Rejuvenation Program: Part Six

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Foundational Elements in HPDI’s Master Rejuvenation Program

Fred Liers PhD rejuvenation programThe HPDI Rejuvenation Program provides practices, protocols, and recommendations proven over 26 years. It is a complete program to rejuvenate, regenerate, and boost vitality to body, mind, and spirit. It is especially helpful for those who want to restore health.

The program emphasizes establishing basic nutrition, foundational supplement formulas, and high-RNA Rejuvenate!™ superfoods and other sources of dietary nucleic acids. The program rests on six elements: 1) Attitude/Commitment, 2) Detoxification, 3) Preventing Toxicity, 4) Health Building Nutrition, 5) Building Powerful Immunity, and 6) Supporting Protocols.

The six foundational elements remain powerful individually, but act synergistically when combined to support optimal health. The results are greatly improved capabilities for your body to heal, regenerate, rejuvenate, and restore its vitality.

In Part Four of the Rejuvenation Program series, I presented key roles played by four foundational nutritional supplements, which I also refer to as “foundational” (or sometimes “core”) supplements. These nutritional supplements are critical to success in creating powerful health by establishing optimal nutrient status in the body. We regard foundational supplements to include 1) Multivitamins, 2) Antioxidants / Vitamin C formulas, 3) Essential Fats, and 4) Rejuvenate!™ High-RNA superfoods (and/or other sources of dietary nucleic acids).

The four types foundational supplements are the most important supplements regardless of what other supplements you take. We particularly recommend our HPDI supplement formulas, primarily because they incorporate the latest science, and provide the highest-purity and highest-quality nutrition, cutting-edge design, and uniquely effective ingredients (e.g., coenzyme form B vitamins). Perhaps most importantly, they are designed to work together synergistically as part of our system of foundational nutrition.

Our multivitamin formulas include Multi Two (tabs and capsules) Hank & Brians’ Mighty Multi-Vite!™, and the Mini Multi (contains no fillers, excipients, or additives). Our essential fats formulas include Omega Plus and Hank & Brian’s Essential Fats Plus E. Our Antioxidant / Vitamin C formulas include Ultimate Protector™PRO-C™, OPC-C™,  Buffered Vitamin C 1,000 (tabs) and Buffered C (powder).

Among the topics treated in Part Three of the Rejuvenation Program series, I discussed foods recommended in the HPDI Rejuvenation Program. Recommendations include consuming foods high in nucleic acids (RNA and DNA). High-RNA foods include many beans and legumes, vegetable soups (and broths), many fish (e.g., sardines) and seafoods, and high-purine vegetables like onions and spinach. These are wonderful foods for health. However, richer sources of nucleic acids include chlorella (ten times more RNA than sardines) and Rejuvenate!™ superfoods.

Rejuvenate!™ superfoods provide high levels of RNA not only because all of them (except Rejuvenate!™ Berries & Herbs and Rejuvenate! Strawberry-Peach Protein Plus) contain chlorella, but also because they include other high-RNA foods such as nutritional yeast, RNA extracts (from yeast), and chlorella growth factor (CGF) (an RNA-rich extract of chlorella). This allows for a broader spectrum of nucleic acids and for higher overall levels of nucleic acids per serving.

While Rejuvenate!™ superfoods provide high levels of nucleic acids (for rejuvenation, revitalization, and superior health), they also include supporting nutrients (e.g., d-ribose, coenzyme B vitamins) that facilitate efficient uptake and utilization of nucleic acids in the body, and thereby help to optimize their healing effects.

In fact, HPDI designs Rejuvenate!™ superfoods to include specific ingredients that leverage therapeutic benefits of nucleic acids and provide superior overall nutrition. For example, d-ribose (as mentioned above) is a rate-limiting nutrient for the uptake of nucleic acids. D-ribose is the molecular backbone of nucleic acids, and it is therefore needed in the body to utilize them. In short, the body uses nucleic acids most effectively when optimal amounts of d-ribose are readily available.

