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BENEFITS OF GINKGO BILOBA EXTRACT

Dr. Hank Liers PhD gingko biloba extractHealth Products Distributors, Inc. (HPDI) has been carrying high-quality standardized Ginkgo Biloba extract (24/6) for more than 20 years. Ginkgo biloba extract is one of the best-selling herbal supplements in the United States and Europe because of its health benefits. Yet, because of severe price increases in ginkgo extract during the last few years, HPDI’s inventory was depleted. However, the price has now been greatly reduced for high-quality material—and we have inventory back in stock.

Ginkgo Biloba Tree

Ginkgo Biloba Tree

Ginkgo biloba has a long history of use (over thousands of years) in treating memory issues and blood disorders. Today, It is best known as a way to keep memory sharp. Laboratory studies have shown that Ginkgo biloba improves blood circulation by opening up blood vessels and making blood less sticky. Research studies also show that it is a powerful antioxidant.

Based upon these properties, Ginkgo biloba may improve blood vessel and eye health. Research has clearly shown that Ginkgo Biloba helps with dementia and poor circulation in the body. It also protects memory in older adults.

TECHNICAL DATA

Ginkgo leaves contain flavonoids and terpenoids, which are both antioxidants. In your body, harmful free radical substances build up as you age and may contribute to a range of health issues. The antioxidants found in Ginkgo biloba help to neutralize free radicals, and prevent them from damaging DNA and other cellular structures.

Leaves of Ginkgo Biloba Tree

Leaves of Ginkgo Biloba Tree

Chemical constituents: Ginkgo biloba leaf contains a complex mixture of flavonoids including: quercetin, kaempferol, isorhamnetin and other glycosides. It also contains unique diterpenes including ginkgolides A, B, C and J, sesquiterpene bilobalide, and other natural compounds that contribute in a synergistic manner to the beneficial actions of Ginkgo biloba.

Our GINKGO BILOBA extract contains only the highest-quality 50:1 extract of ginkgo biloba standardized to 24% minimum ginkgoflavonglycosides and 6% minimum combined ginkgolides A, B, C, and bilobalide. Each capsule contains 120 mg of the extract and their are 60 capsules in a bottle. Other ingredients include: microcrystalline cellulose, HPMC (vegetarian capsule), and silica. The ginkgolic acid content of the current production run is is 1.36ppm.

Here is the Certificate of Analysis of our current run of Ginkgo Biloba.

Ginkgo Biloba extract

Ginkgo Biloba 120 mg

 

SPECIFIC BENEFITS: GINKGO BILOBA EXTRACT

Reduces Conditions of Dementia: Scientific literature suggests that Ginkgo biloba extract benefits people experiencing cognitive decline, including those with dementia of Alzheimer’s disease (AD). Certain studies have found Ginkgo biloba can help improve cognitive performance and memory in both older and younger adults but might be especially useful for age-related mental decline.

Improves Concentration: Research shows that Ginkgo biloba extract can help combat poor concentration, reverse cognitive decline and and heal fatigue. It’s even useful for helping to treat cerebral insufficiency — a condition characterized by chronically low concentration, confusion, decreased physical performance, fatigue, headaches and mood changes.

Helps With ADHD: Some studies using therapies that include Ginkgo biloba have found relief and improved concentration for people with ADHD symptoms. And because it can improve concentration, memory and task performance, it may also reduce symptoms in people with dyslexia. There is also some evidence that ginkgo biloba can help reduce symptoms of autism, making it a potential autism natural treatment.

Helps with Headaches and Migraines: Ginkgo biloba can be an effective way to naturally reduce frequent headaches and the rate and severity of migraines because it reduces pain, increases blood vessel dilation and combats stress that can trigger problems. Headaches may be triggered by stress, fatigue, poor posture, drugs, low blood sugar, hormones, constipation, allergies, eyestrain, and nutritional deficiencies. The amazing benefits that ginkgo has on stress and fatigue is associated with its ability to lessen headache tension.

Helps With Anxiety and Depression: For those with nervousness, depression or mood swings, Ginkgo biloba extract can be helpful. Research suggests Ginkgo biloba benefits the body’s ability to handle stressors and counteracts the effects of high levels of stress hormones, like cortisol and adrenaline.

Ginkgo biloba is considered to be an adaptogenic herb that naturally raises the body’s ability to cope with stress. It can be especially helpful for people with generalized anxiety disorder (GAD) and possibly seasonal depression, panic attacks and social phobias.

Reduces Symptoms of Asthma: Studies have found Ginkgo biloba extract can reduce asthma-related symptoms. Because it lowers inflammation, improves antioxidant activity and positively effects nerve functioning, people have reported less trouble breathing when taking Ginkgo biloba.

Alleviates Symptoms of PMS: Early research has shown positive effects of taking Ginkgo biloba on reducing PMS symptoms, including mood swings, headaches, anxiety, fatigue and muscle pain. It also may have beneficial effects on mood and cognition in postmenopausal women and can help improve similar symptoms.

Helps Maintain Vision and Eye Health: Ginkgo biloba appears to be beneficial for eye health since it improves blood flow to the eyes and prevents free-radical damage that can affect the cornea, macula and retina. It can be especially beneficial for older adults in preserving vision and lowering UV damage or oxidative stress to eye tissue.

Improves Libido: Ginkgo biloba has positive effects on hormonal balance — particularly serotonin levels, blood pressure and circulation. This implies that it may help those dealing with erectile dysfunction and low libido. Ginkgo biloba has the potential to dilate blood vessels and improve blood flow to the genitals, which is important for reproductive health.

Helps Heal Hemorrhoids: Some studies have found that Ginkgo biloba helps those experiencing painful hemorrhoids, that cause swelling, pain and bleeding related to an increase in pressure on the veins of the anus and rectum. Ginkgo biloba may lower pain, improve pain tolerance and reduce inflammation, which may stop bleeding associated with hemorrhoids.

GINKGO BILOBA RESEARCH SUMMARY

Provided below are abstracts from some recent meta-analysis studies that document the effectiveness of Ginkgo biloba on mental health.

(ABSTRACT 1)
Tan MS, Yu JT, Tan CC, Wang HF, Meng XF, Wang C, Jiang T, Zhu XC, Tan L

Efficacy and adverse effects of ginkgo biloba for cognitive impairment and dementia: a systematic review and meta-analysis.

In: J Alzheimers Dis. 2015;43(2):589-603. doi: 10.3233/JAD-14083

Research into Ginkgo biloba has been ongoing for many years, while the benefit and adverse effects of Ginkgo biloba extract EGb761 for cognitive impairment and dementia has been discussed controversially.
OBJECTIVE: To discuss new evidence on the clinical and adverse effects of standardized Ginkgo biloba extract EGb761 for cognitive impairment and dementia.
METHODS: MEDLINE, EMBASE, Cochrane, and other relevant databases were searched in March 2014 for eligible randomized controlled trials of Ginkgo biloba EGb761 therapy in patients with cognitive impairment and dementia.
RESULTS: Nine trials met our inclusion criteria. Trials were of 22-26 weeks duration and included 2,561 patients in total. In the meta-analysis, the weighted mean differences in change scores for cognition were in favor of EGb761 compared to placebo (-2.86, 95%CI -3.18; -2.54); the standardized mean differences in change scores for activities in daily living (ADLs) were also in favor of EGb761 compared to placebo (-0.36, 95%CI -0.44; -0.28); Peto OR showed a statistically significant difference from placebo for Clinicians’ Global Impression of Change (CGIC) scale (1.88, 95%CI 1.54; 2.29). All these benefits are mainly associated with EGb761 at a dose of 240 mg/day. For subgroup analysis in patients with neuropsychiatric symptoms, 240 mg/day EGb761 improved cognitive function, ADLs, CGIC, and also neuropsychiatric symptoms with statistical superiority than for the whole group. For the Alzheimer’s disease subgroup, the main outcomes were almost the same as the whole group of patients with no statistical superiority. Finally, safety data revealed no important safety concerns with EGb761.
CONCLUSIONS: EGb761 at 240 mg/day is able to stabilize or slow decline in cognition, function, behavior, and global change at 22-26 weeks in cognitive impairment and dementia, especially for patients with neuropsychiatric symptoms.

(ABSTRACT 2)
Amieva H1, Meillon C, Helmer C, Barberger-Gateau P, Dartigues JF.

Ginkgo biloba extract and long-term cognitive decline: a 20-year follow-up population-based study.

