Looking for a natural energy boost? Or a super-power-up, pick-me-up drink? Look no further than Rejuvenate! Lemonade. Rejuvenate! Lemonade offers all the deliciousness of fresh lemonade with the energizing and health-boosting effects of Rejuvenate!™ (Original Greens), the first superfood formulated to provide high levels of dietary nucleic acids (RNA, DNA).
In fact, Rejuvenate Lemonade is among the best—and tastiest—ways to take Rejuvenate! Original Greens. I make 12–32 ounces of Rejuvenate! Lemonade daily. It is especially refreshing in the summer, but it easy to make and drink year-round. Not only does it taste amazingly good, but delivers the all important therapeutic levels of dietary nucleic acids you need daily for good health.
All three Rejuvenate! superfoods offer major energizing effects by providing therapeutic levels of dietary nucleic acids (RNA, DNA). Rejuvenate! superfoods are the only superfoods dedicated to supplying high levels of dietary nucleic acids. Yet, Rejuvenate!™ (Original Greens) is the most densely packed with dietary RNA, providing 340 mg per serving (one small scoop)!! A single container provides 42 servings—sufficient for six weeks of daily use.
MAKE REJUVENATE!™ LEMONADE
Make Rejuvenate! Lemonade with fresh lemons or limes, maple syrup (or other natural sweeteners), purified water, cayenne pepper (optional), and Rejuvenate!™ superfood. If you don’t have fresh lemons or limes, substitute bottled lemon juice (like the Santa Cruz brand organic 100% lemon or 100% lime juice).
REJUVENATE!™ LEMONADE RECIPE
Fresh Lemons or Limes (1–2) Purified Water (8–32 ounces) Grade B Maple Syrup (1–2 tbsp) Cayenne Pepper (1/4 tsp or pinch) Rejuvenate!™ (Original Greens) (1–4 scoops)
Squeeze the lemons (using a citrus juicer or press). Aim to squeeze 2–4 tbsp juice. Mix lemon juice into your container of water. Add 1–2 tbsp maple syrup or to taste. You can also try using stevia, xylitol, or other natural sweeteners. Add a pinch of cayenne pepper (optional). Mix 1–4 scoops of Rejuvenate! (Original Greens) superfood. In hot weather, try adding a few ice cubes. Stir and enjoy!
Rejuvenate! Lemonade is excellent when modified to include small amounts of other juices (e.g., blueberry or pomegranate) of your choice, or other Rejuvenate! superfoods (Rejuvenate! Plus or Rejuvenate! Berries & Herbs).
Rejuvenate!™ Original Greens is the most nutrient-dense, and darkest-green superfood in HPDI’s Rejuvenate! line.
These nutrients ensure the body effectively utilizes the dietary nucleic acids in Rejuvenate! Original Greens. They also help this unique high-RNA superfood support your health beyond what might be expected of the collection of individual nutrients—a process known as “synergy” that leverages the benefits of all ingredients in Original Greens into something more than the sum of its parts.
FINAL WORDS: WHY REJUVENATE! LEMONADE?
Rejuvenate!™ Original Greens was the first in the Rejuvenate! line of superfoods. More than the others, it is nutrient-dense in terms providing the richest amount of dietary nucleic acids per unit weight. It also remains the most cost-effective per serving.
While it does not contain a built-in multivitamin (like Rejuvenate! PLUS and Rejuvenate! Berries & Herbs) or a comprehensive herbal sub-formula (like Berries & Herbs), Rejuvenate!™ Original Greens remains most popular among “hard core” nutrition customers and healthy food purists, as well as individuals seeking the most rapid detoxification and cleansing effects. Does this sounds like you or your clients? Then start with “Original Greens,” make healthy RNA-rich lemonade, and enjoy all the tasty benefits!
The combination of fresh lemonade and Rejuvenate! Original Greens will help hydrate, cleanse, purify, and detox…and simply is a tasty and energy-boosting, power-up drink like no other!
Lemonade made with Rejuvenate! Original Greens packs a potent, high-RNA punch.
We previously published an article titled FOLATE INGREDIENTS – FOLINIC ACID & 5-MTHF in which we discuss how coenzyme folate vitamins are far superior to the synthetic folic acid form. In today’s article, I take a more in-depth look at how homocysteine is formed from methionine, how genetics affects the metabolic pathways, and how B vitamins are used in metabolic pathways.
One way to look at the metabolic pathways of methionine (an essential amino acid) is that it provides a way for the body to convert this sulfur containing amino acid either to cysteine and its key by-products glutathione, taurine, and sulfates or allows remethylation back to methionine to occur using either the Folate Cycle or the Trimethyl glycine (betaine) pathways.
Figure 1 shows these metabolic pathways including the vitamins required at each step including vitamin B6 (as P-5-P), methylcobalamin, and 5-methyltetrahydrofolate (5-MTHF). In addition, it shows the key enzymes produced by the body at each step. These enzymes include CBS (cystathione beta synthase), BHMT (betaine homocysteine methyltransferase), MS (methionine synthase), and MTHFR (methylene tetrahydrofolate reductase).
Figure 1. Metabolic Pathways in Methionine and Homocysteine Metabolism
HEALTH ISSUES ASSOCIATED WITH HIGH HOMOCYSTEINE LEVELS
It is highly important that the various metabolic pathways function correctly to keep homocysteine at healthy levels (6–8 µmol/L). Unfortunately, high levels of homocysteine in the body (10–20 µmol/L) are a factor in a wide range of health issues, including:
Greater risk for heart problems, including coronary artery disease, heart attacks, stroke, high blood pressure, congestive heart failure, and abnormal cholesterol levels. This is due to increased inflammation, sometimes due to blood clotting spontaneously, and because of blockages of the major arteries.
Mental abnormalities such as depression, anxiety, bipolar disorder, and other mental problems are more common among people with high homocysteine
Migraines and headaches in a significant percentage of the population
In those who suffer from high homocysteine due to having nutritional deficiencies anemia, aches and pains, hearing loss, age-related macular degeneration (ARMD), slowed development, and birth defects might also be possible
Greater risk for dementia, Alzheimer’s disease, brain atrophy, and other cognitive problems
In children, skeletal and developmental abnormalities including having a curved spine or protruding chest and rib cage. Some patients appear very tall and thin, and some might also have very long, thin “spider-like” toes and fingers.