B-vitamins are known to significantly enhance the effects of nucleic acids. Rejuvenate!™ superfoods provide coenzyme forms of B vitamins, which are the natural forms most easily recognized (and used) in the body. The pioneering nucleic acid researcher Dr. Benjamin Frank showed that B vitamins increase certain beneficial effects of RNA during nucleic acid therapy with dietary nucleic acids. Because the body utilizes coenzyme form B vitamins most efficiently, the benefits of nucleic acids relating to B vitamin intake can be realized more rapidly.

While therapeutic levels of nucleic acids are desirable in themselves, the fact that Rejuvenate!™ superfoods provide valuable supporting nutrients means that the body will be better equipped to assimilate and use nucleic acids to support processes of rejuvenation. This can significantly improve health, naturally.

HPDI offers five versions of Rejuvenate!™, including Rejuvenate!™ (original greens), Rejuvenate!™ PRO, Rejuvenate!™ PLUS, and Rejuvenate!™ Berries & Herbs and Rejuvenate! Strawberry-Peach Protein Plus. Rejuvenate!™ PLUS and Rejuvenate!™ Berries & Herbs are the most comprehensive formulas our line. Both provide delicious taste, therapeutic levels of dietary RNA, nutrients that support the body’s use of nucleic acids (e.g., d-Ribose), a complete multivitamin, essential fats, fiber, and high levels of protein.

In Part Five in the Rejuvenation Program series, I presented what we consider the seven most important supplements for rejuvenation beyond foundational supplements. These include Coenzyme Q10 and Ubiquinol, Magnesium (including magnesium chloride and Myo-Mag), Hepa Plus, Nascent Iodine, the immune-supporting herb Echinacea, and Immune-Assist™ mushroom-polysaccharide complex. Each of these supplements plays a major role in our Rejuvenation Program.


In this month’s article, I discuss three supporting protocols, including the Garlic Program, Hydrotherapy Program, and Sauna Program. These are major supporting protocols in the Rejuvenation Program, which is our complete program for creating vitality and health. There are additional supporting protocols, which I will consider in forthcoming articles.



Garlic is one of the most effective and versatile therapeutic plants in the world. Indeed, it not only is a food, but also a proven medicinal herb, and supports powerful health via many modes of action. It has a long history of health-enhancing and culinary uses, making it an ideal example of a food that can be used for therapeutic purposes.

We include the use of garlic as its own supporting protocol because of its effectiveness in providing the body with a highly diverse range of benefits. For example, it acts as a powerful broad-spectrum antibiotic. It also exhibits antiviral, antifungal, and antiparasitic properties. In this regard, it has been proven to rid the body internally and externally of nearly any antigen or pathogen.

Garlic also is a superb source of the mineral sulfur. In addition, garlic is a rich source of organic selenium. Selenium is an important antioxidant and key component of the enzyme glutathione peroxidase.

There have been over one thousand research studies on garlic during the last 40 years [1]. These studies have investigated the following effects of garlic: 1) antibiotic effects, 2) cardiovascular effects (including cholesterol lowering), 3) anticancer effects, 4) effects on blood sugar, 5) effectiveness as a heavy metal antidote/chelator, 6) potential alleviation of intestinal problems, and 7) other biological and chemical effects.

Research studies show that garlic lowers serum cholesterol and triglycerides while raising HDL cholesterol (i.e., the “good” cholesterol). It reduces the “stickiness” of platelets, making blood circulation more efficient. In addition, it causes a mild reduction in blood pressure. This makes garlic an ideal component or adjunct in programs/regimens for heart health, cholesterol reduction, circulation (throughout the body), and blood pressure reduction.

As noted, garlic exhibits potent antibacterial, antiviral, antifungal, antiparasitic effects, and exerts action against organisms causing yeast infection. In this regard, it provides excellent support in programs/regiments that involve infections and for building immunity.

In addition, when regularly consumed, garlic is associated with lowered risk of stomach and colon cancer. In fact, garlic has been proven in hospitals and laboratories worldwide to destroy cancer and break up tumors. Garlic can be used externally an “herbal surgeon” (so use care when using it externally).

Considering all the beneficial effects of garlic from thinning blood to normalizing blood pressure and cholesterol levels, it becomes apparent that garlic benefits the entire body. Rather than targeting a single organ or health condition, it works systemically to improve the overall health. Garlic is therefore ideal both for improving specific conditions (i.e., the health of the heart and circulatory system) and helping to create and maintain excellent health. This partly relates to the fact that it acts a powerful preventive to counteract health concerns (e.g., elevated cholesterol) before they lead to major conditions (like heart disease).


