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PRO-C ANTIOXIDANT FORMULA UPDATE + VIDEO

Dr. Hank Liers, PhD pro-c™ pro-c super antioxidant formulaFred Liers PhD pro-c antioxidant vitamin c nrf2 formulaLooking for an advanced antioxidant formula? Already using or recommending vitamin C? Curious about cellular Nrf2 activation? Look no further than PRO-C™.

PRO-C™ is among the most effective antioxidant formulas available. It is an HPDI foundational supplement that works most effectively when used with multivitamins, essential fats, and superfoods. However, it is also an excellent standalone formula that can rapidly provide the body with extremely high protection from free radicals.

We ourselves have taken PRO-C daily for many years with excellent results. Our personal experience together with detailed feedback from health professionals and end-users affirms the effectiveness of PRO-C as a super-antioxidant–vitamin C-Nrf2 activator formula.

PRO-C provides 500 mg of buffered vitamin C per capsule (buffered with calcium, magnesium, and zinc) along with grape extract (seed, skin, pulp) and green tea extract (95% polyphenols). In addition, we include a special combination of the “network antioxidants” l-glutathione (reduced), n-acetyl-l-cysteine (NAC), r-lipoic acid, and selenium. Vitamin B2 and Vitamin B6 in coenzyme forms support the enzymatic effectiveness of the “network antioxidants”. The formula works so well because this combination of ingredients leverages the antioxidant power of vitamin C, grape extract, green tea extract, and the other nutrients to act synergistically in order to maximize effectiveness.

FORMULATION HISTORY AND THE SCIENCE BEHIND PRO-C™

What you may not know is the history of the development PRO-C and the scientific knowledge on which Dr. Hank Liers based his formulation of it.

Dr. Hank formulated his first product in 1989. It was a potent antioxidant formula he called PYC-C™ (sounds like “pixie”). PYC-C consisted of a combination of buffered Vitamin C (including magnesium, calcium, and zinc ascorbates) and pycnogenols from pine bark.

Much of the scientific research data Dr. Hank collected during the development of PYC-C regarding oligomeric proanthocyanidins (OPC) he later incorporated into an article (currently published on this blog) titled “Review of Scientific Research on Oligomeric Proanthocyanidins (OPC)” (rev. 2017)

By 1997 Dr. Hank had gathered a great deal of new scientific information regarding green tea catechins and the nutrients termed “network antioxidants” by Dr. Lester Packer, director of Packer Lab at University of California, Berkeley. Beyond this information, Dr. Hank studied additional research regarding how various nutrients worked together synergistically. At that point, he was ready to formulate the new, improved PRO-C™ super antioxidant formula.

PRO-C combines the ingredients of PYC-C (now known as OPC-C™) and uses grape pulp, skin, and seed extract with green tea extract (with high polyphenols >95% and EpiGalloCatechinGalate (EGCG) >45%), n-acetyl-l-cysteine (NAC), reduced glutathione (GSH), R-lipoic acid, selenium, and coenzyme Vitamins B2 and B6.

PRO-C super antioxidant formula 180 cap 90 cap

HPDI launched PRO-C™ in late 1997. It rapidly became one of our best-selling products. Our customers raved about how effective it was for them if they felt like they were “coming down with something” (like a cold, flu, virus, infection, etc.). Greater skin elasticity greatly helped pregnant women avoid stretch marks and episiotomies. Today, we highly recommend its use together with our other Foundational Supplements to ensure optimal health and anti-aging effects.

THE PRO-C™ SUPER ANTIOXIDANT FORMULA

PRO-C™ super antioxidant formula is extremely synergistic, especially in so far as it increases the body’s ability to quench free radicals in its aqueous (i.e., water-based) compartments. Because antioxidants may become free radicals themselves after they have done their job, the body has developed an elaborate system for recovery of oxidized antioxidants.

 

Dr. Lester Packer was the primary researcher investigating the synergistic character of antioxidants. He made this statement in his interview with Dr. Richard Passwater after publication of Packer’s The Antioxidant Miracle (1999):

[The major theme of] The Antioxidant Miracle is that antioxidants work in a coordinated manner. They interact with one another, and this interaction, which we like to call the antioxidant network, is very important to the overall antioxidant defense that we possess. The key members of the antioxidant network are vitamin E and vitamin C, but there are other participants in this network. These are thiol antioxidants, antioxidants that contain sulfur groups in the body. Glutathione perhaps is the best known of these, but there are other sulfur-containing antioxidants that also are very important.”

Dr. Packer continues:

“This whole antioxidant network works like an orchestra depending on individuals who have, of course, different complements of antioxidants depending upon their nutritional regimens and the individuality of their own body metabolisms. The idea behind having a network of antioxidants is that if one antioxidant happens to be deficient the others can compensate and still keep the antioxidant defense system strong.”

The following diagram shows some of the relationships in the antioxidant network and how they support each other.

Lester Packer antioxidant network diagram Figure 1 – Dr. Packer’s Antioxidant Network

We see, for example, reduced glutathione (GSH) has the ability to reduce oxidized Vitamin C back to its unoxidized state. Vitamin C reduces oxidized Vitamin E back to its unoxidized state, and both reduces glutathione and spares it for other important functions, including detoxification and immune enhancement.

Many polyphenols (e.g., oligomeric proanthocyanidins (OPCs), anthocyanidins and catechins) found in red grape and green tea extracts spare Vitamin C and glutathione in the body, as well as operate as powerful antioxidants, anti-inflammatories, and connective tissue strengtheners.

grapes grape extract antioxidant

Grapes provide antioxidant nutrients such as polyphenols, OPCs, anthocyans, and resveratrol.

R-Lipoic Acid (see abstracts below) operates as an antioxidant both in its oxidized and reduced states, reduces the oxidized forms of both Vitamin E and Vitamin C, and and has been shown to enhance glutathione levels. Because several of these substances are able to protect Vitamin E contained in cell membranes, this combination also has a significant beneficial effect on the fat soluble antioxidant status of the body!

The nutrients in PRO-C have been carefully selected and balanced to provide optimal effects, especially as related to free radical protection, detoxification, immune system enhancement, connective tissue strengthening, and reduction of inflammation. PRO-C therefore provides outstanding nutritional support in a wide variety of conditions of poor health, as well as acts to support and maintain a state of health and well-being.

It the last several years the research results on Nrf2 activators have become well known and products developed that take advantage of these nutrients. For details see our blog article Natural Phytochemical Nrf2 Activators for Chemoprevention. Researchers have been studying specifically how enzyme-activating substances such as OPCs and anthocyans activate a transcription factor known as Nrf2 that causes the body to endogenously produce higher levels of a wide variety of protective enzymes including superoxide dismutase (SOD), catalase, and glutathione peroxidase.

Although we did not know about Nrf2 activators in 1997 when we formulated PRO-C, we have subsequently learned that four of the ingredients in the formula have powerful Nrf2 activity. These include grape seed extract, green tea extract, NAC, and r-lipoic acid. With this knowledge, we now understand that PRO-C provides both powerful external antioxidants (with extremely high ORAC5.0 values) that support redox cycles within the body, but also provides ingredients that allow the body to endogenously produce powerful protective enzymes for even greater free-radical protection and health.

PRO-C™ ANTIOXIDANT FORMULA INGREDIENTS

PRO-C contains buffered vitamin C (in the form of powdered calcium, magnesium, and zinc ascorbates), high-potency grape extract (from grape pulp, skins, and seeds), green tea extract (with>95% polyphenols and >45% EGCG), reduced glutathione, N-Acetyl-L-Cysteine (NAC), R-lipoic acid, coenzyme forms of vitamin B2 (R5P) and vitamin B6 (P5P), and selenium.

Below we will discuss each ingredient and show some of the research that confirms its effectiveness.

VITAMIN C

Vitamin C typically is called l-ascorbic acid or ascorbate and is an essential nutrient for humans and other animal species. The term “vitamin C” refers to a number of vitamins that have vitamin C activity in animals, including ascorbic acid and its salts (e.g., magnesium ascorbate, calcium ascorbate, sodium ascorbate, etc.), and some oxidized forms such as dehydroascorbate and semidehydroascorbate.

Vitamin C is known to perform many critical functions within the body involving detoxification, tissue building, immune enhancement, pain control, and controlling or killing pathogenic organisms. It is also known to be helpful for wound and bone healing, healthy skin and eyes, fighting infections, stress control, toxic exposure, and repairing damaged tissue of all types. For much more information on the many benefits of Vitamin C see our blog article Vitamin C – An Amazing Nutrient.

Below are two abstracts that show some of the beneficial effects of Vitamin C when used with other network antioxidants:

ABSTRACT 1:
Exhaustive physical exercise causes oxidation of glutathione status in blood: prevention by antioxidant administration.
Sastre J, Asensi M, Gasco E, Pallardo FV, Ferrero JA, Furukawa T, Vina J
In: Am J Physiol (1992 Nov) 263(5 Pt 2):R992-5

We have studied the effect of exhaustive concentric physical exercise on glutathione redox status and the possible relationship between blood glutathione oxidation and blood lactate and pyruvate levels. Levels of oxidized glutathione (GSSG) in blood increase after exhaustive concentric physical exercise in trained humans. GSSG levels were 72% higher immediately after exercise than at rest. They returned to normal values 1 h after exercise. Blood reduced glutathione (GSH) levels did not change significantly after the exercise. We have found a linear relationship between GSSG-to-GSH and lactate-to-pyruvate ratios in human blood before, during, and after exhaustive exercise. In rats, physical exercise also caused an increase in blood GSSG levels that were 200% higher after physical exercise than at rest. GSH levels did not change significantly. Thus, both in rats and humans, exhaustive physical exercise causes a change in glutathione redox status in blood. We have also found that antioxidant administration, i.e., oral vitamin C, N-acetyl-L- cysteine, or glutathione, is effective in preventing oxidation of the blood glutathione pool after physical exercise in rats.

ABSTRACT 2:
The effect of glutathione and vitamins A, C, and E on acute skin flap survival.

Hayden RE, Paniello RC, Yeung CS, Bello SL, Dawson SM
In: Laryngoscope (1987 Oct) 97(10):1176-9

Vitamins A, C, and E act as antioxidants and as free radical scavengers in biological systems. Glutathione is involved in several reactions in vitamin metabolism and also plays an important role in cell membrane protection against lipid peroxidation by free radicals. We sought to use these natural defense mechanisms against oxygen free radicals formed during reperfusion of ischemic skin flaps. An acute axial random skin flap model was utilized in the rat. Vitamins or glutathione were administered by oral gastric tube or intravenously in the perioperative period, and survival of the flap was measured at 1 week. Glutathione, beta-carotene, ascorbic acid and alpha-D- tocopherol showed mean flap survival of 84% to 89%, each of which was significantly improved over saline controls (67% p less than .0005). The mechanisms and biochemistry of these vitamins, and their interactions with other vitamins and with glutathione, are discussed, along with clinical implications of free radical scavenging and skin flap survival.

GRAPE EXTRACT

Grape extract (seeds, skin, pulp) contain highly bioavailable bioflavonoid complexes that in research studies have been shown to have powerful antioxidant capability. The Oligomeric Proanthocyanidins (OPCs) in grape seed extract are able to strengthen collagen fibers in aging or damaged connective tissue and can act as a preventative against connective tissue degradation.

Some research indicates that anthocyans, which are found in extracts of grape skin and stems (but not in grape seed extract), can reduce oxidized glutathione while at the same time become reduced themselves. In addition, extracts of grape skin and stems (but not those of grape seed extract) contain a material called trans-resveratrol that has been shown to have chemopreventive effects.

Below we have provided some of the abstracts that are included in our broad list of relevant abstracts for PRO-C.

ABSTRACT 3:
Protective effects of grape seed proanthocyanidins and selected antioxidants against TPA-induced hepatic and brain lipid peroxidation and DNA fragmentation, and peritoneal macrophage activation in mice.
Bagchi D, Garg A, Krohn RL, Bagchi M, Bagchi DJ, Balmoori J, Stohs SJ
In: Gen Pharmacol (1998 May) 30(5):771-6

1. The comparative protective abilities of a grape seed proanthocyanidin extract (GSPE) (25-100 mg/kg), vitamin C (100 mg/kg), vitamin E succinate (VES) (100 mg/kg) and beta-carotene (50 mg/kg) on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced lipid peroxidation and DNA fragmentation in the hepatic and brain tissues, as well as production of reactive oxygen species by peritoneal macrophages, were assessed. 2. Treatment of mice with GSPE (100 mg/kg), vitamin C, VES and beta-carotene decreased TPA-induced production of reactive oxygen species, as evidenced by decreases in the chemiluminescence response in peritoneal macrophages by approximately 70%, 18%, 47% and 16%, respectively, and cytochrome c reduction by approximately 65%, 15%, 37% and 19%, respectively, compared with controls. 3. GSPE, vitamin C, VES and beta-carotene decreased TPA-induced DNA fragmentation by approximately 47%, 10%, 30% and 11%, respectively, in the hepatic tissues, and 50%, 14%, 31% and 11%, respectively, in the brain tissues, at the doses that were used. Similar results were observed with respect to lipid peroxidation in hepatic mitochondria and microsomes and in brain homogenates. 4. GSPE exhibited a dose-dependent inhibition of TPA- induced lipid peroxidation and DNA fragmentation in liver and brain, as well as a dose-dependent inhibition of TPA-induced reactive oxygen species production in peritoneal macrophages. 5. GSPE and other antioxidants provided significant protection against TPA-induced oxidative damage, with GSPE providing better protection than did other antioxidants at the doses that were employed.