Behavioral problems, including ADHD, autism and other learning disabilities
ROLE OF GENETICS IN HOMOCYSTEINE METABOLISM
Ten or more years ago, questions of how genetics enters into homocysteine metabolism were unlikely to be asked. However, in recent years DNA testing has advanced and is now available to everyone (for example, see my article about Bodysync’s genetic test, DISCOVERING NUTRITIONAL NEEDS THROUGH ADVANCED GENETIC TESTING.
You may have heard a great deal about MTHFR (methylene tetrahydrofolate reductase). This gene is involved in folate metabolism and has a central role in methylation processes like repair of and building new DNA in dividing cells.
In the remethylation pathway for conversion of homocysteine to methionine, MTHFR plays a key role in converting folate into 5-MTHF which is needed along with B12 as methylcobalamin in order for the conversion to take place. Genetic variations in MTHFR have been studied in depth. Of the many variations studies the most significant ones appear to be variations of C677C such as C677T (referred to as heterozygous) or T677T (referred to as homozygous). The heterozygous variant appears in about 30–50% of the population and causes somewhat less efficiency in the conversion of folic acid to 5-MTHF. However, the homozygous variation occurs in about 10% of the population and can have serious effects due to converting little homocysteine back to methionine.
Another variation in MTHFR is called A1298A. These variations are A1298C and C1298C and will have similar effects to the C677C variations. It was interesting to me when I recently analyzed my Bodysync genetic test results showing I carry the variation A1298C (heterozygous), which indicates I may not be effectively converting homocysteine back to methionine.
Additionally, my Bodysync genetic test results also indicate that I have heterozygous variations in the CBS enzyme shown in Figure 1, as well as heterozygous variations in MTR and MTRR enzymes, which are involved with B12 levels in the remethylation pathway. These results indicate that I need to take higher levels of methylcobalamin and 5-MTHF.
IMPORTANCE OF COENZYME FORMS AND PROPER AMOUNTS OF B VITAMINS
Many of the B vitamins on the market today unfortunately are in synthetic form. The body can only use the natural coenzyme forms effectively. For example, the body needs vitamin B6 in the form of P-5-P (pyridoxal-5-phosphate), folate in the form of L-5-MTHF, and B12 in the form of methylcobalamin for proper metabolism of methionine. In some cases the body can use the synthetic forms of pyridoxine HCl, folic acid, and cyanocobalamin but pays a cost (e.g., in time and energy) by having to convert synthetic forms to coenzyme forms.
Add to the prevalence of synthetic B vitamins, the fact that genetic deficiencies are more common than previously assumed, and it becomes clear that the coenzyme forms of B vitamins in the proper amounts are extremely important.
Fortunately, I have always believed it best to include as many coenzyme forms as possible in the nutritional supplements I formulate (over the past 27 years). For example, all HPDI multivitamins include coenzymes of B1, B2, B6, B12, and folate (as 5-MTHF and folinic acid). This is uncommon in most multivitamin formulas on the market. For this reason our supplements are ideally suited to the prevention or resolution of most genetic problems regarding homocysteine.
In addition, I have always chosen to include higher amounts than most multivitamins on the market. We also make available 5-MTHF one milligram (1 mg) capsules and methylcobalamin five milligram (5 mg) sublingual tablets. When genetic variations are in play as discussed above, then providing relatively higher amounts of coenzyme B vitamins that support important requirements in the body seems necessary.
Interestingly, several other nutrients are involved in the pathways involving methionine and homocysteine. These include zinc, magnesium, and Vitamin B2. Our multivitamin formulas and magnesium formulas, especially Myo-Mag with its coenzyme B1, B2, and B6, are recommended to support these nutrient needs. Finally, it has been found that N-Acetyl-L-Cysteine (NAC) can significantly lower homocysteine (by up to 50%), most likely because its gives the body an excellent source of cysteine without have to use methionine.
In this article, I have shown the value of the use of genetic testing and high-quality coenzyme B vitamins in resolving health issues associated with high values of homocysteine in the body.
Looking for a high-quality, natural KIDS MULTIVITAMIN? Me, too. Do you look in vitamin stores, natural foods stores, and online marketplaces—in vain? I have.
A couple years ago, HPDI’s formulator, my father Hank Liers, PhD decided to reformulate our already excellent kids multivitamin—the Kids Mighty-Multi!—to make it better. His intentions were good: the world’s best designer of adult multivitamins would improve the best children’s vitamin.
My quandary? While Dr. Hank was busy at work reformulating our kids multi, the existing—and uber-excellent—original Kids Mighty-Multi! went out-of-stock, and never came back. Suddenly, my seven-year-old son’s “go-to” multivitamin was gone…indefinitely!
I took action—kids vitamins became my obsession—because I wanted the best multivitamin for my child. I searched everywhere for high-quality kids vitamins. Leaving no stone unturned, we tried them all—including organic, whole food, gluten-free, vegan-friendly brands with glossy labels. Did we find good ones? Not really.
What DID we find? Well, not much—and a lot. That is, not much in the way of high potency, high-purity, or advanced forms, like coenzyme vitamins. And a lot of false promises and junk ingredients. Like sugar and corn syrup and GMO ingredients—even from “reputable” brands.
Not to mention artificial sweeteners, colorings, flavorings, as well as toxic preservatives and fillers, which are the de facto standard in conventional products. Natural products are better—not always by as much as you’d expect.
Looking for a good children’s multivitamin? Look no further than chewable Kids Mighty-Multi!
MY MULTIVITAMIN WISHLIST
Now in label-induced miasmic SHOCK…I proposed a reversal of terms. I simply wanted a lot of good things—like complete, balanced nutrients—and not much in the way of toxic additives.
Reeling, I scrawled a brief manifesto or “wishlist” for my ideal kids multivitamin:
“Great taste, high-purity, balanced nutrients at optimal levels, chewable; sugar free, non-GMO. No artificial ingredients, especially toxic sweeteners like aspartame or sucralose. No harmful additives or preservatives like sodium benzoate, BHT, or propylene glycol (no antifreeze please!); a few good-for-you functional ingredients.”
Was I asking *too* much? No way. Yet, I was giving up on finding a suitable kids multivitamin. My son instead began taking an HPDI adult multivitamin (Multi Two Caps) we scaled to his sixty five-pound weight. The taste wasn’t great—so we opened capsules directly into his juices and smoothies—because he’s not ready to swallow capsules or tablets whole. At best…a partial solution.
