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PRO-C ANTIOXIDANT FORMULA UPDATE + VIDEO

Dr. Hank Liers, PhD pro-c™ pro-c super antioxidant formulaFred Liers PhD pro-c antioxidant vitamin c nrf2 formulaLooking for an advanced antioxidant formula? Already using or recommending vitamin C? Curious about cellular Nrf2 activation? Look no further than PRO-C™.

PRO-C™ is among the most effective antioxidant formulas available. It is an HPDI foundational supplement that works most effectively when used with multivitamins, essential fats, and superfoods. However, it is also an excellent standalone formula that can rapidly provide the body with extremely high protection from free radicals.

We ourselves have taken PRO-C daily for many years with excellent results. Our personal experience together with detailed feedback from health professionals and end-users affirms the effectiveness of PRO-C as a super-antioxidant–vitamin C-Nrf2 activator formula.

PRO-C provides 500 mg of buffered vitamin C per capsule (buffered with calcium, magnesium, and zinc) along with grape extract (seed, skin, pulp) and green tea extract (95% polyphenols). In addition, we include a special combination of the “network antioxidants” l-glutathione (reduced), n-acetyl-l-cysteine (NAC), r-lipoic acid, and selenium. Vitamin B2 and Vitamin B6 in coenzyme forms support the enzymatic effectiveness of the “network antioxidants”. The formula works so well because this combination of ingredients leverages the antioxidant power of vitamin C, grape extract, green tea extract, and the other nutrients to act synergistically in order to maximize effectiveness.

FORMULATION HISTORY AND THE SCIENCE BEHIND PRO-C™

What you may not know is the history of the development PRO-C and the scientific knowledge on which Dr. Hank Liers based his formulation of it.

Dr. Hank formulated his first product in 1989. It was a potent antioxidant formula he called PYC-C™ (sounds like “pixie”). PYC-C consisted of a combination of buffered Vitamin C (including magnesium, calcium, and zinc ascorbates) and pycnogenols from pine bark.

Much of the scientific research data Dr. Hank collected during the development of PYC-C regarding oligomeric proanthocyanidins (OPC) he later incorporated into an article (currently published on this blog) titled “Review of Scientific Research on Oligomeric Proanthocyanidins (OPC)” (rev. 2017)

By 1997 Dr. Hank had gathered a great deal of new scientific information regarding green tea catechins and the nutrients termed “network antioxidants” by Dr. Lester Packer, director of Packer Lab at University of California, Berkeley. Beyond this information, Dr. Hank studied additional research regarding how various nutrients worked together synergistically. At that point, he was ready to formulate the new, improved PRO-C™ super antioxidant formula.

PRO-C combines the ingredients of PYC-C (now known as OPC-C™) and uses grape pulp, skin, and seed extract with green tea extract (with high polyphenols >95% and EpiGalloCatechinGalate (EGCG) >45%), n-acetyl-l-cysteine (NAC), reduced glutathione (GSH), R-lipoic acid, selenium, and coenzyme Vitamins B2 and B6.

PRO-C super antioxidant formula 180 cap 90 cap

HPDI launched PRO-C™ in late 1997. It rapidly became one of our best-selling products. Our customers raved about how effective it was for them if they felt like they were “coming down with something” (like a cold, flu, virus, infection, etc.). Greater skin elasticity greatly helped pregnant women avoid stretch marks and episiotomies. Today, we highly recommend its use together with our other Foundational Supplements to ensure optimal health and anti-aging effects.

THE PRO-C™ SUPER ANTIOXIDANT FORMULA

PRO-C™ super antioxidant formula is extremely synergistic, especially in so far as it increases the body’s ability to quench free radicals in its aqueous (i.e., water-based) compartments. Because antioxidants may become free radicals themselves after they have done their job, the body has developed an elaborate system for recovery of oxidized antioxidants.

 

Dr. Lester Packer was the primary researcher investigating the synergistic character of antioxidants. He made this statement in his interview with Dr. Richard Passwater after publication of Packer’s The Antioxidant Miracle (1999):

[The major theme of] The Antioxidant Miracle is that antioxidants work in a coordinated manner. They interact with one another, and this interaction, which we like to call the antioxidant network, is very important to the overall antioxidant defense that we possess. The key members of the antioxidant network are vitamin E and vitamin C, but there are other participants in this network. These are thiol antioxidants, antioxidants that contain sulfur groups in the body. Glutathione perhaps is the best known of these, but there are other sulfur-containing antioxidants that also are very important.”

Dr. Packer continues:

“This whole antioxidant network works like an orchestra depending on individuals who have, of course, different complements of antioxidants depending upon their nutritional regimens and the individuality of their own body metabolisms. The idea behind having a network of antioxidants is that if one antioxidant happens to be deficient the others can compensate and still keep the antioxidant defense system strong.”

The following diagram shows some of the relationships in the antioxidant network and how they support each other.

Lester Packer antioxidant network diagram Figure 1 – Dr. Packer’s Antioxidant Network

We see, for example, reduced glutathione (GSH) has the ability to reduce oxidized Vitamin C back to its unoxidized state. Vitamin C reduces oxidized Vitamin E back to its unoxidized state, and both reduces glutathione and spares it for other important functions, including detoxification and immune enhancement.

Many polyphenols (e.g., oligomeric proanthocyanidins (OPCs), anthocyanidins and catechins) found in red grape and green tea extracts spare Vitamin C and glutathione in the body, as well as operate as powerful antioxidants, anti-inflammatories, and connective tissue strengtheners.

grapes grape extract antioxidant

Grapes provide antioxidant nutrients such as polyphenols, OPCs, anthocyans, and resveratrol.

R-Lipoic Acid (see abstracts below) operates as an antioxidant both in its oxidized and reduced states, reduces the oxidized forms of both Vitamin E and Vitamin C, and and has been shown to enhance glutathione levels. Because several of these substances are able to protect Vitamin E contained in cell membranes, this combination also has a significant beneficial effect on the fat soluble antioxidant status of the body!

The nutrients in PRO-C have been carefully selected and balanced to provide optimal effects, especially as related to free radical protection, detoxification, immune system enhancement, connective tissue strengthening, and reduction of inflammation. PRO-C therefore provides outstanding nutritional support in a wide variety of conditions of poor health, as well as acts to support and maintain a state of health and well-being.

It the last several years the research results on Nrf2 activators have become well known and products developed that take advantage of these nutrients. For details see our blog article Natural Phytochemical Nrf2 Activators for Chemoprevention. Researchers have been studying specifically how enzyme-activating substances such as OPCs and anthocyans activate a transcription factor known as Nrf2 that causes the body to endogenously produce higher levels of a wide variety of protective enzymes including superoxide dismutase (SOD), catalase, and glutathione peroxidase.

Although we did not know about Nrf2 activators in 1997 when we formulated PRO-C, we have subsequently learned that four of the ingredients in the formula have powerful Nrf2 activity. These include grape seed extract, green tea extract, NAC, and r-lipoic acid. With this knowledge, we now understand that PRO-C provides both powerful external antioxidants (with extremely high ORAC5.0 values) that support redox cycles within the body, but also provides ingredients that allow the body to endogenously produce powerful protective enzymes for even greater free-radical protection and health.

PRO-C™ ANTIOXIDANT FORMULA INGREDIENTS

PRO-C contains buffered vitamin C (in the form of powdered calcium, magnesium, and zinc ascorbates), high-potency grape extract (from grape pulp, skins, and seeds), green tea extract (with>95% polyphenols and >45% EGCG), reduced glutathione, N-Acetyl-L-Cysteine (NAC), R-lipoic acid, coenzyme forms of vitamin B2 (R5P) and vitamin B6 (P5P), and selenium.

Below we will discuss each ingredient and show some of the research that confirms its effectiveness.

VITAMIN C

Vitamin C typically is called l-ascorbic acid or ascorbate and is an essential nutrient for humans and other animal species. The term “vitamin C” refers to a number of vitamins that have vitamin C activity in animals, including ascorbic acid and its salts (e.g., magnesium ascorbate, calcium ascorbate, sodium ascorbate, etc.), and some oxidized forms such as dehydroascorbate and semidehydroascorbate.

Vitamin C is known to perform many critical functions within the body involving detoxification, tissue building, immune enhancement, pain control, and controlling or killing pathogenic organisms. It is also known to be helpful for wound and bone healing, healthy skin and eyes, fighting infections, stress control, toxic exposure, and repairing damaged tissue of all types. For much more information on the many benefits of Vitamin C see our blog article Vitamin C – An Amazing Nutrient.