ABSTRACT 4:
Clinical and capillaroscopic evaluation of chronic uncomplicated venous insufficiency with procyanidins extracted from vitis vinifera
Costantini A, De Bernardi T, Gotti A
In: Minerva Cardioangiol (1999 Jan-Feb) 47(1-2):39-46

BACKGROUND: The pharmacological treatment of non-complicated chronic venous insufficiency is a current and well-debated topic. The introduction of new products with action on the venous system, improved knowledge on the physiopathology of venous insufficiency and the possibility provided by new analytical instruments, have given new impulse to the consolidation of the clinical value of phlebotonics in this indication. METHODS: In light of this, 24 patients with non-complicated chronic venous insufficiency were treated with oral administration of Oligomeric Proanthocyanidins (Pycnogenols-OPC) 100 mg/day. To evaluate the therapeutic efficacy of the treatment, an instrumental evaluation by optical probe capillaroscope was employed in addition to the traditional subjective clinical parameters: swelling, itching, heaviness and pain. The videocapillaroscope examination was performed at the lower third of the leg and the first toe. Edema in the capillaroscopic field, the number of observable capillaries and the capillary dilatation were the parameter chosen to evaluate the efficacy of treatment. All patients completed the study with no reports of adverse events during the period of observation. RESULTS: The results obtained show a positive clinical response (improved or absent symptoms) in over 80% of patients, with significant improvement of symptoms already evident after the first 10 days of treatment. The mechanism of action of the OPCs explains the rapid reduction of the swelling of the lower limbs and correlated with this are the other evaluable symptoms: heaviness and itching. Particularly striking results were observed for itching and pain which completely disappeared during the course of therapy in 80% and 53% of the patients respectively. Noteworthy is the good correlation between the clinical and instrumental data, with improvement in a total of 70% of patients. CONCLUSIONS: The results obtained in the course of this clinical experience, with evident improvement already during the first weeks of treatment, the absence of adverse events added to the benefit of a once-a-day administration, justify the use of OPC in the treatment of non-complicated chronic venous insufficiency.

ABSTRACT 5:
Polymeric procyanidin fraction from defatted grape seeds protects HepG2 cells against oxidative stress by inducing phase II enzymes via Nrf2 activation.
Younghwa Kim, Youngmin Choi, Hyeonmi Ham, Heon-Sang Jeong, Junsoo Lee
Kim, Y., Choi, Y., Ham, H. et al. Food Sci Biotechnol (2013) 22: 485. https://doi.org/10.1007/s10068-013-0105-x

Nuclear factor erythroid 2-related factor 2 (Nrf2) is an important transcription factor that regulates antioxidant response element (ARE)-driven phase II detoxification enzymes. In this study, induction of phase II enzymes via Nrf2/ARE activation in the cytoprotective effect of crude polyphenol extract (CPE), oligomeric procyanidin fraction (OPF), and polymeric procyanidin fraction (PPF) from defatted grape seeds in HepG2 cells was evaluated. Among these treatments, the treatment with PPF significantly increased Nrf2 protein expression in the nuclear fraction. Treating the samples increased heme oxygenase-1 (HO-1) and NAD(P)H:quinone oxidoreductase 1 (NQO1) protein expression in a dose-dependent manner, and PPF significantly increased the levels of phase II enzymes. Cellular generation of reactive oxygen species (ROS) were effectively reduced by PPF. These results suggest that pretreatment with PPF shows a cytoprotective effect by inhibiting ROS production and inducing HO-1 and NQO1 expression via Nrf2 activation in HepG2 cells.

GREEN TEA EXTRACT

Green tea extract is obtained from the unfermented leaves of Camellia sinensis for which numerous biological activities have been reported including: antimutagenic, antibacterial, hypocholesterolemic, antioxidant, and protective against tumorigenesis. Below we have selected a few of the many abstracts we have on file showing the benefit of green tea extract.

Green tea antioxidant polyphenols catechins

Green tea leaves are high in antioxidant polyphenols and catechins.

ABSTRACT 6:
Enhancement of antioxidant and phase II enzymes by oral feeding of green tea polyphenols in drinking water to SKH-1 hairless mice: possible role in cancer chemoprevention.
Khan SG, Katiyar SK, Agarwal R, Mukhtar H
In: Cancer Res (1992 Jul 15) 52(14):4050-2

Following the oral feeding of a polyphenolic fraction isolated from green tea (GTP) in drinking water, an increase in the activities of antioxidant and phase II enzymes in skin, small bowel, liver, and lung of female SKH-1 hairless mice was observed. GTP feeding (0.2%, w/v) to mice for 30 days significantly increased the activities of glutathione peroxidase, catalase, and quinone reductase in small bowel, liver, and lungs, and glutathione S-transferase in small bowel and liver. GTP feeding to mice also resulted in considerable enhancement of glutathione reductase activity in liver. In general, the increase in antioxidant and phase II enzyme activities was more pronounced in lung and small bowel as compared to liver and skin. The significance of these results can be implicated in relation to the cancer chemopreventive effects of GTP against the induction of tumors in various target organs.

ABSTRACT 7:
INHIBITORY EFFECT OF SIX GREEN TEA CATECHINS AND CAFFEINE ON THE GROWTH OF FOUR SELECTED HUMAN TUMOR CELL LINES.
In: Anticancer Drugs (1996 Jun) 7(4):461-8
Institutional address: Department of Pharmacology and Toxicology College of Pharmacy University of Arizona Tucson 85721 USA.

Green tea is an aqueous infusion of dried unfermented leaves of Camellia sinensis (family Theaceae) from which numerous biological activities have been reported including antimutagenic, antibacterial, hypocholesterolemic, antioxidant, antitumor and cancer preventive activities. From the aqueous-alcoholic extract of green tea leaves, six compounds (+)-gallocatechin (GC), (-)-epicatechin (EC), (-)- epigallocatechin (EGC), (-)-epicatechin gallate (ECG), (-)- epigallocatechin gallate (EGCG) and caffeine, were isolated and purified. Together with (+)-catechin, these compounds were tested against each of four human tumor cells lines (MCF-7 breast carcinoma, HT-29 colon carcinoma, A-427 lung carcinoma and UACC-375 melanoma). The three most potent green tea components against all four tumor cell lines were EGCG, GC and EGC. EGCG was the most potent of the seven green tea components against three out of the four cell lines (i.e. MCF-7 breast cancer, HT-29 colon cancer and UACC-375 melanoma). On the basis of these extensive in vitro studies, it would be of considerable interest to evaluate all three of these components in comparative preclinical in vivo animal tumor model systems before final decisions are made concerning which of these potential chemopreventive drugs should be taken into broad clinical trials.

GLUTATHIONE AND N-ACETYL-L-CYSTEINE (NAC)

Glutathione and NAC (a major precursor of glutathione) both provide important protection against toxins and free radicals, and can strengthen the immune system. Glutathione is considered to be one of the most important protective substances in the human body with almost 60% of liver detoxification accounted for by this key substance. In addition, glutathione is one of the most potent anti-viral substances known.

Some research has indicated that glutathione may not be able to enter easily into certain types of cells, but NAC is able to enter these cells and be converted into glutathione once inside the cell. Thus, the combination of glutathione and NAC appear to be more potent than either alone.

Below we provide some of the key abstracts we have on file regarding NAC and glutathione.

ABSTRACT 8
GSH rescue by N-acetylcysteine.
Ruffmann R Wendel A
In: Klin Wochenschr (1991 Nov 15) 69(18):857-62

Reduced glutathione (GSH) is the main intracellular low molecular weight thiol. GSH acts as a nucleophilic scavenger and as an enzyme-catalyzed antioxidant in the event of electrophilic/oxidative tissue injury. Therefore, GSH has a major role as a protector of biological structures and functions. GSH depletion has been recognized as a hazardous condition during paracetamol intoxication. Conversely, GSH rescue, meaning recovery of the protective potential of GSH by early administration of N-acetylcysteine (NAC), has been found to be life-saving. Lack of GSH and electrophilic/oxidative injury have been identified among the causes of the adult respiratory distress syndrome (ARDS), idiopathic pulmonary fibrosis (IPF), and the acquired immunodeficiency syndrome (AIDS). Experimental and early clinical data (in ARDS) point to the role of NAC in the treatment of these conditions. Recently, orally given NAC has been shown to enhance the levels of GSH in the liver, in plasma, and notably in the bronchoalveolar lavage fluid. Rescue of GSH through NAC needs to be appreciated as an independent treatment modality for an array of different disease, all of which have one feature in common: pathogenetically relevant loss of GSH.

ABSTRACT 9
Cysteine and glutathione concentrations in plasma and bronchoalveolar lavage fluid after treatment with N-acetylcysteine.
Bridgeman MM Marsden M MacNee W Flenley DC Ryle AP
In: Thorax (1991 Jan) 46(1):39-42

N-acetylcysteine (600 mg/day) was given to patients by mouth for five days before bronchoscopy and bronchoalveolar lavage to determine whether N-acetylcysteine could increase the concentrations of the antioxidant reduced glutathione in plasma and bronchoalveolar lavage fluid. Bronchoalveolar lavage was performed 1-3 hours (group 2, n = 9) and 16-20 hours (group 3, n = 10) after the last dose of N-acetylcysteine and the values were compared with those in a control group receiving no N-acetylcysteine (group 1, n = 8). N-Acetylcysteine was not detected in plasma or lavage fluid. Plasma concentrations of cysteine, the main metabolite of N-acetylcysteine and a precursor of reduced glutathione, were greater in the groups receiving treatment (groups 2 and 3) than in group 1. Cysteine concentrations in lavage fluid were similar in the three groups. Concentrations of reduced glutathione were greater in both plasma and lavage fluid in group 2 than in group 1. These data suggest that N-acetylcysteine given by mouth is rapidly deacetylated to cysteine, with resulting increases in the concentrations of cysteine in plasma and of reduced glutathione in plasma and the airways, which thus temporarily increase the antioxidant capacity of the lung.

R-LIPOIC ACID / ALPHA-LIPOIC ACID

R-Lipoic Acid is normally made at low levels in the human body, where it functions primarily as an important metabolic nutrient in the conversion of pyruvic acid into acetyl coenzyme A. As such, it plays a crucial role in the metabolism of both fats and carbohydrates into energy. In addition, r-lipoic acid functions as an extremely powerful antioxidant capable of trapping many different types of free radicals in the body.

Because it is both water and fat soluble, lipoic acid is able to operate in a broader range of body tissues than most other antioxidants. Its small size allows lipoic acid to enter areas of the body not easily accessible to many other substances; this allows lipoic acid, for example, to enter the cell nucleus and prevent free-radical damage to DNA.

Because it is such a powerful antioxidant and can easily function as such in both a reduced and oxidized state, lipoic acid is able to protect other important antioxidants such as glutathione, Vitamin E, and Vitamin C. R-lipoic acid is also able to chelate heavy metals such as lead, cadmium, mercury, free iron, and free copper out of the body.

Below we provide relevant scientific abstracts from our database regarding R-Lipoic acid.

ABSTRACT 10:
Alpha-Lipoic acid as a biological antioxidant.
Packer L Witt EH Tritschler HJ
In: Free Radic Biol Med (1995 Aug) 19(2):227-50

alpha-Lipoic acid, which plays an essential role in mitochondrial dehydrogenase reactions, has recently gained considerable attention as an antioxidant. Lipoate, or its reduced form, dihydrolipoate, reacts with reactive oxygen species such as superoxide radicals, hydroxyl radicals, hypochlorous acid, peroxyl radicals, and singlet oxygen. It also protects membranes by interacting with vitamin C and glutathione, which may in turn recycle vitamin E. In addition to its antioxidant activities, dihydrolipoate may exert prooxidant actions through reduction of iron. alpha-Lipoic acid administration has been shown to be beneficial in a number of oxidative stress models such as ischemia-reperfusion injury, diabetes (both alpha-lipoic acid and dihydrolipoic acid exhibit hydrophobic binding to proteins such as albumin, which can prevent glycation reactions), cataract formation, HIV activation, neurodegeneration, and radiation injury. Furthermore, lipoate can function as a redox regulator of proteins such as myoglobin, prolactin, thioredoxin and NF-kappa B transcription factor. We review the properties of lipoate in terms of (1) reactions with reactive oxygen species; (2) interactions with other antioxidants; (3) beneficial effects in oxidative stress models or clinical conditions.

ABSTRACT 11:
Regeneration of glutathione by α-lipoic acid via Nrf2/ARE signaling pathway alleviates cadmium-induced HepG2 cell toxicity.
Zhang J, Zhou X, Wu W, Wang J, Xie H, Wu Z.
In: Environ Toxicol Pharmacol. 2017 Apr;51:30-37. doi: 10.1016/j.etap.2017.02.022. Epub 2017 Feb 27.