KIDS MIGHTY-MULTI! BACK — BETTER THAN EVER!
Then. It. Happened. Lighting struck—HPDI’s Kids Mighty-Multi! is BACK! Turns out my dad finished reformulating the world’s best kids multivitamin. He broke the news with a smile. Stunned and unbelieving…I took a breath. My heart skipped a beat. Then I grabbed a bottle!
Who knew it would take two years?—and now, who cares!? This month, HPDI proudly introduces a *new* Kids Mighty Multi!. Worth the wait? Yes. Because the new version is better than ever.
I’ve thrown away my wishlist. My search is over. Yours may be, too. Because no kids multivitamin comes *close* to Kids Mighty-Multi!. See the comparison chart and nutrient table (below).
A SERIOUS VITAMIN FOR KIDS – FINALLY!
What makes the new Kids Mighty-Multi! so good, and so much better? Let me count the ways. Here is a summary of benefits before I dive into discussing them in greater detail.
• Kids and adults love the taste!
• Full-spectrum of balanced, essential nutrients needed for creating, supporting, and maintaining excellent health for your child. Includes natural coenzyme form vitamins and Krebs’ cycle bionutrients that work with young bodies to provide energy for metabolic processes, healing, and optimal health.
• Bioavailable vitamin and mineral carriers the body recognizes and can assimilate rapidly. Plus, multiple carriers of individual nutrients ensure assimilation. Chewable form speeds uptake in the body.
• Variety of well-known herbal ingredients, including quercetin, grape extract, turmeric, broccoli powder, and octacosanol
• Complete, balanced supply of carotenoids, including beta-carotene, lycopene, and lutein
• Functional ingredients built into every aspect of the formula, including the taste-enhancing package, herbal ingredients, and cofactors. Functional ingredients serve multiple purposes in supporting health.
• Flavored using only healthy, natural sweeteners and taste enhancers, including mannitol, fructooligosaccharides (FOS) (from chicory root), organic beet root powder, natural fruit flavor, xylitol, and stevia leaf extract. Taste enhancers exhibiting additional positive benefits (i.e., prebiotic effects, cavity prevention, and antioxidant action).
• NO refined sugars, no corn syrup, and…NO GMOs!
• NO artificial colorings or flavorings, artificial sweeteners (like aspartame, saccharin, or sucralose), or hydrogenated vegetable oils
• Excludes common food source allergens like wheat, corn, soy, and dairy
• Excludes unnecessary excipients, including fillers, binders, and additives
• Foundational formula ideal for providing basic nutrients for health. A high-quality multivitamin is the first step toward a complete nutritional supplement regimen. Formulated to work well with other HPDI foundational formulas, such as vitamin C / antioxidant formulas (like PRO-C™) and essential fatty acids (like Essential Fats plus E).
TASTE-ENHANCING COMPLEX: FUNCTIONAL INGREDIENTS
Kids Mighty-Multi! tastes GREAT! Kids and adults LOVE the taste. From the perspective of your child’s taste buds, that’s *all* that matters.
But I want to talk a bit about the importance of healthy sweeteners…and how the best sweeteners perform double duty as health promoters.
WHY does Kids Mighty-Multi! taste so good? (Did I mention it contains NO refined sugars—or any artificial sweeteners or flavorings?)
Because Dr. Liers created a natural taste-enhancing complex. This taste-enhancing package includes xylitol, mannitol, FOS (fructooligosaccharides), beet root juice powder, natural fruit flavors, and stevia leaf extract.
Dr. Hank selected healthy, functional ingredients—as much as possible—in order to enhance the taste. That means these taste enhancers are not only NOT unhealthy like the refined sugars, corn syrups, and artificial sweeteners I found in so many other kids vitamins. But they are GOOD for you!
• Mannitol – Natural polyol sweetener with added benefits as an antioxidant. Mannitol surprisingly has a very powerful effect on the hydroxyl free-radical. (see: https://www.ncbi.nlm.nih.gov/pubmed/9090754). Mannitol serves double duty as a healthy sweetener and important hydroxyl radical free-radical trapper.
• Fructooligosaccharides (FOS) (from chicory root) – Naturally sweet with no or low glycemic index. It is also a prebiotic that supports the growth of beneficial bacteria.
• Beet Root Powder (organic) – Naturally sweetens and colors Kids Mighty-Multi!. Beet is a functional ingredient providing methyl donors and easily assimilable iron. Moreover, Dr. Benjamin S. Frank found beets contain an amino acid the body uses to create its own dietary nucleic acids and a nutrient important to brain function (No-Aging Diet, 81).
• Berry & Fruit Extracts / Flavors – Mixed berry, strawberry, raspberry, and pomegranate. These berry extracts provide extremely good, fruity taste—bursting with berry flavors!
• Stevia Extract – Natural sweetens with little or no glycemic value. Kids Mighty-Multi! contains a newer, improved stevia extract which is de-bittered
• Malic Acid – Provides a naturally tart taste, supports the utilization of magnesium, and feeds into the Krebs’ cycle that makes cellular energy (ATP)
Why is choosing “good-for-you” functional sweeteners and taste enhancers important?
Because despite what adults might wish, sweeteners still comprise the largest percentage of kids multivitamins by weight. That means your child will be ingesting significant amounts (of whatever these sweeteners are) relative to the size of their multivitamin.
Who wants the bulk of their child’s multivitamin intake comprised of sugars, corn syrup, sucralose, or worse (think aspartame)? This is the reason natural sweeteners providing functional benefits make all the difference for health.
COMPLETENESS MATTERS – A LOT!
Kids Mighty-Multi! is nothing if not complete. As formulated by Dr. Hank Liers, it provides therapeutic levels of all essential vitamins, minerals, cofactors, and much more.
If you read labels (like I do), you’ll see most kids vitamins are “hit-or-miss.” They provide certain nutrients, but often completely miss others—usually with no rhyme or reason. (What was its formulator thinking?)
Missing important nutrients is bad for consumers—like you and your child—because all nutrients require other nutrients to “do a body good.” It’s called synergy, and it’s the way our cells are designed to work.
That means if you obtain sufficient amounts of a specific nutrient, but not enough of another, you may be unable to effectively utilize the nutrient you have—because utilization requires the nutrient you *don’t* have. Catch-22, huh? I’ll talk more about this later.
Do your child—and yourself—a favor: choose a complete multivitamin like Kids Mighty-Multi!.
