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PRO-C ANTIOXIDANT FORMULA UPDATE + VIDEO

Dr. Hank Liers, PhD pro-c™ pro-c super antioxidant formulaFred Liers PhD pro-c antioxidant vitamin c nrf2 formulaLooking for an advanced antioxidant formula? Already using or recommending vitamin C? Curious about cellular Nrf2 activation? Look no further than PRO-C™.

PRO-C™ is among the most effective antioxidant formulas available. It is an HPDI foundational supplement that works most effectively when used with multivitamins, essential fats, and superfoods. However, it is also an excellent standalone formula that can rapidly provide the body with extremely high protection from free radicals.

We ourselves have taken PRO-C daily for many years with excellent results. Our personal experience together with detailed feedback from health professionals and end-users affirms the effectiveness of PRO-C as a super-antioxidant–vitamin C-Nrf2 activator formula.

PRO-C provides 500 mg of buffered vitamin C per capsule (buffered with calcium, magnesium, and zinc) along with grape extract (seed, skin, pulp) and green tea extract (95% polyphenols). In addition, we include a special combination of the “network antioxidants” l-glutathione (reduced), n-acetyl-l-cysteine (NAC), r-lipoic acid, and selenium. Vitamin B2 and Vitamin B6 in coenzyme forms support the enzymatic effectiveness of the “network antioxidants”. The formula works so well because this combination of ingredients leverages the antioxidant power of vitamin C, grape extract, green tea extract, and the other nutrients to act synergistically in order to maximize effectiveness.

FORMULATION HISTORY AND THE SCIENCE BEHIND PRO-C™

What you may not know is the history of the development PRO-C and the scientific knowledge on which Dr. Hank Liers based his formulation of it.

Dr. Hank formulated his first product in 1989. It was a potent antioxidant formula he called PYC-C™ (sounds like “pixie”). PYC-C consisted of a combination of buffered Vitamin C (including magnesium, calcium, and zinc ascorbates) and pycnogenols from pine bark.

Much of the scientific research data Dr. Hank collected during the development of PYC-C regarding oligomeric proanthocyanidins (OPC) he later incorporated into an article (currently published on this blog) titled “Review of Scientific Research on Oligomeric Proanthocyanidins (OPC)” (rev. 2017)

By 1997 Dr. Hank had gathered a great deal of new scientific information regarding green tea catechins and the nutrients termed “network antioxidants” by Dr. Lester Packer, director of Packer Lab at University of California, Berkeley. Beyond this information, Dr. Hank studied additional research regarding how various nutrients worked together synergistically. At that point, he was ready to formulate the new, improved PRO-C™ super antioxidant formula.

PRO-C combines the ingredients of PYC-C (now known as OPC-C™) and uses grape pulp, skin, and seed extract with green tea extract (with high polyphenols >95% and EpiGalloCatechinGalate (EGCG) >45%), n-acetyl-l-cysteine (NAC), reduced glutathione (GSH), R-lipoic acid, selenium, and coenzyme Vitamins B2 and B6.

PRO-C super antioxidant formula 180 cap 90 cap

HPDI launched PRO-C™ in late 1997. It rapidly became one of our best-selling products. Our customers raved about how effective it was for them if they felt like they were “coming down with something” (like a cold, flu, virus, infection, etc.). Greater skin elasticity greatly helped pregnant women avoid stretch marks and episiotomies. Today, we highly recommend its use together with our other Foundational Supplements to ensure optimal health and anti-aging effects.

THE PRO-C™ SUPER ANTIOXIDANT FORMULA

PRO-C™ super antioxidant formula is extremely synergistic, especially in so far as it increases the body’s ability to quench free radicals in its aqueous (i.e., water-based) compartments. Because antioxidants may become free radicals themselves after they have done their job, the body has developed an elaborate system for recovery of oxidized antioxidants.

 

Dr. Lester Packer was the primary researcher investigating the synergistic character of antioxidants. He made this statement in his interview with Dr. Richard Passwater after publication of Packer’s The Antioxidant Miracle (1999):

[The major theme of] The Antioxidant Miracle is that antioxidants work in a coordinated manner. They interact with one another, and this interaction, which we like to call the antioxidant network, is very important to the overall antioxidant defense that we possess. The key members of the antioxidant network are vitamin E and vitamin C, but there are other participants in this network. These are thiol antioxidants, antioxidants that contain sulfur groups in the body. Glutathione perhaps is the best known of these, but there are other sulfur-containing antioxidants that also are very important.”

Dr. Packer continues:

“This whole antioxidant network works like an orchestra depending on individuals who have, of course, different complements of antioxidants depending upon their nutritional regimens and the individuality of their own body metabolisms. The idea behind having a network of antioxidants is that if one antioxidant happens to be deficient the others can compensate and still keep the antioxidant defense system strong.”

The following diagram shows some of the relationships in the antioxidant network and how they support each other.

Lester Packer antioxidant network diagram Figure 1 – Dr. Packer’s Antioxidant Network

We see, for example, reduced glutathione (GSH) has the ability to reduce oxidized Vitamin C back to its unoxidized state. Vitamin C reduces oxidized Vitamin E back to its unoxidized state, and both reduces glutathione and spares it for other important functions, including detoxification and immune enhancement.

Many polyphenols (e.g., oligomeric proanthocyanidins (OPCs), anthocyanidins and catechins) found in red grape and green tea extracts spare Vitamin C and glutathione in the body, as well as operate as powerful antioxidants, anti-inflammatories, and connective tissue strengtheners.

grapes grape extract antioxidant

Grapes provide antioxidant nutrients such as polyphenols, OPCs, anthocyans, and resveratrol.

R-Lipoic Acid (see abstracts below) operates as an antioxidant both in its oxidized and reduced states, reduces the oxidized forms of both Vitamin E and Vitamin C, and and has been shown to enhance glutathione levels. Because several of these substances are able to protect Vitamin E contained in cell membranes, this combination also has a significant beneficial effect on the fat soluble antioxidant status of the body!

The nutrients in PRO-C have been carefully selected and balanced to provide optimal effects, especially as related to free radical protection, detoxification, immune system enhancement, connective tissue strengthening, and reduction of inflammation. PRO-C therefore provides outstanding nutritional support in a wide variety of conditions of poor health, as well as acts to support and maintain a state of health and well-being.

It the last several years the research results on Nrf2 activators have become well known and products developed that take advantage of these nutrients. For details see our blog article Natural Phytochemical Nrf2 Activators for Chemoprevention. Researchers have been studying specifically how enzyme-activating substances such as OPCs and anthocyans activate a transcription factor known as Nrf2 that causes the body to endogenously produce higher levels of a wide variety of protective enzymes including superoxide dismutase (SOD), catalase, and glutathione peroxidase.

Although we did not know about Nrf2 activators in 1997 when we formulated PRO-C, we have subsequently learned that four of the ingredients in the formula have powerful Nrf2 activity. These include grape seed extract, green tea extract, NAC, and r-lipoic acid. With this knowledge, we now understand that PRO-C provides both powerful external antioxidants (with extremely high ORAC5.0 values) that support redox cycles within the body, but also provides ingredients that allow the body to endogenously produce powerful protective enzymes for even greater free-radical protection and health.

PRO-C™ ANTIOXIDANT FORMULA INGREDIENTS

PRO-C contains buffered vitamin C (in the form of powdered calcium, magnesium, and zinc ascorbates), high-potency grape extract (from grape pulp, skins, and seeds), green tea extract (with>95% polyphenols and >45% EGCG), reduced glutathione, N-Acetyl-L-Cysteine (NAC), R-lipoic acid, coenzyme forms of vitamin B2 (R5P) and vitamin B6 (P5P), and selenium.

Below we will discuss each ingredient and show some of the research that confirms its effectiveness.

VITAMIN C

Vitamin C typically is called l-ascorbic acid or ascorbate and is an essential nutrient for humans and other animal species. The term “vitamin C” refers to a number of vitamins that have vitamin C activity in animals, including ascorbic acid and its salts (e.g., magnesium ascorbate, calcium ascorbate, sodium ascorbate, etc.), and some oxidized forms such as dehydroascorbate and semidehydroascorbate.

Vitamin C is known to perform many critical functions within the body involving detoxification, tissue building, immune enhancement, pain control, and controlling or killing pathogenic organisms. It is also known to be helpful for wound and bone healing, healthy skin and eyes, fighting infections, stress control, toxic exposure, and repairing damaged tissue of all types. For much more information on the many benefits of Vitamin C see our blog article Vitamin C – An Amazing Nutrient.

Below are two abstracts that show some of the beneficial effects of Vitamin C when used with other network antioxidants:

ABSTRACT 1:
Exhaustive physical exercise causes oxidation of glutathione status in blood: prevention by antioxidant administration.
Sastre J, Asensi M, Gasco E, Pallardo FV, Ferrero JA, Furukawa T, Vina J
In: Am J Physiol (1992 Nov) 263(5 Pt 2):R992-5

We have studied the effect of exhaustive concentric physical exercise on glutathione redox status and the possible relationship between blood glutathione oxidation and blood lactate and pyruvate levels. Levels of oxidized glutathione (GSSG) in blood increase after exhaustive concentric physical exercise in trained humans. GSSG levels were 72% higher immediately after exercise than at rest. They returned to normal values 1 h after exercise. Blood reduced glutathione (GSH) levels did not change significantly after the exercise. We have found a linear relationship between GSSG-to-GSH and lactate-to-pyruvate ratios in human blood before, during, and after exhaustive exercise. In rats, physical exercise also caused an increase in blood GSSG levels that were 200% higher after physical exercise than at rest. GSH levels did not change significantly. Thus, both in rats and humans, exhaustive physical exercise causes a change in glutathione redox status in blood. We have also found that antioxidant administration, i.e., oral vitamin C, N-acetyl-L- cysteine, or glutathione, is effective in preventing oxidation of the blood glutathione pool after physical exercise in rats.

ABSTRACT 2:
The effect of glutathione and vitamins A, C, and E on acute skin flap survival.

Hayden RE, Paniello RC, Yeung CS, Bello SL, Dawson SM
In: Laryngoscope (1987 Oct) 97(10):1176-9

Vitamins A, C, and E act as antioxidants and as free radical scavengers in biological systems. Glutathione is involved in several reactions in vitamin metabolism and also plays an important role in cell membrane protection against lipid peroxidation by free radicals. We sought to use these natural defense mechanisms against oxygen free radicals formed during reperfusion of ischemic skin flaps. An acute axial random skin flap model was utilized in the rat. Vitamins or glutathione were administered by oral gastric tube or intravenously in the perioperative period, and survival of the flap was measured at 1 week. Glutathione, beta-carotene, ascorbic acid and alpha-D- tocopherol showed mean flap survival of 84% to 89%, each of which was significantly improved over saline controls (67% p less than .0005). The mechanisms and biochemistry of these vitamins, and their interactions with other vitamins and with glutathione, are discussed, along with clinical implications of free radical scavenging and skin flap survival.

GRAPE EXTRACT

Grape extract (seeds, skin, pulp) contain highly bioavailable bioflavonoid complexes that in research studies have been shown to have powerful antioxidant capability. The Oligomeric Proanthocyanidins (OPCs) in grape seed extract are able to strengthen collagen fibers in aging or damaged connective tissue and can act as a preventative against connective tissue degradation.