In: PLoS One. 2013;8(1):e52755. doi: 10.1371/journal.pone.0052755. Epub 2013 Jan 11

BACKGROUND: Numerous studies have looked at the potential benefits of various nootropic drugs such as Ginkgo biloba extract (EGb761®; Tanakan®) and piracetam (Nootropyl®) on age-related cognitive decline often leading to inconclusive results due to small sample sizes or insufficient follow-up duration. The present study assesses the association between intake of EGb761® and cognitive function of elderly adults over a 20-year period.
METHODS AND FINDINGS: The data were gathered from the prospective community-based cohort study ‘Paquid’. Within the study sample of 3612 non-demented participants aged 65 and over at baseline, three groups were compared: 589 subjects reporting use of EGb761® at at least one of the ten assessment visits, 149 subjects reporting use of piracetam at one of the assessment visits and 2874 subjects not reporting use of either EGb761® or piracetam. Decline on MMSE, verbal fluency and visual memory over the 20-year follow-up was analysed with a multivariate mixed linear effects model. A significant difference in MMSE decline over the 20-year follow-up was observed in the EGb761® and piracetam treatment groups compared to the ‘neither treatment’ group. These effects were in opposite directions: the EGb761® group declined less rapidly than the ‘neither treatment’ group, whereas the piracetam group declined more rapidly (β = -0.6). Regarding verbal fluency and visual memory, no difference was observed between the EGb761® group and the ‘neither treatment’ group (respectively, β = 0.21 and β = -0.03), whereas the piracetam group declined more rapidly (respectively, β = -1.40 and β = -0.44). When comparing the EGb761® and piracetam groups directly, a different decline was observed for the three tests (respectively β = -1.07, β = -1.61 and β = -0.41).
CONCLUSION: Cognitive decline in a non-demented elderly population was lower in subjects who reported using EGb761® than in those who did not. This effect may be a specific medication effect of EGb761®, since it was not observed for another nootropic medication, piracetam.

(ABSTRACT 3)
Zhang HF, Huang LB, Zhong YB, Zhou QH, Wang HL, Zheng GQ, Lin Y

[An Overview of Systematic Reviews of Ginkgo biloba Extracts for Mild Cognitive Impairment and Dementia.

In: Front Aging Neurosci. 2016 Dec 6;8:276. doi: 10.3389/fnagi.2016.00276. eCollection 2016

Ginkgo biloba extracts (GBEs) have been recommended to improve cognitive function and to prevent cognitive decline, but earlier evidence was inconclusive. Here, we evaluated all systematic reviews of GBEs for prevention of cognitive decline, and intervention of mild cognitive impairment (MCI) and dementia. Six databases from their inception to September 2015 were searched. Ten systematic reviews were identified, including reviews about Alzheimer’s disease (n = 3), about vascular dementia (n = 1), about both Alzheimer’s disease and vascular dementia (n = 2), about Alzheimer’s disease, vascular dementia and mixed dementia (n = 3), and a review about MCI (n = 1). Based on the overview quality assessment questionnaire, eight studies were scored with at least 5 points, while the other two scored 4 points and 3 points, respectively. Medication with GBEs showed improvement in cognition, neuropsychiatric symptoms, and daily activities, and the effect was dose-dependent. Efficacy was convincingly demonstrated only when high daily dose (240 mg) was applied. Compared with placebo, overall adverse events and serious adverse events were at the same level as placebo, with less adverse events in favor of GBE in the subgroup of Alzheimer’s disease patients, and fewer incidences in vertigo, tinnitus, angina pectoris, and headache. In conclusion, there is clear evidence to support the efficacy of GBEs for MCI and dementia, whereas the question on efficacy to prevent cognitive decline is still open. In addition, GBEs seem to be generally safe.

(ABSTRACT 4)
Hashiguchi M, Ohta Y, Shimizu M, Maruyama J, Mochizuki M.

[Meta-analysis of the efficacy and safety of Ginkgo biloba extract for the treatment of dementia.In: J Fr Ophtalmol (1988) 11(10):671-4 (Published in French)]

In: J Pharm Health Care Sci. 2015 Apr 10;1:14. doi: 10.1186/s40780-015-0014-7. eCollection 2015.

The benefit of Ginkgo biloba for the treatment of dementia remains controversial. The aim of this study was to evaluate the efficacy and safety of Ginkgo biloba in patients with dementia in whom administration effects were reported using meta-analysis.
METHODS: We searched MEDLINE, Embase, the Cochrane databases, and Ichushi for controlled trials of Ginkgo biloba for the treatment dementia. Clinical characteristics and outcomes were extracted. Meta-analysis results were expressed as standard mean differences (SMDs) in scores of the Syndrome Kurztest (SKT), Alzheimer’s Disease Assessment Scale Cognitive Subscale (ADAS-Cog) for cognition efficacy, or odds ratios (ORs) for dropouts and adverse drug reactions.
RESULTS: Thirteen studies using the extract EGb761 met our inclusion criteria, which were duration of 12 to 52 weeks and daily dose of more than 120 mg, and included a total of 2381 patients. Meta-analysis was performed by using 9 of 13 studies, 7 of which used the SKT and 2 ADAS-Cog (dose 120 mg, 26 weeks) scores as efficacy parameters. In meta-analysis of all patients, SMDs (95% confidence interval [CI]) in the change in SKT scores (7 studies) were in favor of Ginkgo biloba over placebo (SMD = -0.90 [-1.46, -0.34]), but 2 studies that used ADAS-Cog did not show a statistically significant difference from placebo for ADAS-Cog (-0.06 [-0.41, 0.30]). For Alzheimer’s disease (AD) and vascular dementia (VaD) subgroups, SMDs [95% CI] in SKT in the combined AD and VaD subgroup (-1.07 [-1.66, -0.47]) and AD subgroup (-1.36 [-2.27, -0.46]) were in favor of Ginkgo biloba over placebo. In terms of daily dose of Ginkgo biloba in the combined AD and VaD subgroup, SMD in SKT score in 240-mg daily dose groups was significantly greater than with placebo (-0.71 [-1.28, -0.14]). Dropout rates for any reason did not differ between two groups, but dropout rates due to side effects were significantly lower in Ginkgo biloba groups compared with placebo groups (OR = 1.72 [1.06, 2.80]).
CONCLUSIONS: Taking a 240-mg daily dose of Ginkgo biloba extract is effective and safe in the treatment of dementia.

For a more extensive list of Ginkgo Biloba abstracts go here.

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AMENDING THE HPDI FOUNDATIONAL SUPPLEMENTS PROGRAM

Dr. Hank Liers, PhDYears ago in the late 1980s, I found from experience that people’s health improved significantly when they used a foundational nutritional supplements program.

The reasons behind people’s need for foundational supplements: 1) Nutritionally deficient diets, 2) Excessive exposure to toxic chemicals, and 3) High levels of stress.

These reasons remain true today. But the three categories have become greater factors than previously. They seem to have gotten dramatically worse over time.

Due to these factors, and in light of new understandings based on scientific and clinical research, I have decided to amend the HPDI Foundational Supplements Program.

Consequently, in this article, I am introducing two new categories to the HPDI Foundational Program. These are: 1) Gut Health/Microbiome products and 2) Hydrogen products. The complete amended program is illustrated by the diagram below.

hpdi foundational supplements program

1.1. Diagram of the newly amended HPDI Foundational Supplements Program

HISTORY OF HPDI FOUNDATIONAL SUPPLEMENTS PROGRAM

The original HPDI foundational program was initially called the “Core Program” and consisted of a therapeutic multivitamin, a vitamin C/antioxidant  formula, and an essential fatty acid product. The essence of the foundation was based upon over 70 years of research during which the basic elements of nutrition were elucidated.

ADDING RNA TO THE CORE PROGRAM

When we became aware of the work of Dr. Benjamin S. Frank regarding ribonucleic acids (RNA) and the powerful affects RNA had on the body independently of the other nutritional components of the “Core Program”, it was clear that a new element was necessary and we developed and added High-RNA superfoods to our program.

At that time (circa 2005) we called it our HPDI Foundational Supplements Program. For more information on RNA see our blog articles entitled “DIETARY NUCLEIC ACIDS – DR. BENJAMIN S. FRANK, PART 1” and “DIETARY NUCLEIC ACIDS – DR. BENJAMIN S. FRANK, PART 2.”

hpdi foundational supplements program

Dr. Frank’s No-Aging Diet.

Amending the HPDI Foundational Supplements Program is a necessity based upon important new research and clinical studies. Even today many people do not understand the importance of RNA and its role in implementing the basic DNA structures of the body.

One reason that RNA has become so much more important than it was 40–50 years ago is that diets have basically become devoid of RNA. Muscle meats and processed foods have little RNA and the population is no longer eating sufficient high-RNA foods such as organ meats, fresh fish, and certain vegetables.

To learn more about the HPDI Foundational Supplements Program, click here to read our booklet “THE NEED FOR FOUNDATION SUPPLEMENTS.”

The Need for Foundational Supplements

What are foundational supplements? This booklet offers suggestions for improving intake of essential nutrients.

ADDING GUT HEALTH / MICROBIOME TO THE FOUNDATIONAL PROGRAM

More recently, the scientific community has discovered the importance of the human microbiome to our health. It is known there are about 10 times more bacterial cells living on and in the human body than the number of cells in our body. The amount of DNA carried by these bacterial cells is about 100 times the amount in our cells!! Many of these bacterial cells reside in the human gut. It is proven that these gut bacteria play a major role in keeping us healthy.

