Rejuvenation Program: Part Five

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Fred Liers PhD rejuvenation programThe HPDI Rejuvenation Program provides practices, protocols, and recommendations proven over 26 years. It is a complete program to rejuvenate, regenerate, and boost vitality to body, mind, and spirit. It is especially helpful for those who want to restore health.

The program emphasizes establishing basic nutrition via foundational nutritional supplement formulas, including high-RNA Rejuvenate!™ superfoods and other sources of dietary nucleic acids. The program rests on six elements: 1) Attitude/Commitment, 2) Detoxification, 3) Preventing Toxicity, 4) Health Building Nutrition, 5) Building Powerful Immunity, and 6) Supporting Protocols.

The six foundational elements remain powerful individually, but act synergistically when combined to support optimal health. The results are greatly improved capabilities for your body to heal, regenerate, rejuvenate, and restore its vitality.


In Part Four of the Rejuvenation Program series, I presented key roles played by four foundational nutritional supplements, which sometimes are referred to as “core” supplements. These supplements are critical to success in creating powerful health by establishing optimal nutrient status in the body. We at HPDI consider foundational supplements to include: 1) high-potency multivitamins, 2) essential fats, 3) Vitamin C / antioxidant formulas, and 4) Rejuvenate! high-RNA superfoods.

These four types of foundational formulas are the most important nutritional supplements regardless of what other supplements you take. In particular, we recommend our HPDI supplement formulas, primarily because they incorporate the latest science, and provide the highest-purity and highest-quality nutrition, cutting-edge design, uniquely effective ingredients (e.g., coenzyme form B-vitamins). Perhaps most importantly, they have been designed to work together synergistically as part of our system of foundational nutrition.

Here are some of HPDI’s most effective foundational formulas:

Multivitamin formulas include multivitamins Multi Two (tab and capsules) Hank & Brians’ Mighty Multi-Vite!, and our Mini Multi (contains no fillers, excipients, or additives). Our essential fats formulas include Omega Plus and Hank & Brian’s Essential Fats Plus E. Our Antioxidant and/or Vitamin C formulas include Ultimate Protector™PRO-C™, OPC-C™, and Buffered C (tabs and powder).

Recall that in Part Four of the Rejuvenation Program series, I also discussed foods recommended in our Rejuvenation Program. Our recommendations include consuming foods high in nucleic acids (RNA and DNA). RNA-rich foods include chlorella and Rejuvenate!™ superfoods. Rejuvenate! superfoods provide therapeutic levels of nucleic acids to support optimal rejuvenation, revitalization, and health. They also provide unique supporting nutrients (e.g., d-ribose, coenzyme B vitamins) that maximize utilization and healing effects of dietary nucleic acids.

HPDI offers five versions of Rejuvenate!, including Rejuvenate! (original greens), Rejuvenate! PRO, Rejuvenate! PLUSRejuvenate! Berries & Herbs and Rejuvenate! Strawberry-Peach Protein Plus. Rejuvenate! PLUS and Rejuvenate Berries & Herbs are the most comprehensive in the line. Both provide delicious taste, therapeutic levels of dietary RNA, nutrients that support the body’s use of nucleic acids, a complete multivitamin, essential fats, and high levels of protein (except Berries & Herbs contains no greens).


The four foundational supplements (multivitamins, essential fats, Vitamin C, and Rejuvenate! superfoods) are primary. They are needed to build health, especially because they provide significant nutrition and support detoxification. You can count on these supplements to provide a solid foundation for any nutritional supplement program.

Now I’ll discuss the most important supplements that can be critical for building health beyond (i.e., in addition to) the four foundational supplements. That is, I’ll consider supplements in the “next tier” in terms of importance in our Rejuvenation Program.

There are many “non-foundational” nutritional supplements (enhancements, add-ons, and/or specific-condition formulas) that can play important roles in building health. However, I will focus on seven supplements we find most useful in supporting the four foundational supplements (multivitamins, essential fats, Antioxidants / Vitamin C formulas, and Rejuvenate!™ high-RNA superfoods) to rejuvenate the body. These seven supplements have proven themselves in our Rejuvenation Program, and represent the next level of importance for supplements for rejuvenation.