Below are two abstracts that show some of the beneficial effects of Vitamin C when used with other network antioxidants:

ABSTRACT 1:
Exhaustive physical exercise causes oxidation of glutathione status in blood: prevention by antioxidant administration.
Sastre J, Asensi M, Gasco E, Pallardo FV, Ferrero JA, Furukawa T, Vina J
In: Am J Physiol (1992 Nov) 263(5 Pt 2):R992-5

We have studied the effect of exhaustive concentric physical exercise on glutathione redox status and the possible relationship between blood glutathione oxidation and blood lactate and pyruvate levels. Levels of oxidized glutathione (GSSG) in blood increase after exhaustive concentric physical exercise in trained humans. GSSG levels were 72% higher immediately after exercise than at rest. They returned to normal values 1 h after exercise. Blood reduced glutathione (GSH) levels did not change significantly after the exercise. We have found a linear relationship between GSSG-to-GSH and lactate-to-pyruvate ratios in human blood before, during, and after exhaustive exercise. In rats, physical exercise also caused an increase in blood GSSG levels that were 200% higher after physical exercise than at rest. GSH levels did not change significantly. Thus, both in rats and humans, exhaustive physical exercise causes a change in glutathione redox status in blood. We have also found that antioxidant administration, i.e., oral vitamin C, N-acetyl-L- cysteine, or glutathione, is effective in preventing oxidation of the blood glutathione pool after physical exercise in rats.

ABSTRACT 2:
The effect of glutathione and vitamins A, C, and E on acute skin flap survival.

Hayden RE, Paniello RC, Yeung CS, Bello SL, Dawson SM
In: Laryngoscope (1987 Oct) 97(10):1176-9

Vitamins A, C, and E act as antioxidants and as free radical scavengers in biological systems. Glutathione is involved in several reactions in vitamin metabolism and also plays an important role in cell membrane protection against lipid peroxidation by free radicals. We sought to use these natural defense mechanisms against oxygen free radicals formed during reperfusion of ischemic skin flaps. An acute axial random skin flap model was utilized in the rat. Vitamins or glutathione were administered by oral gastric tube or intravenously in the perioperative period, and survival of the flap was measured at 1 week. Glutathione, beta-carotene, ascorbic acid and alpha-D- tocopherol showed mean flap survival of 84% to 89%, each of which was significantly improved over saline controls (67% p less than .0005). The mechanisms and biochemistry of these vitamins, and their interactions with other vitamins and with glutathione, are discussed, along with clinical implications of free radical scavenging and skin flap survival.

GRAPE EXTRACT

Grape extract (seeds, skin, pulp) contain highly bioavailable bioflavonoid complexes that in research studies have been shown to have powerful antioxidant capability. The Oligomeric Proanthocyanidins (OPCs) in grape seed extract are able to strengthen collagen fibers in aging or damaged connective tissue and can act as a preventative against connective tissue degradation.

Some research indicates that anthocyans, which are found in extracts of grape skin and stems (but not in grape seed extract), can reduce oxidized glutathione while at the same time become reduced themselves. In addition, extracts of grape skin and stems (but not those of grape seed extract) contain a material called trans-resveratrol that has been shown to have chemopreventive effects.

Below we have provided some of the abstracts that are included in our broad list of relevant abstracts for PRO-C.

ABSTRACT 3:
Protective effects of grape seed proanthocyanidins and selected antioxidants against TPA-induced hepatic and brain lipid peroxidation and DNA fragmentation, and peritoneal macrophage activation in mice.
Bagchi D, Garg A, Krohn RL, Bagchi M, Bagchi DJ, Balmoori J, Stohs SJ
In: Gen Pharmacol (1998 May) 30(5):771-6

1. The comparative protective abilities of a grape seed proanthocyanidin extract (GSPE) (25-100 mg/kg), vitamin C (100 mg/kg), vitamin E succinate (VES) (100 mg/kg) and beta-carotene (50 mg/kg) on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced lipid peroxidation and DNA fragmentation in the hepatic and brain tissues, as well as production of reactive oxygen species by peritoneal macrophages, were assessed. 2. Treatment of mice with GSPE (100 mg/kg), vitamin C, VES and beta-carotene decreased TPA-induced production of reactive oxygen species, as evidenced by decreases in the chemiluminescence response in peritoneal macrophages by approximately 70%, 18%, 47% and 16%, respectively, and cytochrome c reduction by approximately 65%, 15%, 37% and 19%, respectively, compared with controls. 3. GSPE, vitamin C, VES and beta-carotene decreased TPA-induced DNA fragmentation by approximately 47%, 10%, 30% and 11%, respectively, in the hepatic tissues, and 50%, 14%, 31% and 11%, respectively, in the brain tissues, at the doses that were used. Similar results were observed with respect to lipid peroxidation in hepatic mitochondria and microsomes and in brain homogenates. 4. GSPE exhibited a dose-dependent inhibition of TPA- induced lipid peroxidation and DNA fragmentation in liver and brain, as well as a dose-dependent inhibition of TPA-induced reactive oxygen species production in peritoneal macrophages. 5. GSPE and other antioxidants provided significant protection against TPA-induced oxidative damage, with GSPE providing better protection than did other antioxidants at the doses that were employed.

ABSTRACT 4:
Clinical and capillaroscopic evaluation of chronic uncomplicated venous insufficiency with procyanidins extracted from vitis vinifera
Costantini A, De Bernardi T, Gotti A
In: Minerva Cardioangiol (1999 Jan-Feb) 47(1-2):39-46

BACKGROUND: The pharmacological treatment of non-complicated chronic venous insufficiency is a current and well-debated topic. The introduction of new products with action on the venous system, improved knowledge on the physiopathology of venous insufficiency and the possibility provided by new analytical instruments, have given new impulse to the consolidation of the clinical value of phlebotonics in this indication. METHODS: In light of this, 24 patients with non-complicated chronic venous insufficiency were treated with oral administration of Oligomeric Proanthocyanidins (Pycnogenols-OPC) 100 mg/day. To evaluate the therapeutic efficacy of the treatment, an instrumental evaluation by optical probe capillaroscope was employed in addition to the traditional subjective clinical parameters: swelling, itching, heaviness and pain. The videocapillaroscope examination was performed at the lower third of the leg and the first toe. Edema in the capillaroscopic field, the number of observable capillaries and the capillary dilatation were the parameter chosen to evaluate the efficacy of treatment. All patients completed the study with no reports of adverse events during the period of observation. RESULTS: The results obtained show a positive clinical response (improved or absent symptoms) in over 80% of patients, with significant improvement of symptoms already evident after the first 10 days of treatment. The mechanism of action of the OPCs explains the rapid reduction of the swelling of the lower limbs and correlated with this are the other evaluable symptoms: heaviness and itching. Particularly striking results were observed for itching and pain which completely disappeared during the course of therapy in 80% and 53% of the patients respectively. Noteworthy is the good correlation between the clinical and instrumental data, with improvement in a total of 70% of patients. CONCLUSIONS: The results obtained in the course of this clinical experience, with evident improvement already during the first weeks of treatment, the absence of adverse events added to the benefit of a once-a-day administration, justify the use of OPC in the treatment of non-complicated chronic venous insufficiency.

ABSTRACT 5:
Polymeric procyanidin fraction from defatted grape seeds protects HepG2 cells against oxidative stress by inducing phase II enzymes via Nrf2 activation.
Younghwa Kim, Youngmin Choi, Hyeonmi Ham, Heon-Sang Jeong, Junsoo Lee
Kim, Y., Choi, Y., Ham, H. et al. Food Sci Biotechnol (2013) 22: 485. https://doi.org/10.1007/s10068-013-0105-x

Nuclear factor erythroid 2-related factor 2 (Nrf2) is an important transcription factor that regulates antioxidant response element (ARE)-driven phase II detoxification enzymes. In this study, induction of phase II enzymes via Nrf2/ARE activation in the cytoprotective effect of crude polyphenol extract (CPE), oligomeric procyanidin fraction (OPF), and polymeric procyanidin fraction (PPF) from defatted grape seeds in HepG2 cells was evaluated. Among these treatments, the treatment with PPF significantly increased Nrf2 protein expression in the nuclear fraction. Treating the samples increased heme oxygenase-1 (HO-1) and NAD(P)H:quinone oxidoreductase 1 (NQO1) protein expression in a dose-dependent manner, and PPF significantly increased the levels of phase II enzymes. Cellular generation of reactive oxygen species (ROS) were effectively reduced by PPF. These results suggest that pretreatment with PPF shows a cytoprotective effect by inhibiting ROS production and inducing HO-1 and NQO1 expression via Nrf2 activation in HepG2 cells.