The issue of of how to create a healthy human microbiome is very complex. The problems start with how we grow our food. Beneficial, natural soil bacteria play an important role in helping to create healthy gut bacteria.

Yet, farming methods over the last 50-60 years have been oriented to the use of herbicides, pesticides, and synthetic fertilizers. These methods have basically destroyed much of the healthy bacteria in our soils. This means these bacteria cannot be passed on to the human gut.

In addition, the overuse of antibiotics in both animals and humans has further destroyed more of the healthy bacteria available to us.

According to Dr. Zachary Bush, healthy gut bacteria protect us from conditions of leaky gut. Without the healthy gut bacteria humans develop conditions of leaky gut, which leads to toxicity in the body from a variety of sources including pesticides (especially Roundup/glyphosate), antibiotics, medications, gluten, anti-inflammatories (such as ibuprofen), etc.

The story of how this all happens is clearly described by Dr. Bush in the video below (How to Fix Leaky Gut – CHTV 110).

Recent findings regarding the human microbiome clearly indicate the absolute necessity of finding ways to build a strong human microbiome. There are multiple ways a person can do this including healthy diets, avoidance of toxic chemicals and drugs, and with the use of certain supplements.

Dr. Bush has discovered a supplement using redox molecules found in lignite. These molecules were deposited in the lignite material millions of years ago by a broad range of healthy soil bacteria.

By extracting and activating these molecules and putting them into a liquid product called RESTORE™ he found that when people consumed this liquid they could regenerate a broad range of good bacteria in the gut (20,000–30,000 species). He also found they could simultaneously repair conditions of leaky gut. RESTORE™ also significantly helps with dehydration issues, which is another key factor in achieving good health.

Restore gut health hpdi foundational supplements program

Based on the importance of having a broad range of healthy gut bacteria and a robust microbiome—and RESTORE’s ability to cause this to happen—we have chosen to add RESTORE™ to  our amended HPDI Foundational program. HPDI is now carrying this product in 8 oz and 32 oz sizes. This product should be taken daily at an appropriate dose for you (up to 3 tablespoons daily).

ADDING HYDROGEN TO THE HPDI FOUNDATIONAL PROGRAM

Hydrogen is among the most fundamental elements in the universe and makes up a large percentage of all molecules. It is known that hydrogen and oxygen are key ingredients in the mitochondria used to make ATP, the principal energy molecule of the human body.

What was not known about hydrogen until recently was its powerful ability to safely trap free radicals and to stimulate the production of ATP.

We have written several blog articles recently that document the tremendous power of hydrogen to heal many conditions in the human body including:  “The Science Behind Megahydrate“, “Molecular Hydrogen at the Forefront of Health Research” and “Wonders of Molecular Hydrogen“.

Many studies have been conducted over the past 20 years showing the power of hydrogen in either the molecular hydrogen form or the hydride form.

hydrogen hpdi foundational supplements program

More recently, a number of hydrogen products have become available. These include molecular hydrogen tablets, silica hydride capsules, molecular hydrogen drinks, water ionizers producing molecular hydrogen, molecular hydrogen water purifiers, etc.

Based upon the research and product availability, we are amending the HPDI Foundation Supplement program to include silica hydride capsules (Megahydrate™) and molecular hydrogen tablets (Active H2) under the category of hydrogen.

Megahydrate™also plays a major role in hydrating the cells of the body. It is now feasible for people to take hydrogen products on a daily basis at reasonable cost. The benefits can be immense!

SUMMARY

six element hpdi foundational supplements program

Based on current research—and the availability of breakthrough products—we have amended the HPDI Foundation Supplement Program. The recommended program now includes:

multivitamin-pie-small 1. Therapeutic Multivitamin, including Hank & Brian’s Mighty Multi-Vite! or Multi Two
vitamin-c-pie-small2. Vitamin C/Antioxidant formula like PRO-C or Ultimate Protector™
fats-pie-small3. Essential Fatty Acids formula like Hank & Brian’s Essential Fats plus E
rna-pie-small4. High-RNA Superfoods from our Rejuvenate!™ product line
gut-pie-small5. Gut Health/Microbiome products, including RESTORE™
hydrogen-pie-small6. Hydrogen products, including Megahydrate™ and Active H2

 

We believe that to achieve optimal health these six types of supplements ideally need to be taken on a daily basis.

Over the next several months, we will update our websites to document more fully the amendments we have introduced to the HPDI Foundational Supplements Program.

ADDITIONAL RESOURCES

  1. An interview (see link below) by Dr. Pompa of Dr. Stephanie Seneff provides extremely important information regarding how GMOs are destroying the health of so many people, especially our children (https://www.youtube.com/watch?v=2PidYStbzHY).
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THE SCIENCE BEHIND MEGAHYDRATE

Dr Hank Liers PhD science behind MegahydrateI recently became aware of the health benefits of molecular hydrogen/hydrogen. We subsequently have written numerous blog articles on the subject (see resources section below), and elected to carry and endorse several products, including Active H2 and Megahydrate™. As a scientist, I am particularly impressed with the science behind Megahydrate, as well as the in-depth research studies carried out showing how it was developed and its health benefits.

For economic reasons, it is rare for a particular nutritional supplement to have in-depth scientific studies and clinical trials supporting its use. In this article, I will present some of the most relevant scientific information regarding Megahydrate.

 science behind Megahydrate

In a previous article “Water, Hydration, and Crystal Energy®” I discuss in-depth the science behind Dr. Patrick Flanagan’s use of nanometer-sized silica colloids to enable greater hydration of the body, enhanced absorption of nutritional ingredients into cells, and improved cellular detoxification.

In this article I will discuss the science and benefits of embedding hydrogen anions (hydride or H-) into these same nanometer-sized silica colloids that not only have all of the hydration benefits of Crystal Energy® but also exhibit potent antioxidant characteristics. The resulting substance is named by Dr. Flanagan “silica hydride” and his product that incorporates it is known as Megahydrate™ (originally Microhydrin™). The science behind the development of Megahydrate is provided below.

DEVELOPMENT OF AND SCIENCE BEHIND MEGAHYDRATE

The details of the materials development are provided in an article by Cory J. Stephenson and G. Patrick Flanagan titled “Synthesis of Novel Anionic Hydride Organosiloxane Presenting Biochemical Properties” published in the International Journal of Hydrogen Energy 28 (2003) 1243–1250.

Abstract
Synthesis of an anionic hydride from monomeric silsesquioxanes is described. The novel compound, dubbed “silica hydride” is the result of several newly synthesized compounds from an interstitially embedded hydride family. It is a hydride-based compound with H− ions interstitially embedded in a matrix of caged silica. This compound exhibits profoundly different characteristics than other known compounds in the hydride family. Unlike saline hydrides, the silica hydride demonstrates no overt or violent reaction with water or air. However, it is capable of generating aqueous reductive potential readings (ORP) of −750 mV for extended time periods. In vitro biological testing demonstrated no cytotoxicity induced by the compound while demonstrating efficacy as an antioxidant. In vivo studies of the compound have shown that it has a significant ability to reduce lactic acid build up in muscles by one-half after exercise. The synthesis of the silica hydride resulted in an approximately 16.8% w/w hydride content, as determined by density changes, proton NMR spectroscopy and ion beam analyses. Scanning and tunneling electron microscopy, Rutherford backscattering spectroscopy (RBS), forward recoil (FReS) ion beam analyses, in addition to Fourier transform infrared spectroscopy, reduction potential and 29Si CP-MAS solid state NMR were additionally used to characterize the compound.

Below relevant details from the article are provided to give insight into the science of the Megahydrate invention.

Introduction: The idea behind synthesis of the novel compound described in this article is based on the use of a monomer nanocomposite as a carrier in a bioencapsulated compound. The synthesis uses a silica and hydroxyl group terminated silsesquioxane monomer, trademarked Silica Microclusters®, that is interstitially imbedded with hydride anions as conceptually depicted in Fig. 1. The results from the characterization of this compound provide evidence to this claim, including DRIFTS FTIR and NMR data.

Figure 1 science behind Megahydrate

Figure 1. Conceptual diagram of Flanagan Microcluster structure. The tetrahedral coordination forms a three-dimensional framework by a series of Si–O–Si bonds, creating a silica cage.

With the immense potential for bioencapsulates and nanocomposite technologies, it would be very beneficial to create a hydride out of a compound that would involve the combinational reducing effects of a saline hydride compound and the beneficial attributes of the host compound, all without the reactivity of the saline hydrides. Synthesizing a biologically friendly hydride would have immense potential as an antioxidant and radical scavenger as discussed later in this paper.

