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A QUESTION ABOUT THE PURITY OF FISH LIVER OIL IN VITAMIN D3 PLUS

Dr. Hank Liers, PhD vitamin D3 Plus question answer

I often receive questions about various HPDI products. This month, I want to answer a question I got about our Vitamin D3 PLUS supplement.

It is my hope that periodic answers to your questions may help others when making choices regarding nutritional supplements. HPDI always strives to formulate the highest purity and highest quality supplements available. Please read about our four-pillar Approach to Formulation.

 A QUESTION ABOUT THE PURITY OF FISH OIL IN VITAMIN D3 PLUS

QUESTION: I see the source of the Vitamin D3 and Vitamin A in the product is fish liver oil. Are there any test results available for mercury or other heavy metals?

HANK: I am always careful when formulating any product to minimize any potential toxins. Vitamin D3 and Vitamin A from fish liver oils, as are found in the HPDI Vitamin D3 Plus formula, are highly concentrated sources which means that only milligram amounts are needed. That by itself means there would be very low levels of toxins.

This fact is verified by independent testing that shows mercury levels of less than 0.003 ppm, lead levels of less than 0.005 ppm, cadmium levels of less than 0.002 ppm, and arsenic levels of less than 0.004 ppm. “Less than” means the amounts are below the detection limits! Very low levels, indeed. View the test results below.

Test Results:

1. Test results for Cadmium, Mercury & Lead: https://www.integratedhealth.com/downloads/d3Test1.pdf

2. Test results for Inorganic Arsenic: https://www.integratedhealth.com/downloads/d3Test2.pdf

 

vitamin d3 plus

The fish liver oils in Vitamin D3 Plus are exceptionally high in purity.

MORE ABOUT VITAMIN D3 PLUS

Vitamin D3 PLUS is formulated as an advanced Vitamin D3 formula. It incorporates various cutting-edge design features and offers many benefits. Here are some relevant facts about HPDI’s Vitamin D3 PLUS:

• The formula provides Vitamin D3 (cholecalciferol) from highly purified fish liver oil. We avoid the use of Vitamin D2 because of a greater potential for toxicity, poorer absorption, and reduced effectiveness. Furthermore, we prefer Vitamin D3 in a softgel form. In softgels, the oil is incorporated without using other ingredients (like corn starch) used for microencapsulation to make Vitamin D into a powder that is then put into a capsule. HPDI avoids using fillers and excipients in products whenever possible. (See A Pure Approach to Formulation for our four pillar system of supplement design).

• Vitamin D research during the last 10 years shows an optimal amount of supplemental Vitamin D for most people of about 5,000 IU. This is what is generally needed to get blood levels of Vitamin D to the level of 50–80 ng/ml (nanograms per milliliter).

• Non-GMO sunflower lecithin acts as an emulsifier of Vitamin D and ensures effective absorption of the Vitamin D in Vitamin D3 PLUS. In addition, the use of rice bran oil further supports absorption of fat-soluble Vitamin D. Optimizing absorption of Vitamin D is critical especially in cases of Crohn’s disease, Celiac disease (gluten intolerance), and irritable bowel syndrome.

• Because the oils involved are susceptible to oxidation, we include Oryza rice bran oil in Vitamin D3 PLUS. Oryza rice bran oil contains significant amounts of Vitamin E (in the form of mixed tocotrienols and tocopherols) that prevents oxidation.

• Vitamin D3 is combined with Vitamin A because they act synergistically. It is known that high dose Vitamin A without Vitamin D can cause bone loss. However, there is no observed bone loss when adequate Vitamin D (more than 2,000 IU daily) is taken together with Vitamin A. Chris Masterjohn eloquently discusses this topic in his seminal article “Vitamin A on Trial: Does Vitamin A Cause Osteoporosis” (see Weston A. Price Foundation website). Also, Masterjohn states that Vitamin A taken in conjunction with Vitamin D is necessary for proper bone remodeling. We include 1,000 IU of Vitamin A along with Vitamin D3 in Vitamin D3 PLUS.