Some research indicates that anthocyans, which are found in extracts of grape skin and stems (but not in grape seed extract), can reduce oxidized glutathione while at the same time become reduced themselves. In addition, extracts of grape skin and stems (but not those of grape seed extract) contain a material called trans-resveratrol that has been shown to have chemopreventive effects.

Below we have provided some of the abstracts that are included in our broad list of relevant abstracts for PRO-C.

ABSTRACT 3:
Protective effects of grape seed proanthocyanidins and selected antioxidants against TPA-induced hepatic and brain lipid peroxidation and DNA fragmentation, and peritoneal macrophage activation in mice.
Bagchi D, Garg A, Krohn RL, Bagchi M, Bagchi DJ, Balmoori J, Stohs SJ
In: Gen Pharmacol (1998 May) 30(5):771-6

1. The comparative protective abilities of a grape seed proanthocyanidin extract (GSPE) (25-100 mg/kg), vitamin C (100 mg/kg), vitamin E succinate (VES) (100 mg/kg) and beta-carotene (50 mg/kg) on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced lipid peroxidation and DNA fragmentation in the hepatic and brain tissues, as well as production of reactive oxygen species by peritoneal macrophages, were assessed. 2. Treatment of mice with GSPE (100 mg/kg), vitamin C, VES and beta-carotene decreased TPA-induced production of reactive oxygen species, as evidenced by decreases in the chemiluminescence response in peritoneal macrophages by approximately 70%, 18%, 47% and 16%, respectively, and cytochrome c reduction by approximately 65%, 15%, 37% and 19%, respectively, compared with controls. 3. GSPE, vitamin C, VES and beta-carotene decreased TPA-induced DNA fragmentation by approximately 47%, 10%, 30% and 11%, respectively, in the hepatic tissues, and 50%, 14%, 31% and 11%, respectively, in the brain tissues, at the doses that were used. Similar results were observed with respect to lipid peroxidation in hepatic mitochondria and microsomes and in brain homogenates. 4. GSPE exhibited a dose-dependent inhibition of TPA- induced lipid peroxidation and DNA fragmentation in liver and brain, as well as a dose-dependent inhibition of TPA-induced reactive oxygen species production in peritoneal macrophages. 5. GSPE and other antioxidants provided significant protection against TPA-induced oxidative damage, with GSPE providing better protection than did other antioxidants at the doses that were employed.

ABSTRACT 4:
Clinical and capillaroscopic evaluation of chronic uncomplicated venous insufficiency with procyanidins extracted from vitis vinifera
Costantini A, De Bernardi T, Gotti A
In: Minerva Cardioangiol (1999 Jan-Feb) 47(1-2):39-46

BACKGROUND: The pharmacological treatment of non-complicated chronic venous insufficiency is a current and well-debated topic. The introduction of new products with action on the venous system, improved knowledge on the physiopathology of venous insufficiency and the possibility provided by new analytical instruments, have given new impulse to the consolidation of the clinical value of phlebotonics in this indication. METHODS: In light of this, 24 patients with non-complicated chronic venous insufficiency were treated with oral administration of Oligomeric Proanthocyanidins (Pycnogenols-OPC) 100 mg/day. To evaluate the therapeutic efficacy of the treatment, an instrumental evaluation by optical probe capillaroscope was employed in addition to the traditional subjective clinical parameters: swelling, itching, heaviness and pain. The videocapillaroscope examination was performed at the lower third of the leg and the first toe. Edema in the capillaroscopic field, the number of observable capillaries and the capillary dilatation were the parameter chosen to evaluate the efficacy of treatment. All patients completed the study with no reports of adverse events during the period of observation. RESULTS: The results obtained show a positive clinical response (improved or absent symptoms) in over 80% of patients, with significant improvement of symptoms already evident after the first 10 days of treatment. The mechanism of action of the OPCs explains the rapid reduction of the swelling of the lower limbs and correlated with this are the other evaluable symptoms: heaviness and itching. Particularly striking results were observed for itching and pain which completely disappeared during the course of therapy in 80% and 53% of the patients respectively. Noteworthy is the good correlation between the clinical and instrumental data, with improvement in a total of 70% of patients. CONCLUSIONS: The results obtained in the course of this clinical experience, with evident improvement already during the first weeks of treatment, the absence of adverse events added to the benefit of a once-a-day administration, justify the use of OPC in the treatment of non-complicated chronic venous insufficiency.

ABSTRACT 5:
Polymeric procyanidin fraction from defatted grape seeds protects HepG2 cells against oxidative stress by inducing phase II enzymes via Nrf2 activation.
Younghwa Kim, Youngmin Choi, Hyeonmi Ham, Heon-Sang Jeong, Junsoo Lee
Kim, Y., Choi, Y., Ham, H. et al. Food Sci Biotechnol (2013) 22: 485. https://doi.org/10.1007/s10068-013-0105-x

Nuclear factor erythroid 2-related factor 2 (Nrf2) is an important transcription factor that regulates antioxidant response element (ARE)-driven phase II detoxification enzymes. In this study, induction of phase II enzymes via Nrf2/ARE activation in the cytoprotective effect of crude polyphenol extract (CPE), oligomeric procyanidin fraction (OPF), and polymeric procyanidin fraction (PPF) from defatted grape seeds in HepG2 cells was evaluated. Among these treatments, the treatment with PPF significantly increased Nrf2 protein expression in the nuclear fraction. Treating the samples increased heme oxygenase-1 (HO-1) and NAD(P)H:quinone oxidoreductase 1 (NQO1) protein expression in a dose-dependent manner, and PPF significantly increased the levels of phase II enzymes. Cellular generation of reactive oxygen species (ROS) were effectively reduced by PPF. These results suggest that pretreatment with PPF shows a cytoprotective effect by inhibiting ROS production and inducing HO-1 and NQO1 expression via Nrf2 activation in HepG2 cells.

GREEN TEA EXTRACT

Green tea extract is obtained from the unfermented leaves of Camellia sinensis for which numerous biological activities have been reported including: antimutagenic, antibacterial, hypocholesterolemic, antioxidant, and protective against tumorigenesis. Below we have selected a few of the many abstracts we have on file showing the benefit of green tea extract.

Green tea antioxidant polyphenols catechins

Green tea leaves are high in antioxidant polyphenols and catechins.

ABSTRACT 6:
Enhancement of antioxidant and phase II enzymes by oral feeding of green tea polyphenols in drinking water to SKH-1 hairless mice: possible role in cancer chemoprevention.
Khan SG, Katiyar SK, Agarwal R, Mukhtar H
In: Cancer Res (1992 Jul 15) 52(14):4050-2

Following the oral feeding of a polyphenolic fraction isolated from green tea (GTP) in drinking water, an increase in the activities of antioxidant and phase II enzymes in skin, small bowel, liver, and lung of female SKH-1 hairless mice was observed. GTP feeding (0.2%, w/v) to mice for 30 days significantly increased the activities of glutathione peroxidase, catalase, and quinone reductase in small bowel, liver, and lungs, and glutathione S-transferase in small bowel and liver. GTP feeding to mice also resulted in considerable enhancement of glutathione reductase activity in liver. In general, the increase in antioxidant and phase II enzyme activities was more pronounced in lung and small bowel as compared to liver and skin. The significance of these results can be implicated in relation to the cancer chemopreventive effects of GTP against the induction of tumors in various target organs.

ABSTRACT 7:
INHIBITORY EFFECT OF SIX GREEN TEA CATECHINS AND CAFFEINE ON THE GROWTH OF FOUR SELECTED HUMAN TUMOR CELL LINES.
In: Anticancer Drugs (1996 Jun) 7(4):461-8
Institutional address: Department of Pharmacology and Toxicology College of Pharmacy University of Arizona Tucson 85721 USA.

Green tea is an aqueous infusion of dried unfermented leaves of Camellia sinensis (family Theaceae) from which numerous biological activities have been reported including antimutagenic, antibacterial, hypocholesterolemic, antioxidant, antitumor and cancer preventive activities. From the aqueous-alcoholic extract of green tea leaves, six compounds (+)-gallocatechin (GC), (-)-epicatechin (EC), (-)- epigallocatechin (EGC), (-)-epicatechin gallate (ECG), (-)- epigallocatechin gallate (EGCG) and caffeine, were isolated and purified. Together with (+)-catechin, these compounds were tested against each of four human tumor cells lines (MCF-7 breast carcinoma, HT-29 colon carcinoma, A-427 lung carcinoma and UACC-375 melanoma). The three most potent green tea components against all four tumor cell lines were EGCG, GC and EGC. EGCG was the most potent of the seven green tea components against three out of the four cell lines (i.e. MCF-7 breast cancer, HT-29 colon cancer and UACC-375 melanoma). On the basis of these extensive in vitro studies, it would be of considerable interest to evaluate all three of these components in comparative preclinical in vivo animal tumor model systems before final decisions are made concerning which of these potential chemopreventive drugs should be taken into broad clinical trials.

GLUTATHIONE AND N-ACETYL-L-CYSTEINE (NAC)

Glutathione and NAC (a major precursor of glutathione) both provide important protection against toxins and free radicals, and can strengthen the immune system. Glutathione is considered to be one of the most important protective substances in the human body with almost 60% of liver detoxification accounted for by this key substance. In addition, glutathione is one of the most potent anti-viral substances known.

Some research has indicated that glutathione may not be able to enter easily into certain types of cells, but NAC is able to enter these cells and be converted into glutathione once inside the cell. Thus, the combination of glutathione and NAC appear to be more potent than either alone.

Below we provide some of the key abstracts we have on file regarding NAC and glutathione.

ABSTRACT 8
GSH rescue by N-acetylcysteine.
Ruffmann R Wendel A
In: Klin Wochenschr (1991 Nov 15) 69(18):857-62

Reduced glutathione (GSH) is the main intracellular low molecular weight thiol. GSH acts as a nucleophilic scavenger and as an enzyme-catalyzed antioxidant in the event of electrophilic/oxidative tissue injury. Therefore, GSH has a major role as a protector of biological structures and functions. GSH depletion has been recognized as a hazardous condition during paracetamol intoxication. Conversely, GSH rescue, meaning recovery of the protective potential of GSH by early administration of N-acetylcysteine (NAC), has been found to be life-saving. Lack of GSH and electrophilic/oxidative injury have been identified among the causes of the adult respiratory distress syndrome (ARDS), idiopathic pulmonary fibrosis (IPF), and the acquired immunodeficiency syndrome (AIDS). Experimental and early clinical data (in ARDS) point to the role of NAC in the treatment of these conditions. Recently, orally given NAC has been shown to enhance the levels of GSH in the liver, in plasma, and notably in the bronchoalveolar lavage fluid. Rescue of GSH through NAC needs to be appreciated as an independent treatment modality for an array of different disease, all of which have one feature in common: pathogenetically relevant loss of GSH.