Consume three (or more) large cloves of fresh, organic, raw garlic every day. Garlic can be eaten raw, swallowed whole, chopped up and mixed with food, or juiced with other vegetables. The best garlic is the hottest, and, of course, organic. Raw garlic is the most therapeutic, but cooked garlic will still provide certain benefits. Garlic supplements can be used whenever fresh garlic is not available or desirable, or as adjuncts to fresh garlic. Enterically coated garlic supplements provide the highest potency and the greatest total allicin potential.

Allicin is the component of garlic responsible for most of its health benefits. Allicin is formed when the garlic enzyme alliinase comes into contact with alliin (the principal active phytochemical/component in garlic). This occurs when garlic is chopped or crushed, as occurs when chewing. The more garlic is crushed, chopped, or chewed before it’s eaten, the greater the amount of allicin is formed. In addition to chewing it well, this means it may be beneficial to use a garlic press, food processor, or other kitchen gadget to crush, mince, or finely chop the garlic before you eat it.

If (or when) you cannot consume fresh, raw garlic, then supplements can ensure you get your daily dose. In this regard, it is important to note that stomach acids destroy alliinase. This means that garlic powders (in capsules) subjected to stomach acid are ineffective. Enteric coatings that break down in the small intestine at higher pH (but not under the acidic conditions of the stomach) are required to gain maximum benefit from a garlic supplement.

If you decide to take supplements, then look for a high-quality, enteric coated garlic supplement. There are several very potent products that are convenient, easy to use, and odorless. For example, try to find a 500 mg tablet providing 6,000 mcg (minimum total allicin potential) equivalent to 1,500 mg of fresh garlic.


Garlic, of course, has a long history of therapeutic use and has been studied extensively for decades. Yet modern research continues to discover additional benefits of garlic and reveals the mechanisms behind its therapeutic effects. For example, it was widely known that garlic provides powerful antioxidant protection. But the mechanism of its antioxidant activity was only recently shown to relate to sulfenic acids that form when allicin breaks down within the body [2].

Sulfenic acid acts far more powerfully and rapidly to quench free radicals than any known antioxidant. As allicin breaks down into its components, the sulfenic acids that form can immediately react with free radicals to neutralize them. The speed of this reaction is limited only by the rate at which the molecules come into contact. No other antioxidant substance reacts as rapidly as sulfenic acid from garlic.

What also surprised researchers is that garlic exhibits high antioxidant activity, but does not contain substances associated with high antioxidant activity, including proanthocyanidins (from grapes), catechins (from green tea), or other bioflavonoids. It is clear is that sulfenic acids in garlic largely account for its powerful antioxidant properties. In fact, sulfenic acids may be the most potent biological agents in terms of their capacity to prevent oxidation.

Another recent study indicates that sulfenic acids are not the only substances in garlic that acts as antioxidants. It was demonstrated that garlic significantly increases the activity of various important antioxidant enzymes, including superoxide dismutase [3]. Garlic also lowers blood levels of malondialdehyde (MDA), a key biomarker for lipid peroxidation. MDA levels provide a measurement of the levels of oxidation of fats in the body. The capacity for antioxidants in garlic to reduce lipid peroxidation indicates that garlic offers surprisingly powerful antioxidant protections that make it one of the healthiest foods available.

One of the greatest advantages of garlic is that its therapeutic benefits can be enjoyed alongside its delicious flavor than adds character to many different foods (especially if you like garlic). Individuals who do not enjoy the taste of garlic (or who wish to avoid any hint of “garlic breath”) can try a potent, enteric coated garlic supplement, such as One-A-Day Garlic Tabs.



Hot and cold showers are a very effective way to move the blood and create circulation. Once daily, take a complete hot and cold shower. You will start with hot water for 1 minute, then cold for one minute. Repeat this seven (7) times so the shower should last about fifteen minutes. If starting out with hot water is too intense for you, then start with warm water. Likewise, if your cold water is extremely cold, then start with slightly cool water. As your body adapts, you can adjust the water temperature both to make it hotter and/or colder. Ultimately, using water temperatures as extreme as you can tolerate will produce stronger therapeutic effects.