Coenzyme Q10 (CoQ10) is an important nutrient that is well known to boost cellular energy and acts as a powerful antioxidant. The primary function of this enzyme is to allow mitochondria to convert food metabolites (from the digestive process) into energy for cells. The body produces this enzyme, which is found in all cells, and which is especially abundant in heart, liver, and immune system.

CoQ10 is a fat-soluble antioxidant that has many other functions and provides many benefits in the body. It protects and regenerates Vitamin E in cell membranes. CoQ10 also has been shown to stimulate the body’s immune system.

When essential levels of CoQ10 are allowed to decline, the body’s vital organs and systems cannot meet their energy requirements. The inevitable results are major ill health and disease states.

Advancing age causes the body gradually to lose its innate ability to produce CoQ10. Improper nutrition and/or maldigestion also can reduce the body’s ability to generate the needed amounts of CoQ10. Dosages in the range of 50-300 mg have been reported effective in cases of heart disease, fatigue, and immune deficiency. Numerous studies have indicated that supplemental CoQ10 in the amounts of 30-100 mg can be helpful when gums need to be strengthened.

When individuals have low energy levels, CoQ10 boosts energy (ATP) production in cells and thereby provides greater levels of energy to the entire body.

CoQ10 as ubiquinone is an oxidized form of ubiquinol. Ubiquinol is the reduced form of CoQ10 and is the form that is primarily used in the body. In younger (i.e., less than 40 years of age) and healthy individuals, the body readily makes ubiquinol from ubiquinone. Because ubiquinone costs about half as much as ubiquinol, it is more cost-effective for young or healthy individuals to take ubiquinone.

Our CoQ10 Plus (100 mg) product contains 100 mg of ubiquinone along with the other fat-soluble vitamins E and A (as beta-carotene). This combination of antioxidants gets carried in the blood on lipoproteins and acts as a very powerful antioxidant. This combination also prevents crystallization of the CoQ10 in the softgel thereby keeping it bioavailable.

For those over the age of 40 or with significant health issues, CoQ10 in the form of ubiquinol is much more effective, and in many cases necessary. In this case, we highly recommend our Ubiquinol 50 product that contains 50 mg of ubquinol. For enhanced absorption and stability (i.e., to prevent crystallization and oxidation), Ubiquinol-50 also contains d-limonene oil (emulsifier), caprylic acid, capric acid, and alpha-lipoic acid.

CoQ10 (as ubiquinone) and/or Ubiquinol can play a major role in supporting rejuvenation by increasing cellular energy (ATP) production. Users often notice the difference immediately or shortly after starting to supplement with these potent, natural energy boosters.


Magnesium is critical for rejuvenating the body. In fact, it’s so important, we’ve developed an entire magnesium protocol for topically applied magnesium chloride (oil, flakes, and gel) (and I will address the topic transdermal magnesium therapy in an upcoming article). However, today I will discuss the oral magnesium supplement we recommend most highly.

While many of body’s needs for magnesium can be well met with topical magnesium chloride, certain applications (including our Rejuvenation Program itself) make excellent use of a specific oral magnesium supplement known as Myo-Mag. Myo-Mag is simultaneously an energizer (boosts celluar energy) and a relaxer (relaxes muscles) and rapidly boosts magnesium levels.

Myo-Mag contains ingredients known to participate in ATP production in the body. One capsule contains 100 mg of magnesium and 440 mg of l-malic acid. Whereas magnesium plays a critical role in key enzymatic reactions for both aerobic and anaerobic glycolysis, L-malic acid is a Kreb cycle intermediate compound intricately involved in the production of energy (as ATP). Research indicates that when there is increased demand for ATP, there is also an increased demand and utilization of both magnesium and malic acid.