Kids Mighty-Multi! is nothing if not COMPLETE. (Tablets in photo appear larger than actual size.)
ADVANCED FORMS OF NUTRIENTS…LIKE YOU’VE NEVER SEEN
Then, there are advanced forms of nutrients, like coenzyme B vitamins. Most kids vitamins (and adult multivitamins) offer you the B complex vitamins as synthetic forms. How can you tell? Well, coenzyme vitamin B1 in Kids Mighty-Multi! is from Thiamin Diphosphate and is very different from synthetic “thiamine HCl.” Vitamin B2 is from Riboflavin-5′-Phosphate is not synthetic “riboflavin.” The vitamin B6 is from Pyridoxal-5′-Phosphate is not “pyridoxine HCl.” And so on.
What about vitamin B12 as toxic “cyanocobalamin”? Never. Kids Mighty-Multi! provides coenzyme B12 as methylcobalamin. Other brands sometimes use this form, but then provide synthetic forms for other B vitamins. That makes sense—NOT.
Sure, coenzyme B vitamins cost more to source. But the truth is, your body requires far less coenzyme form vitamins because they are the natural forms found in foods—you easily assimilate and utilize them. Kids Mighty-Multi! doesn’t need large amounts of coenzyme vitamins to give you big benefits.
Meanwhile, synthetic forms are not as easily assimilated—most go through a complex enzymatic breakdown before the body can use them. In some cases (for example if your child lacks certain enzymes due to genetics), syntethic forms cannot be broken down—or used—at all!
Case in point: Folate. Most kids vitamins give you “folic acid,” which is synthetic vitamin B1. A large percentage of the population (including me) lacks the gene providing the enzyme required to process folic acid. If folic acid builds up in cells (because it can’t be broken down), then it can be toxic. Solution: we use coenzyme folate—or 5-MTHF (5-methyl tetrahydrofolate) in Kids Mighty-Multi!. Problem solved.
Recall I said Kids Mighty-Multi! is complete?—and the importance of completeness in a multivitamin? Well, for example, if your kids’ multivitamin only provides synthetic vitamin B6 (as Pyridoxine HCl), it won’t be convertable into its biologically active (coenzyme) form without coenzyme vitamin B1 (Riboflavin-5′-Phosphate).
Did you catch that? To convert Pyridoxine HCl (synthetic vitamin B6) to its usable coenzyme form Pyridoxal-5′-Phosphate, you need coenzyme Riboflavin (Riboflavin-5′-Phosphate). You need a coenzyme form of one B vitamin in order to convert another B vitamin to its coenzyme form!
If you have only synthetic forms of these B vitamins, your body must go through multiple conversion processes in order to first convert synthetic Riboflavin into coenzyme Riboflavin so that you can convert synthetic vitamin B6 (Pyridoxine HCl) into its coenzyme B6 form (Pyridoxal-5′-Phosphate).
Yes, you can *survive* on synthetic forms of B vitamins. But why make your body work so hard? Why survive when you can *thrive* (with coenzyme vitamins)?
Why other kids vitamins don’t include coenzyme forms is BEYOND ME. If other brands go with conventional (and sometimes toxic) synthetic forms, so be it. Run, and go with Kids Mighty-Multi!.
Other advanced forms include vitamin D as D3 (cholecalciferol), vitamin K as K1 and K2 (Menaquinone-7), and minerals using Krebs’ cycle carriers (like citrates, malates, fumarates, succinates, and aspartates) that are best recognized and utilized in the body because they plug into the body’s energy (ATP) production system.
KIDS MIGHTY-MULTI!™ NUTRIENT TABLE
% Daily Value
(as beta-carotene from Dunaliella salinas)
(from potassium, magnesium, and calcium ascorbates)
Vitamin D3 (as cholecalciferol)
Vitamin E (from d-alpha tocopheryl succinate and 5 mg natural mixed tocopherols)
Vitamin K (10 mcg as phylloquinone (K1) and 5 mcg as MK-7 (K2))
Vitamin B1 (from thiamin diphosphate)
Vitamin B2 (from riboflavin-5′-phosphate)
Vitamin B3 (80% from niacinamide and 20% from niacin)
Pantothenic Acid (from calcium pantothenate)
Vitamin B6 (from pyridoxal-5′-phosphate)
Vitamin B12 (as methylcobalamin)
Folate (from 5-MTHF – Quatrefolic®†)
Biotin (pure crystalline)
Magnesium (from malate)
Calcium (from Krebs cycle bionutrients)
Potassium (from citrate)
Zinc (from citrate)
Iron (from fumarate)
Manganese (from citrate)
Copper (from aspartate)
Chromium (from polynicotinate)
Molybdenum (from citrate)
Selenium (from l-selenomethionine)
Choline (from bitartrate)
Inositol (pure crystalline)
Quercetin (as dihydrate)
Turmeric (from Curcuma longa) (root)
Broccoli Sprouts Powder
Grape Extract (Vitis vinifera) (from seed, skin, and stem)
Lycopene (tomato extract) (fruit)
Boron (from glycinate and aspartate)
Lutein (from Calendula officinalis) (flower)
Octacosanol (from policosanol)
Vanadium (from BGOV – bis glycinato oxo vanadium)
* No established Daily Value
† Quatrefolic® is a registered trademark of Gnosis SPD
SCALABLE DOSING – CALLING ALL KIDS – AND ADULTS!
Maybe the best feature of Kids Mighty-Multi! is scalable dosing. Scalability makes it suitable for children and youth of all sizes—and adults, too!
Glancing at Kids Mighty-Multi!‘s label, you might assume it’s as low potency as the most kids’ vitamins available in stores. Not so fast.
Because Dr. Hank designed this multivitamin for everyone, including adults. How do I know? Because he told me: he takes these chewables himself!
How does it work? You simply take two (2) tablets per 20 pounds of body weight—up to six tablets—for kids. But since most older kids and adults weigh more than 60 pounds, you can take 8–10+ tablets and approximate the nutrition you would get from your regular adult vitamin. How cool is that!
Scalable dosing works well for people who don’t like swallowing capsules or tablets, or who prefer a good-tasting chewable. And who doesn’t, sometimes? It is especially useful for traveling because the entire family can use it.