• Vitamin K2 (especially as Menaquinone-7) is necessary for the proper activation of bone matrix proteins by conferring upon them the physical ability to bind calcium. Chris Masterjohn has beautifully discussed this issue in his paper “On the Trail of the Elusive X-Factor: A Sixty-Two–Year-Old Mystery Finally Solved” (see Weston A. Price Foundation website). Because Vitamin K2 is needed to facilitate the function of Vitamin D in proper bone formation (including teeth), Masterjohn states that Vitamin D toxicity is most likely a case of Vitamin K2 deficiency.

• In their book Health Benefits of Vitamin K-2, Larry M. Howard and Anthony G. Payne assert that as little as six mcg of Vitamin K2 (as MK-7) can be beneficial to the body. We therefore include 10 mcg of MK-7 per softgel in Vitamin D3 PLUS. In addition, research has shown that Vitamin K2 can help remove calcium from soft tissues in the body and instead put the calcium into bony structures. Vitamin K2 is found naturally in fermented foods such as cheeses, sauerkraut, dairy products, natto (i.e., a traditional Japanese dish of fermented soybeans), and in dairy products, eggs, and certain meats.

• In light of recent research on Vitamin D, we recommend most people take 5,000 IU of Vitamin D3 daily (unless there is some constraining lifestyle factor or compelling medical reason). Due to its long half-life (about 30 days) in the body, Vitamin D3 PLUS can be taken effectively in smaller doses if needed (e.g., 5,000 IU taken fewer times per week). For example, taking one capsule once per week would give a daily equivalent dose of about 714 IU (i.e., 5,000 IU divided by seven days).

• Other nutrients ideally taken with Vitamin D3 in order to achieve maximum benefit include magnesium, calcium, zinc, and boron. These additional nutrients are included in HPDI’s foundational supplements and bone formulas (Bone Jour!, Bone Guardian, and Cal/Mag Plus).

vitamin d3 plus purity quality

Testing helps ensure the purity and effectiveness of HPDI products.

SURPRISING VITAMIN D3 FACTS

• A human being optimally produces 10,000–20,000 IU of Vitamin D3 (cholecalciferol) when exposed to full sunlight on a significant portion of skin for about 30 minutes.

• The body only starts to get the full benefits of Vitamin D3 after it has produced or taken orally about 5,000 IU daily.

• In this world of sun avoidance, sun blocks, working indoors, latitudinal effects, etc. a majority of the population suffers in multiple ways from deficiency (or less than optimal levels) of Vitamin D3.

• Vitamin D3 is actually a steroid hormone with very powerful effects and, with few exceptions, cannot be obtained in sufficient amounts from your diet.

GOT QUESTIONS ABOUT HPDI PRODUCTS?

We at HPDI welcome questions about our products. Please use our contact webform or email your questions to: support(at)integratedhealth.com.

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Description and Comparison of ORAC Tests for Well Known Plant Ingredients and Ultimate Protector™

Hank Liers ORAC testsThe term “ORAC” (standing for “Oxygen Radical Absorption Capacity”) describes a test developed by Brunswick Labs as an analytical tool for estimating the antioxidant capacity of substances. The measurement of ORAC value involves an in vitro test of the capacity of a substance to trap peroxyl radicals. Brunswick Labs remains a leader in the development of ORAC tests.

The development of the ORAC test was an important advancement in commercially available analysis of the capacity of various foods and ingredients to trap the peroxyl radical. It has become a de facto standard in the natural products industry. However, the original ORAC method was considered to be just a starting point for comprehensive antioxidant analysis.

The arrival of more comprehensive ORAC tests like Brunswick Labs’ ORAC5.0™ test (also known as ORAC-FN) measuring the antioxidant capacities of five different types of oxidants allows more accurately determination of the total antioxidant quenching power of substances. This helps to better assess the effectiveness of existing antioxidant formulas, and supports development of improved formulas that provide a broad range of antioxidant foods and nutrients that combat all major types of free radicals.