Myo-Mag includes Vitamins B1 and B2 both in standard and phosphorylated coenzyme forms and Vitamin B6 in its phosphorylated coenzyme form only. These B vitamins are involved in many steps in energy production processes. Myo-Mag also provides manganese (because high levels of magnesium can deplete the body of manganese), magnesium carbonate (a malic acid buffer), and glycine as the carrier for a portion of the magnesium and for the manganese. Glycine is a carrier of magnesium in the blood and therefore can reduce the tendency to loosen stools for which other forms of magnesium are noted.

We have found that Myo-Mag is a critical supplement for individuals experiencing fibromyalgia, multiple chemical sensitivity, chronic fatigue syndrome, diabetes, hypertension, and other conditions of low energy. In addition, we often recommended Myo-Mag for athletes just prior to intense exercise in order to keep them in an aerobic energy state for longer periods of time. Under hypoxic (i.e., low oxygen) conditions, Myo-Mag can support greater anaerobic energy production. Many of our customers have used Myo-Mag to reduce muscle cramping.


One of six foundations in our Master Rejuvenation Program is detoxification. Indeed, rejuvenation of the body requires support for detoxification of the body, including liver detoxification. For this reason, we offer specific recommendations and supporting protocols for detoxification.

Many supplements we recommended in our Rejuvenation Program support detoxification via increased energy production (e.g., see Nascent Iodine and Myo-Mag). Yet, we also know how vital direct support for the liver can be for health. We designed Hepa Plus with the specific purpose of supporting healthy liver function, including detoxification.

Hepa Plus is a synergistic formula containing milk thistle (Silybum marianum) extract standardized to greater than 80 percent silymarin, dandelion root extract 4:1, alpha lipoic acid, n-acetyl l-cysteine (NAC), thiamin diphosphate (cocarboxylase), ornithine alpha-ketoglutarate, glycine, taurine, and minerals molybdenum and selenium.

The liver plays a major role in metabolism and has a number of functions in the body, including detoxification, glycogen storage, decomposition of red blood cells, plasma protein synthesis, and hormone production. It produces bile, an alkaline compound which aids in digestion via the emulsification of lipids. Its highly specialized tissues also regulate a wide variety of high-volume biochemical reactions, including the synthesis and breakdown of small and complex molecules, many of which are necessary for normal vital functions. Simply put, the liver is necessary for survival. For example, there is currently no means to compensate for complete loss of liver function. Therefore, it is essential to maintain liver health both to sustain life and to create optimal health in a toxic world.

Extensive research has shown that silymarin (the major component of milk thistle extract) exerts both a protective and a restorative effect on the liver and can stimulate the growth of new liver cells to replace old damaged cells. Studies have shown that dandelion root enhances the flow of bile, improving such conditions as liver congestion, bile duct inflammation, hepatitis, gallstones, and jaundice. Lipoic acid is an important nutrient that enhances metabolism, acts both as a water-soluble and fat-soluble antioxidant, and is a toxic metal chelator (including chelation of free iron, copper, cadmium, mercury, and lead). Thiamin diphosphate (cocarboxylase) is a coenzyme form of Vitamin B1 and is especially helpful for impaired liver function.

Other nutrients in Hepa Plus include NAC, which is effective for increasing liver concentrations of glutathione, a critically important antioxidant in the liver claimed to be responsible for about 60% of the liver’s detoxification processes. Glycine and taurine play important roles in Phase II liver detoxification pathways. Ornithine plays a key role in the urea cycle and allows the liver to eliminate the buildup of toxic levels of ammonia. Molybdenum and selenium are essential minerals for the synthesis of enzymes that support liver detoxification.

HPDI designed Hepa Plus as your powerful ally for building and maintaining liver health because  optimal liver function is critical to detoxification and successful rejuvenation. When liver function is restored and/or improved and thereby brought into a state of health, your body’s overall capacity to heal and rejuvenate becomes much greater. Because nutrients that help maintain peak liver function play important roles in our Rejuvenation Program, Hepa Plus is the supplement we recommend most highly for direct liver support, as it provides nutrients critically needed for it.