In my case, I usually take four capsules per day of Hank & Brian’s Mighty Multi-Vite! , which my favorite adult multivitamin, and the inspiration for creating the Kids Mighty-Multi!. Yet, there are many days when I thrill to the taste of the new chewable kids multivitamin—knowing I get a significant amount of nutritional value. That means a lot. A lot of goodness. And not much to worry about.
Dr. Hank Liers pulled out the stops in formulating Kids Mighty-Multi!
CHOOSE KIDS MIGHTY-MULTI!
You’ve got choices. You can go online or to your local natural market, pharmacy, or big box store and fill up on whatever kids vitamins you find. Take your chances. Or you can try Kids Mighty-Multi! to discover how good a children’s multivitamin can (and should) be—a truly superior formula.
Choose our awesome kids multivitamin. Dr. Hank did his job. We’re 110% confident it meets—or exceeds—the needs and expectations of your child, and likely you, too. And definitely those of your clients, if you’re a health professional.
Of course, you’ve got a brain. But this choice is a “no-brainer.” Go for Kids Mighty Multi!. Your kids will never go back to their old multivitamin. And they’ll be healthier for it.
Ultimate Protector™ contains freeze dried strawberries, as well as components from 29 different fruits, vegetables, and herbs. Each of these ingredients contain substances that may be considered to be polyphenols, antioxidants, and Nrf2 activators. In this article I explore the ingredient strawberries, which is a component of VitaBerry Plus® from Futureceuticals.
VitaBerry® (N1023) is the trade name for a line of high ORAC blends of fruit powders and fruit extracts, exclusively available through FutureCeuticals.
VitaBerry® is a proprietary formula that combines wild bilberry and wild blueberry, cranberry, raspberry, strawberry, prune, cherry, and grape whole powders and extracts into lines of custom blends. High in fruit polyphenols, anthocyanins, proanthocyanins, ellagic acid, chlorogenic acid, resveratrol, and quinic acid, VitaBerry offers 6,000 ORAC units in a single gram.
VitaBerry® Plus (N81.3) combines the standard blend of VitaBerry® with resveratrol and quercetin to deliver a minimum of 12,000 ORAC units per gram.
HEALTH BENEFITS OF STRAWBERRIES
Strawberries long have grown wild in the world’s temperate regions. They have been cultivated for several thousand years and were prized among the ancient Romans. Most of the common varieties of strawberry derive from a hybrid (Frangaria x ananassa). Strawberries have an ORAC value of 1,540, which is very high among the fruits and vegetables tested by the USDA.They are a good source of vitamins C, K, B2, B5, B6, and folate. They also contain appreciable amounts of the minerals manganese, iodine, and potassium, as well as dietary fiber.
Like other berries, the antioxidants contained in strawberries may be useful against diseases of the heart and arteries by preventing the oxidation of lipids. The phytonutrient phenols most abundant in strawberries are anthocyanins and ellagitannins. The anthocyanins help to prevent oxidative damage from free radicals in body. The unique phenol profile of the strawberry enables it not only to protect the heart, but also to fight inflammation. Studies have shown that strawberries also protect the brain from oxidative stress and may therefore reduce age-related cognitive decline in brain function. Strawberries have been shown to be Nrf2 activators that can stimulate the endogenous production of protective enzymes in the body.
Here is a list of the antioxidant and anti-inflammatory phytonutrients in found in strawberries.
Emerging research provides substantial evidence to classify strawberries as a functional food with several preventive and therapeutic health benefits. Strawberries, a rich source of phytochemicals (ellagic acid, anthocyanins, quercetin, and catechin) and vitamins (ascorbic acid and folic acid), have been highly ranked among dietary sources of polyphenols and antioxidant capacity. It should however be noted that these bioactive factors can be significantly affected by differences in strawberry cultivars, agricultural practices, storage, and processing methods: freezing versus dry heat has been associated with maximum retention of strawberry bioactives in several studies. Nutritional epidemiology shows inverse association between strawberry consumption and incidence of hypertension or serum C-reactive protein; controlled feeding studies have identified the ability of strawberries to attenuate high-fat diet induced postprandial oxidative stress and inflammation, or postprandial hyperglycemia, or hyperlipidemia in subjects with cardiovascular risk factors. Mechanistic studies have elucidated specific biochemical pathways that might confer these protective effects of strawberries: upregulation of endothelial nitric oxide synthase (eNOS) activity, downregulation of NF-kB activity and subsequent inflammation, or inhibitions of carbohydrate digestive enzymes. These health effects may be attributed to the synergistic effects of nutrients and phytochemicals in strawberries. Further studies are needed to define the optimal dose and duration of strawberry intake in affecting levels of biomarkers or pathways related to chronic diseases.
Bioactive Compounds and Antioxidant Activity in Different Types of Berries
Berries, especially members of several families, such as Rosaceae (strawberry, raspberry, blackberry), and Ericaceae (blueberry, cranberry), belong to the best dietary sources of bioactive compounds (BAC). They have delicious taste and flavor, have economic importance, and because of the antioxidant properties of BAC, they are of great interest also for nutritionists and food technologists due to the opportunity to use BAC as functional foods ingredients. The bioactive compounds in berries contain mainly phenolic compounds (phenolic acids, flavonoids, such as anthocyanins and flavonols, and tannins) and ascorbic acid. These compounds, either individually or combined, are responsible for various health benefits of berries, such as prevention of inflammation disorders, cardiovascular diseases, or protective effects to lower the risk of various cancers. In this review bioactive compounds of commonly consumed berries are described, as well as the factors influencing their antioxidant capacity and their health benefits.
Dietary intakes of berries and flavonoids in relation to cognitive decline
Objective: Berries are high in flavonoids, especially anthocyanidins, and improve cognition in experimental studies. We prospectively evaluated whether greater long-term intakes of berries and flavonoids are associated with slower rates of cognitive decline in older women.
Methods: Beginning in 1980, a semiquantitative food frequency questionnaire was administered every 4 years to Nurses’ Health Study participants. In 1995–2001, we began measuring cognitive function in 16,010 participants, aged ≥70 years; follow-up assessments were conducted twice, at 2-year intervals. To ascertain long-term diet, we averaged dietary variables from 1980 through the initial cognitive interview. Using multivariate-adjusted, mixed linear regression, we estimated mean differences in slopes of cognitive decline by long-term berry and flavonoid intakes.