ABSTRACT 9
Cysteine and glutathione concentrations in plasma and bronchoalveolar lavage fluid after treatment with N-acetylcysteine.
Bridgeman MM Marsden M MacNee W Flenley DC Ryle AP
In: Thorax (1991 Jan) 46(1):39-42

N-acetylcysteine (600 mg/day) was given to patients by mouth for five days before bronchoscopy and bronchoalveolar lavage to determine whether N-acetylcysteine could increase the concentrations of the antioxidant reduced glutathione in plasma and bronchoalveolar lavage fluid. Bronchoalveolar lavage was performed 1-3 hours (group 2, n = 9) and 16-20 hours (group 3, n = 10) after the last dose of N-acetylcysteine and the values were compared with those in a control group receiving no N-acetylcysteine (group 1, n = 8). N-Acetylcysteine was not detected in plasma or lavage fluid. Plasma concentrations of cysteine, the main metabolite of N-acetylcysteine and a precursor of reduced glutathione, were greater in the groups receiving treatment (groups 2 and 3) than in group 1. Cysteine concentrations in lavage fluid were similar in the three groups. Concentrations of reduced glutathione were greater in both plasma and lavage fluid in group 2 than in group 1. These data suggest that N-acetylcysteine given by mouth is rapidly deacetylated to cysteine, with resulting increases in the concentrations of cysteine in plasma and of reduced glutathione in plasma and the airways, which thus temporarily increase the antioxidant capacity of the lung.

R-LIPOIC ACID / ALPHA-LIPOIC ACID

R-Lipoic Acid is normally made at low levels in the human body, where it functions primarily as an important metabolic nutrient in the conversion of pyruvic acid into acetyl coenzyme A. As such, it plays a crucial role in the metabolism of both fats and carbohydrates into energy. In addition, r-lipoic acid functions as an extremely powerful antioxidant capable of trapping many different types of free radicals in the body.

Because it is both water and fat soluble, lipoic acid is able to operate in a broader range of body tissues than most other antioxidants. Its small size allows lipoic acid to enter areas of the body not easily accessible to many other substances; this allows lipoic acid, for example, to enter the cell nucleus and prevent free-radical damage to DNA.

Because it is such a powerful antioxidant and can easily function as such in both a reduced and oxidized state, lipoic acid is able to protect other important antioxidants such as glutathione, Vitamin E, and Vitamin C. R-lipoic acid is also able to chelate heavy metals such as lead, cadmium, mercury, free iron, and free copper out of the body.

Below we provide relevant scientific abstracts from our database regarding R-Lipoic acid.

ABSTRACT 10:
Alpha-Lipoic acid as a biological antioxidant.
Packer L Witt EH Tritschler HJ
In: Free Radic Biol Med (1995 Aug) 19(2):227-50

alpha-Lipoic acid, which plays an essential role in mitochondrial dehydrogenase reactions, has recently gained considerable attention as an antioxidant. Lipoate, or its reduced form, dihydrolipoate, reacts with reactive oxygen species such as superoxide radicals, hydroxyl radicals, hypochlorous acid, peroxyl radicals, and singlet oxygen. It also protects membranes by interacting with vitamin C and glutathione, which may in turn recycle vitamin E. In addition to its antioxidant activities, dihydrolipoate may exert prooxidant actions through reduction of iron. alpha-Lipoic acid administration has been shown to be beneficial in a number of oxidative stress models such as ischemia-reperfusion injury, diabetes (both alpha-lipoic acid and dihydrolipoic acid exhibit hydrophobic binding to proteins such as albumin, which can prevent glycation reactions), cataract formation, HIV activation, neurodegeneration, and radiation injury. Furthermore, lipoate can function as a redox regulator of proteins such as myoglobin, prolactin, thioredoxin and NF-kappa B transcription factor. We review the properties of lipoate in terms of (1) reactions with reactive oxygen species; (2) interactions with other antioxidants; (3) beneficial effects in oxidative stress models or clinical conditions.

ABSTRACT 11:
Regeneration of glutathione by α-lipoic acid via Nrf2/ARE signaling pathway alleviates cadmium-induced HepG2 cell toxicity.
Zhang J, Zhou X, Wu W, Wang J, Xie H, Wu Z.
In: Environ Toxicol Pharmacol. 2017 Apr;51:30-37. doi: 10.1016/j.etap.2017.02.022. Epub 2017 Feb 27.

Alpha-lipoic acid (α-LA) is an important antioxidant that is capable of regenerating other antioxidants, such as glutathione (GSH). However, the underlying molecular mechanism by which α-LA regenerates GSH remains poorly understood. The current study aimed to investigate whether α-LA regenerates GSH by activation of Nrf2 to alleviate cadmium-induced cytotoxicity in HepG2 cells. In the present study, we found that cadmium induced cell death by depletion of GSH through inactivation of Nrf2. Addition of α-LA to cadmium-treated cells reactivated Nrf2 and regenerated GSH through elevating the Nrf2-downstream genes γ-glutamate-cysteine ligase (γ-GCL) and GR, both of which are key enzymes for GSH synthesis. However, blocking Nrf2 with brusatol in the cells co-treated with α-LA and cadmium reduced the mRNA and the protein levels of γ-GCL and GR, thus suppressed GSH regeneration by α-LA. Our results indicated that α-LA activated Nrf2 signaling pathway, which upregulated the transcription of the enzymes for GSH synthesis and therefore GSH contents to alleviate cadmium-induced cytotoxicity in HepG2 cells.

SELENIUM

Selenium has been shown by clinical research to be a key mineral in the body’s defenses against free radicals and has been shown to be a major factor in reducing the symptoms of HIV infections and in the prevention of tumors. Selenium is used in conjunction with glutathione to form the powerful enzyme glutathione peroxidase that is responsible for detoxification of peroxides formed during the process of aerobic metabolism in humans and other animals.

ABSTRACT 12
Serum selenium concentrations in rheumatoid arthritis.
In: Ann Rheum Dis (1991 Jun) 50(6):376-8

O’Dell JR, Lemley-Gillespie S, Palmer WR, Weaver AL, Moore GF, Klassen LW

Selenium is a trace element and an essential part of the enzyme glutathione peroxidase, which protects cells from oxidative damage. Selenium has been shown to have antiproliferative, anti-inflammatory, antiviral, and immune altering effects. Serum selenium concentrations in 101 patients with seropositive rheumatoid arthritis were found to be significantly lower than those in 29 normal, healthy controls (mean (SD) 148 (42) v 160 (25) micrograms/l) and also lower than those in eight patients with fibrositis (148 (42) v 166 (25) micrograms/l). It is speculated that serum selenium concentrations may modulate the effect of viral or other infections in subjects with the appropriate genetic background and in this way enhance the development or progression of rheumatoid arthritis.

ABSTRACT 13
Studies on selenium in top athletes.
Dragan I, Ploesteanu E, Cristea E, Mohora M, Dinu V, Troescu VS
In: Physiologie (1988 Oct-Dec) 25(4):187-90

The authors performed a controlled trial in 18 top athletes (9 weight lifters and 9 rowers, girls) in order to make evident some chronic and acute effects (antioxidant) of selenium. Nonprotein–SH (essential glutathione), lipid peroxides (MDA-malondialdehyde), glucose-6-phosphate dehydrogenases (G-6-PDH) and fructose-1,6- diphosphate aldolase in serum, have been recorded initially on basal conditions, after 3 weeks of treatment (100 micrograms/day selenium or placebo) and again after 3 weeks of treatment, also on basal conditions, when crossing over the groups (between a free interval of 10 days). In another trial we registered these parameters on basal conditions and after two hours of hard training accompanied by a per oral administration of 150 micrograms selenium (respectively placebo). The results show significant changes under selenium treatment of the peroxides, G-6-PDH and light changes, not significant of the nonprotein–SH, changes which could suggest an antioxidant effect of this element.

VITAMINS B2 and B6 IN COENZYME FORMS

Vitamin B2 as coenzyme riboflavin-5-phosphate is a key vitamin that supports the regeneration of glutathione (via glutathione reductase). Vitamin B6 as coenzyme pyridoxal-5-phosphate is a key vitamin that supports the ability of glutathione to combine with toxic substances (via glutathione transferase) in the process of eliminating them from the body. They are especially effective in their coenzyme forms which allows them to be directly utilized by the body starting in the intestinal tract.

MAGNESIUM, CALCIUM, AND ZINC

Magnesium, zinc, and calcium synergistically work with (and enhance the effects of) the other ingredients in PRO-C. Minerals are especially needed as active components of enzymes that drive metabolic activity. For example, magnesium is required in the functioning of more than 325 types of enzymes.

PRO-C™ SUPER ANTIOXIDANT FORMULA BENEFITS

HIGHLY EFFECTIVE VITAMIN C FORMULA PLUS ANTIOXIDANTS. A complete vitamin C formula, a powerful antioxidant Formula, and Nrf2 activator combined in a single advanced supplement!

POWERFUL, SYNERGISTIC FREE-RADICAL QUENCHING FORMULA. PRO-C™ components work together to quench free radicals in your body. Vitamin C enables grape seed extract to function more effectively, and conversely grape seed extract potentiates vitamin C. Green tea extract boosts ORAC (Oxygen Radical Absorbance Capacity) value.

PROVIDES SIGNIFICANT AMOUNTS OF POWERFUL NRF2 ACTIVATORS (from Grape Extract, Green Tea Extract, NAC, and R-Lipoic Acid) that stimulate the production of the body’s own protective antioxidants including superoxide dismutase, catalase, glutathione peroxidase, and heme oxygenase.

SUPERIOR, BUFFERED (NON-ACIDIC) FORM OF VITAMIN C. Mineral Ascorbates never acidify your body, keeping you pH balanced. Staying alkaline is an important element in maintaining a healthy body.

RAPID ASSIMILATION. Capsule form ensures rapid uptake and assimilation in the body. You may also empty capsule contents into water, food, or directly Into mouth, if desired. Good, mildly tart taste!

COMPOSITION OF PRO-C™ SUPER ANTIOXIDANT FORMULA

One (1) vegetarian capsule of PRO-C provides the following percentages of the Daily Value:

NUTRIENT AMOUNT % Daily Value
Vitamin C (from mineral ascorbates) 500 mg 833%
BioVin® Grape Extract 30 mg *
Green Tea Extract 30 mg *
Calcium (from calcium ascorbate) 23 mg 2.3%
Magnesium (from magnesium ascorbate) 23 mg 5.7%
L-Glutathione (reduced) 20 mg *
N-Acetyl-L-Cysteine (NAC) 15 mg *
R-Lipoic Acid 5 mg *
Zinc (from zinc ascorbate) 2 mg 13%
Vitamin B2 (from riboflavin-5′-phosphate) 1 mg 118%
Vitamin B6 (from pyridoxal-5′-phosphate) 1 mg 50%
Selenium (from l-selenomethionine) 10 mcg *

* No established Daily Value

DIRECTIONS: As a dietary supplement take 1–3 capsules or more daily in divided doses (i.e., spread out over the day), or as recommended by a health care professional. It initially may be useful to take up to 6 capsules per day in divided doses for one week. The contents of the capsule may be emptied into juice or food, as needed.

INGREDIENTS: PRO-C™ SUPER ANTIOXIDANT FORMULA contains only the highest-quality USP grade magnesium ascorbate, USP grade calcium ascorbate, BioVin® grape extract (greater than 75% polyphenols, 55% OPC, greater than 3.5% anthocyanidins from grape pulp, skins, and seeds, and a small amount of trans resveratrol), green tea extract (95% min. polyphenols and 45% min. EGCG), l-glutathione (reduced), USP grade n-acetyl-l-cysteine, USP grade zinc ascorbate, r-(+)-lipoic acid, riboflavin-5′-phosphate, pyridoxal-5′-phosphate, l-selenomethionine, the smallest amounts of microcrystalline cellulose and silica in a vegetarian capsule.