Nascent Iodine is a unique, ideal form of iodine that is rapidly absorbed and used by the body when taken as a nutritional supplement. It is associated with a wide range of benefits, not limited to supporting thyroid function and regulating metabolism, boosting energy levels (when iodine is deficient), supporting and maintaining detoxification systems and processes, supporting immune system function, fighting infections (natural antiseptic), and many other healthy benefits. Because of its antiseptic properties, it also can be used effectively to purify water for drinking. One drop provides 400 micrograms of Nascent Iodine in a base of organic grain alcohol.

More than 90% of Americans suffer from a deficiency of iodine. There are many causes for widespread deficiency among the population. Significant factors include diets lacking in ocean fish or sea vegetables (e.g., seaweeds), high intakes of toxic bromine (which is added to commercial breads and baked goods), and vegetarian or vegan diets (see more below), all of which can contribute to less than optimal levels of iodine.

Moreover, it is known that toxic halides, including chlorine, fluorine (e.g., fluoride in toothpaste), and bromine (e.g., in breads) compete for uptake with iodine in the body, and thereby contribute to iodine deficiency. Iodine deficiency can lead to the development of many adverse health conditions (and a wide variety of symptoms) because the entire body (i.e., all organ systems) depends upon iodine for the critical roles it plays energy production, healthy metabolism, and overall support of health. Nascent Iodine helps you transition from state of iodine deficiency to achieving optimal iodine levels.

Nascent Iodine biochemically is consumable iodine in an atomic form rather than a molecular form. It is a highly bioavailable, pure atomic iodine supplement in an energized state. This “charged” state is held by the atom until diluted in water and consumed, whereupon it gradually loses energy over a two to three hour span. During this time, the body recognizes Nascent Iodine as identical to the iodine used by the thyroid, and therefore it is absorbed effortlessly. This form of iodine is unique and well known to offer beneficial effects unlike any other form of iodine. In fact, Nascent Iodine is the most easily assimilated iodine available.


A healthy immune system is required for rejuvenation. Yet, often it is the immune system itself that requires rejuvenating to bring it to a level where it can better support rejuvenation of the entire body. Our Rejuvenation Program therefore builds the immune system and includes supplement recommendations and supporting protocols to accomplish that goal. Two of the most important immune building supplements we recommend are Echinacea (an immune enhancing herb) and Immune-Assist (a six-mushroom complex that provides polysaccharides that provide a wide range of health benefits).

Echinacea is one of the most powerful herbs known for boosting the immune system. Research shows that echinacea boosts immunity, prevents infection, and helps reduce the duration of illness. It also helps promote healing, has antiseptic and anti-inflammatory qualities, and stimulates the nervous system. It is an amazingly versatile herb.

Echinacea can be taken internally and applied externally to fight bacterial infections. It can also be used internally to lower fever and reduce allergic reactions. It is effective in fighting infectious conditions, including influenza, common colds, candida, herpes, and respiratory infections. In combination with other herbs it may be used for infections in any area of the body. For example, in combination with yarrow or bearberry it will effectively stop cystitis (bladder infection).

You can make your own echinacea tincture in a glass mason jar using fresh organic or wildcrafted echinacea roots, leaves, and seeds (available from Pacific Botanicals, 541-479-7777) soaked in vodka. Soak the herbs for several weeks in enough vodka to see 1/3 liquid above the solids at the top of the jar). Shake once or twice daily. After three to four weeks, strain through cheesecloth or a cotton towel into a large bowl, and then pour the filtered Echinacea tincture into the glass mason jar and/or dropper bottles. Use two droppers full (about 70 drops) of tincture four times daily.


Rejuvenation requires strong a strong immune system. While echinacea can provide a significant boost to immunity, there are other immune-building supplements that exert powerful effects. One of the best (and one we highly recommend) is Immune-Assist™, a unique mushroom-derived polysaccharide complex in a vegetarian capsule.