It was discovered in the present work that if a hydride ionic plasma was placed under pressure, virtually any compound it came in contact with could then absorb its emitted ions. Since the 1920s, creating a hydride gas has been standard practice. One effective way is to add a current to a tungsten (W) lament in a hydrogen gas atmosphere. The lament separates hydrogen gas into a monovalent hydrogen gas while the photoelectric effect on the W lament donates electrons to the H gases forming a H− plasma. Langmuir, in 1927, while using the W lament hydride ion synthesis technique, discovered that moist air prevents hydride ions from recombining back into hydrogen gas.

Figure 2 science behind Megahydrate

Figure 2. The Concept of Silica Hydride. Conceptually the hydride embedded organosiliceous silsesquioxane, or silica hydride, is a monomeric silica-based cage with interstitially placed hydride anions. As a bioencapsulated compound, the silica acts as a colloidal carrier for the hydrogen anions in solution.

Details of Invention: The idea for this synthesis experiment was to then create a hydride plasma under a water vapor atmosphere and expose the plasma to an organosilicate compound, circumventing the problem of the hydrogen not having the catalysis or the electron availability to combine with the host substrate. Interestingly, Langmuir noted that the monoatomic ions produced by this process would become embedded in the glass walls of the tubing of his apparatus and that same tubing could later be induced to release the ions. The glass tubing used by Langmuir was a borosilicate glass, an amorphous siliceous compound. In the present study, an apparatus similar to what Langmuir used was constructed to create a plasma of H− ions. The H− atmosphere was applied to the pure Microcluster Silica powder under pressure and in the presence of a water vapor, creating a novel silsesquioxane bioencapsulated-hydride compound, dubbed: silica hydride.

Materials and methods: A 1.0 L sealed glass vessel was fabricated containing the items as depicted in Fig. 3. Two 5 cm × 0:6 cm diameter W rods were positioned transversely 2 mm apart in the top of the reaction vessel with two insulated leads connecting the W rods to a 20 A constant-current transformer (Lambda-EMI 102A-1KV, Neptune, NJ). Ten grams of MicroclusterJ silica was placed on the stage inside the vessel with 100 ml of distilled and deionized water added to the basin. A steady stream of hydrogen gas was bubbled through an aquarium stone in water and introduced to the reaction vessel, purging all of the air from the vessel and increasing pressure to 172 kPa at which time the vessel was sealed. A 500 V potential was applied to the W rods. At voltages ranging from 350 to 750 V, a constant arc could be maintained between the electrodes without melting. The potential was applied for 30 seconds at which time the current was shut off  and additional hydrogen was pumped into the vessel creating a captive plasma. The sample was allowed to sit in the plasma for 30 minutes at which time the silica sample was removed and weighed with an analytical balance.

Figure 3 science behind Megahydrate

Figure 3. Synthesis Apparatus. The representation of the apparatus used to synthesize the compound. A hydrogen gas generator (A) provides H2 gas that is sparged through a fllter stone in deionized, distilled water (B), where the hydrogen gas and water vapor are transported into a reaction vessel (C) with the substrate. Two tungsten electrodes (D) create a captive plasma H− gas via a constant current high-voltage power supply (E). Vessel evacuation, purge and sealing were performed using a mechanical valve (F). The resultant actions interstitially embed the hydride anions created by the plasma into the substrate.

Results: Determination of the mass of the anionic hydride organosiloxane sample showed an increase from 10.0 to 11.70 g upon exposure to the hydride plasma under pressure. The sample was allowed to sit at room temperature with desiccant in a glass vial for 3 weeks at open atmosphere at which time the proceeding analyses were performed.

An ion beam analysis was performed with the silica powder being pressed into a pellet (1.66 g/cm3) compared to a control standard. Rutherford backscattering spectroscopy (RBS) was analyzed with 2 MeV He beam, while 3 MeV He beam was used in a forward-recoil spectrometry (FReS) measurement. RBS suggests that the powder contains elements O and Si. Including H- content by FReS, the powder relative percentage makeup becomes H (78.1%), O (15.6%) and Si (6.2%). Trace amounts of boron (B) and W (<25 ppm) were also observed. Original values from samples of non-reacted Microcluster silica comparatively illustrate an elemental makeup of H (22.4%), O (55.6%) and Si (21.9%). A 1H-NMR characterization was performed and showed a 16.8% hydride content.

Scanning electron microscopy analysis with a 40 KeV-JEOL 840II microscope illustrated small, ∼ 2 microns, spheres consisting of numerous smaller spheres. A 300 KeV-CM30 transmission electron microscope allowed the resolution to image very small, spherical compounds that were measured to be about 50 Angstroms. An energy dispersive X-ray spectrometer qualified an elemental analysis of the compound to contain Si and O.

The ORP and pH were recorded for 250 ml distilled and deionized water in a Pyrex beaker. 10.0 g/ml of the siliceous hydride was added to the beaker and allowed to stir for 15 min at which time addition ORP and pH readings were taken. The initial ORP and pH of the water averaged 341.33±2.5 mV and pH 7.12±0.06, respectively. The readings after 15 min were −436.21 ± 2.1 mV for the ORP and 9.13 ± 0.09 for the pH measurements.

The hydrogen pressure unbiased reducing potential, rH, was calculated. The use of rH gives a hydrogen proton-unbiased look at the absolute reducing potential of a compound, eliminating the effects of pH in the ORP measurement. The measured rH for the compound was 11.02 ± 0.04 indicating a highly reduced environment.

Discussion: The synthesis process appears to cluster the organosilicate subunits into hydrogen-bonded aggregates that further group into approximately 2 micron clusters as shown in Fig. 4A. Dissolution in water decreases the cluster size from 2 microns to the smaller subunits of about 500 nm, then into individual cages of about 50 A (Fig. 4B).

 Figure 4 science behind Megahydrate

 

This new organosilicate silsesquioxane compound, commonly named silica hydride, has been the subject of numerous tests involving reduction potential (ORP) and pH as well as being analyzed as an effective antioxidant. Adding a few mg to water will drop an ORP reading by −750 mV. A recent publication of a clinical study has illustrated the capability of this compound to significantly reduce lactic acid after exercise by 50%. Viability and cytotoxicity probes show that the silica hydride does not cause any decrease in intracellular esterase activity or otherwise induce a toxic cytoplasmic environment. There are a plethora of uses of a hydride-based compound such as silica hydride since it does not impose a direct negative effect to cellular viability and cytoplasmic health. Particular uses include nutritional supplementation as an antioxidant. The incredible reduction potential of silica hydride adds to the possible uses of this type of compound.

The compound does not react violently or visibly with H2O. However, it will reduce the ORP reading to −750 mV for a period of at least several weeks. Most antioxidant compounds are relatively large chemical species. Examples of this are vitamins A, K, C, ubiquinone and n-acetyl-l-cysteine. It is hypothesized that steric hindrances may affect the efficacy of antioxidants. The small size and reducing capacity of silica hydride, the silsesquioxane hydride compound, may lead to future development as an antioxidant.

Conclusion: The novel siliceous compound acts as a colloidal carrier for the very small hydride anions that are released in an aqueous solution. This nanosized colloidal bioencapsulated compound could be an incredibly effective radical scavenger and aid in the reduction of oxidative stress due to its minimal size and high reduction potential.

This novel compound presented in this paper has demonstrated promising in vitro and in vivo biochemical significance with uses including reducing agents, antioxidants and nutritional supplementation. The synthesis is simple and effcient with consistent results of about 17% w/w hydride content with respect to the starting compound. Biologically friendly compounds that incorporate health-beneficial minerals, such as silica, with the scavenging and reducing capabilities of a hydride provide for numerous possibilities of uses.

THE PATENT AND SCIENCE BEHIND MEGAHYDRATE

After inventing Megahydrate (formerly Microhydrin), Dr. Flanagan (and his associates) conducted studies on its efficacy for a range of benefits for human health. The material was then patented in 2003. Key elements of the patent are provided below and a link to the entire content is provided if you wish to read further details.

Methods of using silica hydride mineral
US 20030190374 A1

ABSTRACT

The exact health benefits of silica hydride minerals, traditionally found in glacial streams, have long been the subject of speculation. Geochemical analysis indicates that such colloidal silica hydrides in water possess a silica-water interface that provides a hydrated surface and adsorbs other elements or compounds such as potassium, iron, magnesium, lithium, calcium, and hydrogen. Dietary supplements with similar properties have been formulated. When the silica-water interface of such compounds is saturated with reduced hydrogen, the compounds take on an overall negative charge and act as a reducing agent or antioxidant when in solution. When consumed, hydride ions introduced into the body by the silica hydride supplement donate electrons to body fluids. With proper dosages, the benefits of consuming silica hydride include reduction of lactic acid build-up, increasing cellular hydration, reduction of free radical damage, enhancement of mitochondrial bioenergetic capacity, increasing antioxidant activity, and enhancing the properties of drinking water.

DESCRIPTION

TECHNICAL FIELD OF THE INVENTION
This invention relates to methods of using silica hydride minerals. More particularly, this invention relates to methods of using silica hydride minerals that have beneficial effects on lactic acid buildup during exercise, cellular hydration, free radical damage, mitochondrial bioenergetic capacity, antioxidant activity, and the suitability of water for conversion into optimal cellular body fluids.