GREEN TEA EXTRACT

Green tea extract is obtained from the unfermented leaves of Camellia sinensis for which numerous biological activities have been reported including: antimutagenic, antibacterial, hypocholesterolemic, antioxidant, and protective against tumorigenesis. Below we have selected a few of the many abstracts we have on file showing the benefit of green tea extract.

Green tea antioxidant polyphenols catechins

Green tea leaves are high in antioxidant polyphenols and catechins.

ABSTRACT 6:
Enhancement of antioxidant and phase II enzymes by oral feeding of green tea polyphenols in drinking water to SKH-1 hairless mice: possible role in cancer chemoprevention.
Khan SG, Katiyar SK, Agarwal R, Mukhtar H
In: Cancer Res (1992 Jul 15) 52(14):4050-2

Following the oral feeding of a polyphenolic fraction isolated from green tea (GTP) in drinking water, an increase in the activities of antioxidant and phase II enzymes in skin, small bowel, liver, and lung of female SKH-1 hairless mice was observed. GTP feeding (0.2%, w/v) to mice for 30 days significantly increased the activities of glutathione peroxidase, catalase, and quinone reductase in small bowel, liver, and lungs, and glutathione S-transferase in small bowel and liver. GTP feeding to mice also resulted in considerable enhancement of glutathione reductase activity in liver. In general, the increase in antioxidant and phase II enzyme activities was more pronounced in lung and small bowel as compared to liver and skin. The significance of these results can be implicated in relation to the cancer chemopreventive effects of GTP against the induction of tumors in various target organs.

ABSTRACT 7:
INHIBITORY EFFECT OF SIX GREEN TEA CATECHINS AND CAFFEINE ON THE GROWTH OF FOUR SELECTED HUMAN TUMOR CELL LINES.
In: Anticancer Drugs (1996 Jun) 7(4):461-8
Institutional address: Department of Pharmacology and Toxicology College of Pharmacy University of Arizona Tucson 85721 USA.

Green tea is an aqueous infusion of dried unfermented leaves of Camellia sinensis (family Theaceae) from which numerous biological activities have been reported including antimutagenic, antibacterial, hypocholesterolemic, antioxidant, antitumor and cancer preventive activities. From the aqueous-alcoholic extract of green tea leaves, six compounds (+)-gallocatechin (GC), (-)-epicatechin (EC), (-)- epigallocatechin (EGC), (-)-epicatechin gallate (ECG), (-)- epigallocatechin gallate (EGCG) and caffeine, were isolated and purified. Together with (+)-catechin, these compounds were tested against each of four human tumor cells lines (MCF-7 breast carcinoma, HT-29 colon carcinoma, A-427 lung carcinoma and UACC-375 melanoma). The three most potent green tea components against all four tumor cell lines were EGCG, GC and EGC. EGCG was the most potent of the seven green tea components against three out of the four cell lines (i.e. MCF-7 breast cancer, HT-29 colon cancer and UACC-375 melanoma). On the basis of these extensive in vitro studies, it would be of considerable interest to evaluate all three of these components in comparative preclinical in vivo animal tumor model systems before final decisions are made concerning which of these potential chemopreventive drugs should be taken into broad clinical trials.

GLUTATHIONE AND N-ACETYL-L-CYSTEINE (NAC)

Glutathione and NAC (a major precursor of glutathione) both provide important protection against toxins and free radicals, and can strengthen the immune system. Glutathione is considered to be one of the most important protective substances in the human body with almost 60% of liver detoxification accounted for by this key substance. In addition, glutathione is one of the most potent anti-viral substances known.

Some research has indicated that glutathione may not be able to enter easily into certain types of cells, but NAC is able to enter these cells and be converted into glutathione once inside the cell. Thus, the combination of glutathione and NAC appear to be more potent than either alone.

Below we provide some of the key abstracts we have on file regarding NAC and glutathione.

ABSTRACT 8
GSH rescue by N-acetylcysteine.
Ruffmann R Wendel A
In: Klin Wochenschr (1991 Nov 15) 69(18):857-62

Reduced glutathione (GSH) is the main intracellular low molecular weight thiol. GSH acts as a nucleophilic scavenger and as an enzyme-catalyzed antioxidant in the event of electrophilic/oxidative tissue injury. Therefore, GSH has a major role as a protector of biological structures and functions. GSH depletion has been recognized as a hazardous condition during paracetamol intoxication. Conversely, GSH rescue, meaning recovery of the protective potential of GSH by early administration of N-acetylcysteine (NAC), has been found to be life-saving. Lack of GSH and electrophilic/oxidative injury have been identified among the causes of the adult respiratory distress syndrome (ARDS), idiopathic pulmonary fibrosis (IPF), and the acquired immunodeficiency syndrome (AIDS). Experimental and early clinical data (in ARDS) point to the role of NAC in the treatment of these conditions. Recently, orally given NAC has been shown to enhance the levels of GSH in the liver, in plasma, and notably in the bronchoalveolar lavage fluid. Rescue of GSH through NAC needs to be appreciated as an independent treatment modality for an array of different disease, all of which have one feature in common: pathogenetically relevant loss of GSH.

ABSTRACT 9
Cysteine and glutathione concentrations in plasma and bronchoalveolar lavage fluid after treatment with N-acetylcysteine.
Bridgeman MM Marsden M MacNee W Flenley DC Ryle AP
In: Thorax (1991 Jan) 46(1):39-42

N-acetylcysteine (600 mg/day) was given to patients by mouth for five days before bronchoscopy and bronchoalveolar lavage to determine whether N-acetylcysteine could increase the concentrations of the antioxidant reduced glutathione in plasma and bronchoalveolar lavage fluid. Bronchoalveolar lavage was performed 1-3 hours (group 2, n = 9) and 16-20 hours (group 3, n = 10) after the last dose of N-acetylcysteine and the values were compared with those in a control group receiving no N-acetylcysteine (group 1, n = 8). N-Acetylcysteine was not detected in plasma or lavage fluid. Plasma concentrations of cysteine, the main metabolite of N-acetylcysteine and a precursor of reduced glutathione, were greater in the groups receiving treatment (groups 2 and 3) than in group 1. Cysteine concentrations in lavage fluid were similar in the three groups. Concentrations of reduced glutathione were greater in both plasma and lavage fluid in group 2 than in group 1. These data suggest that N-acetylcysteine given by mouth is rapidly deacetylated to cysteine, with resulting increases in the concentrations of cysteine in plasma and of reduced glutathione in plasma and the airways, which thus temporarily increase the antioxidant capacity of the lung.

R-LIPOIC ACID / ALPHA-LIPOIC ACID

R-Lipoic Acid is normally made at low levels in the human body, where it functions primarily as an important metabolic nutrient in the conversion of pyruvic acid into acetyl coenzyme A. As such, it plays a crucial role in the metabolism of both fats and carbohydrates into energy. In addition, r-lipoic acid functions as an extremely powerful antioxidant capable of trapping many different types of free radicals in the body.

Because it is both water and fat soluble, lipoic acid is able to operate in a broader range of body tissues than most other antioxidants. Its small size allows lipoic acid to enter areas of the body not easily accessible to many other substances; this allows lipoic acid, for example, to enter the cell nucleus and prevent free-radical damage to DNA.

Because it is such a powerful antioxidant and can easily function as such in both a reduced and oxidized state, lipoic acid is able to protect other important antioxidants such as glutathione, Vitamin E, and Vitamin C. R-lipoic acid is also able to chelate heavy metals such as lead, cadmium, mercury, free iron, and free copper out of the body.

Below we provide relevant scientific abstracts from our database regarding R-Lipoic acid.

ABSTRACT 10:
Alpha-Lipoic acid as a biological antioxidant.
Packer L Witt EH Tritschler HJ
In: Free Radic Biol Med (1995 Aug) 19(2):227-50

alpha-Lipoic acid, which plays an essential role in mitochondrial dehydrogenase reactions, has recently gained considerable attention as an antioxidant. Lipoate, or its reduced form, dihydrolipoate, reacts with reactive oxygen species such as superoxide radicals, hydroxyl radicals, hypochlorous acid, peroxyl radicals, and singlet oxygen. It also protects membranes by interacting with vitamin C and glutathione, which may in turn recycle vitamin E. In addition to its antioxidant activities, dihydrolipoate may exert prooxidant actions through reduction of iron. alpha-Lipoic acid administration has been shown to be beneficial in a number of oxidative stress models such as ischemia-reperfusion injury, diabetes (both alpha-lipoic acid and dihydrolipoic acid exhibit hydrophobic binding to proteins such as albumin, which can prevent glycation reactions), cataract formation, HIV activation, neurodegeneration, and radiation injury. Furthermore, lipoate can function as a redox regulator of proteins such as myoglobin, prolactin, thioredoxin and NF-kappa B transcription factor. We review the properties of lipoate in terms of (1) reactions with reactive oxygen species; (2) interactions with other antioxidants; (3) beneficial effects in oxidative stress models or clinical conditions.