PRO-C™ does not contain wheat, rye, oats, corn antigen, barley, gluten, soy, egg, dairy, yeast, sugar, sulfates, phosphates (other than coenzyme forms), fats, chlorides, GMOs, wax, preservatives, colorings, or artificial flavorings.

Click here to order PRO-C™.

SOURCES & RESOURCES

BOOKS

The Antioxidant Miracle. Lester Packer, PhD, and Carol Coleman. New York: John Wiley and Sons, 1999.

How to Live Longer and Feel Better. Dr. Linus Pauling. Corvallis, OR: Oregon State University Press, 2006.

ARTICLES

Review of Scientific Research on Oligomeric Proanthocyanidins (OPC)” (rev. 2017) by Hank Liers, PhD

“Vitamin C – An Amazing Nutrient” by Hank Liers, PhD

PRO-C™ and Ultimate Protector™ – Comparison by Hank Liers, PhD

“Antioxidant Cocktail Update: Part 1: The Take Home Message is to Use Antioxidant Supplements”
(An interview of Dr. Lester Packer by Richard A. Passwater, PhD, Whole Foods Magazine 1999)

ABSTRACTS

PRO-C™ / Vitamin C Abstracts

Catechin Abstracts

N-Acetyl-L-Cysteine (NAC) Abstracts

Lipoic Acid Abstracts

WEBSITES

Orthomolecular.org
(Therapeutic Nutrition Based Upon Biochemical Individuality)

PRODUCTS

PRO-C™Super Antioxidant Formula

Ultimate Protector™Nrf2 Activator Formula

OPC-C™

HPDI Vitamin C Products

0

INTESTINAL REJUVENATION FORMULA – VIDEO

Fred Liers PhD intestinal rejuvenation formula IRFAmong the most essential aspects of detoxification are the sequestering of toxins and waste from the gastrointestinal tract and its proper elimination. HPDI’s Intestinal Rejuvenation Formula meets the need for an effective intestinal sweep to cleanse the entire GI tract for improved gut health and function.

Intestinal Rejuvenation Formula (or “IRF”) is our unique product that 1) latches onto toxins, old waste, and deposits in the digestive tract, 2) binds, pulls, and absorbs these materials, 3) sweeps them from the entire intestinal tract, while 4) naturally and gently facilitating elimination.

That’s just the start! You have to experience this formula yourself to appreciate its benefits most.

Intestinal Rejuvenation Formula works by coating and adhering to the lining of the intestines. This unique action allows it to absorb fecal plaques and other debris, soften unhealthy deposits, and sweep them away for elimination in the stool. The IRF formula thereby neutralizes and removes hundreds of toxins, including heavy metals like mercury and lead. It draws out many times its weight in material encrusted or trapped in the intestinal lining. It also provides nutrients not only known to nourish the GI tract, but also that promote normal elimination functions.

The easiest way to start using Intestinal Rejuvenation Formula is to put one teaspoon in eight ounces of water. Stir or shake, then drink immediately. You can then add some additional water to the container, stir and drink. You can start at 1/2 teaspoon (or less) if one teaspoon seems like too much. You can gradually work you way up to one tablespoon in 16 ounces of water or juice.

Note: It is important to consume the formula immediately after mixing with water to avoid the formula thickening which makes it difficult to drink. It is also important to consume sufficient water so it can swell and more easily pass through the digestive tract.

Intestinal Rejuvenation Formula

Intestinal Rejuvenation Formula is formulated to cleanse, detoxify, purify, and heal. You and your clients will love IRF!

HOW INTESTINAL REJUVENTION FORMULA CAN HELP

Intestinal Rejuvenation Formula relieves symptoms of constipation, including gas, bloating, cramps, indigestion, and nausea caused by excessive waste in the bowel. It also soothes the intestinal lining and colon wall, and promotes a well-functioning colon. This means it can contribute to greater health not only through removal of toxins and intestinal blockages, but also by allowing greater absorption of nutrients from food (i.e., after the intestines are cleansed). It also can contribute to achieving normal weight by promoting elimination of old fecal matter (e.g., post-putrefactive deposits), and by helping to establish and maintain normal bowel function.

Intestinal Rejuvenation Formula acts as a wonderful soothing agent for the mucous membrane linings of the entire intestinal tract, especially the colon. This makes it an important formula for individuals experiencing irritable bowel syndrome, spastic colon, colitis, Crohn’s disease, diverticulitis, or any digestive tract condition causing hot, burning, irritated, or bleeding bowels and/or diarrhea. This unique healing formula is also an excellent remedy for food poisoning, because it can absorb harmful bacteria and toxins.

Intestinal Rejuvenation Formula also can be applied externally as a poultice to insect bites and stings (e.g., bee, ant, scorpion), snake bites, etc. The drawing power of the formula acts to pull toxins directly from wounds. Poultices are highly effective for pulling venoms, and work especially well when combined with echinacea tincture (used orally and topically) and homeopathic remedies (e.g., apis mellifera, ledum palustre, arnica montana). This application makes the formula truly unique. See directions (below) for external applications.

WHAT INTESTINAL REJUVENATION FORMULA CONTAINS

The ingredients in Intestinal Rejuvenation Formula make it one of the most effective products for complete cleansing of the gastrointestinal tract available today. IRF includes not only includes ingredients for binding and removing toxins and waste, but also for healing the entire GI tract.

INGREDIENTS: One teaspoon (3.23 gram) provides the following nutrients:

Psyllium Husk Powder (organic) – 1,000 mg
Apple Pectin – 400 mg
Bentonite Clay (wildcrafted) – 400 mg
Cold-Milled Flax Seed Powder (organic) – 400 mg
Marshmallow Root Powder (organic) – 200 mg
Slippery Elm Bark Powder (organic) – 200 mg
Activated Willow Charcoal (wildcrafted) – 100 mg
Spirulina Pacifica – 100 mg
Inulin / Fructooligosaccharides (from Chicory Root) – 100 mg
Ginger Root Powder (organic) – 100 mg
Natural Lemon Flavor – 100 mg
Vitamin C (from magnesium ascorbate) – 60 mg
Malic Acid – 50 mg
Grape Extract (pulp, skin, & seeds) – 40 mg
Licorice Root Powder (organic) – 40 mg
Stevia Leaf Extract (97% Rebaudioside A) – 13 mg
Magnesium (from magnesium ascorbate) – 4.5 mg
Chlorella Growth Factor (CGF) – 4 mg

Intestinal Rejuvenation Formula
NUTRITIONAL CONSIDERATIONS AND APPLICATIONS

The nutrients contained in Intestinal Rejuvenation Formula are all known to provide unique therapeutic benefits and healing properties. Consequently, the formula is carefully designed so the ingredients work together synergistically to leverage and maximize the capacities of each one. This results in a formula that is superior in action and that can far more effectively support health and healing in the intestinal tract than single ingredients or shotgun approaches (that often result in reduced effectiveness through the use of fillers, imbalanced formulation, or less than the highest quality ingredients).

Intestinal Rejuvenation Formula is a superior formulation representing a higher level of design expertise. This unique formula can offer significant benefits and results for individuals who wish to improve, regenerate, rejuvenate, heal, and sustain excellent gastrointestinal health.

PSYLLIUM HUSK POWDER (organic)

Psyllium seed husks are soluble in water, expanding and becoming mucilaginous when moistened. Psyllium seed husks are indigestible in human beings and are used as a source of dietary fiber. They are used to relieve constipation, irritable bowel syndrome, diverticular disease, and diarrhea. They are also used as a regular dietary supplement to improve and maintain regular gastrointestinal (GI) transit. The inert bulk of the husks helps to provide a constant volume of solid material regardless of other aspects of the diet or any disease condition of the gut. Recent research also shows psyllium seed husks to be promising in lowering cholesterol and controlling diabetes.

APPLE PECTIN

As a dietary fiber, apple pectin is helpful in maintaining good digestive health. Pectin forms a colloidal solution in water and gels when cool. An indigestible, soluble fiber, apple pectin is a general intestinal regulator used in many healing preparations, especially as an anti-diarrheal agent. Researchers at the University of California, Davis (UCD), found that apple pectin acts as an antioxidant against the damaging portion of cholesterol in the blood stream.

It has been established that a diet rich in apple pectin may help protect against certain diseases. Research in Japan shows that apple pectin can act as a chemopreventive agent. Apple pectin helps maintain intestinal balance by cleansing the intestinal tract with its soluble and insoluble fibers. Apple pectin tends to increase acidity in the large intestines and is advocated for those suffering from ulcer or colitis and for regulating blood pressure. Pectin is also effective in causing regressions in and preventing gallstones. There is also evidence that the regular use of apple pectin may lessen the severity of diabetes.

Apple pectin is known to draw radiation from the body. Russian doctors have found apple pectin to be among the most effective means for protecting against radiation when consuming contaminated foods is unavoidable. Pectin, along with vitamins and minerals, eliminates radionuclides ingested from foods. This is especially relevant given recent meltdowns and radiation releases from the nuclear complex in Fukushima, Japan. Radiation from this catastrophe has contaminated (and continues contaminating) food crops across the entire northern hemisphere (and beyond), especially crops grown in North America.

BENTONITE CLAY

Bentonite clay has a large and varied mineral content, including over 50 minerals. Seen under a high powered microscope, bentonite is composed of extremely minute rectangular particles. The wide surfaces are negatively charged and the edges are positively charged. Therefore, its adsorptive power is many thousand times more negative than positive. It has a negative electrical attraction for positively charged particles. In the human body, various toxic poisons are positively charged. The very minuteness of the particles give it a large surface area (about 1,000 square meters per gram) relative to its volume, thereby enabling it to pick up many times its own weight (as high as 40 times) in positively charged particles.

When bentonite clay absorbs water and swells, it stretches open like a highly porous sponge. Toxins (including pathogenic viruses, herbicides, and pesticides) are drawn into these spaces and bound through electrical attraction. The bentonite is eventually eliminated from the body with the toxins bound to its multiple surfaces. Diarrhea can be remedied through the use of bentonite clay because of its capacity to bind stools. Bentonite clay can act immediately to bind irritants in the gastrointestinal tract.

COLD-MILLED FLAX SEEDS (organically grown)

Flax Seeds (Linum usitatissimum L.) contain essential fatty acids (an excellent vegetarian source of omega-3 alpha-linolenic acid), protein, soluble fiber, insoluble fiber, antioxidant lignans, minerals, and vitamins. Lignans are a phytoestrogens considered to be antioxidants. Flax seeds contain among the highest levels of lignans among all plant foods.

The unique properties of Heartland’s RCM™ Flax (Real Cold Milled) organic flaxseed provides enormous advantages over whole flax seeds, ground flax powders, and other milled flax seed products. In particular, cold-milled flax seeds offer readily assimilable omega-3 and omega-6 fatty acids because of special no-heat processing that protects these delicate oils and makes them available for uptake into the body.