BACKGROUND OF THE INVENTION
Amorphous silicate minerals, many of which are in the nanoparticle size range, were once common in natural water sources and abundant in glacial stream waters. Not only do the silica mineral particles bond water and other elements for transport; they also can be adsorbed with reduced hydrogen, which releases electrons, providing antioxidant or reducing potential to surrounding fluids.

In one region of West Pakistan the people are known to enjoy excellent health and amazing longevity. A team of cardiologists found the heart health of the people to be exceptionally good and evidence of the people’s delayed aging. The cardiologists attributed the good health and longevity in significant part to the abundance of colloidal silicate minerals in the glacial streams the people used for irrigation of food crops and drinking water.

Geochemical analysis indicates that colloidal silicate minerals display a variety of properties, including the formation of structured water around the silica-water interface, which provides a hydrated surface that adsorbs elements or compounds such as potassium, iron, magnesium, lithium, calcium, and hydrogen. FIG. 5 illustrates an example of the silica-water interface and the concentric structured water arrangement about the interface with the adsorption of elements within the layers.

Figure 5 science behind Megahydrate

Figure 5. An enlarged view of a hypothetical silica hydride particle showing the silica-water interface and other adsorbed elements.

 

From silicate analogs, it is possible to formulate dietary supplements that are similar to the colloidal silicate minerals found in glacial waters and retain the geo-physical properties inherent to these minerals. An example of such synthesized silicate analogs is a silica hydride formula sold under the trademark Microhydrin®. Substances possessing the characteristics and functions described in this application, such as Microhydrin®, have assumed many names.

For example, in addition to being called silica hydrides, such substances are known as amorphous silicate minerals, silicate particles, silicates, colloidal silicate minerals, silicate analogs, synthesized silicate analogs, functional silicate nanocolloids, dielectric interstitial hydrides, dietary silicate supplements, or dietary silicate antioxidants. Considering the many labels afforded this class of substances, the characteristics and functions of supplements must necessarily determine whether a particular supplement falls within the class.

Referring again to FIG. 5, the particle’s silica-water interface can be saturated with reduced hydrogen, or hydride (H-) ions, and takes on an overall negative charge. In such cases, the particle then acts as a reducing agent or antioxidant when in solution (standard reduction-oxidation potential, −550 mV). It is capable of providing literally trillions of hydride ions able to donate electrons into body fluids.

Electrons, which Albert Szent-Gyorgyi called the “fuel of life,” are abundantly available in inorganically grown raw vegetables, fruits, and grains, but are deficient in our modem diet of over-cooked, acidic, or highly oxidized foods, beverages, and drinking water. In silica hydride minerals, the structured water around the silica-water interface stabilizes electron transfer. Such specific silicate interactions could play a substantial role in many biological processes by enhancing salvation properties and ion and water transport and by providing free radical antioxidant protection.

Such electron deficiencies resulting from inadequate diet have a derogatory impact on specific biological processes such as lactic acid build-up, cellular hydration, damage from free radicals, mitochondrial bioenergetic capacity, antioxidant activity, and suitability of drinking water for conversion into optional cellular body fluids. Therefore, a need exists for a method of counter balancing these electron deficiencies and, as a result, enhancing each of these biological phenomena.

SUMMARY OF THE INVENTION
The present invention identifies certain beneficial health effects of silica hydride minerals and the effective doses necessary to achieve desired results. With proper dosages, the benefits of using silica hydride minerals as a dietary supplement include: reduction of lactic acid buildup during and after exercise, increasing cellular hydration, reduction of free radical damage, enhancement of mitochondrial bioenergetic capacity, increasing antioxidant activity, and enhancing the suitability of water for conversion into optimal cellular body fluids.

PATENT CLAIMS

1. A method of reducing lactic acid buildup during and after exercise comprising ingesting an effective dose of silica hydride mineral.
2. A method of increasing cellular hydration comprising ingesting an effective dose of silica hydride mineral.
3. A method of reducing free radical damage comprising ingesting an effective dose of silica hydride mineral.
4. A method of enhancing mitochondrial bioenergetic capacity comprising ingesting an effective dose of silica hydride mineral.
5. A method of increasing antioxidant activity comprising ingesting an effective dose of silica hydride mineral.
6. A method of making water more suitable for conversion into optimal extracellular and intracellular body fluids comprising ingesting water mixed with an effective dose of silica hydride mineral.
7. A method of improving the characteristics of body fluids, such as saliva pH, saliva rH2, blood resistivity, urine resistivity, urine pH, urine rH2, and saliva resistivity comprising ingesting an effective dose of silica hydride mineral.

SOME BENEFITS OF MEGAHYDRATE INDICATED BY SCIENTIFIC STUDIES

  • Contains Hydrating Silica Microclusters®
  • Extremely Powerful Antioxidant
  • Recycles other Key Antioxidants in the Body
  • Extremely Safe and Non-Toxic
  • Easily Accesses All Cells in the body
  • Increases Cellular ATP Production by up to a factor of 4 times
  • Readily Converts NAD+ to NADH
  • Reduces Pain & Inflammation
  • Exhibits Powerful Anti-Aging Properties
  • Protects and Repairs DNA
  • Neutralizes Harmful Toxins like Fluoride, Chlorine, etc.
  • Protects Against and Repairs Radiation Damage
  • Increases Absorption of other Supplements
  • Lowers surface tension of water you drink leading to improved detoxification
  • Removes Heavy Metals from the Body
  • Balances pH or Alkalizes the body
  • Increases Zeta Potential of Human Cells
  • Increases Cellular Hydration
  • Very Stable – Works Over Extensive Time Periods
  • Reduces Lactic Acid Buildup During Intense Workouts
  • Protects Telomeres by allowing cells to exceed the Hayflick limit by 4-5 times

ADDITIONAL RESOURCES

Molecular Hydrogen Foundation (MHF)

Hydrogen for Optimal Health
by Fred Liers, PhD (from the HPDI blog)

Wonders of Molecular Hydrogen
by Fred Liers, PhD (from the HPDI blog)

Molecular Hydrogen (H2) at the Forefront of Health Research
by Hank Liers, PhD (from the HPDI blog)

ACTIVE H2 (tablet)

H2BEV (bottle)

MegaHydrate™ (capsule)

Contact Us:

You can reach HPDI by calling 1-800-228-4265, email support(at)IntegratedHealth.com, or visit the retail website: www.IntegratedHealth.com

Health care professionals and retailers can apply for wholesale account, which includes access to the HPDI reseller website: www.HealthProductsDistributors.com

0

ULTIMATE PROTECTOR INGREDIENTS – CRANBERRY

Hank Liers cranberries cranberry ultimate protector Nrf2Ultimate Protector™ contains freeze dried cranberry, as well as components from 29 different fruits, vegetables, and herbs. Each of these ingredients contain substances that may be considered to be polyphenols, antioxidants, and Nrf2 activators. In this article I explore the ingredient strawberries, which is a component of VitaBerry Plus® from Futureceuticals.

VITABERRY PLUS®

VitaBerry® (N1023) is the trade name for a line of high ORAC blends of fruit powders and fruit extracts, exclusively available through FutureCeuticals.

VitaBerry® is a proprietary formula that combines wild bilberry and wild blueberry, cranberry, raspberry, strawberry, prune, cherry, and grape whole powders and extracts into lines of custom blends. High in fruit polyphenols, anthocyanins, proanthocyanins, ellagic acid, chlorogenic acid, resveratrol, and quinic acid, VitaBerry offers 6,000 ORAC units in a single gram.

VitaBerry® Plus (N81.3) combines the standard blend of VitaBerry® with resveratrol and quercetin to deliver a minimum of 12,000 ORAC units per gram.

Cranberry

Cranberries

HEALTH BENEFITS OF CRANBERRIES

Cranberries (Vaccinium macrocarpon) are native to the boggy regions of temperate and subalpine North America and Europe. Although Native Americans used them extensively, they were first cultivated in the U.S. in the early 19th century. Cranberries grow on viney plants belonging to the heath family Ericaceae that also includes blueberries, bilberries, huckleberries, and bearberries (Arctostaphylos uva ursi). Cranberries contain tannins, fiber, anthocyanins (and other flavonoids), and Vitamin C. Their tannins prevent bacteria from attaching to cells. Consequently, cranberries have been used against infections, including urinary tract infections. In addition, cranberries may be helpful in protecting against heart disease and stroke.

Cranberries are an especially good source of antioxidant polyphenols. In animal studies, the polyphenols in cranberries have been found to decrease levels of total cholesterol and so-called “bad” cholesterol. Cranberries may also inhibit the growth of tumors in human breast tissue and lower the risk of both stomach ulcers and gum disease. 

Here is a list of the antioxidant and anti-inflammatory phytonutrients in found in cranberries.

