (especially coenzyme B vitamins) known for boosting energy, supporting the body during times of stress, nerve function, heart function, and for working together with dietary RNA (found in Rejuvenate!™ superfoods) to produce significant therapeutic effects.

FOUNDATIONAL SUPPLEMENT – For creating health and establishing a complete supplement program. Providing excellent foundational nutrition, Mighty Multi-Vite! is designed to work synergistically with other foundational formulas for maximum health benefits.

In addition to the newest improvements, Mighty Multi-Vite! features:

  • A full spectrum of B-complex vitamins, most in coenzyme forms, as well as more conventional forms. Includes Vitamin B1 as thiamin HCl and thiamin diphosphate, Vitamin B2 as riboflavin and riboflavin-5′-phosphate, Vitamin B3 as niacinamide and niacin, Vitamin B5 as pantothenic acid, Vitamin B6 as pyridoxine HCl and pyridoxal-5′-phosphate, folate as L-5-methyltetrahydrofolate (L-5-MTHF), Vitamin B12 as methylcobalamin, and biotin.
  • All of the most absorbable and usable forms of the fat-soluble vitamin group, including Vitamin A (as beta-carotene), Vitamin E (as d-alpha tocopherol succinate), Vitamin D-3 (as cholecalciferol), Vitamin K (as phytonadione and MK-7).
  • A complete and balanced supply of the most abundant carotenoids found in the body, including beta- and alpha-carotene, as well as lycopene and lutein.
  • A variety of the best-known herbal preparations, including quercetin, grape extract, turmeric (95% curcuminoids), broccoli sprouts powder, octacosanol from policosanol, and stevia.
  • All of the known essential minerals in forms readily absorbed and recognized by the body including calcium, magnesium, potassium, zinc, manganese, boron, copper, chromium, molybdenum, vanadium, and selenium.
  • Mineral carriers such as ascorbates, Krebs cycle bionutrients and amino acids providing the body with important metabolic substrates and vitamins, including citrate, succinate, alpha-ketoglutarate, fumarate, malate, glycinate, aspartate, sebacate, and Vitamin C.
  • Includes the important sulfur-containing amino acid N-Acetyl-L-Cysteine to support the body’s antioxidant and detoxification systems and betaine HCl to support digestive processes.
  • Includes choline and inositol which play a crucial role in all of the cell membranes of the body, in brain function, and in liver function.
  • Exclusion of the prooxidant minerals of iron and iodine which can lead to excessive free-radical production and PABA that sometimes adversely affects brain function in some individuals. Note: we sell iodine as separate formulas.
  • Capsule form that ensures the maximum absorption of ingredients.
  • Four-per-day full dosage that allows for partial dosing for children, seniors, and pets.
  • Vegetarian formula – including capsule.
  • Capsule contents designed to smell and taste good to adults and children when emptied into smoothies, drinks, and foods. This allows greater flexibility of use.
  • Exclusion of ingredients such as wheat, gluten, dairy, corn, soy, and egg having well-known antigenic properties and that may be associated with allergy or delayed hypersensitivity reactions.
  • A minimum of excipients, fillers, lubricants, etc. having deleterious effects in some individuals. No GMOs.

As I mentioned previously, the Mighty Multi is uniquely advanced it that it provides special antioxidant ingredients like turmeric, grape extract, and broccoli sprouts powder.

2 & 3. MULTI TWO (CAPS & TABS)

MULTI TWO is another HPDI flagship multivitamin. We recommend it especially for individuals who prefer more B vitamins built into their multivitamin. Yet, it offers somewhat fewer antioxidant nutrients.

MULTI TWO is a pure, complete, biochemically formulated multivitamin supplement with minerals and cofactors. It dissolves readily and is highly bioavailable. All ingredients are sourced for purity and carefully selected to avoid common food allergens. MULTI TWO is available in tablet and vegetarian capsule forms.

MULTI TWO is among HPDI’s most popular multivitamins, providing top-notch quality, high-purity, advanced design and formulation, and exceptional value for the price.

The formula comes in tablet or capsule forms. The tablet is suitable for vegetarians, only containing plant fiber to bind components, further eliminating chemical contaminants. The capsule form now is also vegetarian. The capsules have a four-per-day full dosage allowing for partial dosing for children, seniors, and pets. Note: the capsule’s powder contents taste quite good to most people, so it can be added to sippy cups, blender drinks, smoothies, pet foods, etc.

MULTI TWO is one of HPDI’s foundational multivitamin supplements in our health recovery and maintenance programs. A foundational program of supplements includes a multivitamin, essential fatty acids, a Vitamin C formula, and a Rejuvenate!™ superfood.

multivitamins

Multi Two Caps are among HPDI’s premier therapeutic-grade multivitamin formulas providing a complete range of nutrients.