Ultimate Protector - nrf2 activator

FIVE TYPES OF FREE RADICALS AND OXIDANTS

Peroxyl, Hydroxyl, Peroxynitrite, Superoxide Anion, Singlet Oxygen

The fact is that there are a variety of “free radicals” that operate in humans — the most important of which are the primary radicals peroxyl, hydroxy peroxynitrite, superoxide anion, and singlet oxygen. Brunswick Labs has reported that even though the peroxyl radical is the major free radical in the body, it represents no more than 27% of the total antioxidant potential of selected fruits and vegetables. In addition, the original ORAC method favors certain antioxidant substances over others (e.g., anthocyanins over carotenoids) due to the use of a single free radical source (i.e., the peroxyl radical).

Various free radicals are formed, behave, and are defended against differently. They all contribute to 1) a general condition called “oxidative stress,” or cellular damage and 2) broad human health concerns caused, for example, by inflammation, DNA and protein damage. They are each implicated in different health problems — from cardiovascular disease to macular degeneration and Alzheimer’s disease and to skin damage and aging. We provide a brief summary of these free radicals (below).

The Peroxyl Radical is very important in many biological systems, including lipid peroxidation, DNA cleavage, and protein backbone modification. Hydroxyl is highly reactive and cannot be eliminated by our endogenous enzymes (such as SOD and glutathione). It can damage virtually all types of macromolecules: carbohydrates, nucleic acids, lipids, and amino acids. In the skin, hydroxyl radicals are created by UV exposure. Peroxynitrite is a reactive nitrogen species that is particularly harmful to proteins. It has been implicated in the development of certain cancers, hepatitis, and chronic inflammation. In the skin, peroxynitrite contributes to the breakdown of vital proteins, such as collagen.

Superoxide Anion is a precursor of all other reactive oxygen species and sometimes is referred to as “the mother of free radicals.” It is highly toxic and contributes to lipid and DNA damage. Antioxidants that scavenge superoxide anion also help prevent the formation of radicals such as hydrogen peroxide and hydroxyl. Superoxide anion has been linked to hypertension and cardiovascular damage. Singlet Oxygen is generated in the skin by by UV. In vivo, it is linked to the oxidation of LDL cholesterol and cardiovascular disease. Singlet oxygen is highly unstable and durable. Carotenoids are very effective at scavenging singlet oxygen.

The importance of an ORAC test that measures the effectiveness of antioxidant foods, phytochemicals (e.g., polyphenols), vitamins, and other food-based substances against a broader range of free radicals (i.e., beyond the peroxyl radical) becomes apparent when considering how these antioxidants operate in the body. The body faces a diverse group of oxidants, so any test that can provide an estimate of how well a given set of antioxidants will protect cells in reality will also provide a distinct advantage for designing superior antioxidant formulas.

A NEW, MORE COMPREHENSIVE ORAC TEST: ORAC5.0™

Brunswick Labs recently introduced a new, more comprehensive form of ORAC test called ORAC5.0™ (also known as ORAC-FN). This test expands the ORAC platform to measure the antioxidant capacity against each of the five primary reactive oxygen species mentioned above. ORAC5.0™ substantially improves broad-spectrum antioxidant analysis and gives evidence of the diverse antioxidant potential of natural products against radicals other than just the peroxyl radical. Brunswick Labs’ research shows that the antioxidants found in a wide range of natural products are effective against these primary radicals, and that in many cases a preponderance of a product’s antioxidant capacity is described by performance against the four new radicals added to the new ORAC5.0™ panel (which is now the king of ORAC tests).

Table 1.0 (below) shows ORAC5.0™ test results for a range of natural substances known to have significant health benefits and that are broadly used in nutritional supplements. In general, these substances are included at mg levels in supplement formulas. For example, maximum per serving amounts are about 20 mg for astaxanthin, 400 mg for bilberry 25%, 100 mg for grape seed/fruit, 200 mg for green tea extract, 200 mg for coffee berry extract, 100 mg for pine bark, and 100 mg for resveratrol. Considering this the number of total ORAC5.0™ units consumed per serving would typically be in the range of 1,000 to 30,000. Also, it is important to observe that with the exception of green tea extracts none of these ingredients gives excellent protection from the peroxynitrite radical and even green tea extract at the level of 200 mg daily only gives a peroxynitrite radical ORAC value of 400 units.