ABSTRACT 11:
Regeneration of glutathione by α-lipoic acid via Nrf2/ARE signaling pathway alleviates cadmium-induced HepG2 cell toxicity.
Zhang J, Zhou X, Wu W, Wang J, Xie H, Wu Z.
In: Environ Toxicol Pharmacol. 2017 Apr;51:30-37. doi: 10.1016/j.etap.2017.02.022. Epub 2017 Feb 27.

Alpha-lipoic acid (α-LA) is an important antioxidant that is capable of regenerating other antioxidants, such as glutathione (GSH). However, the underlying molecular mechanism by which α-LA regenerates GSH remains poorly understood. The current study aimed to investigate whether α-LA regenerates GSH by activation of Nrf2 to alleviate cadmium-induced cytotoxicity in HepG2 cells. In the present study, we found that cadmium induced cell death by depletion of GSH through inactivation of Nrf2. Addition of α-LA to cadmium-treated cells reactivated Nrf2 and regenerated GSH through elevating the Nrf2-downstream genes γ-glutamate-cysteine ligase (γ-GCL) and GR, both of which are key enzymes for GSH synthesis. However, blocking Nrf2 with brusatol in the cells co-treated with α-LA and cadmium reduced the mRNA and the protein levels of γ-GCL and GR, thus suppressed GSH regeneration by α-LA. Our results indicated that α-LA activated Nrf2 signaling pathway, which upregulated the transcription of the enzymes for GSH synthesis and therefore GSH contents to alleviate cadmium-induced cytotoxicity in HepG2 cells.

SELENIUM

Selenium has been shown by clinical research to be a key mineral in the body’s defenses against free radicals and has been shown to be a major factor in reducing the symptoms of HIV infections and in the prevention of tumors. Selenium is used in conjunction with glutathione to form the powerful enzyme glutathione peroxidase that is responsible for detoxification of peroxides formed during the process of aerobic metabolism in humans and other animals.

ABSTRACT 12
Serum selenium concentrations in rheumatoid arthritis.
In: Ann Rheum Dis (1991 Jun) 50(6):376-8

O’Dell JR, Lemley-Gillespie S, Palmer WR, Weaver AL, Moore GF, Klassen LW

Selenium is a trace element and an essential part of the enzyme glutathione peroxidase, which protects cells from oxidative damage. Selenium has been shown to have antiproliferative, anti-inflammatory, antiviral, and immune altering effects. Serum selenium concentrations in 101 patients with seropositive rheumatoid arthritis were found to be significantly lower than those in 29 normal, healthy controls (mean (SD) 148 (42) v 160 (25) micrograms/l) and also lower than those in eight patients with fibrositis (148 (42) v 166 (25) micrograms/l). It is speculated that serum selenium concentrations may modulate the effect of viral or other infections in subjects with the appropriate genetic background and in this way enhance the development or progression of rheumatoid arthritis.

ABSTRACT 13
Studies on selenium in top athletes.
Dragan I, Ploesteanu E, Cristea E, Mohora M, Dinu V, Troescu VS
In: Physiologie (1988 Oct-Dec) 25(4):187-90

The authors performed a controlled trial in 18 top athletes (9 weight lifters and 9 rowers, girls) in order to make evident some chronic and acute effects (antioxidant) of selenium. Nonprotein–SH (essential glutathione), lipid peroxides (MDA-malondialdehyde), glucose-6-phosphate dehydrogenases (G-6-PDH) and fructose-1,6- diphosphate aldolase in serum, have been recorded initially on basal conditions, after 3 weeks of treatment (100 micrograms/day selenium or placebo) and again after 3 weeks of treatment, also on basal conditions, when crossing over the groups (between a free interval of 10 days). In another trial we registered these parameters on basal conditions and after two hours of hard training accompanied by a per oral administration of 150 micrograms selenium (respectively placebo). The results show significant changes under selenium treatment of the peroxides, G-6-PDH and light changes, not significant of the nonprotein–SH, changes which could suggest an antioxidant effect of this element.

VITAMINS B2 and B6 IN COENZYME FORMS

Vitamin B2 as coenzyme riboflavin-5-phosphate is a key vitamin that supports the regeneration of glutathione (via glutathione reductase). Vitamin B6 as coenzyme pyridoxal-5-phosphate is a key vitamin that supports the ability of glutathione to combine with toxic substances (via glutathione transferase) in the process of eliminating them from the body. They are especially effective in their coenzyme forms which allows them to be directly utilized by the body starting in the intestinal tract.

MAGNESIUM, CALCIUM, AND ZINC

Magnesium, zinc, and calcium synergistically work with (and enhance the effects of) the other ingredients in PRO-C. Minerals are especially needed as active components of enzymes that drive metabolic activity. For example, magnesium is required in the functioning of more than 325 types of enzymes.

PRO-C™ SUPER ANTIOXIDANT FORMULA BENEFITS

HIGHLY EFFECTIVE VITAMIN C FORMULA PLUS ANTIOXIDANTS. A complete vitamin C formula, a powerful antioxidant Formula, and Nrf2 activator combined in a single advanced supplement!

POWERFUL, SYNERGISTIC FREE-RADICAL QUENCHING FORMULA. PRO-C™ components work together to quench free radicals in your body. Vitamin C enables grape seed extract to function more effectively, and conversely grape seed extract potentiates vitamin C. Green tea extract boosts ORAC (Oxygen Radical Absorbance Capacity) value.

PROVIDES SIGNIFICANT AMOUNTS OF POWERFUL NRF2 ACTIVATORS (from Grape Extract, Green Tea Extract, NAC, and R-Lipoic Acid) that stimulate the production of the body’s own protective antioxidants including superoxide dismutase, catalase, glutathione peroxidase, and heme oxygenase.

SUPERIOR, BUFFERED (NON-ACIDIC) FORM OF VITAMIN C. Mineral Ascorbates never acidify your body, keeping you pH balanced. Staying alkaline is an important element in maintaining a healthy body.

RAPID ASSIMILATION. Capsule form ensures rapid uptake and assimilation in the body. You may also empty capsule contents into water, food, or directly Into mouth, if desired. Good, mildly tart taste!

COMPOSITION OF PRO-C™ SUPER ANTIOXIDANT FORMULA

One (1) vegetarian capsule of PRO-C provides the following percentages of the Daily Value:

NUTRIENT AMOUNT % Daily Value
Vitamin C (from mineral ascorbates) 500 mg 833%
BioVin® Grape Extract 30 mg *
Green Tea Extract 30 mg *
Calcium (from calcium ascorbate) 23 mg 2.3%
Magnesium (from magnesium ascorbate) 23 mg 5.7%
L-Glutathione (reduced) 20 mg *
N-Acetyl-L-Cysteine (NAC) 15 mg *
R-Lipoic Acid 5 mg *
Zinc (from zinc ascorbate) 2 mg 13%
Vitamin B2 (from riboflavin-5′-phosphate) 1 mg 118%
Vitamin B6 (from pyridoxal-5′-phosphate) 1 mg 50%
Selenium (from l-selenomethionine) 10 mcg *

* No established Daily Value

DIRECTIONS: As a dietary supplement take 1–3 capsules or more daily in divided doses (i.e., spread out over the day), or as recommended by a health care professional. It initially may be useful to take up to 6 capsules per day in divided doses for one week. The contents of the capsule may be emptied into juice or food, as needed.

INGREDIENTS: PRO-C™ SUPER ANTIOXIDANT FORMULA contains only the highest-quality USP grade magnesium ascorbate, USP grade calcium ascorbate, BioVin® grape extract (greater than 75% polyphenols, 55% OPC, greater than 3.5% anthocyanidins from grape pulp, skins, and seeds, and a small amount of trans resveratrol), green tea extract (95% min. polyphenols and 45% min. EGCG), l-glutathione (reduced), USP grade n-acetyl-l-cysteine, USP grade zinc ascorbate, r-(+)-lipoic acid, riboflavin-5′-phosphate, pyridoxal-5′-phosphate, l-selenomethionine, the smallest amounts of microcrystalline cellulose and silica in a vegetarian capsule.

PRO-C™ does not contain wheat, rye, oats, corn antigen, barley, gluten, soy, egg, dairy, yeast, sugar, sulfates, phosphates (other than coenzyme forms), fats, chlorides, GMOs, wax, preservatives, colorings, or artificial flavorings.

Click here to order PRO-C™.