MULTI TWO OFFERS UNIQUE BENEFITS

  • COMPLETE, BALANCED FOUNDATIONAL NUTRITION. Full-Spectrum of Nutrients Exceptionally Balanced for Supporting Your Health. Foundational Formula Ideal for Providing Essential Foundational Nutrition. A high-quality multivitamin is the foundation (i.e., core) for a complete nutritional supplement program.
  • RAPID AND EFFECTIVE ASSIMILATION. Incorporates Bioavailable Vitamin and Mineral Carriers Your Body Recognizes and Can Assimilate Immediately. Plus, Multiple Carriers Ensure Assimilation. Tablet or Capsule Forms Rapidly Assimilated.
  • POWERFULLY ENERGIZING. Includes Coenzyme Form Vitamins and Krebs Cycle Bionutrients that work with your body to create high energy levels. Full-Spectrum Essential Nutrients Needed For Building, Supporting, and Maintaining Excellent Health.
  • HIGH PURITY. One of the Purest Available Supplements. Carefully Designed To Exclude Common Allergens, and Exclude or Minimize Excipients, Additives, and Fillers.
  • TABLET AND VEGETARIAN CAPSULE FORMS. We Offer Both Forms Giving You More Choice. Take Your Pick.
  • FOUNDATIONAL SUPPLEMENT. Providing solid foundational nutrition, MULTI TWO functions most effectively when used in conjunction with other foundational formulas, especially Vitamin C formulas (including ULTIMATE PROTECTOR™ and PRO-C™), Essential Fatty Acid formulas (including Omega Plus and Essential Fats Plus E), and REJUVENATE!™ superfoods. These foundational supplements together form the foundation of a complete nutritional supplement program. From here, you can add additional supplements (enhancements and specific condition formulas) addressing your individual needs, i.e., by pinpointing where your body requires additional nutritional support.

MULTI TWO FEATURES

  • A full-spectrum of B-complex vitamins, most in coenzyme forms, as well as more conventional forms. Includes Vitamin B1 as thiamin HCl and thiamin diphosphate, Vitamin B2 as riboflavin and riboflavin 5’-phosphate, Vitamin B3 as niacinamide and niacin, and Vitamin B6 as pyridoxine HCl and pyridoxal 5’-phosphate, folate from calcium folinate and 5-MTHF, Vitamin B12 as methylcobalamin and hydroxocobalamin, and biotin.
  • All of the most absorbable and usable forms of the fat-soluble vitamin group, including Vitamin A (as natural beta-carotene), Vitamin E (as d-alpha tocopherol succinate and mixed tocopherols), Vitamin D3 (as cholecalciferol), and two forms of Vitamin K (K1 as phylloquinone and K2 as menaquinone-7).
  • Effective herbal preparations, including quercetin, grape extract, octacosanol.
  • All of the known essential minerals in forms readily absorbed and recognized by the body including calcium, magnesium, potassium, zinc, manganese, boron, copper, chromium, molybdenum, vanadium, and selenium.
  • Mineral carriers such as ascorbates, Krebs cycle bionutrients, and amino acids providing the body with important metabolic substrates and vitamins, including citrate, succinate, alpha-ketoglutarate, fumarate, malate, glycinate, aspartate, sebacate, and Vitamin C.
  • Includes betaine HCl to support digestive processes.
  • Choline and inositol which play a crucial role in all of the cell membranes of the body, in brain function, and in liver function.
  • Exclusion of the prooxidant minerals of iron and iodine which can lead to excessive free-radical production and PABA that sometimes adversely affects brain function in some individuals.
  • Four-per-day full dosage of capsule form allows for partial dosing for children, seniors, and pets.
  • Tablet and capsule forms are vegetarian (except for pharmaceutical glaze on tablets).
  • Exclusion of ingredients such as wheat, dairy, corn, soy, and egg having well-known antigenic properties and that may be associated with allergy or delayed hypersensitivity reactions. Contains no GMOs.
  • A minimum of excipients, fillers, lubricants, etc. that exert deleterious effects in some individuals.

Multi Two is a great multivitamin and in many ways similar to the Mighty Multi-Vite!. However, Multi Two provides more B vitamins and in the case of certain B vitamins, it provides twice as much as Mighty Multi-Vite!. For anyone who requires plenty of B vitamins and who doesn’t necessarily want to take a separate, standalone B vitamin formula, Multi Two is an ideal multivitamin.

For more information, see the full Multi Two product page (capsules) or the Multi Two product page for tablets.

 

4. MINI MULTI

We call our Mini Multi the “World’s Purest Multivitamin.” This is because it was originally formulated for chemically and/or environmentally sensitive persons. The capsule is smaller than our other multivitamins which easily allows for partial dosing. It also is our only all coenzyme form multivitamin.

MINI MULTI is an ultrapure, biochemically formulated, complete multivitamin supplement that includes essential and trace minerals, and cofactors. MINI MULTI is highly bioavailable and contained in a preservative-free veggie capsule (helping eliminate chemical contaminants). The capsule contains no fillers, flow agents, or any other excipients. Each component is the highest purity.