ULTIMATE PROTECTOR™ DEMONSTRATES HIGH ORAC5.0™ VALUE

In the table, we have also included the results for HPDI’s new ULTIMATE PROTECTOR™ cell protection formula. It can be seen that ULTIMATE PROTECTOR™ has a total ORAC5.0™ value that is more than 50% greater than green tea extract and many times greater than most of the other ingredients. Table 2.0 shows the total ORAC5.0™ units per daily serving. Because the daily recommended serving for ULTIMATE PROTECTOR™ is 2.8 grams (six small capsules), the total daily ORAC5.0™ measures 486,000 units! This value is over 10 times greater than you receive from typical serving sizes of the ingredients shown in the table!! In addition, ULTIMATE PROTECTOR™ provides excellent protection against all five of the free radical types in the body — something none of the specific ingredients do well!!

Table 1.0 ORAC5.0™ Comparative Results

Ingredient Peroxyl Radical Hydroxyl Radical Peroxy-nitrite Radical Super-
oxide Radical
Singlet O2 Radical Total ORAC5.0
Astaxanthin 1,000 9,000 10,000
Bilberry 25% 7,000 25,000 1,000 16,000 5,000 54,000
Cocoa 10,000 28,000 1,000 11,000 2,000 52,000
Grape Seed/Fruit 17,000 47,000 1,000 25,000 4,000 94,000
Green Tea 11,000 41,000 2,000 56,000 3,000 113,000
Coffee Berry 5,000 29,000 1,000 1,000 2,000 38,000
Mangosteen 4,000 8,000 1,000 18,000 4,000 35,000
Pine Bark 7,000 23,000 1,000 17,000 2,000 50,000
Resveratrol 12,000 50,000 1,000 8,000 22,000 93,000
ULTIMATE PROTECTOR 6,300 5,900 2,500 106,000 52,000 173,000
Results are expressed in micro mole TE/g

Table 2.0 ULTIMATE PROTECTOR™ ORAC Units Per Serving

ORAC5.0 Units Per Serving* Free Radical Type
17,700 Peroxyl Radical is very important in many biological systems, including lipid peroxidation, DNA cleavage, and protein backbone modification.
16,500 Hydroxyl is highly reactive and cannot be eliminated by our endogenous enzymes. It damages virtually all types of macromolecules: carbohydrates, nucleic acids, lipids, and amino acids. In the skin, hydroxyl radicals are created by UV exposure.
6,900 Peroxynitrite is a reactive nitrogen species that is particularly harmful to proteins. It has been implicated in the development of certain cancers, hepatitis, and chronic inflammation. In the skin, peroxynitrite contributes to the breakdown of vital proteins, such
as collagen.
146,000 Singlet Oxygen is generated in the skin by UV exposure. It is linked to the oxidation of LDL cholesterol and cardiovascular disease.
299,000 Superoxide Anion is a precursor of all other reactive oxygen species – sometimes referred to as “the mother of free radicals.” It is highly toxic and contributes to lipid and DNA damage.
486,000 Total Per Daily Serving of Six Capsules (2.81g)

Review the Brunswick Labs Ultimate Protector™ ORAC5.0™ Test Report Here

ADDITIONAL RESOURCES

 Questions & Answers about Ultimate Protector

The Amazing Healing Potential of Natural Nrf2 Activators

Ultimate Protector™ and the Role of Foundational Supplements for Health

New Directions For Preventing Free-Radical Damage

Natural Phytochemical Nrf2 Activators for Chemoprevention

Ultimate Protector™ Brunswick Labs ORAC5.0™ Test Results

Description and Comparison of ORAC Tests for Well Known Plant Ingredients and Ultimate Protector™

Ultimate Protector™: First Impressions

Ultimate Protector™ ORAC5.0™ Test Results

Preventing Free-Radical Damage Using Ultimate Protector™

New Directions for Preventing Free-Radical Damage

Natural Phytochemical Nrf2 Activators for Chemoprevention

Ultimate Protector flyer (.pdf)