RCM™ Flax cold-milled flaxseed is processed using a unique, proprietary method that preserves the delicate oils and allows for optimal uptake of the oils and other nutrients (e.g., soluble fiber) into the body. That is, flax seeds must be milled into a flour or meal to obtain maximum benefits from its oils and dietary fiber. However, typical methods of grinding or pounding flaxseeds separate the oil from the seeds (and heat the oils), thereby causing the oils to oxidize and become rancid. In contrast, cold milling is a unique process that does not involve heating delicate oils and keeps them protected within finely milled pieces of seed. Thus, cold-milled flax seed is not significantly oxidized and remains fresh for an extended period of time. Conversely, when flax seeds are harshly ground or crushed, the oils do not remain fresh because there is no inherent protection from oxidation. Cold milling allows the seed to retain and protect its oils because the process does not release the oils from the seeds.

RCM™ Flax offers a non-refrigerated shelf life of greater than 24 months. A study conducted at North Dakota State University confirms that peroxide levels of RCM™ Flax remain exceptionally low for an extended periods. While this flaxseed retains its freshness for an extended period, when refrigerated (or consumed within several months), it provides amazingly high levels of freshness.

The organic cold-milled flax seeds in Intestinal Rejuvenation Formula contain oil amounts varying between 38–45%, with the oil offering a high percentage (47–53%) of the omega-3 alpha-linolenic acid (ALA) and 15–18% omega-6 linoleic acid. Alpha-linolenic acid (ALA) is an essential fatty acid acting in the human body as a substratum for the transformation into EPA and DHA through the action of desaturation and elongation enzymes. The seeds also contain some omega-6 essential fatty acids and exhibit a favorable omega-3 to omega-6 ratio of 3:1. Modern diets contain too few omega-3 fatty acids.

Cold-milled flax seeds possess 15–30% protein (typically 20%) and the amino acids of flax protein have no limiting factors in the adult diet (i.e., they are a complete protein source having all of the essential amino acids in an appropriate balance). Flax seeds are also a source of magnesium, calcium, potassium, phosphorus, zinc, and copper. They also have demonstrated antioxidant activity. The most important antioxidants they provide are phytoestrogens known as lignans. Because cold milling flax seeds significantly reduces oxidation, this exceptional flax seed has great potential within the food industry when compared to other alpha-linolenic acid sources, such as typical ground flaxseed powders, which can exhibit rapid decomposition due to a lack of antioxidant protection from oxidation.

The human body easily digests flax seeds. The seed’s outer layer is rich in mucilloid soluble fiber (flax seed possesses 10-15% soluble fiber) and absorbs at least 4 times its weight in water. When mixed with water or stomach juices, the seeds form a gel that creates a physical barrier between the carbohydrates and the digestive enzymes that break them down. The carbohydrates thereby are digested and converted into glucose (blood sugar) at a slow, uniform rate. There is no insulin surge or spike needed to lower the blood sugar level. The water-retaining capacity of the gel also maintains bodily hydration (i.e., helping level out water intake) and electrolyte balance.

MARSHMALLOW ROOT POWDER (organic)

Considered the king of mucilaginous (gel-like) slippery plants, marshmallow offers a unique composition of about 37% starch, 11% mucilage, and 11% pectin (including flavonoids and phenolic acids). When it reaches the colon, marshmallow gel will soften hardened fecal plaques and help to remove them from colon walls. It also acts as a soothing coating and internal moisturizer for the entire digestive tract. Like chia seeds, it neutralizes irritants often found in the intestinal system, and thereby greatly relieves irritation to the mucous membrane lining of the digestive tract.

SLIPPERY ELM BARK POWDER (organic)

The health benefits of slippery elm are rooted mainly in its soothing properties. This mucilaginous herb is effective when used internally for coating and soothing mucous membranes while also absorbing toxins that can cause intestinal imbalances. Slippery elm is an effective remedy for duodenal ulcers, gastritis, diarrhea, colitis, irritable bowel syndrome, hemorrhoids, and heartburn. The benefits of slippery elm also extend to being a simple food. As part of a normal diet, the inner bark of slippery elm can be ground and eaten as porridge. This porridge is extremely nutritious and high in antioxidants having a consistency and taste similar to oatmeal. It is also a wholesome and sustaining food for infants and invalids.

ACTIVATED WILLOW CHARCOAL (wildcrafted)

Activated charcoal is charcoal that has been treated with oxygen to open up millions of tiny pores between the carbon atoms. The use of special manufacturing techniques results in highly porous charcoals that have surface areas of 300–2,000 square meters per gram. Charcoal works to trap toxins through “adsorption.” When a material adsorbs something, it attaches to it via chemical attraction. The huge surface area of activated charcoal gives it countless bonding sites for adsorbing toxins.

When certain chemicals pass next to the carbon surface, they attach to the surface and become trapped. Activated charcoal is excellent for trapping carbon-based substances (i.e., organic chemicals), as well as other chemicals such as chlorine. It is known to trap over 20,000 organic chemicals. Many chemicals are not attracted to carbon (sodium, nitrates, etc.) so they pass through charcoal. Because charcoal is not “digested” like food, it may remain inside the GI tract for a time, thereby continuing to actively remove toxins via the bowel.

SPIRULINA PACIFICA

Research has shown that spirulina promotes digestion and bowel function. It suppresses bad bacteria (including E. coli and Candida albicans yeast) and stimulates beneficial flora, including lactobacillus and bifidobacteria. Healthy intestinal flora (i.e., “good” bacteria) are a foundation for good health. They increase absorption of nutrients from foods and help protect against infection. In Japan, researchers found that spirulina significantly reduces kidney toxicity caused by mercury and three pharmaceutical drugs. This suggests benefits for humans suffering heavy metal poisoning. Additional research found that rats consuming spirulina or chlorella algae eliminated seven times the amount of dioxin (a highly toxic chemical) when compared to a control diet.

INULIN / FRUCTOOLIGOSACCHARIDES (from Chicory Root)

Like other types of dietary fiber, inulin also has the benefits of enhancing digestive and intestinal functions, reducing cholesterol, and preventing disease. In addition, inulin has one other major health benefit: it is a prebiotic that feeds the healthy microflora that boost your immunity. Not only does inulin actively promote the growth of existing strains of probiotics in your colon, but it also encourages implantation, survival, and growth of freshly consumed probiotics. By boosting the survival and growth of beneficial probiotics in the inner ecosystem, inulin improves digestion, immunity, and disease-fighting capacity of the body.

GINGER ROOT POWDER (organic)

Ginger rhizome (Zingiber officinale) is an incredibly active and effective gastrointestinal aid with the following properties: 1) Contains a digestive enzyme whose effectiveness even exceeds that of papain; 2) Stimulates the flow of saliva and increases the concentration of the digestive enzyme amylase in the saliva; and 3) Activates peristalsis and increases intestinal muscle tone. Ginger is also known to be helpful in cases of nausea.

BIOVIN® GRAPE EXTRACT

BIOVIN® Grape Pulp, Skin & Seed Extract (>85% OPCs): The BioVin® grape extract in REJUVENATE!™ BERRIES & HERBS is extracted by ethanol and water and contains the highest percentage of OPCs (oligomeric proanthocyanidins) of any product on the market. OPCs, a class of bioflavonoids, are one of nature’s most powerful free-radical scavengers. As bioflavonoids, OPCs help to increase the effectiveness of Vitamin C. OPCs cross the blood-brain barrier to provide antioxidant protection to central nervous system tissue. Studies have clearly demonstrated that OPCs improve and normalize capillary activity, strengthening capillary walls. OPCs bind to collagen fibers, realigning them in the process to a more youthful, undamaged structure. Elasticity, flexibility, and strength are thereby restored to connective tissue.

LICORICE ROOT POWDER (organic)

Licorice root soothes the GI tract and aids intestinal health. Licorice root is used effectively in those individuals suffering from peptic ulcer and chronic gastritis. It is used to soothe coughs and reduce inflammation, soothe and heal ulcers and stomach inflammation, control blood sugar, and to balance hormones. Licorice is a potent antiviral agent and can be used to treat flu, herpes, and even hepatitis. Licorice is also a strong anti-inflammatory agent.

MAGNESIUM (from magnesium ascorbate)

Magnesium is important for the metabolism of many biologically active nutrients and substances, including calcium, potassium, phosphorus, zinc, copper, sodium, lead, cadmium, hydrochloric acid (HCl), acetylcholine, and nitric oxide (NO). It is required for more than 325 magnesium-dependent enzymes, cellular homeostasis, and activation of the B vitamin thiamin. It mediates the functions of the nervous and endocrine systems, supports proper muscle and nerve function, stabilizes heart rhythm, helps to regulate blood sugar levels, and supports normal blood pressure. Magnesium is important in energy metabolism and the synthesis of proteins.

CHLORELLA GROWTH FACTOR (CGF)

Chlorella Growth Factor (CGF) stimulates lactobaccilus (the “good” bacteria) to grow at four times the usual rate. Experiments with microorganisms, young animals, and children have demonstrated that CGF promotes faster than normal growth. In adults and mature organisms, CGF appears to enhance the functions of nucleic acids at the cellular level that relate to the production of proteins, enzymes, and energy. It also stimulates tissue repair and offers protection against toxic substances at the cellular level.

VITAMIN C (from magnesium ascorbate)

Vitamin C is known to perform many critical functions within the body involving detoxification, tissue building, immune enhancement, pain control, and controlling or killing pathogenic organisms. It is known to be helpful for wound and bone healing, healthy skin and eyes, infections, stress control, toxic exposure, and repairing damaged tissue of all types.

ADDITIONAL INFORMATION

Additional Ingredients: Natural Lemon Flavor, Malic Acid, and Stevia Leaf Extract. These natural flavors and taste enhancers give the formula a pleasing taste and make it easier for individuals to consume.

DIRECTIONS: For long-term, gentle rejuvenation of the intestinal tract take about one (1) teaspoon (about 1/3 scoop) several times daily away from food (by at least 20 minutes), or as directed by a health care professional. Place the powder in about 8 ounces of water, thoroughly mix (shake or stir), and drink immediately (before the formula becomes a gel too thick to easily consume).

For a more rapid healing cleanse take one tablespoon (one scoop) multiple times daily away from food (by at least 45 minutes). Add the powder to about 16 ounces of water, mix vigorously, and drink.

We recommend using a suitable container (such as a mason jar) for rapid mixing. Stir rapidly or shake vigorously (with lid attached).

Individuals suffering from conditions of severe diarrhea and loose stools can take one tablespoon (or more) multiple times daily (five times or more) and refrain from food. Put the powder in about 16 ounces of water per tablespoon, thoroughly mix, and drink immediately. In between servings it may be helpful to take a multiple strain lactic acid bacteria formula (i.e., a soil based probiotic such as Prescript-Assist). Place the formula directly in your mouth, chew, and then swallow.

While results can be obtained rapidly using this formula, it is most effective when used for longer-term gentle cleansing. Starting with lower doses and gradually increasing dosage often produces best results. This allows the body time to adjust to increased dosages (size and frequency) and facilitates greater therapeutic action from usage.

Note: Taking large amounts without sufficient liquid (e.g., water) or when first taking the formula can slow bowel transit time. Therefore, most individuals will benefit from starting at lower dosage levels and ensuring adequate fluid intake when consuming the formula.