MINI MULTI is ideal for chemically and environmentally sensitive individuals who require ultra-high purity supplements. The formula is designed by Dr. Hank Liers, who developed it as a ultra-pure formula for sensitive individuals. Yet, anyone can take MINI MULTI to benefit from its ultra-high purity and avoidance of additives, fillers, or other excipients.

Many individuals who take MINI MULTI are not chemically sensitive, but suffer from allergies, sensitive digestive tracts, wish to avoid gelatin capsules, or simply do not enjoy swallowing large capsules (or tablets).

multivitamins

Meet Mini Multi, the world’s purest multivitamin formulated originally for chemically and environmentally sensitive persons.

ADVANCED DESIGN INCLUDES NEARLY 100% COENZYME FORM B VITAMINS

MINI MULTI’s biochemical formulation incorporates the latest research on nutrient transport and interaction to enhance efficient metabolism and includes coenzyme forms of vitamins. The vitamins and minerals in MINI MULTI activate the body’s metabolic machinery, and synergistic cofactors aid absorption, assimilation, utilization, and metabolism of nutrients.

MINI MULTI is among the first multivitamins to provide almost all coenzyme form B vitamins (i.e., all except vitamin B3, which we include as niacinamide). Coenzyme form vitamins are the natural forms best recognized and utilized in the body. For example, MINI MULTI provides folate in the form of folinic acid (a natural form of folate) from calcium folinate and L-5-MTHF (another natural form of folate), rather than the typical and commonly used folic acid, a synthetic form requiring enzymatic processing in the body for utilization. That is, coenzyme vitamins are easier to assimilate (especially for older individuals or those with health conditions that reduce enzyme activity in vivo) and they are immediately recognized and used in the body.

FEATURES AND BENEFITS OF THE HIGHEST PURITY FORMULA AVAILABLE TODAY

  1. The world’s purest multivitamin supplement, proven for more than a decade
  2. Ideal for chemically, environmentally or allergen sensitive individuals, or anyone desiring an ultra-high purity in a nutritional supplement
  3. Highly effective, complete formula includes vitamins, minerals, and cofactors (including powerful antioxidants)
  4. Includes nearly 100% coenzyme form B vitamins for rapid assimilation (all except B3 which is included as niacinamide and B5 which is included as pantothenic acid)
  5. Convenient four-per-day dosage allows easy for partial dosing
  6. Suitable for vegans and vegetarians (veggie capsule)
  7. Suitable for children (i.e., capsule may be opened and emptied into drinks or food)
  8. No additives, fillers, flow agents, or any other excipients!
  9. Nothing artificial or synthetic!
  10. Gluten-free
  11. In fact, MINI MULTI does not contain wheat, rye, oats, corn, barley, gluten, egg, dairy, citrus, yeast, sugar, GMOs, wax, sulfates, phosphates (other than coenzymes), preservatives, fillers, binders, coatings, colorings, or artificial flavorings

MINI MULTI exhibits superior design, technical sophistication, ease of use, and high perfomance. We suggest you try it whether you are sensitive to fillers or flow agents, suffer from allergies due to common additives, wish to avoid artificial ingredients, or simply want the purest multivitamin available.

In this day and age when many individuals suffer from allergies to ingredient sensitivities, Mini Multi represents a choice for the ultimate in high-purity. No excipients means a cleaner supplement option for anyone who may need it.

5. CHEWABLE KIDS MIGHTY-MULTI

HPDI’s KIDS MIGHTY-MULTI! is truly one-of-a-kind. It is most similar to the Mighty Multi-Vite! in terms of the nutrients it provides, including antioxidants. However, it is our only chewable and it tastes great.

KIDS MIGHTY-MULTI! is an advanced chewable multivitamin for children incorporating the latest nutritional research in a tasty, complete formula combining the highest-quality and most usable forms of vitamins, minerals, herbs, and cofactors.

Our children’s multivitamin formula provides optimal levels of basic essential nutrients and thereby is an ideal foundation upon which to build a complete nutritional supplement program. A high-quality multivitamin is the starting-point for building a program uniquely designed to suit to your child’s individual requirements.

We offer KIDS MIGHTY-MULTI! as a “top-of-the-line” children’s formula that tastes great and produces exceptional results. This unique formula very effectively provides children with a solid foundation of nutrients for establishing, building, supporting, and maintaining excellent health during this critical period of their lives.

COMPLETE FORMULA – the most complete children’s formulas available! It provides a full-spectrum of essential nutrients needed for creating, supporting, and maintaining excellent health for your child. It includes natural coenzyme form vitamins and Krebs cycle bionutrients that work with young bodies to provide energy for metabolic processes, healing, and optimal heatlh.

AMAZING TASTE, NATURALLY the most delicious kids multivitamin you’ll ever taste! Flavored with only healthy, natural sweeteners and functional taste enhancers, including mannitol, xylitol, fructooligosaccharides (FOS) (from chicory root), natural fruit flavor, and stevia leaf extract. Most of these taste enhancers actually exhibit other positive benefits in the body (i.e., prebiotic effects, cavity prevention, and antioxidant action). Kids (and adults) love the taste!