Results: Greater intakes of blueberries and strawberries were associated with slower rates of cognitive decline (eg, for a global score averaging all 6 cognitive tests, for blueberries: p-trend = 0.014 and mean difference = 0.04, 95% confidence interval [CI] = 0.01–0.07, comparing extreme categories of intake; for strawberries: p-trend = 0.022 and mean difference = 0.03, 95% CI = 0.00–0.06, comparing extreme categories of intake), after adjusting for multiple potential confounders. These effect estimates were equivalent to those we found for approximately 1.5 to 2.5 years of age in our cohort, indicating that berry intake appears to delay cognitive aging by up to 2.5 years. Additionally, in further supporting evidence, greater intakes of anthocyanidins and total flavonoids were associated with slower rates of cognitive decline (p-trends = 0.015 and 0.053, respectively, for the global score).
Interpretation: Higher intake of flavonoids, particularly from berries, appears to reduce rates of cognitive decline in older adults.
Addition of strawberries to the usual diet decreases resting chemiluminescence of fasting blood in healthy subjects-possible health-promoting effect of these fruits consumption
OBJECTIVE: Regular strawberry consumption augmented plasma antioxidant activity and decreased lipid peroxidation suggests preventive potential of these fruits against oxidative stress-dependent disorders. Blood phagocytes are important source of oxidants that may contribute to systemic oxidative stress. We examined the effect of strawberry consumption on the luminol enhanced whole blood chemiluminescence (LBCL) reflecting oxidants generation by circulating phagocytes in healthy subjects.
METHODS: Thirty-one healthy subjects (being on their usual diet) consumed 500 g of strawberry pulp daily (between 11.00-14.00) for 30 days (1st strawberry course) and after 10 day wash-out the cycle was repeated (2nd strawberry course). Fasting blood and spot morning urine samples were collected before and after each strawberry course for measuring resting and agonist (fMLP)-induced LBCL, various phenolics and plasma antioxidant activity. Twenty subjects served as a control in respect to LBCL changes over the study period.
RESULTS: Strawberry consumption decreased median resting LBCL and this effect was more evident after the 1st course (by 38.2%, p < 0.05) than after the the 2nd one (18.7%), while fMLP-induced LBCL was constant. No changes in LBCL were noted in controls. Strawberries increased fasting plasma levels of caffeic acid and homovanillic acid as well as urolithin A and 4-hydroxyhippuric acid in spot urine. Plasma antioxidant activity and the number of circulating phagocytes did not change over the study period. Resting LBCL correlated positively with the number of circulating polymorphonuclear leukocytes at all occasions and negative correlation with plasma 4-hydroxyhippuric acid was noted especially after the first strawberry course (r = -0.46, p < 0.05).
CONCLUSIONS: The decrease in resting LBCL suggests that regular strawberry consumption may suppress baseline formation of oxidants by circulating phagocytes. This may decrease the risk of systemic imbalance between oxidants and anti-oxidants and be one of mechanisms of health-promoting effect of these fruits consumption.
Consumption of strawberries on a daily basis increases the non-urate 2,2-diphenyl-1-picryl-hydrazyl (DPPH) radical scavenging activity of fasting plasma in healthy subjects
Strawberries contain anthocyanins and ellagitanins which have antioxidant properties. We determined whether the consumption of strawberries increase the plasma antioxidant activity measured as the ability to decompose 2,2-diphenyl-1-picrylhydrazyl radical (DPPH) in healthy subjects. The study involved 10 volunteers (age 41 ± 6 years, body weight 74.4 ± 12.7 kg) that consumed 500 g of strawberries daily for 9 days and 7 matched controls. Fasting plasma and spot morning urine samples were collected at baseline, during fruit consumption and after a 6 day wash-out period. DPPH decomposition was measured in both deproteinized native plasma specimens and pretreated with uricase (non-urate plasma). Twelve phenolics were determined with HPLC. Strawberries had no effect on the antioxidant activity of native plasma and circulating phenolics. Non-urate plasma DPPH decomposition increased from 5.7 ± 0.6% to 6.6 ± 0.6%, 6.5 ± 1.0% and 6.3 ± 1.4% after 3, 6 and 9 days of supplementation, respectively. The wash-out period reversed this activity back to 5.7 ± 0.8% (p<0.01). Control subjects did not reveal any changes of plasma antioxidant activity. Significant increase in urinary urolithin A and 4-hydroxyhippuric (by 8.7- and 5.9-times after 6 days of supplementation with fruits) was noted. Strawberry consumption can increase the non-urate plasma antioxidant activity which, in turn, may decrease the risk of systemic oxidants overactivity.
One-month strawberry-rich anthocyanin supplementation ameliorates cardiovascular risk, oxidative stress markers and platelet activation in humans
Strawberries are an important fruit in the Mediterranean diet because of their high content of essential nutrients and beneficial phytochemicals, which seem to exert beneficial effects in human health. Healthy volunteers were supplemented daily with 500 g of strawberries for 1 month. Plasma lipid profile, circulating and cellular markers of antioxidant status, oxidative stress and platelet function were evaluated at baseline, after 30 days of strawberry consumption and 15 days after the end of the study. A high concentration of vitamin C and anthocyanins was found in the fruits. Strawberry consumption beneficially influenced the lipid profile by significantly reducing total cholesterol, low-density lipoprotein cholesterol and triglycerides levels (-8.78%, -13.72% and -20.80%, respectively; P<.05) compared with baseline period, while high-density lipoprotein cholesterol remained unchanged. Strawberry supplementation also significant decreased serum malondialdehyde, urinary 8-OHdG and isoprostanes levels (-31.40%, -29.67%, -27.90%, respectively; P<.05). All the parameters returned to baseline values after the washout period. A significant increase in plasma total antioxidant capacity measured by both ferric reducing ability of plasma and oxygen radical absorbance capacity assays and vitamin C levels (+24.97%, +41.18%, +41.36%, respectively; P<.05) was observed after strawberry consumption. Moreover, the spontaneous and oxidative hemolysis were significant reduced (-31.7% and -39.03%, respectively; P<.05), compared to the baseline point, which remained stable after the washout period. Finally, strawberry intake significant decrease (P<.05) the number of activated platelets, compared to both baseline and washout values. Strawberries consumption improves plasma lipids profile, biomarkers of antioxidant status, antihemolytic defenses and platelet function in healthy subjects, encouraging further evaluation on a population with higher cardiovascular disease risk.
Impact of strawberries on human health: insight into marginally discussed bioactive compounds for the Mediterranean diet
OBJECTIVE: To review and update the current knowledge on the potential impact of strawberry on human health, with particular attention on compounds and indirect mechanisms of action not exhaustively considered.