SOURCES & RESOURCES

BOOKS

The Antioxidant Miracle. Lester Packer, PhD, and Carol Coleman. New York: John Wiley and Sons, 1999.

How to Live Longer and Feel Better. Dr. Linus Pauling. Corvallis, OR: Oregon State University Press, 2006.

ARTICLES

Review of Scientific Research on Oligomeric Proanthocyanidins (OPC)” (rev. 2017) by Hank Liers, PhD

“Vitamin C – An Amazing Nutrient” by Hank Liers, PhD

PRO-C™ and Ultimate Protector™ – Comparison by Hank Liers, PhD

“Antioxidant Cocktail Update: Part 1: The Take Home Message is to Use Antioxidant Supplements”
(An interview of Dr. Lester Packer by Richard A. Passwater, PhD, Whole Foods Magazine 1999)

ABSTRACTS

PRO-C™ / Vitamin C Abstracts

Catechin Abstracts

N-Acetyl-L-Cysteine (NAC) Abstracts

Lipoic Acid Abstracts

WEBSITES

Orthomolecular.org
(Therapeutic Nutrition Based Upon Biochemical Individuality)

PRODUCTS

PRO-C™Super Antioxidant Formula

Ultimate Protector™Nrf2 Activator Formula

OPC-C™

HPDI Vitamin C Products

1

NUTRITIONAL APPROACHES SUPPORT THE BODY AGAINST VIRUSES

Dr. Hank Liers, PhD virus nutritional approaches

Fred Liers PhD virus nutritional approaches

“Flu season” is here. It’s hard to escape it—as evidenced by sick friends and coworkers—and maybe yourself or family members. Not to mention exhortations to get flu shots in the media and elsewhere.

Flu indeed dominates health news during the winter. This year it coincides with massive media coverage on the Ebola virus.

Are flu shots worth taking to protect against viral illness? The Centers for Disease Control and Prevention (CDC) admits the flu shot may not be effective this year.

In fact, the flu vaccine may offer offer little protection. There are simply too many influenza strains to cover. This year’s vaccine was in production when CDC realized the vaccine does not include the most virulent strain of the season.

What about protection against other viruses? There are thousands. Yet, there are many things you can do to ensure your body can defend itself.

From a perspective of natural healing, the best—and perhaps only—thing to do to combat viruses is establish good health and strong immunity, and then maintain them.

More specifically, natural nutritional approaches supporting the body against viruses include:

1) Establish solid foundational nutrition and optimal nutrients intake though diet and nutritional supplements

2) Build immunity by natural means, including specific immune-enhancing formulas.

3) Take appropriate natural antimicrobial (e.g., antiviral) supplements, including certain herbs, minerals, amino acids, and other nutrients.

The list of approaches is not comprehensive. There exist other natural means supporting the body against viruses that are not specifically nutritional. For example, infrared saunas, hydrotherapy, and various forms of exercise support strong immunity and optimal health in the body. Many approaches are discussed in the HPDI Rejuvenation Program (see below) other than nutrition.

The Rejuvenation Program addresses various health-building practices, including preventing toxicity and detoxification (including related products like Intestinal Rejuvenation Formula and Hepa Plus) that can powerfully support good health. However, this article primarily focuses on nutritional approaches supporting the body defending itself against viruses.

ESTABLISH POWERFUL NUTRITION SUPPORTING THE BODY AGAINST VIRUSES

Establishing and maintaining good nutrition is perhaps the highest priority item when seeking to build optimal health. The kind of health necessary to keep the body and its immune system strong when exposed to viruses.

Winter Health Tea viruses flu colds

Hot herbal tea blends with cinnamon, turmeric, ginger, and lemon are helpful for winter flu and coughs.

THE HPDI REJUVENATION PROGRAM

HPDI offers ideas and suggestions for establishing and maintaining good health and strong immunity that can help you fight viruses.

Many of the ideas and programs are found in detail in the HPDI Rejuvenation Program. (You will hear a lot about that in this article.)

First and foremost, we believe health begins with diet and nutrition, including Foundational Supplements. This is the first part of the Rejuvenation Program.

HEALTHY DIET: WHOLE FOODS & SUPERFOODS

This article will not address diet in detail. However, the HPDI Rejuvenation Program generally emphasizes a balanced, varied diet, consisting of whole, high-density foods, including many vegetables and other plant foods. It favors organically grown and pesticide- and chemical-free foods. A certain level of raw foods is desirable.

The Rejuvenation Program is not prescriptive about what any given individual should eat. Individuals have different dietary needs depending on many factors, including age, level of exercise, blood type, metabolic type, food sensitivities, etc.

Certainly it is best to avoid consuming processed foods, refined foods, as well as high-sugar and other nutritionally depleted foods. In addition, the foods produced by industrial agriculture (i.e., foods containing synthetic pesticides, herbicides, and genetically modified (GMO) foods are best avoided. In addition, ingredients like artificial colors, flavors, preservatives, as well as deleterious additives, fillers, excipients and other non-nutrients or anti-nutrients.

Important dietary recommendations in the Rejuvenation Program include consuming fresh vegetable juices and smoothies, high-density foods (like chia seeds), and relatively high levels of dietary nucleic acids (like those found in Rejuvenate! superfoods).

In summary, the HPDI Rejuvenation Program recommends:

– A Balanced Diet

– Organic and Wild-Crafted, Nutrient-Dense Whole Foods

– Fresh Juices & Smoothies made with Organic Vegetables, Fruits, and Herbs

– Dietary Nucleic Acids (RNA, DNA) from natural sources like chlorella

– Superfoods, especially Rejuvenate!™ superfoods (high-RNA formulas)

– Sufficient Dietary Fiber (also see Intestinal Rejuvenation Formula)

– Alkaline-Forming Diet (high in plant-based foods)

– Eating Right For Your Blood Type (O, A, B, or AB)

– Appropriate routines for individuals, including exercise, yoga, massage therapy, acupuncture, hydrotherapy, as well as relaxation/meditation/biofeedback.

IMPORTANCE OF FOUNDATIONAL SUPPLEMENTS

What distinguishes HPDI’s Rejuvenation Program from other health and wellness programs,  supplement systems, diets, or detoxification protocols is its emphasis on a complete system of nutritional supplements and a comprehensive approach to supporting optimal health and well-being.

MAJORITY OF PEOPLE NUTRITIONALLY DEFICIENT

Many people take a daily multivitamin or essential fats, for example. Yet, the fact remains most people do not obtain all the nutrition they require either from foods or from supplements. One reason is that many people do not know which supplements or group of supplements they should take that constitutes a complete nutritional supplement program. Or they may not know the deficiencies from which they suffer.

The majority of people are deficient in magnesium, iodine, vitamin D, Vitamin E, B vitamins, nucleic acids, and other critical nutrients. Only a minority of individuals realize they are deficient, and even fewer take advantage of the availability of supplements to correct deficiencies, including those related to diet and nutrition.

HPDI system of Foundational Supplements rests on four pillars: 1) Multivitamins, 2) Antioxidant/Vitamin C formulas, 3) Essential Fatty Acid (EFA) formulas, and 4) Rejuvenate!™ superfoods (providing therapeutic levels of dietary nucleic acids, which Dr. Benjamin S. Frank asserts are nutrients essential for health).

HPDI offers multiple products in each category, all designed to provide high levels of essential nutrients. Among multivitamins, HPDI offers the Mighty Multi-Vite™ as a premier formula, but also offers products like Multi Two Tabs (which more economically provide similar levels of nutrients).

Likewise, HPDI offers Ultimate Protector and PRO-C™ as our premium antioxidant & Vitamin C formulas. Yet, we also offer Buffered-C (tablets) and Vitamin C (ascorbic acid) capsules that offer economy and potency.

foundational supplements viruses

HPDI Foundational Supplements are multivitamins, antioxidants/Vitamin C, essential fats, and Rejuvenate! superfoods.

Dietary nucleic acids are considered by many to be essential nutrients for health. HPDI currently offers three versions: Rejuvenate! PLUS, Rejuvenate! Berries & Herbs, and Rejuvenate! (original greens). Rejuvenate! superfoods are discussed in greater detail in Part Three and Part Four of the HPDI Rejuvenation Program. (Note: Rejuvenate! PRO and Rejuvenate! Strawberry–Peach Protein Plus are not currently available.)

The Greens Continuum Rejuvenate superfoods chlorella RNA viruses

Rejuvenate! superfoods vary in taste and ingredients, but all offer high levels of dietary nucleic acids.

These four types of foundational supplements provide a base for good health by giving the body the nutrients both required for establishing basic health and for supporting optimal health beyond a good diet. That is, they help ensure complete nutrient intake regardless of the type of diet a person consumes.