BALANCED ESSENTIAL NUTRIENTS – exceptionally balanced nutrients for supporting your child’s health. This is a foundational formula ideal for providing basic nutrients for health. Indeed, a high-quality multivitamin is a basic foundational formula (along with vitamin C and essential fatty acid formulas) in a nutritional supplement program. Our kids’ formula puts your child on the nutritional track he or she deserves right from the start!

“ULTRA PURE”
– excludes common food source allergens (like wheat, corn, soy, or dairy). Also excludes unnecessary excipients, fillers, binders, and additives. Unlike many children’s vitamins, ours contains NO artificial colorings or flavorings, artificial sweeteners (like aspartame, saccharin, or sucralose) or hydrogenated vegetable oils…substances that can have deleterious effects on health (yet are frequently include. Plus, NO sugar and NO GMOs!

RAPID ASSIMILATION
– incorporates bioavailable vitamin and mineral carriers the body recognizes and can assimilate immediately. Plus, multiple carriers ensure assimilation. Chewable form speeds uptake in the body.

FOUNDATIONAL FORMULA – forms the foundation of a complete supplement program for your child. Formulated to work with other foundational formulas, including Vitamin C formulas (like PRO-C™) and essential fatty acid formulas (like Essential Fats plus E) that together form the basis of a complete nutritional supplement program. You can also add specific supplements addressing your individual needs of your child, i.e., by pinpointing where he or she may require additional nutritional support. Such specific supplements might include Allergy Support Plus, Joint Health Formula, or Ultimate Protector™ (super antioxidant & Nrf2 activator formula).

Kids Mighty-Multi is the perfect multivitamin for kids offering appropriate levels of a wide range of important vitamins, minerals, cofactors, and antioxidants.

KIDS MIGHTY-MULTI! FEATURES

• A full-spectrum of B-complex vitamins primarily in coenzyme forms, including Vitamin B1 (as thiamin diphosphate), Vitamin B2 (as riboflavin-5’-phosphate), Vitamin B3 (as niacinamide and niacin), Pantothenic acid), Vitamin B6 (as pyridoxal 5’-phosphate), folate (as 5-MTHF), Vitamin B12 (as methylcobalamin), and Biotin.

• All of the most absorbable and usable forms of the fat-soluble vitamin group, including Vitamin A (as natural beta-carotene), Vitamin E (as d-alpha tocopherol succinate and mixed tocopherols), Vitamin D3 (as cholecalciferol), and Vitamin K (as phylloquinone (K1) and MK-7 (K2)).

• A complete and balanced supply of the most abundant carotenoids found in the body, including Beta-Carotene, Lycopene, and Lutein.

• A variety of the best-known herbal ingredients, including Quercetin, Grape Extract, Turmeric extract, Broccoli Sprouts Powder, and Octacosanol (from policosanol).

• Readily absorbed forms of all essential minerals, including Calcium, Magnesium, Potassium, Zinc, Iron, Manganese, Boron, Copper, Chromium, Molybdenum, Vanadium, and Selenium.

• Easily assimilated mineral carriers, including ascorbates (Vitamin C), Krebs cycle bionutrients (citrate, succinate, alpha-ketoglutarate, fumarate, malate), and amino acids (e.g., glycine, taurine, and aspartic acid) that provide the body with important metabolic substrates and vitamins.

• Sulfur-containing amino acids supporting the body’s detoxification systems.

• Natural taste-enhancing complex of xylitol, mannitol, FOS, and stevia leaf extract. Tasty fruit flavor kids love!

• Therapeutic levels of xylitol helping to prevent cavities.

• Significant levels of choline and inositol that play a crucial role in all cell membranes, and in brain and liver function.

• Betaine HCl to support digestive processes.

• Exclusion of the pro-oxidant mineral iodine that may lead to excessive free radical production and PABA that can adversely affect brain function. We actually prefer the safer and more therapeutic Nascent Iodine over the forms normally found in vitamin formulas.

• Exclusion of substances that have well-known antigenic properties and that may be associated with allergy or delayed hypersensitivity reactions, including wheat, corn, soy, egg, and dairy.

• Minimum of excipients, fillers, or additives (that may have deleterious effects in some individuals).

• Small tablet size allows for weight-dependent dosing (two tablets per 20 lbs body weight)

MORE ABOUT KIDS MIGHTY-MULTI!

A Better, Safer Multivitamin for Kids

The vast majority of children’s vitamins today are decidedly not advanced formulations. They typically provide only minimum amounts (i.e., no more than government mandated daily values) of vitamins, minerals, and other nutrients. In addition, most kids’ vitamin on the market remain filled with sugars and artificial ingredients, including aspartame (a known toxin), artificial colorings, preservatives, hydrogenated oils, and other toxic substances.