DESIGN: Personal perspectives and recent data.
RESULTS: Our research group was among the few groups that have recently investigated the folate content in fresh, stored and processed strawberries, and the data look very promising. As well, some in vivo evidence of the impact of strawberry intake on the folate status in humans have already been reported, but a new increasing interest on this field is strongly hoped. Furthermore, the hypouricaemic effects previously ascribed to cherry consumption need to be evaluated in respect to strawberry intake. At the moment, inconsistent results come from the few investigations designed at this proposal. In our studies, a great interindividual variability was observed on plasma urate levels in response to strawberry intake, suggesting a putative effect.
CONCLUSIONS: The mechanisms responsible for the potential health-promoting effects of strawberry may not be necessarily searched in the activity of phytochemicals. Particularly, a greater interest should be addressed to show whether a prolonged strawberry consumption may effectively improve the folate status and reduce the incidence of folate-related pathological conditions. Furthermore, the hypouricaemic effects of cherries need to be evaluated also in respect to strawberry intake, and the mechanisms of actions and anti-gout potentialities need to be studied in detail. Future investigations involving human trials should be aimed at following these underestimated scientific tracks.
Strawberries are an important fruit full of polyphenols, anthocyanins, antioxidants, and Nrf2 activators that help to make Ultimate Protector such an outstanding nutritional supplement.
We frequently receive questions about our products and share the answers with you on our blog. If you have questions please e-mail us at support(at)integratedhealth.com. We will answer your questions directly, and likely include your question and our answer in a future products FAQ blog article.
Q. How Much Protein is in Rejuvenate! Plus and What are the Sources?
A. The protein (11.7 gm total per serving) profile in Rejuvenate! Plus is 30% rice protein (organic & non-GMO), 16% vegetable sprouts/pea protein (organic), 11% hemp protein (organic), 11% protein from chlorella, 9% protein from alfalfa grass, 7% from spirulina (Hawaii Pacifica), 6% from flax seeds (organic), 3% from nutritional yeast, and the rest from miscellaneous other ingredients. This is a beautiful blend of a large number of healthy protein sources!!
The rice protein we do use amounts to 5.0 gm per 31 gram serving and is a blend of 80% Orzatein (organic) from China and 47.5% non-gmo grown in California. The net amount of the 80% orzatein (organic) from China in the product is 3.3 grams (a small amount!). Please be advised that we routinely test Rejuvenate! Plus for heavy metals and have never seen significant amounts of any heavy metals.
Personally, four members of my family including me take 1 or 2 servings of Rejuvenate! Plus daily and have done so for many years with excellent results. We are very particular about the foods we put in our body!!
Q. What are the Sources of Enzymes, Soy, and Vitamin D3 in Rejuvenate! Plus?
A. The enzymes are plant based. Protease Enzymes from Aspergillus oryzae ferment. Cellulase Enzymes from Trichoderma oryzae ferment. Alpha-Galactosidase enzymes from Aspergillus niger ferment. CereCalase enzymes (contains hemicellulase, beta-glucanase & phytase) from Aspergillus niger ferment.
The product contains d-alpha tocopheryl succinate. This ingredient is characterized as “soy-antigen free” because of the way it is processed. PCR testing reveals no soy protein even though it originally comes from soy. High-gamma mixed tocopherols is characterized as “soy-antigen free” because of the way it is processed. PCR testing reveals no soy protein even though it originally comes from soy.
The Vitamin D3 is extracted from lanolin. Lanolin is extracted from wool (sheep).
Q. What Form of Vitamin B3 is in Rejuvenate! Plus and will It Cause Flushing?
A. There is 40 mg of the B3 in Rejuvenate! Plus as niacinamide. This form of B3 will not cause flushing.
Q. What Part of the Aloe Vera Plant is in Your Rejuvenate Plus Product?
A. Rejuvenate! Plus contains Organic ActivAloe® 200:1 from gel that is made into a powder.
Q. Do Your Rejuvenate! Products Contain Any Nut or Soy Allergens?
A. I checked with the manufacturer and was assured that there is no soy or nut allergens in the Rejuvenate, Rejuvenate Plus, or Rejuvenate Berries & Herbs products.
Q. How Do You Make Rejuvenate! Original Lemonade?
A. Rejuvenate! Original lemonade consists of one scoop of Rejuvenate! Original, 2–3 tablespoons of organic lemon juice (fresh or Santa Cruz brand), and 2–3 tablespoons of organic grade B maple syrup. Put these ingredients in a one-quart glass Mason jar and fill with purified water (and maybe some ice made from purified water). Some people like to add a bit of cayenne. This is a great summertime drink!
Q. How Much Rice Bran Oil is in Complete E?
A. There is approximately 250 mg of rice bran oils per capsule in addition to the Vitamin E. The profile of fatty acids is approximately 38% monounsaturated, 37% polyunsaturated, and 25% saturated fatty acids. This amounts to about 100 mg of polyunsaturated fatty acids per capsule. Very little, but useful!
Q. I Want to Know More About the Black Soybean Hull Extract in Ultimate Protector.
A. Black soybean hull extract contains a high percentage of polyphenols (greater than 60% and as high as 100%) including 10–45% anthocyanidins, 10–25% catechins, and 40–80% OPC. There is unlikely to be any soy protein or phytoestrogens in the product due to the extraction processes used. (See: http://www.google.com/patents/US8206764).
Q. I Want to know How Much Caffeine is in Ultimate Protector.
A. A study done on CoffeeBerry extract shows a 0.44% caffeine content. Since each capsule contains 45 mg of the extract the amount of caffeine per capsule is about 0.2 mg (or 1.2 mg per serving of 6 capsules). (See: http://www.nutritionaloutlook.com/news/study-compares-higher-antioxidant-coffee-fruit-extract-coffee-powder).
Q. I Want to Know More About the Blue Corn Extract in Ultimate Protector, and if it contains aspergillus mold.
A. Ultimate Protector contains an extract of blue corn optimized for the anthocyanidin content. Due to the extraction process, it is unlikely that the final material contains any aspergillus. Also, since there is only a small amount of blue corn extract in the product (I estimate less than 5 mg per capsule) it is even more unlikely that aspergillus is a problem.