External Applications: Make paste by mixing powder with water. Apply directly to skin or affected areas (e.g., stings, bites, wounds). Wrap with gauze, plastic, etc., and keep poultice moist. Use for up to six hours. Apply fresh poultice as needed.

Intestinal Rejuvenation Formula does not contain wheat, gluten, rye, oats, corn, barley, soy, yeast, egg, sugar, dairy products, GMOs, wax, animal fats, preservatives, colorings, or artificial flavorings.

RESOURCES

ARTICLES

Gut Health – Intestinal Rejuvenation Formula

Dr. Mark Sircus’s blog article at www.DrSircus.com:
“Apples – Pectin – Intestinal Formula”

Kidney Cleansing with Juices & Herbs

Liver Cleanse with Juices & Herbs

Rejuvenation Program: Part 2 (Detoxification)

Death by One (Or Two) Thousand Cuts

Microbiome, Diet, and Prescript-Assist Probiotic and Prebiotic

Chemical / Environmental Toxicity Syndrome Protocol

Super Remedies for Stings and Bites

Understanding Glyphosate Toxicity: Interview with Genetic Engineer Thierry Vrain (Mother Earth News)

BOOKS

The Colon Health Handbook by Robert Gray

Brain Maker: The Power of Gut Microbes to Heal and Protect Your Brain for Life by Dr. David Perlmutter

Grain Brain: The Surprising Truth About Wheat, Carbs, and Sugar – Your Brain’s Silent Killers by Dr. David Perlmutter

Wheat Belly: Lose the Wheat, Lose the Weight, and Find Your Path Back to Health by Dr. William Davis

PRODUCTS

INTESTINAL REJUVENATION FORMULA

PRESCRIPT-ASSIST™ Probiotic Formula
(soil-based organisms)

RESTORE For Gut Health

PROLYT
(proteolytic enzymes)

DIGASE
(full spectrum plant enzymes)

Nascent Iodine

Magnesium Oil, Flakes, Gel

2

QUICKSILVER LIPOSOMAL FORMULAS – NEW PRODUCTS!

Fred Liers PhD quicksilver liposomal formulasOne of the most significant developments for nutrient uptake and assimilation is the advent of liposomal delivery systems. Once in the range of 300–5,000 nanometers, the latest liposomes are now just 20–100 nanometers (nm)!

The significance of these small liposomes—tiny bilayer lipid structures—is that there is a major increase in the amount of nutrient delivery to cells. That is, small liposomes show significantly greater efficiency at intracellular delivery of encapsulated compounds.

Liposomal delivery systems have evolved rapidly and now offer major advantages over nutritional supplements delivered by standard means—like capsules, tablets, powders, and liquids (e.g., tinctures).

Liposomal delivery systems first utilized multi-lamellar vesicles (MLV) ranging ins size from 300–5,000 nanometers. Later, “large” unilamellar vesicles (LUV) (100–300 nanometers) were developed. Products containing LUVs are more effectively assimilated than MLVs.

As noted, lipsomal technologies have shrunk liposome sizes to 20–100 nanometers (nm), the category size for small unilamellar vesicles (SUV). This means the body can far more easily assimilate nutrients delivered liposomally when the particle sizes are up to 10 times smaller than already effective liposome sizes.

Small liposomes (SUV) have a long circulation half-life and better cellular accumulation. Small lipid particles have the fastest uptake kinetics and can participate in paracellular (between cells) transport. The nutritional liposome industry is rapidly moving toward the use of small liposomes.

Key Point: Small liposomes (SUV) are significantly more efficient at intracellular delivery of encapsulated compounds. In a recent study with carefully sized liposomes, cellular uptake increased nine-fold as liposome size was decreased from 236 nm to 97 nm and was 34 fold higher at 64 nm.

Nutrients that can be delivered liposomally range from vitamin C and glutathione to many types of adaptogenic and medicinal herbs.

Benefits of Liposomal Delivery

  • Rapid update, assimilation, and movement into cells
  • Oral intake bypasses digestive system—nutrients go directly into body
  • High levels of nutrients assimilated
  • Reduced dosages and less “wasted” product
  • Nutrients penetrate smallest compartments in the body
  • Nutrients circulate widely
  • Precise intra-oral delivery
  • Simple manual pump from glass bottle
  • Easy water dispersability when desired
  • Good tasting!

Liposomal delivery systems are the future of nutritional supplements given all the advantages they confer. HPDI recognizes the value of liposomal products, and now offers the best formulas available—from Quicksilver Scientific, Inc.—to our customers.

QUICKSILVER LIPOSOMAL FORMULAS

HPDI offers four liposomal formulas from Quicksilver Scientific, the leader in nanoliposomal delivery systems. Each formula offers unparalleled uptake and assimilation—and good taste!—via inta-oral delivery. These products include:

Quicksilver liposomal formulas

HPDI offers four liposomal formulas from Quicksilver Scientific.

Liposomal Vitamin C with R-Lipoic Acid (mean size 50–100nm): Quicksilver Scientific’s Etheric Delivery™ system for Liposomal Vitamin C (with R-Lipoic Acid) is the most absorbable form of professional-grade Vitamin C. Vitamin C is essential to any detoxification program because it feeds the system that eliminates toxins. It is also very effective in removing lead and other heavy metals from our system and fighting off the free radicals that form in the liver during the first phase of detoxification.

R-Lipoic Acid (as sodium R-Lipoate) has an exceptionally well-documented ability to upregulate the glutathione system via the Nrf2 nuclear transcription pathway. This combination of liposomal vitamin C and R-Lipoate in a nanoliposomal delivery system potently harnesses the potential of Vitamin C to the power of a fully functioning glutathione system.

The absorption of conventional oral Vitamin C diminishes rapidly as the dose increases (e.g., about 19% for 1000 mg oral vitamin C). Nanosphere delivery greatly increases absorption and for some compounds can provide higher intracellular delivery than an IV administration.

Quicksilver Vitamin C

Quicksilver Liposomal Vitamin C with R-Lipoic Acid

Suggested Usage: General use for antioxidant and detoxification function, take eight pumps per day (1,000 mg of Vitamin C and 50 mg of R-Lipoate). For advanced intermittent use, use up to 50 pumps per day (6,250 mg Vitamin C and 312.5 mg R-Lipoate) or more, in divided doses throughout the day. For detoxification protocols, especially with metal toxicities, build dosage gradually, starting from low doses, as they are tolerated. If strong detoxification reactions are observed, back off dosage. Children should start at approximately 1/4 of adult (two pumps per day) dosage and work up. For topical application, one pump can cover the face for a daily treatment, or use several pumps as a mask and leave on for 10–15 minutes; skin can be re-wetted and left for another 10 minutes before rinsing off excess.

Liposomal Glutathione: Quicksilver’s Phospholipid Encapsulation Etheric Delivery system protects glutathione from digestive enzymes that otherwise inhibit absorption of oral glutathione supplementation. In cell cultures, liposomal products have demonstrated over 100 times more efficiency for intracellular delivery than IV-based liposomal glutathione.

Quicksilver’s Liposomal Glutathione comes with a precision pump to accurately deliver 50 mg of reduced glutathione and 68 mg of injectable-grade essential phospholipids (derived from sunflower oil) per pump. The patent-pending process, plus a natural lemon flavoring, allows this product to be taken intra-orally for maximum absorption without the foul sulfur taste typical of liposomal glutathione products. The formula can be taken every 3–4 hours for even delivery throughout the day. One bottle delivers 100, 0.5 ml doses.

Quicksilver Liposomal Glutathione

Quicksilver Liposomal Glutathione with Lemon Mint

Suggested Usage: For general antioxidant and detoxification protection, use eight pumps per day (400 mg glutathione). For advanced protection, use up to 20 per day (1,000 mg glutathione) or more, in divided doses throughout the day. For large doses, take two pumps at a time to allow for maximum oral absorption, and hold at least 30 seconds before swallowing. Children should start at approximately 1/4 of adult (two pumps per day) dosage and work up.

Liposomal Colorado Hemp Oil: This product uses non-THC (<0.3%) cannabidiol (CBD) from all-natural Colorado Hemp Oil. CBD is the non-psychoactive part of the industrial hemp plant. Quicksilver Scientific’s liposomal delivery of Nanoemulsified Colorado Hemp Oil far outpaces tinctures and is faster, stronger and more effective. Cannabidiol interacts with our body’s naturally occurring cannabinoid receptors to aid with pain relief and enhanced feelings of well being. The advanced technology behind this groundbreaking liquid delivery method makes for precise dosing and immediate effect.

Because of the known interaction of CBD with these cannabidiol receptors, much new research has focused on CBD’s receptor-mediated neuro-protective, antiemetic, and analgesic properties, and of its effect on mood and other aspects of mental health.

New research on gene transcription modulation offers an even deeper look into the biochemical mechanisms at work when ingesting CBD. Research in this vein has shown more than 1,000 genes that are differentially upregulated by CBD (a more than ten-fold increase than those affected by THC). In general, the effects increased cell stress responses—including antioxidant-defense and detoxification genes (mainly via EhRE/ARE-Nrf2 induction)—and downregulated many inflammation-mediating genes. These effects combined with CBDs NMDA-receptor-stabilizing effects, show great promise for its use in calming the neuro-inflammatory responses accompanying neurotoxic and chronic illness states.

Quicksilver Nanoemulsified Colorado Hemp Oil

Nanoemulsified Colorado Hemp Oil

Suggested Use: Take 1–4 pumps by mouth, holding for 30 seconds before swallowing. Repeat if needed. Four pumps contain 30 mg of Hemp Extract (aerial parts) and 12 mg of Phytocannabinoid Diols. There are 25 four-pump servings per container. Best taken on an empty stomach 10 minutes before meals. May be stirred into a small amount of water. Once opened, use within 60 days. Store at room temperature and away from light.

Liposomal NanoMojo (adaptogenic blend): Dr. Christopher Shade, PhD of Quicksilver Scientific, collaborated with master herbalist Dan Moriarty of Sun Horse Energy to create NanoMojo, a groundbreaking functional medicine product. By combining Moriarty’s unique adaptogenic formulation with Dr. Shade’s state-of-the-art liposomal encapsulation, they’ve overcome the limitations of poor oral adsorption and made the phytochemicals quickly available at the cellular level. This new innovative blend of adaptogens from around the world is maximized for effectiveness.

Adaptogens are non-toxic phytochemicals that help the body achieve homeostatic balance under adverse conditions that would typically be associated with sympathetic (fight or flight) reactions. They help regulate natural harmony, adrenal balance, and stress accommodation (resistance to stress). In fact, adaptogenic herbs have been used in Ayurvedic medicine for more than 4,000 years and Chinese medicine for nearly 3,000 years to increase energy (chi) and concentration.

Scientific literature reports that adaptogenic herbs play significant roles in decreasing markers of stress-activated protein kinases, cortisol, and nitric oxide. These markers indicate a lowered level of systemic stress and inflammation and decreased symptoms of an over-taxed adrenal system.