Consider what our Kids Mighty-Multi! does NOT contain:

  • Aspartame. There is controversy surrounding this artificial sweetener, which is associated with a variety of neurological problems. In fact, there is widespread consensus that children under six should not use aspartame. We believe no one should consume aspartame at any age!
  • Refined sugars (usually listed as, sucrose, etc.). There is no place for sugar in multivitamins. Sugar in supplements is also dangerous because when coupled with ascorbic acid, it can damage teeth! Chewable kids vitamins containing sugar expose your child’s teeth to double jeopardy.
  • Artificial dyes (FD&C Yellow, Blue, and/or Red). Artificial colors are associated with a wide range of health and behavioral problems. These include carcinogenicity, and contributing to learning problems like ADHD. In addition, FD&C Yellow dye #5 (tartrazine) is one of the main food triggers of asthma attacks.
  • Benzoates, sulfur dioxide, sulfites. These are bad because they are all preservatives that have no business being in a health supplement. They all are known to stimulate allergic reactions.
  • Hydrogenated oils. These are the bad, sticky fats that are found in junk foods and are harmful to your child’s heart. Incredibly, some companies put hydrogenated oils in a children’s vitamin!

As you can see, our children’s chewable multivitamin is not your ordinary kids multivitamin, and it provides all the benefits of our other multivitamins in a tasty chewable format. In fact, many adults take it who prefer a chewable over a capsule or tablet. It is uniquely formulated to be scalable for adults at the dosage of two tablets per 20 lbs body weight.

multivitamins

Chewable Kids Mighty-Multi tastes great, provides advanced forms of nutrients, and scales up for adults.

CONCLUSION: TAKE A MULTIVITAMIN

Multivitamins are the first supplement most people need and should take. Taking a high-potency, high-purity multivitamin daily provides many benefits beyond what you might expect. This includes everything from ensuring against deficiencies to providing amounts necessary for optimal health, and for compensating for greater needs depending on your unique biochemical individuality. Given the overarching safety and relatively low cost of multivitamins, they are best “first defense” in a nutrient-depleted world.

HPDI offers four of the best multivitamins available anywhere, and five if you consider that Multi Two is available in capsules or tablets. So take your pick among them, and be the healthiest you can be.

MULTIVITAMIN RESOURCES

HPDI Multivitamins

Mighty Multi-Vite!

Multi Two (Capsules)

Multi Two (Tablets)

Mini Multi

Kids Mighty-Multi! (Chewable)

ARTICLES & e-BOOKS

“Why You Need Foundational Supplements”

The Need for Foundational Supplements e-book (.pdf)

“Rejuvenation Program Part Four”

“Choosing Supplements for a Complete Nutritional Supplements Program”

Discovering Nutritional Needs Through Advanced Genetic Testing

No Deaths from Vitamins. None. Safety Once Again Confirmed by America’s Largest Database” (Orthomolecular News Service, 2017)

VIDEOS

HPDI Foundational Supplements – VIDEO

Health Products Distributors, Inc.

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HPDI FOUNDATIONAL SUPPLEMENTS – VIDEO

Fred Liers PhD foundational supplements nutritionDo you know HPDI has a foundational supplements system? And that HPDI’s system of Foundational Supplements is part of the comprehensive HPDI supplements system?

Foundational supplements are basic supplements providing essential nutrients that should be the “foundation” of everyone’s daily regimen. They are the foundation of a complete nutritional supplement program. They are the like the base of a pyramid in a complete nutritional supplement program.

All six HPDI foundational supplements are designed to provide a complete range of essential nutrients to complement a healthy diet and lifestyle. They help ensure sufficient levels of nutrients necessary for good health. And they are the first supplements we recommend taking as part of a complete nutritional supplement regimen.

Foundational supplements are the cornerstone in the HPDI supplement system. That is, HPDI offers a three-tiered system of nutritional supplements: Foundational Supplements, Enhancement Formulas, and Specific-Condition Formulas. The three “tiers” combined represent a complete nutritional supplement program. When customized appropriately to meet the needs of individuals, the three tiers of nutritional supplements help create optimal health.

You can visualize the HPDI supplement system as a cone or pyramid having a base of Foundational Supplements ascending toward an apex of Enhancement Formulas and Specific Condition Formulas.

foundational supplements HPDI system

The HPDI Supplement System includes six Foundational Supplements—four primary and two secondary—including multivitamins, vitamin C/antioxidants, essential fats, and Rejuvenate! superfoods.

HPDI FOUNDATIONAL SUPPLEMENTS

We recommend six basic types of foundational supplements. The six categories are: 1) multivitamin formulas, 2) vitamin C / antioxidant formulas, 3) essential fats, 4) high-RNA foods (Rejuvenate! superfoods), 5) gut health formulas, and 6) hydrogen formulas.

We further break down the six foundational supplements into “primary” and “secondary” foundational supplements. The first four (listed above) being primary and the last two (gut health and hydrogen formulas) being secondary. This doesn’t mean that gut health or hydrogen formulas are less essential, depending on the person. But typically we recommend the first four in order.

We established the original three types of foundational supplements about 1988. We have always recommended multivitamins, vitamin C and antioxidants, and essential fats, as being the most important nutritional supplements for establishing and maintaining general health.