Type of Phytonutrient             Specific Molecules
Phenolic Acids                             hydroxybenzoic acids including vanillic acids;
—Phenolic Acids (cont.)             hydroxycinnamic acids inculding caffeic,
—Phenolic Acids (cont.)             coumaric, cinnamic, and ferulic acid
Proanthocyanidins                     epicatechins
Anthocyanins                              cyanidins, malvidins, and peonidins
Flavonoids                                   quercetin, myricetin, kaempferol
Triterpenoids                              ursolic acid

Other Cranberry Information

  • Cranberries hold significantly high amounts of phenolic flavonoid phytochemicals called oligomeric proanthocyanidins (OPC’s). Scientific studies have shown that consumption of the berries have potential health benefits against cancer, aging and neurological diseases, inflammation, diabetes, and bacterial infections.
  • Antioxidant compounds in cranberries including OPC’s, anthocyanidin flavonoids, cyanidin, peonidin and quercetin may prevent cardiovascular disease by counteracting against cholesterol plaque formation in the heart and blood vessels. Further, these compounds help the human body lower LDL cholesterol levels and increase HDL-good cholesterol levels in the blood.
  • Scientific studies show that cranberry juice consumption offers protection against gram-negative bacterial infections such as E.coli in the urinary system by inhibiting bacterial-attachment to the bladder and urethra.
  • In is known that cranberries turns urine acidic. This, together with the inhibition of bacterial adhesion helps prevent the formation of alkaline (calcium ammonium phosphate) stones in the urinary tract by working against proteus bacterial-infections.
  • In addition, the berries prevent plaque formation on the tooth enamel by interfering with the ability of the gram-negative bacterium, Streptococcus mutans, to stick to the surface. In this way cranberries helps prevent the development of cavities.
  • The berries are also good source of many vitamins like vitamin C, vitamin A, ß-carotene, lutein, zea-xanthin, and folate and minerals like potassium, and manganese.
  • Oxygen Radical Absorbance Capacity (ORAC) demonstrates cranberry at an ORAC score of 9584 µmol TE units per 100 g, one of the highest in the category of edible berries.

For more information on cranberries visit the sites given below:
https://www.healthambition.com/health-benefits-of-cranberry-juice/
or
http://www.whfoods.com/genpage.php?tname=foodspice&dbid=145

Scientific Studies on the Antioxidant Effects of Cranberry

Below, I provide relevant scientific studies on the antioxidant effects and potential health benefits of cranberries.

Prevention of oxidative stress, inflammation and mitochondrial dysfunction in the intestine by different cranberry phenolic fractions.

Abstract

Cranberry fruit has been reported to have high antioxidant effectiveness that is potentially linked to its richness in diversified polyphenolic content. The aim of the present study was to determine the role of cranberry polyphenolic fractions in oxidative stress (OxS), inflammation and mitochondrial functions using intestinal Caco-2/15 cells. The combination of HPLC and UltraPerformance LC®-tandem quadrupole (UPLC-TQD) techniques allowed us to characterize the profile of low, medium and high molecular mass polyphenolic compounds in cranberry extracts. The medium molecular mass fraction was enriched with flavonoids and procyanidin dimers whereas procyanidin oligomers (DP > 4) were the dominant class of polyphenols in the high molecular mass fraction. Pre-incubation of Caco-2/15 cells with these cranberry extracts prevented iron/ascorbate-mediated lipid peroxidation and counteracted lipopolysaccharide-mediated inflammation as evidenced by the decrease in pro-inflammatory cytokines (TNF-α and interleukin-6), cyclo-oxygenase-2 and prostaglandin E2. Cranberry polyphenols (CP) fractions limited both nuclear factor κB activation and Nrf2 down-regulation. Consistently, cranberry procyanidins alleviated OxS-dependent mitochondrial dysfunctions as shown by the rise in ATP production and the up-regulation of Bcl-2, as well as the decline of protein expression of cytochrome c and apoptotic-inducing factor. These mitochondrial effects were associated with a significant stimulation of peroxisome-proliferator-activated receptor γ co-activator-1-α, a central inducing factor of mitochondrial biogenesis and transcriptional co-activator of numerous downstream mediators. Finally, cranberry procyanidins forestalled the effect of iron/ascorbate on the protein expression of mitochondrial transcription factors (mtTFA, mtTFB1, mtTFB2). Our findings provide evidence for the capacity of CP to reduce intestinal OxS and inflammation while improving mitochondrial dysfunction.

 Chemical characterization and chemo-protective activity of cranberry phenolic powders in a model cell culture. Response of the antioxidant defenses and regulation of signaling pathways

Abstract

Oxidative stress and reactive oxygen species (ROS)-mediated cell damage are implicated in various chronic pathologies. Emerging studies show that polyphenols may act by increasing endogenous antioxidant defense potential. Cranberry has one of the highest polyphenol content among commonly consumed fruits. In this study, the hepato-protective activity of a cranberry juice (CJ) and cranberry extract (CE) powders against oxidative stress was screened using HepG2 cells, looking at ROS production, intracellular non-enzymatic and enzymatic antioxidant defenses by reduced glutathione concentration (GSH), glutathione peroxidase (GPx) and glutathione reductase (GR) activity and lipid peroxidation biomarker malondialdehyde (MDA). Involvement of major protein kinase signaling pathways was also evaluated. Both powders in basal conditions did not affect cell viability but decreased ROS production and increased GPx activity, conditions that may place the cells in favorable conditions against oxidative stress. Powder pre-treatment of HepG2 cells for 20 h significantly reduced cell damage induced by 400 μM tert-butylhydroperoxide (t-BOOH) for 2 h. Both powders (5–50 μg/ml) reduced t-BOOH-induced increase of MDA by 20% (CJ) and 25% (CE), and significantly reduced over-activated GPx and GR. CE, with a significantly higher amount of polyphenols than CJ, prevented a reduction in GSH and significantly reduced ROS production. CJ reversed the t-BOOH-induced increase in phospho-c-Jun N-terminal kinase. This study demonstrates that cranberry polyphenols may help protect liver cells against oxidative insult by modulating GSH concentration, ROS and MDA generation, antioxidant enzyme activity and cell signaling pathways.

Cranberry extract suppresses interleukin-8 secretion from stomach cells stimulated by Helicobacter pylori in every clinically separated strain but inhibits growth in part of the strains

From: http://www.sciencedirect.com/science/article/pii/S1756464613000364

Abstract

It is known that cranberry inhibits the growth of Helicobacter pylori (HP). In human stomach, HP basically induces chronic inflammation by stimulating stomach cells to secrete interleukin (IL)-8 and other inflammatory cytokines, and causes stomach cancer, etc. The aim of this study was to investigate the inhibiting effects of cranberry on HP growth and IL-8 secretion from stomach cells induced by HP, using clinically separated HP strains. HP growth in liquid culture and on-plate culture was evaluated by titration after 2-day incubation and by agar dilution technique, respectively. For IL-8 experiments, MKN-45, a stomach cancer cell line, was incubated with HP for 24 h and IL-8 in the medium was assayed by ELISA. Cranberry suppressed growth of the bacteria only in six of the 27 strains. Meanwhile, it suppressed IL-8 secretion in all the strains. The results may suggest a possible role of cranberry in prevention of stomach cancer by reducing gastric inflammation.

Effects of cranberry powder on biomarkers of oxidative stress and glucose control in db/db mice

From: http://www.ncbi.nlm.nih.gov/pubmed/24353827

Abstract

Increased oxidative stress in obese diabetes may have causal effects on diabetic complications, including dyslipidemia. Lipopolysccharides (LPS) along with an atherogenic diet have been found to increase oxidative stress and insulin resistance. Cranberry has been recognized as having beneficial effects on diseases related to oxidative stress. Therefore, we employed obese diabetic animals treated with an atherogenic diet and LPS, with the aim of examining the effects of cranberry powder (CP) on diabetic related metabolic conditions, including lipid profiles, serum insulin and glucose, and biomarkers of oxidative stress. Forty C57BL/KsJ-db/db mice were divided into the following five groups: normal diet + saline, atherogenic diet + saline, atherogenic diet + LPS, atherogenic diet + 5% CP + LPS, and atherogenic diet + 10% CP + LPS. Consumption of an atherogenic diet resulted in elevation of serum total cholesterol and atherogenic index (AI) and reduction of high density lipoprotein (HDL)-cholesterol. However, with 10% CP, the increase in mean HDL-cholesterol level was close to that of the group with a normal diet, whereas AI was maintained at a higher level than that of the group with a normal diet. LPS induced elevated serum insulin level was lowered by greater than 60% with CP (P < 0.05), and mean serum glucose level was reduced by approximately 19% with 5% CP (P > 0.05). Mean activity of liver cytosolic glutathione peroxidase was significantly increased by LPS injection, however it was reduced back to the value without LPS when the diet was fortified with 10% CP (P < 0.05). In groups with CP, a reduction in mean levels of serum protein carbonyl tended to occur in a dose dependent manner. Particularly with 10% CP, a reduction of approximately 89% was observed (P > 0.05). Overall results suggest that fortification of the atherogenic diet with CP may have potential health benefits for obese diabetes with high oxidative stress, by modulation of physical conditions, including some biomarkers of oxidative stress.