NanoMojo contains the following adaptogenic herbs: Açaí, Lyceum (Goji) fruit, Gynostemma (Jiaogulan) (aerial parts), American Ginseng (root), Siberian Ginseng (root), Schisandra (fruit), Licorice (root), Rhodiola (root), Astragalus (root), Reishi (fruiting body), Catuaba (bark), Stinging Nettle (aerial parts), Saw Palmetto (fruit), Guarana (seed), Ashwagandha (root), Tribulus (aerial parts), Epimedium (aerial parts), Yohimbe (bark), and Organic Maple (sap) syrup.

NanoMojo helps your body adapt to the various conditions that cause stress, something most of us experience daily. This liposomal formulation is the culmination of more than eight years of research and development. Not only is it effective, but it also tastes very good.

Quicksilver liposomal NanoMojo adaptogens

NanoMojo Liposomal Adaptogenic Blend

Directions: Take two pumps twice daily, or more. May be mixed into a small amount of water. Best taken on an empty stomach. Once opened, use within 60 days.

CONCLUSION

The advent of small liposomes means significantly greater uptake and assimilation of nutrients than ever before. This means you stand to benefit greatly from advanced intra-orally delivered nanoliposomal formulas like those developed by Quicksilver Scientific, Inc.

 

 

SOURCES & RESOURCES

ARTICLES

Recent Advances in Liposome Technology (HPDI blog)

PRODUCTS

Quicksilver Scientific Liposomal Formulas (HPDI website)

Liposomal Vitamin C with R-Lipoic Acid

Liposomal Glutathione with Lemon Mint

Nanoemulsified Colorado Hemp Oil

NanoMojo Liposomal Adaptogenic Blend

 

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KIDS VITAMINS – NO KIDDING!

Fred Liers PhD kids mighty multi multivitamin chewableLooking for a high-quality, natural KIDS MULTIVITAMIN? Me, too. Do you look in vitamin stores, natural foods stores, and online marketplaces—in vain? I have.

A couple years ago, HPDI’s formulator, my father Hank Liers, PhD decided to reformulate our already excellent kids multivitamin—the Kids Mighty-Multi!—to make it better. His intentions were good: the world’s best designer of adult multivitamins would improve the best children’s vitamin.

My quandary? While Dr. Hank was busy at work reformulating our kids multi, the existing—and uber-excellent—original Kids Mighty-Multi! went out-of-stock, and never came back. Suddenly, my seven-year-old son’s “go-to” multivitamin was gone…indefinitely!

I took action—kids vitamins became my obsession—because I wanted the best multivitamin for my child. I searched everywhere for high-quality kids vitamins. Leaving no stone unturned, we tried them all—including organic, whole food, gluten-free, vegan-friendly brands with glossy labels. Did we find good ones? Not really.

What DID we find? Well, not much—and a lot. That is, not much in the way of high potency, high-purity, or advanced forms, like coenzyme vitamins. And a lot of false promises and junk ingredients. Like sugar and corn syrup and GMO ingredients—even from “reputable” brands.

Not to mention artificial sweeteners, colorings, flavorings, as well as toxic preservatives and fillers, which are the de facto standard in conventional products. Natural products are better—not always by as much as you’d expect.

chewable kids mighty-Multi! multivitamin

Looking for a good children’s multivitamin? Look no further than chewable Kids Mighty-Multi!

MY MULTIVITAMIN WISHLIST

Now in label-induced miasmic SHOCK…I proposed a reversal of terms. I simply wanted a lot of good things—like complete, balanced nutrients—and not much in the way of toxic additives.

Reeling, I scrawled a brief manifesto or “wishlist” for my ideal kids multivitamin:

“Great taste, high-purity, balanced nutrients at optimal levels, chewable; sugar free, non-GMO. No artificial ingredients, especially toxic sweeteners like aspartame or sucralose. No harmful additives or preservatives like sodium benzoate, BHT, or propylene glycol (no antifreeze please!); a few good-for-you functional ingredients.”

Was I asking *too* much? No way. Yet, I was giving up on finding a suitable kids multivitamin. My son instead began taking an HPDI adult multivitamin (Multi Two Caps) we scaled to his sixty five-pound weight. The taste wasn’t great—so we opened capsules directly into his juices and smoothies—because he’s not ready to swallow capsules or tablets whole. At best…a partial solution.

KIDS MIGHTY-MULTI! BACK — BETTER THAN EVER!

Then. It. Happened. Lighting struck—HPDI’s Kids Mighty-Multi! is BACK! Turns out my dad finished reformulating the world’s best kids multivitamin. He broke the news with a smile. Stunned and unbelieving…I took a breath. My heart skipped a beat. Then I grabbed a bottle!

Who knew it would take two years?—and now, who cares!? This month, HPDI proudly introduces a *new* Kids Mighty Multi!. Worth the wait? Yes. Because the new version is better than ever.

I’ve thrown away my wishlist. My search is over. Yours may be, too. Because no kids multivitamin comes *close* to Kids Mighty-Multi!. See the comparison chart and nutrient table (below).

A SERIOUS VITAMIN FOR KIDS – FINALLY!

What makes the new Kids Mighty-Multi! so good, and so much better? Let me count the ways. Here is a summary of benefits before I dive into discussing them in greater detail.

• Kids and adults love the taste!

• Full-spectrum of balanced, essential nutrients needed for creating, supporting, and maintaining excellent health for your child. Includes natural coenzyme form vitamins and Krebs’ cycle bionutrients that work with young bodies to provide energy for metabolic processes, healing, and optimal health.

• Bioavailable vitamin and mineral carriers the body recognizes and can assimilate rapidly. Plus, multiple carriers of individual nutrients ensure assimilation. Chewable form speeds uptake in the body.

Variety of well-known herbal ingredients, including quercetin, grape extract, turmeric, broccoli powder, and octacosanol

Complete, balanced supply of carotenoids, including beta-carotene, lycopene, and lutein

Functional ingredients built into every aspect of the formula, including the taste-enhancing package, herbal ingredients, and cofactors. Functional ingredients serve multiple purposes in supporting health.

• Flavored using only healthy, natural sweeteners and taste enhancers, including mannitol, fructooligosaccharides (FOS) (from chicory root), organic beet root powder, natural fruit flavor, xylitol, and stevia leaf extract. Taste enhancers exhibiting additional positive benefits (i.e., prebiotic effects, cavity prevention, and antioxidant action).

• NO refined sugars, no corn syrup, and…NO GMOs!

• NO artificial colorings or flavorings, artificial sweeteners (like aspartame, saccharin, or sucralose), or hydrogenated vegetable oils

• Excludes common food source allergens like wheat, corn, soy, and dairy

• Excludes unnecessary excipients, including fillers, binders, and additives

• Foundational formula ideal for providing basic nutrients for health. A high-quality multivitamin is the first step toward a complete nutritional supplement regimen. Formulated to work well with other HPDI foundational formulas, such as vitamin C / antioxidant formulas (like PRO-C™) and essential fatty acids (like Essential Fats plus E).

Kids Multivitamin comparison chart

TASTE-ENHANCING COMPLEX: FUNCTIONAL INGREDIENTS

Kids Mighty-Multi! tastes GREAT! Kids and adults LOVE the taste. From the perspective of your child’s taste buds, that’s *all* that matters.

But I want to talk a bit about the importance of healthy sweeteners…and how the best sweeteners perform double duty as health promoters.

WHY does Kids Mighty-Multi! taste so good? (Did I mention it contains NO refined sugars—or any artificial sweeteners or flavorings?)

Because Dr. Liers created a natural taste-enhancing complex. This taste-enhancing package includes xylitol, mannitol, FOS (fructooligosaccharides), beet root juice powder, natural fruit flavors, and stevia leaf extract.

Dr. Hank selected healthy, functional ingredients—as much as possible—in order to enhance the taste. That means these taste enhancers are not only NOT unhealthy like the refined sugars, corn syrups, and artificial sweeteners I found in so many other kids vitamins. But they are GOOD for you!

Functional sweeteners and taste-enhancing ingredients in Kids Mighty-Multi! include:

Xylitol – Proven sweetener that is a polyol (sugar alcohol) known to fight cavities, improve bone health, and more! (see: http://xylitol.org/about-xylitol/)

Mannitol – Natural polyol sweetener with added benefits as an antioxidant. Mannitol surprisingly has a very powerful effect on the hydroxyl free-radical. (see: https://www.ncbi.nlm.nih.gov/pubmed/9090754). Mannitol serves double duty as a healthy sweetener and important hydroxyl radical free-radical trapper.

• Fructooligosaccharides (FOS) (from chicory root) – Naturally sweet with no or low glycemic index. It is also a prebiotic that supports the growth of beneficial bacteria.

• Beet Root Powder (organic) – Naturally sweetens and colors Kids Mighty-Multi!. Beet is a functional ingredient providing methyl donors and easily assimilable iron. Moreover, Dr. Benjamin S. Frank found beets contain an amino acid the body uses to create its own dietary nucleic acids and a nutrient important to brain function (No-Aging Diet, 81).

• Berry & Fruit Extracts / Flavors – Mixed berry, strawberry, raspberry, and pomegranate. These berry extracts provide extremely good, fruity taste—bursting with berry flavors!

• Stevia Extract – Natural sweetens with little or no glycemic value. Kids Mighty-Multi! contains a newer, improved stevia extract which is de-bittered

• Malic Acid – Provides a naturally tart taste, supports the utilization of magnesium, and feeds into the Krebs’ cycle that makes cellular energy (ATP)

Why is choosing “good-for-you” functional sweeteners and taste enhancers important?

Because despite what adults might wish, sweeteners still comprise the largest percentage of kids multivitamins by weight. That means your child will be ingesting significant amounts (of whatever these sweeteners are) relative to the size of their multivitamin.

Who wants the bulk of their child’s multivitamin intake comprised of sugars, corn syrup, sucralose, or worse (think aspartame)? This is the reason natural sweeteners providing functional benefits make all the difference for health.

COMPLETENESS MATTERS – A LOT!

Kids Mighty-Multi! is nothing if not complete. As formulated by Dr. Hank Liers, it provides therapeutic levels of all essential vitamins, minerals, cofactors, and much more.

If you read labels (like I do), you’ll see most kids vitamins are “hit-or-miss.” They provide certain nutrients, but often completely miss others—usually with no rhyme or reason. (What was its formulator thinking?)

Missing important nutrients is bad for consumers—like you and your child—because all nutrients require other nutrients to “do a body good.” It’s called synergy, and it’s the way our cells are designed to work.

That means if you obtain sufficient amounts of a specific nutrient, but not enough of another, you may be unable to effectively utilize the nutrient you have—because utilization requires the nutrient you *don’t* have. Catch-22, huh? I’ll talk more about this later.

Do your child—and yourself—a favor: choose a complete multivitamin like Kids Mighty-Multi!.

kids mighty multi multivitamin

Kids Mighty-Multi! is nothing if not COMPLETE. (Tablets in photo appear larger than actual size.)

ADVANCED FORMS OF NUTRIENTS…LIKE YOU’VE NEVER SEEN

Then, there are advanced forms of nutrients, like coenzyme B vitamins. Most kids vitamins (and adult multivitamins) offer you the B complex vitamins as synthetic forms. How can you tell? Well, coenzyme vitamin B1 in Kids Mighty-Multi! is from Thiamin Diphosphate and is very different from synthetic “thiamine HCl.” Vitamin B2 is from Riboflavin-5′-Phosphate is not synthetic “riboflavin.” The vitamin B6 is from Pyridoxal-5′-Phosphate is not “pyridoxine HCl.” And so on.