We later added high-RNA foods (like Rejuvenate! superfoods) as a fourth type of foundational supplement because research indicates dietary nucleic acids are essential nutrients—see our many articles on dietary nucleic acids, Dr. Benjamin S. Frank, and about Rejuvenate! superfoods (Original Greens, PLUS, and Berries & Herbs).

Two categories of foundational supplements were added more recently: gut health formulas (especially Restore) and hydrogen formulas. Hank wrote an article (Amending the HPDI Foundational Program) about these changes in April 2016. We added these two categories after much consideration regarding their benefits, and have written extensively about them (see Resources below).

The entire HPDI supplement system is depicted (above) as a cone. The six types of foundational supplements form the base of the cone. Enhancement Formulas and Specific-Condition formulas sit above toward the apex.

ultimate protector foundational supplements

Ultimate Protector Nrf2 formula is a foundational supplement in the vitamin C / antioxidant category.

FOUNDATIONAL SUPPLEMENTS: BEST PRACTICES

I recommend using all six types of HPDI foundational supplements. I personally take the following supplements (below) and present them here as an example of how they can be integrated into a complete supplement regimen. Foundational Supplements I take:

1. Multivitamin: Hank & Brian’s Mighty Multi-Vite! (4 per day in divided doses)

2. Vitamin C / antioxidants: PRO-C (6–8 per day) and Ultimate Protector Nrf2 activator (8–12 per day)

3. Essential Fats: Essential Fats Plus E (4 per day)

4. Rejuvenate!™ superfood: All three Rejuvenate! superfoods (2–8 scoops per day)

5. Gut Health: RESTORE For Gut Health (1–2 ounces per day) and/or a soil-based probiotic (1–3 per week)

6. Hydrogen: Megahydrate (2–6 per day) and/or VR Tablets

Taking one supplement from each of the six foundational supplement categories helps build, support, and maintain optimal health.

We at HPDI recommend everyone take one of each type of foundational supplement. That is, we suggest an individual select for personal use a multivitamin, vitamin C/antioxidant formula, essential fats formula, Rejuvenate!™ superfood (or other high-RNA superfood), hydrogen product, and at least one gut health product (typically RESTORE) depending on their gut-health needs).

Likewise, we suggest health care professionals recommend for their clients one of each of the six types of foundational supplements.

The other two categories in the HPDI nutritional supplement system are Enhancement Formulas and Specific-Condition Formulas (see cone diagram). These are not foundational supplements. However, I include the supplements I take in these categories to show how Enhancement and Specific-Condition Formulas fully integrate with Foundational Supplements to form a complete supplement program providing not only essential nutrients required for health, but also particular nutrients required by me. This makes the system fully “customizable” to individual needs.

Enhancement Formulas I take include: B-Complex-50 (B complex), Myo-Mag (magnesium/malic acid), Ubiquinol-50, Bone Guardian, and Vitamin D3 Plus.

Specific Condition Formulas I take include: Joint Health Formula, Allergy Support Formula, Eye & Vision Formula, Intestinal Rejuvenation Formula, and Warrior Mist (pain topical), and Warrior Sleep (sleep topical).

Thus, I take supplements from all three categories (Foundationals, Enhancements, and Specific-Condition) in the HPDI supplement system. However, I always prioritize foundational supplements—I take them first—because they are the all-important “base” on which my personal supplement program rests.

Foundational supplements ideally are the base on which your supplement program—or those of your clients—rests, as well.

We have seen the results of taking a complete set of foundational supplements. They work because the nutrients they provide are needed by everyone.

foundational supplements multivitamin

Muti Two Caps is a high-potency multivitamin with advanced forms for optimal utilization in the body.

SYNERGY OF FOUNDATIONAL SUPPLEMENTS

Individuals who use all six types of foundational supplements do best in terms of optimizing health. The reason is that all six foundational supplements provide nutrients required for good health.

All six types of foundational supplement provide unique benefits. Yet, each performs functions required by the human body for good health. That is one reason when they are combined they exert synergistic effects for health going far beyond the benefits just using a few types of foundational supplements, depending on individual needs, of course.

A SYSTEM OF FOUNDATIONAL SUPPLEMENTS IS NECESSARY

Individuals benefit from a structured system of supplements that can be tailored to their needs. Otherwise basic nutrients may be left out from daily intake.

For example, I know people who may or may not take a multivitamin. And they may or may not take vitamin C. Yet, they may take calcium for their bones, glucosamine for their joints, and lutein for their eyes. Or they may take a low-potency multivitamin providing merely the RDA for all nutrients.

It is fine that individuals take supplements they regard as important or useful. But that does not guarantee that a wide range—and sufficient levels—of nutrients necessary for health are available to the body on a regular basis.

In fact, I regard the supplement intake programs of most persons to be “hit-or-miss.” They may consume nutrients important for a few functions in the body, yet fail to obtain other essential nutrients required for the nutrients they take to work most effectively. We have written extensively on this topic on our website and in blog articles (see below).