On a different occasion daily, you can re-take a complete hot and cold shower again, or do a partial one just applying the water directly an affected area where there is pain or dis-ease. While alternating hot and cold water during the shower, pay special attention to any affected area and massage it vigorously. If no shower is available to you, then alternate hot packs (e.g., a hot water bottle) and ice packs.


Alternating hot and cold showers effectively stimulates circulation and improves heath and healing. This is because alternating hot and cold temperatures to the body acts like a pump to drive circulation. It works like this. Hot water visibly brings blood flow to the surface of the skin. Cold water drives blood deep into the body (resulting in a pale complexion). Applying hot water again brings the blood to the surface, and then cold water drives it deep into tissues. After alternating hot and cold water seven times (for a total of seven complete “cycles”), your circulation will really be moving. This supercharges your circulation.

The key reason that improved circulation helps heal and regenerate the body is because an injured, weakened, or even sedentary body often lacks circulation in some or many areas. Increased circulation restores normal function. In addition, reduced circulation brings less oxygen and fewer nutrients to cells, and reduces the ability of the body to remove cellular wastes and detoxify.

An equally important reason improved circulation is critical for rejuvenation because improved circulation overcomes blockages. For example, an injured or dis-eased area may experience reduced circulation due to blockages of blood flow relating to many causes. For example, these causes may include damaged tissues, impaired vessels or capillary trauma, scarring, abnormal cell growth, clots, conditions that reduce and/or weaken blood cells, liver disease, anemia, and others.

Stimulating circulation with external means (i.e., alternating hot and cold water) helps the body overcome blockages and significantly increases blood flow. Because blockages reduce blood flow and contribute to dis-ease, the action of increasing circulation simultaneously acts to reduce or eliminate blockage, improve flow, and helps the body to heal, regenerate, and create powerful health.

The hydrotherapy program works well with other supporting protocols, especially the magnesium chloride baths that are part of the Magnesium Chloride program.



Sauna therapy is a safe, effective, and enjoyable modality that detoxifies and heals the body. Saunas have been widely by many civilizations and cultures, including the US in the 19th century. Sauna use reemerged in the US in the late 20th century as a means for removal of toxins from the body.

The popularity of saunas increased after the introduction of infrared saunas, which are more enjoyable for many individuals, and are more effective for detoxification. We highly recommend using saunas, especially far infrared saunas, for their powerful health benefits [4]. There are many brands of far infrared saunas available. We prefer the upright type that is usually constructed of wood.

Saunas are powerful for detoxification because they help eliminate organic chemicals, excess metals and minerals, biological toxins, and other sources of toxicity. A full exploration of how saunas detoxify and build health is beyond the scope of this article. However, I will address the unique capacities for detoxification facilitated by far infrared sauna therapy.


The far infrared (FIR) sauna is a very useful detoxification tool. Far infrared saunas provide all the benefits of conventional saunas, but add additional benefits, including deep tissue healing and enhancing the activity of water molecules in the body.

In a far infrared sauna, the radiation heats our bodies from the inside out (much as the sun does to our skin on a sunny day). The thermal effects within the deeper layers of tissue cause the blood vessels and capillaries to dilate, promoting increased circulation and removing metabolic wastes and toxins through sweating.

Infrared light also activates water molecules in the body by vibrating them at infrared frequencies. Vibrating water molecules become more active as they are ionized into hydrogen and hydroxide ions that release gases and other toxic materials. This is one means by which infrared light decouples toxins from water molecules in the body, and liberates them for elimination through skin.

The act of decoupling toxins from water molecules also reduces the surface tension of the body’s water to support hydration and tissue oxygenation. An additional response to infrared light is that cell mitochondria also increase energy (ATP) production, thereby raising the metabolic rate.

Infrared activation of water molecules in the body provides major benefits through multiple modes of action: facilitating cellular processes, increasing metabolism and energy, and liberation of toxins so they can be removed via the skin. These benefits exert reciprocal effects to allow the body’s detoxification processes to become increasingly effective.