What about vitamin B12 as toxic “cyanocobalamin”? Never. Kids Mighty-Multi! provides coenzyme B12 as methylcobalamin. Other brands sometimes use this form, but then provide synthetic forms for other B vitamins. That makes sense—NOT.

Sure, coenzyme B vitamins cost more to source. But the truth is, your body requires far less coenzyme form vitamins because they are the natural forms found in foods—you easily assimilate and utilize them. Kids Mighty-Multi! doesn’t need large amounts of coenzyme vitamins to give you big benefits.

Meanwhile, synthetic forms are not as easily assimilated—most go through a complex enzymatic breakdown before the body can use them. In some cases (for example if your child lacks certain enzymes due to genetics), syntethic forms cannot be broken down—or used—at all!

Case in point: Folate. Most kids vitamins give you “folic acid,” which is synthetic vitamin B1. A large percentage of the population (including me) lacks the gene providing the enzyme required to process folic acid. If folic acid builds up in cells (because it can’t be broken down), then it can be toxic. Solution: we use coenzyme folate—or 5-MTHF (5-methyl tetrahydrofolate) in Kids Mighty-Multi!. Problem solved.

Recall I said Kids Mighty-Multi! is complete?—and the importance of completeness in a multivitamin? Well, for example, if your kids’ multivitamin only provides synthetic vitamin B6 (as Pyridoxine HCl), it won’t be convertable into its biologically active (coenzyme) form without coenzyme vitamin B1 (Riboflavin-5′-Phosphate).

Did you catch that? To convert Pyridoxine HCl (synthetic vitamin B6) to its usable coenzyme form Pyridoxal-5′-Phosphate, you need coenzyme Riboflavin (Riboflavin-5′-Phosphate). You need a coenzyme form of one B vitamin in order to convert another B vitamin to its coenzyme form!

If you have only synthetic forms of these B vitamins, your body must go through multiple conversion processes in order to first convert synthetic Riboflavin into coenzyme Riboflavin so that you can convert synthetic vitamin B6 (Pyridoxine HCl) into its coenzyme B6 form (Pyridoxal-5′-Phosphate).

Yes, you can *survive* on synthetic forms of B vitamins. But why make your body work so hard? Why survive when you can *thrive* (with coenzyme vitamins)?

Why other kids vitamins don’t include coenzyme forms is BEYOND ME. If other brands go with conventional (and sometimes toxic) synthetic forms, so be it. Run, and go with Kids Mighty-Multi!.

Other advanced forms include vitamin D as D3 (cholecalciferol), vitamin K as K1 and K2 (Menaquinone-7), and minerals using Krebs’ cycle carriers (like citrates, malates, fumarates, succinates, and aspartates) that are best recognized and utilized in the body because they plug into the body’s energy (ATP) production system.

KIDS MIGHTY-MULTI!™ NUTRIENT TABLE

NUTRIENT

AMOUNT

% Daily Value

Vitamin A
(as beta-carotene from Dunaliella salinas)
470 IU 10
Vitamin C
(from potassium, magnesium, and calcium ascorbates)
16 mg 27
Vitamin D3 (as cholecalciferol) 50 IU 13
Vitamin E (from d-alpha tocopheryl succinate and 5 mg natural mixed tocopherols) 13 IU 42
Vitamin K (10 mcg as phylloquinone (K1) and 5 mcg as MK-7 (K2)) 15 mcg 18
Vitamin B1 (from thiamin diphosphate) 1.6 mg 107
Vitamin B2 (from riboflavin-5′-phosphate) 1.6 mg 94
Vitamin B3 (80% from niacinamide and 20% from niacin) 12 mg 60
Pantothenic Acid (from calcium pantothenate) 5 mg 50
Vitamin B6 (from pyridoxal-5′-phosphate) 2.5 mg 125
Vitamin B12 (as methylcobalamin) 15 mcg 250
Folate (from 5-MTHF – Quatrefolic®†) 50 mcg 13
Biotin (pure crystalline) 30 mcg 10
Magnesium (from malate) 6 mg 1.5
Calcium (from Krebs cycle bionutrients) 6 mg 0.6
Potassium (from citrate) 4.7 mg <1
Zinc (from citrate) 1.25 mg 8.3
Iron (from fumarate) 0.3 mg 1.7
Manganese (from citrate) 0.3 mg 15
Copper (from aspartate) 0.125 mg 6.3
Chromium (from polynicotinate) 13 mcg 11
Molybdenum (from citrate) 6 mcg 8
Selenium (from l-selenomethionine) 5 mcg 7
Choline (from bitartrate) 6 mg *
Inositol (pure crystalline) 15 mg *
N-Acetyl-L-Cysteine (NAC) 5 mg *
L-Taurine 5 mg *
Betaine HCl 3 mg *
Quercetin (as dihydrate) 3 mg *
Turmeric (from Curcuma longa) (root) 3 mg *
Broccoli Sprouts Powder 2 mg *
Grape Extract (Vitis vinifera) (from seed, skin, and stem) 1 mg *
Lycopene (tomato extract) (fruit) 200 mcg *
Boron (from glycinate and aspartate) 125 mcg *
Lutein (from Calendula officinalis) (flower) 70 mcg *
Octacosanol (from policosanol) 15 mcg *
Vanadium (from BGOV – bis glycinato oxo vanadium) 6 mcg *

* No established Daily Value
† Quatrefolic® is a registered trademark of Gnosis SPD

SCALABLE DOSING – CALLING ALL KIDS – AND ADULTS!

Maybe the best feature of Kids Mighty-Multi! is scalable dosing. Scalability makes it suitable for children and youth of all sizes—and adults, too!

Glancing at Kids Mighty-Multi!‘s label, you might assume it’s as low potency as the most kids’ vitamins available in stores. Not so fast.

Because Dr. Hank designed this multivitamin for everyone, including adults. How do I know? Because he told me: he takes these chewables himself!

How does it work? You simply take two (2) tablets per 20 pounds of body weight—up to six tablets—for kids. But since most older kids and adults weigh more than 60 pounds, you can take 8–10+ tablets and approximate the nutrition you would get from your regular adult vitamin. How cool is that!

Scalable dosing works well for people who don’t like swallowing capsules or tablets, or who prefer a good-tasting chewable. And who doesn’t, sometimes? It is especially useful for traveling because the entire family can use it.

In my case, I usually take four capsules per day of Hank & Brian’s Mighty Multi-Vite! , which my favorite adult multivitamin, and the inspiration for creating the Kids Mighty-Multi!. Yet, there are many days when I thrill to the taste of the new chewable kids multivitamin—knowing I get a significant amount of nutritional value. That means a lot. A lot of goodness. And not much to worry about.

Chewable Kids Mighty-Multi! multivitamin

Dr. Hank Liers pulled out the stops in formulating Kids Mighty-Multi!

CHOOSE KIDS MIGHTY-MULTI!

You’ve got choices. You can go online or to your local natural market, pharmacy, or big box store and fill up on whatever kids vitamins you find. Take your chances. Or you can try Kids Mighty-Multi! to discover how good a children’s multivitamin can (and should) be—a truly superior formula.

Choose our awesome kids multivitamin. Dr. Hank did his job. We’re 110% confident it meets—or exceeds—the needs and expectations of your child, and likely you, too. And definitely those of your clients, if you’re a health professional.

Of course, you’ve got a brain. But this choice is a “no-brainer.” Go for Kids Mighty Multi!. Your kids will never go back to their old multivitamin. And they’ll be healthier for it.

 

SOURCES & RESOURCES

Products

Kids Mighty-Multi! Multivitamin

HPDI Multivitamins

References

Coenzyme Vitamins (HPDI)

Fructooligosaccharides Abstracts (HPDI)

Statement on Additives (Excipients) (HPDI)

The HPDI Difference: Four Pillars of Excellence

Percent Daily Values (DV) Calculation Table (FDA)

Xylitol.org

Dr. Frank’s No-Aging Diet
by Benjamin S. Frank, MD, PhD

Studies

Oxygen free radical scavenging abilities of vitamins C and E, and a grape seed proanthocyanidin extract in vitro.” Res Commun Mol Pathol Pharmacol. 95(2):179-89.
(Study includes mannitol benefits)

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RECENT ADVANCES IN LIPOSOME TECHNOLOGY

Dr. Hank Liers, PhD liposomes liposomal nutrientsHealth Products Distributors, Inc. recently decided to augment the variety of liposomal products we carry based upon the significant advancements of the technology during the last few years.

Among the benefits of using liposomes are that significantly higher levels of certain nutrients can be delivered directly to the cells where they are needed. In this article, I will discuss some of the recent scientific advances and new products associated with these advances.

Types of Liposomes

Figure 1 – liposomal types

SMALLER IS SIGNIFICANTLY BETTER

In December 2015, I wrote a blog article on liposomes to introduce the liposomal products we began selling at that time. Unfortunately, the particle size of these original products are on the order of 500 nanometers (nm), and as such are not nearly as well absorbed as the much smaller liposomes that have recently been developed by Quicksilver Scientific.

Figure 1 gives an overview of current liposome types. These include multi-lamellar vesicles (MLV) that range in size from 300–5,000 nm and have more than one bilayer.

Large unilamellar vesicles (LUV) range in size from 100–300 nm. They have a single bilayer and a high trapped volume, but have lower thermodynamic stability and decreased uptake.

Small unilamellar vesicles (SUV) range in size from 20–100 nm. SUV have a long circulation half-life and better cellular accumulation. Small lipid particles have the fastest uptake kinetics and can participate in paracellular (between cells) transport. The nutritional liposome industry is moving toward the use of SUV.

Small liposomes (SUV) are drastically more efficient at intracellular delivery of encapsulated compounds. In a recent study with carefully sized liposomes, cellular uptake increased nine-fold as liposome size was decreased from 236 nm to 97 nm and was 34 fold higher at 64 nm (see Figure 2). This figure shows flow cytometry results (a measure of cellular uptake) for Caco-2 cells incubated with liposomes containing Dil-C18 at 15 min and 60 min intervals.

Size effects of liposomes for cellular uptake

Figure 2 – Chart showing greatly enhanced absorption of liposomes as size decreases

 

HPDI CARRIES NEW LIPOSOMAL PRODUCTS

Our new liposomal product supplier currently is providing a wide range of products that have stable liposomes of about 50 nm. These products are bottled in such a way that they are taken by pumping (or squirting) the contents directly into your mouth (i.e., oral administration). This is an extremely clean method of dosing in which a few pumps of liposomal liquid can be rapidly taken or administered with no need for placing the product into separate glass of water or squeezing packets.

Because of the very small size much of the ingredients are absorbed through mucus membranes and into the system and cells extremely quickly (within seconds/minutes). In addition to the ingredients within the liposome, one gets significant amounts of phosphytidal choline into the cell membranes with a very beneficial effect on membrane function.

We are currently carrying the following Quicksilver Scientific liposomal products:

  1. Vitamin C with R-Lipoic Acid
  2. Glutathione
  3. Colorado Hemp Oil
  4. NanoMojo – a unique combination of 19 adaptogenic herbs

Quicksilver Liposomes

We highly encourage that you use the products because of the huge benefits they provide. We use them ourselves every day.