Not taking regularly a complete set of foundational supplements likely means key nutrients (and key levels of nutrients) go missing. Over time, this means fewer and lower levels of nutrients available to support the body’s needs for them at levels known to sustain the good health.

The best way to ensure a sufficient range of nutrients at plentiful levels is to take foundational supplements. After a baseline of nutrients is established by taking foundational supplements, additional supplements can be added, as necessary. Following such a system and using it to customize a personal supplement regimen means there is a far better opportunity to obtain essential nutrients on a daily basis. And not to miss nutrients that help create optimal health.

rejuvenate superfood foundational supplements

High-RNA foods like Rejuvenate! PLUS superfood provide dietary nucleic acids important for health.

A COMPLETE SUPPLEMENT SYSTEM INCLUDES FOUNDATIONAL SUPPLEMENTS

After obtaining sufficient levels of basic nutrients required for health, then a person can add (or you can recommend) specific nutrients or formulas that target certain problems or issues. This is the basis for HPDI’s creation of Enhancement Formulas and Specific-Condition Formulas.

Nutritional supplements in the categories of Enhancement Formulas and Specific-Condition Formulas “stack” on top of HPDI’s Foundational Supplements (see cone diagram above). In this way, a complete nutritional supplement program begins with the most essential nutrients and continues with customizations based on the unique needs of an individual.

ENHANCEMENT FORMULAS

Enhancement Formulas in the HPDI system are supplements we regard as falling into the next tier in terms of importance, at least for most people. They do not necessarily provide essential nutrients, and yet many people (including myself) benefit significantly from them.

Enhancement Formulas include: magnesium formulas (topical and capsule), Vitamin D3 Plus, Nascent Iodine, Vitamin B12 (methylcobalamin), mushroom-based products (like Immune-Assist™), Prolyt (proteolytic enzymes), Digase (plant-based enzymes), and Warrior Mist (topical pain reliever), and many other formulas.

SPECIFIC-CONDITION FORMULAS

In the HPDI system, individuals can add (in a modular way) various formulas and single nutrients designed to support a particular set of needs or a target a specific condition.

We offer a complete range of supplements (almost 100) including a range of supplements formulated to address specific conditions. These include Joint Health Formula, Eye & Vision Formula, Blood Sugar Support, Allergy Support, Prosta Plus, Intestinal Rejuvenation Formula, and many other formulas.

ONE SYSTEM. THREE TIERS. HPDI NUTRITIONAL SUPPLEMENTS.

HPDI Foundational Supplements collectively form the base tier of a complete nutritional supplement system comprised of three tiers: 1) Foundational Supplements (six types), 2) Enhancement Formulas (or simply “Enhancements”), and 3) Specific-Condition Formulas.

Foundational Supplements are necessary because they provide nutrients foundational to health. Taking them daily or recommending your clients take them daily can help mean big differences in health, nutrition, and quality of life.

We at HPDI design our nutritional supplements to be the most effective dietary supplements available. HPDI products are known for: 1) Advanced Formulation (including use of superior forms of nutrients), 2) Ultra-High Purity, 3) Avoidance of Harmful Ingredients, and 4) being made with Good Manufacturing Practices (GMP). For more details, please see The HPDI Difference and our Statement on Additives (Excipients).

At least 40 of HPDI’s products are formulated by Dr. Hank Liers. They fall in all categories in HPDI’s supplement system. They can be found under “Dr. Hank Liers original formulas.”

foundational supplement EFA

Essential Fats Plus E provides well-balanced omega-3 and omega-6 fatty acids.

ADDENDUM: THE BODYSYNC GENETIC TEST & ACTION PLAN

In recent years, genetic tests have become available that show gene variations can cause or predispose a person to serious conditions relating to important body functions such a lessened ability to process synthetic B vitamins (like folic acid), higher blood glucose levels, lower immune system function, and bone density problems relating to variants in the vitamin D receptor (VDR) gene, for example.

We recommend a genetic test to determine whether individuals have certain gene variations impacting health. HPDI has teamed with a genetic testing company (BodySync, Inc.) and sells BodySync test kits on our Reseller site. To read about the BodySync genetic test and test kits click here. Genes tested for in the Bodysync test include variations in genes impacting folate assimilation, cardiovascular health, detoxification, bone health, and more. Resellers can purchase the test kits directly from HPDI and retail customers can call us (800-228-4265) to find out how we can help them get a test kit and support them with any associated counseling regarding the results.

Genetic testing allows individuals to gain a clearer picture of where they may require additional or specific nutritional supplementation. In this respect, HPDI foundational supplements can play a significant role in providing the amounts and range of important nutrients that can help mitigate the adverse effects of certain gene variations in addition to diet, exercise, and lifestyle factors. After testing, you will receive a Bodysync Action Plan that makes recommendations for a healthy diet and lifestyle customized to your unique genetic profile.

FOUNDATIONAL SUPPLEMENTS: FREQUENTLY ASKED QUESTIONS (FAQ)

We frequently get questions from HPDI clients and resellers regarding foundational supplements. These questions include:

“Why did you add gut health and hydrogen products to your foundational supplements program?”
We found it necessary to add categories for gut health and hydrogen because they provide nutrients that are support the body and help ensure the foundational supplement system supports health most effectively. You can read more in previous blog articles (see below).