Immune-Assist™ Daily Formula is a new type of dietary supplement. It contains more than 200 different polysaccharides, derived from enzymatic breakdown of organic material derived from six different species of medicinal mushrooms. These include the species Agaricus blazei, Cordyceps sinensis hybrid, Lentinula edodes (shiitake), Grifola frondosa (maitake), Ganoderma lucidum (reishi), and Coriolus versicolor. Immune Assist™ contains 500 mg per vegetarian capsule and is made in America using only USDA-certified organic materials.

Scientific research shows that medicinal mushrooms grown on vegetable sources (including millet, rice bran, buckwheat, barley, etc.) activate an enzymatic process whereby complex cross-linked polysaccharides from these vegetable sources convert to biologically active immunomodulators (a.k.a., “biological response modifiers”). The polysaccharides produced from this process are powerful immune system stimulators that are effective and safe. For this reason, Immune Assist™ and other mushroom supplements are growing in popularity among health-minded indivduals.

Immune-Assist™ consistently and effectively boosts immune system function in the following ways: 1) stimulates cytokine (IL-2, IL-12, Tumor Necrosis Factor (TNF), and Interferon) production, which stimulates immune function, 2) increases Natural Killer (NK) cell activity against diseased cells, 3) increases the formation of explosive granules within NK cells, 4) increases the number and the activity of lymphocytes, specifically increasing T cells, 5) increases Interferon levels, which inhibits the replication of viruses and stimulates NK cell activity, and 6) increases the formation of TNF, a group of proteins that help destroy cancer cells.

Applications for Immune Assist™ include: 1) recurrent infections, such as colds, flu, and parasites, 2) gum disease, 3) heart disease, 4) peptic ulcer, 5) cancers, 6) slow healing wounds, 7) digestive problems, 8) AIDS, 9) hepatitis, 10) multiple sclerosis, and 11) autoimmune illnesses. Immune Assist™ has not exhibited side effects and is completely non-toxic even after years of use at therapeutic levels.

The importance of a strong, adaptable immune system cannot be underestimated, especially in the context of building (or rebuilding) health and for successful rejuvenation. While there are other useful immune building supplements (e.g., garlic, olive leaf extract), both echinacea and Immune Assist™ have proven highly effective for boosting immunity as part of a complete program for rejuvenation.


It is vital to take the four foundational nutritional supplements, which include a high-quality multivitamin formula, essential fats, an Antioxidant/Vitamin C formula, and a high-RNA superfood (e.g., Rejuvenate!™ superfoods) as part of a complete program of rejuvenation because the nutrients they provide remain foundational to health. Yet, optimal results usually depend on additional supplements both building on the nutrition provided by the foundational nutritional supplements and providing unique benefits beyond foundational nutrition. I have described seven of the most important additional supplements you can take for this purpose: CoQ10 + (100 mg) (as ubiquinone) or Ubiquinol-50, Myo-Mag, Hepa Plus, Nascent Iodine, Echinacea, and Immune Assist.

When you combine solid basic nutrition and foundational nutritional supplements with a combination of additional supplements right for you, you can expect results far exceeding what is possible for health when taking either foundational nutritional supplements, or additional supplements by themselves. The synergistic effects of this combination can transcend the effects of the individual supplements. Therefore, significant synergy results from combining the four foundational supplements with other supplements that optimize biological function, boost cellular energy (as ATP), enhance immunity, support detoxification processes, and help create powerful health from the inside-out.

It is evident that supplements by themselves are no replacement for the right attitude, healthy diet, detoxification, proper exercise, meditation, and other elements in our Rejuvenation Program. However, when the proper supplements are combined with other elements in the program, the supplements play a critical role in creating health and supporting your regeneration and rejuvenation.

Following the best practices generally produces the best results. This is especially true when establishing superior nutrition that can powerfully support rejuvenation and create sustainable health. This is why we at HPDI suggest first establishing a foundation for good health using foundational nutritional supplements, and then recommend adding specific additional supplements that build on your nutrient foundation in order to facilitate and optimize processes of regeneration and rejuvenation.


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