For example, decoupling of toxins makes them available for removal; greater energy allows cells to process toxins more effectively; improved metabolism allows for faster excretion of toxins through skin. These synergistic effects mean that a far infrared sauna can induce far greater rates of detoxification than conventional saunas.

Far infrared saunas also demonstrate significantly increased detoxifying effects because the heat they generate can penetrate deeper tissues. A key benefit: when using a conventional sauna, it is estimated that sweat contains about 2% toxins and 98% water. In a far infrared sauna, the ratio increases significantly to 20% toxins and 80% water.

We recommend setting the sauna air temperature to about 125–135 degrees Fahrenheit and remain in the sauna between 20–35 minutes. Do this several times per week (or every day for three weeks for more intensive detoxification). As your body adapts to sauna therapy, you can gradually increase time spent in the sauna. However, always be aware of your limits, and do not push yourself beyond the point you can tolerate safely. Adjusting to higher temperatures and longer durations takes time.


Saunas improve the health of the body via multiple modes of action. These modes include: increased circulation, greater tissue oxygenation, improved delivery of nutrients to cells, deep muscle relaxation, and other benefits. However, one of the primary benefits of sauna therapy relates to detoxification of organic chemicals, excess metals and minerals, and biological toxins.

I discussed detoxification as a foundational element of rejuvenation in Part Two of the Rejuvenation Program series. Effective methods for removing toxins can be found in our Rejuvenation Program. These methods include protocols for detoxification, for example, a juicing program combined with certain herbs and supplements, including Rejuvenate!™ superfoods, Intestinal Rejuvenation Formula, Edible Earth, Nascent Iodine, and Hepa Plus (a liver-specfic herbal supplement).

My treatment of sauna therapy is no less relevant than other methods or modalities for detoxifying. Indeed, we include far infrared sauna therapy as one of the supporting protocols in our Rejuvenation Program precisely because of its effectiveness and ease of use. Skin is an amazing organ both for taking in nutrients (e.g., sunshine, air, transdermally applied magnesium chloride) and for eliminating toxins. As noted, sauna therapy leverages our capacity for eliminating toxins through skin to increase rates of removal. It is the modality of choice for removing certain toxins. When combined with other modalities (e.g., juicing and consuming therapeutic clays like Edible Earth), the rate of detoxification substantially increases.

Sauna therapy detoxifies from the body at least three major categories of toxins: 1) organic chemicals, 2) toxic or excess metals and minerals, and 3) biological toxins.


Tens of thousands of toxic chemicals exist in our environment. They make their way into our bodies, burden detoxification organs, impair cellular function, and damage health. Most of these chemicals are not tested for safety. They range from industrial and household chemicals (including petrochemicals) to various solvents, additives, preservatives, pesticides, herbicides, fluoride, chlorine, chemicals in fire retardants, and in metabolized wastes of pharmaceutical drugs found in the water supply, just to name a few. Some of the more common toxic chemicals include PCBs, trichloroethylene and volatile organic compounds (VOCs), formaldehyde, pthalates, and phenols (including bisphenol A). In addition, many of these toxic chemicals are endocrine (hormone) disruptors (xenoestrogens).

While most of toxic chemicals have not been tested for safety, it is often possible to test an individual for specific chemicals. However, testing is expensive, and testing for thousands of chemicals is impractical, even when tests exist. However, it is known that when tests are conducted, subjects typically show positive for about half of the chemicals in a given test. Yet, when testing indicates the presence of toxic chemicals in the body, the current medical system offers few options for detoxification. In this regard, sauna therapy is probably one the most effective modalities for helping to remove existing toxins.


Toxic metals and minerals/elements present another set of toxins that require detoxification. Like toxic chemicals, toxic metals are ubiquitous in the environment, persistent and highly damaging to biological systems, and often difficult to remove from the body. Toxic metals include lead, mercury, cadmium, aluminum, and arsenic. Other metals can become toxic depending on their form or deficiencies in other metals. These metals include iron, copper, manganese, and selenium. Common toxic minerals/elements include chlorine and fluoride, but can include excessive amounts of minerals required for good health.

Symptoms and conditions associated with metal and/or mineral toxicity are many and varied. These include weakened immunity, mental impairment, cognitive dysfunction/learning disabilities, hypothyroidism, diabetes, joint pain, cancer, and various behavioral and emotional problems. Far infrared saunas are particularly well suited for removing toxic metals and excess amounts of vital minerals.