Q. Does the Vitamin C in Ultimate Protector contain Genetically Modified Organisms (GMOs)?
A. The process of producing Vitamin C involves using the starting material of d-glucose derived from plant materials such as corn, beets, potatoes, cassava, etc. (See: http://en.wikipedia.org/wiki/Reichstein_process). Each of these starting materials will contain some protein that could be in part from genetically modified materials. In most cases—especially in the production of USP grade materials that we use in Ultimate Protector™—the protein will be completely removed. As a precaution that no genetically modified protein remains, PCR testing is conducted (See: http://www.nongmoproject.org/product-verification/about-gmo-testing/guidelines/). The Vitamin C we use in Ultimate Protector™ has been tested using this method, and is certified by independent laboratories to contain no GMOs.
Q. Is There Any Vitamin E in Ultimate Protector Product?
A. There is no Vitamin E in Ultimate Protector. The Vitamin C per cap is 250 mg which is 415% of the Vitamin C RDA. Once in the body, the Vitamin C is able to regenerate oxidized Vitamin E to its unoxidized form. The other main ingredients in Ultimate Protector are plant-based antioxidants (external) and other plant-based substances (called Nrf2 activators) that stimulate the body to make it own antioxidants (internal). In this regard, it is a very powerful supplement!
Q. What are the Plant Sources in Ultimate Protector that provide High ORAC5.0 Values?
A. There are six ingredients that provide high ORAC values. Three of these ingredients (AnthoComplete®, VitaBerry® Plus, and VitaVeggie®) are a mixture of extracts from a wide range of fruits and vegetables. Below each of the ingredients are listed along with website/product information:
1) AnthoComplete® from Futureceuticals (http://www.futureceuticals.com/products/anthocomplete™),
2) CoffeeBerry® Forte from Futureceuticals (http://www.futureceuticals.com/products/coffee-fruit),
3) VitaBerry® Plus from Futureceuticals (http://www.futureceuticals.com/products/vitaberry®),
4) VitaVeggie® from Futureceuticals (http://www.futureceuticals.com/products/vitaveggie®).
5) Resveratrol (98% min.) is derived from the Giant Knotweed (Polygonum cuspidatum)
6) Curcumin (95% min. curcuminoids) from Sabinsa (http://www.sabinsa.com/products/standardized-phytoextracts/c3/)
All of these sources are non-GMO. None of our sources claim organic. This in part may be because they are extracts and as such may have been processed in a manner not considered to be organic. Please consider that this is a nutritional supplement and not a food.
Q. What Form of 5-MTHF Do You Use in Your Products?
A. We use only the Quatrefolic form of folate made by the Italian company Gnosis. See: http://www.quatrefolic.com/4thGeneration.html. This contains only the active non-racemic form of folate and no folic acid. Quatrefolic®, provides the metabolic reduced form utilized and stored in the human body – (6S)-5-methyltetrahydrofolate.
Q. Why is the Number of Organisms in Your Prescript-Assist™ Formula Low Compared to Other Probiotics?
A. It turns out that it’s an example of the old story of trying to compare apples to oranges. SBO (soil-based organisms), the type found in Prescript Assist, are much more hardy and not destroyed as easily by pH differences in your stomach and intestines like the traditional lactic acid probiotics that have crowded the refrigerators in health food stores for many years.
Have you noticed that in recent years typical probiotics have gone from 5–10 million CFUs (Colony-Forming Units) to 30–50 million CFUs? Why are all of these probiotic formulas competing on this level? Because lactic-acid based probiotics are killed off by the millions on their journey through your stomach acids and the pH changes in the intestines. Very few make it to their intended target and even fewer colonize there very well once they make it compared to the sturdier SBOs.
Soil-Based Organisms (SBO) are extremely hardy and can make this journey with far, far more organisms colonizing their target. They also do not degrade when kept at room temperature for many months. They do not have to be refrigerated like the traditional lactic acid probiotics, which lose their potency and effectiveness quickly when left unrefrigerated or when they are shipped through the mail without dry ice.
Prescript-Assist goes even a step further by providing prebiotics for the SBOs so that when they arrive in your lower intestinal tract, they have the preferred foods necessary for quick colonization and growth. The 29 strains they have chosen for this product are far more comprehensive than traditional probiotics that have 5–10 strains.
Q. Is Prescript-Assist Toxic?
A. Over the last 10 years a very large number of people have taken Prescript Assist with excellent results. The overall statistics say that it works and is generally safe.
It is true that some people have felt that Prescript-Assist has not helped them and in fact they may feel worse. My assessment of this is that these people have severe gut dysbiosis and experience die-off like symptoms upon taking it. These individuals need to go more slowly and do a detoxification/cleansing program while using Prescript Assist. I recommend taking supplements such as HPDI’s Intestinal Rejuvenation Formula, digestive enzymes (Prolyt and Digase), and Dr. Richard Schultze’s Intestinal Formula #1 (if you are blocked, i.e., sluggish bowel).
Also, doing a juice flush could be important. So many people have a lifetimes’s buildup of fecal matter in their systems. Taking a single pill alone is not the solution. Doing an overall cleansing and having a good nutritional program is important for most people. Some professionals recommend that after an initial round of Prescript-Assist you only need to take a few capsules per week to maintain a healthy gut bacteria profile. You can read more about it here: http://www.prescript-assist.com/products/?gclid=CNSBvs7m3cUCFUuTfgodSp8AqQ
Q. What is the Purity of Fish Liver Oil in Your Vitamin D3 Plus Product?
A: I am always careful when formulating any product to minimize any potential toxins. Vitamin D3 and Vitamin A from fish liver oils, as are found in the HPDI Vitamin D3 Plus formula, are highly concentrated sources which means that only milligram amounts are needed. This in itself means that there would be very low levels of toxins. This is verified by testing that shows mercury levels of less than 0.003 ppm, lead levels of less than 0.005 ppm, cadmium levels of less than 0.002 ppm, and arsenic levels of less than 0.004 ppm. By ‘less than’ it means the amounts are below the detection limits. Very low, indeed!
Q. Can the Licorice in Your Intestinal Rejuvenation Formula Cause High Blood Pressure?
A. The licorice in Intestinal Rejuvenation Formula is from the powdered root of organically grown licorice. Each serving contains 40 mg. It is highly unlikely that this amount of the whole root could cause blood pressure issues.
You can reach HPDI by calling 1-800-228-4265, email support(at)IntegratedHealth.com, or visit the retail website: www.IntegratedHealth.com