Ultimate Protector cranberry cranberries

SUMMARY

Cranberries are an important fruit full of polyphenols, anthocyanins, antioxidants, and Nrf2 activators that help to make Ultimate Protector such an outstanding nutritional supplement.

ADDITIONAL RESOURCES

 

Contact Us:

You can reach HPDI by calling 1-800-228-4265, email support(at)IntegratedHealth.com, or visit the retail website: www.IntegratedHealth.com

Health care professionals and retailers can apply for wholesale account, which includes access to the HPDI reseller website: www.HealthProductsDistributors.com

2

WATER, HYDRATION, AND CRYSTAL ENERGY®

hydration water crystal energy

Dr Hank Liers PhD hydration crystal energyIn this article, my goal is to provide a more in-depth understanding of the importance of water and hydration to human health. In my recent research on these subjects, it became clear that our common understanding of water is inadequate to provide us with the knowledge of how we may significantly improve our health using water in ways that can vastly improve the hydration and health of our tissues and cells.

To accomplish my goal, it is important to gain a better understanding of the fourth state of water and how the water in our bodies are primarily in this state. A relatively short video by Dr. Gerald Pollack provides significant illumination on this subject. His book The Fourth Phase of Water: Beyond Solid, Liquid, and Vapor is recommended for those wishing to study in greater depth on this topic. 

The fact is that most of the water in the human body exists in this fourth or “structured” state. Furthermore, Dr. Pollack points out that water surrounding colloidal particles such as silica colloids is also in this structured state. Dr. Patrick Flanagan has applied this understanding along with a method of producing nanometer sized silica colloids to enable greater hydration of the body, enhanced absorption of nutritional ingredients into cells, and improved cellular detoxification. Dr. Flanagan has incorporated these elements into his Crystal Energy® product.

To provide quantification of the benefits of Crystal Energy, I have provided a somewhat simplified version of an article titled: Quantitative Analysis of Membrane Diffusion Kinetics and Surface Tension Differentiation by a Colloidal Silicate Minerals by Cory J. Stephanson, PhD and G. Patrick Flanagan, MD, PhD. For those wishing a more complete understanding of hydration and Crystal Energy, please read their full article.

BACKGROUND

Water (H2O) has a profound effect on our lives. The surface of the earth is 75% covered by water. The human body is about 67% water by weight and because of its low molecular weight 99% of the molecules in the human body are H2O. According to chemistry books there are three states of water solid (ice), liquid, and gas (vapor).

hydration water states

However, deeper studies of water in more recent years have revealed a fourth state of water called by various names such as exclusion zone (EZ) water, structured water, fourth phase of water, and crystalline water. One of the primary researchers of water is Dr. Gerald Pollack from the University of Washington. Dr. Pollack’s TED talk included below (https://www.youtube.com/watch?v=i-T7tCMUDXU) gives us a broad view of the properties of the fourth state of water. It is highly recommended that you view this video as the facts revealed are not commonly known, but are profoundly important in our lives!

HYDRATION

The issues of hydration of the human body are highly important. With regards to physiological and biological implications, significance and impact, no nutritional substance is equal to or greater than the importance of water. Water maintains multifaceted uses biologically as a solvent, catalyst, and carrier for other reactions and compounds. The interaction of water and biological fluids is a profound topic that bears significant nutritional consideration. Changes in physical rheology of water can have a profound effect on the amount of materials that water can carry to and from the interior of cells.

With aging, the body’s mechanisms of water balance are disturbed, increasing the risk of dehydration (and loss of hydration) among the elderly. Dehydration is indeed the most common fluid disorder among older persons, and it can have considerable clinical impact. It is estimated that between the ages of 30 and 70 years old the body loses about 15% of its capacity to retain water.

Reasons for the loss of capacity to retain water include: 1) The elderly often experience reduced thirst sensation which leads to decreased fluid consumption, especially following water deprivation, 2) As a consequence of aging, renal water conservation is impaired. Aged kidneys are less able to concentrate urine, and thereby to retain water during water deprivation, and 3) Aging is associated with limitations such as reduced swallowing capacity, reduced mobility, or comprehension and communication disorders, which can lead to insufficient fluid intake, 4) Disease-related factors, such as fever, diabetes, or incontinence can increase water losses, and 5) Dehydration may also be caused by environmental factors (warm temperature, inadequate knowledge or the lack of time of care workers in institutions contributing to inadequate fluid intake) or iatrogenic factors (medications including laxatives, diuretics or angiotensinconverting enzyme inhibitors, and medical procedures such as those requiring fasting).

IMPORTANCE OF CELLULAR HYDRATION

The great majority of people do not recognize the absolutely crucial value of drinking the right kind of water for purposes of hydration. When doctors say, “Drink plenty of water or you will become dehydrated,” they are talking about the water around your cells, the intercellular water. However, here we’re talking about cellular hydration, the water inside the cells themselves.

Research in the field of cellular hydration has shown that when the cell swells up, it triggers an anabolic mechanism in the body, which is a healing mechanism. It is accompanied by positive nitrogen balance, protein synthesis, and growth hormone release, equivalent to useful levels even in older people. Cellular hydration also results in a reduction of cell acidity, reduced autoimmune response, increased fat burning, DNA repair, and increased resistance to viruses.

Now when the cells become dehydrated, it triggers a catabolic state accompanied by muscle wasting, cell hypoxia (oxygen starvation), DNA damage, and accelerated aging. As a result the cell becomes more sensitive to free radicals and more susceptible to viruses and autoimmune diseases. Virtually all symptoms of aging are the result of cellular dehydration accompanied by free radical damage. As such, proper hydration is essential for improved health.

SURFACE TENSION, WETTING, AND HYDRATION

Surface tension is an important indicator of the rheology or flow characteristics of water through a living system and across cell membranes. When a drop of liquid is placed on a solid or another secondary liquid, the first liquid either spreads to form a thin, more or less uniform film or remains as a discrete drop. The degree of interaction between the drop and the film is known as wetting. The former behavior is generally described as complete wetting, and the latter as incomplete or partial wetting of the surface.

The external measure of the degree of wetting is the contact angle, i.e., the angle formed between planes tangent to the surfaces of the solid and the liquid at the wetted perimeter. A zero contact angle is the condition for complete wetting of a solid by a liquid (e.g., water on clean glass). This concept is exceptionally important in the discussion of the nutritional aspects of a liquid. To fully discuss the phenomena and details of liquid interaction, it is important to understand the concepts of three terms: surface tension, wetting tension, and wetting angle.

Surface tension is the force that exists between a liquid and the atmosphere it is in. For example, in atmospheric air, a drop of water will bead up on some solid surfaces. It is the surface tension existing between the water and the air that allows this to occur. The drop of water can spread out on another solid surface if the new surface has molecular forces (surface energy) high enough to overcome the water/air surface tension and draw the water flat onto it.

Wetting tension is the maximum liquid surface tension that will spread, rather than bead up, on the film surface. It is a measurable property that estimates a film’s surface energy. Wetting tension is determined by applying different test solutions of increasing surface tensions until one is found that just spreads (wets) the film surface. Units are dynes/cm.

Contact or wetting angle (the angle θ shown in the diagram below) is a measurement of the behavior of pure water in contact with the film surface. The surface energy of the film controls whether the droplet tends to stand up or flatten out. This is quantified by measuring the contact angle of the droplet with the surface. A higher energy film will cause the droplet to be flatter and closer to the surface, which results in a smaller contact angle value.

 

hydration surface tension water

Ordinary water has a high surface tension, as well as a high wetting angle, which means it has a difficult time wetting the cells within the body. In the body our cell membranes contain a significant amount of phospholipids (fats), which have low surface tension of about 45 dynes/cm. Cells require a surface tension of about the same range for water to wet the cells, thus passing through the cell wall carrying nutrients etc. This concept is the same relationship as the idea that oil and water do not mix. Normal tap water has a surface tension of 73 dynes/cm which is able to suspend the cells in the body, but is not in intimate contact with the surface of the cell, passes through the body, and is not fully utilized by the cells. Higher surface tension water can actually dehydrate cells in which it comes into contact.

The lower the surface tension, the lower the wetting angle and the “wetter” the water becomes. With a lower surface tension and a low wetting angle, cells become fully hydrated and the water is fully and most effectively utilized by the body. By this means, cellular hydration is achieved.

BIOLOGICAL EFFECTS OF WATER

Of direct biological interest, if for any reason nutrients are unable to influx into cells or efflux and remove the toxins from cells, the cells die due to accumulation of their own metabolic waste products.