Alpha-lipoic acid (α-LA) is an important antioxidant that is capable of regenerating other antioxidants, such as glutathione (GSH). However, the underlying molecular mechanism by which α-LA regenerates GSH remains poorly understood. The current study aimed to investigate whether α-LA regenerates GSH by activation of Nrf2 to alleviate cadmium-induced cytotoxicity in HepG2 cells. In the present study, we found that cadmium induced cell death by depletion of GSH through inactivation of Nrf2. Addition of α-LA to cadmium-treated cells reactivated Nrf2 and regenerated GSH through elevating the Nrf2-downstream genes γ-glutamate-cysteine ligase (γ-GCL) and GR, both of which are key enzymes for GSH synthesis. However, blocking Nrf2 with brusatol in the cells co-treated with α-LA and cadmium reduced the mRNA and the protein levels of γ-GCL and GR, thus suppressed GSH regeneration by α-LA. Our results indicated that α-LA activated Nrf2 signaling pathway, which upregulated the transcription of the enzymes for GSH synthesis and therefore GSH contents to alleviate cadmium-induced cytotoxicity in HepG2 cells.

SELENIUM

Selenium has been shown by clinical research to be a key mineral in the body’s defenses against free radicals and has been shown to be a major factor in reducing the symptoms of HIV infections and in the prevention of tumors. Selenium is used in conjunction with glutathione to form the powerful enzyme glutathione peroxidase that is responsible for detoxification of peroxides formed during the process of aerobic metabolism in humans and other animals.

ABSTRACT 12
Serum selenium concentrations in rheumatoid arthritis.
In: Ann Rheum Dis (1991 Jun) 50(6):376-8

O’Dell JR, Lemley-Gillespie S, Palmer WR, Weaver AL, Moore GF, Klassen LW

Selenium is a trace element and an essential part of the enzyme glutathione peroxidase, which protects cells from oxidative damage. Selenium has been shown to have antiproliferative, anti-inflammatory, antiviral, and immune altering effects. Serum selenium concentrations in 101 patients with seropositive rheumatoid arthritis were found to be significantly lower than those in 29 normal, healthy controls (mean (SD) 148 (42) v 160 (25) micrograms/l) and also lower than those in eight patients with fibrositis (148 (42) v 166 (25) micrograms/l). It is speculated that serum selenium concentrations may modulate the effect of viral or other infections in subjects with the appropriate genetic background and in this way enhance the development or progression of rheumatoid arthritis.

ABSTRACT 13
Studies on selenium in top athletes.
Dragan I, Ploesteanu E, Cristea E, Mohora M, Dinu V, Troescu VS
In: Physiologie (1988 Oct-Dec) 25(4):187-90

The authors performed a controlled trial in 18 top athletes (9 weight lifters and 9 rowers, girls) in order to make evident some chronic and acute effects (antioxidant) of selenium. Nonprotein–SH (essential glutathione), lipid peroxides (MDA-malondialdehyde), glucose-6-phosphate dehydrogenases (G-6-PDH) and fructose-1,6- diphosphate aldolase in serum, have been recorded initially on basal conditions, after 3 weeks of treatment (100 micrograms/day selenium or placebo) and again after 3 weeks of treatment, also on basal conditions, when crossing over the groups (between a free interval of 10 days). In another trial we registered these parameters on basal conditions and after two hours of hard training accompanied by a per oral administration of 150 micrograms selenium (respectively placebo). The results show significant changes under selenium treatment of the peroxides, G-6-PDH and light changes, not significant of the nonprotein–SH, changes which could suggest an antioxidant effect of this element.

VITAMINS B2 and B6 IN COENZYME FORMS

Vitamin B2 as coenzyme riboflavin-5-phosphate is a key vitamin that supports the regeneration of glutathione (via glutathione reductase). Vitamin B6 as coenzyme pyridoxal-5-phosphate is a key vitamin that supports the ability of glutathione to combine with toxic substances (via glutathione transferase) in the process of eliminating them from the body. They are especially effective in their coenzyme forms which allows them to be directly utilized by the body starting in the intestinal tract.

MAGNESIUM, CALCIUM, AND ZINC

Magnesium, zinc, and calcium synergistically work with (and enhance the effects of) the other ingredients in PRO-C. Minerals are especially needed as active components of enzymes that drive metabolic activity. For example, magnesium is required in the functioning of more than 325 types of enzymes.

PRO-C™ SUPER ANTIOXIDANT FORMULA BENEFITS

HIGHLY EFFECTIVE VITAMIN C FORMULA PLUS ANTIOXIDANTS. A complete vitamin C formula, a powerful antioxidant Formula, and Nrf2 activator combined in a single advanced supplement!

POWERFUL, SYNERGISTIC FREE-RADICAL QUENCHING FORMULA. PRO-C™ components work together to quench free radicals in your body. Vitamin C enables grape seed extract to function more effectively, and conversely grape seed extract potentiates vitamin C. Green tea extract boosts ORAC (Oxygen Radical Absorbance Capacity) value.

PROVIDES SIGNIFICANT AMOUNTS OF POWERFUL NRF2 ACTIVATORS (from Grape Extract, Green Tea Extract, NAC, and R-Lipoic Acid) that stimulate the production of the body’s own protective antioxidants including superoxide dismutase, catalase, glutathione peroxidase, and heme oxygenase.

SUPERIOR, BUFFERED (NON-ACIDIC) FORM OF VITAMIN C. Mineral Ascorbates never acidify your body, keeping you pH balanced. Staying alkaline is an important element in maintaining a healthy body.

RAPID ASSIMILATION. Capsule form ensures rapid uptake and assimilation in the body. You may also empty capsule contents into water, food, or directly Into mouth, if desired. Good, mildly tart taste!

COMPOSITION OF PRO-C™ SUPER ANTIOXIDANT FORMULA

One (1) vegetarian capsule of PRO-C provides the following percentages of the Daily Value:

NUTRIENT AMOUNT % Daily Value
Vitamin C (from mineral ascorbates) 500 mg 833%
BioVin® Grape Extract 30 mg *
Green Tea Extract 30 mg *
Calcium (from calcium ascorbate) 23 mg 2.3%
Magnesium (from magnesium ascorbate) 23 mg 5.7%
L-Glutathione (reduced) 20 mg *
N-Acetyl-L-Cysteine (NAC) 15 mg *
R-Lipoic Acid 5 mg *
Zinc (from zinc ascorbate) 2 mg 13%
Vitamin B2 (from riboflavin-5′-phosphate) 1 mg 118%
Vitamin B6 (from pyridoxal-5′-phosphate) 1 mg 50%
Selenium (from l-selenomethionine) 10 mcg *

* No established Daily Value

DIRECTIONS: As a dietary supplement take 1–3 capsules or more daily in divided doses (i.e., spread out over the day), or as recommended by a health care professional. It initially may be useful to take up to 6 capsules per day in divided doses for one week. The contents of the capsule may be emptied into juice or food, as needed.

INGREDIENTS: PRO-C™ SUPER ANTIOXIDANT FORMULA contains only the highest-quality USP grade magnesium ascorbate, USP grade calcium ascorbate, BioVin® grape extract (greater than 75% polyphenols, 55% OPC, greater than 3.5% anthocyanidins from grape pulp, skins, and seeds, and a small amount of trans resveratrol), green tea extract (95% min. polyphenols and 45% min. EGCG), l-glutathione (reduced), USP grade n-acetyl-l-cysteine, USP grade zinc ascorbate, r-(+)-lipoic acid, riboflavin-5′-phosphate, pyridoxal-5′-phosphate, l-selenomethionine, the smallest amounts of microcrystalline cellulose and silica in a vegetarian capsule.

PRO-C™ does not contain wheat, rye, oats, corn antigen, barley, gluten, soy, egg, dairy, yeast, sugar, sulfates, phosphates (other than coenzyme forms), fats, chlorides, GMOs, wax, preservatives, colorings, or artificial flavorings.

Click here to order PRO-C™.

SOURCES & RESOURCES

BOOKS

The Antioxidant Miracle. Lester Packer, PhD, and Carol Coleman. New York: John Wiley and Sons, 1999.

How to Live Longer and Feel Better. Dr. Linus Pauling. Corvallis, OR: Oregon State University Press, 2006.

ARTICLES

Review of Scientific Research on Oligomeric Proanthocyanidins (OPC)” (rev. 2017) by Hank Liers, PhD

“Vitamin C – An Amazing Nutrient” by Hank Liers, PhD

PRO-C™ and Ultimate Protector™ – Comparison by Hank Liers, PhD

“Antioxidant Cocktail Update: Part 1: The Take Home Message is to Use Antioxidant Supplements”
(An interview of Dr. Lester Packer by Richard A. Passwater, PhD, Whole Foods Magazine 1999)

ABSTRACTS

PRO-C™ / Vitamin C Abstracts

Catechin Abstracts

N-Acetyl-L-Cysteine (NAC) Abstracts

Lipoic Acid Abstracts

WEBSITES

Orthomolecular.org
(Therapeutic Nutrition Based Upon Biochemical Individuality)

PRODUCTS

PRO-C™Super Antioxidant Formula

Ultimate Protector™Nrf2 Activator Formula

OPC-C™

HPDI Vitamin C Products

2

THE NEED FOR IODINE SUPPLEMENTATION

Dr. Hank Liers PhD iodine supplementationFred Liers PhD iodine supplementationThe Orthomolecular Medicine News Service (OMNS) published on June 12 “The Need for Iodine Supplementation.” We believe strongly in the need for iodine supplementation, especially given the fact that more than 90% of the US population is iodine deficient. For this reason we make available both Nascent Iodine and Lugol’s Iodine Solution 2 to our customers.

We present the full OMNS article (below), as a source of valuable information to our resellers and Creating Health Naturally readers. The factors contributing to massive-scale iodine deficiency remain virtually unchanged over decades. This has led to a greater need for educating health professionals and individuals about the critical importance of iodine supplementation.

Another useful article discussing the benefits of iodine supplementation was published August 2 by Dr. Mark Sircus, OMD: “Iodine, Thyroid and Low Body Temperature.” ~

The Need for Iodine Supplementation

by Wojciech Rychlik, PhD

(OMNS, June 12, 2017) Feeling tired, having low energy or depression, gaining weight, memory problems, having dry skin, dry mouth, or immune system issues? There is good chance your body needs iodine supplementation. Why iodine? Because this essential to human health element has been singled out as dangerous, for several obscure reasons, and it has been gradually eliminated from our diet, and even worse, replaced by its antagonist, bromine. This trend has been termed, iodophobia (1). It is a cause of widely occurring hypothyroidism in many developed countries.

Iodine: How Much?

Iodine deficiency is associated with (2, 3, 4):

  • Fibrocystic breast disease leading to breast cancer and stomach cancer
  • Goiter (enlarged thyroid)
  • Mental issues from reduced alertness, lowered IQ, autism to cretinism, lack of iodine for the fetus leads to cretinism, and in milder cases to autism and ADHD
  • Slow metabolism, leading to tiredness, sluggishness, fatigue, apathy, depression, and insomnia
  • Inability to produce saliva, dry skin, and lack of sweating
  • Lack of optimal detoxification, especially of bromides, fluorides, and heavy metals
  • Sensitivity to temperature changes, and cold hands and feet
  • Muscle pain, fibrosis, and fibromyalgia
  • Erectile dysfunction, infertility and miscarriages, and low sex drive
  • Overweight
  • High blood pressure, and increased incidence of heart attacks and strokes

The Food and Agriculture Organization (FAO) of the United Nations has published probable safe upper limits for dietary intake of iodine (5). They range from 150 micrograms (mcg) per kilogram (kg) per day in newborn infants to 30mcg/kg/day in adults. That is 2 milligrams (2,000 micrograms) daily for a 146-pound adult. The safe upper limit is higher during pregnancy and lactation (40 mcg/kg/day).

Treatments for Hypothyroidism

The simplest method to deal with an underactive thyroid is proper supplementation with iodine, called orthoiodosupplementation. If the thyroid is damaged, then supplementation with thyroid hormones, thyroxine (T4) and triiodothyronine (T3, the main biologically active hormone) may be necessary. Supplementation (6). with these hormones should be done under close supervision of a medical professional. However, supplementation with inorganic iodine is generally much safer, as the body “knows” how much T4 and T3 need to make. There are also drugs that change physiology of iodine metabolism, but this subject is beyond the scope of this article. Pharmaceutical companies pressure doctors to avoid inexpensive orthoiodosupplementation, so you won’t likely get a prescription for inexpensive Lugol’s solution from a mainstream practitioner.

One caveat to supplementation with iodine is the autoimmune illness called Hashimoto’s disease, or chronic lymphocytic thyroiditis, which is one of the potential causes of hypothyroidism. Unfortunately, when hypothyroidism is diagnosed, the possibility that Hashimoto’s disease underlies this condition has not always been properly tested. Therefore, Hashimoto’s disease has often been misdiagnosed. Doctors usually treat this condition with hormone replacement therapy, and some believe that excessive iodine intake may trigger it in susceptible people (7). Always ask your doctor if iodine supplements are right for you.

History of Iodine Usage and “Iodophobia”

This subject has been covered in detail by Dr. Guy E. Abraham (8,9,10). The iodine element was discovered in 1811 by B. Courtois. In 1850–1853 A. Chatin noted that goiter and cretinism are rare in geological zones rich in iodine and frequent where iodine is in short supply, and that goiter can be prevented by iodine supplementation. In 1895 E. Baumann proposed that iodine is the active element in the thyroid gland.