It is known that established government standards for nutrient intake are minimal at best (i.e., not optimal for human health). In addition, the principle of biochemical individuality shows that different persons require somewhat different levels of various nutrients. HPDI formulas are designed to offer maximal levels of essential nutrients safely and effectively. The intention behind the formulation of HPDI Foundational Supplements is supporting the optimal health of the invididual.

When individuals consumes the four basic foundational supplements, they gain a greater chance of meeting their unique nutritional needs. They also thereby provide the nutrients their body requires not only to sustain itself and create health, but also to defend itself by supporting optimal cell defense and immunity.

Learn more about the HPDI system of Foundational Supplements (http://www.integratedhealth.com/foundational-supplements/foundational-supplements.html).

BUILD STRONG IMMUNITY (AGAINST VIRUSES)

Building powerful immunity depends substantially on how well the body is nourished. That is, how completely the body receives the nutrition required to support its general good health and enable it to defend itself . But that is not all.

When it comes to defending the body against viruses, two specific types of formulas can play important roles beyond diet and foundational supplements. These are 1) immunity building formulas that include specific substances/nutrients known to support a robust immune system and 2) Formulas that include nutrients/herbs/substances acting as antivirals and antimicrobials in the body.

Many specific immune-building formulas/nutrients, as well as formulas acting as antivirals are included among HPDI’s Enhancement Formulas. These formulas include Immune-Assist™ (medicinal mushrooms), olive leaf extract, Cordyceps, Vitamin D3 Plus, Nascent Iodine, Selenium, Zinc, silver (SilverBiotics Polyvalent silver), and magnesium formulas. Some of these formulas are described in detail in Part Five of the HPDI Rejuvenation Program, as well as below.

Other immune-building foods/herbs and antiviral substances like echinacea and garlic are also part of the Rejuvenation Program. For example, echinacea is considered in Part Five, and garlic is discussed in Part Six as its own supporting protocol. Other supporting protocols include hydrotherapy and sauna therapy. Thus, most of HPDI’s immune-building and antiviral type formulas fall into either the category of Enhancement Formulas or Supporting Protocols. In a few cases, certain supplement formulas or recommended foods/herbs both build immunity and act directly as antivirals (e.g., garlic).

Note: there are other important nutrients like glutathione, quercetin, and certain liposomal forms of nutrients (e.g., vitamin C) that we won’t go cover in this article, but that can be useful for immunity against viruses. While this article is not intended to be comprehensive, our goal nevertheless is to provide resources that can help anyone seeking optimal health.

IMMUNE-BUILDING FORMULAS

As mentioned, immune-building formulas in the HPDI system usually fall into the category of Enhancement Formulas. Enhancement Formulas are the “next-level” of defense built upon the Foundational Supplements.

That is, after individuals have established high nutrient intake using foundational supplements, we typically recommend Enhancement Formulas next because of their unique capacities to support and build health.

While not all Enhancement Formulas specifically build immunity, most of them support health in ways that strengthen immunity. (Note: Another category of HPDI supplements is Specific Condition Formulas designed to address a specific problem or issue.)

While there are various immune-building formulas in the HPDI system, we focus on a select few in this article.

SELECTED ENHANCEMENT FORMULAS

IMMUNE-ASSIST™

Medicinal mushroom are proven immune boosters. When various species are combined in a single formula, the product provides the benefits of each type of mushroom. HPDI offers several medicinal mushroom formulas, including Immune-Assist™.

Immune-Assist™ contains a combination of more than 200 different polysaccharides, derived from the enzymatic breakdown of complex organic plant material from six different species of medicinal mushrooms. These include Agaricus blazeiCordyceps sinensis hybrid, Lentinula edodes (shiitake), Grifola frondosa (maitake), Ganoderma lucidum (Reishi), and Coriolus versicolor. Immune-Assist™ contains 500 mg per vegetarian capsule and is made in America using only USDA-certified organic materials.

Immune-Assist™ is similar to other mushroom-based polysaccharides in that it is formulated through an enzymatically activated process whereby complex cross-linked polysaccharides from vegetable sources are converted to biologically active immunomodulators composed of simpler sugars (such as arabinose and xylose). However, Immune-Assist™ offers significant advantages.

medicinal-mushrooms viruses

Immune-Assist includes Maitake, Cordyceps, Agaricus, Lenticula edodes, Coriolus versicolor, and Ganoderma lucidum.

While Immune-Assist™ contains simple polysaccharides, it also contains more complex polysaccharides, including cross-linked beta mannans and beta-glucans, and hetero-polysaccharides which combine both alpha-bound and beta-bound monosaccharides in the same molecule. These complex polysaccharide compounds are not found in earlier-generation, bran-based supplements like AHCC (Active Hexose Correlated Compound). This is the reason Immune-Assist™ shows such a greater range of immuno-modulation bioactivity than AHCC and other bran-based supplements.

Immune-Assist™ contains not only arabinoxylane, but also lentinan, grifolan (Dr. Nanba’s original Maitake D-Fraction), PSK and PSP, and active hemicellulose correlated compound (AHCC). There is about three times more arabinoxylane per dose of Immune-Assist™ than there is in MGN3, and four times more AHCC than in the ImmPower brand of AHCC.

Immune Assist viruses

Immune-Assist™ Daily Formula

Immune-Assist™ truly is a new and unique immune-boosting supplement. It has been tested in a number of different clinical trials. The results of one clinical trial indicate that mixed polysaccharides of medicinal mushrooms protect the hematopoietic (i.e., blood formation) function of bone marrow, induce the action of the digestive tract, boost the immunity of the cells, and increase the activity of the NK cells, LAK cells, and the ratio of Th to Ts cells.

Learn more about Immune-Assist™ (http://www.integratedhealth.com/hpdspec/immune-assist-daily-formula.html)

Another useful mushroom that is contained in Immune-Assist™, but which is effective on its own or used in conjunction with other immune-supporting substances is Cordyceps sinensis. HPDI carries Pure Cordyceps Capsules that can be used to support powerful immunity and provide a wide range of other benefits.

OLIVE LEAF EXTRACT

About a year ago, Fred wrote an extensive blog article title “Olive Leaf Extract: Antimicrobial Health Builder” in which he described many benefits of olive leaf extract (including its antiviral effects), as well as some of my personal experience with this formula. Check out that article for an extensive discussion of the benefits of olive leaf extract.

Olive Leaf viruses

Olive leaf extract exhibits antimicrobial activity.

HPDI’s Olive Leaf Extract formula contains 500 mg of the highest-quality patented olive leaf extract in a vegetarian capsule. This unique patented olive leaf extract is not inactivated by a blood protein due to its precise molecular rotation.

Olive leaf extract has a long history of strengthing health when microorganisms may be present. In recent years, a drug company discovered that in vitro (test tube) an extract from olive leaf (calcium elenolate) was effective in helping to control a very broad range of organisms.

The problem with using it in the body was that once in the blood, a protein combined with it and caused it to be inactivated. An American company in 1995 found that if the active molecule in olive leaf extract was rotated around a specific axis by a precise amount, the blood protein no longer inactivated it.

Olive leaf extract products without this unique molecular rotation are minimally effective in the body because they are inactivated by a blood protein after a short period of time (approximately 15 minutes).

Olive-leaf-extract viruses

HPDI’s Olive Leaf Extract provides molecular rotation for maximal effectiveness.

Many people report higher energy levels when using olive leaf extract. It has been shown to be extremely safe and non-toxic (even in large doses). See Olive Leaf Extract by Dr. Morton Walker for further information on its effectiveness and full range of applications.

Learn more about Olive Leaf Extract (http://www.integratedhealth.com/hpdspec/olivex.html)

Read Fred’s blog article Olive Leaf Extract: Antimicrobial Health Builder (http://www.integratedhealthblog.com/olive-leaf-extract-antimicrobial/)

VITAMIN D3 PLUS

Every week it seems, new studies report more information on the importance of Vitamin D for health. Among its many benefits: immunity boosting effects. Vitamin D has been shown to reduce the incidence of seasonal flu, for example. (See Vitamin D Abstracts in the resources section below.)

But it does so much more. That’s why we include it as an HPDI Enhancement Formula and have designed our own product that includes vitamins A and K2 (as MK-7) known to improve utilization of vitamin D in the body.

Vitamin D3 Plus is an advanced Vitamin D formula providing high-dose Vitamin D3. Vitamin D3 is the natural form of Vitamin D produced in the body from sunlight and is the form best used for therapeutic purposes.

One softgel capsule of Vitamin D3 Plus provides 5,000 IU of Vitamin D3 derived from highly purified and molecularly distilled fish liver oils. In addition, the product contains 1,000 IU of Vitamin A also derived from highly purified and molecularly distilled fish liver oils and 10 mcg of Vitamin K2 from menaquinone-7.