In order for toxins to leave the cells and nutrients to enter the cells, the cells must be in intimate contact with water. Thus, a low surface tension environment is optimal for cellular health. In fact, it has been demonstrated that an increase of over 64 times nutrient capacity was observed by doubling the speed of fluid flow. Lowering surface tension and wetting angle is directly related to the speed of the fluid across cell membranes.

Hence, while water is one of the most important things we can put into our body, it is only the right kind of water that produces health and longevity. An individual could drink significant volumes of water at 73 dynes/cm, but without the micronutrients in your body to make the conversion to 45 dynes/cm, the body will be dehydrated at a cellular level.

Dehydrated cells metabolize in a catabolic state, which means the body starts utilizing its own tissue for energy production, resulting in degeneration of cellular health and immune response. Over time this process may result in auto immune diseases, such as lupus, MS, Chronic Fatigue, Rheumatoid Arthritis, allergies, and many more degenerative processes.

With this in mind, it is of utmost importance to make sure that the dietary intake of water is in its most useful form, i.e., the form that produces the greatest hydration in the body. There are many compounds and supplements that claim to catalytically increased nutrient absorption, however, most are unable to produce any empirical or other evidence to support those claims.

CRYSTAL ENERGY®

Crystal Energy hydrationRecent assays evaluating the functionality and efficacy of the nutritional supplement, Crystal Energy®, demonstrate the innate ability of the compound to reduce surface tension and wetting angle, while increasing nutrient absorption through increased fluid speed and diffusion rates. All the while increasing the conductivity and dissolved solids within the solution. Crystal Energy®, is the retail name for Flanagan Microcluster® colloids, that were developed and perfected by Dr. G. Patrick Flanagan.

Dr. Flanagan discovered that anomalous properties that sustain increased longevity and lifespan are the result of a special type of colloidal mineral found in some types of water. This is true of five main areas in the world, including Hunzaland in Pakistan, where larger numbers of people are often known to live past 100 years old while maintaining excellent health. Locals from these areas attribute their longevity to the water they drink. It was the study of these special minerals and ions that led to the development of Crystal Energy® concentrate.

Microcluster minerals, which are found in Crystal Energy, alter the structure of drinking water and reduce the surface tension. These attributes are the keys to the secrets of the Hunza water.

Microcluster minerals are unique in that they have a very high electrical charge (Zeta potential) and are small enough to be easily utilized in the body. Normally the charges on ordinary colloidal minerals have little or no effect on the structure of water. Colloids that are found in dead sea beds and mineral clays have low zeta potential and are too large to be used by a living system.

Zeta potential represents a basic and fundamental Law of Nature. It plays a vital role in all forms of plant and animal life. It is the force that maintains the discreteness of the billions of circulating cells that nourish the organism.

Microcluster minerals consist of elements and combinations of elements which are by definition in the smallest possible size range while still remaining molecules. When Flanagan Microcluster® silica colloids are diluted for drinking, they have such powerful surface energies that they have a profound and significant effect on the water, including decreased surface tension, as measured in dynes per centimeter.

Hunza water has a surface tension value of 58 dynes/cm. Crystal Energy treated water has an even lower surface tension than Hunza water and a greater Zeta potential, providing a more advantageous environment in the organism. Assimilation of nutrients and vitamins from our foods is largely dependant on our body’s ability to wet and process nutrients in the digestive system.

The ability to wet foods depends on the Zeta potential and surface tension of our digestive fluids. Through this mechanism, Crystal Energy demonstrates a significant impact on how nutrients are absorbed into the living system.

To quantify the efficacy and mechanism of Crystal Energy, a series of analytical tests were performed: Diffusion kinetics to determine the fluid speed and nutrient absorption characteristics were measured through the spectrophotometric monitoring of visible light absorbance of a food-grade dye and select vitamins in water, osmotically diffusing across a semi-permeable dialysis membrane. Additional assays were performed following the change in surface tension, conductivity and total dissolved solids with the incremental addition of Crystal Energy to various waters.

Surface Tension Analysis: The surface tension levels of ten different commercially available waters were analyzed before and after treatment with Crystal Energy. Surface tension was monitored by a Du Nouys Ring Model 21 Surface Tensiomat and measured in dynes per centimeter. Total Dissolved Solids (TDS) measurements were made with an Orion model TDS-1 meter and reported in parts per million. Conductivity was determined by a Sper Scientific SP-2 conductivity meter and reported in Siemens.

For each assay, instruments were calibrated and 35.0 mL of analyte water were added to a plastic weigh boat and placed on the surface tensiomat platform. Initial readings were taken with the tensiomat, TDS and conductivity meters. Sequentially one drop of Crystal Energy was added and subsequent readings of surface tension, TDS and conductivity were taken. This protocol was followed for two and four drops as well. Each analysis was performed with six replicates.

The results indicate a mean reduction in surface tension of 35% over the course of the assays. In each replicate and water type, the conductivity increased and the total dissolved solids increased. Increases in conductivity of up to 45% were observed in the treated waters. Increases in total dissolved solids up to 40% were also observed. The decrease in surface tension of 35% places most of the Crystal Energy® treated waters in the range of 43 to 47 dynes/cm clearly demonstrating the decrease in wetting angle and “wetness” of the waters. This range, as previously mentioned, is optimal for biological activity and maximized nutrient assimilation.

The increase in Total Dissolved Solids shows that many minerals in the water are being broken down to their smallest, dissolved states. This is further supported by the increases in conductivity which additionally promote better assimilation, nutrient transfer, and increases in reaction kinetics. Coupled together, the addition of the Crystal Energy creates an environment optimized for increased rates of nutrient assimilation as well as toxin removal from cellular structures!

Diffusion Kinetics: As a means to validate and understand the preceding results and to determine any increase in the speed of the fluids and differences in the diffusion kinetics, a second series of experimentations were executed that monitored the influx of a colored dye and vitamin C through a semi-permeable dialysis membrane over the course of several days. This environment best mimics the human cellular system and the dialysis membranes have similar diffusion properties to that of a human phospholipids cell.

To start the experimentation, 190 mL of analysis water were added to a Pyrex beaker. 10 mL of a 0.5 mg/mL solution of Red #5 food coloring and a 0.5 mg/mL vitamin C solution in their respective analysis waters were added to the 190 mL beaker. 10 mL of the analysis water were added to a wetted and tied 2 cm diameter dialysis tube and suspended in the solution. Treated waters were conditioned with 10 drops of Flanagan Crystal Energy®.

Readings were taken with a spectrophotometer initially and at the following intervals: 10 minutes, 20 minutes, 30 minutes, 1 hour, 4 hours, 24 hours and 48 hours. Spectra were taken from 340 to 700 nm and were blanked against the respective analysis water. Data were collected at 350 and 523 nm for the vitamin C and red #5 dye, respectively. Controls using tap, spring and distilled water and with both food coloring only and food coloring with vitamin c were used to verify the adsorption and quantification consistency of the vitamin c in solution.

The absorbance data (diffusion rates) showed a significant linear increase up to the 4 hour mark, at which time the diffusion rates slowed significantly and then leveled off by the 24 hour mark and maintained the concentration up to the end of the assay at 48 hours. The mean increase in diffusion rate between a Crystal Energy treated water and a non-treated water was 2.51 +/- 0.15 (Standard Deviation 0.003) times greater. These results clearly indicate a significant increase in fluid speed and nutrient absorption. This equates to an 80 times greater potential for nutrient carrying capacity. The significant increases in diffusion rate compared to controls demonstrate a profound ability of Crystal Energy® to aid in increasing the catalytic nutrient absorption properties of water .

CONCLUSION

Overall, all of the precision of the data were exceptionally consistent with each other clearly indicating: 1) A mean increase in the rate of nutrient flow across the membrane of 2.5 times over that of non-treated water. 2) A mean decrease in surface tension of 35%. 3) A mean increase in Total Dissolved Solids of 40%, and 4) A mean increase in conductivity of 45%.

All data indicated the requirements needed to optimize an environment for nutrient assimilation through decreased surface tension, wetting angle and increases in Total Dissolved Solids and conductivity were satisfied. Through the controlled monitoring of the diffusion of common water soluble vitamins, Crystal Energy® demonstrates the innate ability to act as a catalyst and aid in the increased rate of absorption in an in vitro, mock-cellular environment. The increase in absorption rates, coupled with its wetting properties, clearly demonstrate the Crystal Energy® conditions water to be highly optimized and essentially prepared for assimilation by the body.

 

REFERENCES

“Quantitative Analysis of Membrane Diffusion Kinetics and Surface Tension Differentiation by a Colloidal Silicate Minerals” by Cory J. Stephanson, PhD and G. Patrick Flanagan, MD, PhD.
From: http://phisciences.com/wp-content/uploads/Quantitative-Analysis-of-Membrane-7.pdf

Dr Gerald Pollack’s TED talk on water: https://www.youtube.com/watch?v=i-T7tCMUDXU
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