By the time Bauman identified large concentrations of iodine in the thyroid gland in 1895, pharmaceutical and apothecary preparations containing iodine, excluding thyroid extracts, were widely used as a panacea.

To quote Kelley: (11) “The variety of diseases for which iodine was prescribed in the early years is astonishing – paralysis, chorea, scrofula, lacrimal fistula, deafness, distortions of the spine, hip-joint disease, syphilis, acute inflammation, gout, gangrene, dropsy, carbuncles, whitlow, chilblains, burns, scalds, lupus, croup, catarrh, asthma, ulcers, and bronchitis – to mention only a few. Indeed, tincture of iodine, iodoform, or one of the iodides, was applied to almost every case that resisted the ordinary routine of practice; and between 1820 and 1840 there appeared a remarkable series of essays and monographs testifying to the extraordinary benefits to be achieved by this new and potent remedy.”

Unfortunately, these monographs have virtually disappeared from US medical libraries. In the mid-1800s, iodine treatments of some diseases called for ingestion of gram (1,000 mg) amounts per day. However, most treatments were from 5 to 50 mg daily. The recommended daily amount of iodine by Dr. G. E. Abraham is 0.1-0.3 ml Lugol containing 12.5-37.5 mg elemental iodine. This is the amount of iodine needed for whole body sufficiency, based on a recently reported iodine/iodide-loading test (12). Thyroid gland sufficiency for iodide is achieved with a lower dose.

Lugol's iodine supplementation

The first iodophobic authority emerged in early 1900s. Prof. T. Kochler reported that he suffered from overactive thyroid following ingestion of iodide (just a single individual case, not a statistical research study!) Despite this, the number of applications grew. In an International Index published in 1956, and devoted exclusively to iodine pharmaceuticals, no less than 1,700 approved iodine-containing products were listed. In 1948 Wolff and Chaikoff published that a serum inorganic iodide level at a concentration of 1 µM blocks (one micromolar) the synthesis of thyroid hormones, resulting in hypothyroidism and goiter in rats. But this conclusion was erroneous as they even did not measure thyroid hormones in the rats studied, and of course, hypothyroidism and goiter were not observed in those rats. Many organic forms of iodinated drugs were quite poisonous. Unfortunately, medical establishment did not make a distinction between organic and inorganic forms of iodine, and iodophobia became more popular.

Decades ago, iodine was added to bread so that one slice contained 150 mcg of iodine (the current recommended daily allowance). In the 1980s, bromine replaced iodine in bread. Since bromide is an antagonist to iodine (it is goitrogenic), it worsened iodine deficiency in the US. Moreover, a big push to remove salt from our diet (the only grocery item still supplemented with iodine) exacerbated the problem. The only developed nation that resisted iodophobia is Japan, statistically the healthiest and longest living nation on the planet. Their average daily consumption of iodine is around 5 mg, with various reports ranging from 1 mg to 18 mg. In a study of reported daily iodine intake versus total number of clinical symptoms, an intake of approximately 1 mg per day correlated with the lowest number of reported symptoms, that is, the highest level of health (13). Recent popularization of bromides in our food supplies likely increased this amount.

According to Dr. Abraham, (14) “proper amounts of iodine in the food supply should be considered one of a nation’s greatest assets. Removing iodine from the food supply is a major mistake. Supplying a daily intake of iodine sufficient for the whole body (100-400 times the RDA) gives protection against goitrogens and radioactive iodine/iodide fallout; improves immune functions, resulting in an adequate defense system against infection; decreases singlet oxygen formation which is the major cause of oxidative damage to DNA and macromolecules, resulting in an anticarcinogenic effect in every organ; results in a detoxifying effect by increasing urinary excretion of the toxic metals lead, mercury, cadmium, and aluminum, as well as the goitrogens fluoride and bromide; normalizes hormone receptor functions resulting in improved response to thyroid hormones both endogenous and exogenous; and results in better control of blood sugar in diabetic patients; stabilizes cardiac rhythm, obviating the need for the toxic sustained release form of iodine, amiodarone; and normalizes blood pressure without medication in hypertensive patients. Iodine deficiency is the major cause of cognitive impairment, worldwide.”

The Iodine-Cancer Connection

The body requires iodine to metabolize both omega-3 and omega-6 fatty acids. A substance called delta-iodolactone, a derivative of arachidonic acid, which is produced in the thyroid gland and breast tissue, prostate, colon, and the nervous system, is a regulator of a process called cellular apoptosis (“cell death”). Ascorbic acid is required to stimulate intracellular hydrogen peroxide synthesis that, in turn, provides the energy to make iodine free radicals necessary for this reaction. When the level of delta-iodolactone is high enough, the process of apoptosis can then kill cancer cells. (15)

Unfortunately, the recommended daily allowance (RDA) for iodine — about 150 mcg per day — will not allow delta-iodolactone to be efficiently formed in the thyroid gland. The thyroid requires higher iodine concentrations to efficiently produce it. Researchers have found that 100 times the RDA amount of iodine is optimal to produce delta-iodolactone. That equates to taking about 15 mg of iodine per day (15,16). These findings are important because they imply that there are some biochemical reactions that require much larger amounts of iodine than the current RDA. The mechanism by which delta-iodolactone induces cell death may be an important pathway for curing some types of cancer.

Forms of Iodine

Inorganic iodine exists in 6 oxidative states, from -1 to +7. The most reduced form (with most electrons) is iodide (I); an example is potassium iodide. The diatomic form of elemental iodine I2, has no electrical charge. Monoatomic iodine also has no electrical charge, but is unstable and highly reactive (free radical, labeled as an I with a dot, I* ). It can be produced by exposing I2 to ultraviolet light. Electric and magnetic fields won’t do it, as is sometimes incorrectly suggested. More oxidized forms of iodine are: hypoiodite (I+1), iodite (I+3), iodate (I+5), and periodate (I+7). The body’s metabolism may convert (reduce) these forms to biochemically available iodide, but at the cost of depleting its antioxidants. All forms of positively charged iodine are relatively poisonous, with established lethal doses (LD50) in the range of 35 to 2100 mg/kg. Elemental iodine (I2) and iodides (I) are non-poisonous. However, a bad “antiseptic” non-culinary taste of iodine (I2) suggests to our senses that this is not so good choice for supplementation.Nascent iodine supplementation

Despite that adverse taste, almost all the research on iodine supplementation has been done using Lugol’s Solution (17). The original solution is called 5% Lugol’s Iodine, but in reality it consists of 12.5% iodide/iodine or (I/[I3]) ions. Two drops of Lugol’s Solution (0.1 ml) contain 12.5 mg iodine/iodide mix. Iodine tablets that are a solid form of Lugol’s solution, were created to mask the taste and make the doses more precise for dietary supplementation.

I should mention a few points about Edgar Cayce’s atomidine. This famous visionary wrote several articles about the best form of iodine supplement (18). Some claim that this was iodine trichloride, but that cannot be true as this compound is toxic by ingestion and damaging to mucous membranes. It decomposes to ICl and poisonous gas Cl2 at 77 degrees C and also in water at room temperature (19). Most likely Cayce’s atomidine was simply a 1% iodine solution (I2) in 95% ethanol. I am surprised that there are educated people, even medical doctors who claim that “elemental monoatomic iodine” preparations (Atomidine, Nascent Iodine etc.) are the best forms of iodine supplements. May be it has something to do with efficient marketing? Elemental Iodine (I2) is soluble in glycerin. Replacement of ethanol with glycerol indeed makes these supplements more consumption-friendly, so they are sold by some vendors as superior products to Cayce’s ethanol-formulated one. Personally, I think glycerol-based I2 supplements are inferior to iodides; however, they are excellent antiseptics.

To defend the validity of Cayce’s vision, in thyroid, I ion and amino acid tyrosine react through a short intermediate step by forming monoatomic I* free radical (selenium and hydrogen peroxide are involved) to make monoiodotyrosine. Diiodotyrosine is formed analogical way, and finally, two of these molecules combine to produce thyroxine. All those steps are carried by the enzyme thyroid peroxidase, which is normally attached to the protein thyroglobulin. So, yes, monoatomic iodine I* exists in human bodies, and it directly reacts with tyrosine, but no, it wouldn’t be healthy to consume iodine free radicals as their high reactivity would prevent safe transport throughout the body.

In the mid-1930s the thyroid hormone thyroxine became available on the market. This was a blessing for people who had damaged their thyroid. Unfortunately, doctors started to prescribe this hormone to just about anybody with hypothyroidism, thinking that they can control better thyroid hormone levels than our bodies can. And, the “iodine is iodine, no matter what form” mentality became a dangerous trend, because most medical professionals do not fully appreciate the difference between the raw nutrient (iodine) and its product (hormone).

The pharmaceutical industry came up with lots of organic forms of iodine (NB: organic, meaning that iodine is bound to a carbon-atom-containing molecule and NOT meaning it’s grown in a pesticide-free environment), all relatively toxic and certainly not to be used without strict medical supervision. Only inorganic forms of iodine, I and I2, are safe for supplementation (20,21). Further, high doses of these supplements should still be supervised by your doctor.

Iodine Uses

Iodine plays critical role in human metabolism. Many researchers believe the RDA value of 150 mcg for iodine is too low, especially when this element is commonly substituted with competing element bromine. Therefore, the main use of iodine in dietary supplementation is to enable optimal thyroid function. There are a number of medical conditions where iodine is either essential or helpful. For best results, iodine/iodide should be supplemented with selenium, magnesium, copper (there is usually enough of it in tap water as copper is widely used in plumbing), vitamin B2 (riboflavin) and B3 (niacin). Ask your doctor before taking any iodine supplements, especially if you are on medications.

Elemental iodine (I2) is antibacterial and antifungal, so iodine or iodine/iodide solutions are commonly used topically to sterilize wounds, or internally to fight infections, such as vaginitis and sore throat, and also to sanitize drinking water. Because iodine is antibacterial, drinking it may cause friendly bacterial flora to suffer and result in diarrhea and stomach cramps (the same applies to Lugol’s solution, but to a lesser extent as it contains iodides as well).

Ingestion of iodides prevents the incorporation of destructive radioactive iodine into the body (mainly by the thyroid) in case of nuclear accidents. It also may help flushing already incorporated radioactive iodine from the thyroid, although too much iodine inhibits secretion of T4/T3 from the gland.

Common-Sense Cautions

Overdosing any of the iodine supplements can lead to swollen salivary glands, metallic aftertaste and skin rash and itching (that are usually due to rapid process of detoxification from heavy metals fluorides and bromides), faster heartbeat or palpitations and diarrhea. When supplementation is stopped, these symptoms will usually disappear quickly, often within one day. Iodine stabilizes thyroid hormone production, so it is an adaptogen, but in rare cases, such as acquired allergy to iodine (Hashimoto’s disease), it may actually misbalance it. In some cases, iodine supplementation can cause hypothyroidism, so it’s important to get checked by your doctor to make sure that your thyroid function is not worsened by supplementation. Some authors advising caution are Alan Christianson (22), Jeffrey Dach, (23) and Alan Gaby (24). Testing of levels of thyroid hormones along with testing and supplementation of mineral nutrients such as selenium, zinc, copper, magnesium calcium, and other trace minerals may prevent problems in cases where high doses of iodine/iodide might tend to cause Hashimoto’s disease. (23)

Inorganic Iodine Availability

The most common form of iodine supplement is Lugol’s solution (17). The original solution contains 5% of iodine and 10% iodide. Solid pill forms of Lugol’s solution are sold under several brand names. Potassium iodide (KI), my favorite iodine supplement, is available as tablets as well. Various products with kelp or other seaweed extracts contain iodides as well. Check the label when you buy as some of them are very diluted.

It is difficult to find inexpensive elemental iodine (I2) solution in alcohol. You can buy iodine crystals online and make the proper solution by yourself very easily (using either alcohol or glycerol). The monoatomic iodine concept is simply a marketing gimmick that has been created to inflate the price several fold. Note that if the monoatomic claims were really true, few would really want to drink free radicals, the only monoatomic form that exists. Iodine free radicals are not transported freely in our bodies because they are too reactive. Elemental iodine preparations, including iodine dissolved in glycerol, may be helpful products for external antiseptic use rather than a supplement.

Another form of iodine supplement includes a mixture of algae and thyroid extract in glycerin, water and ethanol. This is likely not harmful because it contains T3 and T4 only in very small amounts, and the recommended serving size is also small. Other complex formulae that contain elemental iodine are a useful antiseptic, but not a good supplement. Iodine trichloride should be avoided as a supplement because it is too toxic.(19)

Summary

The established RDA allowance for iodine (150 mcg/day) is inadequate for many individuals. In order to maintain optimum health, adults need 2-5 mg of iodide daily. Actually, this is in line with the upper safe limit of dietary intake of iodine established by FAO (30 mcg/kg/day). In case of a dysfunctional thyroid or other illnesses, such as fibrocystic breast disease or cancer, 15-50 mg daily may be needed. Ask your doctor about the alternatives to hormone therapy or taking iodine-containing organic drugs, because inexpensive orthoiodosupplementation would usually not be his/her first choice.

The best and safest form of iodine supplementation for a healthy adult is iodide. Iodides are naturally produced in larger quantities by various seaweeds.