Vitamin D3 Plus includes synergistic nutrients known to enhance absorption and use of Vitamin D3 in the body. These nutrients include Vitamin K2 (menaquinone-7) (10 mcg), which which works together with Vitamin D to help boost bone density, improve cardiovascular health, and boost immunity.

Vitamin D3 Plus also provides 1,000 IU of Vitamin A, a nutrient known to work powerfully with Vitamin D to help create optimal health. As dosages of Vitamin D increase, ideally your dosage of Vitamin A also will increase, and vice versa. The formula also includes natural Vitamin E as an antioxidant.

vitamin d3 plus doctor hank liers original viruses

Vitamin D3 Plus includes vitamins A and K2 (as MK-7).

Vitamin D3 is a fat-soluble vitamin increasingly known as a nutrient essential for health and well-being. Recent studies show that almost all body systems benefit from adequate Vitamin D intake/production. Therefore, it is important that the body receive optimal amounts in order to build the best health.

In fact, recent studies indicate that 5,000 IU of Vitamin D3 is an ideal amount for daily intake. What is notable about this amount is that the body does not gain the full benefits from Vitamin D until it reaches this “threshold” level of 5,000 IU While the body stores Vitamin D, it must first be given an adequate supply.

Vitamin D deficiency currently is a worldwide epidemic with more than one billion people at risk for diseases associated with low Vitamin D status. Vitamin D is proven safe and effective for a wide range of health conditions (see above and below). There are various reasons for this epidemic, including a significant portion of the world’s population living in northerly latitudes (where sunlight is inadequate during many months of the year), sun avoidance, time spent indoors, etc.

Vitamin D3 Plus provides only the Vitamin D3 form of Vitamin D. We avoid the use of Vitamin D2. Vitamin D2 has greater potential for toxicity, poorer absorption, and reduced effectiveness.

Learn more about Vitamin D3 Plus (http://www.integratedhealth.com/hpdspec/vitamin-d3.html)

NASCENT IODINE

Nascent Iodine is the ideal form of iodine, rapidly absorbed and used by the body when taken as a nutritional supplement. Iodine is associated with a wide range of benefits, not limited to supporting thyroid function and regulating metabolism, boosting energy levels (when iodine is deficient), supporting and maintaining detoxification systems and processes, supporting immune system function, fighting infections (natural antiseptic), and many other healthy benefits. Because of its antiseptic properties, it also can be used effectively to purify water for drinking. One drop provides 400 micrograms of Nascent Iodine in a base of certified Biodynamic® grape alcohol.

Biochemically, Nascent Iodine  is consumable iodine in an atomic form rather than a molecular form. It is highly bioavailable as a pure atomic iodine supplement in an energized state. This “charged” state is held by the atom until diluted in water and consumed, whence it gradually loses energy over a 2–3 hour time span. During this time, Nascent Iodine is recognized by the body as the same iodine that is used by the thyroid and is absorbed effortlessly by the body. As noted, this particular form of iodine is unique and well known to offer beneficial effects unlike any other form of iodine.

nascent iodine formula viruses

Nascent Iodine supports immunity, thyroid health, and provides many other benefits.

Partly due to the fact that iodine supports (and is required for) thyroid function, the uptake of adequate amounts of iodine helps the body produce substantial levels of energy for metabolic processes. It is notable that twenty-five percent of the iodide ions found in the human body are found in the thyroid gland.

It is estimated that more than 90% of Americans suffer from a deficiency of iodine. There are many causes for widespread deficiency among the population. Some significant factors include diets lacking in ocean fish or sea vegetables (e.g., seaweeds), high intake of bromine (which is added to commercial breads and baked goods), and vegetarian or vegan diets (see more below), all of which may contribute to lower than optimal levels of iodine.

Moreover, it is known that toxic halides, including chlorine, fluorine (e.g., fluoride in toothpaste), and bromine (e.g., in breads) compete for uptake with iodine in the body, thereby contributing to iodine deficiency.

Iodine deficiency can lead to the development of many adverse health conditions (and a wide variety of symptoms) because the entire body (i.e., all organ systems) depends upon iodine for the critical roles it plays energy production, healthy metabolism, and overall support of health.

The importance of iodine to the biological function of the body traditionally focused on the role of iodine in the nourishment of the thyroid gland, particularly for the production of T3 and T4 hormones, and the regulation of metabolism.

However, as the understanding of this nutrient progresses, we have come to understand that the roles of iodine in the body far surpass those roles it has been believed to fulfill. Iodine is not only necessary for overall health, but also is a crucial component of detoxification processes critical for sustaining life and health.

Learn more about Nascent Iodine (http://www.integratedhealth.com/hpdspec/nascent-iodine.html)

POLYVALENT SILVER

Colloidal silver is a proven antimicrobial. It is highly effective against a broad range of viruses, bacteria, and fungi. It can help you combat these microbes.

HPDI offers a Silver Biotics® product made using a patented method to produce nano-silver particles suspended in a medium of highly purified water. The Silver Biotics® particles have been defined as a metallic nano-silver particle with a thin coating of polyvalent silver oxide.

silver-biotics polyvalent silver viruses

Polyvalent silver supports and maintains health naturally.

The patented production method supercharges the silver particles using 10,000 volts AC, whereas other colloidal silver solutions are typically only charged with 100 volts DC. This supercharging results in 2 electrons being removed from the outer shell of the silver atom giving it a +2 ionic charge compared to a +1 ionic charge for other colloidal silvers.

Because the ionic charge is one of the primary mechanisms by which silver particles work, the Silver Biotics® particles are significantly more effective than conventionally produced colloidal silver.

The patented production method used in creating Silver Biotics® polyvalent silver produces a unique electron configuration that gives the silver particles the catalytic ability to recharge and regenerate themselves over and over again. This gives each silver particle in the Silver Biotics® solution the ability to be used multiple times as opposed to the one time use of the particles produced by most other colloidal silvers.

Research also shows that conventionally produced colloidal silvers have a bioavailability of 15–65%, whereas the Silver Biotics® polyvalent silver has a bioavailability of over 99%. The ability of the Silver Biotics® polyvalent silver particles to be used multiple times along with the high bioavailability means that the Silver Biotics® is significantly more effective than other colloidal silver products even at the lower concentration of 10 ppm.

The silver particle size range in Silver Biotics® is between 0.005 and 0.015 microns. The particles are suspended in a solution of double distilled water. Our manufacturer has chosen a safe FDA approved plastic container for the Silver Biotics®. Research studies have shown that glass containers cause the polyvalent silver particles to plate out or precipitate from solution and reduce the product’s effectiveness by about 50%.

Tests performed at multiple research laboratories have shown that Silver Biotics® is highly effective against a broad range of bacteria, fungi (including Candida albicans), and viruses. Because Silver Biotics® does not target specific mechanisms, receptor sites, or metabolic processes, it is unlikely that mutations of the microbes will produce resistant strains (as antibiotics often do)!

In addition to its antimicrobial properties, Silver Biotics® has been shown to be a potent anti-inflammatory agent. Furthermore, there is powerful evidence that Silver Biotics® improves the state of the body’s immune system.

Silver Biotics® can be applied topically or taken internally. Also, it can be used as a topical disinfectant. Studies have demonstrated that it is highly non-toxic, even at high levels of ingestion (5g/kg of body weight). Furthermore, research studies by major research groups have shown that Silver Biotics® solutions are not cyto-toxic and do not kill friendly probiotic bacteria.

Learn more about Silver Biotics® Polyvalent Silver (http://www.integratedhealth.com/hpdspec/silver-biotics-polyvalent-silver.html)

MAGNESIUM, ESPECIALLY MAGNESIUM CHLORIDE (MgCl2)

Magnesium is one of the most important minerals for health. It offers so many benefits that it would be difficult describe them briefly. However, suffice it to say that magnesium supports immunity, energy (ATP) production, vascular health, and total body wellness. Yet, nearly everyone (greater than 90% of Americans) is deficient.

HPDI offers several types of magnesium supplements. We offer a full range of Ancient Minerals topical magnesium chloride products, including magnesium oil, as well as flakes and gel. We also offer Myo-Mag, a unique combination of magnesium, malic acid, and synergistic nutrients.

Topically applied magnesium chloride formulas are among the most effective at rapidly elevating magnesium levels in the body. Magnesium provides significant health benefits to the body, including immune-boosting effects.

Magnesium dead sea viruses

Magnesium-rich water provides the body with rapidly assimilable magnesium.