“Which is the better multivitamin: Multi Two or Mighty Multi-Vite!™?”
It depends on whether you need more B vitamins or antioxidants. Multi Two provides more B vitamins and Mighty Multi-Vite™ provides more antioxidants and cofactors. I take a separate HPDI B-Complex-50 formula, so I take Mighty Multi-Vite!™ as my primary multivitamin.

“What are the differences between Rejuvenate!™ Original, PLUS, and Berries & Herbs superfoods?”
They each provide about 340 mg of dietary nucleic acids. Original is the “greenest” with a large percentage of dietary nucleic acids coming from chlorella and spirunlina. PLUS is our most popular and 30% is identical to Original with more protein and a built-in multivitamin complex. Berries & Herbs contains no greens, yet more nucleic acids (390 mg), protein, and a built-in multivitamin. See our Rejuvenate! comparison page for more information.

“Should I take a vitamin C formula with antioxidants like PRO-C or one with Nrf2 activators like Ultimate Protector?”
Both provide vitamin C and Nrf2 activators, but Ultimate Protector provides more types of Nrf2 activators. Ultimate Protector capsules are smaller than PRO-C capsules, so a daily dose may require taking more capsules.

“How important are hydrogen supplements?”
Very important for energy production, recovery, antioxidant functions, and gut health. Hydrogen supplements like VR Tablets and Megahydrate ensure high levels of hydrogen are available in the body.

What are your best products for supporting gut health?
It depends on your needs: cleansing (Intestinal Rejuvenation Formula), probiotic/microbiome support, or tightening tight junctions in the gut (RESTORE)? We offer products for all these purposes. Typically, the first gut health formula we recommend is RESTORE because so many people require extra support for microbiome health and to restore gut integrity.

These are just a few questions frequently asked about HPDI foundational supplements. If you need more information about products, please contact the HPDI office (800-228-4265) or email support@healthproductsdistributors.com.

You can also contact Fred Liers, PhD or Hank Liers, PhD (formulator) with questions you may have regarding specific products, single nutrients, or formulation.

SOURCES AND RESOURCES

Foundational Supplements

HPDI Full Product Overview

The Need for Foundational Supplements (.pdf)

The HPDI Difference (4 Pillars of Formulation)

HPDI BLOG ARTICLES

Amending the HPDI Foundational Supplements Program

Foundational Supplements Remain Fundamental

Vitamin C / Antioxidants

PRO-C and Ultimate Protector Comparison

Questions and Answers about Ultimate Protector

The Amazing Healing Potential of Natural Nrf2 Activators

Ultimate Protector™: First Impressions

Ultimate Protector™ Brunswick Labs ORAC5.0™ Test Results

Preventing Free-Radical Damage Using Ultimate Protector™

Description and Comparison of ORAC Tests for Well Known Plant Ingredients and Ultimate Protector™

Ultimate Protector and the Role of Foundational Supplements for Health

Natural Phytochemical Nrf2 Activators for Chemoprevention

New Directions for Preventing Free Radical Damage

Review of Scientific Research on Oligomeric Proanthocyanidins (OPC)” by Dr. Hank Liers

“Vitamin C – An Amazing Nutrient” by Dr. Hank Liers

High-RNA Superfoods

Rejuvenate! Berries & Herbs: Ingredients for Optimal Nutrition

“9 Things to Know About Rejuvenate!™ Superfoods”

“High-RNA Rejuvenate!™ Superfood”

“Natural Phytochemical NRF2 Activators for Chemoprevention”

Review of Scientific Research on Oligomeric Proanthocyanidins (OPC)

DIETARY NUCLEIC ACIDS – DR. BENJAMIN S. FRANK, PART 1

DIETARY NUCLEIC ACIDS – DR. BENJAMIN S. FRANK, PART 2

Super-Tasty Morning Nutritional Drinks

Hydrogen

The Science Behind Megahydrate

Hydrogen for Optimal Health

Wonders of Molecular Hydrogen

Gut Health

Gut Health – Effects of Glyphosate and Antibiotics

Gut Health – Intestinal Rejuvenation Formula

PRODUCTS

Vitamin formulas, including multivitamins

Rejuvenate!™ Berries & Herbs

Rejuvenate!™ PLUS

Rejuvenate!™ (Original)

Rejuvenate! Superfoods: Product Comparison

Ultimate Protector™ Nrf2 Activator (vitamin C/antioxidant)

PRO-C™ (Vitamin C/Antioxidant formula)

Essential Fats Plus E

Intestinal Rejuvenation Formula (gut health)

Restore For Gut Health (lignite formula)

Active H2 (hydrogen)

Megahydrate (hydrogen)

VR Tablets (hydrogen)

Prescript-Assist™ (probiotic/prebiotic)

HPDI FOUNDATIONAL SUPPLEMENTS