Please consult your doctor about iodine supplementation, as in your particular case it may be contraindicated.

References:

1. Abraham GE. The History of Iodine in Medicine Part III: Thyroid Fixation and Medical Iodophobia. http://optimox.com/pics/Iodine/IOD-16/PUB_16.htm

2. Dommisse J. MD Best Kept Secret (2009) http://www.westonaprice.org/modern-diseases/best-kept-secret/#sthash.vdrKPaJw.dpuf

3. http://theiodineproject.webs.com/addadhdautism.htm

4. Hamza RT1, Hewedi DH, Sallam MT. (2013) Iodine deficiency in Egyptian autistic children and their mothers: relation to disease severity. Arch Med Res. 44(7):555-61. http://www.ncbi.nlm.nih.gov/pubmed/24120386

5. http://www.fao.org/docrep/004/y2809e/y2809e0i.htm

6. Abraham GE. The Concept of Orthoiodosupplementation and Its Clinical Implications. https://www.optimox.com/pics/Iodine/IOD-06/IOD_06.htm

7. http://www.webmd.com/women/hashimotos-thyroiditis-symptoms-causes-treatments#1

8. Abraham GE. The History of Iodine in Medicine Part I: From Discovery to Essentiality. http://optimox.com/pics/Iodine/IOD-14/PUB_14.htm

9. Abraham GE. The historical background of the Iodine Project. http://www.optimox.com/pics/Iodine/IOD-08/IOD_08.htm

10. Abraham GE. The History of Iodine in Medicine Part II: The Search for and the Discovery of Thyroid Hormones. http://optimox.com/pics/Iodine/IOD-15/PUB_15.htm

11. Kelly FC. “Iodine in medicine and pharmacy since its discovery , 1811-1961.” Proc R Soc Med, 1961; 54:831-836. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1869599/

12. Abraham GE. “The safe and effective implementation of orthoiodosupplementation in medical practice.” The Original Internist, 2004; 11(1):17-36. http://www.hakalalabs.com/Research/Abraham_OI_Mar04.pdf

13. Fallon Morell S. The Great Iodine Debate (2009) The WestonA. Price Foundation, http://www.westonaprice.org/modern-diseases/the-great-iodine-debate/

14. Abraham GE. The Wolff-Chaikoff Effect: Crying Wolf? https://www.optimox.com/pics/Iodine/IOD-04/IOD_04.html

15. Brownstein D. The Cancer-Iodine Connection, (2015) http://www.newsmax.com/Health/Dr-Brownstein/iodine-cancer-cell-death-fish-oil/2015/06/10/id/649877/

16. 6-Iodolactone, key mediator of antitumoral properties of iodine, M. Nava-Villalba, C. Aceves, (2014) Prostaglandins & Other Lipid Mediators 112, 27-33. https://www.researchgate.net/publication/263856609_6-Iodolactone_key_mediator_of_antitumoral_properties_of_iodine

17. Bacteriological Analytical Manual, R40 Lugol’s Iodine Solution (2001), http://www.fda.gov/Food/FoodScienceResearch/LaboratoryMethods/ucm062245.htm

18. Review of Atomidine, International Wellness Directory, http://www.mnwelldir.org/docs/reviews/atomidine.htm

19. Material safety data sheet, http://www.mnwelldir.org/docs/history/Iodine_Trichloride.pdf

20. Abraham GE. The historical background of the Iodine Project http://www.optimox.com/pics/Iodine/IOD-08/IOD_08.htm

21. Abraham GE and Brownstein D. A Rebuttal of Dr. Gaby’s Editorial on Iodine. (2005) Townsend Letter, The Examiner of Alternative Medicine, http://www.townsendletter.com/Oct2005/gabyrebuttal1005.htm

22. Christianson A. http://www.integrativehealthcare.com/why-i-discourage-high-dose-iodine/

23. Dach J. http://jeffreydachmd.com/iodine_is_safe

24. Gaby A. http://www.townsendletter.com/AugSept2005/gabyiodine0805.htm

Nutritional Medicine is Orthomolecular Medicine

Orthomolecular medicine uses safe, effective nutritional therapy to fight illness. For more information: http://www.orthomolecular.org

Access the original OMNS article, “The Need for Iodine Supplementation”: http://www.orthomolecular.org/resources/omns/v13n14.shtml

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2

ALKALINIZE RAPIDLY USING pH ADJUST

Fred Liers PhD alkalinize rapidly using pH AdjustYou’ve heard it before. Eat more fruits and vegetables to be alkaline. Consume more alkaline-forming foods. Eat fewer acid-forming foods to avoid acidosis. Balance your pH levels.

Maybe you’ve even studied lists or charts of acid- and alkaline-forming foods to encourage dietary choices for creating proper acid-alkaline balance.

It’s no secret that acid-alkaline balance is important for health. In fact, it is well established that pH levels in the range of 7.35–7.45 provide many benefits. The facts are the facts, and the science is sound.

ph value foods acid alkaline ph adjust

Consuming more alkaline-forming fruits and vegetables can help maintain proper pH in the body.

Yet, if creating alkalinity were that simple, then why are most individual’s pH levels acidic instead of alkaline? What can be done to remedy the endemic (and epidemic!) levels of acidosis we see today?

Consuming potassium-rich fruits and vegetables remains the most important means for maintaining alkaline conditions in the body. However, taking pH Adjust powder supplement is an effective adjunct not only for helping balance pH levels, but rapidly producing an alkaline state conducive to optimal health.

pH BALANCE BASICS

A pH of 7 is considered neutral. A slightly alkaline pH level – like 7.4 – is best for health, of course.

Known benefits of ideal pH levels (slightly alkaline) include:

• Optimal function of enzymes
• Proper mineral retention, including electrolyte reserves
• Better tissue oxygenation
• Beneficial effects on microbiome

Dietary intake of alkaline-forming foods is the most obvious way of supporting proper pH. Consuming a diet rich in alkaline forming foods, such as fruits and vegetables (particularly leafy green vegetables) and vegetable juices are proven means for successfully balancing the effects of acid-forming foods like meats, and most grains and starches (simple carbohydrates).

Vegetables and fruits contain potassium. Evidence shows that potassium is critical for producing alkaline conditions in the body.

Known factors producing overly acidic conditions in the body include consuming meats, sugar, processed foods, and simple carbohydrates like wheat, corn, rice, and most pastas and breads.

pH BALANCE ESSENTIAL FOR HEALTH

Despite the certain knowledge that consuming vegetables, vegetable juices, and certain fruits helps balance pH, most people’s pH levels are overly acidic. I personally know many people, often vegetarians, whose pH levels are perfectly within the range suggested for optimal health.

Yet, I also see that most people do not consume sufficient alkaline-forming foods (specifically vegetables and vegetable juices), and therefore I am not surprised that the pH levels of most people are overly acidic.

What people in the thick of life may not realize is the degree to which acidosis—chronic or otherwise—is taking a toll of their health. And how maintaining alkalinity can improve health, longevity and quality of life. Or how easy it can be to create and sustain alkaline conditions using diet and dietary supplements.

MODERN TIMES: CHRONIC ACIDOSIS FOR MOST

Government statistics show that individuals by far do not consume recommended amounts of fruits and vegetables. It makes me wonder what foods the average individual or family consumes daily. Fast foods, fried foods, GMO foods, sugar-laden foods, and processed foods, as well as artificial additives, pesticides and agricultural chemicals are not conducive to alkaline conditions.

Neither are high-nitrogen foods, like red meats and most high-protein animal foods, especially when over-consumed—and not balanced by potassium-rich plant foods.

It seems the diet and lifestyle of most people are such that they are overly acidic. This may be considered a symptom of “modern” life. Yet, while the acid-alkaline balance of ancient diets—and even the diets of Westerners into the 20th century may have been fundamentally better (i.e., more alkaline-forming), the principles of pH balance remain the same. The pH levels of individuals subsisting on grains in any historical period would be relatively acidic.

Beyond low potassium intake from vegetables and fruits, other factors associated with over acidity include alcohol and most pharmaceuticals, antibiotics, artificial sweeteners, preservatives and artificial colorings, low nutrient intake, chemical exposure, pollution, lack of exercise, shallow breathing, and chronic stress.

Given the prevalence of these factors, is it any wonder that maintaining alkaline conditions in the body has become difficult for the average person?

Some effects of acidosis:

• Fatigue
• Being “out of breath” easily and asthmatic symptoms
• Muscle cramping or pain—even with little exertion
• Feeling like can’t get sufficient air (low tissue oxygenation)
• Skin problems
• Allergies
• Headaches
• Weight gain

Importantly, studies indicate that long-term acidosis is linked to certain health conditions, including arthritis, diabetes, fibromyalgia, heart disease, osteoporosis, stroke, and other adverse conditions.

HOW TO BE ALKALINE: DIET AND pH ADJUST

The answer for maintaining alkalinity is to consume plenty of potassium-rich fruits and vegetables. Most people know that it is important to eat 4–6 servings of vegetables daily. Yet, how many actually do? And why is that?

Not unlike taking daily multivitamins and sufficient quantities of basic dietary supplements, maintaining proper pH levels is easier said than done for most people. It just is.

For example, what if you normally consume sufficient amounts of fruits and vegetables, but you are traveling? Or find yourself on a given day not maintaining sufficient intake to maintain optimal pH balance? Or inadvertently become exposed to “factors” that create acidosis?

If you regularly consume sufficient levels of vegetables, vegetable juices, and certain fruits, you will most likely be slightly alkaline most of the time. If you do not, then you will either need to increase your intake of these potassium-rich foods, or try something else, or both.

How do I know this? Because despite my rather large intake of vegetables, vegetable juices, and fruits, I discovered that I am myself not always sufficiently alkaline. When I recently used litmus paper to test my pH levels, I found to my surprise that I am not *always* as alkaline as I should be.

Fortunately, my father Hank Liers, who is our company’s formulator and founder, had something brewing in his mind the last few years.

Just as I was deeply wondering how to squeeze more vegetable juices into my busy schedule…he develops a formula that forever changes my perspective on acid-alkaline balance, not to mention keeping me alkaline — like all the time.

It is amazing and it is “something else.” He calls it pH Adjust. And that is what it does—adjust your pH—and fast!

pH Adjust

pH ADJUST can safely and effective alkalinize the body.

WHAT TO EXPECT: pH ADJUST BENEFITS

After taking a single dose of pH Adjust, my pH “litmus” paper turned from light-ish green to deep purple.

After taking a dose every day for 10 days, my litmus test paper is dark blue to purple nearly all the time.

In addition, my father, Dr. Hank, has noticed that by taking a single large dose (a rounded teaspoon) every morning upon arising and measuring his urinary pH levels shortly before taking the dose, his morning pH levels are consistently in the 6.8 to 8.0 range. Before initiating this practice his morning urinary pH range was 6.2 to 6.6. Using this same protocol, my mother has experienced the same pattern of morning urinary pH values.

Of course, urinary (and salivary) pH measurements over the day will show significant variations depending upon your dietary habits. However, it was noticed that the trend was to have the pH increase over time as the protocol was rigorously followed.

What changed? Well, our pH levels have changed—toward alkalinity—for one thing. For another thing, I notice I have greater stamina, breathe easier, and just “feel” better.

Another unexpected benefit: my teeth feel stronger. Go figure! I thought about it and I see that my body must be retaining minerals better.

When the body is acidic, minerals are required to “buffer” the acidity. The body will even pull minerals from bones or teeth to buffer acidity because it tries to balance acidity any way it can.

Does this mean you can stop eating vegetables—and just take pH Adjust? Absolutely “no” because your diet remains the single most important factor in keeping your body slightly alkaline. If anything, your intake of potassium-rich fruits and vegetables (like kale and other leafy greens) should increase or at least be maintained, if it is already sufficiently abundant in these foods.

The arrival of pH Adjust just means there is a highly effective tool (supplement) to help maintain proper acid-alkaline balance beyond your diet alone. It means that whenever your pH levels dip into an acidic zone, you can rapidly and effectively return yourself to an alkaline state independently of your immediate dietary circumstances. From this perspective, pH Adjust is like an insurance policy: a useful means to attain alkalinity if and when diet alone is not enough. That’s why pH Adjust is a dietary “supplement.”

I cannot guarantee you will get the exact results I obtained. Your results will depend on your diet, level of acidity, and exposure to other factors known to determine pH levels. Nevertheless, the science behind the development of pH Adjust is based on the fact that certain key forms of minerals like potassium and sodium bicarbonate and magnesium carbonate create alkaline conditions in the body.

TELL ME MORE ABOUT pH ADJUST

pH Adjust is a fluffy, mild-tasting power formula you add to water, juice, or other liquid drinks in small amounts (about 1/4 teaspoon) that rapidly “adjusts” your pH levels toward alkaline.

pH Adjust contains potassium bicarbonate, magnesium carbonate, potassium glycinate, and sodium bicarbonate. A one gram serving (about a rounded ¼ tsp) contains about 300 mg of bicarbonate, 260 mg of carbonate, 142 mg of potassium, 105 mg of magnesium, 48 mg of sodium, and 100 mg of glycine.

Potassium, sodium, and magnesium are key minerals involved in many important functions in the body. When combined in bicarbonates (potassium & sodium), carbonates (magnesium), and glycinate (potassium) they help to adjust and balance pH levels essential to optimal body function.