Other toxins that can be cleared by sauna therapy include biological toxins. Biological toxins are often related to chronic infections, including powerful toxins released by bacteria and fungi. It is interesting that bodies weakened by exposure to toxic chemicals or metals are predisposed to chronic infection. Removal of toxic chemicals and metals through far infrared saunas will improve individuals’ capacity to fight infection. In addition, saunas address infection-related biological toxins directly by increasing circulation, heating the body, and employing other means that can reduce or eliminate chronic infections.


In general, saunas exhibit two phases in which distinct physiological effects occur. Distinguishing the two phases is important because it is necessary to experience both phases for maximum health benefits.

Whereas the first phase typically lasts for 10–30 minutes, inception of the second phase depends on various factors. These factors include how frequently an individual uses a sauna because as the body adapts, phase one time may decrease to ten minutes.

In the first phase, body temperature remains at about basal level and sweating is not profuse. The temperature of the body does not increase greatly because heat is dissipated by increased circulation, shunting of blood to surface tissues, and sweating. However, important effects of this phase include inhibition of the sympathetic nervous system, improved tissue oxygenation, dilation of peripheral blood vessels, muscle relaxation, and pain relief.

After 10 to 30 minutes, the body’s capacity to dissipate the sauna’s heat diminishes. The body shunts blood to surface tissues with greater force. There are increases in body temperature, heart rate, circulation, and sweating. In fact, body temperature may rise 1–4 degrees Farenheit (F). This sauna-induced hyperthermia provides many beneficial effects.

An important phase-two effect is hastening the death of weak cells, i.e., the destruction or disabling of relatively weaker cells and/or heat-sensitive cells. Examples of weakened cells that can be destroyed include cells 1) infected with viruses, 2) with damaged DNA, 3) holding radioactive minerals, 4) burdened with chemical toxins, 5) with high levels of toxic metals (e.g., mercury, lead, cadmium). In addition, other weak cells that can be destroyed during this phase include cancer cells, bacteria and spirochetes, as well as fungi and other parasites.

As I mentioned previously, a unique benefit of far infrared saunas is deep tissue healing. Far infrared radiant energy penetrates skin and heats tissues to a depth of approximately 1.5 inches. This greatly facilitates sweating when compared to conventional hot air saunas that heat only the surface of the body. This deep penetration of heat allows sweating to occur at lower ambient temperatures. For many individuals, this is an advantage that makes far infrared saunas relatively more comfortable while offering equal or greater therapeutic effects.


Supporting protocols are a major part of HPDI’s Rejuvenation Program. These protocols work together powerfully with the other foundational elements of the Rejuvenation Program to create health. Indeed, they often work directly to detoxify, prevent toxicity, boost immune function, leverage the benefits of a solid nutrition program, and build vitality.

You may not always be able to follow all supporting protocols in our Rejuvenation Program, yet the more you can do, the better. Because each supporting protocol supports the body in a different way, the cumulative effect is to create favorable conditions in the body that support, build, and maintain great health, naturally.

When you combine the supporting protocols with the other primary elements in the Rejuvenation Program, the results speaks for themselves: rejuvenation, regeneration, healing, and health. We hope you benefit from our recommendations.

[1] An in-depth reference edition that presents many findings from decades of garlic research: Garlic: The Science and Therapeutic Application of Allium sativum L. and Related Species. 2nd ed. Heinrich Koch, PhD, M. Pharm. ed. and Larry D. Lawson, PhD. Williams and Wilkins, 1996. Trans. of Knoblauch, 1988.
[2] Vaidya, Vipraja, Keith Ingold, and Derek Pratt. 2009. “Garlic: Source of the Ultimate Antioxidants – Sulfenic Acids.” Angewandte Chemie 2009, 121 (1): 163-166.
[3] “Health Benefits Of Garlic Traced to Acid Produced In Decomposing Organic Compound,” Medical News Today, Feb. 2nd, 2009.
[4] For additional information, see Sauna Therapy for Detoxification and Healing by Lawrence Wilson, MD. Wilson Consultants, 2006.

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