Magnesium is necessary for the production of energy (ATP or Adenosine Triphosphate) in the body. When the body receives adequate amounts of magnesium, it can produce the levels of energy required to sustain the body and enable it to thrive. It is precisely because energy (as ATP) is required for the health of human organism that the critical role magnesium plays in energy production is gaining increased recognition by individuals interested in nutrition and natural health. All organ systems depend on energy. A mineral nutrient (i.e., magnesium) that can increase cellular energy thereby has the capacity to improve the health of the entire human body (i.e., all organ systems) via providing the energy for sustaining them all.

Magnesium is critical for cell metabolism. It helps to transport other minerals across cell membranes and affects cell mechanisms controlling muscle and nerve cell activity.

Magnesium specifically is important for the metabolism of many biologically active nutrients and substances, including calcium, potassium, phosphorus, zinc, copper, sodium, lead, cadmium, hydrochloric acid (HCl), acetylcholine, and nitric oxide (NO). It is required for more than 325 magnesium-dependent enzymes, cellular homeostasis, and activation of the B vitamin thiamin. It mediates the functions of the nervous and endocrine systems, supports proper muscle and nerve function, stabilizes heart rhythm, helps to regulate blood sugar levels, and supports normal blood pressure. As noted, magnesium is important in energy metabolism and the synthesis of proteins. The majority of magnesium within the nucleus of cells is closely connected with nucleic acids and mononucleotides. In fact, magnesium helps to maintain the structural integrity of DNA.

Unlike any other form of magnesium, magnesium chloride is a known infection fighter. As early as 1915, the French surgeon, professor of clinical surgery, and French Academy of Sciences member Dr. Pierre Delbet (1861–1957) used magnesium chloride solution to cleanse wounds in soldiers injured during the First World War. He had searched for an antiseptic that could disinfect wounds, but would not damage tissue (and thereby encourage mortification) as did other antiseptics then available. He reported that magnesium chloride was superior to traditional antiseptics not only in its effectiveness in treating wounds, but also because it did not harm body tissues.

Dr. Delbet discovered that magnesium chloride solution increased leucocyte activity and phagocytosis (i.e., the destruction of pathogenic microbes) when applied externally (i.e., used transdermally). He performed numerousin vitro and in vivo studies using magnesium chloride solution. These experiments led to his discovery that magnesium chloride was a potent immune stimulant whether applied externally (i.e., transdermal application), injected intravenously, or taken by mouth (i.e., consumed orally). He termed this immunity boosting effect “cytophilaxis” (a cytophylactic is a substance that protects cells and encourages their healthy growth). In this regard, he observed increased phagocytosis (the engulfing of pathogens by white blood cells) by up to 300 percent. That is, white blood cells were three times more effective at destroying microbes than before administration of magnesium chloride.

The pioneering efforts of Dr. Delbet were followed in the 1940s by fellow French physician Dr. A. Neveu. Dr. Neveu confirmed the immuno-stimulant effects of magnesium chloride, and he successfully tested magnesium therapy for wide range of conditions. These conditions included colds and flu, throat infections of the tonsils and pharnyx, lung and respiratory conditions, gastrointestinal inflammation (stomach flu), skin infections, septic wounds, and many common childhood conditions. More recently, other physicians such as Dr. Raul Vergini in Italy have confirmed the results reported earlier by Dr. Delbet and Dr. Neveu. Dr. Vergini reports excellent results using small quantities of orally administered magnesium chloride solution (2.5 percent magnesium chloride) both for proven applications developed by Dr. Delbert and Dr. Neveu, and for a broad range of other health conditions.

magnesium oil 64 ounces viruses

Magnesium oil provides an ideal means to increase magnesium levels in the body.

Additional benefits of magnesium oil include greater energy, more relaxed muscles (and stronger connective tissues), better sleep, improved mental function, headaches reduced (or eliminated), arterial health, better reproductive function, and better hormonal balance for men and women (and reduced PMS). In addition, magnesium maintains the flexibility of cell membranes for improved intercellular communication, greater uptake of bioactive substances (e.g., micronutrients, neurotransmitters, and hormones), and detoxification of toxins and metabolic waste products. Magnesium oil also acts as an effective full body tonic. Dr. Sircus asserts that transdermal magnesium therapy is among the very best ways to improve human health.

Learn more about topically applied Ancient Minerals magnesium chloride (http://www.integratedhealth.com/hpdspec/magnesium-oil.html)

Magnesium chloride products comparison chart

Myo-Mag synergistic magnesium and malic acid formula.

Other useful minerals for supporting immunity include selenium and zinc. HPDI offers Selenium (from l-selenomethionine) and Double Zinc Plus to cover your needs for these important minerals.

VITAMIN C

Vitamin C is a Foundational Supplement in the HPDI supplement system. That is, we consider it more fundamental than an Enhancement Formula, and so ideally everyone takes Vitamin C daily as part of a set of foundational supplements. I’m discussing it here because it plays a significant roles as immune-booster, and because the body may benefit from additional amounts of Vitamin C as a means of supporting health when fighting viral infection.

If you’re not already taking Vitamin C as part of your daily basic (i.e., foundational) supplements, then be sure either to add it to your supplement regimen or at least increase your intake during times you’re likely to be exposed to viruses.

Never forget the power of Vitamin C to benefit health, including support for strong immunity. Nobel prizewinner Dr. Linus Pauling documented the manifold benefits of this essential nutrient. If you read his research (in his books like How to Live Longer and Feel Better), you will see there is good reason why Vitamin C is classified a “vitamin” because without it we cannot survive.

Tangerine Segments viruses

Vitamin C rich foods include citrus fruits, peppers, and certain berries.

Dr. Pauling extolled the efficacy of Vitamin C in his many books, including How to Live Longer and Feel Better. We highly recommend this highly accessible work (even it that’s the only one you read) as he wrote it for a general audience. Or peruse his landmark Vitamin C and the Common Cold for additional perspective.

We include Vitamin C in our HPDI Foundational Supplement system precisely because of its critical role for basic health, healing, and wellness. HPDI offers a range of Vitamin C products.

These formulas include our premier PRO-C™ super antioxidant formula and Ultimate Protector Nrf2 antioxidant formula. We also offer Buffered C tablets and powder, as well as ascorbic acid capsules.

ultimate-protector-sm viruses

Ultimate Protector Nrf2 activator formula provides vitamin C, antioxidants, and Nrf2 activators.

SUPPORTING PROTOCOLS

The HPDI Rejuvenation Program includes various other means for supporting the body, including the immune system, against viruses and for good health generally.

As noted, one of the Supporting Protocols is the Garlic Program. Yet, other subprograms discussed include hydrotherapy and saunas, massage, acupuncture, and yoga.

We include these because building strong immunity almost always involves more than just diet, nutritional supplements, and a positive outlook. Incorporating various forms of exercise, relaxation, mindfulness and meditation, and traditional healing arts are proven means to support good health. And help to support immunity in ways that can help fight the viruses and other microbes that take advantage of weak immunity and undermine our health.

CONCLUSION

There are many things individuals can do to support powerful immunity that can help protect the body against viruses. In fact, there are many additional nutrients we haven’t discussed here. Suffice it to say that there are many natural nutrients, herbs, and other substances that can effectively support immunity and wellness in the face of exposure to viruses.

SOURCES & RESOURCES

FOUNDATIONAL SUPPLEMENTS

HPDI Foundational Supplements

Why You Need Foundational Supplements

Ultimate Protector and the Role of Foundational Supplements for Health

Foundational Supplements: Rejuvenation Program: Part Four

Vitamin C — An Amazing Nutrient by Dr. Hank Liers

Questions & Answers about Ultimate Protector

Review of Scientific Research on Oligomeric Proanthocyanidins (OPC)

HPDI REJUVENATION PROGRAM

HPDI Rejuvenation Program

RELATED HPDI BLOG ARTICLES

HPDI Radiation Protocol

Why Nutritional Supplements are Vital for Optimal Health by Hank Liers, PhD

Dietary Nucleic Acids – Dr. Benjamin S. Frank, Part 1 by Fred Liers, PhD

Dietary Nucleic Acids – Dr. Benjamin S. Frank, Part 2 by Fred Liers, PhD

Immune Strengthening using Medicinal Mushrooms by Hank Liers, PhD

Olive Leaf Extract: Antimicrobial Health Builder by Fred Liers, PhD

Vitamin D3 — Superstar by Hank Liers, PhD

A Vitamin Medicine Timeline by Fred Liers, PhD

Vitamin D for Health (Review) by Fred Liers, PhD

Vitamin D Abstracts

BOOKS & READING

How to Live Longer and Feel Better by Dr. Linus Pauling

See HPDI’s List of Recommended Reading