You can read more in depth about pH Adjust on our product page.

pH ADJUST VERSUS SODIUM BICARBONATE (BAKING SODA)

For years, health professionals have advocated the use of baking soda (sodium bicarbonate) for its alkalinizing effects and the benefits associated with balanced pH levels.

Baking soda is cheap and effective, but consuming it has drawbacks. Its key flaw is sodium. Sodium bicarbonate provides relatively too much sodium (salt), and as such, its consumption must be monitored so as to avoid elevated sodium levels. Too high sodium levels create known risks for high blood pressure (hypertension) and cardiovascular health.

pH Adjust is formulated to avoid high sodium levels. One key to the formula is its 3:1 ratio of potassium to sodium. These are balanced amounts, as well as levels the body itself favors in terms of absorption and retention. Moreover, these levels maintain a balance known to be heart-healthy and that keep the formula low in sodium, when used as directed.

Most individuals already consume sufficient (or more than sufficient) sodium, and therefore require other minerals to balance that intake. pH Adjust not only contains low levels of sodium, but also provides minerals (potassium, magnesium) needed to balance sodium levels in the body.

ph Adjust

A refreshing glass of water with pH Adjust. Can alkalinizing get any simpler?

TASTE

Taste is another advantage of pH Adjust. Baking soda literally tastes “salty” because it is full of sodium. For a long while, I used baking soda to balance my pH levels toward greater alkalinity.

I stopped taking baking soda not only because my dietary intake of alkaline-forming foods is usually sufficient (relative to the average person), but also because I no longer could stomach the salty taste. I continue to “slug” down baking soda every now and then, but I have to suppress my overriding desire to spit it out—it’s simply too salty!

Imagine me now: happily drinking my pH Adjust in water every morning (and sometimes afternoon) which tastes good! I cannot actually say it tastes like a dessert because it is more like neutral to slightly sweet in taste (partly due to its glycine content). It goes down smoothly with no detectable “salty” taste.

EVERYTHING TO LOVE IN AN ALKALINIZING FORMULA

I would say pH Adjust has everything I would ask for in an alkalinizing, pH balancing formula. It alkalinizes me–FAST! It provides critical minerals required for health in balanced amounts, including potassium and magnesium in easily assimilated forms. It is low in sodium. It tastes good. What more can you ask for?

pH Adjust probably is the most sophisticated alkalinizing formula available. Certainly it is better than calcium- and chemical-laden antacids, which I would never take anyway. pH Adjust’s elegant design makes baking soda seem plain and salty by comparison not to mention highly imbalanced in terms of its mineral content.

TRY pH ADJUST AND MEASURE YOUR pH

No one can really know the effects of such an excellent pH balancing formula as pH Adjust without accurately measuring their pH levels. That is the reason HPDI offers Hydrion litmus paper, which is simply a litmus paper for measuring pH.

Whether you use Hydrion brand papers won’t make a difference. Any good-quality litmus paper should work just fine. Use a small, one- or two-inch strip of pH paper to quickly dip into a saliva or urine sample (i.e., to test salivary or urinary pH). Hint: urinary pH tends to be more accurate because saliva tends to be affected by foods. Test salivary pH well away from meals.

hydrion litmus paper ph Adjust

Order a container or two of pH Adjust, which we’ve purposefully kept low cost so both health professionals and individuals can make it a regular part of their pH balancing regimes. At $19.95 for retail customers (and less for HPDI resellers/wholesale customers), you will see that there is significant value for the price of pH Adjust.

As for serving size, one container provides 250 one-gram servings (about a rounded 1/4 teaspoon). Even if you were to take larger amounts (like I do), say up to one teaspoon daily, there would be nearly 63 servings per container. That’s enough for two full months of servings assuming daily usage.

NOTHING TO LOSE, JUST pH BALANCE TO GAIN

For every person I know whose pH levels lean toward acidic end of the spectrum, there is a container of pH Adjust waiting to be opened. Seriously though, if you’re not getting quite enough potassium-rich vegetables in your diet (or think you are but actually are not), then please consider pH Adjust your supplemental “friend-in-need.”

And if you (or your clients) suffer from long-term, chronic acidosis due to a potential variety of causes, then you have much more to gain. Stop the spiral of acidity from keeping you from attaining much better balanced pH levels—and thereby improved health—by trying our simple blend of minerals in bicarbonate, carbonate, and glycinate forms, called pH Adjust.

Then measure your pH using litmus paper—and see the difference for yourself. Litmus paper doesn’t lie, and it gives you a reliable indicator of the progress you’re making and your current pH status in real time.

After using pH Adjust and measuring your results with litmus paper, then decide for yourself. Is pH Adjust worth its name? Does it effectively help you balance your pH? We think your answer will be “yes.” We believe you will love pH Adjust as much as we love it.

Be alkaline!!

RESOURCES

pH ADJUST

PH ADJUST ALKALINIZING FORMULA – NEW PRODUCT! (Blog)

List of acid-forming and alkaline forming foods

Hydrion Litmus Paper

hydrion ph paper litmus ph adjust

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pH ADJUST ALKALINIZING FORMULA – NEW PRODUCT!

Dr. Hank Liers PhD pH Adjust alkalinizing mineral formulaFred Liers PhD pH Adjust alkalinizing mineral formulaToday HPDI launches a new product: pH Adjust. The new formula was created by Dr. Hank Liers, PhD. As its name implies, its primary application is to help balance pH levels in the body. That is, to support the creation of alkaline conditions — or alkalinization.

Because pH Adjust alkalinizes the body, it thereby may effectively counteract overly acidic conditions (acidosis), including acidic conditions in the digestive tract, blood, kidneys, and other organ systems.

 

pH Adjust

Our newest product pH ADJUST

Given the fact that acidosis—including chronic, low-grade acidosis—is common among individuals living in industrialized nations consuming high-levels of processed foods and other acid-forming foods, pH Adjust represents a simple, yet powerful means for achieving a healthy acid-base balance in the body.

HPDI specializes in the formulation of nutritional supplements, including vitamin formulas such as multivitamins and other foundational supplements, advanced antioxidant formulas, high-RNA superfoods, and various mineral products, including magnesium. pH Adjust may be considered a mineral product. Yet, it is different than any other HPDI formula.

That is, pH Adjust is not primarily formulated to provide nutrients to meet nutritional needs. Rather, the formula supports optimal health by facilitating improved acid-alkaline balance in the body. It may be used to effectively neutralize acidic conditions, and help counteract the tendency toward acidosis that persists among many individuals.

THE IMPORTANCE OF pH BALANCE

Health experts know that pH balance is extremely important, and that acidosis in the body contributes to various states of less than optimal health. It is known that acidic conditions can lead to adverse effects in many bodily systems, including the circulatory system, immune system, skeletal system, excretory system, muscular system, and reproductive system.

Chemically, pH stands for hydrogen ion concentration. The pH scale runs from 7 to 14, and pH 7 is considered neutral. A pH value of less than 7 is considered acidic whereas a pH value of greater than 7 is considered basic or alkaline. In the body, the ideal pH is somewhat alkaline: 7.30 to 7.5.

For therapeutic purposes, individuals can for short periods of time (from a few days to a couple weeks) raise their pH levels to 8.0. That is, short-term increases in pH (to 8.0) can be useful for rapidly changing conditions in the body from acidic to basic (alkaline).

DIET AND pH (ACID-BASE) BALANCE

Herman Aihara (author of Acid & Alkaline) and others have contributed to our understanding of acid and alkaline states in the body, and the roles played by foods in creating either conditions of acidity or alkalinity. In general, protein foods are “acid-forming” foods whereas most vegetables are “alkaline-forming” foods. A table of acid and alkaline forming foods are on our website at Effect of Food on Body Chemistry.

Thus, proteins (containing more nitrogen) tend to form acids in the body whether or not they themselves are acid, and vegetables (containing more potassium) tend for form bases in the body whether or not they themselves are basic. This fact supports the importance of vegetables in the diet not only for nutrients, but also as a means for ensuring acid-base balance.

An excellent food that provides a high potassium content is Dr. Hank’s Vegetable Soup. This soup tastes great and can help to keep a healthy acid-base balance in the body.

An excellent article published in the American Journal of Clinical Nutrition in 1998 looked at the key factors that determine acid-base balance in the body. Their conclusion was: “In summary, the results of this study indicate that in normal humans eating ordinary whole-food diets, the major determinants of differences in NEAP rate (net endogenous acid production) among subjects are differences in the protein and potassium content of the diet and that the absolute rate of net endogenous acid production for a given diet can be predicted simply from knowledge of the diet’s protein and potassium content.”

Potassium-containing foods provide the body with potassium that it can use to create alkaline conditions. Sodium can also support alkaline conditions in the body. In fact, potassium and sodium work together in the sodium-potassium pump that pumps sodium ions out of cells and potassium ions into cells using ATP, and that performs many essential functions, including nutrient transport, cell-volume regulation, and nerve conduction.

Danish chemist Jens Christian Skou shared the 1997 Nobel Prize in Chemistry for having discovered this pump, i.e., the ion-transporting enzyme, Na+K+ -ATPase in 1957 while at the University of Aarhus in Denmark.

It is notable that most individuals in Western societies obtain more than sufficient sodium and often less than sufficient potassium. Excessive sodium intake is associated with adverse effects on cardiovascular health.

In an interview with Dr. Richard Passwater in 2001, Dr. Richard Moore said: “When I looked at all the published data for both potassium and sodium in the diet—or in the urine which reflects the diet-and then looked at the incidence of hypertension, I could see that, as the K Factor (ratio of potassium to sodium in the diet) got above one or two, there was significantly less hypertension (high blood pressure). Actually a diet with a K Factor of three or above is not bad, but, for practical purposes, I think a K Factor above four is a better goal. Of course, even higher than that would be better in terms of general health. I say this based upon the fact that our ancestors had a K Factor of about 16 to 1 and we evolved having a K Factor something like that.”

Based upon this information, we have chosen a 3:1 ratio of potassium to sodium in the pH Adjust formula so that it consistent with a heart-healthy diet.

MEASURING pH LEVELS

The best way to measure pH levels is to use litmus paper. HPDI offers litmus paper in rolls (Hydrion brand) for this purpose providing about 100 tests per roll. You can test salivary or urinary pH. In order to test salivary pH, simply use a small strip of pH paper to dip into a small amount of saliva. Advantages of pH paper include rapid results, ease of use, and cost effectiveness.

litmus paper pH Adjust alkalinizing formula alkaline

Using pH paper is a fast, easy means to measure pH accurately

The color of the litmus paper indicates the pH level in saliva. Most litmus paper comes with an indicator chart showing colors corresponding to various pH levels. Alkaline states will generally produce a dark green, blue or purple color (most basic). Acidic states will range from yellow (most acidic) to light green.

Salivary pH and urinary pH are significantly affected by recent food consumption and other factors, so it it best to test pH hours after meals. We prefer to measure urinary pH since results are more consistent. Measuring urinary pH is a simple as placing a few drops of urine on the paper or dipping the paper into a sample cup.

It is best to measure your pH in the morning before consuming foods or drinks. Salivary and urinary pH are affected by recent food consumption, so re-test several hours after eating, and additionally throughout the day.

A consistent pH measurement of less than 7.0 indicates that you are too acidic (values less than 6.2 show extreme acidity). This indicates that you should consume more alkaline forming foods and/or take pH Adjust. A single dose of pH Adjust can change conditions in the body from acidic to alkaline within a few hours.

MINERALS: POTASSIUM, MAGNESIUM, AND SODIUM

As we mentioned, pH Adjust is not primarily formulated to provide minerals or other essential nutrients. HPDI has other products (like multivitamins and single-nutrient formulas) for that purpose.

However, pH Adjust is a mineral providing formula. That is, it provides potassium (in the forms of bicarbonate and glycinate), magnesium (in the form of carbonate), and sodium (in the form of bicarbonate).

And while the levels of potassium (141.6 mg or 4% daily value) and sodium (47.8 mg or 2% daily value) per dose of pH Adjust are relatively small, the level of magnesium is significant (105 mg or 26.3% daily value).

Moreover, the levels of these minerals in pH Adjust are balanced, so that sufficient potassium is obtained relative to sodium, and that sodium remains low in the formula (for reasons previously considered).

Note that the amounts of minerals listed (above) are obtained per dose, so additional doses will correspondingly increase the amounts of minerals. However, multiple doses should not significantly increase sodium levels. For example, more sodium may be obtained from a single salty snack than one or two doses of pH Adjust.

pH Adjust alkalinizing formula supplement facts alkaline

Supplements Facts table from pH Adjust product label.

DOSE INFORMATION

One dose is 1/4 teaspoon. For extremely acidic conditions, you can take 4–10 doses per day, depending on the level of acidity and using pH paper as a guide to ensure that pH levels remain balanced. That is, the goal is to balance pH and to not become too alkaline (a condition of alkalosis may occur above pH 8.2).

INFORMATION FROM THE PRODUCT PAGE (INTEGRATEDHEALTH.COM)

pH ADJUST may be used to increase salivary and urinary pH; counteract overly acidic conditions in the digestive tract, blood, and kidneys; and to supplement the body with the minerals potassium, magnesium, and sodium.  The product contains (in powder form) potassium bicarbonate, magnesium carbonate, potassium glycinate, and sodium bicarbonate. Each serving (about ¼ tsp) contains about 300 mg of bicarbonate, 260 mg of carbonate, 142 mg of potassium, 105 mg of magnesium, 48 mg of sodium, and 100 mg of glycine.

NUTRITIONAL CONSIDERATIONS AND APPLICATIONS

The minerals potassium, sodium, and magnesium are key substances that are involved in many important functions in the body. When combined in bicarbonates (potassium & sodium), carbonates (magnesium), and glycinate (potassium) these chemicals can help to adjust and balance pH that are crucial to body function.

The processed food diets with a high protein content consumed by many people in the US and elsewhere produce conditions in the body of acidity. This in turn leads to decreased oxygenation of our cells and a greater use of anaerobic processes in metabolism. This, in turn, leads in inadequate ATP (energy) production and the presence of unwelcome anaerobic cells and organisms.

BICARBONATE

Bicarbonate is a major element in our body. Secreted by the stomach, it is necessary for digestion. When ingested, for example, with mineral water, it helps buffer lactic acid generated during exercise and additionally reduces the acidity of dietary components. Additionally, it has a prevention effect on dental cavities. Each ¼ tsp of pH ADJUST contains about 300 mg of bicarbonate.

Bicarbonate is present in all body fluids and organs and plays a major role in the acid-base balances in the human body. The first organ where food, beverages and water stay in our body is the stomach. The mucus membrane of the human stomach has 30 million glands which produce gastric juice containing not only acids, but also bicarbonate.

The flow of bicarbonate in the stomach amounts from 24.4 mg/hr for a basal output to 73.2 mg/hr for a maximal output. Thus at least 500 mg of bicarbonate is secreted daily in our stomach. This rate of gastric bicarbonate secretion is 2-10% of the maximum rate of acid secretion. In the stomach, bicarbonate participates in a mucus-bicarbonate barrier regarded as the first line of the protective and repair mechanisms. On neutralization by acid, carbon dioxide is produced from bicarbonate.

Effects of ingested bicarbonate: For digestion, bicarbonate is naturally produced by the gastric membrane in the stomach. This production will be low in alkaline conditions and will rise in response to acidity. In healthy individuals this adaptive mechanism will control the pH perfectly. To modify this pH with exogenous doses of bicarbonate, some clinical experiments have been conducted with sodium bicarbonate loads as high as 6 g. Only a transient effect on pH has been obtained. It is quite possible that bicarbonate in water may play a buffering role in the case of people sensitive to gastric acidity. Thus bicarbonate may be helpful for digestion.

The most important effect of bicarbonate ingestion is the change in acid-base balance as well as blood pH and bicarbonate concentration in biological fluids. It has been studied particularly in physically active people. Among the types of acid produced, lactic acid generated during exercise is buffered by bicarbonate. In a study on sports, a dose of 0.3 g per kg of body weight of sodium bicarbonate was given (15.25 g bicarbonate for a man of 70 kg) to subjects before performing 30 minutes cycling. While blood pH was increased and then maintained constant with this bicarbonate load due to the changes in blood bicarbonate concentrations, increased acidity and decreased bicarbonate blood concentration were observed in controlled subjects.

Prevention of renal stones: Bicarbonate also reduces the acidity of dietary components such as proteins. As an example, adding sodium or potassium bicarbonate to subjects on a high protein diet known to acidify urine and leading to hypercalciuria (high level of calcium in urine) has been shown to greatly reduce calcium urinary excretion. The effect has been observed with 5.5 g of bicarbonate supplement received daily for two weeks. A recent study highlights that a bicarbonate-rich mineral water could be useful in the prevention of the recurrence of calcium oxalate and uric acid renal stones.

Controls water absorption: many oral hydration solutions contain bicarbonate showing the usefulness of bicarbonate to control water absorption in patients at risk of dehydration.

Maintains blood pressure: Sodium intake is restricted in patients with hypertension, but it is demonstrated that the accompanying anion, such as bicarbonate, plays an important role. It is now well established that sodium bicarbonate does not raise blood pressure to the same extent as do the corresponding amounts of sodium chloride.

Decreases dental plaque: Bicarbonate has been shown to decrease dental plaque acidity induced by sucrose and its buffering capacity is important to prevent dental cavities. Other studies have shown that bicarbonate inhibits plaque formation on teeth and, in addition, increases calcium uptake by dental enamel.

CARBONATE

pH ADJUST contains about 260 mg of carbonate (and 105 mg of Mg) in the form of magnesium carbonate. Magnesium carbonate is used as an antacid that gets converted to Magnesium Chloride (MgCl) and CO2 by stomach acid. MgCl is a well absorbed form of magnesium.

MINERALS

The functions of the key minerals in pH ADJUST are described below. Each serving (about ¼ tsp) of pH ADJUST contains 142 mg of potassium, 105 mg of magnesium, and 48 mg of sodium.

POTASSIUM BENEFITS

Potassium levels influence multiple physiological processes, including:

  • Resting cellular-membrane potential and the propagation of action potentials in neuronal, muscular, and cardiac tissue. Due to the electrostatic and chemical properties, K+ions are larger than Na+ions, and ion channels and pumps in cell membranes can differentiate between the two ions, actively pumping or passively passing one of the two ions while blocking the other.
  • Supports hormone secretion and action
  • Improves vascular tone
  • Regulates systemic blood pressure
  • Increases gastrointestinal motility
  • Required for acid–base homeostasis
  • Supports glucose and insulin metabolism
  • Plays role in mineralocorticoid action
  • Supports renal concentrating ability
  • Regulates fluid and electrolyte balance

MAGNESIUM BENEFITS

Magnesium levels influence many physiological processes and functions. These include:

  • Increases energy by greater production of ATP (adenosine triphosphate) in cells
  • Supports production and function of over 300 enzyme systems in the body
  • Relaxes muscles / reduces muscle tension
  • Boosts vitality, endurance, and strength
  • Improves cardiovascular / heart health (relaxes cardiac muscle)
  • Relieves pain, including chronic pain
  • Ideal for arthritis / fibromyalgia / joint pain
  • Improves health of skin and mucous membranes
  • Eases headaches and migraine headaches
  • In sports medicine — replenishes Mg levels for energy (combats fatigue, and
    soothes pain and sore muscles)
  • Improves mood and reduces stress
  • Increases memory and cognitive functions
  • Boosts immune system
  • Improves assimilation of calcium / builds stronger bones
  • Balances calcium and magnesium levels in cells
  • Proven antimicrobial and antiseptic
  • Raises DHEA (dehydroepiandrosterone) levels naturally
  • Eases menopause and premenstrual syndrome (pms)
  • Supports healthy libido (and endocrine system)
  • Anti-aging, rejuvenating, revitalizing
  • Keeps cell membranes flexible
  • Controls cholesterol production in the body
  • Regulates blood sugar levels / needed for insulin production, transport, and
    function in cells
  • Supports antioxidant systems

SODIUM BENEFITS

Sodium levels influence many physiological processes and functions. These include:

  • Helps to regulate fluid levels in the human body.
  • Preventing sun stroke or heat exhaustion by replacing the loss of essential electrolytes.
  • Supports brain function – the brain is very sensitive to change in sodium levels of the body; deficiency of sodium often manifests as confusion and lethargy.
  • Along with properly hydrating the body, it is also important to supplement one’s body with mineral-rich juices (including potassium, magnesium and sodium) to prevent muscle cramps.
  • Is an important hydrating product that defends against the free radicals that accelerate the aging process.
  • Helps to eliminates excess carbon dioxide in the body.
  • Helps to facilitate the absorption of glucose by cells, resulting in the smooth transportation of nutrients in the body’s cell membranes.
  • Supports acid/base balance by altering the proportions of acid-base alkali phosphates in the body.
  • Regulates fluids by balancing the osmotic pressure in the human body
  • Shares an association with chlorides and bicarbonates in maintaining a sound balance between positively charged and negatively charged ions.

pH ADJUST PRODUCT DETAILS

COMPOSITION: One gram (about 1/4 tsp) of pH ADJUST provides the following percentages of the Daily Value

 Amount Per Serving % Daily Value
Potassium (from KHCO3 & glycinate)
Magnesium (from MgCO3)
Sodium (from NaHCO3)
141.7 mg
105.0 mg
47.8 mg
4%
26.3%
2%

Other ingredients:  None

INGREDIENTS: Potassium bicarbonate, magnesium carbonate, potassium glycinate, and sodium bicarbonate.

DIRECTIONS: As a dietary supplement, take ¼ tsp in 4–8 ounces of purified water preferably away from food, or as directed by a health care professional.

For extremely acidic conditions (pH consistently less than 6.2), try 4–10 doses per day, depending on acidity level. you may take multiple 1/4 tsp doses at once—we ourselves often take 1 tsp in a single dose. Use pH paper to ensure pH levels remain balanced, and do not become too alkaline (alkalosis may occur above pH 8.2).

DOES NOT CONTAIN: wheat, gluten, rye, barley, oats, corn, yeast, egg, dairy, soy, GMOs, sugar, wax, artificial preservatives, flavorings, or colorings.

SOURCES & RESOURCES

Acid & Alkaline by Herman Aihara

pH Adjust

Litmus Paper (Hydrion)

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FOUNDATIONAL SUPPLEMENTS REMAIN FUNDAMENTAL

Fred Liers PhD foundational supplements remain fundamentalI spoke with an old friend recently. I will call him Joe.

Joe has digestive tract issues, including extreme diverticulosis. While I have provided him with suggestions for improved nutrition and supplement use in recent years, he hasn’t followed any of my recommendations seriously.

Instead Joe opted for a more conventional route. Now his situation has worsened dramatically, and he says he’s ready to start a program of improved nutrition and supplements. That’s good, even though it would be easier had he started sooner. Like I said, Joe is a good friend. I wish him health and happiness.

My initial advice to Joe remains the same as it would be for everyone. He should start with a dietary changes and a solid program of foundational supplements like those in the HPDI Foundational Supplements Program. He can later add enhancements and condition-specific formulas addressing his unique needs.

WHY FOUNDATIONAL SUPPLEMENTS?

The HPDI Foundational Supplements program was developed by Hank Liers, PhD to provide optimal levels of basic nutrients important for good health. In our experience, the HPDI program works to support vibrant health. It also helps cover gaps left by poor diet, incomplete nutritional supplementation, and imbalances due to genetic factors. It helps to compensate for lower nutrients levels found in many modern foods both processed and/or produced by modern industrial agricultural methods (i.e., that deplete soils or block nutrient uptake).

Read more the HPDI Foundational Supplements Program.

6-types-supplements-foundation

HPDI’s foundational supplements program includes six categories of dietary supplements.

JOE’S DIET IS NOT SO GOOD

I don’t like to be overly prescriptive about food. But Joe is a “carb” lover and with a history of consuming processed, high-sugar foods, and junk foods. For example, processed breads, donuts, candy bars, and soda have been staples for years. It doesn’t help many of these foods either are GMO or high in glyphosate (the main ingredient in the herbicide RoundUp), which is known to produce adverse gastrointestinal (and other harmful) effects.

He has reduced his intake of high-carb, sugary foods in recent years. In fact, he has significantly cut back on simple sugars because he finds they drain his energy and don’t help his digestion.

I suggested he continue cutting back on simple carbs and sugars, and that he add more fresh vegetables and high-quality proteins to his diet. I recommend organically grown and non-GMO foods.

I can’t say what caused Joe’s diverticulosis. But I can say that changes in his diet are necessary to support optimal health, as well as healing of damage to his digestive tract.

It doesn’t help that Joe takes several drugs, including a long-term antibiotic for a stubborn urinary tract infection, and a laxative (containing polyethylene glycol) for his constipation and diverticulosis. These drugs may help in the short term, but they far from ideal for long-term use.

Joe himself isn’t pleased with his need for drugs. He intends ultimately to stop them when possible.

He has been having trouble sleeping in recent years. I suspect this may be related to his troubles with his intestinal tract, dysbiosis, and possibly issues with his microbiome.

SUPPLEMENTATION

Joe sent me his supplement schedule and results from a few health tests to review. He has “nutrition-oriented” doctors whose advice he follows quite rigorously.

I reviewed his supplement schedule and health test results. His results include some in-depth genetic tests, which provide insights into potential health concerns, and practical advice for nutritional supplementation.

IMBALANCES CALL FOR FOUNDATIONAL NUTRITION

I saw glaring gaps in Joe’s supplement schedule. There are major imbalances in his supplement program. For example, I see no multivitamins or vitamin C/antioxidant formula, which are basic to the HPDI foundational program.

Indeed, for all the good elements, his program unfortunately is hit-or-miss in terms of providing a complete spectrum of essential nutrients.

On the upside, he’s been taking a few specific-nutrient supplements daily:

5,000 mg of vitamin D (25-hydroxy).

3,000 mg of Omega-3 (EPA/DHA) and 1,000 mg of flax seed oil.

He gets some coenzyme B vitamins:

2,000 mcg of a methyl folate (MTHF)

1,000 mcg of B12 as methylcobalamin daily.

Taking these standalone coenzyme B vitamins is good because test results indicate he has the heterozygous genotype for the MTHFR C677T (C/T) and MTHFR A1298C (A/C). The presence of both polymorphisms can result in significantly reduced activity of MTHFR potentially leading to reduced production of the active form of folate (L-methylfolate).

As his test results stated: “Reduced levels of L-methylfolate lead to decreased production of neurotransmitters, reduced conversion of homocysteine to methionine, and reduced s-adenosylmethionie (SAMe) concentrations.”

GAPS: HIT OR MISS ON FOUNDATIONALS

I asked about his multivitamin and vitamin C intake. He said he takes them despite the fact they are absent from his supplement schedule. I supposed they were absent from his schedule because his doctors want to make sure he gets his vitamin D, folate, methylcobalamin, and essential fats, but aren’t too concerned about whether or not he takes a complete multivitamin, vitamin C/antioxidant formula, or complete B-complex vitamins.

Joe told me he takes a multivitamin, B-complex, and vitamin C supplement. But didn’t take all of them daily.  All three products came from a “big-box” store known for low prices.

Joe therefore consumed a few specific, advanced, medical-quality formulas at the direction of his doctors. Yet, he purchased low-end multivitamin, vitamin C, and B-complex products that can or should be the foundation of his supplement program.

His multivitamin was a low-potency formula providing only 3–500% of the daily value for most nutrients with many at exactly 100%. Not only is this multivitamin low-potency, but its forms are conventional (no coenzyme vitamins or advanced forms). Moreover, it is full of unnecessary additives and fillers like polyethylene glycol, polyvinylpyrrolidone, and sodium benzoate.

His vitamin C was 500 mg. He didn’t take it every day and when he did, he took only one or two.

WHAT I DID FOR JOE

Joe and I talked about his situation. He agreed to receive a package of supplements. Actually, I attempted several years ago to help him get onto a foundational supplements program. He took some supplements and he definitely noticed a difference in how he felt. Yet, he wasn’t ready to take a complete system of high-quality supplements. He finally agreed to try the program.

I sent him a package of HPDI supplements. It included two foundational supplements: Hank & Brian’s Mighty Multi-Vite! (multivitamin) and PRO-C (vitamin C/antioxidant formula). I did not include essential fats because he already takes them. I will send Rejuvenate! PLUS superfood and Intestinal Rejuvenation Formula in a separate shipment.

Joe now takes the Mighty Multi-Vite! and PRO-C, as well as Myo-Mag (magnesium) daily. He is already noticing he needs less of his laxative, and has scaled back his dosage. He can see the day is coming when he can wean himself entirely of it. He has updated his supplement schedule to include all of his supplements, so he can better track his supplement intake and ensure consistency.

I also sent him a Warrior Sleep for his sleeping troubles, and a bottle of Restore, which may help his intestinal tract and problems related to it.

PRO-C foundational supplements vitamin c

PRO-C is one of HPDI’s premier vitamin C / antioxidant formulas.

In forthcoming blog posts I plan to document the status of Joe’s health, including his energy levels and subjective feelings about his health. We will see how foundational supplements help him.

Not everyone is as fortunate as as Joe to have a friend who will send supplements and more importantly, talk to him in depth about nutrition and the need for foundational supplements.

WHAT JOE CAN DO FOR HIMSELF

It is my hope that Joe will follow the foundational supplements program, regain some health, and continue to improve by remaining on the program with HPDI supplements. He can take on his foundational supplements program as a mission for his own long-term health.

I also hope Joe’s experience with HPDI supplements will be an example to others who may be in similar situations. This includes individuals who don’t know where to begin, and those who take a variety of supplements yet aren’t receiving a full complement of essential nutrients.

Others who may be in similar situations to Joe’s include those who take supplements as directed by their doctor, but whose supplement schedule is “hit-or-miss,” which I suspect is a lot of people. Or those taking low-potency multivitamins or B-complex vitamins or just 500 mg of vitamin C daily. Also those taking basic supplements sporadically or whenever they “feel like it.”

Joe is far from being alone in having significant gaps in his foundation of essential nutrients that support good health. His doctors missed those gaps despite their best intentions to provide him with advanced nutrients based on genetic testing to assess potential deficiencies. “Losing sight of the forest for the trees” can happen to the best of us. In fact, the average person’s nutrient profile is not unlike Joe’s in many respects. And like Joe’s situation, foundational supplements can help close the gaps.

FOUNDATIONAL SUPPLEMENTS CAN LEAD TO BETTER HEALTH

There are many reasons I feel confident that HPDI foundational supplements will continue helping Joe. Not only am I not surprised he is noticing results, but also I’ve seen health improve in many (perhaps hundreds of) individuals when they begin a complete foundational supplements program, and then especially when they maintain it.

Good results are not surprising when the levels of nutrients increase from just 100% of the daily value for most nutrients to much higher levels.

Results improve over time when the body continues receiving high levels of essential nutrients.

Dietary supplements are generally non-toxic so there is little risk of problems when the body receives more than adequate nutrients to meet its needs.

And why take just the minimum? Minimum amounts of nutrients tend to perpetuate deficiencies when you consider factors like poor diet, increased oxidative stress, toxic exposures (leading to greater nutrient needs to support detoxification), and genetic factors (e.g., enzyme deficiencies).

multivitamins HPDI foundational supplements

HPDI Multivitamins include Mighty Multi-Vite!, Multi Two (caps and tabs), Mini Multi, and Chewable Kids Mighty-Multi!

HPDI FOUNDATIONAL SUPPLEMENTS PROGRAM

The HPDI Foundational Supplements Program until recently consisted of four types of supplement:

• High-Potency Multivitamin

• Vitamin C / Antioxidant Formulas

• Essential Fatty Acids

• High-RNA Superfoods (providing dietary nucleic acids)

Just last month, HPDI revised the Foundational Supplements Program to include two additional types of supplements:

• Gut Health formulas (such as Restore)

• Hydrogen products (such as Megahydrate and Active H2)

For more information on the revised system, see Amending the HPDI Foundational Supplements Program (blog post) by Hank Liers, PhD.

All six of these types of formulas comprise the HPDI Foundational Supplements Program. It is our belief that these six types of formulas are foundational to health regardless of whether you use HPDI’s supplements or those of another company (as long as they are high-quality, high-potency, provide the proper forms, and do not contain unnecessary excipients or toxic ingredients).

The HPDI foundational supplement program is the result of many years of product formulation, evaluating scientific research, following the experience of end-users, feedback from doctors and other clients, and staying on the cutting-edge of nutritional science. HPDI is known for updating its formulas as new information becomes available regarding better forms of nutrients, or means form improving nutrient uptake or utilization.

HPDI FOUNDATIONAL SUPPLEMENTS

HPDI formulates four of the six types of formulas in the Foundational Supplements Program.

HPDI Multivitamins include: Hank & Brian’s Mighty Multi-Vite!, Multi Two (caps or tabs), Mini Multi (for the chemically sensitive), and the Kid’s Mighty Multi!

HPDI Vitamin C / Antioxidant formulas include: PRO-C, Ultimate Protector Nrf2 formula, Buffered C (tabs), and Buffered C (powder)

HPDI Essential Fatty Acids: Essential Fats Plus E

HPDI’s Rejuvenate! Superfoods include: Rejuvenate! Original (densely green), Rejuvenate! PLUS (lightly green), and Rejuvenate! Berries & Herbs (no greens). See the Rejuvenate! side-by-side comparison.

HPDI foundational supplements are formulated by Dr. Hank Liers, PhD. Hank is known for formulas that utilize only the highest-purity and highest-quality ingredients, and for his emphasis on natural forms (e.g., coenzyme forms) best recognized and utilized by the body.

FOUNDATIONAL SUPPLEMENTS ARE FUNDAMENTAL

Foundational supplements are the foundation for good health. That is why we call them foundational. This is also why we believe so strongly in providing a strong foundation of nutrients before recommending what we call enhancement formulas, specific-condition formulas, or other add-ons (such as a soil-based probiotic formula).

That is to say, a given individual will possibly have many requirements for nutrients specific to their needs. Such formulas may include magnesium, iodine, certain B vitamins like coenzyme folate (5-MTHF). An individual may also require formulas specific to certain issues, concerns, or organ systems, such as formulas targeting joint health, bone health, allergies, blood sugar, liver health, and others. In fact, HPDI formulates formulas specific to these needs.

Yet, before specific needs are addressed, or at least concurrently, HPDI believes that foundational nutrients must provide the base or foundation upon which all other nutrients, condition-specific formulas, or enhancement formulas rest.

One danger, as we saw with Joe’s supplement schedule before he started taking HPDI foundational supplements, was putting the cart before the horse. That is, finding a person in a situation where there are several or numerous advanced nutrients being taken. Yet, where the “base” is relatively weak due to low-potency supplements and/or lack of basic nutrients. In this type of situation, it is less likely that the addition of several advanced nutrients can make as much of a difference for health because key nutrients are missing.

Missing key nutrients prevents certain advanced nutrients or even higher levels of specific nutrients from doing their job because major imbalances can render those nutrients useless, less bioavailable, or unable to contribute what they could were there a sufficiency of the basic nutrients required to support all biochemical processes in the body. We have written much on this topic—please see the resources section (below) for more information.

The point is that without a plentiful supply of basic nutrients in ideal forms, which is exactly what is provided by foundational supplements (and almost never by diet alone), a person will remain vulnerable to many nutrient deficiencies. Nutrient deficiencies (especially when they are prolonged over time) can result in less than optimal health.

By simply providing optimal levels of all basic nutrients, foundational supplements support the body by covering its nutritional needs, not unlike insurance. Moreover, they are generally inexpensive (relative to conventional health care costs) even for the highest-quality supplements, such as HPDI formulas.

CONCLUSION

Foundational supplements remain fundamental for health. Nothing can replace them. Before starting single nutrients or condition-specific formulas, it is important to obtain a full complement of basic nutrients that support bodily function.

After basic nutrition is attained through foundational supplements, diet, and appropriate lifestyle changes, then other types of nutritional supplements (such as enhancement formulas and specific-condition formulas) may be added to form a complete nutritional supplement system.

Key Takeaways:

• More people are getting advanced forms of specific vitamins and minerals in supplement form, usually at the direction of their doctor or nutritionist

• Few people obtain a complete, high-potency multivitamin

• Fewer still consume high-quality forms of all basic nutrients (provided by good diet and foundational supplements)

• Adding a complete set of high-potency, foundational supplements (multivitamin, Vitamin C / antioxidant formula, essential fats, high-RNA superfoods), hydrogen, and gut health formulas) supports basic good health

• Poor dietary choices increase the need for nutritional supplements that can provide high levels of a wide range of essential nutrients

• Taking foundational supplements sporadically is not a good way to ensure you obtain adequate levels of the important nutrients you require daily

SOURCES & RESOURCES

Foundational Supplements Program

The Need for Foundational Supplements (.pdf)

HPDI BLOG ARTICLES

Amending the HPDI Foundational Supplements Program

Vitamin C / Antioxidants

PRO-C and Ultimate Protector – Comparison of Antioxidant Formulas

Questions and Answers about Ultimate Protector

The Amazing Healing Potential of Natural Nrf2 Activators

Ultimate Protector™: First Impressions

Ultimate Protector™ Brunswick Labs ORAC5.0™ Test Results

Preventing Free-Radical Damage Using Ultimate Protector™

Description and Comparison of ORAC Tests for Well Known Plant Ingredients and Ultimate Protector™

Ultimate Protector and the Role of Foundational Supplements for Health

Natural Phytochemical Nrf2 Activators for Chemoprevention

New Directions for Preventing Free Radical Damage

Ultimate Protector flyer (.pdf)

Review of Scientific Research on Oligomeric  Proanthocyanidins (OPC) by Dr. Hank Liers

Vitamin C – An Amazing Nutrient by Dr. Hank Liers

High-RNA Superfoods

Rejuvenate! Berries & Herbs: Ingredients for Optimal Nutrition

9 Things to Know About Rejuvenate!™ Superfoods

High-RNA Rejuvenate!™ Superfood

Rejuvenate! – The Original, High-RNA Superfood

Natural Phytochemical NRF2 Activators for Chemoprevention

DIETARY NUCLEIC ACIDS – DR. BENJAMIN S. FRANK, PART 1

DIETARY NUCLEIC ACIDS – DR. BENJAMIN S. FRANK, PART 2

Super-Tasty Morning Nutritional Drinks

PRODUCTS / SUPPLEMENTS

Hank & Brian’s Mighty Multi-Vite!

Multi Two (caps and tabs)

PRO-C (vitamin C / antioxidant formula)

Ultimate Protector™ Nrf2 Activator

Essential Fats Plus E

Rejuvenate!™ PLUS

Rejuvenate!™ (Original)

Rejuvenate!™ Berries & Herbs

Rejuvenate! Superfoods: Product Comparison

Hydrogen products

RESTORE

HPDI FOUNDATIONAL SUPPLEMENTS

Vitamin D3 PLUS

MYO-MAG (magnesium)

Warrior Sleep & Warrior products

Intestinal Rejuvenation Formula

Prescript-Assist probiotic (soil-based organisms)

CONTACT US:

You can reach HPDI by calling 1-800-228-4265, email Support(at)IntegratedHealth.com, or visit the retail website: IntegratedHealth.com

Health care professionals and resellers can apply for wholesale account, which includes access to the HPDI reseller website: HealthProductsDistributors.com. Email: Support(at)HealthProductsDistributors.com.